TLE6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)8.61458720
2regulation of acrosome reaction (GO:0060046)8.31768909
3piRNA metabolic process (GO:0034587)8.31135285
4regulation of hypersensitivity (GO:0002883)6.83801535
5multicellular organism reproduction (GO:0032504)6.78710888
6protein localization to kinetochore (GO:0034501)6.48522077
7DNA methylation involved in gamete generation (GO:0043046)6.41588069
8regulation of retinoic acid receptor signaling pathway (GO:0048385)5.91171540
9female gamete generation (GO:0007292)5.87418240
10mitotic chromosome condensation (GO:0007076)5.62022435
11mitotic metaphase plate congression (GO:0007080)5.57711787
12positive regulation of histone H3-K4 methylation (GO:0051571)5.49898199
13citrulline biosynthetic process (GO:0019240)5.49633565
14positive regulation of humoral immune response (GO:0002922)5.41959792
15regulation of calcium ion-dependent exocytosis (GO:0017158)5.37192837
16negative regulation of reproductive process (GO:2000242)5.19848129
17reproduction (GO:0000003)5.19433995
18oocyte development (GO:0048599)5.17910291
19protein localization to chromosome, centromeric region (GO:0071459)5.17726241
20regulation of phospholipid biosynthetic process (GO:0071071)4.93964548
21metaphase plate congression (GO:0051310)4.91641392
22regulation of meiosis (GO:0040020)4.88885523
23regulation of histone H3-K9 methylation (GO:0051570)4.85959788
24positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.77624216
25negative regulation of meiosis (GO:0045835)4.70913152
26regulation of steroid hormone secretion (GO:2000831)4.69126580
27regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.59089610
28immunoglobulin mediated immune response (GO:0016064)4.55459249
29protein kinase C signaling (GO:0070528)4.52521393
30citrulline metabolic process (GO:0000052)4.51869676
31attachment of spindle microtubules to kinetochore (GO:0008608)4.50237147
32negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.50146247
33meiotic cell cycle (GO:0051321)4.49198782
34protein K6-linked ubiquitination (GO:0085020)4.43044569
35positive regulation of reproductive process (GO:2000243)4.41810294
36oocyte maturation (GO:0001556)4.39737792
37base-excision repair, AP site formation (GO:0006285)4.39029906
38binding of sperm to zona pellucida (GO:0007339)4.27077152
39histone H2A ubiquitination (GO:0033522)4.23799444
40cell-cell recognition (GO:0009988)4.22329489
41retinal cone cell development (GO:0046549)4.21307072
42establishment of chromosome localization (GO:0051303)4.18252168
43histone H2A monoubiquitination (GO:0035518)4.14084012
44regulation of DNA methylation (GO:0044030)4.10353781
45protein localization to chromosome (GO:0034502)4.08698075
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.07379192
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.07379192
48positive regulation of mitotic sister chromatid separation (GO:1901970)4.07379192
49DNA methylation (GO:0006306)4.04973324
50DNA alkylation (GO:0006305)4.04973324
51negative regulation of meiotic cell cycle (GO:0051447)4.00754996
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.95123779
53regulation of exit from mitosis (GO:0007096)3.93273681
54spindle checkpoint (GO:0031577)3.91982432
55negative regulation of DNA-templated transcription, elongation (GO:0032785)3.91001221
56negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.91001221
57negative regulation of chromosome segregation (GO:0051985)3.89518544
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.88913334
59oogenesis (GO:0048477)3.86505115
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.86092080
61negative regulation of sister chromatid segregation (GO:0033046)3.86092080
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.86092080
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.86092080
64male meiosis (GO:0007140)3.85463027
65mitotic sister chromatid segregation (GO:0000070)3.83423919
66mitotic spindle assembly checkpoint (GO:0007094)3.81821917
67phosphatidylinositol dephosphorylation (GO:0046856)3.80885996
68gene silencing by RNA (GO:0031047)3.79308556
69regulation of meiotic cell cycle (GO:0051445)3.78312169
70B cell mediated immunity (GO:0019724)3.70555460
71spindle assembly checkpoint (GO:0071173)3.70286640
72regulation of chromatin binding (GO:0035561)3.69742352
73fertilization (GO:0009566)3.68857267
74negative regulation of histone methylation (GO:0031061)3.67167376
75mitotic spindle checkpoint (GO:0071174)3.65885141
76phospholipid dephosphorylation (GO:0046839)3.63750388
77meiotic chromosome segregation (GO:0045132)3.62373156
78single fertilization (GO:0007338)3.58359281
79regulation of histone H3-K4 methylation (GO:0051569)3.56472765
80CENP-A containing nucleosome assembly (GO:0034080)3.56085093
81negative regulation of nuclear division (GO:0051784)3.49346683
82regulation of sister chromatid cohesion (GO:0007063)3.48649527
83protein deneddylation (GO:0000338)3.47910316
84pyrimidine nucleotide catabolic process (GO:0006244)3.46513597
85regulation of spindle organization (GO:0090224)3.46235334
86regulation of chromosome segregation (GO:0051983)3.43720321
87regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38331464
88regulation of mitotic sister chromatid separation (GO:0010965)3.36471733
89regulation of mitotic sister chromatid segregation (GO:0033047)3.36471733
90regulation of sister chromatid segregation (GO:0033045)3.36471733
91maturation of 5.8S rRNA (GO:0000460)3.36089051
92chromatin remodeling at centromere (GO:0031055)3.35522440
93negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.34354290
94negative regulation of cell division (GO:0051782)3.33450259
95negative regulation of mitosis (GO:0045839)3.31124687
96type B pancreatic cell development (GO:0003323)3.29546657
97notochord development (GO:0030903)3.28867667
98male meiosis I (GO:0007141)3.26687395
99regulation of mitotic spindle organization (GO:0060236)3.25539720
100regulation of reproductive process (GO:2000241)3.25475823
101histone H3-K9 demethylation (GO:0033169)3.25419682
102endothelium development (GO:0003158)3.25217213
103ovarian follicle development (GO:0001541)3.24793980
104regulation of meiosis I (GO:0060631)3.23076686
105chromosome segregation (GO:0007059)3.22556819
106stress granule assembly (GO:0034063)3.22333675
107regulation of steroid hormone biosynthetic process (GO:0090030)3.22226323
108positive regulation of histone methylation (GO:0031062)3.21128479
109positive regulation of gastrulation (GO:2000543)3.20368911
110sperm-egg recognition (GO:0035036)3.19253830
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19235290
112histone exchange (GO:0043486)3.18597754
113DNA modification (GO:0006304)3.15848433
114glycine transport (GO:0015816)3.15589015
115DNA replication-independent nucleosome organization (GO:0034724)3.14265718
116DNA replication-independent nucleosome assembly (GO:0006336)3.14265718
117synaptonemal complex assembly (GO:0007130)3.13130137
118DNA methylation or demethylation (GO:0044728)3.11185302
119positive regulation of chromosome segregation (GO:0051984)3.10154258
120positive regulation of calcium ion import (GO:0090280)3.04660475
121positive regulation of Cdc42 GTPase activity (GO:0043089)3.03368359
122peptidyl-arginine modification (GO:0018195)3.03065265
123interkinetic nuclear migration (GO:0022027)3.02119458
124sister chromatid segregation (GO:0000819)3.01901329
125regulation of histone H3-K27 methylation (GO:0061085)3.01801863
126positive regulation of DNA-dependent DNA replication (GO:2000105)3.01534883
127DNA damage induced protein phosphorylation (GO:0006975)3.00962030
128regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.96189776
129meiosis I (GO:0007127)2.94103837
130histone lysine demethylation (GO:0070076)2.93949963
131positive regulation of hormone biosynthetic process (GO:0046886)2.91962418
132positive regulation of interleukin-4 production (GO:0032753)2.91498141
133histone H3-K4 trimethylation (GO:0080182)2.89803348
134synaptonemal complex organization (GO:0070193)2.85679605
135gene silencing (GO:0016458)2.83303976
136positive regulation of exocytosis (GO:0045921)2.81671890
137regulation of histone methylation (GO:0031060)2.81438563
138DNA replication-dependent nucleosome organization (GO:0034723)2.80670446
139DNA replication-dependent nucleosome assembly (GO:0006335)2.80670446
140histone demethylation (GO:0016577)2.78024884
141regulation of chromatin silencing (GO:0031935)2.76660142
142regulation of cell maturation (GO:1903429)2.76540205
143regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71158807
144negative regulation of cAMP-mediated signaling (GO:0043951)2.69589019
145DNA replication checkpoint (GO:0000076)2.68528282
146regulation of cell cycle G2/M phase transition (GO:1902749)2.67315966
147regulation of corticosteroid hormone secretion (GO:2000846)2.66210654
148meiotic cell cycle process (GO:1903046)2.65746198
149chromosome organization involved in meiosis (GO:0070192)2.60729336
150centriole replication (GO:0007099)2.59657353
151protein demethylation (GO:0006482)2.59261985
152protein dealkylation (GO:0008214)2.59261985
153histone H3-K4 methylation (GO:0051568)2.58974347
154positive regulation of uterine smooth muscle contraction (GO:0070474)2.52842616
155N-terminal protein amino acid acetylation (GO:0006474)2.51384347
156regulation of female gonad development (GO:2000194)12.5685947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.92227333
2E2F7_22180533_ChIP-Seq_HELA_Human5.69870407
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.19042592
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.58201659
5AR_21909140_ChIP-Seq_LNCAP_Human3.47278016
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.33297646
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73186638
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68471992
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66807594
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.59056114
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58643367
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57577853
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.51065016
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.23809594
15GABP_19822575_ChIP-Seq_HepG2_Human2.23236112
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.21710894
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.10445168
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10240451
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08970058
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08665309
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.99579544
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94974171
23* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93763127
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91740650
25MYC_18940864_ChIP-ChIP_HL60_Human1.91317990
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.91001693
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85852314
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84987462
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.84897528
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84587844
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81707409
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80380064
33CIITA_25753668_ChIP-Seq_RAJI_Human1.80090510
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72676410
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68785589
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65301232
37DCP1A_22483619_ChIP-Seq_HELA_Human1.65088275
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64408967
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59710169
40E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.57610621
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56023320
42EZH2_22144423_ChIP-Seq_EOC_Human1.54164017
43VDR_23849224_ChIP-Seq_CD4+_Human1.53822379
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49954192
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47695479
46FOXP3_21729870_ChIP-Seq_TREG_Human1.46891015
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46219978
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45829179
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45624838
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44878107
51* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.44712409
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42877354
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41459957
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40629720
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.36352277
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35711619
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35709093
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35136047
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34212988
60KDM5A_27292631_Chip-Seq_BREAST_Human1.33902782
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29627722
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.26414690
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24802882
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24583149
65SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23361514
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22859332
67RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20777454
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20515969
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19088344
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18911121
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18742116
72XRN2_22483619_ChIP-Seq_HELA_Human1.17986544
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15470421
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15244760
75* TTF2_22483619_ChIP-Seq_HELA_Human1.13546067
76GBX2_23144817_ChIP-Seq_PC3_Human1.12570656
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12383486
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10281554
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10184226
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10135821
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10127938
82* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08962444
83ESET_19884257_ChIP-Seq_ESCs_Mouse1.08044602
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07806927
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07015137
86ZNF274_21170338_ChIP-Seq_K562_Hela1.05557311
87MYC_22102868_ChIP-Seq_BL_Human1.04264872
88* NANOG_21062744_ChIP-ChIP_HESCs_Human1.03989178
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.03200994
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01413828
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00616948
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99273063
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97861137
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97441271
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96099794
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95954016
97ERG_20517297_ChIP-Seq_VCAP_Human0.95922070
98* TP63_19390658_ChIP-ChIP_HaCaT_Human0.95564758
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94721418
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91933977
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91748236
102EZH2_27304074_Chip-Seq_ESCs_Mouse0.90775270
103GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90036326
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89554983
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88908343
106SPI1_26923725_Chip-Seq_HPCs_Mouse0.88902405
107YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88444834
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88283235
109GATA3_21867929_ChIP-Seq_TH1_Mouse0.87552622
110E2F1_17053090_ChIP-ChIP_MCF-7_Human0.85901646
111IRF1_19129219_ChIP-ChIP_H3396_Human0.84862881
112* NANOG_20526341_ChIP-Seq_ESCs_Human0.84635679
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84360739
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83785079
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83287860
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83260187
117RNF2_27304074_Chip-Seq_NSC_Mouse0.83214116
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82941677
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82941677
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82941677
121TFEB_21752829_ChIP-Seq_HELA_Human0.82071242
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81844669
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81478004
124REST_21632747_ChIP-Seq_MESCs_Mouse0.80508065
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80468810
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78951472
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78690817
128TP53_22573176_ChIP-Seq_HFKS_Human0.76869146
129LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75995693
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74077981
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73213106
132BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72359787
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.70009542
134TCF4_23295773_ChIP-Seq_U87_Human0.68662684
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.67518191
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67407853
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.67407853
138* OCT4_19829295_ChIP-Seq_ESCs_Human0.67359626
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.65005472
140* FOXH1_21741376_ChIP-Seq_EPCs_Human0.63076298
141* KLF4_19829295_ChIP-Seq_ESCs_Human0.62625754
142LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62488192
143AR_25329375_ChIP-Seq_VCAP_Human0.62400874
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.62257825
145RUNX2_22187159_ChIP-Seq_PCA_Human0.60469064
146P68_20966046_ChIP-Seq_HELA_Human0.60351768
147NCOR_22424771_ChIP-Seq_293T_Human0.59374207
148* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.58477796
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.57957405
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.57775530
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.57229634
152TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56652090
153POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.54944565
154PHF8_20622854_ChIP-Seq_HELA_Human0.54376310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.73269130
2MP0003693_abnormal_embryo_hatching4.39405851
3MP0008877_abnormal_DNA_methylation4.37909281
4MP0010094_abnormal_chromosome_stability4.14886846
5MP0005451_abnormal_body_composition3.74704453
6MP0005394_taste/olfaction_phenotype3.71056608
7MP0005499_abnormal_olfactory_system3.71056608
8MP0008789_abnormal_olfactory_epithelium3.61231687
9MP0003077_abnormal_cell_cycle3.18825275
10MP0001119_abnormal_female_reproductive3.17018787
11MP0003699_abnormal_female_reproductive3.12197131
12MP0004957_abnormal_blastocyst_morpholog3.08186421
13MP0003646_muscle_fatigue3.06022446
14MP0003111_abnormal_nucleus_morphology3.02722680
15MP0001929_abnormal_gametogenesis2.88685055
16MP0005395_other_phenotype2.68884589
17MP0000653_abnormal_sex_gland2.52399298
18MP0005220_abnormal_exocrine_pancreas2.49859482
19MP0005645_abnormal_hypothalamus_physiol2.45794398
20MP0002210_abnormal_sex_determination2.29193705
21MP0002139_abnormal_hepatobiliary_system2.14711391
22MP0002234_abnormal_pharynx_morphology2.13667402
23MP0003121_genomic_imprinting2.04824545
24MP0000465_gastrointestinal_hemorrhage1.95526824
25MP0001666_abnormal_nutrient_absorption1.91014537
26MP0004264_abnormal_extraembryonic_tissu1.89263341
27MP0001919_abnormal_reproductive_system1.88990839
28MP0003890_abnormal_embryonic-extraembry1.88955504
29MP0003123_paternal_imprinting1.84848439
30MP0000631_abnormal_neuroendocrine_gland1.82767468
31MP0005083_abnormal_biliary_tract1.78172325
32MP0008932_abnormal_embryonic_tissue1.75525676
33MP0002295_abnormal_pulmonary_circulatio1.73747237
34MP0008007_abnormal_cellular_replicative1.72448462
35MP0010234_abnormal_vibrissa_follicle1.72251862
36MP0002161_abnormal_fertility/fecundity1.70692673
37MP0006292_abnormal_olfactory_placode1.68474709
38MP0003880_abnormal_central_pattern1.61634878
39MP0003879_abnormal_hair_cell1.60816589
40MP0008058_abnormal_DNA_repair1.59385384
41MP0001984_abnormal_olfaction1.59215400
42MP0002653_abnormal_ependyma_morphology1.58978984
43MP0002138_abnormal_hepatobiliary_system1.58517544
44MP0001145_abnormal_male_reproductive1.57758127
45MP0010030_abnormal_orbit_morphology1.56109703
46MP0005389_reproductive_system_phenotype1.55556024
47MP0000490_abnormal_crypts_of1.55500775
48MP0000566_synostosis1.54583866
49MP0003315_abnormal_perineum_morphology1.47250607
50MP0005365_abnormal_bile_salt1.46111571
51MP0006072_abnormal_retinal_apoptosis1.42805634
52MP0006276_abnormal_autonomic_nervous1.42431606
53MP0001529_abnormal_vocalization1.39781425
54MP0005646_abnormal_pituitary_gland1.39765816
55MP0000350_abnormal_cell_proliferation1.39162172
56MP0001915_intracranial_hemorrhage1.38370050
57MP0003868_abnormal_feces_composition1.37961723
58MP0010307_abnormal_tumor_latency1.30277781
59MP0002019_abnormal_tumor_incidence1.29388762
60MP0002160_abnormal_reproductive_system1.29255520
61MP0008995_early_reproductive_senescence1.27569640
62MP0001730_embryonic_growth_arrest1.26883899
63MP0009384_cardiac_valve_regurgitation1.26489497
64MP0004270_analgesia1.26394275
65MP0005410_abnormal_fertilization1.25074508
66MP0005408_hypopigmentation1.23095705
67MP0005084_abnormal_gallbladder_morpholo1.20742803
68MP0002932_abnormal_joint_morphology1.18763017
69MP0009840_abnormal_foam_cell1.18671816
70MP0000579_abnormal_nail_morphology1.18014816
71MP0001905_abnormal_dopamine_level1.16993347
72MP0003950_abnormal_plasma_membrane1.14824639
73MP0005380_embryogenesis_phenotype1.13629221
74MP0001672_abnormal_embryogenesis/_devel1.13629221
75MP0003763_abnormal_thymus_physiology1.12707286
76MP0004808_abnormal_hematopoietic_stem1.10811376
77MP0002102_abnormal_ear_morphology1.10220899
78MP0002085_abnormal_embryonic_tissue1.07542912
79MP0002233_abnormal_nose_morphology1.06522220
80MP0001697_abnormal_embryo_size1.01463057
81MP0002396_abnormal_hematopoietic_system1.00961427
82MP0005360_urolithiasis0.98885162
83MP0010368_abnormal_lymphatic_system0.98507834
84MP0003136_yellow_coat_color0.97931281
85MP0002249_abnormal_larynx_morphology0.97817573
86MP0005551_abnormal_eye_electrophysiolog0.96499040
87MP0003937_abnormal_limbs/digits/tail_de0.94154478
88MP0000639_abnormal_adrenal_gland0.91603512
89MP0000313_abnormal_cell_death0.91470084
90MP0005647_abnormal_sex_gland0.91431567
91MP0001293_anophthalmia0.87687181
92MP0003787_abnormal_imprinting0.87299442
93MP0008057_abnormal_DNA_replication0.86873808
94MP0003122_maternal_imprinting0.86337910
95MP0000427_abnormal_hair_cycle0.86276925
96MP0008260_abnormal_autophagy0.85991067
97MP0002084_abnormal_developmental_patter0.85912617
98MP0000049_abnormal_middle_ear0.85705760
99MP0000678_abnormal_parathyroid_gland0.84460887
100MP0002272_abnormal_nervous_system0.83373217
101MP0003786_premature_aging0.82268719
102MP0002080_prenatal_lethality0.82142207
103MP0001664_abnormal_digestion0.81704365
104MP0002693_abnormal_pancreas_physiology0.80827217
105MP0004142_abnormal_muscle_tone0.80671488
106MP0003183_abnormal_peptide_metabolism0.79370844
107MP0002909_abnormal_adrenal_gland0.78831145
108MP0003705_abnormal_hypodermis_morpholog0.78396913
109MP0003119_abnormal_digestive_system0.77381229
110MP0002735_abnormal_chemical_nociception0.76996499
111MP0003698_abnormal_male_reproductive0.76568479
112MP0003806_abnormal_nucleotide_metabolis0.76050988
113MP0005621_abnormal_cell_physiology0.76004472
114MP0002163_abnormal_gland_morphology0.75937170
115MP0002269_muscular_atrophy0.75082725
116MP0005023_abnormal_wound_healing0.75051858
117MP0002928_abnormal_bile_duct0.74916804
118MP0002734_abnormal_mechanical_nocicepti0.72850556
119MP0010386_abnormal_urinary_bladder0.72304551
120MP0005423_abnormal_somatic_nervous0.71724708
121MP0010678_abnormal_skin_adnexa0.71060380
122MP0001545_abnormal_hematopoietic_system0.70644908
123MP0005397_hematopoietic_system_phenotyp0.70644908
124MP0005384_cellular_phenotype0.69547409
125MP0001324_abnormal_eye_pigmentation0.69484270
126MP0002751_abnormal_autonomic_nervous0.69210104
127MP0002876_abnormal_thyroid_physiology0.67621097
128MP0002877_abnormal_melanocyte_morpholog0.67426236
129MP0001944_abnormal_pancreas_morphology0.67117758
130MP0002177_abnormal_outer_ear0.66581377
131MP0005379_endocrine/exocrine_gland_phen0.65777673
132MP0000778_abnormal_nervous_system0.65034979
133MP0003984_embryonic_growth_retardation0.64404613
134MP0002229_neurodegeneration0.62673445
135MP0001485_abnormal_pinna_reflex0.62588452
136MP0000003_abnormal_adipose_tissue0.62345518
137MP0003656_abnormal_erythrocyte_physiolo0.61570027
138MP0005197_abnormal_uvea_morphology0.60821177
139MP0001502_abnormal_circadian_rhythm0.60734977
140MP0006054_spinal_hemorrhage0.60156384
141MP0000762_abnormal_tongue_morphology0.60040624
142MP0005187_abnormal_penis_morphology0.59936723
143MP0002822_catalepsy0.59877156
144MP0000026_abnormal_inner_ear0.59579656
145MP0002088_abnormal_embryonic_growth/wei0.59450758
146MP0004924_abnormal_behavior0.59117195
147MP0005386_behavior/neurological_phenoty0.59117195
148MP0000613_abnormal_salivary_gland0.59094165
149MP0003861_abnormal_nervous_system0.58974764
150MP0003329_amyloid_beta_deposits0.58715965
151MP0000015_abnormal_ear_pigmentation0.58508135
152MP0002089_abnormal_postnatal_growth/wei0.58041633
153MP0003959_abnormal_lean_body0.57889955
154MP0002557_abnormal_social/conspecific_i0.56942960
155MP0004782_abnormal_surfactant_physiolog0.55336337
156MP0001986_abnormal_taste_sensitivity0.54669983
157MP0003943_abnormal_hepatobiliary_system0.54091670
158MP0003942_abnormal_urinary_system0.51315772
159MP0002933_joint_inflammation0.50338235
160MP0004145_abnormal_muscle_electrophysio0.48832714
161MP0003453_abnormal_keratinocyte_physiol0.47408613
162MP0005257_abnormal_intraocular_pressure0.46803610
163MP0000462_abnormal_digestive_system0.44325186
164MP0006036_abnormal_mitochondrial_physio0.44237768

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)7.23355405
2Male infertility (HP:0003251)5.67413811
3Anterior segment dysgenesis (HP:0007700)5.35246849
4Deep venous thrombosis (HP:0002625)4.80952327
5Secondary amenorrhea (HP:0000869)4.61797121
6Birth length less than 3rd percentile (HP:0003561)4.58818619
7Infertility (HP:0000789)4.47519785
8Rhabdomyosarcoma (HP:0002859)4.34634822
9Chromsome breakage (HP:0040012)4.31879400
10Hypergonadotropic hypogonadism (HP:0000815)4.14336072
11Cortical dysplasia (HP:0002539)4.10397022
12Carpal bone hypoplasia (HP:0001498)3.92607388
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.92593490
14Aplasia/Hypoplasia of the macula (HP:0008059)3.71140349
15Abdominal situs inversus (HP:0003363)3.65843673
16Abnormality of abdominal situs (HP:0011620)3.65843673
17Aplastic anemia (HP:0001915)3.64791130
18Breast hypoplasia (HP:0003187)3.50553943
19Hypokinesia (HP:0002375)3.44709638
20Aplasia/Hypoplasia affecting the retina (HP:0008061)3.43781792
21Oligodactyly (hands) (HP:0001180)3.38019398
22Osteomalacia (HP:0002749)3.31691237
23Pulmonary fibrosis (HP:0002206)3.29616692
24Aplasia/Hypoplasia of the sternum (HP:0006714)3.24317732
25Flat capital femoral epiphysis (HP:0003370)3.20674939
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.20218715
27Neoplasm of striated muscle (HP:0009728)3.08960847
28Patellar aplasia (HP:0006443)3.08514590
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.94401691
30Abnormal lung lobation (HP:0002101)2.91147697
31Hypophosphatemic rickets (HP:0004912)2.90846828
32Apathy (HP:0000741)2.90666944
33Enlarged penis (HP:0000040)2.83642814
34Facial hemangioma (HP:0000329)2.80581343
35Diminished motivation (HP:0000745)2.80068749
36Type 2 muscle fiber atrophy (HP:0003554)2.79974171
37Myelodysplasia (HP:0002863)2.79203152
38Lip pit (HP:0100267)2.76863727
39Abnormality of chromosome segregation (HP:0002916)2.75863541
40Aplasia/Hypoplasia of the patella (HP:0006498)2.75159445
41Cholecystitis (HP:0001082)2.71603785
42Abnormal gallbladder physiology (HP:0012438)2.71603785
43Myokymia (HP:0002411)2.68405216
44Septo-optic dysplasia (HP:0100842)2.65949332
45Duodenal stenosis (HP:0100867)2.65203784
46Small intestinal stenosis (HP:0012848)2.65203784
47Wrist flexion contracture (HP:0001239)2.65136665
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.64796996
49Hypoplasia of the fovea (HP:0007750)2.64796996
50Impulsivity (HP:0100710)2.60679497
51Oligodactyly (HP:0012165)2.58727502
52Abnormality of the labia minora (HP:0012880)2.58626656
53Muscle fiber atrophy (HP:0100295)2.58104841
54Shawl scrotum (HP:0000049)2.56571008
55Colon cancer (HP:0003003)2.55418116
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52049758
57Abnormality of alanine metabolism (HP:0010916)2.52049758
58Hyperalaninemia (HP:0003348)2.52049758
59Nephroblastoma (Wilms tumor) (HP:0002667)2.49908884
60Supernumerary spleens (HP:0009799)2.49856829
61Combined immunodeficiency (HP:0005387)2.45911580
62Abnormality of the fovea (HP:0000493)2.45364097
63Embryonal renal neoplasm (HP:0011794)2.43433258
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.40585877
65Cerebral hypomyelination (HP:0006808)2.39366997
66Spondylolisthesis (HP:0003302)2.37445580
67Urethral obstruction (HP:0000796)2.36749289
68Azoospermia (HP:0000027)2.36709513
69Overlapping toe (HP:0001845)2.35833631
70Sloping forehead (HP:0000340)2.34748658
71Ankle contracture (HP:0006466)2.33192897
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29886074
73Papillary thyroid carcinoma (HP:0002895)2.29491594
74Slender long bone (HP:0003100)2.27191101
75Oral leukoplakia (HP:0002745)2.27168530
76Medulloblastoma (HP:0002885)2.24406904
77Abnormality of chromosome stability (HP:0003220)2.21900023
78Acute myeloid leukemia (HP:0004808)2.18249388
79Atelectasis (HP:0100750)2.16636414
80Medial flaring of the eyebrow (HP:0010747)2.15856751
81Abnormality of the anterior chamber (HP:0000593)2.14727768
82Adrenal hypoplasia (HP:0000835)2.14600899
83Thyroid carcinoma (HP:0002890)2.14147601
84Chronic bronchitis (HP:0004469)2.14049040
85Neoplasm of the oral cavity (HP:0100649)2.13711376
86Abnormality of the duodenum (HP:0002246)2.12890313
87Tubulointerstitial nephritis (HP:0001970)2.12489871
88Nonprogressive disorder (HP:0003680)2.11820126
89Abnormality of the proximal phalanges of the hand (HP:0009834)2.09989131
90Abnormality of DNA repair (HP:0003254)2.09930096
91Neoplasm of the colon (HP:0100273)2.09768676
92Aplasia/Hypoplasia of the breasts (HP:0010311)2.07971053
93Insulin-resistant diabetes mellitus (HP:0000831)2.07598323
94Loss of speech (HP:0002371)2.06401267
95CNS hypomyelination (HP:0003429)2.04650065
96Breast aplasia (HP:0100783)2.04564991
97Abnormality of the epiphysis of the femoral head (HP:0010574)2.03822070
98Increased circulating renin level (HP:0000848)2.03555672
99Aplasia/Hypoplasia involving the musculature (HP:0001460)2.01855224
100Progressive sensorineural hearing impairment (HP:0000408)2.01480199
101Abnormality of the femoral head (HP:0003368)2.00521802
102Proximal tubulopathy (HP:0000114)1.99790981
103Congenital sensorineural hearing impairment (HP:0008527)1.94449948
104Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93452215
105Abnormality of the labia (HP:0000058)1.93175276
106Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.92289663
107Abnormality of the preputium (HP:0100587)1.91964136
108Fatigue (HP:0012378)1.91629164
109Increased nuchal translucency (HP:0010880)1.91159896
110Abnormality of the ileum (HP:0001549)1.90776321
111Capillary hemangiomas (HP:0005306)1.90697009
112Truncal obesity (HP:0001956)1.87976334
113Diminished movement (HP:0002374)1.86400946
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.85941014
115Aplasia of the musculature (HP:0100854)1.85429613
116Congenital malformation of the right heart (HP:0011723)1.85241662
117Double outlet right ventricle (HP:0001719)1.85241662
118Short tibia (HP:0005736)1.84960942
119Gait imbalance (HP:0002141)1.84880088
120Supranuclear gaze palsy (HP:0000605)1.84875320
121Meckel diverticulum (HP:0002245)1.84459058
122Diastasis recti (HP:0001540)1.83709367
123Primary amenorrhea (HP:0000786)1.83432937
124Polycystic ovaries (HP:0000147)1.83319143
125Thrombocytosis (HP:0001894)1.81384962
126Congenital primary aphakia (HP:0007707)1.81314754
127Cafe-au-lait spot (HP:0000957)1.80600387
128Steatorrhea (HP:0002570)1.80191184
129Microretrognathia (HP:0000308)1.79979467
130Malnutrition (HP:0004395)1.78989981
131Dysmetric saccades (HP:0000641)1.78723607
132Abnormality of femoral epiphyses (HP:0006499)1.78642621
133Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78642621
134Absent septum pellucidum (HP:0001331)1.78175802
135Nephrogenic diabetes insipidus (HP:0009806)1.77745975
136Absent thumb (HP:0009777)1.77275548
137Abnormality of cochlea (HP:0000375)1.75133940
138Abnormality of the line of Schwalbe (HP:0008048)1.74928911
139Abnormality of calcium-phosphate metabolism (HP:0100530)1.74856434
140Decreased circulating renin level (HP:0003351)1.73349884
141Median cleft lip (HP:0000161)1.73249006
142Methylmalonic acidemia (HP:0002912)1.73040648
143Hypoplasia of the pons (HP:0012110)1.72596290
144Sandal gap (HP:0001852)1.72010309
145Arterial tortuosity (HP:0005116)1.71985787
146Gonadotropin excess (HP:0000837)1.71847377
147Posterior embryotoxon (HP:0000627)1.70599828
148Bone marrow hypocellularity (HP:0005528)1.69777772
149Limb hypertonia (HP:0002509)1.69435605
150Progressive hearing impairment (HP:0001730)1.69238663
151Protrusio acetabuli (HP:0003179)1.69040671
152Abnormal spermatogenesis (HP:0008669)1.68963348
153Dysdiadochokinesis (HP:0002075)1.68928957
154Leiomyosarcoma (HP:0100243)1.68894720
155Uterine leiomyosarcoma (HP:0002891)1.68894720
156Abnormality of the pons (HP:0007361)1.68730433
157Horseshoe kidney (HP:0000085)1.68301035
158Hand muscle atrophy (HP:0009130)1.65814542
159Skin pits (HP:0100276)1.64760406
160Poikiloderma (HP:0001029)1.64521243
161Bundle branch block (HP:0011710)1.64304386
162Abnormality of midbrain morphology (HP:0002418)1.64194225
163Molar tooth sign on MRI (HP:0002419)1.64194225
164Lower limb hyperreflexia (HP:0002395)1.63500944
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.61862222
166Chronic hepatic failure (HP:0100626)1.61700963
167Hypoglycemic coma (HP:0001325)1.61436435
168Amblyopia (HP:0000646)1.59718448
169Hyperactive renin-angiotensin system (HP:0000841)1.57058849
170Maternal diabetes (HP:0009800)1.56472676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.00863326
2TTK4.76620883
3MAP3K64.39402740
4TAOK34.14043825
5MOS4.07529336
6BMPR23.67382899
7PLK43.62872237
8EEF2K3.55340678
9TRIM283.43394473
10STK103.19490102
11BRAF3.18591863
12NEK62.67421163
13MUSK2.42662968
14MAPKAPK32.14032128
15CDC72.12526474
16CDK82.07708020
17MET2.01830833
18CAMK1D1.85540076
19CHEK21.85490537
20BUB11.84793138
21BCKDK1.82129384
22STK38L1.81222172
23PLK11.80099432
24LATS11.77931429
25KSR21.67599039
26NTRK21.65219652
27TNIK1.64992746
28ERBB41.62530154
29MAPKAPK51.56984095
30MAP3K81.55442312
31LATS21.51578770
32ACVR1B1.47681444
33NEK21.44250309
34MELK1.43387731
35WNK31.37795713
36MAP3K131.37643374
37RPS6KB21.31602591
38MAP3K91.28529717
39ARAF1.24341795
40KSR11.23003625
41NME11.17950240
42CAMK1G1.15339377
43NLK1.13326095
44PTK21.12833016
45RAF11.11924790
46STK31.09618829
47AURKB1.09280052
48TAOK11.08440513
49ZAK1.07846346
50NTRK31.06977538
51STK161.04986261
52AURKA1.04719452
53INSRR1.01170500
54EIF2AK11.00917178
55LRRK21.00470566
56PRKD30.98801589
57CDK90.97914908
58KIT0.95737590
59CDK70.92897296
60DYRK20.91755656
61BRSK20.91652999
62MST40.85601483
63MAP4K20.80449827
64CSNK1D0.78157099
65AKT20.76954652
66MARK10.72953046
67STK240.71942854
68EPHA30.69650845
69MAPK130.69362027
70CSNK1E0.68624339
71WNK40.65199562
72RET0.64910838
73PRKCZ0.64419674
74TRPM70.64355473
75WEE10.63206974
76CDK50.63043903
77ICK0.62700541
78CSNK1G10.62447544
79PASK0.60667207
80PKN10.59094496
81MAP2K20.56640184
82PRKD20.56379383
83CDK40.55867088
84TLK10.55089067
85PINK10.53904326
86CAMK40.53612001
87PRKAA20.53353702
88BCR0.52999401
89ATR0.52793206
90FRK0.52381085
91BRD40.51451918
92ATM0.51171162
93CHEK10.49995782
94WNK10.49638685
95RPS6KA40.48077821
96GSK3B0.47984970
97PLK20.47448673
98CSNK1G30.47147285
99MAPK110.46577146
100MAP3K40.45333855
101ERN10.44935838
102PRKAA10.43384818
103MAP2K70.42896456
104PLK30.42256147
105MAPK100.41648938
106NEK10.41237532
107VRK10.40122445
108TGFBR10.39237453
109STK390.38856678
110DYRK30.37949718
111MATK0.37880989
112CDK10.37079372
113TESK10.36198369
114TESK20.35964275
115CDK30.35833757
116MAP3K20.35467205
117CHUK0.35387729
118MAPK140.34801756
119SRPK10.34677761
120FLT30.33319201
121CDK20.32772283
122PKN20.32057506
123NME20.31971217
124PAK10.30196203
125PIM10.30062962
126MARK20.28565159
127NUAK10.28353815
128SCYL20.28110377
129BRSK10.26209855
130MAPK10.23009511
131EIF2AK30.22504471
132MAP3K50.22360653
133MTOR0.21494199
134BTK0.21035113
135PRKCI0.21001442
136ABL10.20316279
137AKT10.19787453
138CDK190.19417264
139HIPK20.18788890
140CSNK1A1L0.17642163
141CSNK1G20.16866546
142MAP3K10.16646427
143TEC0.16414443

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.61453947
2Ovarian steroidogenesis_Homo sapiens_hsa049133.57613798
3RNA degradation_Homo sapiens_hsa030183.13390914
4Homologous recombination_Homo sapiens_hsa034403.10389972
5Basal transcription factors_Homo sapiens_hsa030223.05516840
6Base excision repair_Homo sapiens_hsa034102.70959611
7DNA replication_Homo sapiens_hsa030302.70217429
8Mismatch repair_Homo sapiens_hsa034302.68290858
9RNA polymerase_Homo sapiens_hsa030202.59721944
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57017994
11Fanconi anemia pathway_Homo sapiens_hsa034602.44863850
12Non-homologous end-joining_Homo sapiens_hsa034502.38389367
13Folate biosynthesis_Homo sapiens_hsa007902.27211838
14Vitamin B6 metabolism_Homo sapiens_hsa007502.23828399
15RNA transport_Homo sapiens_hsa030132.22428899
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.17919277
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.09706290
18Pancreatic secretion_Homo sapiens_hsa049722.07520626
19Linoleic acid metabolism_Homo sapiens_hsa005912.06926124
20Protein export_Homo sapiens_hsa030602.00545921
21Nucleotide excision repair_Homo sapiens_hsa034201.99641470
22Circadian rhythm_Homo sapiens_hsa047101.91203636
23Oocyte meiosis_Homo sapiens_hsa041141.76200580
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.75798121
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.71410990
26Gap junction_Homo sapiens_hsa045401.60335001
27Caffeine metabolism_Homo sapiens_hsa002321.59264879
28p53 signaling pathway_Homo sapiens_hsa041151.56698319
29Other glycan degradation_Homo sapiens_hsa005111.54864540
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.54361832
31Pyrimidine metabolism_Homo sapiens_hsa002401.50136999
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45985729
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42324615
34Ether lipid metabolism_Homo sapiens_hsa005651.37671598
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37337983
36Pancreatic cancer_Homo sapiens_hsa052121.34881598
37Arginine biosynthesis_Homo sapiens_hsa002201.31283763
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30279501
39ABC transporters_Homo sapiens_hsa020101.25145513
40Fatty acid elongation_Homo sapiens_hsa000621.23863706
41Protein digestion and absorption_Homo sapiens_hsa049741.23534902
42Lysine degradation_Homo sapiens_hsa003101.22854772
43mRNA surveillance pathway_Homo sapiens_hsa030151.20947712
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15053077
45Purine metabolism_Homo sapiens_hsa002301.13356262
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12150434
47Huntingtons disease_Homo sapiens_hsa050161.08288749
48Phototransduction_Homo sapiens_hsa047441.07133894
49Synaptic vesicle cycle_Homo sapiens_hsa047211.05256522
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04401560
51Regulation of autophagy_Homo sapiens_hsa041401.01609166
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01437883
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00655163
54GABAergic synapse_Homo sapiens_hsa047270.99810487
55Sulfur relay system_Homo sapiens_hsa041220.99102828
56MicroRNAs in cancer_Homo sapiens_hsa052060.98641845
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97221234
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95990487
59Thyroid cancer_Homo sapiens_hsa052160.92514825
60Sulfur metabolism_Homo sapiens_hsa009200.91956064
61Arachidonic acid metabolism_Homo sapiens_hsa005900.90208375
62Fat digestion and absorption_Homo sapiens_hsa049750.89175347
63TGF-beta signaling pathway_Homo sapiens_hsa043500.86926246
64Prolactin signaling pathway_Homo sapiens_hsa049170.82513034
65One carbon pool by folate_Homo sapiens_hsa006700.81134616
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79583565
67Cocaine addiction_Homo sapiens_hsa050300.77817251
68Nicotine addiction_Homo sapiens_hsa050330.75886577
69Spliceosome_Homo sapiens_hsa030400.75326477
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75277112
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75269022
72Notch signaling pathway_Homo sapiens_hsa043300.74894809
73Colorectal cancer_Homo sapiens_hsa052100.74479890
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73093866
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69220842
76Alcoholism_Homo sapiens_hsa050340.68657040
77Glycerolipid metabolism_Homo sapiens_hsa005610.68265761
78Parkinsons disease_Homo sapiens_hsa050120.66484249
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.65894569
80Arginine and proline metabolism_Homo sapiens_hsa003300.65192213
81Oxidative phosphorylation_Homo sapiens_hsa001900.64846288
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.63546417
83Biosynthesis of amino acids_Homo sapiens_hsa012300.63299997
84Selenocompound metabolism_Homo sapiens_hsa004500.61962487
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56485234
86Vibrio cholerae infection_Homo sapiens_hsa051100.55646094
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55645242
88Butanoate metabolism_Homo sapiens_hsa006500.55512565
89Olfactory transduction_Homo sapiens_hsa047400.55070828
90GnRH signaling pathway_Homo sapiens_hsa049120.54728630
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53858284
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53663536
93Collecting duct acid secretion_Homo sapiens_hsa049660.53351890
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51457454
95Proteasome_Homo sapiens_hsa030500.49738002
96N-Glycan biosynthesis_Homo sapiens_hsa005100.46858432
97HTLV-I infection_Homo sapiens_hsa051660.46120992
98Adherens junction_Homo sapiens_hsa045200.45102264
99Insulin secretion_Homo sapiens_hsa049110.44485551
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44143983
101Bile secretion_Homo sapiens_hsa049760.43867289
102Herpes simplex infection_Homo sapiens_hsa051680.41596264
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41522042
104Bladder cancer_Homo sapiens_hsa052190.39746176
105Choline metabolism in cancer_Homo sapiens_hsa052310.39277971
106Epstein-Barr virus infection_Homo sapiens_hsa051690.38859313
107Pyruvate metabolism_Homo sapiens_hsa006200.38798262
108mTOR signaling pathway_Homo sapiens_hsa041500.38330971
109Carbon metabolism_Homo sapiens_hsa012000.37303774
110Phenylalanine metabolism_Homo sapiens_hsa003600.36820648
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36803057
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36488652
113Steroid biosynthesis_Homo sapiens_hsa001000.36442066
114Taste transduction_Homo sapiens_hsa047420.36078363
115Morphine addiction_Homo sapiens_hsa050320.35256509
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34057405
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.32989816
118FoxO signaling pathway_Homo sapiens_hsa040680.32282369
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31924433
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31653067
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31649222
122Wnt signaling pathway_Homo sapiens_hsa043100.31539012
123Small cell lung cancer_Homo sapiens_hsa052220.30998007
124Dorso-ventral axis formation_Homo sapiens_hsa043200.30176517
125VEGF signaling pathway_Homo sapiens_hsa043700.28928555
126Chronic myeloid leukemia_Homo sapiens_hsa052200.27664791
127Viral carcinogenesis_Homo sapiens_hsa052030.24502073
128Shigellosis_Homo sapiens_hsa051310.24387316
129Influenza A_Homo sapiens_hsa051640.23349319
130Metabolic pathways_Homo sapiens_hsa011000.23064953
131Pentose phosphate pathway_Homo sapiens_hsa000300.22348838
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22282998
133Inositol phosphate metabolism_Homo sapiens_hsa005620.21888598
134Hepatitis B_Homo sapiens_hsa051610.20960351
135Platelet activation_Homo sapiens_hsa046110.20108293
136Propanoate metabolism_Homo sapiens_hsa006400.19380147
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.19136574
138Hippo signaling pathway_Homo sapiens_hsa043900.18108828
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17976000
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17716161
141Endometrial cancer_Homo sapiens_hsa052130.17398307
142Vitamin digestion and absorption_Homo sapiens_hsa049770.16991104
143Non-small cell lung cancer_Homo sapiens_hsa052230.15394009

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