TLDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.80077591
2lysine metabolic process (GO:0006553)5.43086216
3lysine catabolic process (GO:0006554)5.43086216
4cellular ketone body metabolic process (GO:0046950)5.24413871
5ketone body metabolic process (GO:1902224)4.48823366
6L-phenylalanine catabolic process (GO:0006559)4.39357239
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.39357239
8L-phenylalanine metabolic process (GO:0006558)4.38921989
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.38921989
10oxaloacetate metabolic process (GO:0006107)4.29798932
11negative regulation of axon guidance (GO:1902668)4.26434615
12COPI coating of Golgi vesicle (GO:0048205)4.25813018
13Golgi transport vesicle coating (GO:0048200)4.25813018
14alpha-linolenic acid metabolic process (GO:0036109)4.24611670
15positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.23675089
162-oxoglutarate metabolic process (GO:0006103)4.23310912
17negative regulation of axon extension involved in axon guidance (GO:0048843)4.17893482
18desmosome organization (GO:0002934)4.04183689
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.98138073
20aspartate family amino acid catabolic process (GO:0009068)3.95833474
21cysteine metabolic process (GO:0006534)3.91270960
22glyoxylate metabolic process (GO:0046487)3.77954873
23purine nucleotide salvage (GO:0032261)3.72366808
24regulation of fatty acid beta-oxidation (GO:0031998)3.70719544
25kynurenine metabolic process (GO:0070189)3.69900711
26aromatic amino acid family catabolic process (GO:0009074)3.67479503
27regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.64234756
28nucleotide salvage (GO:0043173)3.59744957
29sulfur amino acid catabolic process (GO:0000098)3.58739336
30cellular response to fluid shear stress (GO:0071498)3.56932465
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.52645953
32negative regulation of keratinocyte proliferation (GO:0010839)3.51549062
33ethanol oxidation (GO:0006069)3.48420818
34bile acid biosynthetic process (GO:0006699)3.48223462
35acetyl-CoA metabolic process (GO:0006084)3.47429908
36urea cycle (GO:0000050)3.46196887
37urea metabolic process (GO:0019627)3.46196887
38IMP biosynthetic process (GO:0006188)3.45430310
39ribonucleoprotein complex disassembly (GO:0032988)3.41792250
40dosage compensation (GO:0007549)3.41682300
41positive regulation of fatty acid beta-oxidation (GO:0032000)3.33116138
42homeostasis of number of cells within a tissue (GO:0048873)3.31588335
43negative regulation of fibrinolysis (GO:0051918)3.30737831
44organelle disassembly (GO:1903008)3.26961841
45establishment of planar polarity (GO:0001736)3.25594895
46establishment of tissue polarity (GO:0007164)3.25594895
47valine metabolic process (GO:0006573)3.24887972
48regulation of centriole replication (GO:0046599)3.22766063
49AMP metabolic process (GO:0046033)3.20196418
50fatty acid beta-oxidation (GO:0006635)3.18488779
51negative regulation of cholesterol transport (GO:0032375)3.17825127
52negative regulation of sterol transport (GO:0032372)3.17825127
534-hydroxyproline metabolic process (GO:0019471)3.15543937
54peptidyl-glutamic acid carboxylation (GO:0017187)3.14746281
55protein carboxylation (GO:0018214)3.14746281
56polarized epithelial cell differentiation (GO:0030859)3.13845593
57alpha-amino acid catabolic process (GO:1901606)3.13738335
58regulation of hippo signaling (GO:0035330)3.13233070
59keratinocyte development (GO:0003334)3.11838322
60snRNA transcription (GO:0009301)3.11593359
61positive regulation of glycolytic process (GO:0045821)3.10875880
62amino-acid betaine metabolic process (GO:0006577)3.10576404
63nitrogen cycle metabolic process (GO:0071941)3.05363116
64neuron projection extension involved in neuron projection guidance (GO:1902284)3.04517062
65axon extension involved in axon guidance (GO:0048846)3.04517062
66tricarboxylic acid metabolic process (GO:0072350)3.04046521
67fatty acid oxidation (GO:0019395)3.01813486
68imidazole-containing compound metabolic process (GO:0052803)3.00892693
69fatty acid catabolic process (GO:0009062)3.00456654
70IMP metabolic process (GO:0046040)2.99233716
71glycine metabolic process (GO:0006544)2.98625649
72protein-DNA complex disassembly (GO:0032986)2.98405059
73nucleosome disassembly (GO:0006337)2.98405059
74regulation of keratinocyte proliferation (GO:0010837)2.96719163
75progesterone metabolic process (GO:0042448)2.95535317
76high-density lipoprotein particle remodeling (GO:0034375)2.95470794
77indolalkylamine catabolic process (GO:0046218)2.95396771
78tryptophan catabolic process (GO:0006569)2.95396771
79indole-containing compound catabolic process (GO:0042436)2.95396771
80cellular modified amino acid catabolic process (GO:0042219)2.94627898
81negative regulation of erythrocyte differentiation (GO:0045647)2.93607287
82regulation of protein activation cascade (GO:2000257)2.92772295
83synaptonemal complex assembly (GO:0007130)2.91949835
84regulation of cholesterol homeostasis (GO:2000188)2.91665571
85lipid oxidation (GO:0034440)2.91399603
86tricarboxylic acid cycle (GO:0006099)2.89420411
87cellular amino acid catabolic process (GO:0009063)2.87805056
88negative regulation of chondrocyte differentiation (GO:0032331)2.87804059
89viral mRNA export from host cell nucleus (GO:0046784)2.87042729
90aspartate family amino acid metabolic process (GO:0009066)2.85475821
91regulation of fibrinolysis (GO:0051917)2.85304172
92regulation of axon guidance (GO:1902667)2.83814652
93dicarboxylic acid biosynthetic process (GO:0043650)2.82389596
94keratinocyte proliferation (GO:0043616)2.79860211
95cornea development in camera-type eye (GO:0061303)2.78800350
96folic acid-containing compound biosynthetic process (GO:0009396)2.78093094
97regulation of fatty acid oxidation (GO:0046320)2.77588057
98tryptophan metabolic process (GO:0006568)2.76946112
99regulation of glycolytic process (GO:0006110)2.76660521
100regulation of cholesterol metabolic process (GO:0090181)2.76457857
101behavioral response to nicotine (GO:0035095)2.76438024
102monocarboxylic acid catabolic process (GO:0072329)2.76320020
103serine family amino acid biosynthetic process (GO:0009070)2.74078509
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71302609
105antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71302609
106limb bud formation (GO:0060174)2.71152818
107regulation of complement activation (GO:0030449)2.69826441
108bile acid metabolic process (GO:0008206)2.69620248
109serine family amino acid metabolic process (GO:0009069)2.69227702
110glutamate metabolic process (GO:0006536)2.68942989
111embryonic retina morphogenesis in camera-type eye (GO:0060059)2.67817193
112arginine metabolic process (GO:0006525)2.66580483
113plasma lipoprotein particle clearance (GO:0034381)2.66242168
114regulation of chromatin binding (GO:0035561)2.65769070
115metanephric nephron tubule development (GO:0072234)2.65562444
116metanephric tubule development (GO:0072170)2.65562444
117branched-chain amino acid metabolic process (GO:0009081)2.65293679
118retinal ganglion cell axon guidance (GO:0031290)2.65236027
119labyrinthine layer blood vessel development (GO:0060716)2.65220437
120lateral sprouting from an epithelium (GO:0060601)2.64881220
121cell adhesion mediated by integrin (GO:0033627)2.64377090
122negative chemotaxis (GO:0050919)2.61812191
123type B pancreatic cell proliferation (GO:0044342)2.60662589
124regulation of axon extension involved in axon guidance (GO:0048841)2.59673978
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55874838
126ganglion development (GO:0061548)2.54987548
127axonal fasciculation (GO:0007413)2.54244330
128neural crest cell development (GO:0014032)2.52150065
129peptidyl-histidine modification (GO:0018202)2.51559928
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49952956
131cell migration involved in sprouting angiogenesis (GO:0002042)2.46555618
132facial nerve structural organization (GO:0021612)2.45359662
133regulation of mesoderm development (GO:2000380)2.43907873
134cilium morphogenesis (GO:0060271)2.43337136
135calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.40385152
136ectoderm development (GO:0007398)2.38760581
137positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.37759908
138negative regulation of telomere maintenance (GO:0032205)2.36809739
139positive regulation of mitochondrial fission (GO:0090141)2.34236362
140regulation of transforming growth factor beta2 production (GO:0032909)2.34041733
141mesodermal cell differentiation (GO:0048333)2.32156836
142nonmotile primary cilium assembly (GO:0035058)2.31463360
143negative regulation of stem cell proliferation (GO:2000647)2.30526635
144cardiac right ventricle morphogenesis (GO:0003215)2.30244931
145kidney morphogenesis (GO:0060993)2.29537243
146sequestering of extracellular ligand from receptor (GO:0035581)2.28093837
147chondrocyte proliferation (GO:0035988)2.23815213
148negative regulation of osteoblast proliferation (GO:0033689)2.22227787
149paraxial mesoderm development (GO:0048339)2.19749267
150head development (GO:0060322)2.19710137
151lung vasculature development (GO:0060426)2.19271548
152smooth muscle tissue development (GO:0048745)2.17825915
153lymphangiogenesis (GO:0001946)2.17591478
154regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.17556412
155protein-cofactor linkage (GO:0018065)2.17241838
156notochord development (GO:0030903)2.15437490
157cell-substrate junction assembly (GO:0007044)2.15073691
158substrate-dependent cell migration (GO:0006929)2.13081804
159platelet dense granule organization (GO:0060155)2.12180095
160heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.11727777
161establishment or maintenance of monopolar cell polarity (GO:0061339)2.09995718
162establishment of monopolar cell polarity (GO:0061162)2.09995718
163homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.09047649
164neuron recognition (GO:0008038)2.08889885
165cellular response to vitamin D (GO:0071305)2.08440641
166negative regulation of cartilage development (GO:0061037)2.07987405
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.07578401
168pericardium development (GO:0060039)2.06443779
169regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.06378403
170protein heterotrimerization (GO:0070208)2.06346402
171negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.06181601
172negative regulation of cell aging (GO:0090344)2.05001653
173regulation of mitochondrial fission (GO:0090140)2.04773277
174negative regulation of axon extension (GO:0030517)2.04268468
175mannosylation (GO:0097502)2.03244431
176Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.02879386
177positive regulation of male gonad development (GO:2000020)2.02422553
178response to redox state (GO:0051775)2.01330380
179endocardial cushion development (GO:0003197)2.01181144
180negative regulation of JAK-STAT cascade (GO:0046426)2.01111278
181positive regulation of synapse assembly (GO:0051965)2.00549371
182embryonic foregut morphogenesis (GO:0048617)2.00369421
183sympathetic nervous system development (GO:0048485)2.00349110
184cell proliferation in forebrain (GO:0021846)2.00257710
185cellular response to vitamin (GO:0071295)2.00144832
186G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.00098809
187mesenchymal-epithelial cell signaling (GO:0060638)1.99360862
188embryonic forelimb morphogenesis (GO:0035115)1.98840356
189retinal cone cell development (GO:0046549)1.97159122
190cilium organization (GO:0044782)1.97047236
191cilium assembly (GO:0042384)1.96454784
192ephrin receptor signaling pathway (GO:0048013)1.96399456
193peristalsis (GO:0030432)1.96082672
194bone trabecula formation (GO:0060346)1.94531076
195artery development (GO:0060840)1.92957496
196regulation of establishment of planar polarity (GO:0090175)1.92434263
197skin morphogenesis (GO:0043589)1.91935900
198limb development (GO:0060173)1.91555983
199appendage development (GO:0048736)1.91555983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.15094747
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.34043887
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.97055993
4SCL_19346495_ChIP-Seq_HPC-7_Human3.69610848
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.48273458
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.42771076
7ZNF274_21170338_ChIP-Seq_K562_Hela3.40932110
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10735459
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99144675
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.77744006
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.75325554
12GBX2_23144817_ChIP-Seq_PC3_Human2.60614094
13MYC_22102868_ChIP-Seq_BL_Human2.59812676
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49940824
15GATA1_22025678_ChIP-Seq_K562_Human2.46693846
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.40159982
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.32743894
18E2F7_22180533_ChIP-Seq_HELA_Human2.23420926
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17865029
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15697660
21ZNF263_19887448_ChIP-Seq_K562_Human2.13800442
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08580153
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05569677
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04889297
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.96356150
26CJUN_26792858_Chip-Seq_BT549_Human1.88949343
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85178785
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83907352
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83112496
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80566250
31TCF7_22412390_ChIP-Seq_EML_Mouse1.74024918
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.72028340
33ELK1_19687146_ChIP-ChIP_HELA_Human1.71675213
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67980596
35BRD4_25478319_ChIP-Seq_HGPS_Human1.66347546
36TP53_18474530_ChIP-ChIP_U2OS_Human1.64421839
37EWS_26573619_Chip-Seq_HEK293_Human1.58888671
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.57575080
39CLOCK_20551151_ChIP-Seq_293T_Human1.54046439
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53901920
41IGF1R_20145208_ChIP-Seq_DFB_Human1.53410973
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53026862
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53010063
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.52929075
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52550302
46VDR_21846776_ChIP-Seq_THP-1_Human1.52117436
47AHR_22903824_ChIP-Seq_MCF-7_Human1.52106081
48TP53_16413492_ChIP-PET_HCT116_Human1.51330067
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51242128
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50727559
51FUS_26573619_Chip-Seq_HEK293_Human1.49729473
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48722672
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48722672
54VDR_22108803_ChIP-Seq_LS180_Human1.48260612
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47698253
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46589611
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45276705
58TAF15_26573619_Chip-Seq_HEK293_Human1.44769939
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42763094
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42296377
61P300_19829295_ChIP-Seq_ESCs_Human1.41075049
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.38930379
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38322865
64LXR_22292898_ChIP-Seq_THP-1_Human1.37476101
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36866148
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35078105
67GATA1_19941826_ChIP-Seq_K562_Human1.34683548
68IRF1_19129219_ChIP-ChIP_H3396_Human1.34278313
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34203612
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33258205
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32910866
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32905083
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.32786353
74UTX_26944678_Chip-Seq_JUKART_Human1.32649168
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31901353
76SMAD4_21799915_ChIP-Seq_A2780_Human1.31728164
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29423933
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29286437
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.29243493
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.28476184
81KDM2B_26808549_Chip-Seq_DND41_Human1.27539388
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27298327
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26925316
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26169558
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25728136
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25245333
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25170702
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.22548704
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21058085
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20745042
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20611430
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.20368452
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19440379
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.19282570
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16270996
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.15971155
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14550278
98AR_25329375_ChIP-Seq_VCAP_Human1.14006430
99MYC_18940864_ChIP-ChIP_HL60_Human1.13054396
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12634051
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12528621
102P68_20966046_ChIP-Seq_HELA_Human1.12104039
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11806509
104STAT3_23295773_ChIP-Seq_U87_Human1.11791779
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11618776
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.11386585
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10823720
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09760334
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09760334
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09562867
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09488850
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08683744
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07822854
114MAF_26560356_Chip-Seq_TH1_Human1.07700129
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07676158
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07598411
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07502459
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07343568
119NCOR1_26117541_ChIP-Seq_K562_Human1.07335568
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07319186
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.06637870
122RACK7_27058665_Chip-Seq_MCF-7_Human1.06521075
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05975486
124CBX2_27304074_Chip-Seq_ESCs_Mouse1.04677591
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04589712
126EP300_21415370_ChIP-Seq_HL-1_Mouse1.04248188
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03917639
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03462066
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.03283162
130BCOR_27268052_Chip-Seq_Bcells_Human1.03161754
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02997183
132CIITA_25753668_ChIP-Seq_RAJI_Human1.02032896
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01778489
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01746940
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01639389
136GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01583400
137TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01294492
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01063548
139KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00422462
140MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00200519
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99993936
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99747503
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99498570
144FOXM1_23109430_ChIP-Seq_U2OS_Human0.98482119
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98476744
146CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98285642
147ER_23166858_ChIP-Seq_MCF-7_Human0.97918689
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97662473
149ATF3_27146783_Chip-Seq_COLON_Human0.97255604
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97200893
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97150916
152SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96828568
153IRF8_22096565_ChIP-ChIP_GC-B_Human0.96759218
154ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96631038
155MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96390182
156CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96388080
157TP53_22127205_ChIP-Seq_IMR90_Human0.96208626
158TP63_23658742_ChIP-Seq_EP156T_Human0.96062827
159BCL6_27268052_Chip-Seq_Bcells_Human0.95874329
160IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95410327
161CBP_20019798_ChIP-Seq_JUKART_Human0.95410327
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95069872
163PHF8_20622854_ChIP-Seq_HELA_Human0.95062049
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.94680824
165FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94541366
166FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93690208
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93595972
168SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93523816
169CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93515631
170CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92752705
171P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92692205
172KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91721196
173WT1_19549856_ChIP-ChIP_CCG9911_Human0.91524872
174STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90152336
175PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89357677
176ETS1_20019798_ChIP-Seq_JURKAT_Human0.88733578
177JUN_21703547_ChIP-Seq_K562_Human0.88278389
178UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87889431
179TCF4_22108803_ChIP-Seq_LS180_Human0.87884713
180RUNX2_22187159_ChIP-Seq_PCA_Human0.87759518
181MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87488820
182SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87438128
183SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86575335
184PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86205202
185SOX2_16153702_ChIP-ChIP_HESCs_Human0.86120477
186TP63_19390658_ChIP-ChIP_HaCaT_Human0.86016488
187KDM5A_27292631_Chip-Seq_BREAST_Human0.85635038
188CTCF_21964334_Chip-Seq_Bcells_Human0.85522643
189GATA2_19941826_ChIP-Seq_K562_Human0.85483541
190FOXA2_19822575_ChIP-Seq_HepG2_Human0.85099175
191SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84996562
192POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84895335
193SPI1_20517297_ChIP-Seq_HL60_Human0.84869192
194KDM2B_26808549_Chip-Seq_JURKAT_Human0.84102651
195CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83534324
196TET1_21451524_ChIP-Seq_MESCs_Mouse0.83260532
197P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82548860
198HNF4A_19822575_ChIP-Seq_HepG2_Human0.80947610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.12504711
2MP0003283_abnormal_digestive_organ4.75130300
3MP0005365_abnormal_bile_salt4.38283543
4MP0005360_urolithiasis4.18672239
5MP0005085_abnormal_gallbladder_physiolo3.83921257
6MP0003252_abnormal_bile_duct3.35464830
7MP0000579_abnormal_nail_morphology3.27611172
8MP0003806_abnormal_nucleotide_metabolis3.25967693
9MP0003705_abnormal_hypodermis_morpholog3.06895762
10MP0010329_abnormal_lipoprotein_level2.95876980
11MP0003941_abnormal_skin_development2.84048785
12MP0003191_abnormal_cellular_cholesterol2.82101586
13MP0002234_abnormal_pharynx_morphology2.72732031
14MP0010030_abnormal_orbit_morphology2.45187095
15MP0009840_abnormal_foam_cell2.43157874
16MP0004272_abnormal_basement_membrane2.39448428
17MP0005623_abnormal_meninges_morphology2.32765623
18MP0003950_abnormal_plasma_membrane2.24493082
19MP0008875_abnormal_xenobiotic_pharmacok2.22013803
20MP0006054_spinal_hemorrhage2.17161433
21MP0000427_abnormal_hair_cycle2.01536467
22MP0009053_abnormal_anal_canal2.00436622
23MP0000762_abnormal_tongue_morphology1.97983167
24MP0008438_abnormal_cutaneous_collagen1.96585196
25MP0010352_gastrointestinal_tract_polyps1.94014645
26MP0005083_abnormal_biliary_tract1.92958501
27MP0003011_delayed_dark_adaptation1.88376168
28MP0005397_hematopoietic_system_phenotyp1.87314250
29MP0001545_abnormal_hematopoietic_system1.87314250
30MP0001299_abnormal_eye_distance/1.87121358
31MP0002938_white_spotting1.84766987
32MP0005220_abnormal_exocrine_pancreas1.84703993
33MP0003755_abnormal_palate_morphology1.83554490
34MP0001529_abnormal_vocalization1.82920364
35MP0004808_abnormal_hematopoietic_stem1.82917450
36MP0003937_abnormal_limbs/digits/tail_de1.79422887
37MP0009384_cardiac_valve_regurgitation1.77668734
38MP0003868_abnormal_feces_composition1.74699643
39MP0000467_abnormal_esophagus_morphology1.74231107
40MP0005319_abnormal_enzyme/_coenzyme1.67991375
41MP0000383_abnormal_hair_follicle1.67183839
42MP0003172_abnormal_lysosome_physiology1.65334816
43MP0006292_abnormal_olfactory_placode1.65021037
44MP0000647_abnormal_sebaceous_gland1.64910324
45MP0000569_abnormal_digit_pigmentation1.62865208
46MP0000609_abnormal_liver_physiology1.60256978
47MP0004264_abnormal_extraembryonic_tissu1.56621703
48MP0005275_abnormal_skin_tensile1.54795910
49MP0008789_abnormal_olfactory_epithelium1.54681099
50MP0004084_abnormal_cardiac_muscle1.53023088
51MP0002102_abnormal_ear_morphology1.52508855
52MP0005464_abnormal_platelet_physiology1.51426012
53MP0001764_abnormal_homeostasis1.50020828
54MP0005257_abnormal_intraocular_pressure1.48680024
55MP0010678_abnormal_skin_adnexa1.48023769
56MP0002282_abnormal_trachea_morphology1.45900083
57MP0009780_abnormal_chondrocyte_physiolo1.44763894
58MP0000598_abnormal_liver_morphology1.44587957
59MP0001666_abnormal_nutrient_absorption1.44500305
60MP0002396_abnormal_hematopoietic_system1.43453533
61MP0002118_abnormal_lipid_homeostasis1.42954181
62MP0008058_abnormal_DNA_repair1.41834738
63MP0000537_abnormal_urethra_morphology1.36779715
64MP0002098_abnormal_vibrissa_morphology1.36346898
65MP0000778_abnormal_nervous_system1.33849410
66MP0002233_abnormal_nose_morphology1.33047627
67MP0002060_abnormal_skin_morphology1.32693185
68MP0003787_abnormal_imprinting1.32238513
69MP0000049_abnormal_middle_ear1.28479450
70MP0000538_abnormal_urinary_bladder1.26775596
71MP0009250_abnormal_appendicular_skeleto1.25590645
72MP0003942_abnormal_urinary_system1.25587540
73MP0002653_abnormal_ependyma_morphology1.25556928
74MP0005499_abnormal_olfactory_system1.25423148
75MP0005394_taste/olfaction_phenotype1.25423148
76MP0000534_abnormal_ureter_morphology1.25418115
77MP0000747_muscle_weakness1.24584013
78MP0003315_abnormal_perineum_morphology1.23471672
79MP0005501_abnormal_skin_physiology1.20717231
80MP0000566_synostosis1.19698940
81MP0003656_abnormal_erythrocyte_physiolo1.19282858
82MP0004130_abnormal_muscle_cell1.18935970
83MP0005332_abnormal_amino_acid1.18759970
84MP0008877_abnormal_DNA_methylation1.14396284
85MP0002909_abnormal_adrenal_gland1.11159145
86MP0001324_abnormal_eye_pigmentation1.10976996
87MP0002796_impaired_skin_barrier1.10252100
88MP0003119_abnormal_digestive_system1.10233357
89MP0000604_amyloidosis1.09966325
90MP0010771_integument_phenotype1.09115191
91MP0000013_abnormal_adipose_tissue1.08992969
92MP0002177_abnormal_outer_ear1.08908729
93MP0001286_abnormal_eye_development1.08767437
94MP0003935_abnormal_craniofacial_develop1.07404922
95MP0000465_gastrointestinal_hemorrhage1.06408111
96MP0003385_abnormal_body_wall1.05718960
97MP0002697_abnormal_eye_size1.05244421
98MP0002837_dystrophic_cardiac_calcinosis1.04703174
99MP0001216_abnormal_epidermal_layer1.04186731
100MP0003943_abnormal_hepatobiliary_system1.04054871
101MP0001958_emphysema1.03604099
102MP0003718_maternal_effect1.03168842
103MP0003136_yellow_coat_color1.01967623
104MP0003566_abnormal_cell_adhesion1.01752140
105MP0005503_abnormal_tendon_morphology1.00927007
106MP0010386_abnormal_urinary_bladder1.00651808
107MP0002269_muscular_atrophy1.00578424
108MP0004043_abnormal_pH_regulation0.98001173
109MP0002928_abnormal_bile_duct0.97318325
110MP0002751_abnormal_autonomic_nervous0.96888570
111MP0001984_abnormal_olfaction0.95131453
112MP0005171_absent_coat_pigmentation0.94082645
113MP0005058_abnormal_lysosome_morphology0.93072014
114MP0003300_gastrointestinal_ulcer0.92237880
115MP0005584_abnormal_enzyme/coenzyme_acti0.92160681
116MP0005197_abnormal_uvea_morphology0.91940282
117MP0003329_amyloid_beta_deposits0.91060938
118MP0000432_abnormal_head_morphology0.89744945
119MP0009643_abnormal_urine_homeostasis0.89332567
120MP0005084_abnormal_gallbladder_morpholo0.88718309
121MP0002109_abnormal_limb_morphology0.88548674
122MP0002116_abnormal_craniofacial_bone0.88303500
123MP0006072_abnormal_retinal_apoptosis0.87587223
124MP0005248_abnormal_Harderian_gland0.87140197
125MP0002111_abnormal_tail_morphology0.86322874
126MP0009763_increased_sensitivity_to0.84131116
127MP0005551_abnormal_eye_electrophysiolog0.83929571
128MP0003861_abnormal_nervous_system0.83702576
129MP0008932_abnormal_embryonic_tissue0.83150816
130MP0006276_abnormal_autonomic_nervous0.81844582
131MP0005508_abnormal_skeleton_morphology0.81499594
132MP0004133_heterotaxia0.81240307
133MP0000751_myopathy0.80569476
134MP0003221_abnormal_cardiomyocyte_apopto0.79877890
135MP0010368_abnormal_lymphatic_system0.79847955
136MP0005187_abnormal_penis_morphology0.78184814
137MP0001944_abnormal_pancreas_morphology0.78093589
138MP0003890_abnormal_embryonic-extraembry0.77825702
139MP0003279_aneurysm0.77202514
140MP0001849_ear_inflammation0.77131322
141MP0000377_abnormal_hair_follicle0.77130637
142MP0002160_abnormal_reproductive_system0.76507959
143MP0005330_cardiomyopathy0.75733537
144MP0004036_abnormal_muscle_relaxation0.75232089
145MP0002084_abnormal_developmental_patter0.74889457
146MP0008007_abnormal_cellular_replicative0.74716459
147MP0002092_abnormal_eye_morphology0.73895928
148MP0005367_renal/urinary_system_phenotyp0.73579969
149MP0000516_abnormal_urinary_system0.73579969
150MP0002932_abnormal_joint_morphology0.73055225
151MP0001340_abnormal_eyelid_morphology0.72981989
152MP0005391_vision/eye_phenotype0.72883302
153MP0003122_maternal_imprinting0.71660014
154MP0001293_anophthalmia0.71269143
155MP0003567_abnormal_fetal_cardiomyocyte0.71211665
156MP0000163_abnormal_cartilage_morphology0.70968634
157MP0005195_abnormal_posterior_eye0.70520345
158MP0002295_abnormal_pulmonary_circulatio0.70291299
159MP0005023_abnormal_wound_healing0.69649274
160MP0009764_decreased_sensitivity_to0.68119653
161MP0000689_abnormal_spleen_morphology0.68044260
162MP0009278_abnormal_bone_marrow0.67682619
163MP0002078_abnormal_glucose_homeostasis0.67510899
164MP0009672_abnormal_birth_weight0.67495188
165MP0002896_abnormal_bone_mineralization0.66424978
166MP0005647_abnormal_sex_gland0.66223823
167MP0002089_abnormal_postnatal_growth/wei0.66213298
168MP0008775_abnormal_heart_ventricle0.66010092
169MP0000358_abnormal_cell_content/0.64577885
170MP0008469_abnormal_protein_level0.64562135
171MP0002086_abnormal_extraembryonic_tissu0.63952474
172MP0002080_prenatal_lethality0.63735788
173MP0004510_myositis0.63354717
174MP0010630_abnormal_cardiac_muscle0.63318281
175MP0009642_abnormal_blood_homeostasis0.62887071
176MP0005666_abnormal_adipose_tissue0.62765557
177MP0000477_abnormal_intestine_morphology0.61078685
178MP0005636_abnormal_mineral_homeostasis0.59592315
179MP0002019_abnormal_tumor_incidence0.57725611
180MP0000490_abnormal_crypts_of0.57363830
181MP0003195_calcinosis0.56645360
182MP0005165_increased_susceptibility_to0.56620022
183MP0005385_cardiovascular_system_phenoty0.56353574
184MP0001544_abnormal_cardiovascular_syste0.56353574
185MP0008873_increased_physiological_sensi0.53962500
186MP0004147_increased_porphyrin_level0.53828183
187MP0002135_abnormal_kidney_morphology0.53173669
188MP0002254_reproductive_system_inflammat0.52601726
189MP0010234_abnormal_vibrissa_follicle0.52149734

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.69202455
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.18722926
3Xanthomatosis (HP:0000991)4.09196718
4Intrahepatic cholestasis (HP:0001406)4.00161261
5Back pain (HP:0003418)3.97030450
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.95999681
7Hyperlipoproteinemia (HP:0010980)3.93928688
8Ketosis (HP:0001946)3.72035446
9Hypobetalipoproteinemia (HP:0003563)3.66362613
10Hyperammonemia (HP:0001987)3.59307831
11Sensorimotor neuropathy (HP:0007141)3.53221168
12Ketoacidosis (HP:0001993)3.50362652
13Atrophic scars (HP:0001075)3.41453625
14Fragile nails (HP:0001808)3.20639175
15Abnormality of the thoracic spine (HP:0100711)3.17370295
16Hypoglycemic coma (HP:0001325)3.16208403
17Global brain atrophy (HP:0002283)3.13838987
18Milia (HP:0001056)3.02495843
19Abnormality of pyrimidine metabolism (HP:0004353)3.01263948
20Abnormality of fatty-acid metabolism (HP:0004359)2.99146655
21Nasal polyposis (HP:0100582)2.98116341
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92890522
23Abnormality of the nasal mucosa (HP:0000433)2.90310750
24Cone-rod dystrophy (HP:0000548)2.88469328
25True hermaphroditism (HP:0010459)2.86146240
26Molar tooth sign on MRI (HP:0002419)2.84790407
27Abnormality of midbrain morphology (HP:0002418)2.84790407
28Onycholysis (HP:0001806)2.80773353
29Premature rupture of membranes (HP:0001788)2.80045518
30Follicular hyperkeratosis (HP:0007502)2.79901932
31Menorrhagia (HP:0000132)2.78566309
32Pancreatic cysts (HP:0001737)2.76249018
33Hypolipoproteinemia (HP:0010981)2.76171641
34Reduced subcutaneous adipose tissue (HP:0003758)2.74164806
35Pancreatic fibrosis (HP:0100732)2.71051439
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70934147
37Neonatal onset (HP:0003623)2.70617827
38Plantar hyperkeratosis (HP:0007556)2.62323897
39Prolonged partial thromboplastin time (HP:0003645)2.57169165
40Spastic diplegia (HP:0001264)2.55729746
41Asymmetric septal hypertrophy (HP:0001670)2.54840127
42Dry hair (HP:0011359)2.53628377
43Dicarboxylic aciduria (HP:0003215)2.51650315
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51650315
45Male infertility (HP:0003251)2.51476815
46Abnormal platelet function (HP:0011869)2.51281764
47Impaired platelet aggregation (HP:0003540)2.51281764
48Abnormality of the common coagulation pathway (HP:0010990)2.47495924
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46729184
50Pigmentary retinal degeneration (HP:0001146)2.44125322
51Nephronophthisis (HP:0000090)2.40326118
52Urinary glycosaminoglycan excretion (HP:0003541)2.39629694
53Mucopolysacchariduria (HP:0008155)2.39629694
54Increased cerebral lipofuscin (HP:0011813)2.39134487
55Hypercholesterolemia (HP:0003124)2.36966940
56Hypoalphalipoproteinemia (HP:0003233)2.35460436
57Prolonged bleeding time (HP:0003010)2.35346470
58Rhabdomyolysis (HP:0003201)2.34419821
59Progressive muscle weakness (HP:0003323)2.33613200
60Pendular nystagmus (HP:0012043)2.33521345
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.30411042
62Natal tooth (HP:0000695)2.30359311
63Medial flaring of the eyebrow (HP:0010747)2.30200862
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29916915
65Type II lissencephaly (HP:0007260)2.29850997
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.28662054
67Abnormality of nail color (HP:0100643)2.25120195
68Gingival bleeding (HP:0000225)2.23025335
69Fat malabsorption (HP:0002630)2.22413239
70Abnormality of serum amino acid levels (HP:0003112)2.22229827
71Hyperglycinuria (HP:0003108)2.22193886
72Cerebellar dysplasia (HP:0007033)2.19780827
73Alopecia of scalp (HP:0002293)2.19553902
74Petechiae (HP:0000967)2.19418012
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18899096
76Abnormality of polysaccharide metabolism (HP:0011012)2.18899096
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18899096
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18864685
79Congenital primary aphakia (HP:0007707)2.17565280
80Abnormality of serine family amino acid metabolism (HP:0010894)2.17352884
81Abnormality of glycine metabolism (HP:0010895)2.17352884
82Metabolic acidosis (HP:0001942)2.16132415
83Thoracic kyphosis (HP:0002942)2.15154039
84Gait imbalance (HP:0002141)2.13393456
85Epistaxis (HP:0000421)2.13315143
86Abnormality of nucleobase metabolism (HP:0010932)2.12412227
87Myoglobinuria (HP:0002913)2.12388921
88Hepatocellular carcinoma (HP:0001402)2.11332958
89Lissencephaly (HP:0001339)2.09967772
90Abnormality of the renal medulla (HP:0100957)2.09657262
91Thick nail (HP:0001805)2.09623552
92Abnormality of macular pigmentation (HP:0008002)2.09218862
93Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08694772
94Hypoplasia of the pons (HP:0012110)2.08211368
95Abnormality of glutamine family amino acid metabolism (HP:0010902)2.07302516
96Tubular atrophy (HP:0000092)2.06616985
97Aplasia/Hypoplasia of the tongue (HP:0010295)2.06245839
98Short nail (HP:0001799)2.05109132
99Pelvic girdle muscle weakness (HP:0003749)2.03222715
100Rimmed vacuoles (HP:0003805)2.03017754
101Disproportionate short-trunk short stature (HP:0003521)2.02157271
102Hyperbilirubinemia (HP:0002904)2.00973913
103Delayed gross motor development (HP:0002194)2.00738013
104Concave nail (HP:0001598)1.99315173
105Nephrogenic diabetes insipidus (HP:0009806)1.99180779
106Complement deficiency (HP:0004431)1.98823368
107CNS demyelination (HP:0007305)1.98139865
108Abnormality of dentin (HP:0010299)1.96869750
109Severe visual impairment (HP:0001141)1.96803743
110Hypoplastic pelvis (HP:0008839)1.95586335
111Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95538969
112Palpitations (HP:0001962)1.95338909
113Decreased central vision (HP:0007663)1.94709179
114Hypoplastic labia majora (HP:0000059)1.94547475
115Palmar hyperkeratosis (HP:0010765)1.93287351
116Long toe (HP:0010511)1.92847058
117Ragged-red muscle fibers (HP:0003200)1.92822651
118Sclerocornea (HP:0000647)1.92711581
119Palmoplantar hyperkeratosis (HP:0000972)1.92680360
120Nail dystrophy (HP:0008404)1.92433286
121Acanthocytosis (HP:0001927)1.92191265
122Neonatal respiratory distress (HP:0002643)1.92035586
123Abnormality of the pons (HP:0007361)1.91037409
124Cystic liver disease (HP:0006706)1.90919126
125Insulin resistance (HP:0000855)1.90738406
126Delayed CNS myelination (HP:0002188)1.90143433
127Gout (HP:0001997)1.89718131
128Abnormality of the intrinsic pathway (HP:0010989)1.89259250
129Centrally nucleated skeletal muscle fibers (HP:0003687)1.88883581
130Increased mean platelet volume (HP:0011877)1.88236044
131Short palpebral fissure (HP:0012745)1.87411677
132Morphological abnormality of the middle ear (HP:0008609)1.87302042
133Epidermoid cyst (HP:0200040)1.87000237
134Joint hemorrhage (HP:0005261)1.86374350
135Entropion (HP:0000621)1.86321538
136Polycythemia (HP:0001901)1.86303762
137Poikiloderma (HP:0001029)1.85601010
138Bifid tongue (HP:0010297)1.84885113
139Abnormality of the pancreatic islet cells (HP:0006476)1.84442636
140Abnormality of endocrine pancreas physiology (HP:0012093)1.84442636
141Hyperinsulinemic hypoglycemia (HP:0000825)1.84215316
142Hypoglycemic seizures (HP:0002173)1.84065047
143Cervical subluxation (HP:0003308)1.83866631
144Fragile skin (HP:0001030)1.82482930
145Abnormality of lateral ventricle (HP:0030047)1.82172741
146Abnormal platelet volume (HP:0011876)1.81776030
147Anophthalmia (HP:0000528)1.81740781
148Hypodontia (HP:0000668)1.81202538
149Chorioretinal atrophy (HP:0000533)1.80388224
150Vaginal atresia (HP:0000148)1.80280650
151Bony spicule pigmentary retinopathy (HP:0007737)1.80277399
152Postaxial hand polydactyly (HP:0001162)1.79242382
153Bilateral microphthalmos (HP:0007633)1.79108806
154Genital tract atresia (HP:0001827)1.78611673
155Soft skin (HP:0000977)1.78547422
156Labial hypoplasia (HP:0000066)1.76745525
157Abnormality of the labia majora (HP:0012881)1.75276814
158Optic nerve hypoplasia (HP:0000609)1.72505114
159Bladder diverticulum (HP:0000015)1.69738547
160Fibular aplasia (HP:0002990)1.69641058
161Breast hypoplasia (HP:0003187)1.69555359
162Postaxial foot polydactyly (HP:0001830)1.69321845
163Pterygium (HP:0001059)1.69258736
164Neonatal short-limb short stature (HP:0008921)1.68651849
165Keratoconus (HP:0000563)1.67771767
166Increased corneal curvature (HP:0100692)1.67771767
167Hypoplastic female external genitalia (HP:0012815)1.67300246
168Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.63943907
169Hand muscle atrophy (HP:0009130)1.62268924
170Congenital, generalized hypertrichosis (HP:0004540)1.62051463
171Selective tooth agenesis (HP:0001592)1.62044025
172Small hand (HP:0200055)1.61878024
173Retinal dysplasia (HP:0007973)1.59457377
174Coronal craniosynostosis (HP:0004440)1.59446554
175Hyperventilation (HP:0002883)1.59261352
176Pachygyria (HP:0001302)1.57450424
177Sparse eyelashes (HP:0000653)1.56685908
178Protrusio acetabuli (HP:0003179)1.55835215
179Abnormal hair laboratory examination (HP:0003328)1.55714041
180Preaxial hand polydactyly (HP:0001177)1.55035497
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.54858763
182Furrowed tongue (HP:0000221)1.54563407
183Adrenal hypoplasia (HP:0000835)1.54439248
184Amelogenesis imperfecta (HP:0000705)1.54422995
185Aplasia/Hypoplasia of the fibula (HP:0006492)1.53802306
186Severe muscular hypotonia (HP:0006829)1.53702336
187Woolly hair (HP:0002224)1.53079746
188Aplasia/hypoplasia of the uterus (HP:0008684)1.53004411
189Ankle contracture (HP:0006466)1.52527121
190Aplasia/Hypoplasia of the lens (HP:0008063)1.51602322
191Hypoventilation (HP:0002791)1.51199623
192Hypoplasia of the uterus (HP:0000013)1.50292939
193Aplasia/Hypoplasia of the tibia (HP:0005772)1.49485737
194Increased number of teeth (HP:0011069)1.47527342
195Short foot (HP:0001773)1.45021251
196Chronic hepatic failure (HP:0100626)1.43901774
197Aplasia/Hypoplasia of the patella (HP:0006498)1.43274889
198Anencephaly (HP:0002323)1.42603791

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.19327742
2PKN24.15125145
3EEF2K3.98861807
4BRD43.58824285
5MAPK153.37608739
6TRIB33.25093528
7ERBB33.17864757
8MST1R3.03640760
9MET2.90731489
10EPHB22.78466157
11FRK2.59682002
12BCR2.47337019
13KSR22.44700296
14BMPR1B2.35721096
15SCYL22.33905356
16BLK2.31861817
17MAP3K22.29321163
18LIMK12.27512691
19INSRR2.25941964
20LATS12.22116241
21FLT32.16332044
22CASK2.09835394
23PTK22.07823245
24STK38L1.92970354
25BCKDK1.89094273
26TTN1.88944859
27PNCK1.82455832
28RPS6KB21.72985616
29AKT31.71132907
30TNK21.70916406
31MAP2K71.70482438
32WNK31.69862767
33TRIM281.66097664
34PASK1.65934028
35MYLK1.65213499
36EPHA21.63844873
37ADRBK21.59078061
38MARK11.53220276
39ERN11.50255100
40LRRK21.49555102
41PBK1.49252368
42TGFBR11.48873796
43PRKCH1.46854233
44ZAP701.45096500
45NEK21.43447209
46PTK61.40421345
47RAF11.39037121
48NUAK11.36157739
49NEK11.34792822
50WNK41.33686031
51GRK11.30865803
52MAP3K121.29463716
53PDK31.26704797
54PDK41.26704797
55FER1.25899744
56ZAK1.24802244
57SIK11.24733091
58RET1.23937307
59EPHA31.23543037
60CDK191.22713976
61ERBB41.22562481
62PRKD21.20923903
63MAP2K31.19604780
64ADRBK11.19028901
65PRKCE1.16990388
66MAP3K101.16986155
67BUB11.15498490
68CSNK1A1L1.10592788
69BMPR21.08915324
70FGFR41.08372762
71STK381.07173879
72MAP3K41.07093757
73MAP3K61.06853451
74CSF1R1.05675839
75TLK11.05165190
76MAP4K21.03596098
77MAPKAPK31.01931992
78MAP4K10.98526217
79PLK20.97145952
80PTK2B0.94811381
81NME10.93725453
82JAK20.91829853
83TGFBR20.91708558
84STK100.91578141
85TSSK60.91059018
86CDK80.89849667
87CSNK1G10.89781478
88DYRK20.89176873
89TYK20.88989930
90VRK20.88916393
91TBK10.88561162
92PDGFRA0.88480153
93CSNK1G30.87889188
94PAK30.84976189
95KIT0.82360524
96MST40.81641316
97LMTK20.81603287
98STK30.78787469
99NTRK30.73400655
100PRKCI0.72686806
101BTK0.72485866
102PIM20.72254497
103MATK0.71641889
104MUSK0.66795501
105CSNK1G20.64884689
106MTOR0.64433501
107NME20.63651636
108PLK30.62976717
109MAP3K80.61948543
110PAK40.61667660
111PLK10.61236468
112STK160.61146189
113GSK3A0.59897853
114MAP2K10.58949540
115CDK60.58347602
116EPHB10.57793596
117MAP3K10.57477804
118PINK10.56037164
119STK390.55758815
120WEE10.55617332
121DYRK30.55058950
122TNIK0.54951521
123VRK10.54906697
124ROCK10.54391825
125MAP2K60.52835929
126MAPK130.52723647
127MAP3K90.50663639
128NEK90.48120202
129CDK40.46644969
130PRKCG0.46073699
131OXSR10.42785851
132MAP2K40.42139613
133SRPK10.42089255
134KDR0.41805787
135TESK10.41690302
136AURKB0.41469750
137PHKG20.39847891
138PHKG10.39847891
139MKNK20.39666380
140PIK3CA0.39648046
141CHEK20.38906704
142SIK30.38130570
143PDK10.37822518
144MAPK110.37319313
145SYK0.37308174
146KSR10.37132258
147LATS20.36700293
148HIPK20.35638421
149MELK0.35501763
150JAK30.35433908
151PIM10.35430892
152PAK20.35314253
153GRK60.35299382
154CHUK0.34639204
155MAP3K50.34491458
156ABL20.33547899
157CSNK1A10.33522581
158TAOK30.33486376
159HCK0.30232028
160CDK120.28109762
161JAK10.28007032
162ACVR1B0.27384968
163MAPK40.24916788
164PDPK10.24478645
165ALK0.24079285
166MAP3K110.23497774
167TTK0.22792736
168CSK0.22751060
169BMX0.22294652
170CAMKK10.21473915
171TAOK10.21280006
172BRSK20.20160370
173MAPK70.20091281
174PRKG20.18735794
175NTRK10.17188115

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.53022256
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12710857
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.94619784
4Fatty acid degradation_Homo sapiens_hsa000712.92516961
5Nitrogen metabolism_Homo sapiens_hsa009102.89921116
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82639309
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68226911
8Arginine biosynthesis_Homo sapiens_hsa002202.67104111
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.66210984
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.61671807
11Butanoate metabolism_Homo sapiens_hsa006502.59694800
12Propanoate metabolism_Homo sapiens_hsa006402.31355453
13Tryptophan metabolism_Homo sapiens_hsa003802.26221998
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19251525
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18590861
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11817092
17Steroid biosynthesis_Homo sapiens_hsa001002.09410129
18Protein export_Homo sapiens_hsa030602.02459719
19Pyruvate metabolism_Homo sapiens_hsa006202.02093998
20Caffeine metabolism_Homo sapiens_hsa002322.01669854
21Selenocompound metabolism_Homo sapiens_hsa004502.01177811
22ECM-receptor interaction_Homo sapiens_hsa045121.99278897
23Hippo signaling pathway_Homo sapiens_hsa043901.97475129
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.96917434
25Basal cell carcinoma_Homo sapiens_hsa052171.93042118
26Hedgehog signaling pathway_Homo sapiens_hsa043401.92672458
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.90045066
28Peroxisome_Homo sapiens_hsa041461.88517902
29Biosynthesis of amino acids_Homo sapiens_hsa012301.84289412
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82950447
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.77819638
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75054710
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.72992625
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72617446
35Carbon metabolism_Homo sapiens_hsa012001.71567006
36RNA polymerase_Homo sapiens_hsa030201.67920230
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66135757
38Axon guidance_Homo sapiens_hsa043601.65919887
39Fatty acid metabolism_Homo sapiens_hsa012121.63124091
40Complement and coagulation cascades_Homo sapiens_hsa046101.60240787
41Basal transcription factors_Homo sapiens_hsa030221.51651412
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45344010
43beta-Alanine metabolism_Homo sapiens_hsa004101.42916512
44Proteasome_Homo sapiens_hsa030501.39766301
45Phototransduction_Homo sapiens_hsa047441.37741603
46PPAR signaling pathway_Homo sapiens_hsa033201.37082075
47Sulfur relay system_Homo sapiens_hsa041221.35950766
48Fanconi anemia pathway_Homo sapiens_hsa034601.31575436
49ABC transporters_Homo sapiens_hsa020101.28656941
50Lysine degradation_Homo sapiens_hsa003101.21291326
51Sulfur metabolism_Homo sapiens_hsa009201.18185099
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18145710
53Histidine metabolism_Homo sapiens_hsa003401.17584391
54Bile secretion_Homo sapiens_hsa049761.17479904
55Dorso-ventral axis formation_Homo sapiens_hsa043201.17371009
56Oxidative phosphorylation_Homo sapiens_hsa001901.12641126
57Notch signaling pathway_Homo sapiens_hsa043301.11060321
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10193510
59p53 signaling pathway_Homo sapiens_hsa041151.08305218
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08072790
61Fat digestion and absorption_Homo sapiens_hsa049751.07586840
62Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07402054
63Homologous recombination_Homo sapiens_hsa034401.06534787
64TGF-beta signaling pathway_Homo sapiens_hsa043501.04529941
65Adherens junction_Homo sapiens_hsa045201.03138943
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.01928020
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01347437
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00933881
69Focal adhesion_Homo sapiens_hsa045101.00788972
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97936976
71One carbon pool by folate_Homo sapiens_hsa006700.97638301
72Acute myeloid leukemia_Homo sapiens_hsa052210.95741855
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94940923
74Taste transduction_Homo sapiens_hsa047420.93239569
75Arginine and proline metabolism_Homo sapiens_hsa003300.92264465
76Huntingtons disease_Homo sapiens_hsa050160.91964431
77Tight junction_Homo sapiens_hsa045300.91414814
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91110263
79Starch and sucrose metabolism_Homo sapiens_hsa005000.89771644
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88553814
81Nicotine addiction_Homo sapiens_hsa050330.88157688
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85837118
83Wnt signaling pathway_Homo sapiens_hsa043100.84953352
84Non-homologous end-joining_Homo sapiens_hsa034500.84649426
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82714197
86Fatty acid elongation_Homo sapiens_hsa000620.82098728
87Parkinsons disease_Homo sapiens_hsa050120.82083914
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.79621210
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76931756
90RNA degradation_Homo sapiens_hsa030180.74514592
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73304204
92Prolactin signaling pathway_Homo sapiens_hsa049170.72525886
93Dilated cardiomyopathy_Homo sapiens_hsa054140.71529884
94N-Glycan biosynthesis_Homo sapiens_hsa005100.71376034
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70815090
96Staphylococcus aureus infection_Homo sapiens_hsa051500.70239027
97Sphingolipid metabolism_Homo sapiens_hsa006000.68938028
98Chemical carcinogenesis_Homo sapiens_hsa052040.67832397
99RNA transport_Homo sapiens_hsa030130.67026154
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66885276
101Chronic myeloid leukemia_Homo sapiens_hsa052200.66114057
102Alzheimers disease_Homo sapiens_hsa050100.65199511
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.65080075
104Circadian rhythm_Homo sapiens_hsa047100.63440487
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61270541
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60730856
107Melanogenesis_Homo sapiens_hsa049160.60573151
108Retinol metabolism_Homo sapiens_hsa008300.60164869
109Phenylalanine metabolism_Homo sapiens_hsa003600.60090234
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58903745
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58516784
112Folate biosynthesis_Homo sapiens_hsa007900.58160073
113Insulin resistance_Homo sapiens_hsa049310.58102343
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.57957861
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57663932
116GABAergic synapse_Homo sapiens_hsa047270.57597753
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56882481
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56816026
119Protein digestion and absorption_Homo sapiens_hsa049740.55361829
120Melanoma_Homo sapiens_hsa052180.55157059
121Bladder cancer_Homo sapiens_hsa052190.54977239
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54885613
123Pentose phosphate pathway_Homo sapiens_hsa000300.54418494
124Pathways in cancer_Homo sapiens_hsa052000.54401055
125Ether lipid metabolism_Homo sapiens_hsa005650.54263620
126Non-small cell lung cancer_Homo sapiens_hsa052230.53268963
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51172907
128Insulin signaling pathway_Homo sapiens_hsa049100.50893387
129Olfactory transduction_Homo sapiens_hsa047400.49608757
130Linoleic acid metabolism_Homo sapiens_hsa005910.49564817
131Prion diseases_Homo sapiens_hsa050200.49193716
132Vibrio cholerae infection_Homo sapiens_hsa051100.48489821
133Glutathione metabolism_Homo sapiens_hsa004800.47623882
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.46201314
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45876525
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45527930
137Glycerolipid metabolism_Homo sapiens_hsa005610.44239826
138Cardiac muscle contraction_Homo sapiens_hsa042600.44125175
139Thyroid cancer_Homo sapiens_hsa052160.43120617
140Glucagon signaling pathway_Homo sapiens_hsa049220.42983515
141Galactose metabolism_Homo sapiens_hsa000520.42863520
142MicroRNAs in cancer_Homo sapiens_hsa052060.41791622
143Glutamatergic synapse_Homo sapiens_hsa047240.41656730
144Ovarian steroidogenesis_Homo sapiens_hsa049130.41087281
145Other glycan degradation_Homo sapiens_hsa005110.40650536
146Pyrimidine metabolism_Homo sapiens_hsa002400.40450346
147Tyrosine metabolism_Homo sapiens_hsa003500.39545592
148B cell receptor signaling pathway_Homo sapiens_hsa046620.36370796
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35819777
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34949936
151Endometrial cancer_Homo sapiens_hsa052130.34804919
152DNA replication_Homo sapiens_hsa030300.33762159
153Purine metabolism_Homo sapiens_hsa002300.31251526
154Metabolic pathways_Homo sapiens_hsa011000.30836039
155Platelet activation_Homo sapiens_hsa046110.29201155
156Vitamin B6 metabolism_Homo sapiens_hsa007500.28795015
157mTOR signaling pathway_Homo sapiens_hsa041500.27480768
158Steroid hormone biosynthesis_Homo sapiens_hsa001400.25840335
159AMPK signaling pathway_Homo sapiens_hsa041520.24475825
160HIF-1 signaling pathway_Homo sapiens_hsa040660.20896367
161Nucleotide excision repair_Homo sapiens_hsa034200.19788203
162Glioma_Homo sapiens_hsa052140.19196257
163FoxO signaling pathway_Homo sapiens_hsa040680.17707788
164Proteoglycans in cancer_Homo sapiens_hsa052050.17364629
165Small cell lung cancer_Homo sapiens_hsa052220.17082838
166Fructose and mannose metabolism_Homo sapiens_hsa000510.13895604
167Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10455560
168Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09986288

Most similar genes based on co-expression Upload to Enrichr

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