TLCD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.13219262
2L-phenylalanine catabolic process (GO:0006559)7.13219262
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.76170258
4L-phenylalanine metabolic process (GO:0006558)6.76170258
5aromatic amino acid family catabolic process (GO:0009074)6.66637970
6tryptophan catabolic process (GO:0006569)6.29744762
7indole-containing compound catabolic process (GO:0042436)6.29744762
8indolalkylamine catabolic process (GO:0046218)6.29744762
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.12844115
10kynurenine metabolic process (GO:0070189)5.95725036
11tryptophan metabolic process (GO:0006568)5.92654781
12bile acid biosynthetic process (GO:0006699)5.78389302
13urea metabolic process (GO:0019627)5.75170154
14urea cycle (GO:0000050)5.75170154
15glyoxylate metabolic process (GO:0046487)5.38704084
16high-density lipoprotein particle remodeling (GO:0034375)5.31681662
17complement activation, alternative pathway (GO:0006957)5.29995296
18protein carboxylation (GO:0018214)5.28660547
19peptidyl-glutamic acid carboxylation (GO:0017187)5.28660547
20nitrogen cycle metabolic process (GO:0071941)5.25766243
21negative regulation of fibrinolysis (GO:0051918)5.24922232
22cysteine metabolic process (GO:0006534)5.18388070
23regulation of protein activation cascade (GO:2000257)5.17992281
24alpha-linolenic acid metabolic process (GO:0036109)5.17161250
25regulation of fibrinolysis (GO:0051917)5.13930730
26sulfur amino acid catabolic process (GO:0000098)5.12056775
27behavioral response to nicotine (GO:0035095)5.11990741
28L-fucose catabolic process (GO:0042355)5.04815203
29fucose catabolic process (GO:0019317)5.04815203
30L-fucose metabolic process (GO:0042354)5.04815203
31bile acid metabolic process (GO:0008206)4.92216428
32serine family amino acid catabolic process (GO:0009071)4.90299709
33regulation of complement activation (GO:0030449)4.85280888
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83820729
35aromatic amino acid family metabolic process (GO:0009072)4.79245967
36regulation of triglyceride catabolic process (GO:0010896)4.72997093
37regulation of cholesterol esterification (GO:0010872)4.70828686
38plasma lipoprotein particle remodeling (GO:0034369)4.58791872
39protein-lipid complex remodeling (GO:0034368)4.58791872
40macromolecular complex remodeling (GO:0034367)4.58791872
41reverse cholesterol transport (GO:0043691)4.57967526
42bile acid and bile salt transport (GO:0015721)4.57667483
43amine catabolic process (GO:0009310)4.53340981
44cellular biogenic amine catabolic process (GO:0042402)4.53340981
45triglyceride homeostasis (GO:0070328)4.53027808
46acylglycerol homeostasis (GO:0055090)4.53027808
47tyrosine metabolic process (GO:0006570)4.52755164
48homocysteine metabolic process (GO:0050667)4.50835082
49phospholipid efflux (GO:0033700)4.47087752
50indolalkylamine metabolic process (GO:0006586)4.45624382
51amino-acid betaine metabolic process (GO:0006577)4.41937762
52alpha-amino acid catabolic process (GO:1901606)4.36986391
53coenzyme catabolic process (GO:0009109)4.33693557
54negative regulation of cholesterol transport (GO:0032375)4.27643849
55negative regulation of sterol transport (GO:0032372)4.27643849
56cellular ketone body metabolic process (GO:0046950)4.23845419
57cellular glucuronidation (GO:0052695)4.22019906
58plasma lipoprotein particle clearance (GO:0034381)4.21959514
59lysine catabolic process (GO:0006554)4.21133326
60lysine metabolic process (GO:0006553)4.21133326
61imidazole-containing compound metabolic process (GO:0052803)4.21121307
62exogenous drug catabolic process (GO:0042738)4.15686523
63glycine metabolic process (GO:0006544)4.11750765
64benzene-containing compound metabolic process (GO:0042537)4.02908958
65arginine metabolic process (GO:0006525)4.02539097
66cholesterol efflux (GO:0033344)4.01760497
67cellular amino acid catabolic process (GO:0009063)3.98540178
68aldehyde catabolic process (GO:0046185)3.96262594
69serine family amino acid metabolic process (GO:0009069)3.95107913
70NAD biosynthetic process (GO:0009435)3.94619146
71arginine catabolic process (GO:0006527)3.94517058
72sulfation (GO:0051923)3.94287035
73low-density lipoprotein particle remodeling (GO:0034374)3.92869048
74ethanol oxidation (GO:0006069)3.90632132
75fibrinolysis (GO:0042730)3.88933843
76nicotinamide nucleotide biosynthetic process (GO:0019359)3.87561904
77pyridine nucleotide biosynthetic process (GO:0019363)3.87561904
78cofactor catabolic process (GO:0051187)3.87324818
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.83966260
80plasma lipoprotein particle assembly (GO:0034377)3.82783301
81blood coagulation, intrinsic pathway (GO:0007597)3.79535720
82drug catabolic process (GO:0042737)3.77149782
83glucuronate metabolic process (GO:0019585)3.76654053
84uronic acid metabolic process (GO:0006063)3.76654053
85serine family amino acid biosynthetic process (GO:0009070)3.75512178
86positive regulation of lipoprotein lipase activity (GO:0051006)3.73892199
87positive regulation of triglyceride lipase activity (GO:0061365)3.73892199
88very-low-density lipoprotein particle assembly (GO:0034379)3.72020153
89regulation of bile acid biosynthetic process (GO:0070857)3.70818342
90complement activation, classical pathway (GO:0006958)3.70719342
91complement activation (GO:0006956)3.68979042
92protein activation cascade (GO:0072376)3.67372763
93glutamate metabolic process (GO:0006536)3.63428420
94ketone body metabolic process (GO:1902224)3.63233631
95response to pheromone (GO:0019236)3.62333438
96cellular modified amino acid catabolic process (GO:0042219)3.61164266
97DNA deamination (GO:0045006)3.57953162
98positive regulation of lipid catabolic process (GO:0050996)3.54594064
99cholesterol homeostasis (GO:0042632)3.54364746
100cytolysis (GO:0019835)3.53448956
101urate metabolic process (GO:0046415)3.51997418
102negative regulation of lipase activity (GO:0060192)3.51846674
103organic acid catabolic process (GO:0016054)3.51649376
104carboxylic acid catabolic process (GO:0046395)3.51649376
105opsonization (GO:0008228)3.51204896
106regulation of hippo signaling (GO:0035330)3.49039963
107water-soluble vitamin biosynthetic process (GO:0042364)3.48729344
108sterol homeostasis (GO:0055092)3.48181512
109plasma lipoprotein particle organization (GO:0071827)3.47694351
110acute-phase response (GO:0006953)3.44643005
111protein-lipid complex assembly (GO:0065005)3.43292508
112dicarboxylic acid biosynthetic process (GO:0043650)3.42992236
113positive regulation of fatty acid oxidation (GO:0046321)3.40189788
114detection of light stimulus involved in sensory perception (GO:0050962)3.34501822
115detection of light stimulus involved in visual perception (GO:0050908)3.34501822
116regulation of nuclear cell cycle DNA replication (GO:0033262)3.32722546
117kidney morphogenesis (GO:0060993)3.25003615
118negative regulation of mast cell activation (GO:0033004)3.24309146
119purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.20597250
1203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.20597250
121respiratory chain complex IV assembly (GO:0008535)3.20300033
122positive regulation of guanylate cyclase activity (GO:0031284)3.15805681
123regulation of guanylate cyclase activity (GO:0031282)3.13233866
124cellular response to ATP (GO:0071318)3.03687944
125detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03324762
126negative regulation of telomere maintenance (GO:0032205)3.00856173
127regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.99086317
128regulation of sequestering of triglyceride (GO:0010889)2.98345004
129fucosylation (GO:0036065)2.96838986
130regulation of neurotransmitter uptake (GO:0051580)2.96194434
131platelet dense granule organization (GO:0060155)2.86979013
132positive regulation of sodium ion transmembrane transport (GO:1902307)2.86157524
133negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.83715763
134negative regulation of systemic arterial blood pressure (GO:0003085)2.83508283
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.80579047
136epithelial cilium movement (GO:0003351)2.74655060
137indole-containing compound metabolic process (GO:0042430)2.73921010
138sulfate transmembrane transport (GO:1902358)2.68960963
139axoneme assembly (GO:0035082)2.68609008
140negative regulation of macrophage differentiation (GO:0045650)2.63771495
141somite development (GO:0061053)2.62663916
142flavonoid metabolic process (GO:0009812)2.61123549
143nephron epithelium morphogenesis (GO:0072088)2.60992799
144nephron tubule morphogenesis (GO:0072078)2.60992799
145piRNA metabolic process (GO:0034587)2.60196746
146positive regulation of fatty acid transport (GO:2000193)2.59461275
147phosphatidylinositol acyl-chain remodeling (GO:0036149)2.59255396
148cornea development in camera-type eye (GO:0061303)2.58792262
149protein import into peroxisome matrix (GO:0016558)2.56734642
150primary amino compound metabolic process (GO:1901160)2.56471989
151regulation of action potential (GO:0098900)2.55639160
152negative regulation of reactive oxygen species metabolic process (GO:2000378)2.55021954
153cytochrome complex assembly (GO:0017004)2.54555922
154neurotransmitter metabolic process (GO:0042133)2.52332122
155neuronal action potential (GO:0019228)2.52261036
156oxidative demethylation (GO:0070989)2.52058891
157thyroid hormone metabolic process (GO:0042403)2.48367614
158negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44062302
159behavioral response to ethanol (GO:0048149)2.42413584
160photoreceptor cell maintenance (GO:0045494)2.42343126
161transepithelial transport (GO:0070633)2.39390071
162regulation of memory T cell differentiation (GO:0043380)2.38021916
163positive regulation of defense response to virus by host (GO:0002230)2.37085251
164serotonin metabolic process (GO:0042428)2.34612031
165nucleotide transmembrane transport (GO:1901679)2.32780256
166negative regulation of activin receptor signaling pathway (GO:0032926)2.32669556
167determination of left/right symmetry (GO:0007368)2.32505737
168sulfate transport (GO:0008272)2.32234319
169regulation of mesoderm development (GO:2000380)2.31490720
170cilium morphogenesis (GO:0060271)2.30031136
171cAMP catabolic process (GO:0006198)2.29064908
172negative regulation of blood pressure (GO:0045776)2.27091703
173reflex (GO:0060004)2.26960286
174positive regulation of icosanoid secretion (GO:0032305)2.26830768
175DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.26693539
176cilium movement (GO:0003341)2.26589957
177glycerophospholipid catabolic process (GO:0046475)2.25162477
178multicellular organism reproduction (GO:0032504)2.25113361
179mannosylation (GO:0097502)2.24875385
180regulation of cilium movement (GO:0003352)2.24205574
181reciprocal meiotic recombination (GO:0007131)2.23377744
182reciprocal DNA recombination (GO:0035825)2.23377744
183parturition (GO:0007567)2.22428595
184phosphatidylserine acyl-chain remodeling (GO:0036150)2.22065396
185negative regulation of multicellular organism growth (GO:0040015)2.20917516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.93096811
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.44585105
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.72238465
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.04185884
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.07997016
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.72698914
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.20149973
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14783346
9ZNF274_21170338_ChIP-Seq_K562_Hela3.99728244
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.55052920
11EZH2_22144423_ChIP-Seq_EOC_Human3.48827827
12VDR_22108803_ChIP-Seq_LS180_Human3.24555376
13GBX2_23144817_ChIP-Seq_PC3_Human2.63417760
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53655195
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42483524
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30541997
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.10604814
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06833418
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02381844
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0921882
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96365906
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90977891
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84814774
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83809782
25ER_23166858_ChIP-Seq_MCF-7_Human1.83205154
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81095335
27EWS_26573619_Chip-Seq_HEK293_Human1.80173709
28* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77968144
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.76441666
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75036898
31* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.72934639
32BCAT_22108803_ChIP-Seq_LS180_Human1.71778569
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71573456
34IGF1R_20145208_ChIP-Seq_DFB_Human1.70392187
35P300_19829295_ChIP-Seq_ESCs_Human1.68907528
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68057913
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67840203
38FUS_26573619_Chip-Seq_HEK293_Human1.67185013
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.66136589
40HTT_18923047_ChIP-ChIP_STHdh_Human1.65084367
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64362015
42STAT3_23295773_ChIP-Seq_U87_Human1.57193960
43TAF15_26573619_Chip-Seq_HEK293_Human1.55630568
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53053481
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49642609
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49253265
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47185781
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46486921
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44987081
50AR_25329375_ChIP-Seq_VCAP_Human1.43757299
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41040970
52TP53_16413492_ChIP-PET_HCT116_Human1.39462880
53TCF4_22108803_ChIP-Seq_LS180_Human1.39388079
54TCF4_23295773_ChIP-Seq_U87_Human1.39140329
55SMAD4_21799915_ChIP-Seq_A2780_Human1.38856026
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37778053
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37475237
58CBP_20019798_ChIP-Seq_JUKART_Human1.37475237
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34768416
60GATA1_22025678_ChIP-Seq_K562_Human1.33583497
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32449024
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.32449024
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31523224
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30446439
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30184653
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29729068
67TP53_22573176_ChIP-Seq_HFKS_Human1.29210008
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.28846924
69HNF4A_19822575_ChIP-Seq_HepG2_Human1.28313365
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.28136609
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.28131472
72NANOG_19829295_ChIP-Seq_ESCs_Human1.27354617
73SOX2_19829295_ChIP-Seq_ESCs_Human1.27354617
74HOXB7_26014856_ChIP-Seq_BT474_Human1.26651819
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24818610
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.22640785
77AHR_22903824_ChIP-Seq_MCF-7_Human1.22179631
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21228423
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20733803
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.18830388
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.18542390
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18314715
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17867026
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.17679561
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.17268075
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.16058815
87DROSHA_22980978_ChIP-Seq_HELA_Human1.14187435
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.13851586
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.11976047
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10885377
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10862860
92IRF1_19129219_ChIP-ChIP_H3396_Human1.10145868
93RUNX2_22187159_ChIP-Seq_PCA_Human1.09863629
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09789010
95CJUN_26792858_Chip-Seq_BT549_Human1.09368275
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09308337
97NCOR_22424771_ChIP-Seq_293T_Human1.08232898
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06590309
99REST_21632747_ChIP-Seq_MESCs_Mouse1.06072318
100* ERA_21632823_ChIP-Seq_H3396_Human1.05487327
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04395358
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02339442
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01889654
104MYC_18940864_ChIP-ChIP_HL60_Human1.01150351
105AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00809958
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00690342
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00321343
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00321343
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98366531
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.98059784
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97995426
112CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97744673
113AR_21572438_ChIP-Seq_LNCaP_Human0.97648177
114TAF2_19829295_ChIP-Seq_ESCs_Human0.97458910
115CLOCK_20551151_ChIP-Seq_293T_Human0.95887856
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.95637560
117* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94135860
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92949580
119EZH2_27294783_Chip-Seq_ESCs_Mouse0.92350690
120* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92010335
121STAT1_17558387_ChIP-Seq_HELA_Human0.88006483
122GATA4_25053715_ChIP-Seq_YYC3_Human0.84725061
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82199269
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80998960
125SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80797475
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.78084130
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74657556
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.74089332
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73516629
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72377752
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70719388
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68985179
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.68874804
134AR_20517297_ChIP-Seq_VCAP_Human0.68420055
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.66965090
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66314040
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.65748861
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.65579391
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.64901033
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64440641
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64440641
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.63931202
143CEBPB_22108803_ChIP-Seq_LS180_Human0.63881710
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63446153
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63152720
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.62483932
147SOX2_27498859_Chip-Seq_STOMACH_Mouse0.61923611
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.61648784
149CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60599516
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59927163
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59481195
152CRX_20693478_ChIP-Seq_RETINA_Mouse0.59435258
153SRF_21415370_ChIP-Seq_HL-1_Mouse0.58766742
154ERG_20517297_ChIP-Seq_VCAP_Human0.58594788
155SCL_19346495_ChIP-Seq_HPC-7_Human0.58095502
156RARB_24833708_ChIP-Seq_LIVER_Mouse0.57303996
157OCT4_21477851_ChIP-Seq_ESCs_Mouse0.54064249
158GATA2_22383799_ChIP-Seq_G1ME_Mouse0.53941326
159ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.53890729
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.53831726
161MYB_21317192_ChIP-Seq_ERMYB_Mouse0.53624560
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.53435726
163* FOXH1_21741376_ChIP-Seq_EPCs_Human0.51983441
164FLI1_27457419_Chip-Seq_LIVER_Mouse0.51645815
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51594106
166CBP_21632823_ChIP-Seq_H3396_Human0.50978561
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.50961607
168RAD21_21589869_ChIP-Seq_MESCs_Mouse0.50646370
169AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.50611747
170CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.50347387
171RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.50054389
172CDX2_22108803_ChIP-Seq_LS180_Human0.49530229
173RUNX1_27457419_Chip-Seq_LIVER_Mouse0.49270816
174FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49171904
175BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.49168941
176LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.48558710
177* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.48276624
178GATA1_19941827_ChIP-Seq_MEL_Mouse0.46895947
179GATA3_21867929_ChIP-Seq_TH1_Mouse0.46522349
180SPI1_26923725_Chip-Seq_HPCs_Mouse0.46122765
181CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.44701195
182BRD4_27068464_Chip-Seq_AML-cells_Mouse0.44694005
183CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.44482053
184STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44234814
185PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.43881804
186HNFA_21074721_ChIP-Seq_CACO-2_Human0.43398531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.94294455
2MP0005360_urolithiasis7.21928905
3MP0005085_abnormal_gallbladder_physiolo6.10320716
4MP0005365_abnormal_bile_salt6.05275634
5MP0008875_abnormal_xenobiotic_pharmacok4.83056227
6MP0003806_abnormal_nucleotide_metabolis4.06772518
7MP0004043_abnormal_pH_regulation3.95714927
8MP0003252_abnormal_bile_duct3.77608587
9MP0010329_abnormal_lipoprotein_level3.30972920
10MP0009840_abnormal_foam_cell3.08075062
11MP0005083_abnormal_biliary_tract2.63362311
12MP0003195_calcinosis2.63125462
13MP0002234_abnormal_pharynx_morphology2.58827101
14MP0008872_abnormal_physiological_respon2.52513357
15MP0005332_abnormal_amino_acid2.48892399
16MP0005645_abnormal_hypothalamus_physiol2.39130290
17MP0001666_abnormal_nutrient_absorption2.37243608
18MP0005551_abnormal_eye_electrophysiolog2.23019077
19MP0005167_abnormal_blood-brain_barrier2.14088169
20MP0000566_synostosis2.13476354
21MP0002102_abnormal_ear_morphology2.12891040
22MP0001501_abnormal_sleep_pattern2.11478272
23MP0000609_abnormal_liver_physiology2.10864189
24MP0009697_abnormal_copulation2.09067006
25MP0003191_abnormal_cellular_cholesterol2.08287007
26MP0003283_abnormal_digestive_organ2.05737821
27MP0005451_abnormal_body_composition2.04175473
28MP0004885_abnormal_endolymph2.00266271
29MP0004019_abnormal_vitamin_homeostasis1.99031032
30MP0002138_abnormal_hepatobiliary_system1.95450911
31MP0002118_abnormal_lipid_homeostasis1.91831531
32MP0000569_abnormal_digit_pigmentation1.88639013
33MP0003868_abnormal_feces_composition1.87584190
34MP0001764_abnormal_homeostasis1.78446230
35MP0008877_abnormal_DNA_methylation1.78332228
36MP0005319_abnormal_enzyme/_coenzyme1.77145782
37MP0000427_abnormal_hair_cycle1.76297293
38MP0002837_dystrophic_cardiac_calcinosis1.68896388
39MP0001986_abnormal_taste_sensitivity1.65895588
40MP0001968_abnormal_touch/_nociception1.65251473
41MP0000383_abnormal_hair_follicle1.62902771
42MP0004133_heterotaxia1.62632468
43MP0005503_abnormal_tendon_morphology1.61066939
44MP0005174_abnormal_tail_pigmentation1.57766404
45MP0003186_abnormal_redox_activity1.54678653
46MP0003656_abnormal_erythrocyte_physiolo1.52796234
47MP0008775_abnormal_heart_ventricle1.47110032
48MP0009745_abnormal_behavioral_response1.45731892
49MP0001485_abnormal_pinna_reflex1.44561640
50MP0004147_increased_porphyrin_level1.44466060
51MP0005584_abnormal_enzyme/coenzyme_acti1.43094966
52MP0003011_delayed_dark_adaptation1.42677972
53MP0005389_reproductive_system_phenotype1.41900307
54MP0009764_decreased_sensitivity_to1.41620857
55MP0001664_abnormal_digestion1.40692568
56MP0000230_abnormal_systemic_arterial1.39154768
57MP0009046_muscle_twitch1.38301464
58MP0005646_abnormal_pituitary_gland1.36421649
59MP0002736_abnormal_nociception_after1.36046948
60MP0001919_abnormal_reproductive_system1.34337039
61MP0002638_abnormal_pupillary_reflex1.34040322
62MP0005647_abnormal_sex_gland1.30221021
63MP0003045_fibrosis1.29161908
64MP0000631_abnormal_neuroendocrine_gland1.27903029
65MP0002272_abnormal_nervous_system1.27111471
66MP0000538_abnormal_urinary_bladder1.24577626
67MP0005253_abnormal_eye_physiology1.21072572
68MP0005408_hypopigmentation1.18332704
69MP0000598_abnormal_liver_morphology1.17737090
70MP0004142_abnormal_muscle_tone1.17667277
71MP0002938_white_spotting1.17527885
72MP0006072_abnormal_retinal_apoptosis1.17020257
73MP0009763_increased_sensitivity_to1.15217596
74MP0003718_maternal_effect1.13821980
75MP0003724_increased_susceptibility_to1.13668217
76MP0009643_abnormal_urine_homeostasis1.12249461
77MP0005171_absent_coat_pigmentation1.11703919
78MP0008469_abnormal_protein_level1.11171111
79MP0010368_abnormal_lymphatic_system1.10771189
80MP0002160_abnormal_reproductive_system1.10658131
81MP0000372_irregular_coat_pigmentation1.08904508
82MP0001873_stomach_inflammation1.02578143
83MP0002876_abnormal_thyroid_physiology1.02351543
84MP0005084_abnormal_gallbladder_morpholo0.99713046
85MP0002254_reproductive_system_inflammat0.98912274
86MP0001970_abnormal_pain_threshold0.98755752
87MP0009780_abnormal_chondrocyte_physiolo0.97644848
88MP0003950_abnormal_plasma_membrane0.95504301
89MP0003937_abnormal_limbs/digits/tail_de0.94990921
90MP0003436_decreased_susceptibility_to0.93617968
91MP0000470_abnormal_stomach_morphology0.93401302
92MP0005636_abnormal_mineral_homeostasis0.90351310
93MP0003136_yellow_coat_color0.89768472
94MP0002557_abnormal_social/conspecific_i0.88658349
95MP0010386_abnormal_urinary_bladder0.88179756
96MP0005464_abnormal_platelet_physiology0.87344189
97MP0010678_abnormal_skin_adnexa0.86189955
98MP0009642_abnormal_blood_homeostasis0.85740960
99MP0009785_altered_susceptibility_to0.85446290
100MP0009765_abnormal_xenobiotic_induced0.84924024
101MP0004145_abnormal_muscle_electrophysio0.84850015
102MP0002572_abnormal_emotion/affect_behav0.84126288
103MP0005386_behavior/neurological_phenoty0.83121108
104MP0004924_abnormal_behavior0.83121108
105MP0005376_homeostasis/metabolism_phenot0.82419533
106MP0001765_abnormal_ion_homeostasis0.82402782
107MP0006082_CNS_inflammation0.81280331
108MP0006276_abnormal_autonomic_nervous0.80369673
109MP0003705_abnormal_hypodermis_morpholog0.79362122
110MP0004215_abnormal_myocardial_fiber0.78914449
111MP0001486_abnormal_startle_reflex0.78601161
112MP0006036_abnormal_mitochondrial_physio0.78017360
113MP0005195_abnormal_posterior_eye0.77315904
114MP0002735_abnormal_chemical_nociception0.77197645
115MP0004782_abnormal_surfactant_physiolog0.76453791
116MP0001502_abnormal_circadian_rhythm0.76036039
117MP0004084_abnormal_cardiac_muscle0.75983858
118MP0003119_abnormal_digestive_system0.75779116
119MP0002653_abnormal_ependyma_morphology0.75664673
120MP0005395_other_phenotype0.75326833
121MP0005220_abnormal_exocrine_pancreas0.75255287
122MP0002064_seizures0.74204761
123MP0000604_amyloidosis0.73731087
124MP0004484_altered_response_of0.73459941
125MP0002733_abnormal_thermal_nociception0.72568365
126MP0001835_abnormal_antigen_presentation0.69944509
127MP0000516_abnormal_urinary_system0.68123693
128MP0002971_abnormal_brown_adipose0.65508268
129MP0005266_abnormal_metabolism0.65003159
130MP0005334_abnormal_fat_pad0.64891809
131MP0002078_abnormal_glucose_homeostasis0.64819598
132MP0000639_abnormal_adrenal_gland0.64513991
133MP0005670_abnormal_white_adipose0.63878732
134MP0001853_heart_inflammation0.62766770
135MP0002419_abnormal_innate_immunity0.58801977
136MP0001845_abnormal_inflammatory_respons0.58365259
137MP0005025_abnormal_response_to0.56969109
138MP0005535_abnormal_body_temperature0.53397076
139MP0000579_abnormal_nail_morphology0.51641196
140MP0002132_abnormal_respiratory_system0.50886051
141MP0001119_abnormal_female_reproductive0.49715443
142MP0004381_abnormal_hair_follicle0.47497909
143MP0005448_abnormal_energy_balance0.47486535
144MP0002136_abnormal_kidney_physiology0.47240727
145MP0001756_abnormal_urination0.47124454
146MP0009115_abnormal_fat_cell0.46576711
147MP0009053_abnormal_anal_canal0.46553645
148MP0003699_abnormal_female_reproductive0.46455810
149MP0008873_increased_physiological_sensi0.46150862
150MP0002928_abnormal_bile_duct0.45389231
151MP0006035_abnormal_mitochondrial_morpho0.45099415
152MP0002060_abnormal_skin_morphology0.43710995
153MP0000685_abnormal_immune_system0.41760259
154MP0005166_decreased_susceptibility_to0.41088016
155MP0004130_abnormal_muscle_cell0.40916207
156MP0003646_muscle_fatigue0.40178621
157MP0005248_abnormal_Harderian_gland0.39180732
158MP0005164_abnormal_response_to0.39085480
159MP0001881_abnormal_mammary_gland0.38582545
160MP0001661_extended_life_span0.36714875
161MP0001243_abnormal_dermal_layer0.36314864
162MP0001800_abnormal_humoral_immune0.35294324
163MP0003075_altered_response_to0.35218889
164MP0004883_abnormal_blood_vessel0.34872898
165MP0000249_abnormal_blood_vessel0.34476057
166MP0001533_abnormal_skeleton_physiology0.33314115
167MP0003953_abnormal_hormone_level0.32773625
168MP0005075_abnormal_melanosome_morpholog0.31776382
169MP0003638_abnormal_response/metabolism_0.31488846
170MP0009384_cardiac_valve_regurgitation0.31208635
171MP0002168_other_aberrant_phenotype0.30996449
172MP0003690_abnormal_glial_cell0.30785638

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.13283664
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.03513870
3Deep venous thrombosis (HP:0002625)6.93455187
4Prolonged partial thromboplastin time (HP:0003645)6.53327890
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.28106153
6Hypobetalipoproteinemia (HP:0003563)6.12820147
7Xanthomatosis (HP:0000991)5.87160387
8Complement deficiency (HP:0004431)5.20703988
9Pancreatic cysts (HP:0001737)5.18914477
10Hyperlipoproteinemia (HP:0010980)5.13046985
11Joint hemorrhage (HP:0005261)4.95489720
12Hypolipoproteinemia (HP:0010981)4.57170524
13Abnormality of the common coagulation pathway (HP:0010990)4.33947770
14Epidermoid cyst (HP:0200040)4.33428251
15Hyperammonemia (HP:0001987)4.33365256
16Pancreatic fibrosis (HP:0100732)4.27012386
17Hyperglycinemia (HP:0002154)4.23404554
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17033099
19Abnormality of methionine metabolism (HP:0010901)4.14068179
20Fat malabsorption (HP:0002630)4.13327434
21Abnormality of the renal cortex (HP:0011035)4.10018592
22Congenital stationary night blindness (HP:0007642)4.02826199
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.01990161
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00419809
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99231562
26Abnormality of midbrain morphology (HP:0002418)3.98430120
27Molar tooth sign on MRI (HP:0002419)3.98430120
28Hypoalphalipoproteinemia (HP:0003233)3.96783088
29True hermaphroditism (HP:0010459)3.91105308
30Abnormality of complement system (HP:0005339)3.90222003
31Abnormality of the intrinsic pathway (HP:0010989)3.88512185
32Abnormality of pyrimidine metabolism (HP:0004353)3.84677720
33Ketosis (HP:0001946)3.78229104
34Hyperglycinuria (HP:0003108)3.71242706
35Tubular atrophy (HP:0000092)3.69788077
36Conjugated hyperbilirubinemia (HP:0002908)3.64117338
37Hypoglycemic coma (HP:0001325)3.63560050
38Abnormality of serine family amino acid metabolism (HP:0010894)3.63040223
39Abnormality of glycine metabolism (HP:0010895)3.63040223
40Nephronophthisis (HP:0000090)3.55948238
41Spontaneous abortion (HP:0005268)3.46720053
42Abnormality of fatty-acid metabolism (HP:0004359)3.42964349
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42162595
44Hypercholesterolemia (HP:0003124)3.39141812
45Type II lissencephaly (HP:0007260)3.30426738
46Decreased circulating renin level (HP:0003351)3.29351778
47Abnormality of the renal medulla (HP:0100957)3.29057760
48Hyperbilirubinemia (HP:0002904)3.28439007
49Myocardial infarction (HP:0001658)3.23066908
50Steatorrhea (HP:0002570)3.21706924
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17274180
52Abnormality of alanine metabolism (HP:0010916)3.17274180
53Hyperalaninemia (HP:0003348)3.17274180
54Abnormality of serum amino acid levels (HP:0003112)3.15282010
55Increased corneal curvature (HP:0100692)3.15159578
56Keratoconus (HP:0000563)3.15159578
57Cystic liver disease (HP:0006706)3.13994202
58Recurrent gram-negative bacterial infections (HP:0005420)3.11727993
59Systemic lupus erythematosus (HP:0002725)3.08746355
60Polydipsia (HP:0001959)3.06817249
61Abnormal drinking behavior (HP:0030082)3.06817249
62Abnormality of nucleobase metabolism (HP:0010932)3.06527747
63Pendular nystagmus (HP:0012043)2.95609386
64Hyperventilation (HP:0002883)2.95144075
65Attenuation of retinal blood vessels (HP:0007843)2.90975013
66Hepatocellular carcinoma (HP:0001402)2.88910419
67Abolished electroretinogram (ERG) (HP:0000550)2.83432876
68Concave nail (HP:0001598)2.80477868
69Delayed CNS myelination (HP:0002188)2.78176733
70Chronic hepatic failure (HP:0100626)2.72018808
71Hypochromic microcytic anemia (HP:0004840)2.70070048
72Metabolic acidosis (HP:0001942)2.68875322
73Acanthocytosis (HP:0001927)2.67682575
74Abnormality of purine metabolism (HP:0004352)2.67452761
75Congenital sensorineural hearing impairment (HP:0008527)2.66533666
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62664457
77Dicarboxylic aciduria (HP:0003215)2.62664457
78Gingival bleeding (HP:0000225)2.56280343
79Gaze-evoked nystagmus (HP:0000640)2.55923518
80Lethargy (HP:0001254)2.54354808
81Genetic anticipation (HP:0003743)2.53175133
82Glomerulonephritis (HP:0000099)2.50644326
83Chorioretinal atrophy (HP:0000533)2.49533536
84Medial flaring of the eyebrow (HP:0010747)2.49460152
85Furrowed tongue (HP:0000221)2.48820297
86Generalized aminoaciduria (HP:0002909)2.48788451
87Ketoacidosis (HP:0001993)2.47256160
88Cerebellar dysplasia (HP:0007033)2.46649930
89Vascular calcification (HP:0004934)2.44320724
90Skin nodule (HP:0200036)2.42649695
91Renal cortical cysts (HP:0000803)2.37159651
92Sclerocornea (HP:0000647)2.36839286
93Sensorimotor neuropathy (HP:0007141)2.36582396
94Congenital hepatic fibrosis (HP:0002612)2.36051438
95Large for gestational age (HP:0001520)2.32204235
96Thrombophlebitis (HP:0004418)2.31752814
97Pancreatitis (HP:0001733)2.31569754
98Polyuria (HP:0000103)2.31342496
99Inability to walk (HP:0002540)2.29155896
100Decreased central vision (HP:0007663)2.23946659
101Abnormal biliary tract physiology (HP:0012439)2.23025468
102Bile duct proliferation (HP:0001408)2.23025468
103Abnormal gallbladder morphology (HP:0012437)2.22779795
104Congenital, generalized hypertrichosis (HP:0004540)2.22679666
105Menorrhagia (HP:0000132)2.22114574
106Aplasia/Hypoplasia of the tibia (HP:0005772)2.21525860
107Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20899473
108Malnutrition (HP:0004395)2.20869991
109Cerebral edema (HP:0002181)2.20465766
110Hypoplasia of the pons (HP:0012110)2.20448141
111Abnormality of the pons (HP:0007361)2.20428510
112Cardiovascular calcification (HP:0011915)2.17715153
113Hypoglycemic seizures (HP:0002173)2.17317629
114Abnormal rod and cone electroretinograms (HP:0008323)2.16938180
115Mitral stenosis (HP:0001718)2.16231246
116Progressive cerebellar ataxia (HP:0002073)2.15632905
117Abnormal gallbladder physiology (HP:0012438)2.14819325
118Cholecystitis (HP:0001082)2.14819325
119Cholelithiasis (HP:0001081)2.13796751
120Spastic diplegia (HP:0001264)2.13443840
121Hypothermia (HP:0002045)2.11914136
122Brushfield spots (HP:0001088)2.10803246
123Amyloidosis (HP:0011034)2.09786426
124Irritability (HP:0000737)2.09478932
125Dynein arm defect of respiratory motile cilia (HP:0012255)2.08776745
126Absent/shortened dynein arms (HP:0200106)2.08776745
127Esophageal varix (HP:0002040)2.08214036
128Severe muscular hypotonia (HP:0006829)2.08018786
129Gout (HP:0001997)2.07730390
130Abnormality of renin-angiotensin system (HP:0000847)2.07639191
131Poikilocytosis (HP:0004447)2.06615813
132Aplasia/Hypoplasia of the tongue (HP:0010295)2.06057222
133Tubulointerstitial fibrosis (HP:0005576)2.05836011
134Enlarged kidneys (HP:0000105)2.05342858
135Neonatal onset (HP:0003623)2.04080647
136Protruding tongue (HP:0010808)2.03497046
137Aplasia/Hypoplasia of the patella (HP:0006498)2.03132306
138Patellar aplasia (HP:0006443)2.02138534
139Confusion (HP:0001289)2.01544098
140Autoimmune thrombocytopenia (HP:0001973)2.01228938
141Nausea (HP:0002018)1.99772042
142Lissencephaly (HP:0001339)1.98733356
143Stomach cancer (HP:0012126)1.97629355
144Progressive inability to walk (HP:0002505)1.97089459
145Abnormal respiratory motile cilium morphology (HP:0005938)1.96507890
146Abnormal respiratory epithelium morphology (HP:0012253)1.96507890
147Tachypnea (HP:0002789)1.95717836
148Lip pit (HP:0100267)1.95548340
149Hemorrhage of the eye (HP:0011885)1.95101768
150Abnormal urine output (HP:0012590)1.94853156
151Elevated hepatic transaminases (HP:0002910)1.94805737
152Vomiting (HP:0002013)1.94495224
153Abnormality of iron homeostasis (HP:0011031)1.94128321
154Opisthotonus (HP:0002179)1.93285341
155Male pseudohermaphroditism (HP:0000037)1.93231160
156Anencephaly (HP:0002323)1.92603173
157Proximal tubulopathy (HP:0000114)1.90400733
158Hypoalbuminemia (HP:0003073)1.89895964
159Abnormal albumin level (HP:0012116)1.89895964
160Pachygyria (HP:0001302)1.89841961
161Ectopic kidney (HP:0000086)1.89676369
162Alkalosis (HP:0001948)1.87611289
163Postaxial foot polydactyly (HP:0001830)1.87146067
164Abnormality of transition element cation homeostasis (HP:0011030)1.86519928
165Abnormal cartilage morphology (HP:0002763)1.85581261
166Hydroxyprolinuria (HP:0003080)1.84546970
167Abnormality of proline metabolism (HP:0010907)1.84546970
168Abnormality of renal excretion (HP:0011036)1.84530489
169Pulmonary embolism (HP:0002204)1.82838695
170Aplasia/Hypoplasia of the spleen (HP:0010451)1.82399994
171Metabolic alkalosis (HP:0200114)1.82270417
172Depressed nasal tip (HP:0000437)1.81443049
173Abnormality of the gallbladder (HP:0005264)1.81357574
174Rickets (HP:0002748)1.81002895
175Hyperglycemia (HP:0003074)1.79713348
176Clumsiness (HP:0002312)1.79426803
177Nephritis (HP:0000123)1.79189086
178Methylmalonic aciduria (HP:0012120)1.78953232
179Late onset (HP:0003584)1.78540290
180Hypertriglyceridemia (HP:0002155)1.78479288
181Methylmalonic acidemia (HP:0002912)1.76486729
182Hypophosphatemic rickets (HP:0004912)1.75018376
183Absent thumb (HP:0009777)1.74712453
184Gait imbalance (HP:0002141)1.74438511
185Pigmentary retinal degeneration (HP:0001146)1.74062892
186Fair hair (HP:0002286)1.73992951
187Bony spicule pigmentary retinopathy (HP:0007737)1.73640223
188Glycosuria (HP:0003076)1.73574536
189Congenital primary aphakia (HP:0007707)1.73251870
190Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72316003
191Broad-based gait (HP:0002136)1.71274007
192Bulbous nose (HP:0000414)1.70809315
193Conical tooth (HP:0000698)1.70083850
194Hypoplasia of the uterus (HP:0000013)1.66290917
195Aplasia/hypoplasia of the uterus (HP:0008684)1.65814937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.21250845
2WNK44.20875731
3LATS13.99245799
4ERBB43.70047881
5TAOK33.67118462
6FGFR43.34993093
7STK38L3.27864642
8STK393.22092798
9ERN13.19228120
10ZAK2.89354904
11SIK12.69292750
12TLK12.19682093
13ABL22.08894994
14MAP4K22.06490238
15MAP3K62.00594863
16MAPKAPK31.96748308
17IRAK31.91510335
18LATS21.89462709
19INSRR1.89321912
20TYK21.88477889
21WNK31.87363124
22MAP3K141.83490659
23FLT31.79259369
24NEK91.73180248
25MAPK111.69053436
26PIK3CG1.62284539
27DAPK21.61061729
28EPHA31.53761347
29ACVR1B1.51696965
30TBK11.51391234
31ADRBK11.47687272
32MAP2K41.45187683
33OXSR11.44150609
34MAPK131.41762708
35STK31.34949335
36FRK1.29827723
37IKBKE1.29487621
38TIE11.28983793
39MUSK1.25063053
40PINK11.24191615
41PRKAA21.16734356
42JAK21.16286384
43JAK31.13930768
44MST1R1.13855523
45CAMKK21.13687052
46JAK11.10283687
47CCNB11.09306883
48PIK3CA1.07924644
49CASK1.07663277
50TNIK1.07585905
51MAP2K31.07017858
52NUAK11.06486294
53PNCK1.04198650
54MAP3K31.04088472
55KIT0.98541789
56PRKCE0.97758519
57MAP3K130.97479540
58WNK10.97130535
59MAPKAPK50.95285622
60TXK0.94773470
61TEC0.94405275
62PKN20.92760573
63PAK30.92324730
64PLK40.92222843
65CAMK10.91558971
66PTK2B0.90838067
67TRPM70.90550313
68IKBKB0.90204230
69MAPK150.88035014
70CDK80.85326921
71MAP4K10.85106486
72FER0.83994729
73CHUK0.79941721
74CSF1R0.77936932
75PBK0.77589902
76PRKCG0.77284572
77AKT30.76564170
78MAPK40.75941741
79KDR0.72485692
80MAP3K50.70483114
81MAP3K40.70365854
82MAP2K60.69831871
83RPS6KA60.69507929
84RAF10.68127481
85BRAF0.66777444
86PRKCI0.66529984
87EIF2AK20.64383527
88BLK0.63578909
89MKNK20.63411358
90STK160.62816825
91BRSK20.62459000
92IRAK40.62318802
93NLK0.61900404
94BMPR1B0.60859705
95TGFBR20.59943025
96PRKAA10.59622038
97MAP3K20.58582052
98TGFBR10.58468149
99EPHB20.57497241
100CDK60.57465268
101TAOK20.57147897
102BMPR20.55693029
103MAP3K110.55626966
104CAMK1G0.55204711
105BTK0.54711513
106PIM10.54690888
107EIF2AK10.54213554
108ABL10.53139884
109CAMK1D0.52188845
110PHKG10.51878539
111PHKG20.51878539
112ERBB20.51854386
113LYN0.50796494
114CSNK1A1L0.50587191
115CAMK40.49780854
116CSNK1G20.49546794
117MAP2K10.49526649
118CHEK20.48235098
119CSNK1G30.45200798
120TRIM280.45006586
121CSK0.44585820
122RPS6KA50.44118747
123CDK40.43809101
124DYRK20.42703924
125SGK20.41765887
126MAPK120.41506673
127CAMK2A0.40869331
128PRKCZ0.40613868
129CSNK1A10.40186897
130PRKACA0.39855047
131MAP3K70.39676108
132NTRK30.39550315
133MET0.38490786
134MST40.38243503
135STK240.38085191
136IGF1R0.37965859
137GRK10.37858226
138NEK20.37434445
139PRKCA0.37336280
140KSR20.36197504
141PKN10.35314119
142ADRBK20.35190986
143PTK60.34873742
144SGK30.34463221
145GRK50.34173928
146FGFR30.33985899
147PRKACG0.33452322
148NME20.32881557
149MAP2K70.32417664
150MYLK0.32155397
151PRKCQ0.31082696
152CSNK1G10.31070642
153VRK10.30120430
154MAPK70.29929312
155ILK0.29717243
156ZAP700.29307449
157TAOK10.28790767
158MAPK30.28706250
159FGFR20.28572254
160IRAK10.28011548
161PRKCH0.27917221
162PLK20.27888779
163MARK10.27620494
164MAP3K10.26544610
165ERBB30.26463220

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.58337571
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43366817
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00589115
4Arginine biosynthesis_Homo sapiens_hsa002202.90068205
5Nitrogen metabolism_Homo sapiens_hsa009102.81988989
6Complement and coagulation cascades_Homo sapiens_hsa046102.80955669
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68421736
8Tryptophan metabolism_Homo sapiens_hsa003802.64664517
9Phototransduction_Homo sapiens_hsa047442.52248085
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.49664394
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45657123
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41393936
13Fatty acid degradation_Homo sapiens_hsa000712.38693897
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32122154
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31985008
16Peroxisome_Homo sapiens_hsa041462.19302352
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17549729
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17246356
19Chemical carcinogenesis_Homo sapiens_hsa052042.02272890
20Staphylococcus aureus infection_Homo sapiens_hsa051501.99995156
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.99912463
22Histidine metabolism_Homo sapiens_hsa003401.98212568
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96154422
24Caffeine metabolism_Homo sapiens_hsa002321.94554637
25Butanoate metabolism_Homo sapiens_hsa006501.92240989
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.90824291
27Propanoate metabolism_Homo sapiens_hsa006401.88358562
28Retinol metabolism_Homo sapiens_hsa008301.85788289
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.82853988
30beta-Alanine metabolism_Homo sapiens_hsa004101.81243947
31PPAR signaling pathway_Homo sapiens_hsa033201.81220608
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73988188
33Fatty acid metabolism_Homo sapiens_hsa012121.71126367
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67964512
35Ether lipid metabolism_Homo sapiens_hsa005651.62048433
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61480964
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59768094
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59513975
39Selenocompound metabolism_Homo sapiens_hsa004501.57639013
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53328710
41Phenylalanine metabolism_Homo sapiens_hsa003601.50091716
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46484144
43Folate biosynthesis_Homo sapiens_hsa007901.42590276
44Tyrosine metabolism_Homo sapiens_hsa003501.38500187
45Fatty acid elongation_Homo sapiens_hsa000621.32010818
46Sulfur metabolism_Homo sapiens_hsa009201.31657831
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.28826359
48Vitamin B6 metabolism_Homo sapiens_hsa007501.28457150
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28448134
50Starch and sucrose metabolism_Homo sapiens_hsa005001.28087309
51Steroid biosynthesis_Homo sapiens_hsa001001.27692648
52Bile secretion_Homo sapiens_hsa049761.25423856
53Nicotine addiction_Homo sapiens_hsa050331.25101543
54Pyruvate metabolism_Homo sapiens_hsa006201.21952673
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19859891
56Mineral absorption_Homo sapiens_hsa049781.18198287
57Taste transduction_Homo sapiens_hsa047421.17661695
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14501142
59Biosynthesis of amino acids_Homo sapiens_hsa012301.14058741
60ABC transporters_Homo sapiens_hsa020101.12736100
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11051276
62Homologous recombination_Homo sapiens_hsa034401.06585691
63Fat digestion and absorption_Homo sapiens_hsa049751.05551874
64Sulfur relay system_Homo sapiens_hsa041221.03442244
65Vitamin digestion and absorption_Homo sapiens_hsa049771.01673167
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01564067
67Carbon metabolism_Homo sapiens_hsa012001.00860357
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.98109419
69Arginine and proline metabolism_Homo sapiens_hsa003300.96081201
70RNA polymerase_Homo sapiens_hsa030200.89784754
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.88019113
72Fanconi anemia pathway_Homo sapiens_hsa034600.87986287
73Salivary secretion_Homo sapiens_hsa049700.87918210
74Morphine addiction_Homo sapiens_hsa050320.86885715
75Basal transcription factors_Homo sapiens_hsa030220.83834627
76Olfactory transduction_Homo sapiens_hsa047400.83794252
77One carbon pool by folate_Homo sapiens_hsa006700.83743907
78Insulin secretion_Homo sapiens_hsa049110.83239547
79Oxidative phosphorylation_Homo sapiens_hsa001900.82645013
80Circadian entrainment_Homo sapiens_hsa047130.81595276
81Pentose phosphate pathway_Homo sapiens_hsa000300.79609387
82Protein export_Homo sapiens_hsa030600.78940817
83Lysine degradation_Homo sapiens_hsa003100.77557922
84Serotonergic synapse_Homo sapiens_hsa047260.73781428
85Glutathione metabolism_Homo sapiens_hsa004800.70552573
86Calcium signaling pathway_Homo sapiens_hsa040200.68550378
87Dorso-ventral axis formation_Homo sapiens_hsa043200.66186172
88Glutamatergic synapse_Homo sapiens_hsa047240.60034699
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.57235141
90Glycerolipid metabolism_Homo sapiens_hsa005610.55932304
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55109633
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54543603
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50635655
94Metabolic pathways_Homo sapiens_hsa011000.49005193
95Renin secretion_Homo sapiens_hsa049240.48333049
96Protein digestion and absorption_Homo sapiens_hsa049740.48177189
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42227846
98Dopaminergic synapse_Homo sapiens_hsa047280.42139425
99Fatty acid biosynthesis_Homo sapiens_hsa000610.42000101
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39486585
101Long-term depression_Homo sapiens_hsa047300.39359511
102GABAergic synapse_Homo sapiens_hsa047270.38959295
103Parkinsons disease_Homo sapiens_hsa050120.37772093
104Linoleic acid metabolism_Homo sapiens_hsa005910.36989702
105RNA degradation_Homo sapiens_hsa030180.35969085
106Renin-angiotensin system_Homo sapiens_hsa046140.35766488
107Circadian rhythm_Homo sapiens_hsa047100.34343483
108Alzheimers disease_Homo sapiens_hsa050100.33841442
109cAMP signaling pathway_Homo sapiens_hsa040240.31999948
110Cardiac muscle contraction_Homo sapiens_hsa042600.31862677
111Collecting duct acid secretion_Homo sapiens_hsa049660.31569682
112Sphingolipid metabolism_Homo sapiens_hsa006000.31527129
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30544558
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30064650
115Prion diseases_Homo sapiens_hsa050200.28237601
116Galactose metabolism_Homo sapiens_hsa000520.27548620
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22230652
118Fructose and mannose metabolism_Homo sapiens_hsa000510.16397706
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.14318677
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13560764
121Insulin resistance_Homo sapiens_hsa049310.13521776
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.13296989
123Ovarian steroidogenesis_Homo sapiens_hsa049130.11268527
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10630786
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09365085
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.06047275
127Arachidonic acid metabolism_Homo sapiens_hsa005900.05839419
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.05760127
129AMPK signaling pathway_Homo sapiens_hsa04152-0.1294756
130Allograft rejection_Homo sapiens_hsa05330-0.1231473
131Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1138835
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1027664
133Glucagon signaling pathway_Homo sapiens_hsa04922-0.0955376
134Other glycan degradation_Homo sapiens_hsa00511-0.0901822
135Hepatitis C_Homo sapiens_hsa05160-0.0861684
136Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0703666
137Pertussis_Homo sapiens_hsa05133-0.0580762
138Graft-versus-host disease_Homo sapiens_hsa05332-0.0542272
139NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0399957
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321-0.0389999
141African trypanosomiasis_Homo sapiens_hsa05143-0.0338686
142Regulation of autophagy_Homo sapiens_hsa04140-0.0286061
143Pyrimidine metabolism_Homo sapiens_hsa00240-0.0123212
144Legionellosis_Homo sapiens_hsa05134-0.0097772
145Malaria_Homo sapiens_hsa05144-0.0025914

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