TLDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interferon-alpha (GO:0035457)6.23671830
2positive regulation of gamma-delta T cell activation (GO:0046645)6.17482499
3negative regulation of cell killing (GO:0031342)5.90084169
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.90084169
5type I interferon signaling pathway (GO:0060337)5.74497074
6cellular response to type I interferon (GO:0071357)5.74497074
7response to type I interferon (GO:0034340)5.73343321
8response to interferon-alpha (GO:0035455)5.44191925
9neutrophil activation involved in immune response (GO:0002283)5.22538049
10positive regulation of interferon-alpha production (GO:0032727)5.06392714
11cellular response to interferon-beta (GO:0035458)5.05360120
12negative regulation of viral genome replication (GO:0045071)4.81526680
13modulation by symbiont of host defense response (GO:0052031)4.80323273
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.80323273
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.80323273
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.80323273
17modulation by symbiont of host immune response (GO:0052553)4.80323273
18positive regulation by symbiont of host defense response (GO:0052509)4.80323273
19regulation of interferon-alpha production (GO:0032647)4.70818133
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.61888729
21hydrogen peroxide biosynthetic process (GO:0050665)4.59772173
22cellular response to exogenous dsRNA (GO:0071360)4.59321522
23regulation of B cell receptor signaling pathway (GO:0050855)4.54638389
24regulation of gamma-delta T cell activation (GO:0046643)4.54255065
25detection of other organism (GO:0098543)4.26784581
26regulation of interferon-beta biosynthetic process (GO:0045357)4.25396828
27angiotensin maturation (GO:0002003)4.23794463
28negative regulation of interleukin-12 production (GO:0032695)4.21020653
29granulocyte activation (GO:0036230)4.20260469
30production of molecular mediator involved in inflammatory response (GO:0002532)4.20002634
31positive regulation of monocyte chemotaxis (GO:0090026)4.17552414
32positive regulation of natural killer cell differentiation (GO:0032825)4.13911187
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.12659099
34regulation of gamma-delta T cell differentiation (GO:0045586)4.11656508
35response to interferon-beta (GO:0035456)4.08396447
36detection of bacterium (GO:0016045)4.05657155
37regulation of RIG-I signaling pathway (GO:0039535)4.05064972
38reactive oxygen species biosynthetic process (GO:1903409)4.02427225
39macrophage activation involved in immune response (GO:0002281)3.97545997
40negative thymic T cell selection (GO:0045060)3.96521535
41negative regulation of T cell mediated immunity (GO:0002710)3.94602144
42positive thymic T cell selection (GO:0045059)3.93541963
43negative T cell selection (GO:0043383)3.92708216
44positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.91471245
45respiratory burst (GO:0045730)3.89587004
46regulation of T-helper 1 cell differentiation (GO:0045625)3.86457151
47positive regulation of type 2 immune response (GO:0002830)3.78630435
48response to peptidoglycan (GO:0032494)3.78589201
49lipopolysaccharide-mediated signaling pathway (GO:0031663)3.77262275
50natural killer cell mediated immunity (GO:0002228)3.76351785
51natural killer cell mediated cytotoxicity (GO:0042267)3.76351785
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.74909109
53intestinal absorption (GO:0050892)3.71756504
54detection of external biotic stimulus (GO:0098581)3.69308023
55positive T cell selection (GO:0043368)3.68264889
56regulation of interferon-gamma biosynthetic process (GO:0045072)3.65959815
57detection of molecule of bacterial origin (GO:0032490)3.65619860
58cellular extravasation (GO:0045123)3.61748222
59neutrophil activation (GO:0042119)3.61676149
60interferon-gamma-mediated signaling pathway (GO:0060333)3.57987374
61regulation of T cell tolerance induction (GO:0002664)3.56380066
62eosinophil chemotaxis (GO:0048245)3.55509254
63positive regulation of chemokine biosynthetic process (GO:0045080)3.55231865
64leukocyte aggregation (GO:0070486)3.54726338
65regulation of tolerance induction (GO:0002643)3.45226519
66positive regulation of interferon-beta production (GO:0032728)3.45204904
67T cell selection (GO:0045058)3.43969000
68regulation of cholesterol esterification (GO:0010872)3.42598831
69regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.40809303
70response to interleukin-15 (GO:0070672)3.40537066
71myeloid cell activation involved in immune response (GO:0002275)3.39387847
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35930446
73regulation of monocyte chemotaxis (GO:0090025)3.35183855
74negative regulation of leukocyte mediated immunity (GO:0002704)3.33094513
75intestinal cholesterol absorption (GO:0030299)3.31974866
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.30664350
77phospholipid efflux (GO:0033700)3.29241215
78regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.28042076
79B cell receptor signaling pathway (GO:0050853)3.22872037
80cellular response to virus (GO:0098586)3.22628863
81detection of biotic stimulus (GO:0009595)3.22309815
82T cell migration (GO:0072678)3.21715006
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21043583
84response to host immune response (GO:0052572)3.21043583
85B cell mediated immunity (GO:0019724)3.19952402
86positive regulation of T cell cytokine production (GO:0002726)3.19932650
87thymic T cell selection (GO:0045061)3.17732242
88tolerance induction (GO:0002507)3.17569133
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.15202603
90striated muscle atrophy (GO:0014891)3.14810682
91positive regulation of interleukin-12 production (GO:0032735)3.14151497
92activated T cell proliferation (GO:0050798)3.13748581
93cellular response to zinc ion (GO:0071294)3.12479341
94response to muramyl dipeptide (GO:0032495)3.11965358
95eosinophil migration (GO:0072677)3.10618812
96regulation of alpha-beta T cell proliferation (GO:0046640)3.10413427
97superoxide anion generation (GO:0042554)3.07450494
98regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06996740
99positive regulation of tolerance induction (GO:0002645)3.06656143
100defense response to protozoan (GO:0042832)3.06588607
101defense response to virus (GO:0051607)3.06297607
102positive regulation of response to biotic stimulus (GO:0002833)3.06062208
103natural killer cell differentiation (GO:0001779)3.03374033
104T-helper 1 type immune response (GO:0042088)3.02813865
105regulation of B cell differentiation (GO:0045577)3.02571316
106antigen processing and presentation via MHC class Ib (GO:0002475)3.00083595
107neutrophil mediated immunity (GO:0002446)2.99363121
108positive regulation of B cell differentiation (GO:0045579)2.98852344
109regulation of regulatory T cell differentiation (GO:0045589)2.97408716
110negative regulation of viral process (GO:0048525)2.96832497
111cellular response to interleukin-15 (GO:0071350)2.95095398
112cellular response to interferon-gamma (GO:0071346)2.90874028
113positive regulation of lymphocyte migration (GO:2000403)2.89850411
114interferon-gamma secretion (GO:0072643)2.88724916
115regulation of necroptotic process (GO:0060544)2.87068870
116germinal center formation (GO:0002467)2.86124337
117positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85478174
118negative regulation of cytokine production involved in immune response (GO:0002719)2.84408018
119regulation of interleukin-12 biosynthetic process (GO:0045075)2.83270885
120leukocyte mediated cytotoxicity (GO:0001909)2.82777904
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82718916
122interferon-gamma production (GO:0032609)2.82219821
123regulation of chemokine biosynthetic process (GO:0045073)2.81594393
124hydrogen peroxide metabolic process (GO:0042743)2.81557376
125regulation of mononuclear cell migration (GO:0071675)2.81049554
126lymphocyte chemotaxis (GO:0048247)2.80460989
127regulation of viral genome replication (GO:0045069)2.80277051
128antigen processing and presentation of endogenous antigen (GO:0019883)2.80217701
129regulation of lymphocyte chemotaxis (GO:1901623)2.79794368
130regulation of mast cell degranulation (GO:0043304)2.79652316
131NIK/NF-kappaB signaling (GO:0038061)2.79464093
132positive regulation of granulocyte differentiation (GO:0030854)2.79384221
133negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.79043926
134dendritic cell migration (GO:0036336)2.78248214
135dendritic cell chemotaxis (GO:0002407)2.78085404
136positive regulation of mast cell activation (GO:0033005)2.78045847
137response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77255043
138response to host (GO:0075136)2.77255043
139response to host defenses (GO:0052200)2.77255043
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75650289
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75650289
142leukocyte degranulation (GO:0043299)2.75182272
143immunoglobulin mediated immune response (GO:0016064)2.73891868
144regulation of T cell mediated cytotoxicity (GO:0001914)2.73731118
145response to protozoan (GO:0001562)2.73698811
146negative regulation of erythrocyte differentiation (GO:0045647)2.73498630
147negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.73280940
148histone H3-K36 demethylation (GO:0070544)2.73037560
149myeloid leukocyte mediated immunity (GO:0002444)2.72522173
150regulation of T cell cytokine production (GO:0002724)2.72403681
151negative regulation of innate immune response (GO:0045824)2.72079469
152regulation of myeloid leukocyte mediated immunity (GO:0002886)2.71167629
153skeletal muscle adaptation (GO:0043501)2.67943438
154muscle atrophy (GO:0014889)2.66892768
155low-density lipoprotein particle remodeling (GO:0034374)2.66084255
156adhesion of symbiont to host cell (GO:0044650)2.64588582
157virion attachment to host cell (GO:0019062)2.64588582
158microglial cell activation (GO:0001774)2.63554167
159response to interferon-gamma (GO:0034341)2.62966103
160macrophage activation (GO:0042116)2.62098505
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.60945028
162regulation of natural killer cell differentiation (GO:0032823)2.60169221
163regulation of T cell chemotaxis (GO:0010819)2.60059929
164positive regulation of T cell chemotaxis (GO:0010820)2.60059929
165cellular response to vitamin D (GO:0071305)2.57407614
166regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55475451
167amyloid precursor protein catabolic process (GO:0042987)2.52509326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.36005707
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.85188342
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.78298881
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.15541639
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.10513759
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.47875020
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.41404442
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.00554033
9RUNX_20019798_ChIP-Seq_JUKART_Human2.95883729
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95643640
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66760818
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62938575
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50307111
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49985478
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36511877
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.32922043
17SCL_19346495_ChIP-Seq_HPC-7_Human2.22359857
18VDR_21846776_ChIP-Seq_THP-1_Human2.19772373
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.07782683
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.04951067
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98087042
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97593571
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91660358
24SOX2_20726797_ChIP-Seq_SW620_Human1.87905399
25GATA1_22025678_ChIP-Seq_K562_Human1.86255970
26UTX_26944678_Chip-Seq_JUKART_Human1.85745905
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.82129557
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78669776
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71071281
30MYC_22102868_ChIP-Seq_BL_Human1.69356513
31TCF7_22412390_ChIP-Seq_EML_Mouse1.67692814
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66163536
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54065847
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53776333
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49479565
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.46261188
37MAF_26560356_Chip-Seq_TH2_Human1.46027219
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45109647
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43494371
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41580259
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.39911256
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38215375
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37203965
44GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36211066
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36174964
46KDM2B_26808549_Chip-Seq_DND41_Human1.33917954
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32699476
48GATA4_25053715_ChIP-Seq_YYC3_Human1.32350074
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31676028
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29916420
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25939502
52EGR1_19032775_ChIP-ChIP_M12_Human1.22011603
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.20679469
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20070497
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15350843
56VDR_24787735_ChIP-Seq_THP-1_Human1.14008591
57SPI1_23127762_ChIP-Seq_K562_Human1.13825186
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13524053
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13236712
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13180402
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11818628
62PU_27001747_Chip-Seq_BMDM_Mouse1.08882314
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08876886
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08821440
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07999291
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.06293423
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05689407
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05121284
69VDR_24763502_ChIP-Seq_THP-1_Human1.03915451
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03309465
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03046854
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02692699
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02556226
74MYB_26560356_Chip-Seq_TH2_Human1.01261438
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01204214
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99782845
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99564914
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99132613
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98368969
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97871762
81SPI1_23547873_ChIP-Seq_NB4_Human0.97855408
82EGR1_19374776_ChIP-ChIP_THP-1_Human0.97721651
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96916822
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.96053811
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95809864
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94426698
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94265429
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93531410
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92635731
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92479191
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92479191
92MYB_26560356_Chip-Seq_TH1_Human0.92429498
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92336489
94GATA6_25053715_ChIP-Seq_YYC3_Human0.91840340
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.91493035
96GATA2_19941826_ChIP-Seq_K562_Human0.89691521
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89436486
98GATA3_26560356_Chip-Seq_TH2_Human0.89409134
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88851116
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88413941
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86931817
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86818469
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86381449
104MAF_26560356_Chip-Seq_TH1_Human0.86287455
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84198977
106ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83138535
107LXR_22292898_ChIP-Seq_THP-1_Human0.82806918
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81551482
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.81174417
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81090818
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80327984
112SMRT_27268052_Chip-Seq_Bcells_Human0.79477088
113GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78973055
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78238063
115BCL6_27268052_Chip-Seq_Bcells_Human0.77002642
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.76634637
117NCOR1_26117541_ChIP-Seq_K562_Human0.76084181
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.76037542
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75589255
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75179797
121GATA3_27048872_Chip-Seq_THYMUS_Human0.74036182
122CJUN_26792858_Chip-Seq_BT549_Human0.73173481
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73168254
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71794369
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71702118
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71108587
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70806134
128GATA1_19941826_ChIP-Seq_K562_Human0.70686310
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.69786131
130TP63_23658742_ChIP-Seq_EP156T_Human0.68496246
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.66389610
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66171953
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65759681
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65038684
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.64849126
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64380748
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64279967
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64065030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.58971327
2MP0002148_abnormal_hypersensitivity_rea3.70930756
3MP0009785_altered_susceptibility_to3.53478500
4MP0003724_increased_susceptibility_to3.30002748
5MP0003436_decreased_susceptibility_to3.29083295
6MP0001835_abnormal_antigen_presentation3.28113433
7MP0009840_abnormal_foam_cell2.97702880
8MP0006082_CNS_inflammation2.94172392
9MP0005025_abnormal_response_to2.75747270
10MP0003763_abnormal_thymus_physiology2.74399025
11MP0004510_myositis2.68905499
12MP0005000_abnormal_immune_tolerance2.68716571
13MP0003191_abnormal_cellular_cholesterol2.67001844
14MP0003303_peritoneal_inflammation2.66678351
15MP0002419_abnormal_innate_immunity2.48511974
16MP0005387_immune_system_phenotype2.40458070
17MP0001790_abnormal_immune_system2.40458070
18MP0000685_abnormal_immune_system2.37285944
19MP0005671_abnormal_response_to2.25959479
20MP0008260_abnormal_autophagy2.18906584
21MP0003183_abnormal_peptide_metabolism2.13076514
22MP0001853_heart_inflammation2.12184344
23MP0001533_abnormal_skeleton_physiology2.05420035
24MP0002452_abnormal_antigen_presenting2.04468231
25MP0002723_abnormal_immune_serum1.96517210
26MP0001666_abnormal_nutrient_absorption1.96292758
27MP0009764_decreased_sensitivity_to1.95681923
28MP0004947_skin_inflammation1.94071997
29MP0005058_abnormal_lysosome_morphology1.93048811
30MP0005464_abnormal_platelet_physiology1.85852734
31MP0001800_abnormal_humoral_immune1.83180509
32MP0010155_abnormal_intestine_physiology1.76784678
33MP0005310_abnormal_salivary_gland1.76115656
34MP0004043_abnormal_pH_regulation1.71963190
35MP0001819_abnormal_immune_cell1.71114108
36MP0002254_reproductive_system_inflammat1.69183724
37MP0002139_abnormal_hepatobiliary_system1.68512786
38MP0001845_abnormal_inflammatory_respons1.66786303
39MP0008469_abnormal_protein_level1.66499711
40MP0004782_abnormal_surfactant_physiolog1.61412673
41MP0002420_abnormal_adaptive_immunity1.61396273
42MP0002396_abnormal_hematopoietic_system1.58331407
43MP0003866_abnormal_defecation1.54660617
44MP0000689_abnormal_spleen_morphology1.53257437
45MP0003075_altered_response_to1.52982954
46MP0002722_abnormal_immune_system1.49437856
47MP0003828_pulmonary_edema1.44502053
48MP0005167_abnormal_blood-brain_barrier1.42707093
49MP0000465_gastrointestinal_hemorrhage1.41201809
50MP0003195_calcinosis1.41135947
51MP0000703_abnormal_thymus_morphology1.39625831
52MP0004019_abnormal_vitamin_homeostasis1.36291530
53MP0003448_altered_tumor_morphology1.32845300
54MP0004883_abnormal_blood_vessel1.29195223
55MP0002277_abnormal_respiratory_mucosa1.28464019
56MP0004381_abnormal_hair_follicle1.26114777
57MP0002405_respiratory_system_inflammati1.25250024
58MP0002006_tumorigenesis1.25086649
59MP0009643_abnormal_urine_homeostasis1.25068456
60MP0003705_abnormal_hypodermis_morpholog1.25000263
61MP0000604_amyloidosis1.21619862
62MP0003186_abnormal_redox_activity1.21423011
63MP0001851_eye_inflammation1.19738580
64MP0005166_decreased_susceptibility_to1.18701543
65MP0003172_abnormal_lysosome_physiology1.17479440
66MP0002136_abnormal_kidney_physiology1.16465439
67MP0002132_abnormal_respiratory_system1.15384283
68MP0001663_abnormal_digestive_system1.15326805
69MP0003252_abnormal_bile_duct1.14371211
70MP0005332_abnormal_amino_acid1.11166900
71MP0005085_abnormal_gallbladder_physiolo1.09596187
72MP0002998_abnormal_bone_remodeling1.07658052
73MP0002009_preneoplasia1.07572747
74MP0010329_abnormal_lipoprotein_level1.07165212
75MP0006054_spinal_hemorrhage1.06576610
76MP0000716_abnormal_immune_system1.06566634
77MP0003656_abnormal_erythrocyte_physiolo1.04827330
78MP0000858_altered_metastatic_potential1.03516052
79MP0003300_gastrointestinal_ulcer1.03471145
80MP0000569_abnormal_digit_pigmentation1.02403264
81MP0005164_abnormal_response_to1.02277334
82MP0009333_abnormal_splenocyte_physiolog1.00918266
83MP0010386_abnormal_urinary_bladder0.97709181
84MP0001765_abnormal_ion_homeostasis0.97468170
85MP0000490_abnormal_crypts_of0.97339006
86MP0004264_abnormal_extraembryonic_tissu0.97002431
87MP0008004_abnormal_stomach_pH0.96250691
88MP0000538_abnormal_urinary_bladder0.93613223
89MP0005319_abnormal_enzyme/_coenzyme0.92428351
90MP0001756_abnormal_urination0.92284143
91MP0010234_abnormal_vibrissa_follicle0.90080006
92MP0005636_abnormal_mineral_homeostasis0.89960917
93MP0005381_digestive/alimentary_phenotyp0.89622274
94MP0003690_abnormal_glial_cell0.88520710
95MP0000015_abnormal_ear_pigmentation0.88446239
96MP0005365_abnormal_bile_salt0.87690214
97MP0004858_abnormal_nervous_system0.86131915
98MP0002398_abnormal_bone_marrow0.85008997
99MP0005451_abnormal_body_composition0.82991459
100MP0003045_fibrosis0.82607126
101MP0003646_muscle_fatigue0.81039916
102MP0002138_abnormal_hepatobiliary_system0.80916930
103MP0002933_joint_inflammation0.79714357
104MP0000343_altered_response_to0.79487177
105MP0000249_abnormal_blood_vessel0.78964085
106MP0002429_abnormal_blood_cell0.78205752
107MP0009278_abnormal_bone_marrow0.78024631
108MP0003091_abnormal_cell_migration0.78021997
109MP0009763_increased_sensitivity_to0.77436227
110MP0005390_skeleton_phenotype0.77150539
111MP0003566_abnormal_cell_adhesion0.77147134
112MP0005075_abnormal_melanosome_morpholog0.75827119
113MP0004808_abnormal_hematopoietic_stem0.75537881
114MP0005448_abnormal_energy_balance0.74305183
115MP0005535_abnormal_body_temperature0.74031740
116MP0004147_increased_porphyrin_level0.72497222
117MP0003806_abnormal_nucleotide_metabolis0.71447847
118MP0009765_abnormal_xenobiotic_induced0.70085774
119MP0002693_abnormal_pancreas_physiology0.68724241
120MP0005076_abnormal_cell_differentiation0.68301015
121MP0009115_abnormal_fat_cell0.67988173
122MP0003453_abnormal_keratinocyte_physiol0.67908588
123MP0000609_abnormal_liver_physiology0.67268187
124MP0005584_abnormal_enzyme/coenzyme_acti0.66889826
125MP0002332_abnormal_exercise_endurance0.66610226
126MP0002166_altered_tumor_susceptibility0.66263955
127MP0005409_darkened_coat_color0.65268654
128MP0001545_abnormal_hematopoietic_system0.64360117
129MP0005397_hematopoietic_system_phenotyp0.64360117
130MP0001873_stomach_inflammation0.63788806

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)7.78540533
2Eczematoid dermatitis (HP:0000976)6.24019222
3Recurrent bacterial skin infections (HP:0005406)5.41041965
4Recurrent gram-negative bacterial infections (HP:0005420)5.33789471
5Recurrent abscess formation (HP:0002722)5.17591855
6Elevated erythrocyte sedimentation rate (HP:0003565)4.96903267
7Systemic lupus erythematosus (HP:0002725)4.73156705
8Abnormality of macrophages (HP:0004311)4.60871556
9T lymphocytopenia (HP:0005403)4.33854460
10Increased IgM level (HP:0003496)4.32042198
11Abnormality of T cell number (HP:0011839)4.13045233
12Gastrointestinal infarctions (HP:0005244)4.08070494
13Mediastinal lymphadenopathy (HP:0100721)4.01246202
14Gingivitis (HP:0000230)3.88858988
15Pigmentary retinal degeneration (HP:0001146)3.75077290
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.72612767
17Basal ganglia calcification (HP:0002135)3.72383731
18Axonal loss (HP:0003447)3.71288831
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.60651506
20Vacuolated lymphocytes (HP:0001922)3.60035298
21Poor head control (HP:0002421)3.54132528
22Autoimmune hemolytic anemia (HP:0001890)3.51169583
23Meningitis (HP:0001287)3.50365854
24Chronic mucocutaneous candidiasis (HP:0002728)3.38948348
25Recurrent cutaneous fungal infections (HP:0011370)3.38948348
26Micronodular cirrhosis (HP:0001413)3.33777059
27Encephalitis (HP:0002383)3.31655702
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.30460627
29Spontaneous hematomas (HP:0007420)3.26220105
30Keratoconjunctivitis sicca (HP:0001097)3.24161918
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.20145995
32Stomatitis (HP:0010280)3.17057931
33Petechiae (HP:0000967)3.14108303
34Abnormality of T cells (HP:0002843)3.12156327
35Increased cerebral lipofuscin (HP:0011813)3.07414759
36Abnormality of proline metabolism (HP:0010907)3.06578596
37Hydroxyprolinuria (HP:0003080)3.06578596
38Vasculitis (HP:0002633)3.05165043
39Chest pain (HP:0100749)3.04238434
40Recurrent fungal infections (HP:0002841)3.03689411
41Recurrent viral infections (HP:0004429)3.03258671
42Hemoptysis (HP:0002105)2.99777140
43Keratoconjunctivitis (HP:0001096)2.99033629
44Interstitial pulmonary disease (HP:0006530)2.97149465
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.92367461
46Progressive visual loss (HP:0000529)2.92217056
47Inflammation of the large intestine (HP:0002037)2.89233464
48Recurrent skin infections (HP:0001581)2.86333507
49Leukocytosis (HP:0001974)2.76648090
50Colitis (HP:0002583)2.76559015
51Gastrointestinal inflammation (HP:0004386)2.75752325
52Hemorrhage of the eye (HP:0011885)2.74538064
53Pustule (HP:0200039)2.73554365
54Orchitis (HP:0100796)2.72928026
55Hypergammaglobulinemia (HP:0010702)2.72306953
56Amyloidosis (HP:0011034)2.69102956
57Periodontitis (HP:0000704)2.68218173
58Prolonged bleeding time (HP:0003010)2.67485090
59Epistaxis (HP:0000421)2.63268351
60Slow saccadic eye movements (HP:0000514)2.61811847
61Arterial thrombosis (HP:0004420)2.60251515
62Thick nail (HP:0001805)2.55628495
63Abnormality of purine metabolism (HP:0004352)2.55618985
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53794975
65Increased IgE level (HP:0003212)2.52256414
66Peritonitis (HP:0002586)2.51471306
67Pulmonary embolism (HP:0002204)2.50903042
68Porencephaly (HP:0002132)2.49056413
69Panhypogammaglobulinemia (HP:0003139)2.48752630
70Optic neuritis (HP:0100653)2.47641144
71Retrobulbar optic neuritis (HP:0100654)2.47641144
72Recurrent bronchitis (HP:0002837)2.47492261
73Purpura (HP:0000979)2.45189129
74Chronic diarrhea (HP:0002028)2.44840843
75Tetraparesis (HP:0002273)2.44053909
76Nephritis (HP:0000123)2.43143576
77Abnormality of chloride homeostasis (HP:0011422)2.41960264
78Urticaria (HP:0001025)2.41116717
79Anorexia (HP:0002039)2.39720264
80Chronic obstructive pulmonary disease (HP:0006510)2.39062095
81Obstructive lung disease (HP:0006536)2.39062095
82Granulocytopenia (HP:0001913)2.38287954
83Myositis (HP:0100614)2.35346272
84Combined immunodeficiency (HP:0005387)2.34551134
85Abnormality of T cell physiology (HP:0011840)2.33877556
86Episodic fever (HP:0001954)2.29856137
87Gangrene (HP:0100758)2.28953378
88Abnormality of the pleura (HP:0002103)2.27986472
89Lymphopenia (HP:0001888)2.27904538
90Osteomyelitis (HP:0002754)2.27830540
91Lower limb hyperreflexia (HP:0002395)2.26188074
92Cellulitis (HP:0100658)2.24291273
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.20336177
94Hyperactive renin-angiotensin system (HP:0000841)2.19902601
95Prolonged neonatal jaundice (HP:0006579)2.19387243
96Abnormality of liposaccharide metabolism (HP:0010968)2.17836679
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.17836679
98Abnormality of glycolipid metabolism (HP:0010969)2.17836679
99Gingival bleeding (HP:0000225)2.17543484
100Metabolic alkalosis (HP:0200114)2.17315484
101Joint swelling (HP:0001386)2.16963575
102Ileus (HP:0002595)2.16879400
103Abnormality of the peritoneum (HP:0002585)2.14983299
104Hypochromic anemia (HP:0001931)2.13707350
105Dysostosis multiplex (HP:0000943)2.13545411
106Abnormality of the pericardium (HP:0001697)2.09139971
107Abnormality of the fingertips (HP:0001211)2.06880255
108IgM deficiency (HP:0002850)2.06435494
109Disinhibition (HP:0000734)2.06332637
110Esophageal neoplasm (HP:0100751)2.06242329
111Neoplasm of head and neck (HP:0012288)2.06242329
112Glomerulopathy (HP:0100820)2.05180863
113Subacute progressive viral hepatitis (HP:0006572)2.04423837
114Retinal atrophy (HP:0001105)2.01410990
115Pathologic fracture (HP:0002756)2.00288920
116Eosinophilia (HP:0001880)2.00168149
117Chronic otitis media (HP:0000389)1.96344899
118Hand muscle atrophy (HP:0009130)1.93914909
119Acute hepatic failure (HP:0006554)1.93084079
120Skin ulcer (HP:0200042)1.92670049
121Viral hepatitis (HP:0006562)1.90986592
122Abnormality of eosinophils (HP:0001879)1.90259132
123Recurrent pneumonia (HP:0006532)1.90140270
124Cleft eyelid (HP:0000625)1.89540357
125Mucopolysacchariduria (HP:0008155)1.89171871
126Urinary glycosaminoglycan excretion (HP:0003541)1.89171871
127Abnormality of the basal ganglia (HP:0002134)1.88573988
128Hepatosplenomegaly (HP:0001433)1.87897549
129Pulmonary infiltrates (HP:0002113)1.87343622
130Joint hemorrhage (HP:0005261)1.87228218
131Agammaglobulinemia (HP:0004432)1.86175154
132Hypochromic microcytic anemia (HP:0004840)1.86163643
133Nasal polyposis (HP:0100582)1.85798923
134Hematochezia (HP:0002573)1.84968917
135Acanthocytosis (HP:0001927)1.84779094
136Polyneuropathy (HP:0001271)1.83764525
137Premature loss of primary teeth (HP:0006323)1.83752423
138Thrombophlebitis (HP:0004418)1.83601782
139Skin rash (HP:0000988)1.83397875
140Cheilitis (HP:0100825)1.83116584
141Increased serum ferritin (HP:0003281)1.82996435
142Neoplasm of the tracheobronchial system (HP:0100552)1.82534263
143Glycosuria (HP:0003076)1.81939283
144Abnormality of urine glucose concentration (HP:0011016)1.81939283
145Cupped ribs (HP:0000887)1.78769303
146Abnormality of nucleobase metabolism (HP:0010932)1.76169919
147Spastic tetraparesis (HP:0001285)1.74899709
148Pancreatitis (HP:0001733)1.74394305
149Sepsis (HP:0100806)1.73569779
150Malnutrition (HP:0004395)1.73092033
151Loss of speech (HP:0002371)1.72117122
152Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69535458
153Abnormality of polysaccharide metabolism (HP:0011012)1.69535458
154Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69535458
155Nausea (HP:0002018)1.68500418
156Hyperglycinuria (HP:0003108)1.67661529
157Progressive microcephaly (HP:0000253)1.65496814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.80364671
2MAP3K143.79641441
3BLK3.61830677
4MST1R3.58720560
5SIK33.56901615
6TYK23.38108763
7PIM23.12075369
8RIPK43.03488986
9TBK12.65821013
10PRPF4B2.39532571
11SIK12.27356131
12BMX2.26093384
13MAP2K32.22998903
14SIK21.98335302
15MARK31.92087619
16IKBKE1.90531762
17WNK41.76709123
18JAK31.75983842
19JAK11.68697514
20ARAF1.66020452
21MAP3K121.65791212
22MST41.60852552
23ERN11.60704904
24FGR1.60133740
25ITK1.57682395
26MAP3K31.54437968
27MATK1.54299172
28TAOK11.49323043
29CSK1.48053252
30PRKG21.46168382
31FGFR41.43085089
32BMPR21.41793082
33CSF1R1.30026950
34ACVR1B1.29711100
35TESK11.29241643
36MAP3K131.27443836
37IRAK41.26687204
38TEC1.25518092
39EPHB11.24806527
40MAP4K11.24321464
41KIT1.23165465
42IKBKB1.21123946
43MAP3K21.20452591
44WNK31.14634939
45NLK1.14551597
46TNK21.14285843
47WNK11.12682764
48FRK1.12090982
49CDC42BPA1.09852314
50TAOK31.09180790
51RIPK11.07138540
52SYK1.06614964
53YES11.05950590
54GRK61.02615426
55MAP3K111.02354144
56ABL21.01966647
57PIM10.99421221
58STK40.97902300
59IRAK10.94870832
60NME20.93354393
61CHUK0.92281062
62LMTK20.92169808
63MARK20.86915236
64JAK20.85443288
65TAOK20.84099490
66PTK60.82984549
67FER0.82695965
68TGFBR20.82480848
69MAPK110.81981571
70CDK120.80945602
71MET0.80898589
72MAP3K100.80791180
73STK390.80410552
74PRKCD0.79220617
75TRPM70.77068240
76KSR20.73881616
77HCK0.72438967
78PIK3CG0.72306364
79ZAP700.71317471
80IRAK20.69891373
81MAPK70.67680850
82LYN0.67493119
83GRK70.65347021
84FGFR30.64909353
85ERBB30.64649954
86MAP3K70.63536358
87OXSR10.62196569
88FYN0.61929931
89IRAK30.61390815
90ERBB40.60020827
91EPHB20.56343934
92CAMKK20.53851756
93SGK30.53556060
94TRIB30.53351171
95CDK60.52925985
96MAPK120.52696776
97MAP3K60.51654114
98CDK40.50266923
99MAP3K10.49611542
100PRKCQ0.49487351
101DYRK1B0.49410227
102PTK2B0.48446391
103LCK0.48020575
104ABL10.46581614
105SGK20.46408082
106PRKCE0.45740674
107HIPK20.45334482
108MELK0.44745545
109STK100.44490229
110MAP2K20.43452496
111MUSK0.42549631
112TXK0.42471010
113PDPK10.41844801
114BRD40.41053489
115MAP3K50.40392691
116EGFR0.39662129
117EPHA30.39523837
118STK110.38766750
119PDGFRB0.38266609
120RET0.36834556
121TESK20.35625179
122MAP2K60.35422493
123PDK10.35406279
124BTK0.35232359
125BCR0.34811199
126STK240.34354937
127PTK20.32132321
128SRC0.30767206
129CAMKK10.30209828
130DAPK30.29789681
131MAPKAPK20.28946724
132LRRK20.28312087
133PRKACG0.27971224
134FES0.24634906
135ERBB20.23584981
136MAP3K90.23526290
137PRKAA10.22948602
138INSR0.22795902
139RPS6KA10.22558580
140STK380.22205461

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.50310762
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.65648216
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.53791245
4Mineral absorption_Homo sapiens_hsa049782.46038757
5Leishmaniasis_Homo sapiens_hsa051402.44078326
6Fat digestion and absorption_Homo sapiens_hsa049752.24453904
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.21865439
8Allograft rejection_Homo sapiens_hsa053302.18802735
9Pertussis_Homo sapiens_hsa051332.10552675
10Staphylococcus aureus infection_Homo sapiens_hsa051502.01070633
11Influenza A_Homo sapiens_hsa051641.99515407
12Graft-versus-host disease_Homo sapiens_hsa053321.96083913
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.84798657
14Renin-angiotensin system_Homo sapiens_hsa046141.83788790
15T cell receptor signaling pathway_Homo sapiens_hsa046601.80827327
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79968412
17Legionellosis_Homo sapiens_hsa051341.75680406
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.74389123
19Rheumatoid arthritis_Homo sapiens_hsa053231.74189291
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65877609
21Asthma_Homo sapiens_hsa053101.64954592
22Salmonella infection_Homo sapiens_hsa051321.64484708
23Vitamin digestion and absorption_Homo sapiens_hsa049771.60907429
24Folate biosynthesis_Homo sapiens_hsa007901.56893133
25Malaria_Homo sapiens_hsa051441.55220083
26Measles_Homo sapiens_hsa051621.51449365
27African trypanosomiasis_Homo sapiens_hsa051431.50506453
28TNF signaling pathway_Homo sapiens_hsa046681.45589358
29Osteoclast differentiation_Homo sapiens_hsa043801.41964797
30Tuberculosis_Homo sapiens_hsa051521.41468085
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33133475
32Type I diabetes mellitus_Homo sapiens_hsa049401.32062425
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30594298
34Sulfur metabolism_Homo sapiens_hsa009201.22378698
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.19948573
36Hepatitis C_Homo sapiens_hsa051601.19821380
37Lysosome_Homo sapiens_hsa041421.16714273
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14421840
39Other glycan degradation_Homo sapiens_hsa005111.14392891
40Toxoplasmosis_Homo sapiens_hsa051451.13779079
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10530307
42Galactose metabolism_Homo sapiens_hsa000521.07928388
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06381582
44Chemokine signaling pathway_Homo sapiens_hsa040621.05219536
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03744228
46Non-small cell lung cancer_Homo sapiens_hsa052231.01962500
47Herpes simplex infection_Homo sapiens_hsa051681.01357972
48Starch and sucrose metabolism_Homo sapiens_hsa005000.99902565
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98800817
50Autoimmune thyroid disease_Homo sapiens_hsa053200.97836600
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97374741
52Viral myocarditis_Homo sapiens_hsa054160.94681913
53Phagosome_Homo sapiens_hsa041450.94227632
54Caffeine metabolism_Homo sapiens_hsa002320.93643694
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.93562300
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.87846809
57Type II diabetes mellitus_Homo sapiens_hsa049300.85612215
58Bile secretion_Homo sapiens_hsa049760.82167309
59Apoptosis_Homo sapiens_hsa042100.81783238
60Protein digestion and absorption_Homo sapiens_hsa049740.79646645
61Shigellosis_Homo sapiens_hsa051310.79100755
62Arginine biosynthesis_Homo sapiens_hsa002200.78249791
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76010736
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74811444
65Pancreatic cancer_Homo sapiens_hsa052120.74175958
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74060416
67Fructose and mannose metabolism_Homo sapiens_hsa000510.74031087
68Hematopoietic cell lineage_Homo sapiens_hsa046400.73749873
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72222965
70Tryptophan metabolism_Homo sapiens_hsa003800.72129433
71Chronic myeloid leukemia_Homo sapiens_hsa052200.71701079
72Renal cell carcinoma_Homo sapiens_hsa052110.69097486
73Histidine metabolism_Homo sapiens_hsa003400.67949433
74Collecting duct acid secretion_Homo sapiens_hsa049660.67669922
75VEGF signaling pathway_Homo sapiens_hsa043700.67047394
76Epstein-Barr virus infection_Homo sapiens_hsa051690.65623537
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62989889
78B cell receptor signaling pathway_Homo sapiens_hsa046620.62683289
79FoxO signaling pathway_Homo sapiens_hsa040680.62584896
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.59999971
81Hepatitis B_Homo sapiens_hsa051610.57386281
82Amoebiasis_Homo sapiens_hsa051460.57214808
83Prion diseases_Homo sapiens_hsa050200.55593372
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.54112531
85Glycerolipid metabolism_Homo sapiens_hsa005610.53459373
86HTLV-I infection_Homo sapiens_hsa051660.52536156
87Endometrial cancer_Homo sapiens_hsa052130.52237522
88PPAR signaling pathway_Homo sapiens_hsa033200.51659281
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.50825967
90Antigen processing and presentation_Homo sapiens_hsa046120.50632860
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.50142258
92Primary immunodeficiency_Homo sapiens_hsa053400.49302251
93Inositol phosphate metabolism_Homo sapiens_hsa005620.47023630
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46854017
95Choline metabolism in cancer_Homo sapiens_hsa052310.46300801
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46134436
97Viral carcinogenesis_Homo sapiens_hsa052030.45844901
98Platelet activation_Homo sapiens_hsa046110.44961734
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.44090785
100GnRH signaling pathway_Homo sapiens_hsa049120.44088148
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.43694127
102HIF-1 signaling pathway_Homo sapiens_hsa040660.42961566
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42388973
104Endocytosis_Homo sapiens_hsa041440.39998685
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.39867624
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39756527
107Dorso-ventral axis formation_Homo sapiens_hsa043200.39662474
108Notch signaling pathway_Homo sapiens_hsa043300.39013992
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.38400821
110Insulin resistance_Homo sapiens_hsa049310.38359903
111mTOR signaling pathway_Homo sapiens_hsa041500.37748058
112Vibrio cholerae infection_Homo sapiens_hsa051100.37525678
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37307150
114Glutathione metabolism_Homo sapiens_hsa004800.36793148
115ABC transporters_Homo sapiens_hsa020100.34930556
116Prolactin signaling pathway_Homo sapiens_hsa049170.34841931
117Peroxisome_Homo sapiens_hsa041460.34300706
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33178526
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33049860
120Complement and coagulation cascades_Homo sapiens_hsa046100.30855474
121Acute myeloid leukemia_Homo sapiens_hsa052210.30728381
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29282619
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29115368
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28323326
125Arginine and proline metabolism_Homo sapiens_hsa003300.27955029
126Sphingolipid metabolism_Homo sapiens_hsa006000.27930743
127Colorectal cancer_Homo sapiens_hsa052100.27799218
128Ether lipid metabolism_Homo sapiens_hsa005650.27741310
129Prostate cancer_Homo sapiens_hsa052150.27562647
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27205265
131Pentose phosphate pathway_Homo sapiens_hsa000300.26755733
132Thyroid hormone synthesis_Homo sapiens_hsa049180.24764245
133Nitrogen metabolism_Homo sapiens_hsa009100.24379178

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