TLE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.64365460
2locomotory exploration behavior (GO:0035641)3.53224936
3cerebellar granule cell differentiation (GO:0021707)3.52129284
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50052697
5cellular potassium ion homeostasis (GO:0030007)3.39383953
6sodium ion export (GO:0071436)3.27295262
7potassium ion homeostasis (GO:0055075)3.23568965
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18027567
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13092745
10layer formation in cerebral cortex (GO:0021819)3.12753384
11cerebellar Purkinje cell differentiation (GO:0021702)2.90575280
12cell communication by electrical coupling (GO:0010644)2.90232433
13vocalization behavior (GO:0071625)2.89967129
14synaptic vesicle maturation (GO:0016188)2.88521836
15negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88396344
16cell differentiation in hindbrain (GO:0021533)2.85048682
17cardiac muscle contraction (GO:0060048)2.84407207
18positive regulation of sodium ion transport (GO:0010765)2.82771117
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81548031
20positive regulation of synapse maturation (GO:0090129)2.80872886
21endothelial cell chemotaxis (GO:0035767)2.80217502
22cardiac conduction (GO:0061337)2.79027428
23gamma-aminobutyric acid transport (GO:0015812)2.76874301
24creatine metabolic process (GO:0006600)2.68223549
25dendritic spine organization (GO:0097061)2.67976591
26cardiac myofibril assembly (GO:0055003)2.67470335
27myofibril assembly (GO:0030239)2.66595465
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65683736
29auditory behavior (GO:0031223)2.64680701
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63522531
31synaptic vesicle exocytosis (GO:0016079)2.59373512
32regulation of neuronal synaptic plasticity (GO:0048168)2.58949050
33mating behavior (GO:0007617)2.58761814
34regulation of neurotransmitter levels (GO:0001505)2.58337031
35striated muscle contraction (GO:0006941)2.57589443
36neurotransmitter transport (GO:0006836)2.56178116
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56057639
38dendrite morphogenesis (GO:0048813)2.52627497
39detection of calcium ion (GO:0005513)2.52252856
40cardiac muscle hypertrophy in response to stress (GO:0014898)2.51968032
41muscle hypertrophy in response to stress (GO:0003299)2.51968032
42cardiac muscle adaptation (GO:0014887)2.51968032
43glucocorticoid metabolic process (GO:0008211)2.50761231
44cell migration in hindbrain (GO:0021535)2.50419355
45regulation of voltage-gated calcium channel activity (GO:1901385)2.48444971
46regulation of glutamate receptor signaling pathway (GO:1900449)2.45666790
47regulation of axon extension involved in axon guidance (GO:0048841)2.44363656
48C21-steroid hormone biosynthetic process (GO:0006700)2.44083889
49regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.43681306
50synaptic transmission, glutamatergic (GO:0035249)2.43446980
51glycine transport (GO:0015816)2.42813037
52synaptic vesicle endocytosis (GO:0048488)2.42632712
53neuromuscular synaptic transmission (GO:0007274)2.42584792
54negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41692948
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41681819
56regulation of synaptic vesicle exocytosis (GO:2000300)2.41398799
57glutamate secretion (GO:0014047)2.41224395
58neuronal action potential propagation (GO:0019227)2.40415825
59negative regulation of cell size (GO:0045792)2.39266776
60regulation of cell communication by electrical coupling (GO:0010649)2.38760939
61glutamate receptor signaling pathway (GO:0007215)2.38596819
62synaptic vesicle docking involved in exocytosis (GO:0016081)2.38431392
63potassium ion import (GO:0010107)2.37754799
64cardiac muscle hypertrophy (GO:0003300)2.37415220
65regulation of sodium ion transport (GO:0002028)2.36212716
66pattern specification involved in kidney development (GO:0061004)2.36151505
67neurotransmitter secretion (GO:0007269)2.35967251
68ionotropic glutamate receptor signaling pathway (GO:0035235)2.35834427
69cellular sodium ion homeostasis (GO:0006883)2.35318403
70regulation of sodium ion transmembrane transporter activity (GO:2000649)2.34990969
71positive regulation of dendrite development (GO:1900006)2.34296429
72neurotransmitter-gated ion channel clustering (GO:0072578)2.33828543
73regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.33365600
74postsynaptic membrane organization (GO:0001941)2.33218453
75regulation of heart rate by cardiac conduction (GO:0086091)2.32152477
76regulation of sodium ion transmembrane transport (GO:1902305)2.31526592
77regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31454202
78regulation of female receptivity (GO:0045924)2.30931538
79regulation of membrane repolarization (GO:0060306)2.30195895
80dopamine receptor signaling pathway (GO:0007212)2.29775261
81neuromuscular junction development (GO:0007528)2.29615464
82metanephric tubule development (GO:0072170)2.29360758
83metanephric nephron tubule development (GO:0072234)2.29360758
84cell-cell junction maintenance (GO:0045217)2.29219611
85regulation of long-term neuronal synaptic plasticity (GO:0048169)2.28930547
86chemosensory behavior (GO:0007635)2.28763260
87regulation of axon guidance (GO:1902667)2.28276466
88glucocorticoid biosynthetic process (GO:0006704)2.28143333
89negative regulation of hormone biosynthetic process (GO:0032353)2.27677515
90cellular response to catecholamine stimulus (GO:0071870)2.27664371
91cellular response to monoamine stimulus (GO:0071868)2.27664371
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.26415761
93mesenchymal-epithelial cell signaling (GO:0060638)2.25743008
94cell volume homeostasis (GO:0006884)2.24799650
95positive regulation of membrane potential (GO:0045838)2.24736083
96activation of protein kinase A activity (GO:0034199)2.24592516
97striated muscle hypertrophy (GO:0014897)2.24307246
98negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.23718519
99insulin-like growth factor receptor signaling pathway (GO:0048009)2.22726135
100exocrine pancreas development (GO:0031017)2.22570750
101cellular response to growth hormone stimulus (GO:0071378)2.22230402
102muscle filament sliding (GO:0030049)2.22025757
103actin-myosin filament sliding (GO:0033275)2.22025757
104positive regulation of gastrulation (GO:2000543)2.21095194
105peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.20291181
106negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.18975213
107toxin metabolic process (GO:0009404)2.17903145
108neuromuscular process controlling posture (GO:0050884)2.17017607
109growth hormone secretion (GO:0030252)2.15833012
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.15420064
111negative regulation of catenin import into nucleus (GO:0035414)2.15038343
112regulation of synapse maturation (GO:0090128)2.14909712
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.14818074
114sodium ion homeostasis (GO:0055078)2.14499598
115establishment of nucleus localization (GO:0040023)2.14080251
116long-term memory (GO:0007616)2.13427510
117exploration behavior (GO:0035640)2.12667207
118peptidyl-tyrosine autophosphorylation (GO:0038083)2.12260740
119protein targeting to plasma membrane (GO:0072661)2.11335231
120regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.09912835
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.08714305
122protein localization to synapse (GO:0035418)2.08193318
123estrogen biosynthetic process (GO:0006703)2.06937243
124regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.05815251
125regulation of ARF protein signal transduction (GO:0032012)2.04958070
126membrane repolarization (GO:0086009)2.04877999
127membrane depolarization during action potential (GO:0086010)2.04709552
128metanephric nephron epithelium development (GO:0072243)2.04228164
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.03913909
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.03438110
131cell communication involved in cardiac conduction (GO:0086065)2.03290789
132membrane tubulation (GO:0097320)2.03111691
133cell proliferation involved in metanephros development (GO:0072203)2.02870652
134neuronal ion channel clustering (GO:0045161)2.01913599
135proximal/distal pattern formation (GO:0009954)2.01203270
136membrane hyperpolarization (GO:0060081)2.00979642
137cellular response to cholesterol (GO:0071397)2.00376495
138positive regulation of potassium ion transmembrane transport (GO:1901381)1.99693790
139positive regulation of CREB transcription factor activity (GO:0032793)1.99185539
140regulation of synapse structural plasticity (GO:0051823)1.99155443
141cerebellar Purkinje cell layer development (GO:0021680)1.98597657
142regulation of synaptic vesicle transport (GO:1902803)1.98328985
143positive regulation of glycogen biosynthetic process (GO:0045725)1.97859288
144regulation of cholesterol homeostasis (GO:2000188)1.97055766
145dendritic spine morphogenesis (GO:0060997)1.96984298
146metanephric epithelium development (GO:0072207)1.96957987
147prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060521.95394965
148neuromuscular process controlling balance (GO:0050885)1.94729847
149regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.94597072
150suckling behavior (GO:0001967)1.94262906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87297932
2RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72956042
3EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72956042
4EZH2_22144423_ChIP-Seq_EOC_Human2.59253719
5DROSHA_22980978_ChIP-Seq_HELA_Human2.49956742
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49575097
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49352077
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47152053
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.44779901
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39563496
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38704359
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37323133
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36899942
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.32318860
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26142560
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21053034
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20827452
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17931820
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.14346554
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07893982
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.05372648
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01174069
23GBX2_23144817_ChIP-Seq_PC3_Human1.79212028
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74626462
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.67769893
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65237453
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63525642
28RACK7_27058665_Chip-Seq_MCF-7_Human1.63269435
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59916263
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57836704
31SMC4_20622854_ChIP-Seq_HELA_Human1.55649518
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55473701
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52455648
34KDM2B_26808549_Chip-Seq_K562_Human1.48729312
35* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46200077
36P68_20966046_ChIP-Seq_HELA_Human1.43110928
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.42241087
38WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41646569
39CREB1_26743006_Chip-Seq_LNCaP_Human1.36440668
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.34845139
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34393154
42REST_21632747_ChIP-Seq_MESCs_Mouse1.34371757
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.32301642
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31877624
45AR_21572438_ChIP-Seq_LNCaP_Human1.31023557
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30073525
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29210342
48SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28342362
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26531798
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26055270
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24774788
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24734199
53LXR_22292898_ChIP-Seq_THP-1_Human1.24377360
54* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23491457
55ZNF263_19887448_ChIP-Seq_K562_Human1.22774091
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21542638
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.21140368
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20168389
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.19934400
60* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18507063
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18287569
62* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17051849
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16629269
64* RING1B_27294783_Chip-Seq_NPCs_Mouse1.16104165
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16021461
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.12653259
67OCT4_19829295_ChIP-Seq_ESCs_Human1.12249545
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10765899
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10527379
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10213666
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.09899922
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09407289
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.07491668
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05968457
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05234348
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.04645017
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03910163
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02845422
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02533151
80AR_19668381_ChIP-Seq_PC3_Human1.02469299
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01880797
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.01868015
83TP63_22573176_ChIP-Seq_HFKS_Human1.01630743
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01556277
85* ISL1_27105846_Chip-Seq_CPCs_Mouse1.00565323
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.00492670
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99483745
88ZNF274_21170338_ChIP-Seq_K562_Hela0.99248394
89* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98584232
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.98560436
91* TCF7_22412390_ChIP-Seq_EML_Mouse0.98539883
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98264241
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98223658
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98210776
95* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97951653
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97194428
97AHR_22903824_ChIP-Seq_MCF-7_Human0.96392795
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96118814
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.96086999
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95208643
101MYC_27129775_Chip-Seq_CORNEA_Mouse0.95117632
102NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94734002
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.94326983
104RXR_22158963_ChIP-Seq_LIVER_Mouse0.94104681
105KLF4_19829295_ChIP-Seq_ESCs_Human0.93587995
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93318400
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.92388378
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.91128235
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.90895215
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.90872312
111TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90621636
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.90277849
113* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90274280
114TP53_23651856_ChIP-Seq_MEFs_Mouse0.90228892
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89550719
116TRIM28_21343339_ChIP-Seq_HEK293_Human0.89482301
117SOX2_21211035_ChIP-Seq_LN229_Gbm0.89386885
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88833356
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87633669
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86294228
121CTCF_27219007_Chip-Seq_Bcells_Human0.85925214
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.85869819
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.85869819
124STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85661757
125* KDM2B_26808549_Chip-Seq_DND41_Human0.83537386
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82898754
127SMAD4_21799915_ChIP-Seq_A2780_Human0.81192109
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80552805
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79710155
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79682067
131CLOCK_20551151_ChIP-Seq_293T_Human0.78310464
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78216854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity2.97761202
2MP0000566_synostosis2.64143546
3MP0003283_abnormal_digestive_organ2.50632797
4MP0005670_abnormal_white_adipose2.42454900
5MP0008569_lethality_at_weaning2.22388922
6MP0003635_abnormal_synaptic_transmissio2.19179108
7MP0004145_abnormal_muscle_electrophysio2.18681713
8MP0009046_muscle_twitch2.17995345
9MP0002909_abnormal_adrenal_gland2.05278795
10MP0005503_abnormal_tendon_morphology1.99610480
11MP0005083_abnormal_biliary_tract1.98539614
12MP0000751_myopathy1.95334339
13MP0004130_abnormal_muscle_cell1.85663327
14MP0004885_abnormal_endolymph1.83779986
15MP0000639_abnormal_adrenal_gland1.73575722
16MP0008438_abnormal_cutaneous_collagen1.67552554
17MP0001270_distended_abdomen1.67096029
18MP0001958_emphysema1.65459076
19MP0005409_darkened_coat_color1.63877389
20MP0005187_abnormal_penis_morphology1.63624887
21MP0002272_abnormal_nervous_system1.62266387
22MP0002822_catalepsy1.57880692
23MP0000534_abnormal_ureter_morphology1.57136270
24MP0002234_abnormal_pharynx_morphology1.56921676
25MP0001502_abnormal_circadian_rhythm1.53511172
26MP0006138_congestive_heart_failure1.52142674
27MP0003868_abnormal_feces_composition1.50196846
28MP0005167_abnormal_blood-brain_barrier1.48381337
29MP0002184_abnormal_innervation1.48345242
30MP0004858_abnormal_nervous_system1.48179032
31MP0001299_abnormal_eye_distance/1.47805752
32MP0009780_abnormal_chondrocyte_physiolo1.46680406
33MP0008961_abnormal_basal_metabolism1.46467802
34MP0000678_abnormal_parathyroid_gland1.45612458
35MP0002064_seizures1.45553794
36MP0009745_abnormal_behavioral_response1.42682772
37MP0005423_abnormal_somatic_nervous1.40978248
38MP0002089_abnormal_postnatal_growth/wei1.40345942
39MP0003122_maternal_imprinting1.39561093
40MP0010386_abnormal_urinary_bladder1.39486956
41MP0005375_adipose_tissue_phenotype1.37796249
42MP0005220_abnormal_exocrine_pancreas1.36584858
43MP0003329_amyloid_beta_deposits1.36450275
44MP0000955_abnormal_spinal_cord1.35418339
45MP0001348_abnormal_lacrimal_gland1.35132206
46MP0003137_abnormal_impulse_conducting1.31864853
47MP0005666_abnormal_adipose_tissue1.30662532
48MP0004036_abnormal_muscle_relaxation1.30151341
49MP0010368_abnormal_lymphatic_system1.29240217
50MP0004087_abnormal_muscle_fiber1.27400492
51MP0002067_abnormal_sensory_capabilities1.27259593
52MP0000749_muscle_degeneration1.25058130
53MP0003115_abnormal_respiratory_system1.24839365
54MP0003646_muscle_fatigue1.24641419
55MP0003942_abnormal_urinary_system1.24564856
56MP0001486_abnormal_startle_reflex1.23313645
57MP0004043_abnormal_pH_regulation1.23309374
58MP0002139_abnormal_hepatobiliary_system1.23253499
59MP0003252_abnormal_bile_duct1.22779171
60MP0004270_analgesia1.22041083
61MP0002108_abnormal_muscle_morphology1.21131192
62MP0001970_abnormal_pain_threshold1.21024614
63MP0002063_abnormal_learning/memory/cond1.20634333
64MP0005365_abnormal_bile_salt1.19508452
65MP0000759_abnormal_skeletal_muscle1.19333478
66MP0002557_abnormal_social/conspecific_i1.18407748
67MP0003279_aneurysm1.18003206
68MP0003385_abnormal_body_wall1.17481734
69MP0004215_abnormal_myocardial_fiber1.17363517
70MP0005369_muscle_phenotype1.16470313
71MP0005623_abnormal_meninges_morphology1.16384844
72MP0001177_atelectasis1.16268067
73MP0003195_calcinosis1.15319514
74MP0002572_abnormal_emotion/affect_behav1.13193009
75MP0002106_abnormal_muscle_physiology1.12643669
76MP0005620_abnormal_muscle_contractility1.12275191
77MP0005330_cardiomyopathy1.11800365
78MP0005535_abnormal_body_temperature1.09303960
79MP0000013_abnormal_adipose_tissue1.08690580
80MP0004272_abnormal_basement_membrane1.08152699
81MP0003045_fibrosis1.06419922
82MP0000778_abnormal_nervous_system1.04602138
83MP0002734_abnormal_mechanical_nocicepti1.03057794
84MP0010030_abnormal_orbit_morphology1.02139297
85MP0010234_abnormal_vibrissa_follicle1.01986501
86MP0003787_abnormal_imprinting1.01439668
87MP0004510_myositis1.00725859
88MP0002735_abnormal_chemical_nociception0.99689220
89MP0002249_abnormal_larynx_morphology0.98775790
90MP0000003_abnormal_adipose_tissue0.97867524
91MP0009250_abnormal_appendicular_skeleto0.97850354
92MP0003123_paternal_imprinting0.97666959
93MP0000579_abnormal_nail_morphology0.97000751
94MP0001849_ear_inflammation0.96733526
95MP0002896_abnormal_bone_mineralization0.96304440
96MP0003690_abnormal_glial_cell0.95843191
97MP0000920_abnormal_myelination0.95417156
98MP0000462_abnormal_digestive_system0.95169238
99MP0001666_abnormal_nutrient_absorption0.92637710
100MP0005275_abnormal_skin_tensile0.92155320
101MP0002882_abnormal_neuron_morphology0.92135082
102MP0000049_abnormal_middle_ear0.92102391
103MP0002938_white_spotting0.92026457
104MP0001968_abnormal_touch/_nociception0.91528090
105MP0002972_abnormal_cardiac_muscle0.91044577
106MP0003632_abnormal_nervous_system0.90826248
107MP0001664_abnormal_digestion0.90522679
108MP0001501_abnormal_sleep_pattern0.89554345
109MP0001944_abnormal_pancreas_morphology0.89134138
110MP0000681_abnormal_thyroid_gland0.89005001
111MP0005551_abnormal_eye_electrophysiolog0.88197784
112MP0003880_abnormal_central_pattern0.88116816
113MP0003633_abnormal_nervous_system0.86774682
114MP0006276_abnormal_autonomic_nervous0.86407948
115MP0000428_abnormal_craniofacial_morphol0.85719652
116MP0010329_abnormal_lipoprotein_level0.85280132
117MP0003879_abnormal_hair_cell0.85012065
118MP0002971_abnormal_brown_adipose0.84849190
119MP0005646_abnormal_pituitary_gland0.84301601
120MP0002066_abnormal_motor_capabilities/c0.83882142
121MP0005595_abnormal_vascular_smooth0.83609047
122MP0002837_dystrophic_cardiac_calcinosis0.82383792
123MP0004742_abnormal_vestibular_system0.82103283
124MP0004233_abnormal_muscle_weight0.81216807
125MP0001440_abnormal_grooming_behavior0.80977485
126MP0003634_abnormal_glial_cell0.80451920
127MP0004924_abnormal_behavior0.80279166
128MP0005386_behavior/neurological_phenoty0.80279166
129MP0003705_abnormal_hypodermis_morpholog0.80247103
130MP0002069_abnormal_eating/drinking_beha0.78571619
131MP0001765_abnormal_ion_homeostasis0.78401172
132MP0004085_abnormal_heartbeat0.77995420
133MP0001984_abnormal_olfaction0.77467256
134MP0001188_hyperpigmentation0.77233312
135MP0002269_muscular_atrophy0.77210705
136MP0008995_early_reproductive_senescence0.76957633
137MP0004811_abnormal_neuron_physiology0.76313385
138MP0004084_abnormal_cardiac_muscle0.76247540
139MP0000747_muscle_weakness0.75827137
140MP0010630_abnormal_cardiac_muscle0.75706245
141MP0009384_cardiac_valve_regurgitation0.75189775
142MP0001544_abnormal_cardiovascular_syste0.74640028
143MP0005385_cardiovascular_system_phenoty0.74640028
144MP0005448_abnormal_energy_balance0.74381625
145MP0002733_abnormal_thermal_nociception0.73879979
146MP0002090_abnormal_vision0.73726235
147MP0004484_altered_response_of0.73605307
148MP0002638_abnormal_pupillary_reflex0.72555118

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)5.49294523
2Obstructive sleep apnea (HP:0002870)5.45656992
3Shallow orbits (HP:0000586)3.92790144
4Muscle fiber splitting (HP:0003555)3.65174565
5Bundle branch block (HP:0011710)3.64441949
6Exercise-induced myalgia (HP:0003738)3.63094846
7Action tremor (HP:0002345)3.34534581
8Turricephaly (HP:0000262)3.29293736
9Protrusio acetabuli (HP:0003179)3.27581159
10Sleep apnea (HP:0010535)3.08814654
11Neoplasm of the heart (HP:0100544)3.02137212
12Hyporeflexia of lower limbs (HP:0002600)3.01916337
13Heart block (HP:0012722)2.94654758
14Sudden death (HP:0001699)2.91545261
15Muscle fiber inclusion bodies (HP:0100299)2.88982716
16Abnormal atrioventricular conduction (HP:0005150)2.85209142
17Ankle clonus (HP:0011448)2.83264605
18Progressive cerebellar ataxia (HP:0002073)2.82904049
19Visual hallucinations (HP:0002367)2.78078166
20Increased connective tissue (HP:0009025)2.77651316
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.73943923
22Round ear (HP:0100830)2.73816577
23Aplasia involving bones of the extremities (HP:0009825)2.72589660
24Aplasia involving bones of the upper limbs (HP:0009823)2.72589660
25Aplasia of the phalanges of the hand (HP:0009802)2.72589660
26Stridor (HP:0010307)2.72458962
27Nemaline bodies (HP:0003798)2.71586647
28Myotonia (HP:0002486)2.66398727
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.66084706
30Humeroradial synostosis (HP:0003041)2.63923974
31Synostosis involving the elbow (HP:0003938)2.63923974
32Distal lower limb muscle weakness (HP:0009053)2.60835417
33Enlarged penis (HP:0000040)2.60070678
34Mildly elevated creatine phosphokinase (HP:0008180)2.56742637
35Hypoventilation (HP:0002791)2.51685551
36Febrile seizures (HP:0002373)2.51659310
37Syncope (HP:0001279)2.51269219
38EMG: neuropathic changes (HP:0003445)2.51164535
39Visceral angiomatosis (HP:0100761)2.49826643
40Abnormality of the parietal bone (HP:0002696)2.40477985
41Myopathic facies (HP:0002058)2.40020550
42Supranuclear gaze palsy (HP:0000605)2.39755975
43Coronal craniosynostosis (HP:0004440)2.38021075
44Ankle contracture (HP:0006466)2.36566202
45Split foot (HP:0001839)2.35472280
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35324053
47Bladder diverticulum (HP:0000015)2.35244955
48Renal salt wasting (HP:0000127)2.34736704
49Elfin facies (HP:0004428)2.34717063
50Ventricular arrhythmia (HP:0004308)2.31568255
51Abnormality of the aortic arch (HP:0012303)2.30926198
52Overriding aorta (HP:0002623)2.30461815
53Trigonocephaly (HP:0000243)2.30161770
54Hyperacusis (HP:0010780)2.29509326
55Hemiplegia (HP:0002301)2.29437095
56Anteriorly placed anus (HP:0001545)2.29260423
57Asymmetric septal hypertrophy (HP:0001670)2.28110443
58Muscle hypertrophy of the lower extremities (HP:0008968)2.27690108
59Difficulty running (HP:0009046)2.26179430
60Agitation (HP:0000713)2.26115250
61Abnormality of binocular vision (HP:0011514)2.25009219
62Diplopia (HP:0000651)2.25009219
63Insomnia (HP:0100785)2.24805124
64Annular pancreas (HP:0001734)2.21484965
65Infantile muscular hypotonia (HP:0008947)2.20365960
66Renovascular hypertension (HP:0100817)2.20072848
67EMG: myopathic abnormalities (HP:0003458)2.18545022
68Abnormal EKG (HP:0003115)2.17893199
69Scanning speech (HP:0002168)2.16198485
70Increased variability in muscle fiber diameter (HP:0003557)2.15864471
71Truncal ataxia (HP:0002078)2.13416552
72Hemangiomatosis (HP:0007461)2.13238407
73Abnormality of the ischium (HP:0003174)2.13003343
74Abnormality of the calf musculature (HP:0001430)2.12668915
75Neurofibrillary tangles (HP:0002185)2.11742650
76Focal seizures (HP:0007359)2.11363010
77Atrioventricular block (HP:0001678)2.10683129
78Bronchomalacia (HP:0002780)2.08866537
79Buphthalmos (HP:0000557)2.08522545
80Megalencephaly (HP:0001355)2.08499383
81Genetic anticipation (HP:0003743)2.08167015
82Dysmetric saccades (HP:0000641)2.07802903
83Calf muscle hypertrophy (HP:0008981)2.06278740
84Prolonged QT interval (HP:0001657)2.06101332
85Torticollis (HP:0000473)2.05337789
86Atrial fibrillation (HP:0005110)2.02742074
87Intention tremor (HP:0002080)2.02598920
88Atrophic scars (HP:0001075)2.02442638
89Hypoplastic ischia (HP:0003175)2.01962360
90Hypercortisolism (HP:0001578)2.00977556
91Hyperkalemia (HP:0002153)2.00808017
92Short 4th metacarpal (HP:0010044)1.98366914
93Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98366914
94Long toe (HP:0010511)1.97003284
95J-shaped sella turcica (HP:0002680)1.96609428
96Macroorchidism (HP:0000053)1.96402837
97Premature rupture of membranes (HP:0001788)1.96323247
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.95575911
99Cerebral aneurysm (HP:0004944)1.95308837
100Ulnar deviation of the wrist (HP:0003049)1.95171043
101Ketoacidosis (HP:0001993)1.94360621
102Increased circulating renin level (HP:0000848)1.93627027
103Abnormal eating behavior (HP:0100738)1.93323838
104Broad face (HP:0000283)1.91850895
105Bowel diverticulosis (HP:0005222)1.90784617
106Spinal canal stenosis (HP:0003416)1.90327005
107Aortic dissection (HP:0002647)1.90167716
108Alacrima (HP:0000522)1.89109869
109Midline defect of the nose (HP:0004122)1.88648227
110Gout (HP:0001997)1.88222578
111Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88187813
112Flat cornea (HP:0007720)1.87801541
113Limb dystonia (HP:0002451)1.86858063
114Gaze-evoked nystagmus (HP:0000640)1.85982239
115Decreased circulating renin level (HP:0003351)1.85955314
116Thin bony cortex (HP:0002753)1.85832168
117Epileptic encephalopathy (HP:0200134)1.85353315
118Upper limb amyotrophy (HP:0009129)1.85150272
119Distal upper limb amyotrophy (HP:0007149)1.85150272
120Atonic seizures (HP:0010819)1.84981621
121Akinesia (HP:0002304)1.84856579
122Abnormality of renin-angiotensin system (HP:0000847)1.84745534
123Ventricular tachycardia (HP:0004756)1.84662121
124Bell-shaped thorax (HP:0001591)1.84483030
125Hip contracture (HP:0003273)1.84478298
126Primary atrial arrhythmia (HP:0001692)1.83399917
127Hand muscle atrophy (HP:0009130)1.82983091
128Congenital glaucoma (HP:0001087)1.81830254
129Depression (HP:0000716)1.80913942
130Difficulty climbing stairs (HP:0003551)1.80582209
131Ventricular fibrillation (HP:0001663)1.80477500
132Narrow palate (HP:0000189)1.80196599
133Lower limb amyotrophy (HP:0007210)1.79295466
134Anxiety (HP:0000739)1.78797572
135Neck muscle weakness (HP:0000467)1.78493056
136Abnormality of the diencephalon (HP:0010662)1.78246551
137Type 1 muscle fiber predominance (HP:0003803)1.78229464
138Renal duplication (HP:0000075)1.78172132
139Postural tremor (HP:0002174)1.77871475
140Dysdiadochokinesis (HP:0002075)1.77666828
141Right ventricular cardiomyopathy (HP:0011663)1.77333836
142Protruding ear (HP:0000411)1.77261580
143Lymphangioma (HP:0100764)1.76690785
144Status epilepticus (HP:0002133)1.76673724
145Foot dorsiflexor weakness (HP:0009027)1.76012785
146Supraventricular tachycardia (HP:0004755)1.75633417
147Abnormality of the 4th metacarpal (HP:0010012)1.75557201
148Postural instability (HP:0002172)1.75288535
149Abnormality of skeletal muscle fiber size (HP:0012084)1.75106988
150Distal lower limb amyotrophy (HP:0008944)1.74918700
151Nuclear cataract (HP:0100018)1.74895134
152Distal arthrogryposis (HP:0005684)1.74742916
153Narrow nasal bridge (HP:0000446)1.74104046
154Frequent falls (HP:0002359)1.72671632
155Generalized tonic-clonic seizures (HP:0002069)1.71488110
156Supraventricular arrhythmia (HP:0005115)1.71095441
157Hyperaldosteronism (HP:0000859)1.70913551
158Wrist flexion contracture (HP:0001239)1.70292362
159Abnormality of the foot musculature (HP:0001436)1.70157521
160Bulbar palsy (HP:0001283)1.69840777
161Exercise-induced muscle cramps (HP:0003710)1.69584008
162Focal dystonia (HP:0004373)1.69355522
163Congenital malformation of the right heart (HP:0011723)1.68982663
164Deep venous thrombosis (HP:0002625)1.67930469
165Aneurysm (HP:0002617)1.67566124
166Bowing of the arm (HP:0006488)1.67564726
167Bowed forearm bones (HP:0003956)1.67564726
168Myokymia (HP:0002411)1.67534644
169Hypoplastic nipples (HP:0002557)1.65640827
170Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.64816409
171Deviation of the hallux (HP:0010051)1.64537554
172Hyperextensible skin (HP:0000974)1.64467156
173Focal motor seizures (HP:0011153)1.64046613
174Short metatarsal (HP:0010743)1.63372726
175Abnormality of the middle phalanges of the toes (HP:0010183)1.63181479
176Ectopia lentis (HP:0001083)1.62826094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.02823614
2RIPK12.88444214
3TRIB32.51737023
4ERN12.40667346
5CAMKK22.21999252
6EPHA22.14759114
7EPHB12.04727161
8OBSCN2.01102929
9CAMK1G1.96067438
10FGFR21.95655543
11CAMKK11.93293440
12PDGFRA1.85901563
13WNK11.83274990
14PAK61.80318328
15PTK61.79205655
16DDR21.79070139
17INSRR1.63956648
18MAP3K71.59664673
19NTRK31.50304590
20EPHA41.48513784
21MAP2K61.44987855
22NTRK11.43835800
23PKN21.43376120
24MAPK151.43129659
25PHKG11.42358489
26PHKG21.42358489
27ICK1.37655325
28PTK21.36711211
29PRKD31.35922693
30CAMK11.34400279
31NME11.33352054
32STK381.33261594
33MAP3K61.30997748
34CAMK1D1.27757472
35RET1.27727128
36DAPK21.25739158
37CAMK41.22728518
38MARK21.20979805
39LMTK21.20057879
40CDC42BPA1.17280717
41MAP3K41.15752566
42FER1.14416304
43NTRK21.14250324
44WNK41.12910116
45CDK191.09024891
46PAK31.08140175
47RPS6KA21.06868901
48PINK11.05949268
49MAPKAPK51.01661566
50OXSR10.99610417
51PRKCH0.99064446
52HIPK20.98373980
53MAPKAPK30.97108108
54FGFR40.96777153
55MARK10.95556893
56TESK10.95453174
57PRKAA10.94205158
58CAMK2B0.94019418
59TNIK0.91517479
60MAP2K40.91472373
61TYRO30.90317279
62LATS10.89954882
63LATS20.89308225
64TIE10.88174662
65MYLK0.87644565
66MINK10.87348954
67PIK3CA0.86644952
68WNK30.84967141
69DMPK0.84434123
70TAOK30.83023747
71MUSK0.80902207
72PRKD10.80842997
73SGK2230.79889030
74SGK4940.79889030
75ERBB20.79206987
76SIK20.79139091
77PRKAA20.79117328
78PRKD20.78239396
79TTN0.77770102
80BCKDK0.77449580
81TNK20.77366985
82FGFR10.76509506
83SGK30.74311858
84KSR20.72886157
85NEK60.72822032
86EPHA30.72712922
87PDGFRB0.72467737
88UHMK10.70711540
89MST1R0.70668964
90CAMK2D0.70548899
91EPHB20.70057421
92CDK50.69545469
93FLT30.65300964
94MAP3K10.65184642
95ROCK10.64304441
96CAMK2A0.63107448
97SMG10.62905051
98CASK0.62661719
99CSNK1A1L0.62554005
100GRK50.62483175
101KIT0.61627434
102MAPK100.61255100
103MAP3K20.59346534
104EEF2K0.58493747
105RPS6KC10.58457857
106RPS6KL10.58457857
107ROCK20.58141726
108PRPF4B0.57919065
109MTOR0.57698754
110MAPK70.57047598
111STK390.56335447
112MAP2K20.54666702
113RPS6KA60.54557219
114MAPK40.54177686
115SGK20.54107513
116BMX0.53895056
117MAPK130.53842529
118SGK10.53233311
119MAP3K130.51415673
120MAPK120.50614838
121PRKCE0.50507067
122PKN10.50468882
123RPS6KA30.50186035
124MAP3K90.49057806
125MAPK80.48735209
126PAK20.48066492
127BRD40.47945977
128PDPK10.47850302
129MAP2K70.47669905
130CAMK2G0.47628876
131STK110.47395029
132FYN0.47032277
133DYRK1B0.46652472
134PDK10.45788705

Predicted pathways (KEGG)

RankGene SetZ-score
1Aldosterone synthesis and secretion_Homo sapiens_hsa049252.24851173
2Circadian entrainment_Homo sapiens_hsa047131.88105737
3Insulin secretion_Homo sapiens_hsa049111.86585090
4Nicotine addiction_Homo sapiens_hsa050331.84937526
5Glutamatergic synapse_Homo sapiens_hsa047241.82868790
6GABAergic synapse_Homo sapiens_hsa047271.82553601
7Nitrogen metabolism_Homo sapiens_hsa009101.74651960
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67326350
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.64795740
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55318068
11Salivary secretion_Homo sapiens_hsa049701.54725788
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.52650534
13Synaptic vesicle cycle_Homo sapiens_hsa047211.52578848
14Taste transduction_Homo sapiens_hsa047421.51824296
15Pancreatic secretion_Homo sapiens_hsa049721.50114975
16Morphine addiction_Homo sapiens_hsa050321.45125776
17Bile secretion_Homo sapiens_hsa049761.40867214
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40705126
19Gastric acid secretion_Homo sapiens_hsa049711.39838204
20Type II diabetes mellitus_Homo sapiens_hsa049301.39196963
21Cocaine addiction_Homo sapiens_hsa050301.34697919
22Ovarian steroidogenesis_Homo sapiens_hsa049131.26118162
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25956885
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23725367
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22245045
26Protein digestion and absorption_Homo sapiens_hsa049741.20657286
27Long-term potentiation_Homo sapiens_hsa047201.19616813
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18001791
29Cardiac muscle contraction_Homo sapiens_hsa042601.17223051
30Cholinergic synapse_Homo sapiens_hsa047251.17080199
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.16508336
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16023368
33Phenylalanine metabolism_Homo sapiens_hsa003601.13690970
34cAMP signaling pathway_Homo sapiens_hsa040241.13251212
35Renin secretion_Homo sapiens_hsa049241.12613670
36Fatty acid degradation_Homo sapiens_hsa000711.09141391
37Amphetamine addiction_Homo sapiens_hsa050311.08780288
38Long-term depression_Homo sapiens_hsa047301.07972220
39Fatty acid metabolism_Homo sapiens_hsa012121.07210233
40Dopaminergic synapse_Homo sapiens_hsa047281.03750393
41Hedgehog signaling pathway_Homo sapiens_hsa043401.03688663
42Dilated cardiomyopathy_Homo sapiens_hsa054141.03617827
43Lysine degradation_Homo sapiens_hsa003101.01724463
44Basal cell carcinoma_Homo sapiens_hsa052171.01440112
45Histidine metabolism_Homo sapiens_hsa003401.00978805
46Axon guidance_Homo sapiens_hsa043600.97287401
47Oxytocin signaling pathway_Homo sapiens_hsa049210.96226451
48Thyroid hormone synthesis_Homo sapiens_hsa049180.95999165
49Butanoate metabolism_Homo sapiens_hsa006500.95366945
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95104033
51Calcium signaling pathway_Homo sapiens_hsa040200.93663484
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93354875
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92790592
54mTOR signaling pathway_Homo sapiens_hsa041500.91917648
55Estrogen signaling pathway_Homo sapiens_hsa049150.91183813
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90672020
57VEGF signaling pathway_Homo sapiens_hsa043700.90264008
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88983215
59Melanogenesis_Homo sapiens_hsa049160.88244518
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87883743
61Gap junction_Homo sapiens_hsa045400.87468772
62Tight junction_Homo sapiens_hsa045300.87425265
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86454549
64Dorso-ventral axis formation_Homo sapiens_hsa043200.86392189
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.86055759
66GnRH signaling pathway_Homo sapiens_hsa049120.85507443
67Circadian rhythm_Homo sapiens_hsa047100.84999794
68Vitamin B6 metabolism_Homo sapiens_hsa007500.84759671
69ECM-receptor interaction_Homo sapiens_hsa045120.84478052
70Collecting duct acid secretion_Homo sapiens_hsa049660.84066760
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83318079
72Arginine and proline metabolism_Homo sapiens_hsa003300.80303567
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79654604
74Tryptophan metabolism_Homo sapiens_hsa003800.78630543
75ABC transporters_Homo sapiens_hsa020100.77459555
76Olfactory transduction_Homo sapiens_hsa047400.77230019
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.77021474
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75565648
79Fatty acid biosynthesis_Homo sapiens_hsa000610.73773027
80Vibrio cholerae infection_Homo sapiens_hsa051100.71827469
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.69125612
82Focal adhesion_Homo sapiens_hsa045100.68548409
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67733489
84Notch signaling pathway_Homo sapiens_hsa043300.66874251
85beta-Alanine metabolism_Homo sapiens_hsa004100.66863606
86PPAR signaling pathway_Homo sapiens_hsa033200.66108693
87Insulin resistance_Homo sapiens_hsa049310.66007520
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.65975397
89Serotonergic synapse_Homo sapiens_hsa047260.64885246
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62604225
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62400748
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.61542631
93Fatty acid elongation_Homo sapiens_hsa000620.60567450
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60121934
95Proteoglycans in cancer_Homo sapiens_hsa052050.59841999
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59293028
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.57829904
98Arginine biosynthesis_Homo sapiens_hsa002200.57822843
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.57641857
100Glioma_Homo sapiens_hsa052140.55899933
101Glucagon signaling pathway_Homo sapiens_hsa049220.55479357
102ErbB signaling pathway_Homo sapiens_hsa040120.55320655
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54896730
104MAPK signaling pathway_Homo sapiens_hsa040100.54894222
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53339500
106Propanoate metabolism_Homo sapiens_hsa006400.53250000
107AMPK signaling pathway_Homo sapiens_hsa041520.51870434
108Wnt signaling pathway_Homo sapiens_hsa043100.51590530
109Amoebiasis_Homo sapiens_hsa051460.50197887
110Ras signaling pathway_Homo sapiens_hsa040140.50099146
111Glycerolipid metabolism_Homo sapiens_hsa005610.48410710
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47381523
113Rap1 signaling pathway_Homo sapiens_hsa040150.46648431
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45924198
115Prion diseases_Homo sapiens_hsa050200.44682722
116Inositol phosphate metabolism_Homo sapiens_hsa005620.44046218
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.43659189
118Fructose and mannose metabolism_Homo sapiens_hsa000510.43390046
119Insulin signaling pathway_Homo sapiens_hsa049100.43041072
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42894636
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42125278
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.41552267
123Choline metabolism in cancer_Homo sapiens_hsa052310.41113917
124Tyrosine metabolism_Homo sapiens_hsa003500.38401913

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