ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.78020762
2	chaperone mediated protein folding requiring cofactor (GO:0051085)	5.77385860
3	sequestering of actin monomers (GO:0042989)	5.54633730
4	sleep (GO:0030431)	5.09340301
5	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.79457066
6	cellular response to interleukin-15 (GO:0071350)	4.47744242
7	protein deneddylation (GO:0000338)	4.36008670
8	negative regulation of cell killing (GO:0031342)	4.32304356
9	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	4.32304356
10	metallo-sulfur cluster assembly (GO:0031163)	4.30938327
11	iron-sulfur cluster assembly (GO:0016226)	4.30938327
12	platelet dense granule organization (GO:0060155)	4.25730829
13	post-embryonic morphogenesis (GO:0009886)	4.17115073
14	regulation of memory T cell differentiation (GO:0043380)	4.13169983
15	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.99814800
16	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.88231765
17	negative regulation of interleukin-10 production (GO:0032693)	3.79831505
18	chaperone-mediated protein transport (GO:0072321)	3.79526244
19	positive regulation of osteoclast differentiation (GO:0045672)	3.78889722
20	negative regulation of meiotic cell cycle (GO:0051447)	3.72676297
21	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.64861128
22	adenosine metabolic process (GO:0046085)	3.61751225
23	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.56214692
24	regulation of mitotic spindle checkpoint (GO:1903504)	3.56214692
25	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.49365756
26	behavioral response to nicotine (GO:0035095)	3.45728073
27	preassembly of GPI anchor in ER membrane (GO:0016254)	3.44521988
28	S-adenosylmethionine metabolic process (GO:0046500)	3.42858847
29	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.42391260
30	positive regulation of heat generation (GO:0031652)	3.40274139
31	very-low-density lipoprotein particle assembly (GO:0034379)	3.37484886
32	regulation of gene silencing by RNA (GO:0060966)	3.37029755
33	regulation of posttranscriptional gene silencing (GO:0060147)	3.37029755
34	regulation of gene silencing by miRNA (GO:0060964)	3.37029755
35	negative regulation of meiosis (GO:0045835)	3.32802958
36	de novo posttranslational protein folding (GO:0051084)	3.31698352
37	protein localization to cilium (GO:0061512)	3.22521311
38	intraciliary transport (GO:0042073)	3.21980767
39	short-chain fatty acid metabolic process (GO:0046459)	3.19710059
40	regulation of activation of Janus kinase activity (GO:0010533)	3.17476814
41	folic acid metabolic process (GO:0046655)	3.16058628
42	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.13226876
43	glyoxylate metabolic process (GO:0046487)	3.12871563
44	fucose catabolic process (GO:0019317)	3.11461898
45	L-fucose metabolic process (GO:0042354)	3.11461898
46	L-fucose catabolic process (GO:0042355)	3.11461898
47	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	3.07850331
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.02906366
49	male sex determination (GO:0030238)	3.02615778
50	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.99494730
51	regulation of heat generation (GO:0031650)	2.98663042
52	mitochondrial DNA replication (GO:0006264)	2.97177666
53	regulation of development, heterochronic (GO:0040034)	2.96629572
54	interferon-gamma production (GO:0032609)	2.96590009
55	de novo protein folding (GO:0006458)	2.95032979
56	positive regulation of prostaglandin secretion (GO:0032308)	2.94770668
57	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.94196055
58	mitochondrial RNA metabolic process (GO:0000959)	2.90351955
59	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.89321742
60	regulation of fever generation (GO:0031620)	2.88608180
61	cytoplasmic sequestering of transcription factor (GO:0042994)	2.88544641
62	water-soluble vitamin biosynthetic process (GO:0042364)	2.84145171
63	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.82798228
64	response to interleukin-15 (GO:0070672)	2.81213048
65	protein-cofactor linkage (GO:0018065)	2.80424090
66	synapsis (GO:0007129)	2.80051834
67	positive regulation of defense response to virus by host (GO:0002230)	2.79691957
68	isoprenoid biosynthetic process (GO:0008299)	2.79499421
69	organic cation transport (GO:0015695)	2.75838211
70	lymph node development (GO:0048535)	2.74243744
71	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.73828184
72	auditory receptor cell stereocilium organization (GO:0060088)	2.73674734
73	cullin deneddylation (GO:0010388)	2.72501508
74	intestinal cholesterol absorption (GO:0030299)	2.71659167
75	negative regulation of gene silencing (GO:0060969)	2.71201222
76	fatty acid elongation (GO:0030497)	2.70769936
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70484463
78	inner ear receptor stereocilium organization (GO:0060122)	2.68995988
79	epithelial cilium movement (GO:0003351)	2.68831483
80	positive regulation of cholesterol transport (GO:0032376)	2.67896771
81	positive regulation of sterol transport (GO:0032373)	2.67896771
82	positive regulation of DNA repair (GO:0045739)	2.67407688
83	regulation of T cell mediated cytotoxicity (GO:0001914)	2.66360049
84	DNA damage induced protein phosphorylation (GO:0006975)	2.66201806
85	base-excision repair, AP site formation (GO:0006285)	2.64599076
86	serine family amino acid catabolic process (GO:0009071)	2.62971916
87	natural killer cell activation involved in immune response (GO:0002323)	2.61676173
88	cilium morphogenesis (GO:0060271)	2.60960665
89	DNA integration (GO:0015074)	2.60059311
90	regulation of cell fate commitment (GO:0010453)	2.59400123
91	rhodopsin mediated signaling pathway (GO:0016056)	2.59030384
92	protein insertion into membrane (GO:0051205)	2.55058577
93	L-serine metabolic process (GO:0006563)	2.54847461
94	amino acid salvage (GO:0043102)	2.54168256
95	L-methionine salvage (GO:0071267)	2.54168256
96	L-methionine biosynthetic process (GO:0071265)	2.54168256
97	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.53897779
98	positive regulation of receptor biosynthetic process (GO:0010870)	2.52598155
99	GPI anchor metabolic process (GO:0006505)	2.52061550
100	DNA deamination (GO:0045006)	2.49777641

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.77121457
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68119629
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.50969290
4	VDR_22108803_ChIP-Seq_LS180_Human	3.30608149
5	IRF1_19129219_ChIP-ChIP_H3396_Human	3.25824888
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.11162808
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.08366891
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.00279967
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.85586732
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.74028842
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57091278
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56494563
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.56347535
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.56216961
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.53444076
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.52936695
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.47040439
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30699387
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.22553135
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.11700804
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.09850299
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.07385150
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.06542050
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.03503434
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99635797
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.92996478
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.88211086
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.87555590
29	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.80696132
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.67321392
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64902602
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63341181
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.62275583
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.61434309
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53144498
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.51660455
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50904096
38	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.47350139
39	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.42115017
40	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.38475722
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35986163
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.33064232
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.32697105
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.32008176
45	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.29212821
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26645142
47	XRN2_22483619_ChIP-Seq_HELA_Human	1.21702447
48	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.19959344
49	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19871944
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18832722
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18117934
52	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.18066722
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.14795531
54	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.12630708
55	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.11834905
56	EWS_26573619_Chip-Seq_HEK293_Human	1.11597893
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11054082
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.10493439
59	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.09842178
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08802919
61	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.07597967
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06778417
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06054187
64	NCOR_22424771_ChIP-Seq_293T_Human	1.05792631
65	AR_20517297_ChIP-Seq_VCAP_Human	1.05106399
66	P300_19829295_ChIP-Seq_ESCs_Human	1.04125937
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04102882
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03249195
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02491306
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01357713
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.00787245
72	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.99847781
73	FUS_26573619_Chip-Seq_HEK293_Human	0.99830983
74	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.99034288
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98641788
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97487277
77	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97115116
78	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.95856431
79	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.95245163
80	TTF2_22483619_ChIP-Seq_HELA_Human	0.94889514
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94571730
82	CBP_20019798_ChIP-Seq_JUKART_Human	0.94571730
83	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92530245
84	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.92070917
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91835281
86	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.91079039
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91050267
88	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.90985187
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89578110
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89578110
91	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.89292177
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86937371
93	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.85652244
94	GBX2_23144817_ChIP-Seq_PC3_Human	0.85231179
95	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.84346854
96	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.83740501
97	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.83623703
98	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.83337720
99	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.82534451
100	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.81820234

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.56269857
2	MP0000566_synostosis	4.76746421
3	MP0006072_abnormal_retinal_apoptosis	4.29987538
4	MP0002102_abnormal_ear_morphology	3.85538517
5	MP0004147_increased_porphyrin_level	3.79928126
6	MP0003878_abnormal_ear_physiology	3.20222890
7	MP0005377_hearing/vestibular/ear_phenot	3.20222890
8	MP0008789_abnormal_olfactory_epithelium	3.13145705
9	MP0005394_taste/olfaction_phenotype	2.75730017
10	MP0005499_abnormal_olfactory_system	2.75730017
11	MP0010030_abnormal_orbit_morphology	2.72595563
12	MP0001293_anophthalmia	2.58985318
13	MP0008877_abnormal_DNA_methylation	2.50642875
14	MP0004133_heterotaxia	2.35731556
15	MP0004885_abnormal_endolymph	2.35478268
16	MP0001529_abnormal_vocalization	2.28100295
17	MP0002638_abnormal_pupillary_reflex	2.22768124
18	MP0002938_white_spotting	2.11402228
19	MP0005253_abnormal_eye_physiology	1.99899132
20	MP0005671_abnormal_response_to	1.97319439
21	MP0005171_absent_coat_pigmentation	1.97013407
22	MP0003938_abnormal_ear_development	1.94424323
23	MP0005075_abnormal_melanosome_morpholog	1.84251594
24	MP0003656_abnormal_erythrocyte_physiolo	1.70470710
25	MP0003136_yellow_coat_color	1.69590632
26	MP0000049_abnormal_middle_ear	1.60102892
27	MP0003646_muscle_fatigue	1.55504784
28	MP0001324_abnormal_eye_pigmentation	1.53045795
29	MP0010368_abnormal_lymphatic_system	1.46475666
30	MP0005391_vision/eye_phenotype	1.41119247
31	MP0003937_abnormal_limbs/digits/tail_de	1.39994815
32	MP0003195_calcinosis	1.37425031
33	MP0002233_abnormal_nose_morphology	1.37094334
34	MP0002876_abnormal_thyroid_physiology	1.34539420
35	MP0000026_abnormal_inner_ear	1.33110941
36	MP0002736_abnormal_nociception_after	1.32413215
37	MP0005551_abnormal_eye_electrophysiolog	1.25201043
38	MP0000647_abnormal_sebaceous_gland	1.22431847
39	MP0005084_abnormal_gallbladder_morpholo	1.19528339
40	MP0001188_hyperpigmentation	1.15626378
41	MP0005187_abnormal_penis_morphology	1.12396173
42	MP0008932_abnormal_embryonic_tissue	1.10766420
43	MP0003638_abnormal_response/metabolism_	1.08033404
44	MP0002139_abnormal_hepatobiliary_system	1.06062019
45	MP0001764_abnormal_homeostasis	1.05326243
46	MP0005248_abnormal_Harderian_gland	1.03860896
47	MP0006276_abnormal_autonomic_nervous	1.03750541
48	MP0005670_abnormal_white_adipose	1.02082596
49	MP0005365_abnormal_bile_salt	0.99393878
50	MP0000465_gastrointestinal_hemorrhage	0.99283766
51	MP0002822_catalepsy	0.98926618
52	MP0005646_abnormal_pituitary_gland	0.98776521
53	MP0001963_abnormal_hearing_physiology	0.94516710
54	MP0002752_abnormal_somatic_nervous	0.93597653
55	MP0000631_abnormal_neuroendocrine_gland	0.93007030
56	MP0002234_abnormal_pharynx_morphology	0.92375211
57	MP0001986_abnormal_taste_sensitivity	0.90816376
58	MP0005197_abnormal_uvea_morphology	0.90787601
59	MP0002277_abnormal_respiratory_mucosa	0.90467180
60	MP0000372_irregular_coat_pigmentation	0.88583829
61	MP0005195_abnormal_posterior_eye	0.87925876
62	MP0008995_early_reproductive_senescence	0.87679499
63	MP0003011_delayed_dark_adaptation	0.87218426
64	MP0002095_abnormal_skin_pigmentation	0.85420955
65	MP0010386_abnormal_urinary_bladder	0.83463519
66	MP0001286_abnormal_eye_development	0.82955992
67	MP0003283_abnormal_digestive_organ	0.81880124
68	MP0002092_abnormal_eye_morphology	0.80377535
69	MP0001968_abnormal_touch/_nociception	0.77679298
70	MP0005174_abnormal_tail_pigmentation	0.75766291
71	MP0002075_abnormal_coat/hair_pigmentati	0.75230507
72	MP0000462_abnormal_digestive_system	0.72842823
73	MP0001919_abnormal_reproductive_system	0.71791311
74	MP0000778_abnormal_nervous_system	0.71634371
75	MP0003755_abnormal_palate_morphology	0.69335315
76	MP0001502_abnormal_circadian_rhythm	0.68128422
77	MP0001177_atelectasis	0.67362111
78	MP0003119_abnormal_digestive_system	0.66466531
79	MP0009765_abnormal_xenobiotic_induced	0.65675812
80	MP0000538_abnormal_urinary_bladder	0.65477338
81	MP0008058_abnormal_DNA_repair	0.64865753
82	MP0001270_distended_abdomen	0.63910122
83	MP0005389_reproductive_system_phenotype	0.63874149
84	MP0003880_abnormal_central_pattern	0.63860920
85	MP0000762_abnormal_tongue_morphology	0.63537555
86	MP0003787_abnormal_imprinting	0.62703789
87	MP0001485_abnormal_pinna_reflex	0.62275376
88	MP0003879_abnormal_hair_cell	0.61047002
89	MP0002090_abnormal_vision	0.60705112
90	MP0008872_abnormal_physiological_respon	0.60525399
91	MP0002697_abnormal_eye_size	0.60169958
92	MP0005257_abnormal_intraocular_pressure	0.59627471
93	MP0010329_abnormal_lipoprotein_level	0.56549473
94	MP0002928_abnormal_bile_duct	0.56075504
95	MP0002751_abnormal_autonomic_nervous	0.54930935
96	MP0003828_pulmonary_edema	0.54008095
97	MP0001984_abnormal_olfaction	0.53666486
98	MP0002184_abnormal_innervation	0.52573223
99	MP0001119_abnormal_female_reproductive	0.51357119
100	MP0000428_abnormal_craniofacial_morphol	0.50659946

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.03185729
2	Brittle hair (HP:0002299)	3.96093659
3	Short tibia (HP:0005736)	3.88088764
4	Delayed CNS myelination (HP:0002188)	3.62805458
5	Aplasia/hypoplasia of the uterus (HP:0008684)	3.35994548
6	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.32592108
7	Pancreatic cysts (HP:0001737)	3.22464127
8	Persistence of primary teeth (HP:0006335)	3.08655130
9	Severe combined immunodeficiency (HP:0004430)	3.08395617
10	Nephronophthisis (HP:0000090)	2.91099983
11	Hypoplasia of the uterus (HP:0000013)	2.87180478
12	Humeroradial synostosis (HP:0003041)	2.80832866
13	Synostosis involving the elbow (HP:0003938)	2.80832866
14	Fibular aplasia (HP:0002990)	2.79274500
15	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.78717194
16	Renal cortical cysts (HP:0000803)	2.76169928
17	Abnormality of the middle phalanges of the toes (HP:0010183)	2.70923012
18	Supernumerary spleens (HP:0009799)	2.68702933
19	Methylmalonic acidemia (HP:0002912)	2.67543468
20	Progressive external ophthalmoplegia (HP:0000590)	2.65529218
21	Retinal dysplasia (HP:0007973)	2.62865261
22	Tongue fasciculations (HP:0001308)	2.57739307
23	Retrobulbar optic neuritis (HP:0100654)	2.55473048
24	Optic neuritis (HP:0100653)	2.55473048
25	Abnormality of eosinophils (HP:0001879)	2.53540429
26	IgG deficiency (HP:0004315)	2.44648794
27	Cortical dysplasia (HP:0002539)	2.39180513
28	Hyperglycinemia (HP:0002154)	2.37125305
29	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.35912274
30	Hypoplasia of the pons (HP:0012110)	2.35340679
31	Hypotrichosis (HP:0001006)	2.30280605
32	True hermaphroditism (HP:0010459)	2.29582612
33	Abnormal number of erythroid precursors (HP:0012131)	2.23663143
34	Chronic sinusitis (HP:0011109)	2.21540466
35	Medial flaring of the eyebrow (HP:0010747)	2.21399830
36	Type 2 muscle fiber atrophy (HP:0003554)	2.20744343
37	Abnormality of the pons (HP:0007361)	2.20297705
38	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.20116967
39	Muscle fibrillation (HP:0010546)	2.19846602
40	Progressive inability to walk (HP:0002505)	2.19697535
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15375724
42	Combined immunodeficiency (HP:0005387)	2.13057995
43	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.10581629
44	Slow-growing hair (HP:0002217)	2.07670549
45	Abnormality of hair growth rate (HP:0011363)	2.07670549
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.07629090
47	Abnormality of glycine metabolism (HP:0010895)	2.07629090
48	Pancreatic fibrosis (HP:0100732)	2.07085734
49	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.05381790
50	Thyroiditis (HP:0100646)	2.05283205
51	Occipital encephalocele (HP:0002085)	2.04755705
52	Recurrent bronchitis (HP:0002837)	2.04224767
53	Postaxial foot polydactyly (HP:0001830)	2.03313382
54	Prostate neoplasm (HP:0100787)	2.02512842
55	Fibular hypoplasia (HP:0003038)	2.02321099
56	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01069104
57	Abnormality of the renal medulla (HP:0100957)	1.99123713
58	Bile duct proliferation (HP:0001408)	1.98734713
59	Abnormal biliary tract physiology (HP:0012439)	1.98734713
60	Adactyly (HP:0009776)	1.98174111
61	External ophthalmoplegia (HP:0000544)	1.98151151
62	Carpal bone hypoplasia (HP:0001498)	1.97849613
63	Abnormality of the renal cortex (HP:0011035)	1.97470028
64	Amyotrophic lateral sclerosis (HP:0007354)	1.95093946
65	Concave nail (HP:0001598)	1.93370343
66	Abnormality of midbrain morphology (HP:0002418)	1.92211843
67	Molar tooth sign on MRI (HP:0002419)	1.92211843
68	Type I transferrin isoform profile (HP:0003642)	1.88612511
69	Postaxial hand polydactyly (HP:0001162)	1.88151537
70	Abnormality of the anterior horn cell (HP:0006802)	1.87202036
71	Degeneration of anterior horn cells (HP:0002398)	1.87202036
72	Muscle fiber atrophy (HP:0100295)	1.86070941
73	Adrenal hypoplasia (HP:0000835)	1.84882772
74	Conical tooth (HP:0000698)	1.84601644
75	Inability to walk (HP:0002540)	1.84031011
76	Pulmonary artery stenosis (HP:0004415)	1.82691337
77	Supernumerary bones of the axial skeleton (HP:0009144)	1.81698441
78	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.81544431
79	Hyperglycinuria (HP:0003108)	1.81489446
80	Coronal craniosynostosis (HP:0004440)	1.81380967
81	Congenital primary aphakia (HP:0007707)	1.79712223
82	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.78562510
83	Broad foot (HP:0001769)	1.78415883
84	Nephrogenic diabetes insipidus (HP:0009806)	1.77669211
85	Hypergonadotropic hypogonadism (HP:0000815)	1.77530574
86	Shoulder girdle muscle weakness (HP:0003547)	1.77105478
87	Bilateral sensorineural hearing impairment (HP:0008619)	1.76978364
88	Orchitis (HP:0100796)	1.76633965
89	Asplenia (HP:0001746)	1.74676299
90	Hemiparesis (HP:0001269)	1.74362319
91	Renal dysplasia (HP:0000110)	1.73955303
92	White forelock (HP:0002211)	1.73583884
93	Heterochromia iridis (HP:0001100)	1.72703727
94	Gait imbalance (HP:0002141)	1.71575584
95	Stage 5 chronic kidney disease (HP:0003774)	1.71560503
96	Bronchitis (HP:0012387)	1.69689588
97	Abolished electroretinogram (ERG) (HP:0000550)	1.68440930
98	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.67621807
99	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.67126556
100	Short 4th metacarpal (HP:0010044)	1.67126556

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	9.59181088
2	MAP4K2	4.10362882
3	GRK1	3.25549145
4	TAOK3	3.20166206
5	SRPK1	3.16851187
6	TXK	3.11800478
7	CDK19	2.83670044
8	SIK3	2.71088037
9	KDR	1.93750666
10	VRK2	1.78216302
11	WNK4	1.70925285
12	TLK1	1.65445868
13	ZAK	1.62074775
14	BMPR2	1.46441618
15	STK39	1.40133566
16	PRKD3	1.34246073
17	WNK3	1.27606436
18	EIF2AK1	1.23355633
19	DYRK3	1.23244432
20	MARK3	1.22176752
21	LMTK2	1.18393762
22	MAP2K2	1.14358267
23	MAP3K14	1.05452039
24	SIK2	1.01086812
25	MAP2K7	0.98844074
26	NUAK1	0.98709706
27	LIMK1	0.98501683
28	JAK3	0.94814076
29	BCR	0.93114457
30	RPS6KA4	0.92999687
31	TRIM28	0.92340988
32	DYRK2	0.88974340
33	CSNK1G3	0.88809727
34	CASK	0.84054161
35	KIT	0.83529732
36	BCKDK	0.83227861
37	IKBKE	0.82753010
38	EPHA3	0.81335523
39	ERBB3	0.79542425
40	SIK1	0.76833419
41	MATK	0.76337761
42	MKNK1	0.75734313
43	VRK1	0.75410971
44	INSRR	0.73510382
45	MAP3K4	0.73395713
46	TBK1	0.73093420
47	CSNK1G2	0.72577488
48	CSNK1A1L	0.71295618
49	IKBKB	0.68124435
50	MST4	0.67827668
51	CSNK1G1	0.66818148
52	MKNK2	0.65856250
53	GRK6	0.63075018
54	MAPKAPK3	0.58286061
55	EPHB2	0.57603679
56	EIF2AK2	0.53616746
57	EPHA4	0.53290292
58	FLT3	0.52109592
59	NEK6	0.47690418
60	OBSCN	0.47665839
61	ADRBK2	0.46716459
62	PASK	0.43495573
63	PHKG1	0.43302669
64	PHKG2	0.43302669
65	RPS6KA5	0.42497053
66	CCNB1	0.41582921
67	MAP3K9	0.41563952
68	DYRK1A	0.41329726
69	PAK6	0.40998206
70	PINK1	0.39811992
71	NTRK2	0.37765735
72	IGF1R	0.36669588
73	JAK1	0.36657465
74	MOS	0.36167017
75	PRKCE	0.36051385
76	DYRK1B	0.34739247
77	CAMK2B	0.33599083
78	MAP3K13	0.32759672
79	MAPK13	0.32389519
80	PLK3	0.31079766
81	FGR	0.30293353
82	MAP2K1	0.29768641
83	FES	0.29644499
84	DAPK1	0.29027945
85	TAF1	0.28704718
86	OXSR1	0.27600838
87	PLK2	0.27445508
88	CSNK2A1	0.26987554
89	PAK3	0.26930520
90	CSNK1A1	0.25687675
91	ALK	0.23638578
92	CHUK	0.23224413
93	MUSK	0.23173684
94	KSR1	0.22365783
95	PRKCQ	0.22119739
96	PKN1	0.21717331
97	PRKACB	0.21346857
98	TESK1	0.21150887
99	FER	0.20778259
100	IRAK2	0.19966071

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	4.03199536
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.82034734
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.72479443
4	Phototransduction_Homo sapiens_hsa04744	3.03612567
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.90584727
6	Fatty acid elongation_Homo sapiens_hsa00062	2.87806569
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.26549458
8	RNA polymerase_Homo sapiens_hsa03020	1.97528602
9	Basal transcription factors_Homo sapiens_hsa03022	1.94715107
10	Peroxisome_Homo sapiens_hsa04146	1.85456722
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.85102604
12	Folate biosynthesis_Homo sapiens_hsa00790	1.81053696
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.79569329
14	Butanoate metabolism_Homo sapiens_hsa00650	1.79163828
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.77268772
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.76990904
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.76800535
18	Circadian rhythm_Homo sapiens_hsa04710	1.71302525
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.68275909
20	Protein export_Homo sapiens_hsa03060	1.63573571
21	Propanoate metabolism_Homo sapiens_hsa00640	1.63499986
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62585975
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.58281551
24	Base excision repair_Homo sapiens_hsa03410	1.56491348
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.54149011
26	Homologous recombination_Homo sapiens_hsa03440	1.51145702
27	Proteasome_Homo sapiens_hsa03050	1.48844129
28	RNA degradation_Homo sapiens_hsa03018	1.47348979
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.37240689
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.36662187
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.30943393
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27060212
33	One carbon pool by folate_Homo sapiens_hsa00670	1.26700229
34	Spliceosome_Homo sapiens_hsa03040	1.26245154
35	Parkinsons disease_Homo sapiens_hsa05012	1.26206404
36	Regulation of autophagy_Homo sapiens_hsa04140	1.22911003
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.22060499
38	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.18323931
39	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.14394403
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.12622935
41	Caffeine metabolism_Homo sapiens_hsa00232	1.10428654
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.09460980
43	Purine metabolism_Homo sapiens_hsa00230	1.08642001
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.06631156
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04803134
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02132838
47	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.98275413
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95944690
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94034680
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89634904
51	Ribosome_Homo sapiens_hsa03010	0.86747918
52	Arginine and proline metabolism_Homo sapiens_hsa00330	0.83752547
53	Huntingtons disease_Homo sapiens_hsa05016	0.83306821
54	Metabolic pathways_Homo sapiens_hsa01100	0.82043307
55	Carbon metabolism_Homo sapiens_hsa01200	0.80848498
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80627471
57	RNA transport_Homo sapiens_hsa03013	0.77013056
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.74759967
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.74472120
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70950027
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69509517
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68646759
63	Taste transduction_Homo sapiens_hsa04742	0.68101803
64	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.67225843
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66725194
66	Basal cell carcinoma_Homo sapiens_hsa05217	0.66352649
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.66106944
68	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.59353634
69	Sulfur metabolism_Homo sapiens_hsa00920	0.58187039
70	Retinol metabolism_Homo sapiens_hsa00830	0.57832640
71	Fanconi anemia pathway_Homo sapiens_hsa03460	0.56246248
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.55407601
73	Phenylalanine metabolism_Homo sapiens_hsa00360	0.54928028
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.54902747
75	Glutathione metabolism_Homo sapiens_hsa00480	0.54597690
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47727880
77	Mismatch repair_Homo sapiens_hsa03430	0.46931537
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45525638
79	ABC transporters_Homo sapiens_hsa02010	0.43921907
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43869521
81	Alzheimers disease_Homo sapiens_hsa05010	0.42504161
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42294037
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41754672
84	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39245681
85	Asthma_Homo sapiens_hsa05310	0.38522296
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38297973
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37203906
88	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.35790523
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35714076
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.34896628
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34230265
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.31415486
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.31401305
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29515953
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.26823486
96	Chemical carcinogenesis_Homo sapiens_hsa05204	0.26679928
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.26052921
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25547855
99	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25147476
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.25098192

TLE1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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