TLE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.87140697
2negative regulation of histone methylation (GO:0031061)4.31211709
3regulation of gene silencing by RNA (GO:0060966)4.25523431
4regulation of posttranscriptional gene silencing (GO:0060147)4.25523431
5regulation of gene silencing by miRNA (GO:0060964)4.25523431
6nuclear pore organization (GO:0006999)3.77516203
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73191072
8nuclear pore complex assembly (GO:0051292)3.70483363
9olfactory bulb development (GO:0021772)3.67630137
10regulation of helicase activity (GO:0051095)3.65293593
11regulation of histone H3-K9 methylation (GO:0051570)3.64654086
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36043071
13epithelial cilium movement (GO:0003351)3.26957216
14DNA replication-dependent nucleosome organization (GO:0034723)3.26724055
15DNA replication-dependent nucleosome assembly (GO:0006335)3.26724055
16protein localization to kinetochore (GO:0034501)3.25494620
17positive regulation of chromosome segregation (GO:0051984)3.23440695
18cell proliferation in forebrain (GO:0021846)3.23010370
19regulation of RNA export from nucleus (GO:0046831)3.18175068
20mitotic metaphase plate congression (GO:0007080)3.12315965
21regulation of sister chromatid cohesion (GO:0007063)3.12187662
22outer ear morphogenesis (GO:0042473)3.11270706
23tongue development (GO:0043586)3.10358007
24cerebral cortex radially oriented cell migration (GO:0021799)3.09565530
25histone H4-K12 acetylation (GO:0043983)3.06388900
26peptidyl-arginine omega-N-methylation (GO:0035247)3.06024819
27pyrimidine nucleobase catabolic process (GO:0006208)3.04459521
28peptidyl-arginine N-methylation (GO:0035246)3.02815001
29peptidyl-arginine methylation (GO:0018216)3.02815001
30spermatid nucleus differentiation (GO:0007289)3.01511633
31mitotic nuclear envelope disassembly (GO:0007077)3.00351433
32neutrophil mediated immunity (GO:0002446)2.98905205
33cilium movement (GO:0003341)2.98004310
34limb development (GO:0060173)2.96215799
35appendage development (GO:0048736)2.96215799
36establishment of protein localization to Golgi (GO:0072600)2.95640473
37nuclear envelope disassembly (GO:0051081)2.94656846
38membrane disassembly (GO:0030397)2.94656846
39histone H2A monoubiquitination (GO:0035518)2.94397827
40activated T cell proliferation (GO:0050798)2.93057486
41negative regulation of chromatin modification (GO:1903309)2.92649624
42negative regulation of histone modification (GO:0031057)2.92116745
43cellular extravasation (GO:0045123)2.91739635
44histone arginine methylation (GO:0034969)2.91615453
45regulation of histone H3-K27 methylation (GO:0061085)2.91607392
46DNA unwinding involved in DNA replication (GO:0006268)2.91174852
47cranial nerve morphogenesis (GO:0021602)2.86328925
48mitotic sister chromatid cohesion (GO:0007064)2.86206531
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85481980
50negative regulation of cell killing (GO:0031342)2.85481980
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84182328
52positive regulation by organism of defense response of other organism involved in symbiotic interact2.84182328
53modulation by symbiont of host immune response (GO:0052553)2.84182328
54positive regulation by symbiont of host defense response (GO:0052509)2.84182328
55modulation by symbiont of host defense response (GO:0052031)2.84182328
56modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84182328
57somite development (GO:0061053)2.83914748
58pore complex assembly (GO:0046931)2.83084493
59protein targeting to Golgi (GO:0000042)2.82763737
60positive regulation of mitotic sister chromatid separation (GO:1901970)2.82011166
61positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82011166
62positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82011166
63determination of adult lifespan (GO:0008340)2.81400074
64mitotic sister chromatid segregation (GO:0000070)2.79822092
65cilium or flagellum-dependent cell motility (GO:0001539)2.79664729
66sister chromatid segregation (GO:0000819)2.79635667
67regulation of gene silencing (GO:0060968)2.78415239
68neuronal stem cell maintenance (GO:0097150)2.77816657
69neuron fate determination (GO:0048664)2.76962825
70histone H4-K5 acetylation (GO:0043981)2.76799064
71histone H4-K8 acetylation (GO:0043982)2.76799064
72histone H3-K9 methylation (GO:0051567)2.75750108
73metaphase plate congression (GO:0051310)2.72934216
74protein localization to chromosome, centromeric region (GO:0071459)2.71754242
75axonemal dynein complex assembly (GO:0070286)2.70967463
76neural tube formation (GO:0001841)2.70591746
77microglial cell activation (GO:0001774)2.70316721
78retrograde transport, vesicle recycling within Golgi (GO:0000301)2.69894165
79regulation of telomere maintenance via telomerase (GO:0032210)2.69363945
80nonmotile primary cilium assembly (GO:0035058)2.69263545
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69133466
82somatic hypermutation of immunoglobulin genes (GO:0016446)2.69133466
83DNA replication initiation (GO:0006270)2.69068486
84microtubule severing (GO:0051013)2.68656534
85regulation of centriole replication (GO:0046599)2.68519852
86regulation of translational termination (GO:0006449)2.68469567
87histone H3-K9 modification (GO:0061647)2.68406922
88regulation of nucleobase-containing compound transport (GO:0032239)2.67377458
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66597255
90regulation of cilium movement (GO:0003352)2.66562149
91cell migration in hindbrain (GO:0021535)2.65937341
92negative regulation of interleukin-12 production (GO:0032695)2.65326171
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64260324
94negative regulation of translation, ncRNA-mediated (GO:0040033)2.64260324
95regulation of translation, ncRNA-mediated (GO:0045974)2.64260324
96inner ear receptor cell development (GO:0060119)2.63267450
97myeloid leukocyte mediated immunity (GO:0002444)2.60687943
98maturation of SSU-rRNA (GO:0030490)2.57878770
99ventricular system development (GO:0021591)2.53755726
100ribosome assembly (GO:0042255)2.53093596
101presynaptic membrane assembly (GO:0097105)2.52579931
102attachment of spindle microtubules to kinetochore (GO:0008608)2.51589133
103regulation of spindle organization (GO:0090224)2.51578022
104artery development (GO:0060840)2.51238463
105embryonic body morphogenesis (GO:0010172)2.50704000
106regulation of chromosome segregation (GO:0051983)2.50116827
107mRNA splice site selection (GO:0006376)2.50014140
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.49971218
109establishment of chromosome localization (GO:0051303)2.49855347
110regulation of NFAT protein import into nucleus (GO:0051532)2.49491147
111centriole replication (GO:0007099)2.49449887
112histone H3-K4 trimethylation (GO:0080182)2.49040025
113radial glial cell differentiation (GO:0060019)2.48803899
114microtubule nucleation (GO:0007020)2.48786513
115protein polyglutamylation (GO:0018095)2.48216605
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46883888
117DNA geometric change (GO:0032392)2.46020404
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45850875
119head development (GO:0060322)2.45477876
120DNA duplex unwinding (GO:0032508)2.44727337
121histone H4-K16 acetylation (GO:0043984)2.44700768
122cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.44411746
123regulation of centrosome cycle (GO:0046605)2.44254643
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43492300
125NLS-bearing protein import into nucleus (GO:0006607)2.42172186
126regulation of histone methylation (GO:0031060)2.42163813
127negative regulation of chromosome organization (GO:2001251)2.42130344
128nucleobase biosynthetic process (GO:0046112)2.41965136
129leukocyte migration involved in inflammatory response (GO:0002523)2.41963610
130ribosome biogenesis (GO:0042254)2.40255539
131dosage compensation (GO:0007549)2.39145145
132locomotory exploration behavior (GO:0035641)2.38647936
133macrophage activation involved in immune response (GO:0002281)2.37789787
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37172502
135regulation of mitotic spindle organization (GO:0060236)2.36763383
136kinetochore organization (GO:0051383)2.36060732
137cardiovascular system development (GO:0072358)2.35677971
138proximal/distal pattern formation (GO:0009954)2.35481893
139positive regulation of gamma-delta T cell activation (GO:0046645)2.35457953
140negative regulation of oligodendrocyte differentiation (GO:0048715)2.35221138
141negative regulation of alpha-beta T cell differentiation (GO:0046639)2.34463572
142DNA replication-independent nucleosome assembly (GO:0006336)2.34383207
143DNA replication-independent nucleosome organization (GO:0034724)2.34383207
144histone H3-K36 demethylation (GO:0070544)2.34121363
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.34077626
146presynaptic membrane organization (GO:0097090)2.33092953
147response to histamine (GO:0034776)2.32843314
148dendrite development (GO:0016358)2.32635886
149kinetochore assembly (GO:0051382)2.32334641
150replication fork processing (GO:0031297)2.31849957
151negative regulation of DNA recombination (GO:0045910)2.31698135
152regulation of DNA methylation (GO:0044030)2.31696881
153spindle checkpoint (GO:0031577)2.31576562
154negative regulation of histone acetylation (GO:0035067)2.31424101
155negative regulation of chromosome segregation (GO:0051985)2.30943725
156protein localization to chromosome (GO:0034502)2.30694507
157anterior/posterior axis specification, embryo (GO:0008595)2.30377837
158heterochromatin organization (GO:0070828)2.29843175
159intraciliary transport (GO:0042073)2.28979613
160regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28777911
161negative regulation of inclusion body assembly (GO:0090084)2.28543958
162DNA replication checkpoint (GO:0000076)2.28215858
163mitotic chromosome condensation (GO:0007076)2.28112991
164axonal fasciculation (GO:0007413)2.27926178
165regulation of mitotic metaphase/anaphase transition (GO:0030071)2.27440249
166chromatin assembly or disassembly (GO:0006333)2.26113783
167negative regulation of Rho protein signal transduction (GO:0035024)2.26063749
168nuclear envelope organization (GO:0006998)2.26031016
169negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.25849401
170viral transcription (GO:0019083)2.25824794
171lateral sprouting from an epithelium (GO:0060601)2.25227084
172spinal cord development (GO:0021510)2.24691589
173central nervous system projection neuron axonogenesis (GO:0021952)2.24532810
174retinal ganglion cell axon guidance (GO:0031290)2.23619609
175regulation of MHC class II biosynthetic process (GO:0045346)2.23328928
176response to peptidoglycan (GO:0032494)2.21419112
177negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.21158664
178detection of molecule of bacterial origin (GO:0032490)2.20645227
179regulation of neuroblast proliferation (GO:1902692)2.20144831
180left/right pattern formation (GO:0060972)2.20026019
181RNA destabilization (GO:0050779)2.19562211
182regulation of T-helper 2 cell differentiation (GO:0045628)2.19322697
183acrosome reaction (GO:0007340)2.18014967
184positive regulation of microtubule polymerization (GO:0031116)2.17586691
185neuron recognition (GO:0008038)2.17541532
186microtubule depolymerization (GO:0007019)2.16484161
187positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.16326375
188regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.16050073
189forebrain neuron differentiation (GO:0021879)2.14135582
190ribosomal small subunit assembly (GO:0000028)2.14080953
191negative regulation of granulocyte differentiation (GO:0030853)2.13046980
192positive regulation of gastrulation (GO:2000543)2.11921891
193seminiferous tubule development (GO:0072520)2.11537198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.71727183
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75314889
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51999477
4* SALL1_21062744_ChIP-ChIP_HESCs_Human3.28161742
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.25805828
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.06791132
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.88291173
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.88291173
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.88291173
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77469661
11SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.73014974
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.72215174
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70919911
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.59988937
15* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.54624350
16* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46378176
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41856406
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28683124
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.22111815
20TAF15_26573619_Chip-Seq_HEK293_Human2.21110615
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17216334
22* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.15838357
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11882163
24GBX2_23144817_ChIP-Seq_PC3_Human2.06472221
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.04974773
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03917646
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01094110
28* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00904372
29* POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.00904372
30MYC_22102868_ChIP-Seq_BL_Human2.00595313
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95050770
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.93720491
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.92099076
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90988678
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87173110
36* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86783220
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86133684
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85803315
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80928362
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.78952470
41* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.78815079
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78278964
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75967155
44IGF1R_20145208_ChIP-Seq_DFB_Human1.74890974
45* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74668432
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.73018502
47* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72725353
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70870112
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69055663
50* P300_19829295_ChIP-Seq_ESCs_Human1.68605860
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.66657930
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65467397
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.59078494
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.58775525
55* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57355634
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56041242
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55882283
58* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54806561
59* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54241771
60AR_21909140_ChIP-Seq_LNCAP_Human1.49867552
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.48058091
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.46869667
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45531666
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44757719
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44110590
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44036644
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43536984
68IRF1_19129219_ChIP-ChIP_H3396_Human1.43208408
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42671351
70* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42463948
71* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41976249
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41666605
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41487922
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39471135
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39288199
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38751201
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38526413
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38241333
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37059183
80* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36779239
81CIITA_25753668_ChIP-Seq_RAJI_Human1.35917933
82* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35736087
83* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.34397572
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34268639
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.33582653
86SMAD4_21799915_ChIP-Seq_A2780_Human1.32337142
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.30623462
88TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.30569106
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29813298
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29650108
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28908999
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.28644944
93* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28596407
94* SMAD3_21741376_ChIP-Seq_EPCs_Human1.27579088
95* XRN2_22483619_ChIP-Seq_HELA_Human1.26319415
96ZNF274_21170338_ChIP-Seq_K562_Hela1.26044523
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25835926
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.25327630
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24640293
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24293132
101* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24097645
102* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23248819
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22830975
104EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22671734
105RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22671734
106* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22266418
107* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21281957
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21053702
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20318492
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19052001
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18861773
112* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18819199
113CBP_20019798_ChIP-Seq_JUKART_Human1.17738351
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17738351
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16717849
116* TTF2_22483619_ChIP-Seq_HELA_Human1.16326542
117* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16291924
118TP53_16413492_ChIP-PET_HCT116_Human1.16288819
119* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16119315
120* RUNX2_22187159_ChIP-Seq_PCA_Human1.16009694
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15873151
122* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15230760
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15213010
124* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14539943
125* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14288321
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.13865865
127* STAT3_23295773_ChIP-Seq_U87_Human1.13091891
128* RUNX_20019798_ChIP-Seq_JUKART_Human1.12984269
129REST_21632747_ChIP-Seq_MESCs_Mouse1.12908690
130GATA1_26923725_Chip-Seq_HPCs_Mouse1.12409784
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.12047688
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12005770
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.10794879
134AR_25329375_ChIP-Seq_VCAP_Human1.09862851
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09339858
136TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08785191
137EZH2_22144423_ChIP-Seq_EOC_Human1.08539815
138* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06852818
139* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06667167
140* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06643015
141EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05854433
142MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05293219
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04640930
144* ISL1_27105846_Chip-Seq_CPCs_Mouse1.03892612
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03247806
146* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03182812
147POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02882152
148* VDR_23849224_ChIP-Seq_CD4+_Human1.01983053
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01929798
150* PIAS1_25552417_ChIP-Seq_VCAP_Human1.01758797
151EWS_26573619_Chip-Seq_HEK293_Human1.01462036
152SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01245104
153* PRDM14_20953172_ChIP-Seq_ESCs_Human1.01235807
154* NANOG_16518401_ChIP-PET_MESCs_Mouse1.01006233
155BP1_19119308_ChIP-ChIP_Hs578T_Human1.00781566
156* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00548174
157CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99876629
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.99856559
159* VDR_24787735_ChIP-Seq_THP-1_Human0.99424802
160IRF8_21731497_ChIP-ChIP_J774_Mouse0.99259554
161SOX2_16153702_ChIP-ChIP_HESCs_Human0.98832229
162ETS1_20019798_ChIP-Seq_JURKAT_Human0.97381284
163TP53_18474530_ChIP-ChIP_U2OS_Human0.96998610
164* KDM2B_26808549_Chip-Seq_REH_Human0.96682742
165RXR_22108803_ChIP-Seq_LS180_Human0.96645327
166ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96633703
167* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96455038
168DROSHA_22980978_ChIP-Seq_HELA_Human0.95516912
169* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94757724
170FLI1_27457419_Chip-Seq_LIVER_Mouse0.94411561
171ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93633179
172TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93442079
173* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91153036
174* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91018414
175KDM5A_27292631_Chip-Seq_BREAST_Human0.90955416
176* TCF7_22412390_ChIP-Seq_EML_Mouse0.90578567
177* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90404311
178NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89967034
179* FUS_26573619_Chip-Seq_HEK293_Human0.89890156
180ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89870132
181TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89832829
182* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88236195
183* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87340780
184FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86947360
185KDM2B_26808549_Chip-Seq_DND41_Human0.83534161
186RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81936952
187EST1_17652178_ChIP-ChIP_JURKAT_Human0.81091192
188ZNF263_19887448_ChIP-Seq_K562_Human0.79681350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.19504128
2MP0003111_abnormal_nucleus_morphology3.05451256
3MP0003693_abnormal_embryo_hatching3.00533767
4MP0004859_abnormal_synaptic_plasticity2.97272766
5MP0010094_abnormal_chromosome_stability2.92537188
6MP0004957_abnormal_blastocyst_morpholog2.81217657
7MP0010030_abnormal_orbit_morphology2.63985365
8MP0003077_abnormal_cell_cycle2.60838880
9MP0005248_abnormal_Harderian_gland2.51170813
10MP0008789_abnormal_olfactory_epithelium2.41033291
11MP0003123_paternal_imprinting2.38974907
12MP0005377_hearing/vestibular/ear_phenot2.29510124
13MP0003878_abnormal_ear_physiology2.29510124
14MP0003122_maternal_imprinting2.18253376
15MP0009379_abnormal_foot_pigmentation2.11674996
16MP0010234_abnormal_vibrissa_follicle2.10368153
17MP0000049_abnormal_middle_ear2.09515229
18MP0008058_abnormal_DNA_repair2.08375180
19MP0010352_gastrointestinal_tract_polyps2.00377768
20MP0002822_catalepsy1.97345370
21MP0003121_genomic_imprinting1.93323240
22MP0002653_abnormal_ependyma_morphology1.90633912
23MP0008877_abnormal_DNA_methylation1.88961873
24MP0003635_abnormal_synaptic_transmissio1.84441825
25MP0003787_abnormal_imprinting1.83083979
26MP0003724_increased_susceptibility_to1.80149238
27MP0000350_abnormal_cell_proliferation1.77038182
28MP0010307_abnormal_tumor_latency1.75284895
29MP0004142_abnormal_muscle_tone1.72601911
30MP0001730_embryonic_growth_arrest1.72307441
31MP0002063_abnormal_learning/memory/cond1.71156248
32MP0005076_abnormal_cell_differentiation1.68209038
33MP0009053_abnormal_anal_canal1.68076834
34MP0002084_abnormal_developmental_patter1.58778102
35MP0003880_abnormal_central_pattern1.55758565
36MP0000428_abnormal_craniofacial_morphol1.48879121
37MP0009745_abnormal_behavioral_response1.45934627
38MP0002085_abnormal_embryonic_tissue1.45704400
39MP0004270_analgesia1.43915439
40MP0001697_abnormal_embryo_size1.42988508
41MP0003941_abnormal_skin_development1.42794135
42MP0001440_abnormal_grooming_behavior1.40011663
43MP0001672_abnormal_embryogenesis/_devel1.39883644
44MP0005380_embryogenesis_phenotype1.39883644
45MP0002572_abnormal_emotion/affect_behav1.38621009
46MP0000569_abnormal_digit_pigmentation1.34140168
47MP0002086_abnormal_extraembryonic_tissu1.33431626
48MP0003755_abnormal_palate_morphology1.33186223
49MP0000778_abnormal_nervous_system1.32757595
50MP0002064_seizures1.31668481
51MP0002233_abnormal_nose_morphology1.31306958
52MP0001968_abnormal_touch/_nociception1.30893801
53MP0003890_abnormal_embryonic-extraembry1.30094453
54MP0003646_muscle_fatigue1.29667840
55MP0003828_pulmonary_edema1.27048186
56MP0003119_abnormal_digestive_system1.26834790
57MP0003861_abnormal_nervous_system1.25021093
58MP0001346_abnormal_lacrimal_gland1.24501203
59MP0006292_abnormal_olfactory_placode1.21904280
60MP0003937_abnormal_limbs/digits/tail_de1.21156808
61MP0003136_yellow_coat_color1.19167021
62MP0008007_abnormal_cellular_replicative1.19137555
63MP0002102_abnormal_ear_morphology1.18444365
64MP0001486_abnormal_startle_reflex1.17860775
65MP0002396_abnormal_hematopoietic_system1.17111985
66MP0001984_abnormal_olfaction1.16475204
67MP0003984_embryonic_growth_retardation1.14501755
68MP0002088_abnormal_embryonic_growth/wei1.14331116
69MP0004197_abnormal_fetal_growth/weight/1.14284143
70MP0000631_abnormal_neuroendocrine_gland1.14046047
71MP0002092_abnormal_eye_morphology1.13905580
72MP0002080_prenatal_lethality1.13882584
73MP0008932_abnormal_embryonic_tissue1.13391515
74MP0002733_abnormal_thermal_nociception1.12132005
75MP0004742_abnormal_vestibular_system1.11866225
76MP0003942_abnormal_urinary_system1.09556919
77MP0001485_abnormal_pinna_reflex1.08074488
78MP0005410_abnormal_fertilization1.06597764
79MP0001188_hyperpigmentation1.06060672
80MP0001299_abnormal_eye_distance/1.05998567
81MP0002152_abnormal_brain_morphology1.04263313
82MP0005423_abnormal_somatic_nervous1.01955861
83MP0004858_abnormal_nervous_system1.01855626
84MP0004811_abnormal_neuron_physiology1.00871985
85MP0000026_abnormal_inner_ear1.00032071
86MP0008961_abnormal_basal_metabolism0.98424728
87MP0003786_premature_aging0.97566461
88MP0009046_muscle_twitch0.97362583
89MP0002752_abnormal_somatic_nervous0.97189814
90MP0001293_anophthalmia0.97128952
91MP0005391_vision/eye_phenotype0.96403975
92MP0002116_abnormal_craniofacial_bone0.94858300
93MP0000703_abnormal_thymus_morphology0.94459012
94MP0004133_heterotaxia0.94186451
95MP0002277_abnormal_respiratory_mucosa0.93513017
96MP0003567_abnormal_fetal_cardiomyocyte0.93443179
97MP0001963_abnormal_hearing_physiology0.93290455
98MP0001849_ear_inflammation0.91798020
99MP0001835_abnormal_antigen_presentation0.91065143
100MP0000516_abnormal_urinary_system0.90716003
101MP0005367_renal/urinary_system_phenotyp0.90716003
102MP0000566_synostosis0.90006804
103MP0004808_abnormal_hematopoietic_stem0.89307351
104MP0008770_decreased_survivor_rate0.88992002
105MP0005503_abnormal_tendon_morphology0.88182110
106MP0002249_abnormal_larynx_morphology0.87902707
107MP0002697_abnormal_eye_size0.87901337
108MP0003698_abnormal_male_reproductive0.87627136
109MP0002734_abnormal_mechanical_nocicepti0.87509510
110MP0001970_abnormal_pain_threshold0.87476954
111MP0002272_abnormal_nervous_system0.86592332
112MP0002938_white_spotting0.86588779
113MP0006072_abnormal_retinal_apoptosis0.86325869
114MP0002557_abnormal_social/conspecific_i0.85886434
115MP0005195_abnormal_posterior_eye0.85866191
116MP0001529_abnormal_vocalization0.85399607
117MP0002109_abnormal_limb_morphology0.83846139
118MP0003938_abnormal_ear_development0.83323717
119MP0000955_abnormal_spinal_cord0.83312534
120MP0002398_abnormal_bone_marrow0.82760950
121MP0003385_abnormal_body_wall0.82705817
122MP0002210_abnormal_sex_determination0.82256193
123MP0003303_peritoneal_inflammation0.81833544
124MP0002184_abnormal_innervation0.81747312
125MP0002095_abnormal_skin_pigmentation0.81142152
126MP0000490_abnormal_crypts_of0.80293805
127MP0000534_abnormal_ureter_morphology0.80195859
128MP0009250_abnormal_appendicular_skeleto0.80149770
129MP0001324_abnormal_eye_pigmentation0.79333834
130MP0003315_abnormal_perineum_morphology0.79273507
131MP0002009_preneoplasia0.78550568
132MP0000313_abnormal_cell_death0.78288721
133MP0006276_abnormal_autonomic_nervous0.78070099
134MP0003436_decreased_susceptibility_to0.77341814
135MP0002019_abnormal_tumor_incidence0.76971754
136MP0001800_abnormal_humoral_immune0.76835542
137MP0002928_abnormal_bile_duct0.76747751
138MP0002081_perinatal_lethality0.76341585
139MP0005386_behavior/neurological_phenoty0.76077808
140MP0004924_abnormal_behavior0.76077808
141MP0001145_abnormal_male_reproductive0.74989410
142MP0005394_taste/olfaction_phenotype0.71994955
143MP0005499_abnormal_olfactory_system0.71994955
144MP0002419_abnormal_innate_immunity0.71725724
145MP0001929_abnormal_gametogenesis0.71030605
146MP0010678_abnormal_skin_adnexa0.70604333
147MP0002067_abnormal_sensory_capabilities0.70390251
148MP0003935_abnormal_craniofacial_develop0.70364927
149MP0002882_abnormal_neuron_morphology0.70364879
150MP0009703_decreased_birth_body0.69880296
151MP0005310_abnormal_salivary_gland0.69789735
152MP0002722_abnormal_immune_system0.69657898
153MP0002736_abnormal_nociception_after0.69530319
154MP0004885_abnormal_endolymph0.68723683
155MP0009278_abnormal_bone_marrow0.66697111
156MP0006082_CNS_inflammation0.66161897
157MP0003763_abnormal_thymus_physiology0.65958453
158MP0001286_abnormal_eye_development0.64757910
159MP0005174_abnormal_tail_pigmentation0.63215008
160MP0002751_abnormal_autonomic_nervous0.63208085

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.56347369
2Ependymoma (HP:0002888)3.47153137
3Birth length less than 3rd percentile (HP:0003561)3.17949613
4Abnormality of the 4th metacarpal (HP:0010012)3.13471464
5Pancreatic fibrosis (HP:0100732)3.06370395
6Septo-optic dysplasia (HP:0100842)3.03465730
7Agnosia (HP:0010524)2.99168277
8Medulloblastoma (HP:0002885)2.94429992
9Neoplasm of the oral cavity (HP:0100649)2.93888110
10Astrocytoma (HP:0009592)2.84080763
11Abnormality of the astrocytes (HP:0100707)2.84080763
12Abnormal ciliary motility (HP:0012262)2.73747327
13Hypoplastic ischia (HP:0003175)2.62852929
14Colon cancer (HP:0003003)2.62493353
15Partial duplication of thumb phalanx (HP:0009944)2.60730158
16True hermaphroditism (HP:0010459)2.56259208
17Partial duplication of the phalanx of hand (HP:0009999)2.56177987
18Abnormality of the phalanges of the hallux (HP:0010057)2.55904237
19Myokymia (HP:0002411)2.55503261
20Chronic hepatic failure (HP:0100626)2.53343447
21Nephronophthisis (HP:0000090)2.53153504
22Abnormal number of incisors (HP:0011064)2.52924434
23Amyotrophic lateral sclerosis (HP:0007354)2.52381374
24Abnormality of midbrain morphology (HP:0002418)2.51510290
25Molar tooth sign on MRI (HP:0002419)2.51510290
26Supernumerary spleens (HP:0009799)2.49962011
27Pancreatic cysts (HP:0001737)2.48179485
28Broad thumb (HP:0011304)2.44156756
29Basal cell carcinoma (HP:0002671)2.43527655
30Progressive cerebellar ataxia (HP:0002073)2.43431301
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.40844074
32Absent/shortened dynein arms (HP:0200106)2.40844074
33Absent radius (HP:0003974)2.40548723
34Focal motor seizures (HP:0011153)2.37316389
35Stomatitis (HP:0010280)2.36818258
36Focal seizures (HP:0007359)2.36330032
37Volvulus (HP:0002580)2.36001728
38Vitreoretinal degeneration (HP:0000655)2.35845262
39Anencephaly (HP:0002323)2.34311453
40Abnormality of incisor morphology (HP:0011063)2.33980085
41Esophageal atresia (HP:0002032)2.32079117
42Facial hemangioma (HP:0000329)2.31337091
43Aplasia involving forearm bones (HP:0009822)2.30515904
44Absent forearm bone (HP:0003953)2.30515904
45Glioma (HP:0009733)2.30465685
46Inappropriate behavior (HP:0000719)2.27917264
47Impulsivity (HP:0100710)2.26669713
48Abnormal respiratory motile cilium physiology (HP:0012261)2.25095095
49Patellar aplasia (HP:0006443)2.22195971
50Gait imbalance (HP:0002141)2.21959122
51Abnormality of the ischium (HP:0003174)2.21532323
52Poor coordination (HP:0002370)2.20310980
53Congenital primary aphakia (HP:0007707)2.19960199
54Peritonitis (HP:0002586)2.17891100
55Annular pancreas (HP:0001734)2.17559712
56Abnormality of the phalanges of the 2nd finger (HP:0009541)2.17366128
57Medial flaring of the eyebrow (HP:0010747)2.16673616
58Chromsome breakage (HP:0040012)2.16027759
59Recurrent bacterial skin infections (HP:0005406)2.14722886
60Prominent nose (HP:0000448)2.14497567
61Urethral obstruction (HP:0000796)2.14421819
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.14240136
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14228388
64High anterior hairline (HP:0009890)2.13700489
65Broad phalanges of the hand (HP:0009768)2.10895263
66Abnormal respiratory epithelium morphology (HP:0012253)2.10570835
67Abnormal respiratory motile cilium morphology (HP:0005938)2.10570835
68Broad phalanx (HP:0006009)2.09536597
69Abnormality of the lower motor neuron (HP:0002366)2.07061853
70Optic neuritis (HP:0100653)2.06904138
71Retrobulbar optic neuritis (HP:0100654)2.06904138
72Broad long bones (HP:0005622)2.06894454
73Rhabdomyosarcoma (HP:0002859)2.05628065
74Aplasia/Hypoplasia of the patella (HP:0006498)2.05538861
75Short 4th metacarpal (HP:0010044)2.05462279
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05462279
77Breast hypoplasia (HP:0003187)2.05271549
78Optic nerve hypoplasia (HP:0000609)2.05004161
79Abnormality of the parietal bone (HP:0002696)2.04656288
80Supernumerary ribs (HP:0005815)2.03545534
81Rib fusion (HP:0000902)2.02801064
82Broad finger (HP:0001500)2.02793909
83Nephrogenic diabetes insipidus (HP:0009806)2.02508721
84Supernumerary bones of the axial skeleton (HP:0009144)2.01104351
85Aqueductal stenosis (HP:0002410)2.00866269
86Shawl scrotum (HP:0000049)2.00424888
87Abnormality of the renal medulla (HP:0100957)2.00074399
88Broad-based gait (HP:0002136)1.99365892
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.98916826
90Neoplasm of striated muscle (HP:0009728)1.98802437
91Abnormality of the incisor (HP:0000676)1.97812189
92Anophthalmia (HP:0000528)1.97475394
93Postaxial foot polydactyly (HP:0001830)1.97389011
94Atrophy/Degeneration involving motor neurons (HP:0007373)1.97146274
95Intestinal fistula (HP:0100819)1.96617118
96Truncal obesity (HP:0001956)1.96347993
97Febrile seizures (HP:0002373)1.95707553
98Ectopic kidney (HP:0000086)1.95130324
99Myositis (HP:0100614)1.94599112
100Orchitis (HP:0100796)1.93457280
101Rectovaginal fistula (HP:0000143)1.93201249
102Rectal fistula (HP:0100590)1.93201249
103Preaxial foot polydactyly (HP:0001841)1.92380572
104Hypochromic microcytic anemia (HP:0004840)1.92171707
105Selective tooth agenesis (HP:0001592)1.89760478
106Genetic anticipation (HP:0003743)1.88380657
107Sclerocornea (HP:0000647)1.88300568
108Proximal placement of thumb (HP:0009623)1.88264101
109Postaxial hand polydactyly (HP:0001162)1.86791579
110Urinary bladder sphincter dysfunction (HP:0002839)1.86775776
111Anal stenosis (HP:0002025)1.86721416
112Abnormality of chromosome segregation (HP:0002916)1.84793037
113Mutism (HP:0002300)1.83921441
114Hypoplastic iliac wings (HP:0002866)1.83239159
115Malignant gastrointestinal tract tumors (HP:0006749)1.82960954
116Gastrointestinal carcinoma (HP:0002672)1.82960954
117Absent thumb (HP:0009777)1.82671881
118Vaginal atresia (HP:0000148)1.80834550
119Ankyloglossia (HP:0010296)1.80364178
120Genital tract atresia (HP:0001827)1.79888675
121Absent septum pellucidum (HP:0001331)1.77881384
122Sparse scalp hair (HP:0002209)1.77761711
123Biliary tract neoplasm (HP:0100574)1.77758762
124Reticulocytopenia (HP:0001896)1.76773997
125Oligodactyly (HP:0012165)1.76055544
126Cystic liver disease (HP:0006706)1.75784351
127Increased nuchal translucency (HP:0010880)1.74504330
128Abnormality of binocular vision (HP:0011514)1.74242766
129Diplopia (HP:0000651)1.74242766
130Growth hormone deficiency (HP:0000824)1.74125968
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73454760
132Pointed chin (HP:0000307)1.73390568
133Shoulder girdle muscle weakness (HP:0003547)1.73313515
134Visual hallucinations (HP:0002367)1.73233315
135Abnormality of the aortic arch (HP:0012303)1.72996832
136Impaired smooth pursuit (HP:0007772)1.72958806
137Preaxial hand polydactyly (HP:0001177)1.72807557
138Attention deficit hyperactivity disorder (HP:0007018)1.72577770
139Abnormality of the septum pellucidum (HP:0007375)1.72427205
140Pelvic girdle muscle weakness (HP:0003749)1.72301396
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72014469
142Disinhibition (HP:0000734)1.71992467
143Spinal muscular atrophy (HP:0007269)1.71537399
144Deviation of the thumb (HP:0009603)1.69414533
145Absent frontal sinuses (HP:0002688)1.68934131
146Atonic seizures (HP:0010819)1.68460009
147Broad foot (HP:0001769)1.67955785
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66950153
149Holoprosencephaly (HP:0001360)1.66724940
150Carpal bone hypoplasia (HP:0001498)1.66390104
151Hip dysplasia (HP:0001385)1.65489100
152Urinary urgency (HP:0000012)1.64824955
153Oligodactyly (hands) (HP:0001180)1.64416517
154Recurrent abscess formation (HP:0002722)1.64264986
155Narrow forehead (HP:0000341)1.64149919
156Abnormality of the antihelix (HP:0009738)1.63837593
157Trigonocephaly (HP:0000243)1.63452906
158Mesomelia (HP:0003027)1.63214990
159Amaurosis fugax (HP:0100576)1.62229441
160Intellectual disability, moderate (HP:0002342)1.61868776
161Premature ovarian failure (HP:0008209)1.61793463
162Orthostatic hypotension (HP:0001278)1.61678306
163Papilledema (HP:0001085)1.61493536
164Aplasia/hypoplasia of the humerus (HP:0006507)1.61348420
165Narrow palate (HP:0000189)1.61044025
166Synostosis of carpal bones (HP:0005048)1.60918005
167Broad toe (HP:0001837)1.60722254
168Abnormal hair whorl (HP:0010721)1.60703574
169Cafe-au-lait spot (HP:0000957)1.60225756
170Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.59139392
171Drooling (HP:0002307)1.58964471
172Excessive salivation (HP:0003781)1.58964471
173Heterotopia (HP:0002282)1.58892487
174Horseshoe kidney (HP:0000085)1.58585410
175Large earlobe (HP:0009748)1.57866146
176Personality changes (HP:0000751)1.57444824
177Abnormality of abdominal situs (HP:0011620)1.56742550
178Abdominal situs inversus (HP:0003363)1.56742550
179Atresia of the external auditory canal (HP:0000413)1.56677360
180Abnormality of ocular smooth pursuit (HP:0000617)1.56365199
181Meckel diverticulum (HP:0002245)1.55816181
182Breast aplasia (HP:0100783)1.55021281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.12064732
2PNCK3.50439225
3CDK123.43792891
4WEE13.38565639
5CDC72.75588968
6TSSK62.69250521
7BUB12.50577008
8EPHA42.24004612
9MAP3K42.11841293
10MARK12.06000436
11TYRO32.05831936
12DYRK1B1.81226011
13NEK21.76363537
14ALK1.68015722
15NTRK21.66521344
16MARK21.63940497
17NTRK31.61994700
18RIPK41.59204311
19MKNK21.58574697
20GRK61.57014976
21NEK11.55245215
22CAMK1G1.53260444
23KSR21.52774140
24SGK21.49893022
25KSR11.49635883
26LATS21.48515912
27SRPK11.36999081
28TAOK11.33619402
29UHMK11.32976772
30EPHB21.32705662
31MKNK11.30423916
32BRD41.30322025
33SGK4941.28791624
34SGK2231.28791624
35EPHA21.27129631
36PLK31.25821189
37SIK21.23924805
38MINK11.22558878
39MARK31.21118056
40PLK11.17185921
41PLK41.16438788
42CHEK21.16100775
43PIK3CG1.16097345
44CAMK11.07842673
45WNK31.05326100
46CHEK11.05316432
47DDR21.04594972
48RAF11.03623225
49IRAK41.03224081
50BLK1.02907615
51CAMKK21.02655925
52RPS6KB21.02494161
53CDK41.00568046
54MAP2K30.98496600
55CSK0.98393480
56STK100.96360618
57MAP4K20.96265486
58FGR0.95394086
59TTK0.95247258
60CDK70.95203357
61MAP3K110.94626950
62SGK30.94531185
63STK110.92891687
64FES0.92838219
65CDK20.91682088
66AKT30.91191557
67WNK10.91186546
68DAPK10.90311226
69IRAK10.90198221
70EEF2K0.89530028
71MAP2K70.89401041
72ATR0.88772152
73BTK0.85814067
74BRSK10.84625105
75MAP3K130.84556154
76FRK0.84142805
77MAPK70.81926704
78MAPK130.81658754
79CAMK40.80965587
80RPS6KA60.79096590
81MELK0.78170300
82RPS6KC10.77123927
83RPS6KL10.77123927
84DYRK30.76931285
85HCK0.75990114
86IRAK20.75550396
87MAP3K100.75490153
88CAMK1D0.75272531
89YES10.74691522
90PTK2B0.74565106
91PAK30.74286502
92BCR0.74011205
93MAP3K60.73948912
94CSNK1D0.72479207
95PINK10.72197408
96TEC0.70650304
97AURKB0.69470819
98NLK0.69424320
99PKN10.68900192
100PAK60.68147345
101NEK90.67892805
102ACVR1B0.66811197
103ATM0.66042297
104MAP3K120.65975869
105CDK10.65949628
106BRSK20.65920688
107CCNB10.65871320
108PIM10.65822513
109MAP2K40.65462368
110MAPK150.64791441
111SGK10.64073107
112CDK60.64000215
113AURKA0.63820329
114MAP3K70.63639309
115KIT0.63250107
116CSNK1E0.61971638
117TLK10.60861124
118PDGFRB0.59166566
119MAPK100.58675836
120IKBKE0.58335134
121PRKD20.58014094
122TYK20.56743835
123CDK90.55934350
124GRK50.55513316
125MAP3K80.55501933
126SYK0.55165997
127DYRK1A0.54136637
128LYN0.54117257
129ARAF0.54053713
130SCYL20.53877753
131TAOK30.53365055
132NUAK10.52392216
133DYRK20.51994335
134PRKCH0.51009914
135TNIK0.50608584
136JAK20.50128285
137GSK3B0.49198240
138CDK50.48752367
139CAMKK10.47220088
140GRK70.46215137
141ERBB30.45839362
142TGFBR20.45761559
143PRKCG0.45449370
144MOS0.45212379
145MAPK140.44577330
146PLK20.44456946
147CDK180.43920544
148PRKCI0.43766808
149CDK190.43303791
150PIK3CA0.43030204
151FGFR10.42825095
152EIF2AK10.41628621
153MATK0.41314228
154CDK150.40784893
155AKT20.40611249
156CSNK2A20.40545497
157MAPK80.40283581
158CDK11A0.39335940
159STK380.38607320
160TGFBR10.37882934
161FGFR20.37097572
162CASK0.37031657

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59916087
2RNA transport_Homo sapiens_hsa030132.10466572
3Mismatch repair_Homo sapiens_hsa034302.04583330
4Spliceosome_Homo sapiens_hsa030401.90304024
5Osteoclast differentiation_Homo sapiens_hsa043801.79287610
6Oocyte meiosis_Homo sapiens_hsa041141.70979277
7Cell cycle_Homo sapiens_hsa041101.68719805
8mRNA surveillance pathway_Homo sapiens_hsa030151.68314072
9DNA replication_Homo sapiens_hsa030301.67119030
10Notch signaling pathway_Homo sapiens_hsa043301.64805371
11Long-term potentiation_Homo sapiens_hsa047201.57790579
12RNA polymerase_Homo sapiens_hsa030201.57245627
13Nicotine addiction_Homo sapiens_hsa050331.53162027
14Olfactory transduction_Homo sapiens_hsa047401.48185213
15Colorectal cancer_Homo sapiens_hsa052101.46780970
16Leishmaniasis_Homo sapiens_hsa051401.43674182
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42414549
18Malaria_Homo sapiens_hsa051441.42114806
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29367110
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24822264
21mTOR signaling pathway_Homo sapiens_hsa041501.20097662
22Nucleotide excision repair_Homo sapiens_hsa034201.16453192
23Base excision repair_Homo sapiens_hsa034101.13233475
24Dorso-ventral axis formation_Homo sapiens_hsa043201.12278911
25Tuberculosis_Homo sapiens_hsa051521.09736799
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09713284
27Amphetamine addiction_Homo sapiens_hsa050311.09029263
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08387543
29Dopaminergic synapse_Homo sapiens_hsa047281.07098199
30Synaptic vesicle cycle_Homo sapiens_hsa047211.03303448
31Prolactin signaling pathway_Homo sapiens_hsa049171.02962458
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02883958
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02848944
34Glutamatergic synapse_Homo sapiens_hsa047241.02521367
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.02147313
36cAMP signaling pathway_Homo sapiens_hsa040241.02052726
37ErbB signaling pathway_Homo sapiens_hsa040121.00619439
38Endometrial cancer_Homo sapiens_hsa052131.00076958
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99953888
40MicroRNAs in cancer_Homo sapiens_hsa052060.99697355
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98998684
42Epstein-Barr virus infection_Homo sapiens_hsa051690.98974462
43Hippo signaling pathway_Homo sapiens_hsa043900.98162469
44Glioma_Homo sapiens_hsa052140.97913889
45RNA degradation_Homo sapiens_hsa030180.97871208
46Non-small cell lung cancer_Homo sapiens_hsa052230.97823099
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97368436
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97255922
49Thyroid cancer_Homo sapiens_hsa052160.96963473
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96527682
51p53 signaling pathway_Homo sapiens_hsa041150.96482308
52Morphine addiction_Homo sapiens_hsa050320.95644170
53B cell receptor signaling pathway_Homo sapiens_hsa046620.94913425
54GnRH signaling pathway_Homo sapiens_hsa049120.94117746
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93663903
56Fanconi anemia pathway_Homo sapiens_hsa034600.93415482
57Basal transcription factors_Homo sapiens_hsa030220.92991922
58Gap junction_Homo sapiens_hsa045400.92579634
59Alcoholism_Homo sapiens_hsa050340.90645650
60Acute myeloid leukemia_Homo sapiens_hsa052210.90476173
61T cell receptor signaling pathway_Homo sapiens_hsa046600.89795137
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89660142
63TNF signaling pathway_Homo sapiens_hsa046680.89534800
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89400726
65VEGF signaling pathway_Homo sapiens_hsa043700.87960428
66Non-homologous end-joining_Homo sapiens_hsa034500.87948311
67Cocaine addiction_Homo sapiens_hsa050300.86368395
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.86175916
69Renal cell carcinoma_Homo sapiens_hsa052110.85280546
70Homologous recombination_Homo sapiens_hsa034400.84867365
71Estrogen signaling pathway_Homo sapiens_hsa049150.84446010
72Wnt signaling pathway_Homo sapiens_hsa043100.84393124
73Long-term depression_Homo sapiens_hsa047300.84240897
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83645726
75Circadian entrainment_Homo sapiens_hsa047130.83330758
76Adherens junction_Homo sapiens_hsa045200.83086985
77Basal cell carcinoma_Homo sapiens_hsa052170.82723141
78Oxytocin signaling pathway_Homo sapiens_hsa049210.82184725
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82105307
80Cholinergic synapse_Homo sapiens_hsa047250.81695392
81African trypanosomiasis_Homo sapiens_hsa051430.81688690
82Viral carcinogenesis_Homo sapiens_hsa052030.80153955
83Measles_Homo sapiens_hsa051620.80083027
84Ras signaling pathway_Homo sapiens_hsa040140.80061434
85Salivary secretion_Homo sapiens_hsa049700.78633427
86Choline metabolism in cancer_Homo sapiens_hsa052310.76694246
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76291392
88Influenza A_Homo sapiens_hsa051640.75673143
89Ribosome_Homo sapiens_hsa030100.75360671
90Renin secretion_Homo sapiens_hsa049240.74330286
91Melanoma_Homo sapiens_hsa052180.72719919
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72647210
93MAPK signaling pathway_Homo sapiens_hsa040100.72543547
94Melanogenesis_Homo sapiens_hsa049160.72203274
95Prostate cancer_Homo sapiens_hsa052150.72067153
96Hedgehog signaling pathway_Homo sapiens_hsa043400.71164382
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70812079
98Regulation of autophagy_Homo sapiens_hsa041400.70207651
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69880944
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69341409
101Taste transduction_Homo sapiens_hsa047420.69243860
102Phototransduction_Homo sapiens_hsa047440.68949830
103Allograft rejection_Homo sapiens_hsa053300.68711627
104Chronic myeloid leukemia_Homo sapiens_hsa052200.67484444
105Systemic lupus erythematosus_Homo sapiens_hsa053220.67330872
106Graft-versus-host disease_Homo sapiens_hsa053320.67253246
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.67163300
108HTLV-I infection_Homo sapiens_hsa051660.66935864
109Axon guidance_Homo sapiens_hsa043600.66685933
110GABAergic synapse_Homo sapiens_hsa047270.66491993
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66050152
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65945571
113Herpes simplex infection_Homo sapiens_hsa051680.65027758
114Amoebiasis_Homo sapiens_hsa051460.64349188
115Antigen processing and presentation_Homo sapiens_hsa046120.64331931
116Toxoplasmosis_Homo sapiens_hsa051450.64233094
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.63573784
118Platelet activation_Homo sapiens_hsa046110.63536607
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63051815
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.62853966
121Inositol phosphate metabolism_Homo sapiens_hsa005620.62011073
122Serotonergic synapse_Homo sapiens_hsa047260.61723914
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60867670
124FoxO signaling pathway_Homo sapiens_hsa040680.60665001
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60572941
126Calcium signaling pathway_Homo sapiens_hsa040200.59830798
127Gastric acid secretion_Homo sapiens_hsa049710.59429895
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59313878
129Hepatitis B_Homo sapiens_hsa051610.59105150
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58493340
131Pathways in cancer_Homo sapiens_hsa052000.58038414
132TGF-beta signaling pathway_Homo sapiens_hsa043500.57241647
133Chemokine signaling pathway_Homo sapiens_hsa040620.56621591
134Pancreatic cancer_Homo sapiens_hsa052120.55814800
135Primary immunodeficiency_Homo sapiens_hsa053400.55244947
136Type II diabetes mellitus_Homo sapiens_hsa049300.55086688
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55009153
138Rap1 signaling pathway_Homo sapiens_hsa040150.54971862

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