TLE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.27927010
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.25055007
3L-phenylalanine catabolic process (GO:0006559)5.25055007
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.93863292
5L-phenylalanine metabolic process (GO:0006558)4.93863292
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.12916580
7aromatic amino acid family catabolic process (GO:0009074)4.03319896
8regulation of timing of cell differentiation (GO:0048505)3.92365145
9negative regulation of fibrinolysis (GO:0051918)3.91201329
10high-density lipoprotein particle remodeling (GO:0034375)3.89569219
11bile acid biosynthetic process (GO:0006699)3.84219942
12alpha-linolenic acid metabolic process (GO:0036109)3.76369251
13regulation of development, heterochronic (GO:0040034)3.74986583
14planar cell polarity pathway involved in neural tube closure (GO:0090179)3.73918188
15sulfur amino acid catabolic process (GO:0000098)3.69002874
16regulation of fibrinolysis (GO:0051917)3.67869272
17reverse cholesterol transport (GO:0043691)3.66769026
18G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.59057993
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46740332
20cysteine metabolic process (GO:0006534)3.43925478
21regulation of protein activation cascade (GO:2000257)3.39146194
22pyrimidine nucleobase catabolic process (GO:0006208)3.37039961
23regulation of gene silencing by miRNA (GO:0060964)3.35552622
24regulation of gene silencing by RNA (GO:0060966)3.35552622
25regulation of posttranscriptional gene silencing (GO:0060147)3.35552622
26generation of neurons (GO:0048699)3.35062957
27bile acid metabolic process (GO:0008206)3.34693517
28glyoxylate metabolic process (GO:0046487)3.34278262
29cholesterol efflux (GO:0033344)3.33532087
30protein carboxylation (GO:0018214)3.30803404
31peptidyl-glutamic acid carboxylation (GO:0017187)3.30803404
32urea cycle (GO:0000050)3.29005573
33urea metabolic process (GO:0019627)3.29005573
34regulation of somitogenesis (GO:0014807)3.28414812
35protein-lipid complex remodeling (GO:0034368)3.27326983
36macromolecular complex remodeling (GO:0034367)3.27326983
37plasma lipoprotein particle remodeling (GO:0034369)3.27326983
38complement activation, alternative pathway (GO:0006957)3.24476490
39ganglion development (GO:0061548)3.19576232
40regulation of complement activation (GO:0030449)3.18158918
41midgut development (GO:0007494)3.16727892
42regulation of cholesterol esterification (GO:0010872)3.16370574
43heme transport (GO:0015886)3.11477657
44acylglycerol homeostasis (GO:0055090)3.09848401
45triglyceride homeostasis (GO:0070328)3.09848401
46neuronal stem cell maintenance (GO:0097150)3.09518509
47tyrosine metabolic process (GO:0006570)3.08589792
48convergent extension (GO:0060026)3.07591572
49kynurenine metabolic process (GO:0070189)3.06904469
50regulation of triglyceride catabolic process (GO:0010896)3.06196442
51axon ensheathment in central nervous system (GO:0032291)3.05172318
52central nervous system myelination (GO:0022010)3.05172318
53phospholipid efflux (GO:0033700)3.04430597
54regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.03208607
55positive regulation of neuroblast proliferation (GO:0002052)3.02804278
56tryptophan catabolic process (GO:0006569)3.01111156
57indole-containing compound catabolic process (GO:0042436)3.01111156
58indolalkylamine catabolic process (GO:0046218)3.01111156
59nitrogen cycle metabolic process (GO:0071941)3.00930323
60glutamate metabolic process (GO:0006536)2.99257535
61Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.98886679
62negative regulation of lipase activity (GO:0060192)2.98342503
63tryptophan metabolic process (GO:0006568)2.98281169
64cochlea morphogenesis (GO:0090103)2.97835165
65negative regulation of sterol transport (GO:0032372)2.95855246
66negative regulation of cholesterol transport (GO:0032375)2.95855246
67neuron fate commitment (GO:0048663)2.95450081
68L-serine metabolic process (GO:0006563)2.94597675
69spinal cord association neuron differentiation (GO:0021527)2.94111828
70dorsal/ventral axis specification (GO:0009950)2.93417333
71nucleobase catabolic process (GO:0046113)2.91868222
72cornea development in camera-type eye (GO:0061303)2.90738282
73specification of organ identity (GO:0010092)2.89686098
74cellular modified amino acid catabolic process (GO:0042219)2.87309828
75positive regulation of triglyceride lipase activity (GO:0061365)2.87091340
76positive regulation of lipoprotein lipase activity (GO:0051006)2.87091340
77negative regulation of protein activation cascade (GO:2000258)2.86198904
78regulation of establishment of planar polarity (GO:0090175)2.85605876
79fatty acid elongation (GO:0030497)2.85315276
80homocysteine metabolic process (GO:0050667)2.84603262
81positive regulation of fatty acid beta-oxidation (GO:0032000)2.83566764
82non-canonical Wnt signaling pathway (GO:0035567)2.83553500
83lung-associated mesenchyme development (GO:0060484)2.82948301
84plasma lipoprotein particle clearance (GO:0034381)2.82292638
85apical protein localization (GO:0045176)2.81340641
86metanephric mesenchyme development (GO:0072075)2.81132942
87aromatic amino acid family metabolic process (GO:0009072)2.78704478
88regulation of cell fate specification (GO:0042659)2.77357702
89coenzyme catabolic process (GO:0009109)2.77266485
90lateral sprouting from an epithelium (GO:0060601)2.77098049
91artery development (GO:0060840)2.76624181
92very long-chain fatty acid metabolic process (GO:0000038)2.76463370
93regulation of bile acid biosynthetic process (GO:0070857)2.75616375
94cell migration in hindbrain (GO:0021535)2.73705772
95ethanol oxidation (GO:0006069)2.73535717
96serine family amino acid catabolic process (GO:0009071)2.73337766
97notochord development (GO:0030903)2.70749436
98fibrinolysis (GO:0042730)2.70528525
99plasma lipoprotein particle assembly (GO:0034377)2.70214481
100cellular glucuronidation (GO:0052695)2.68603529
101kidney mesenchyme development (GO:0072074)2.67347414
102positive regulation of lipid catabolic process (GO:0050996)2.66888944
103proximal/distal pattern formation (GO:0009954)2.64756830
104outer ear morphogenesis (GO:0042473)2.64549990
105hindlimb morphogenesis (GO:0035137)2.64176406
106alpha-amino acid catabolic process (GO:1901606)2.63704468
107Notch signaling involved in heart development (GO:0061314)2.63360231
108negative regulation of catenin import into nucleus (GO:0035414)2.61825656
109lens fiber cell development (GO:0070307)2.59601818
110bile acid and bile salt transport (GO:0015721)2.59542344
111protein-lipid complex assembly (GO:0065005)2.59120284
112cholesterol homeostasis (GO:0042632)2.57480187
113asymmetric protein localization (GO:0008105)2.54855704
114response to nitrosative stress (GO:0051409)2.54814110
115cranial nerve morphogenesis (GO:0021602)2.54689311
116cellular ketone body metabolic process (GO:0046950)2.54207899
117sterol homeostasis (GO:0055092)2.54135877
118cellular amino acid catabolic process (GO:0009063)2.54095155
119segment specification (GO:0007379)2.52768903
120cellular response to cholesterol (GO:0071397)2.52047934
121intestinal cholesterol absorption (GO:0030299)2.50768404
122plasma lipoprotein particle organization (GO:0071827)2.49472977
123iron coordination entity transport (GO:1901678)2.49171528
124branching involved in salivary gland morphogenesis (GO:0060445)2.49084752
125uronic acid metabolic process (GO:0006063)2.48362090
126glucuronate metabolic process (GO:0019585)2.48362090
127fatty-acyl-CoA biosynthetic process (GO:0046949)2.48297196
128axonal fasciculation (GO:0007413)2.48059081
129cerebral cortex radially oriented cell migration (GO:0021799)2.47799844
130somite development (GO:0061053)2.47624873
131acetyl-CoA metabolic process (GO:0006084)2.47605779
132opsonization (GO:0008228)2.47167323
133low-density lipoprotein particle remodeling (GO:0034374)2.46608200
134neuron recognition (GO:0008038)2.46488574
135prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.45574923
136aorta morphogenesis (GO:0035909)2.45144442
137regulation of cholesterol biosynthetic process (GO:0045540)2.45008467
138limb bud formation (GO:0060174)2.44701671
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.44569586
140protein-lipid complex subunit organization (GO:0071825)2.44369347
141regulation of non-canonical Wnt signaling pathway (GO:2000050)2.44313255
142fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.43918924
143phospholipid homeostasis (GO:0055091)2.43650245
144long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.43072497
145gastrulation with mouth forming second (GO:0001702)2.42722591
146lipoprotein metabolic process (GO:0042157)2.42446730
147very-low-density lipoprotein particle assembly (GO:0034379)2.41216937
148negative regulation of complement activation (GO:0045916)2.40212501
149epoxygenase P450 pathway (GO:0019373)2.39556910
150regulation of cholesterol homeostasis (GO:2000188)2.37976678
151camera-type eye morphogenesis (GO:0048593)2.37284845
152neuron projection extension involved in neuron projection guidance (GO:1902284)2.36033024
153axon extension involved in axon guidance (GO:0048846)2.36033024
154cardiac right ventricle morphogenesis (GO:0003215)2.35275778
155embryonic camera-type eye morphogenesis (GO:0048596)2.35173089
156embryonic retina morphogenesis in camera-type eye (GO:0060059)2.33470284
157organ induction (GO:0001759)2.33196635
158otic vesicle formation (GO:0030916)2.32084179
159nephron tubule development (GO:0072080)2.31477834
160positive regulation of neural precursor cell proliferation (GO:2000179)2.30649622
161forebrain neuron differentiation (GO:0021879)2.30261455
162retinal ganglion cell axon guidance (GO:0031290)2.27863414
163developmental induction (GO:0031128)2.27700253
164hindbrain development (GO:0030902)2.26191253
165cell-cell signaling involved in cell fate commitment (GO:0045168)2.25670415
166embryonic foregut morphogenesis (GO:0048617)2.25528161
167renal system development (GO:0072001)2.25487999
168spinal cord development (GO:0021510)2.20569241
169nephron tubule formation (GO:0072079)2.19530457
170presynaptic membrane assembly (GO:0097105)2.18898242
171DNA damage response, detection of DNA damage (GO:0042769)2.18710860
172tongue development (GO:0043586)2.18315262
173ephrin receptor signaling pathway (GO:0048013)2.18090574
174mesenchymal to epithelial transition (GO:0060231)2.15650936
175appendage development (GO:0048736)2.15597313
176limb development (GO:0060173)2.15597313
177regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.14982999
178postsynaptic membrane organization (GO:0001941)2.14538988
179neurogenesis (GO:0022008)2.14088126
180suckling behavior (GO:0001967)2.13461606
181regulation of heart morphogenesis (GO:2000826)2.13173136
182embryonic hindlimb morphogenesis (GO:0035116)2.10933054
183mesenchyme morphogenesis (GO:0072132)2.09530313
184ventricular trabecula myocardium morphogenesis (GO:0003222)2.09186591
185digestive tract morphogenesis (GO:0048546)2.08981106
186myoblast migration (GO:0051451)2.08157351
187regulation of catenin import into nucleus (GO:0035412)2.07957605
188axon extension (GO:0048675)2.07883869
189positive regulation of chondrocyte differentiation (GO:0032332)2.07580965
190heart trabecula morphogenesis (GO:0061384)2.07565316
191regulation of cardioblast differentiation (GO:0051890)2.07124803
192heterochromatin organization (GO:0070828)2.05912149
193negative regulation of translation, ncRNA-mediated (GO:0040033)2.05271094
194regulation of translation, ncRNA-mediated (GO:0045974)2.05271094
195negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.05271094
196glandular epithelial cell differentiation (GO:0002067)2.05136069
197pituitary gland development (GO:0021983)2.04795349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.47488251
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.11877190
3* LXR_22158963_ChIP-Seq_LIVER_Mouse2.81992663
4EZH2_22144423_ChIP-Seq_EOC_Human2.61059050
5POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.52339804
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51234755
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51234755
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51234755
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46800392
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.44289025
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19583547
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16027960
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.11729932
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.11711489
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09138975
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09138975
17GBX2_23144817_ChIP-Seq_PC3_Human2.08054612
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06362113
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00688537
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95854222
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95282666
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93715367
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.92566585
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90333191
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90144003
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88750845
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85928242
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81724118
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80688472
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75047523
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.68957054
32* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64900764
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.63235237
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.60693641
35* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60564318
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59288847
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.56480736
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55111283
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54335742
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.54166804
41TAF15_26573619_Chip-Seq_HEK293_Human1.53299722
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.52966147
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49305203
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46776588
45CLOCK_20551151_ChIP-Seq_293T_Human1.45818681
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41110338
47* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40880376
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.39612748
49RNF2_27304074_Chip-Seq_NSC_Mouse1.37548493
50* CBX2_27304074_Chip-Seq_ESCs_Mouse1.36908517
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36587972
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36566733
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35087076
54* PIAS1_25552417_ChIP-Seq_VCAP_Human1.35065479
55* SOX2_16153702_ChIP-ChIP_HESCs_Human1.34990494
56* AHR_22903824_ChIP-Seq_MCF-7_Human1.34638185
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.34534495
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33563026
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32831779
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.31790249
61* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29077340
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27565540
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.26428760
64POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.25263682
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25173234
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23998773
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.23661224
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22713110
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.21701211
70* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20614907
71* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19954090
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19639106
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18866877
74* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18612176
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.18045194
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17163673
77* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16936583
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16545903
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16507418
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16295672
81DROSHA_22980978_ChIP-Seq_HELA_Human1.16129551
82* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15885535
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14714649
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14551271
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14412498
86AR_21572438_ChIP-Seq_LNCaP_Human1.12633777
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.12480655
88* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11980978
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11455119
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11081859
91* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10481404
92* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10467988
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09897672
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09798255
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09631476
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09211450
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09086445
98ZNF274_21170338_ChIP-Seq_K562_Hela1.09030759
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08352399
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08352399
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.08098047
102* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07108965
103* SMAD3_21741376_ChIP-Seq_EPCs_Human1.06924593
104* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06830976
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06491535
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06368099
107RARB_27405468_Chip-Seq_BRAIN_Mouse1.06309725
108* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06166110
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05662119
110* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04647170
111* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03804057
112* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03627987
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02256311
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00637412
115* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00360196
116KDM2B_26808549_Chip-Seq_K562_Human0.99137394
117BCAT_22108803_ChIP-Seq_LS180_Human0.98219478
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.97517258
119* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97270243
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96798983
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96180274
122FOXM1_23109430_ChIP-Seq_U2OS_Human0.96138455
123SMAD4_21799915_ChIP-Seq_A2780_Human0.95974785
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95810796
125* TP53_18474530_ChIP-ChIP_U2OS_Human0.94951102
126* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94487983
127AR_21909140_ChIP-Seq_LNCAP_Human0.94252185
128* ESR1_20079471_ChIP-ChIP_T-47D_Human0.92727816
129* SOX2_21211035_ChIP-Seq_LN229_Gbm0.92618085
130REST_21632747_ChIP-Seq_MESCs_Mouse0.92090556
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.92068445
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.90542389
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89974491
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89509846
135* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89181441
136GATA1_26923725_Chip-Seq_HPCs_Mouse0.87528416
137* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87476034
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86865897
139* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86575702
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86131717
141SOX3_22085726_ChIP-Seq_NPCs_Mouse0.86109425
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85361770
143MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84168119
144* AR_19668381_ChIP-Seq_PC3_Human0.84103603
145PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83048318
146* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81407769
147STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.81011967
148* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78529510
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77756550
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77444141
151KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77385073
152KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77379509
153OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76157227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.28887387
2MP0005360_urolithiasis4.64008970
3MP0006292_abnormal_olfactory_placode4.12937924
4MP0005085_abnormal_gallbladder_physiolo3.91431876
5MP0005365_abnormal_bile_salt3.72781181
6MP0008875_abnormal_xenobiotic_pharmacok2.97289803
7MP0003252_abnormal_bile_duct2.63586833
8MP0002938_white_spotting2.62863462
9MP0005257_abnormal_intraocular_pressure2.52828839
10MP0010329_abnormal_lipoprotein_level2.36053336
11MP0004133_heterotaxia2.11682894
12MP0004270_analgesia2.08575604
13MP0005171_absent_coat_pigmentation2.06370598
14MP0000537_abnormal_urethra_morphology1.95448264
15MP0000778_abnormal_nervous_system1.87518212
16MP0005083_abnormal_biliary_tract1.80952197
17MP0009053_abnormal_anal_canal1.77691421
18MP0003705_abnormal_hypodermis_morpholog1.74567177
19MP0003806_abnormal_nucleotide_metabolis1.68587814
20MP0002697_abnormal_eye_size1.65492152
21MP0001666_abnormal_nutrient_absorption1.64728764
22MP0004859_abnormal_synaptic_plasticity1.63570524
23MP0002638_abnormal_pupillary_reflex1.63556128
24MP0001293_anophthalmia1.60947997
25MP0010030_abnormal_orbit_morphology1.58277238
26MP0003122_maternal_imprinting1.58228402
27MP0005248_abnormal_Harderian_gland1.57769262
28MP0004885_abnormal_endolymph1.57139498
29MP0005332_abnormal_amino_acid1.54774009
30MP0003136_yellow_coat_color1.53136263
31MP0003880_abnormal_central_pattern1.50798013
32MP0004272_abnormal_basement_membrane1.49741233
33MP0000428_abnormal_craniofacial_morphol1.49527969
34MP0003941_abnormal_skin_development1.47724999
35MP0000462_abnormal_digestive_system1.43834096
36MP0003868_abnormal_feces_composition1.41537531
37MP0008789_abnormal_olfactory_epithelium1.40347591
38MP0004858_abnormal_nervous_system1.39929169
39MP0000733_abnormal_muscle_development1.38589019
40MP0001286_abnormal_eye_development1.36779655
41MP0003121_genomic_imprinting1.35406353
42MP0002249_abnormal_larynx_morphology1.32386475
43MP0000534_abnormal_ureter_morphology1.31712847
44MP0003787_abnormal_imprinting1.29786026
45MP0003329_amyloid_beta_deposits1.27446137
46MP0002118_abnormal_lipid_homeostasis1.26247858
47MP0009840_abnormal_foam_cell1.24107183
48MP0002116_abnormal_craniofacial_bone1.24085442
49MP0003890_abnormal_embryonic-extraembry1.18111532
50MP0003690_abnormal_glial_cell1.17524223
51MP0005187_abnormal_penis_morphology1.17404154
52MP0002233_abnormal_nose_morphology1.15760085
53MP0008438_abnormal_cutaneous_collagen1.14894115
54MP0003123_paternal_imprinting1.14388564
55MP0009379_abnormal_foot_pigmentation1.12927365
56MP0002111_abnormal_tail_morphology1.12509693
57MP0003567_abnormal_fetal_cardiomyocyte1.12205727
58MP0006072_abnormal_retinal_apoptosis1.10603371
59MP0005197_abnormal_uvea_morphology1.10244796
60MP0005394_taste/olfaction_phenotype1.07952045
61MP0005499_abnormal_olfactory_system1.07952045
62MP0000026_abnormal_inner_ear1.07217254
63MP0003385_abnormal_body_wall1.05958755
64MP0005623_abnormal_meninges_morphology1.05629301
65MP0009672_abnormal_birth_weight1.05131111
66MP0010234_abnormal_vibrissa_follicle1.05082132
67MP0003635_abnormal_synaptic_transmissio1.04492262
68MP0003755_abnormal_palate_morphology1.04085477
69MP0000955_abnormal_spinal_cord1.03093313
70MP0009780_abnormal_chondrocyte_physiolo1.02931683
71MP0002653_abnormal_ependyma_morphology1.01250382
72MP0002254_reproductive_system_inflammat1.00781918
73MP0005391_vision/eye_phenotype1.00429900
74MP0000631_abnormal_neuroendocrine_gland0.99780884
75MP0002751_abnormal_autonomic_nervous0.98869658
76MP0000566_synostosis0.98793136
77MP0000049_abnormal_middle_ear0.98471235
78MP0000920_abnormal_myelination0.98192123
79MP0009703_decreased_birth_body0.97476801
80MP0003937_abnormal_limbs/digits/tail_de0.97431895
81MP0002085_abnormal_embryonic_tissue0.97365350
82MP0002063_abnormal_learning/memory/cond0.96892888
83MP0003942_abnormal_urinary_system0.96646605
84MP0010368_abnormal_lymphatic_system0.95855915
85MP0001486_abnormal_startle_reflex0.94886089
86MP0000432_abnormal_head_morphology0.94310482
87MP0009384_cardiac_valve_regurgitation0.93721220
88MP0002084_abnormal_developmental_patter0.92589015
89MP0004019_abnormal_vitamin_homeostasis0.92211026
90MP0002184_abnormal_innervation0.91735383
91MP0000579_abnormal_nail_morphology0.91661138
92MP0009250_abnormal_appendicular_skeleto0.91368599
93MP0000604_amyloidosis0.91365030
94MP0000762_abnormal_tongue_morphology0.91150535
95MP0001529_abnormal_vocalization0.90194302
96MP0008932_abnormal_embryonic_tissue0.89972412
97MP0001346_abnormal_lacrimal_gland0.88905962
98MP0000516_abnormal_urinary_system0.87794628
99MP0005367_renal/urinary_system_phenotyp0.87794628
100MP0002734_abnormal_mechanical_nocicepti0.87344569
101MP0003195_calcinosis0.86776169
102MP0002282_abnormal_trachea_morphology0.86632151
103MP0000609_abnormal_liver_physiology0.86570569
104MP0002295_abnormal_pulmonary_circulatio0.85944769
105MP0003119_abnormal_digestive_system0.84933236
106MP0000427_abnormal_hair_cycle0.84679999
107MP0001485_abnormal_pinna_reflex0.84407218
108MP0006276_abnormal_autonomic_nervous0.84371953
109MP0002081_perinatal_lethality0.84173437
110MP0001177_atelectasis0.82766829
111MP0002752_abnormal_somatic_nervous0.82412239
112MP0001340_abnormal_eyelid_morphology0.81956920
113MP0002108_abnormal_muscle_morphology0.81783729
114MP0003938_abnormal_ear_development0.80293994
115MP0003861_abnormal_nervous_system0.79848107
116MP0003632_abnormal_nervous_system0.79215081
117MP0002733_abnormal_thermal_nociception0.78943431
118MP0002882_abnormal_neuron_morphology0.77885885
119MP0008877_abnormal_DNA_methylation0.77397322
120MP0004197_abnormal_fetal_growth/weight/0.77356606
121MP0002114_abnormal_axial_skeleton0.76615525
122MP0009745_abnormal_behavioral_response0.75517918
123MP0010678_abnormal_skin_adnexa0.75206899
124MP0002932_abnormal_joint_morphology0.74732575
125MP0002272_abnormal_nervous_system0.74729583
126MP0005647_abnormal_sex_gland0.74380536
127MP0001968_abnormal_touch/_nociception0.74257951
128MP0001299_abnormal_eye_distance/0.73683443
129MP0002234_abnormal_pharynx_morphology0.73194833
130MP0003115_abnormal_respiratory_system0.72858687
131MP0003935_abnormal_craniofacial_develop0.72836822
132MP0003634_abnormal_glial_cell0.72471480
133MP0005195_abnormal_posterior_eye0.71770869
134MP0002152_abnormal_brain_morphology0.71188930
135MP0000751_myopathy0.70800701
136MP0000647_abnormal_sebaceous_gland0.70496907
137MP0005508_abnormal_skeleton_morphology0.69091395
138MP0001849_ear_inflammation0.68993409
139MP0005377_hearing/vestibular/ear_phenot0.68723071
140MP0003878_abnormal_ear_physiology0.68723071
141MP0002092_abnormal_eye_morphology0.68406660
142MP0002736_abnormal_nociception_after0.68173231
143MP0003283_abnormal_digestive_organ0.68042562
144MP0002557_abnormal_social/conspecific_i0.67764377
145MP0002572_abnormal_emotion/affect_behav0.65987336
146MP0000613_abnormal_salivary_gland0.65620123
147MP0005503_abnormal_tendon_morphology0.65358237
148MP0002064_seizures0.64750126
149MP0001270_distended_abdomen0.63399861
150MP0002177_abnormal_outer_ear0.63121065
151MP0002109_abnormal_limb_morphology0.63090718

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.31194748
2Intrahepatic cholestasis (HP:0001406)5.06824270
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.64458363
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.00314927
5Xanthomatosis (HP:0000991)3.86637621
6Hypobetalipoproteinemia (HP:0003563)3.77919098
7Prolonged partial thromboplastin time (HP:0003645)3.45511231
8Complement deficiency (HP:0004431)3.24973107
9Hyperlipoproteinemia (HP:0010980)3.14819412
10Hypolipoproteinemia (HP:0010981)3.01565029
11Cutaneous syndactyly (HP:0012725)3.00320772
12Rib fusion (HP:0000902)2.96053086
13Neurofibrillary tangles (HP:0002185)2.94693466
14Epidermoid cyst (HP:0200040)2.93927028
15Cerebral inclusion bodies (HP:0100314)2.86543916
16Conjugated hyperbilirubinemia (HP:0002908)2.85324305
17Hypoalphalipoproteinemia (HP:0003233)2.84936081
18Hemivertebrae (HP:0002937)2.81893482
19Fat malabsorption (HP:0002630)2.69046469
20Turricephaly (HP:0000262)2.68744355
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.67386708
22Coronal craniosynostosis (HP:0004440)2.63594253
23Abnormality of sulfur amino acid metabolism (HP:0004339)2.57424106
24Degeneration of the lateral corticospinal tracts (HP:0002314)2.56805012
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.56805012
26Abnormality of the corticospinal tract (HP:0002492)2.54495226
27Abnormality of the labia minora (HP:0012880)2.49236671
28Calcaneovalgus deformity (HP:0001848)2.48685079
29Abnormality of methionine metabolism (HP:0010901)2.45979922
30Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42925072
31Hyperglycinemia (HP:0002154)2.39189653
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37193181
33Partial duplication of thumb phalanx (HP:0009944)2.37186938
34Vertebral arch anomaly (HP:0008438)2.32946020
35Deformed tarsal bones (HP:0008119)2.32821559
36Hypochromic microcytic anemia (HP:0004840)2.30673056
37Ketosis (HP:0001946)2.30524387
38Preaxial foot polydactyly (HP:0001841)2.29923273
39Buphthalmos (HP:0000557)2.27308031
40Abnormality of the common coagulation pathway (HP:0010990)2.26974057
41Septo-optic dysplasia (HP:0100842)2.24347654
42Hyperventilation (HP:0002883)2.22703889
43Bifid scrotum (HP:0000048)2.21686110
44Hepatoblastoma (HP:0002884)2.21670400
45Renal dysplasia (HP:0000110)2.21489805
46Vitreoretinal degeneration (HP:0000655)2.21481765
47Optic nerve hypoplasia (HP:0000609)2.20091009
48Trigonocephaly (HP:0000243)2.19345379
49Broad thumb (HP:0011304)2.17715521
50Hyperammonemia (HP:0001987)2.16511125
51Renal hypoplasia (HP:0000089)2.12461053
52Megalencephaly (HP:0001355)2.12058868
53Bronchomalacia (HP:0002780)2.11498920
54Partial duplication of the phalanx of hand (HP:0009999)2.09857816
55Synostosis of carpal bones (HP:0005048)2.09576788
56Abnormality of the middle phalanges of the toes (HP:0010183)2.09366387
57Abnormality of the intrinsic pathway (HP:0010989)2.08791362
58Tracheomalacia (HP:0002779)2.07877818
59Insidious onset (HP:0003587)2.07058014
60Termporal pattern (HP:0011008)2.07058014
61Abnormality of complement system (HP:0005339)2.06020962
62Abnormality of glycine metabolism (HP:0010895)2.05673536
63Abnormality of serine family amino acid metabolism (HP:0010894)2.05673536
64Abnormality of the phalanges of the hallux (HP:0010057)2.05335342
65White forelock (HP:0002211)2.03361424
66Amblyopia (HP:0000646)2.02538966
67Facial hemangioma (HP:0000329)1.99615531
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98598339
69Hypercholesterolemia (HP:0003124)1.97088600
70Choanal stenosis (HP:0000452)1.95370997
71Aplasia/Hypoplasia of the sternum (HP:0006714)1.95225538
72High anterior hairline (HP:0009890)1.94979572
73Malnutrition (HP:0004395)1.94628755
74Thickened helices (HP:0000391)1.94292873
75Spontaneous abortion (HP:0005268)1.91833451
76Oligodactyly (HP:0012165)1.89738375
77Back pain (HP:0003418)1.87287429
78Hyperglycinuria (HP:0003108)1.86895045
79Shawl scrotum (HP:0000049)1.86745225
80Joint hemorrhage (HP:0005261)1.85788197
81Abnormality of the Achilles tendon (HP:0005109)1.85632782
82Broad finger (HP:0001500)1.85622868
83Pseudobulbar signs (HP:0002200)1.85318325
84Broad phalanges of the hand (HP:0009768)1.85237870
85Infantile muscular hypotonia (HP:0008947)1.85081668
86Broad hallux (HP:0010055)1.84895343
87Cortical dysplasia (HP:0002539)1.83090120
88Skin nodule (HP:0200036)1.82236183
89Abnormality of the antihelix (HP:0009738)1.82205969
90Pterygium (HP:0001059)1.82109742
91Shallow orbits (HP:0000586)1.81887983
92Hemorrhage of the eye (HP:0011885)1.80474796
93Microglossia (HP:0000171)1.80027673
94Patchy hypopigmentation of hair (HP:0011365)1.79372115
95Abnormality of the calcaneus (HP:0008364)1.79098510
96Difficulty running (HP:0009046)1.77578750
97Myokymia (HP:0002411)1.76491212
98Broad metatarsal (HP:0001783)1.75387975
99Hypophosphatemic rickets (HP:0004912)1.75315921
100Morphological abnormality of the inner ear (HP:0011390)1.74894365
101Neonatal short-limb short stature (HP:0008921)1.74457210
102Broad toe (HP:0001837)1.73716676
103Wide anterior fontanel (HP:0000260)1.73399459
104Delayed CNS myelination (HP:0002188)1.73287528
105Anophthalmia (HP:0000528)1.72567224
106Congenital glaucoma (HP:0001087)1.72562615
107Periauricular skin pits (HP:0100277)1.72173055
108Preauricular pit (HP:0004467)1.72173055
109Supranuclear gaze palsy (HP:0000605)1.72146398
110Alacrima (HP:0000522)1.72063238
111Amyloidosis (HP:0011034)1.71534320
112Anosmia (HP:0000458)1.71085095
113Spastic gait (HP:0002064)1.71046068
114Steatorrhea (HP:0002570)1.70795472
115Broad phalanx (HP:0006009)1.70685530
116Sprengel anomaly (HP:0000912)1.70284761
117Meningocele (HP:0002435)1.69706309
118Abnormality of cochlea (HP:0000375)1.68600907
119Carpal synostosis (HP:0009702)1.67947088
120Gastrointestinal atresia (HP:0002589)1.67853173
121Supernumerary ribs (HP:0005815)1.67136855
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.66975014
123Tented upper lip vermilion (HP:0010804)1.66947565
124Morphological abnormality of the pyramidal tract (HP:0002062)1.65749243
125Colon cancer (HP:0003003)1.65571850
126Coarctation of aorta (HP:0001680)1.65321458
127Chin dimple (HP:0010751)1.63335651
128Hypoplasia of the iris (HP:0007676)1.62889915
129Spastic diplegia (HP:0001264)1.62870323
130Broad distal phalanx of finger (HP:0009836)1.62054843
131Shoulder girdle muscle weakness (HP:0003547)1.61850400
132Aplasia involving bones of the upper limbs (HP:0009823)1.61363214
133Aplasia of the phalanges of the hand (HP:0009802)1.61363214
134Aplasia involving bones of the extremities (HP:0009825)1.61363214
135Ankyloglossia (HP:0010296)1.61229793
136Broad long bones (HP:0005622)1.61035638
137Abnormality of the diencephalon (HP:0010662)1.60554558
138Myelomeningocele (HP:0002475)1.60232455
139Abnormality of the aortic arch (HP:0012303)1.60207855
140Intention tremor (HP:0002080)1.59898643
141Absent eyebrow (HP:0002223)1.58523770
142Scapular winging (HP:0003691)1.58165612
143Maternal diabetes (HP:0009800)1.57072333
144Cutaneous finger syndactyly (HP:0010554)1.56642529
145Midline defect of the nose (HP:0004122)1.56445827
146Drooling (HP:0002307)1.56325047
147Excessive salivation (HP:0003781)1.56325047
148Abnormality of the 4th metacarpal (HP:0010012)1.55862546
149Exotropia (HP:0000577)1.55735435
150Short 4th metacarpal (HP:0010044)1.55503654
151Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55503654
152Lymphangioma (HP:0100764)1.55335197
153Enlarged kidneys (HP:0000105)1.54757048
154Synostosis involving the elbow (HP:0003938)1.54583035
155Humeroradial synostosis (HP:0003041)1.54583035
156Hepatocellular carcinoma (HP:0001402)1.54225768
157Mitral valve prolapse (HP:0001634)1.54151468
158Sensory axonal neuropathy (HP:0003390)1.53878101
159Duplication of thumb phalanx (HP:0009942)1.53251322
160Abnormality of the shoulder girdle musculature (HP:0001435)1.51696972
161Hypoglycemic coma (HP:0001325)1.51055464
162Esophageal atresia (HP:0002032)1.50606943
163Status epilepticus (HP:0002133)1.50591459
164Heterochromia iridis (HP:0001100)1.50243369
165Arnold-Chiari malformation (HP:0002308)1.49918217
166Hammertoe (HP:0001765)1.49423368
167Abnormality of the lower motor neuron (HP:0002366)1.49397294
168Abnormality of the intervertebral disk (HP:0005108)1.49100078
169Vascular calcification (HP:0004934)1.49077262
170Papillary thyroid carcinoma (HP:0002895)1.48786350
171Preauricular skin tag (HP:0000384)1.48357681
172Hydroureter (HP:0000072)1.47802708
173Rhabdomyosarcoma (HP:0002859)1.47771781
174Absent septum pellucidum (HP:0001331)1.47762947
175Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.46083876
176Congenital malformation of the right heart (HP:0011723)1.46040909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.14785143
2LATS12.74527911
3STK38L2.59163069
4STK392.40933751
5MAP3K22.30049105
6FGFR22.19841987
7ICK2.09748818
8EPHB22.03583273
9NTRK31.85647708
10DDR21.84881085
11SRPK11.84012776
12KSR21.77714245
13MAP3K41.76578349
14MET1.76451409
15VRK21.73905457
16NTRK11.72722351
17MARK11.69533525
18CASK1.67659147
19DAPK21.65406853
20DYRK31.64498008
21MAP2K41.64038365
22SIK11.60055902
23CDK191.56988372
24TAF11.55414649
25AKT31.49899624
26KSR11.49394725
27PAK61.47933601
28INSRR1.45543459
29FRK1.44394770
30BCR1.38533675
31EPHA21.38412030
32FGR1.36159608
33LATS21.35729700
34PDGFRA1.34802133
35BCKDK1.34253940
36WEE11.31796367
37TYRO31.31029558
38WNK31.29147647
39FER1.28585603
40ERBB41.25405772
41MAP3K101.24553361
42CSNK1A1L1.22081519
43PNCK1.22041517
44SGK2231.19216294
45SGK4941.19216294
46MAP3K61.17490132
47MKNK21.15192398
48MKNK11.14550259
49OXSR11.13675859
50PHKG11.13293698
51PHKG21.13293698
52RET1.10917074
53BRSK21.09025606
54MAP4K21.08089365
55DYRK21.07776853
56PAK31.06037491
57EPHB11.05298260
58CAMK1G1.04461482
59MAP3K91.03891501
60LMTK21.03877092
61CSNK1G21.01384735
62OBSCN0.99249697
63NTRK20.98464212
64PTK60.94559595
65CAMK2B0.92992663
66UHMK10.92320985
67MAPK130.92248032
68ERBB20.91293633
69CSNK1G10.90348294
70PTK20.89057646
71CSNK1G30.89021387
72BRSK10.87980961
73ERN10.86158066
74PKN10.85347324
75TTK0.85313214
76MAP2K20.85055855
77EPHA30.83837887
78EEF2K0.83716385
79CDK80.83485620
80GRK10.82805888
81PRKD30.82005807
82TRIB30.81308084
83TTN0.79432767
84CDK50.79127916
85CDC70.79050621
86MINK10.76624900
87NUAK10.75515434
88TESK20.74630988
89MAP2K10.74174971
90CDK70.73774001
91MAPK150.71535312
92ERBB30.70222223
93PRKCZ0.70008750
94BMX0.67842771
95PLK10.66257017
96HIPK20.66040151
97CAMK2G0.64758683
98CAMK2A0.64169759
99RIPK10.62574098
100PTK2B0.62222932
101MELK0.61965686
102PDGFRB0.61345393
103FGFR40.61302424
104MAP2K70.61050072
105CDK30.60786802
106SMG10.60766936
107DYRK1A0.60276167
108MOS0.59058991
109NEK60.59047192
110PRPF4B0.58668413
111CHEK20.57178786
112BRAF0.55791694
113MTOR0.53504058
114PAK20.53176388
115DYRK1B0.53171843
116AKT20.53111251
117SGK30.52261796
118ROCK20.51879481
119MARK20.51764761
120TNIK0.51753393
121GSK3A0.51495065
122BMPR1B0.51064838
123PINK10.50716254
124WNK40.50447946
125CDK11A0.50273417
126CDK120.50072608
127STK110.49067198
128AURKA0.47365668
129CDK150.45485216
130CSNK1E0.45199362
131CDK90.44724438
132ROCK10.43834269
133CAMK2D0.43799377
134STK240.43611303
135NME10.43606899
136MAP3K70.43467897
137CAMK1D0.43357335
138SGK20.43321293
139CHEK10.43124754
140CDK180.42157881
141PRKCG0.42103269
142FGFR10.42039345
143PIK3CA0.40924903

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.95799178
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.67762139
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61493532
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49773363
5Arginine biosynthesis_Homo sapiens_hsa002202.49702934
6Complement and coagulation cascades_Homo sapiens_hsa046102.14525282
7Butanoate metabolism_Homo sapiens_hsa006501.91559657
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91545329
9Tryptophan metabolism_Homo sapiens_hsa003801.89526442
10Fatty acid degradation_Homo sapiens_hsa000711.89113995
11Notch signaling pathway_Homo sapiens_hsa043301.88990063
12Sulfur metabolism_Homo sapiens_hsa009201.88219686
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79231953
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76830862
15Steroid biosynthesis_Homo sapiens_hsa001001.74415863
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73490479
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71514275
18PPAR signaling pathway_Homo sapiens_hsa033201.69167425
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69099717
20Bile secretion_Homo sapiens_hsa049761.68230515
21Fatty acid metabolism_Homo sapiens_hsa012121.58876015
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57762196
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56915996
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.53356667
25Histidine metabolism_Homo sapiens_hsa003401.48206204
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44534906
27Chemical carcinogenesis_Homo sapiens_hsa052041.44507694
28Fatty acid elongation_Homo sapiens_hsa000621.40290464
29Propanoate metabolism_Homo sapiens_hsa006401.33558357
30Peroxisome_Homo sapiens_hsa041461.31786766
31Sulfur relay system_Homo sapiens_hsa041221.30679479
32Fat digestion and absorption_Homo sapiens_hsa049751.28817510
33Ribosome_Homo sapiens_hsa030101.26869780
34Fatty acid biosynthesis_Homo sapiens_hsa000611.26616459
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24777589
36Retinol metabolism_Homo sapiens_hsa008301.22332987
37beta-Alanine metabolism_Homo sapiens_hsa004101.21114976
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17847367
39Axon guidance_Homo sapiens_hsa043601.16438740
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13362953
41Carbon metabolism_Homo sapiens_hsa012001.10047017
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.08930848
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08386015
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08244212
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07647068
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.02320629
47Tyrosine metabolism_Homo sapiens_hsa003500.97083699
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96909148
49ABC transporters_Homo sapiens_hsa020100.95283106
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93256572
51mRNA surveillance pathway_Homo sapiens_hsa030150.89761789
52Lysine degradation_Homo sapiens_hsa003100.87323278
53Arginine and proline metabolism_Homo sapiens_hsa003300.86879252
54Spliceosome_Homo sapiens_hsa030400.84362027
55AMPK signaling pathway_Homo sapiens_hsa041520.84356650
56Thyroid cancer_Homo sapiens_hsa052160.83707042
57Cell cycle_Homo sapiens_hsa041100.83395514
58Caffeine metabolism_Homo sapiens_hsa002320.83000073
59Phenylalanine metabolism_Homo sapiens_hsa003600.82793704
60Pyruvate metabolism_Homo sapiens_hsa006200.81294010
61Prion diseases_Homo sapiens_hsa050200.81040351
62Cardiac muscle contraction_Homo sapiens_hsa042600.77342182
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75920439
64Starch and sucrose metabolism_Homo sapiens_hsa005000.74337085
65Selenocompound metabolism_Homo sapiens_hsa004500.73115711
66Mismatch repair_Homo sapiens_hsa034300.72802539
67Basal cell carcinoma_Homo sapiens_hsa052170.68494895
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.67722143
69MicroRNAs in cancer_Homo sapiens_hsa052060.67536612
70GABAergic synapse_Homo sapiens_hsa047270.67520995
71Glutamatergic synapse_Homo sapiens_hsa047240.67059338
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65775976
73Dilated cardiomyopathy_Homo sapiens_hsa054140.65177067
74Glycerolipid metabolism_Homo sapiens_hsa005610.64562973
75Pentose phosphate pathway_Homo sapiens_hsa000300.64281177
76RNA transport_Homo sapiens_hsa030130.62818183
77Tight junction_Homo sapiens_hsa045300.62182841
78Hedgehog signaling pathway_Homo sapiens_hsa043400.61055393
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60872103
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60188357
81Hippo signaling pathway_Homo sapiens_hsa043900.60167999
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60002792
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.59369999
84Vitamin digestion and absorption_Homo sapiens_hsa049770.58537838
85Dorso-ventral axis formation_Homo sapiens_hsa043200.58491361
86DNA replication_Homo sapiens_hsa030300.56776860
87Melanoma_Homo sapiens_hsa052180.55197439
88Colorectal cancer_Homo sapiens_hsa052100.55101455
89Prostate cancer_Homo sapiens_hsa052150.54836758
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.54495926
91Basal transcription factors_Homo sapiens_hsa030220.52992890
92Insulin signaling pathway_Homo sapiens_hsa049100.52652315
93Protein export_Homo sapiens_hsa030600.52387005
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52216492
95Dopaminergic synapse_Homo sapiens_hsa047280.51465288
96Melanogenesis_Homo sapiens_hsa049160.51393674
97Gap junction_Homo sapiens_hsa045400.50718426
98ECM-receptor interaction_Homo sapiens_hsa045120.49937971
99TGF-beta signaling pathway_Homo sapiens_hsa043500.49503383
100Pathways in cancer_Homo sapiens_hsa052000.49283862
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48872750
102Glucagon signaling pathway_Homo sapiens_hsa049220.48272071
103Bladder cancer_Homo sapiens_hsa052190.48039126
104Staphylococcus aureus infection_Homo sapiens_hsa051500.47995563
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47953275
106Phototransduction_Homo sapiens_hsa047440.47911468
107Renin secretion_Homo sapiens_hsa049240.46268359
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45788729
109Long-term potentiation_Homo sapiens_hsa047200.45726323
110Circadian entrainment_Homo sapiens_hsa047130.45637267
111Amphetamine addiction_Homo sapiens_hsa050310.44696769
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43868469
113ErbB signaling pathway_Homo sapiens_hsa040120.43597202
114Fanconi anemia pathway_Homo sapiens_hsa034600.43501902
115Long-term depression_Homo sapiens_hsa047300.43392762
116Huntingtons disease_Homo sapiens_hsa050160.43115468
117Base excision repair_Homo sapiens_hsa034100.42526520
118Nicotine addiction_Homo sapiens_hsa050330.42171299
119Adherens junction_Homo sapiens_hsa045200.41356954
120Folate biosynthesis_Homo sapiens_hsa007900.41030856
121GnRH signaling pathway_Homo sapiens_hsa049120.40813329
122Cocaine addiction_Homo sapiens_hsa050300.40812373
123Thyroid hormone synthesis_Homo sapiens_hsa049180.39070884
124Wnt signaling pathway_Homo sapiens_hsa043100.38494484
125Endometrial cancer_Homo sapiens_hsa052130.38438787
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37990073
127Estrogen signaling pathway_Homo sapiens_hsa049150.36775999
128Insulin secretion_Homo sapiens_hsa049110.34604872
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32945203
130Salivary secretion_Homo sapiens_hsa049700.32750790
131Vitamin B6 metabolism_Homo sapiens_hsa007500.32413237
132Biosynthesis of amino acids_Homo sapiens_hsa012300.32272062
133Insulin resistance_Homo sapiens_hsa049310.32236682
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31742558
135Mineral absorption_Homo sapiens_hsa049780.31457944
136Protein digestion and absorption_Homo sapiens_hsa049740.30806897
137Glioma_Homo sapiens_hsa052140.30228515
138Serotonergic synapse_Homo sapiens_hsa047260.30025764

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