TLK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.53759315
2mitotic sister chromatid cohesion (GO:0007064)5.44370516
3cytoplasmic mRNA processing body assembly (GO:0033962)4.91191376
4glucocorticoid receptor signaling pathway (GO:0042921)4.74044604
5pre-miRNA processing (GO:0031054)4.62131533
6COPI coating of Golgi vesicle (GO:0048205)4.52228081
7Golgi transport vesicle coating (GO:0048200)4.52228081
8regulation of DNA endoreduplication (GO:0032875)4.48926657
9nuclear pore complex assembly (GO:0051292)4.38604438
10synapsis (GO:0007129)4.25534751
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18127672
12corticosteroid receptor signaling pathway (GO:0031958)4.12418262
13lactate metabolic process (GO:0006089)4.08379387
14nuclear pore organization (GO:0006999)4.05382523
15replication fork processing (GO:0031297)3.97855485
16regulation of meiosis I (GO:0060631)3.95574223
17histone H3-K9 demethylation (GO:0033169)3.87140704
18negative regulation of histone methylation (GO:0031061)3.86923657
19protein targeting to Golgi (GO:0000042)3.78597815
20protein K6-linked ubiquitination (GO:0085020)3.76220756
21insulin-like growth factor receptor signaling pathway (GO:0048009)3.75435285
22somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.74594426
23isotype switching (GO:0045190)3.74594426
24somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.74594426
25chromatin remodeling at centromere (GO:0031055)3.74178479
26histone exchange (GO:0043486)3.70045133
27respiratory chain complex IV assembly (GO:0008535)3.66206710
28positive regulation of protein autophosphorylation (GO:0031954)3.65794404
29water-soluble vitamin biosynthetic process (GO:0042364)3.63060761
30retrograde transport, vesicle recycling within Golgi (GO:0000301)3.61803755
31regulation of RNA export from nucleus (GO:0046831)3.61077604
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.58168995
33regulation of hexokinase activity (GO:1903299)3.54445152
34regulation of glucokinase activity (GO:0033131)3.54445152
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.53166925
36regulation of mitotic spindle checkpoint (GO:1903504)3.53166925
37establishment of protein localization to Golgi (GO:0072600)3.48819496
38peptidyl-lysine dimethylation (GO:0018027)3.48483895
39positive regulation of histone deacetylation (GO:0031065)3.45481571
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.41929932
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.41929932
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.41929932
43proteasome assembly (GO:0043248)3.41699934
44CENP-A containing nucleosome assembly (GO:0034080)3.40899281
45DNA catabolic process, exonucleolytic (GO:0000738)3.37205301
46protein neddylation (GO:0045116)3.36269523
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.35947629
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35947629
49cullin deneddylation (GO:0010388)3.35417818
50protein prenylation (GO:0018342)3.30544039
51prenylation (GO:0097354)3.30544039
52RNA stabilization (GO:0043489)3.29994060
53mRNA stabilization (GO:0048255)3.29994060
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26310816
55negative regulation of cell killing (GO:0031342)3.25468979
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.25468979
57double-strand break repair via homologous recombination (GO:0000724)3.22643949
58NLS-bearing protein import into nucleus (GO:0006607)3.21724379
59recombinational repair (GO:0000725)3.21631633
60regulation of nucleobase-containing compound transport (GO:0032239)3.19719033
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18518000
62telomere maintenance via telomerase (GO:0007004)3.14360475
63DNA replication checkpoint (GO:0000076)3.12240910
64platelet dense granule organization (GO:0060155)3.12043783
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10016407
66response to pheromone (GO:0019236)3.08164674
67pore complex assembly (GO:0046931)3.06974083
68cytochrome complex assembly (GO:0017004)3.04558180
69monoubiquitinated protein deubiquitination (GO:0035520)3.03101724
70histone H2A acetylation (GO:0043968)3.01991813
71regulation of histone H3-K9 methylation (GO:0051570)3.01895379
72regulation of centriole replication (GO:0046599)3.00450211
73keratinocyte development (GO:0003334)2.98992307
74branched-chain amino acid catabolic process (GO:0009083)2.97221402
75vesicle coating (GO:0006901)2.97192215
76protein deneddylation (GO:0000338)2.93370331
77response to X-ray (GO:0010165)2.92749889
78activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.92508985
79positive regulation of nuclease activity (GO:0032075)2.90296952
80negative regulation of DNA recombination (GO:0045910)2.87045978
81mitotic chromosome condensation (GO:0007076)2.85341007
82signal peptide processing (GO:0006465)2.85088635
83inositol phosphate catabolic process (GO:0071545)2.84931855
84intra-S DNA damage checkpoint (GO:0031573)2.83627767
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.83214244
86regulation of translation, ncRNA-mediated (GO:0045974)2.83214244
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83214244
88DNA replication-dependent nucleosome organization (GO:0034723)2.81394074
89DNA replication-dependent nucleosome assembly (GO:0006335)2.81394074
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81076922
91DNA deamination (GO:0045006)2.80747668
92double-strand break repair via nonhomologous end joining (GO:0006303)2.80049511
93non-recombinational repair (GO:0000726)2.80049511
94presynaptic membrane assembly (GO:0097105)2.78870582
95rRNA methylation (GO:0031167)2.74989505
96DNA geometric change (GO:0032392)2.74396985
97mitochondrial DNA replication (GO:0006264)2.74257754
98resolution of meiotic recombination intermediates (GO:0000712)2.73526227
99protein K11-linked deubiquitination (GO:0035871)2.73523960
100spindle checkpoint (GO:0031577)2.73285751
101DNA duplex unwinding (GO:0032508)2.73169635
102positive regulation of DNA-templated transcription, initiation (GO:2000144)2.72717815
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72541048
104negative regulation of DNA repair (GO:0045738)2.70808837
105COPII vesicle coating (GO:0048208)2.70746308
106regulation of nuclease activity (GO:0032069)2.70203196
107histone H4-K12 acetylation (GO:0043983)2.70166378
108mitotic spindle checkpoint (GO:0071174)2.70101165
109heterochromatin organization (GO:0070828)2.69812872
110sister chromatid segregation (GO:0000819)2.69302411
111somatic recombination of immunoglobulin gene segments (GO:0016447)2.68614531
112V(D)J recombination (GO:0033151)2.67029952
113positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65670195
114peptidyl-histidine modification (GO:0018202)2.65147955
115parental behavior (GO:0060746)2.63745546
116negative regulation of histone modification (GO:0031057)2.63674195
117regulation of helicase activity (GO:0051095)2.63412549
118regulation of translational fidelity (GO:0006450)2.60984024
119negative regulation of chromatin modification (GO:1903309)2.60511570
120somatic diversification of immunoglobulins (GO:0016445)2.60440550
121postreplication repair (GO:0006301)2.60214727
122somite rostral/caudal axis specification (GO:0032525)2.59903484
123histone H4-K16 acetylation (GO:0043984)2.59253196
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59203228
125histone mRNA catabolic process (GO:0071044)2.59188608
126double-strand break repair (GO:0006302)2.58945586
127sister chromatid cohesion (GO:0007062)2.58475653
128peptidyl-threonine phosphorylation (GO:0018107)2.58475438
129type B pancreatic cell development (GO:0003323)2.57358537
130polyol catabolic process (GO:0046174)2.57047611
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56809308
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56809308
133positive regulation of hormone biosynthetic process (GO:0046886)2.55871552
134peptidyl-threonine modification (GO:0018210)2.55661168
135membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.55543901
136kinetochore assembly (GO:0051382)2.55036343
137exocrine pancreas development (GO:0031017)2.54612276
138mitotic G2/M transition checkpoint (GO:0044818)2.54241246
139kidney morphogenesis (GO:0060993)2.54185715
140DNA unwinding involved in DNA replication (GO:0006268)2.54112946
141kinetochore organization (GO:0051383)2.53451571
142DNA replication-independent nucleosome assembly (GO:0006336)2.52817830
143DNA replication-independent nucleosome organization (GO:0034724)2.52817830
144L-fucose catabolic process (GO:0042355)2.52289335
145fucose catabolic process (GO:0019317)2.52289335
146L-fucose metabolic process (GO:0042354)2.52289335
147rRNA modification (GO:0000154)2.52160927
148regulation of acyl-CoA biosynthetic process (GO:0050812)2.51019988
149attachment of spindle microtubules to kinetochore (GO:0008608)2.50862841
150regulation of mRNA stability (GO:0043488)2.50623689
151regulation of sister chromatid segregation (GO:0033045)2.50357654
152regulation of mitotic sister chromatid separation (GO:0010965)2.50357654
153regulation of mitotic sister chromatid segregation (GO:0033047)2.50357654
154centriole replication (GO:0007099)2.49365706
155negative regulation of membrane potential (GO:0045837)2.48685387
156positive regulation of SMAD protein import into nucleus (GO:0060391)2.48649639
157L-alpha-amino acid transmembrane transport (GO:1902475)2.47351876
158histone H3-K36 demethylation (GO:0070544)2.47168630
159regulation of sister chromatid cohesion (GO:0007063)2.46711554
160stress granule assembly (GO:0034063)2.46514113
161response to epidermal growth factor (GO:0070849)2.45188111
162positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.45117218
163negative regulation of glycogen biosynthetic process (GO:0045719)2.43169417
164activation of protein kinase A activity (GO:0034199)2.40360719
165histone H3-K4 methylation (GO:0051568)2.39908186
166regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.39894606
167intra-Golgi vesicle-mediated transport (GO:0006891)2.37998489
168embryonic foregut morphogenesis (GO:0048617)2.36979867
169positive regulation of chromosome segregation (GO:0051984)2.35894284
170histone H2A monoubiquitination (GO:0035518)2.35575376
171histone lysine methylation (GO:0034968)2.34852325
172histone lysine demethylation (GO:0070076)2.33085233
173chromatin assembly (GO:0031497)2.29974440
174histone H3-K9 methylation (GO:0051567)2.29786964
175regulation of mRNA catabolic process (GO:0061013)2.29644241
176endoplasmic reticulum unfolded protein response (GO:0030968)2.29037144
177positive T cell selection (GO:0043368)2.28228004
178dorsal/ventral axis specification (GO:0009950)2.27734451
179coronary vasculature morphogenesis (GO:0060977)2.27118853
180regulation of RNA stability (GO:0043487)2.26858642
181protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.26755536
182positive regulation of RNA splicing (GO:0033120)2.26184308
183peptidyl-lysine trimethylation (GO:0018023)2.25388031
184negative regulation of histone acetylation (GO:0035067)2.24398627
185nuclear envelope disassembly (GO:0051081)2.23490056
186membrane disassembly (GO:0030397)2.23490056
187glandular epithelial cell development (GO:0002068)2.23424264
188positive regulation of gene expression, epigenetic (GO:0045815)2.23140744
189ER-nucleus signaling pathway (GO:0006984)2.23094427
190regulation of polysaccharide biosynthetic process (GO:0032885)2.20806450
191definitive hemopoiesis (GO:0060216)2.20592600
192DNA topological change (GO:0006265)2.19996548
193negative regulation of DNA-dependent DNA replication (GO:2000104)2.17765949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37907458
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.74128375
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.05179166
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.85109655
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.73427402
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.47388783
7GATA1_22025678_ChIP-Seq_K562_Human3.29710349
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98365451
9MYC_22102868_ChIP-Seq_BL_Human2.96532772
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86665428
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81501543
12VDR_22108803_ChIP-Seq_LS180_Human2.76161624
13ZNF274_21170338_ChIP-Seq_K562_Hela2.75622302
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.73956147
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.59764780
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49924882
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42954366
18GBX2_23144817_ChIP-Seq_PC3_Human2.36270739
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33971370
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.29285120
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28976087
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28302818
23* P300_19829295_ChIP-Seq_ESCs_Human2.19136502
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17851303
25* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16583463
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.12928215
27ELK1_19687146_ChIP-ChIP_HELA_Human2.12161210
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.11471949
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09515221
30IGF1R_20145208_ChIP-Seq_DFB_Human2.08426789
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.05322913
32TAF15_26573619_Chip-Seq_HEK293_Human2.04455830
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98402225
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.95192470
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92083327
36* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.91395641
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91176508
38TCF7_22412390_ChIP-Seq_EML_Mouse1.90755314
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89853080
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85536696
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.83307960
42FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.80981082
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76566486
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75386427
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.73560413
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72512716
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67764313
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63625284
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62041389
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.58066835
51ER_23166858_ChIP-Seq_MCF-7_Human1.54188060
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53317167
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52355043
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51681006
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51341393
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50240693
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50001867
58BCAT_22108803_ChIP-Seq_LS180_Human1.49891439
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.49752551
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48523284
61* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48479978
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47039853
63VDR_23849224_ChIP-Seq_CD4+_Human1.46953806
64* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45542629
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.45175158
66SMAD4_21799915_ChIP-Seq_A2780_Human1.44176106
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43968568
68* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43102279
69CHD1_26751641_Chip-Seq_LNCaP_Human1.42969005
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40466372
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38926187
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38180329
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37955237
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37542140
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.35639672
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35579659
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35488542
78MYC_18940864_ChIP-ChIP_HL60_Human1.35157992
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.34672387
80NANOG_19829295_ChIP-Seq_ESCs_Human1.34587783
81SOX2_19829295_ChIP-Seq_ESCs_Human1.34587783
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34450987
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33827070
84AR_25329375_ChIP-Seq_VCAP_Human1.33202491
85CLOCK_20551151_ChIP-Seq_293T_Human1.31018544
86* GATA1_19941826_ChIP-Seq_K562_Human1.30951075
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29832811
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29705249
89KDM2B_26808549_Chip-Seq_DND41_Human1.29622407
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.28694143
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28604182
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.28577657
93CBP_20019798_ChIP-Seq_JUKART_Human1.27866743
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27866743
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.27527229
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27517242
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.27295791
98* P53_22387025_ChIP-Seq_ESCs_Mouse1.26994072
99* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26848190
100RUNX_20019798_ChIP-Seq_JUKART_Human1.25215189
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23995692
102TCF4_22108803_ChIP-Seq_LS180_Human1.23620918
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23222821
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22784266
105MYB_26560356_Chip-Seq_TH2_Human1.21257973
106* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20661202
107FOXP3_21729870_ChIP-Seq_TREG_Human1.20372199
108* AR_21909140_ChIP-Seq_LNCAP_Human1.20353801
109CDX2_22108803_ChIP-Seq_LS180_Human1.19974263
110* P300_18555785_Chip-Seq_ESCs_Mouse1.19791136
111BRD4_25478319_ChIP-Seq_HGPS_Human1.19650611
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17984669
113* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17454981
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17392016
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15377918
116* E2F1_18555785_Chip-Seq_ESCs_Mouse1.14936198
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.14863358
118MYB_26560356_Chip-Seq_TH1_Human1.14237144
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13263427
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13137852
121* TCF4_23295773_ChIP-Seq_U87_Human1.12524998
122CIITA_25753668_ChIP-Seq_RAJI_Human1.11907382
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11853561
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11574278
125* STAT3_18555785_Chip-Seq_ESCs_Mouse1.11556476
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09399151
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09087599
128* ISL1_27105846_Chip-Seq_CPCs_Mouse1.08913778
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08853891
130SCL_19346495_ChIP-Seq_HPC-7_Human1.08637151
131ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06957355
132FOXA1_25329375_ChIP-Seq_VCAP_Human1.06842587
133FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06842587
134* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06374331
135TP53_16413492_ChIP-PET_HCT116_Human1.06210110
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06208210
137* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05686933
138SOX2_18555785_Chip-Seq_ESCs_Mouse1.05680196
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04901546
140RARB_27405468_Chip-Seq_BRAIN_Mouse1.04588683
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04063741
142* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03973991
143TP53_22573176_ChIP-Seq_HFKS_Human1.03955352
144* OCT4_18555785_Chip-Seq_ESCs_Mouse1.03158791
145SMAD4_21741376_ChIP-Seq_EPCs_Human1.02833675
146* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02729017
147FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02427897
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02191033
149SRF_21415370_ChIP-Seq_HL-1_Mouse1.00932263
150FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00923599
151WT1_19549856_ChIP-ChIP_CCG9911_Human1.00211424
152NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00164580
153KDM2B_26808549_Chip-Seq_JURKAT_Human1.00127875
154NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00028880
155RXR_22108803_ChIP-Seq_LS180_Human0.99979255
156FLI1_21867929_ChIP-Seq_TH2_Mouse0.99782657
157* RUNX2_22187159_ChIP-Seq_PCA_Human0.99657483
158ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99562162
159ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98506543
160SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97733227
161AHR_22903824_ChIP-Seq_MCF-7_Human0.97645105
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.97033461
163TP63_19390658_ChIP-ChIP_HaCaT_Human0.95215937
164* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94318545
165* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94315695
166GATA3_27048872_Chip-Seq_THYMUS_Human0.93456070
167IRF8_22096565_ChIP-ChIP_GC-B_Human0.92880141
168FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92860064
169FUS_26573619_Chip-Seq_HEK293_Human0.92668257
170SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92278751
171GATA6_25053715_ChIP-Seq_YYC3_Human0.91940628
172MAF_26560356_Chip-Seq_TH1_Human0.91346112
173* STAT3_23295773_ChIP-Seq_U87_Human0.91000623
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90958124
175* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90837680
176NCOR1_26117541_ChIP-Seq_K562_Human0.89575640
177AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89553864
178FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89313941
179TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88628820
180ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87555701
181EWS_26573619_Chip-Seq_HEK293_Human0.86846825
182BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86415465
183CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86339335
184P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85769613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.96449166
2MP0003300_gastrointestinal_ulcer3.40378402
3MP0003123_paternal_imprinting3.36279375
4MP0002877_abnormal_melanocyte_morpholog3.35498891
5MP0003195_calcinosis3.32507329
6MP0002102_abnormal_ear_morphology3.09831348
7MP0010234_abnormal_vibrissa_follicle3.06355607
8MP0010352_gastrointestinal_tract_polyps2.98593083
9MP0008058_abnormal_DNA_repair2.95808559
10MP0003787_abnormal_imprinting2.74864246
11MP0005076_abnormal_cell_differentiation2.67703851
12MP0003705_abnormal_hypodermis_morpholog2.55226978
13MP0003121_genomic_imprinting2.40165455
14MP0006072_abnormal_retinal_apoptosis2.32487972
15MP0004264_abnormal_extraembryonic_tissu2.28400268
16MP0003890_abnormal_embryonic-extraembry2.22791726
17MP0006054_spinal_hemorrhage2.10004281
18MP0002009_preneoplasia2.09295068
19MP0009780_abnormal_chondrocyte_physiolo2.08910775
20MP0002166_altered_tumor_susceptibility2.02433700
21MP0001984_abnormal_olfaction2.01555183
22MP0003786_premature_aging1.98696572
23MP0002254_reproductive_system_inflammat1.98186149
24MP0003718_maternal_effect1.97992001
25MP0002938_white_spotting1.97957227
26MP0000372_irregular_coat_pigmentation1.97355810
27MP0008057_abnormal_DNA_replication1.96847551
28MP0010307_abnormal_tumor_latency1.95309443
29MP0002837_dystrophic_cardiac_calcinosis1.86651213
30MP0003941_abnormal_skin_development1.82717930
31MP0001188_hyperpigmentation1.82319985
32MP0003122_maternal_imprinting1.81703121
33MP0009703_decreased_birth_body1.80418433
34MP0005551_abnormal_eye_electrophysiolog1.79071880
35MP0005075_abnormal_melanosome_morpholog1.72688107
36MP0005253_abnormal_eye_physiology1.71751383
37MP0000516_abnormal_urinary_system1.70930914
38MP0005367_renal/urinary_system_phenotyp1.70930914
39MP0010094_abnormal_chromosome_stability1.70055796
40MP0003868_abnormal_feces_composition1.69772311
41MP0004043_abnormal_pH_regulation1.69204837
42MP0002086_abnormal_extraembryonic_tissu1.65775203
43MP0008961_abnormal_basal_metabolism1.65687519
44MP0002396_abnormal_hematopoietic_system1.65514209
45MP0002909_abnormal_adrenal_gland1.65404272
46MP0004197_abnormal_fetal_growth/weight/1.62129230
47MP0002090_abnormal_vision1.60788415
48MP0009053_abnormal_anal_canal1.57294784
49MP0004808_abnormal_hematopoietic_stem1.56715292
50MP0009672_abnormal_birth_weight1.53341584
51MP0003567_abnormal_fetal_cardiomyocyte1.52524358
52MP0005187_abnormal_penis_morphology1.47107100
53MP0008877_abnormal_DNA_methylation1.46754388
54MP0002693_abnormal_pancreas_physiology1.46647761
55MP0001944_abnormal_pancreas_morphology1.46524872
56MP0002736_abnormal_nociception_after1.45798264
57MP0001730_embryonic_growth_arrest1.45558029
58MP0008872_abnormal_physiological_respon1.42683602
59MP0005220_abnormal_exocrine_pancreas1.41130682
60MP0002751_abnormal_autonomic_nervous1.40235747
61MP0002088_abnormal_embryonic_growth/wei1.36814565
62MP0006036_abnormal_mitochondrial_physio1.35528887
63MP0006292_abnormal_olfactory_placode1.34858646
64MP0004215_abnormal_myocardial_fiber1.34540878
65MP0000003_abnormal_adipose_tissue1.33363802
66MP0003984_embryonic_growth_retardation1.33359261
67MP0003252_abnormal_bile_duct1.32835976
68MP0005645_abnormal_hypothalamus_physiol1.32162168
69MP0002084_abnormal_developmental_patter1.30559095
70MP0001672_abnormal_embryogenesis/_devel1.27281195
71MP0005380_embryogenesis_phenotype1.27281195
72MP0010678_abnormal_skin_adnexa1.25304915
73MP0000537_abnormal_urethra_morphology1.25177768
74MP0005365_abnormal_bile_salt1.25055717
75MP0002928_abnormal_bile_duct1.23802136
76MP0004859_abnormal_synaptic_plasticity1.23752359
77MP0003693_abnormal_embryo_hatching1.21224826
78MP0000427_abnormal_hair_cycle1.19954084
79MP0001697_abnormal_embryo_size1.19633340
80MP0005646_abnormal_pituitary_gland1.18484195
81MP0002006_tumorigenesis1.17722859
82MP0001929_abnormal_gametogenesis1.17495039
83MP0005085_abnormal_gallbladder_physiolo1.17477337
84MP0005174_abnormal_tail_pigmentation1.16953398
85MP0000350_abnormal_cell_proliferation1.15454893
86MP0000647_abnormal_sebaceous_gland1.14911557
87MP0003183_abnormal_peptide_metabolism1.14171857
88MP0000703_abnormal_thymus_morphology1.13588837
89MP0006035_abnormal_mitochondrial_morpho1.11270025
90MP0009046_muscle_twitch1.11238376
91MP0003077_abnormal_cell_cycle1.10758084
92MP0005395_other_phenotype1.10014598
93MP0003763_abnormal_thymus_physiology1.09673100
94MP0003111_abnormal_nucleus_morphology1.09551711
95MP0001485_abnormal_pinna_reflex1.07567392
96MP0001968_abnormal_touch/_nociception1.05628220
97MP0003119_abnormal_digestive_system1.04195826
98MP0008932_abnormal_embryonic_tissue1.02365953
99MP0004957_abnormal_blastocyst_morpholog1.02155207
100MP0000653_abnormal_sex_gland1.00495196
101MP0002896_abnormal_bone_mineralization0.99212672
102MP0002925_abnormal_cardiovascular_devel0.98528671
103MP0004147_increased_porphyrin_level0.97285867
104MP0005084_abnormal_gallbladder_morpholo0.96667765
105MP0005310_abnormal_salivary_gland0.96259183
106MP0003656_abnormal_erythrocyte_physiolo0.94380094
107MP0000266_abnormal_heart_morphology0.94299823
108MP0003937_abnormal_limbs/digits/tail_de0.94092402
109MP0001293_anophthalmia0.93885764
110MP0010368_abnormal_lymphatic_system0.93825628
111MP0000631_abnormal_neuroendocrine_gland0.93287393
112MP0002139_abnormal_hepatobiliary_system0.91360668
113MP0002210_abnormal_sex_determination0.90055756
114MP0003303_peritoneal_inflammation0.90006822
115MP0001666_abnormal_nutrient_absorption0.88876095
116MP0002080_prenatal_lethality0.88581267
117MP0000383_abnormal_hair_follicle0.87566453
118MP0002078_abnormal_glucose_homeostasis0.86980727
119MP0003283_abnormal_digestive_organ0.86613163
120MP0005379_endocrine/exocrine_gland_phen0.86284876
121MP0001486_abnormal_startle_reflex0.86274790
122MP0001145_abnormal_male_reproductive0.86137487
123MP0001119_abnormal_female_reproductive0.85437675
124MP0003698_abnormal_male_reproductive0.85435224
125MP0003943_abnormal_hepatobiliary_system0.84892233
126MP0005332_abnormal_amino_acid0.84678307
127MP0005248_abnormal_Harderian_gland0.84246295
128MP0000015_abnormal_ear_pigmentation0.83772238
129MP0001879_abnormal_lymphatic_vessel0.83384753
130MP0003935_abnormal_craniofacial_develop0.82374938
131MP0002638_abnormal_pupillary_reflex0.81907524
132MP0002085_abnormal_embryonic_tissue0.81033189
133MP0005397_hematopoietic_system_phenotyp0.81001446
134MP0001545_abnormal_hematopoietic_system0.81001446
135MP0009745_abnormal_behavioral_response0.80577236
136MP0000013_abnormal_adipose_tissue0.80409612
137MP0003137_abnormal_impulse_conducting0.79785529
138MP0003566_abnormal_cell_adhesion0.79422958
139MP0001324_abnormal_eye_pigmentation0.78428286
140MP0005389_reproductive_system_phenotype0.78340499
141MP0001529_abnormal_vocalization0.78291142
142MP0002398_abnormal_bone_marrow0.78108190
143MP0010630_abnormal_cardiac_muscle0.78084788
144MP0003011_delayed_dark_adaptation0.77912407
145MP0001764_abnormal_homeostasis0.77216849
146MP0009697_abnormal_copulation0.76701982
147MP0002163_abnormal_gland_morphology0.76381475
148MP0001661_extended_life_span0.75637980
149MP0001784_abnormal_fluid_regulation0.75632833
150MP0008775_abnormal_heart_ventricle0.75541898
151MP0003115_abnormal_respiratory_system0.75513769
152MP0002160_abnormal_reproductive_system0.74849361
153MP0008789_abnormal_olfactory_epithelium0.74534916
154MP0002138_abnormal_hepatobiliary_system0.74417853
155MP0003806_abnormal_nucleotide_metabolis0.74337160
156MP0004133_heterotaxia0.74016830
157MP0008007_abnormal_cellular_replicative0.73817903
158MP0003880_abnormal_central_pattern0.73453483
159MP0001177_atelectasis0.72879513
160MP0008770_decreased_survivor_rate0.72514957
161MP0003186_abnormal_redox_activity0.69845075
162MP0001915_intracranial_hemorrhage0.68891200
163MP0001849_ear_inflammation0.68403513
164MP0000477_abnormal_intestine_morphology0.66889162
165MP0000428_abnormal_craniofacial_morphol0.62875195
166MP0005360_urolithiasis0.61723638
167MP0000598_abnormal_liver_morphology0.60016924

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.82787846
2Abnormality of the labia minora (HP:0012880)3.68702576
3Macroorchidism (HP:0000053)3.60453372
4Abnormality of the fingertips (HP:0001211)3.49011500
5Hypothermia (HP:0002045)3.41894803
6Subacute progressive viral hepatitis (HP:0006572)3.37690434
7Hepatoblastoma (HP:0002884)3.24009467
8Vertebral arch anomaly (HP:0008438)3.14580576
9Hypochromic microcytic anemia (HP:0004840)3.08095680
10Intestinal atresia (HP:0011100)3.06868833
11Methylmalonic acidemia (HP:0002912)3.01705516
12Abnormality of chromosome stability (HP:0003220)2.97430528
13Papillary thyroid carcinoma (HP:0002895)2.92163601
14Pancreatic cysts (HP:0001737)2.88379259
15Neoplasm of the adrenal gland (HP:0100631)2.88376907
16Pancreatic fibrosis (HP:0100732)2.76834404
17Truncal obesity (HP:0001956)2.76472337
18Thyroiditis (HP:0100646)2.74798705
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72666079
20Chromsome breakage (HP:0040012)2.67483630
21Short 4th metacarpal (HP:0010044)2.64158626
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64158626
23Hypoglycemic coma (HP:0001325)2.61576171
24Neoplasm of the adrenal cortex (HP:0100641)2.56271589
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.56117175
26True hermaphroditism (HP:0010459)2.56021042
27Pancreatic islet-cell hyperplasia (HP:0004510)2.55328452
28Biliary tract neoplasm (HP:0100574)2.53959483
29Hypoplastic labia majora (HP:0000059)2.48362065
30Nephronophthisis (HP:0000090)2.47475406
31Meckel diverticulum (HP:0002245)2.47406614
32Aqueductal stenosis (HP:0002410)2.46946044
33Abolished electroretinogram (ERG) (HP:0000550)2.44794523
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42597835
35Abnormality of the ileum (HP:0001549)2.40123546
36Breast carcinoma (HP:0003002)2.38029596
37Asymmetry of the thorax (HP:0001555)2.37116250
38Molar tooth sign on MRI (HP:0002419)2.37045003
39Abnormality of midbrain morphology (HP:0002418)2.37045003
40Ankyloglossia (HP:0010296)2.36701620
41Obsessive-compulsive behavior (HP:0000722)2.35993924
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.35677339
43Hypoplasia of the fovea (HP:0007750)2.35677339
44Rhabdomyosarcoma (HP:0002859)2.35137925
45Abnormality of endocrine pancreas physiology (HP:0012093)2.33492751
46Abnormality of the pancreatic islet cells (HP:0006476)2.33492751
47Papilledema (HP:0001085)2.31300124
48Methylmalonic aciduria (HP:0012120)2.29271135
49Abnormality of vitamin B metabolism (HP:0004340)2.29269333
50Abnormality of methionine metabolism (HP:0010901)2.28844286
51Progressive macrocephaly (HP:0004481)2.28704349
52Colon cancer (HP:0003003)2.27989034
53Narrow palate (HP:0000189)2.27654056
54Urethral obstruction (HP:0000796)2.24489292
55Hematochezia (HP:0002573)2.22486447
56Abnormality of the preputium (HP:0100587)2.20699494
57Abnormal pancreas size (HP:0012094)2.19257713
58Gastrointestinal carcinoma (HP:0002672)2.19203090
59Malignant gastrointestinal tract tumors (HP:0006749)2.19203090
60Abnormality of oral frenula (HP:0000190)2.18707748
61Ketoacidosis (HP:0001993)2.18091167
62Medial flaring of the eyebrow (HP:0010747)2.18051188
63Abnormal biliary tract morphology (HP:0012440)2.17786568
64Thyroid carcinoma (HP:0002890)2.15670992
65Abnormality of the duodenum (HP:0002246)2.14516582
66T lymphocytopenia (HP:0005403)2.14479148
67Abnormality of the labia majora (HP:0012881)2.14431499
68Long eyelashes (HP:0000527)2.14136753
69Hyperglycemia (HP:0003074)2.14047046
70Broad palm (HP:0001169)2.13494425
71Diastasis recti (HP:0001540)2.13306071
72Abnormality of the fovea (HP:0000493)2.13297321
73Enlarged penis (HP:0000040)2.12686029
74Transitional cell carcinoma of the bladder (HP:0006740)2.12521777
75Rectal prolapse (HP:0002035)2.12303523
76Tongue fasciculations (HP:0001308)2.10586961
77Abnormality of the renal cortex (HP:0011035)2.10355073
78Abnormality of the renal medulla (HP:0100957)2.09702923
79Congenital stationary night blindness (HP:0007642)2.09109972
80Progressive inability to walk (HP:0002505)2.08987691
81Hamartoma of the eye (HP:0010568)2.07560106
82Deep philtrum (HP:0002002)2.07515049
83Duodenal stenosis (HP:0100867)2.07358166
84Small intestinal stenosis (HP:0012848)2.07358166
85Hyperglycinemia (HP:0002154)2.05719370
86Sloping forehead (HP:0000340)2.05626286
87Abnormal lung lobation (HP:0002101)2.05115479
88Bladder carcinoma (HP:0002862)2.02935793
89Bladder neoplasm (HP:0009725)2.02935793
90Basal cell carcinoma (HP:0002671)2.02081680
91Intestinal polyposis (HP:0200008)1.99994045
92Intestinal polyp (HP:0005266)1.99676525
93Symptomatic seizures (HP:0011145)1.99632373
94Low anterior hairline (HP:0000294)1.99437176
95Ependymoma (HP:0002888)1.98211839
96Ectopic kidney (HP:0000086)1.97646837
97Hyperkalemia (HP:0002153)1.97008103
98Limb hypertonia (HP:0002509)1.94651191
99Hypomagnesemia (HP:0002917)1.94180669
100Abnormality of T cell number (HP:0011839)1.93936956
101Hepatocellular carcinoma (HP:0001402)1.93569098
102Acute encephalopathy (HP:0006846)1.92065474
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92040461
104Decreased circulating renin level (HP:0003351)1.91816420
105Hyperinsulinemic hypoglycemia (HP:0000825)1.91596405
106Clubbing of toes (HP:0100760)1.91383849
107Viral hepatitis (HP:0006562)1.89146508
108Abnormality of serine family amino acid metabolism (HP:0010894)1.89093014
109Abnormality of glycine metabolism (HP:0010895)1.89093014
110Abnormality of the vitamin B12 metabolism (HP:0004341)1.88993340
111Conjunctival hamartoma (HP:0100780)1.88961117
112Acute necrotizing encephalopathy (HP:0006965)1.88255915
113Increased CSF lactate (HP:0002490)1.88078268
114Broad thumb (HP:0011304)1.88023077
115Thick eyebrow (HP:0000574)1.87959225
116Supernumerary spleens (HP:0009799)1.87911678
117Increased nuchal translucency (HP:0010880)1.87741366
118Medulloblastoma (HP:0002885)1.87001820
119Cutaneous melanoma (HP:0012056)1.85104889
120Abnormality of the metopic suture (HP:0005556)1.84850511
121Pendular nystagmus (HP:0012043)1.84633090
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.84138151
123Uterine neoplasm (HP:0010784)1.83032172
124Disproportionate short-trunk short stature (HP:0003521)1.81987065
125Furrowed tongue (HP:0000221)1.80954399
126Abnormality of the 4th metacarpal (HP:0010012)1.80870751
127Prominent metopic ridge (HP:0005487)1.79697017
128Abnormality of the astrocytes (HP:0100707)1.78715913
129Astrocytoma (HP:0009592)1.78715913
130Sandal gap (HP:0001852)1.77971910
131Hyperglycinuria (HP:0003108)1.77962592
132Neoplasm of the liver (HP:0002896)1.76616886
133Lymphangioma (HP:0100764)1.76065202
134Hypoglycemic seizures (HP:0002173)1.76031764
135Cutis marmorata (HP:0000965)1.75831699
136Acute myeloid leukemia (HP:0004808)1.75814293
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75555765
138Gaze-evoked nystagmus (HP:0000640)1.75220935
139Abnormality of serum amino acid levels (HP:0003112)1.74173411
140Neoplasm of the small intestine (HP:0100833)1.73200260
141Renal cortical cysts (HP:0000803)1.72898123
142Exostoses (HP:0100777)1.71652453
143Genital tract atresia (HP:0001827)1.69650861
144Heterotopia (HP:0002282)1.69568439
145Hypoplasia of the maxilla (HP:0000327)1.69065656
146Glioma (HP:0009733)1.69005902
147Angiofibromas (HP:0010615)1.68666670
148Adenoma sebaceum (HP:0009720)1.68666670
149Absent frontal sinuses (HP:0002688)1.68505331
150Smooth philtrum (HP:0000319)1.67783161
151Decreased central vision (HP:0007663)1.67056674
152Congenital primary aphakia (HP:0007707)1.66783106
153Supernumerary ribs (HP:0005815)1.66114253
154Attenuation of retinal blood vessels (HP:0007843)1.65930650
155Muscle fibrillation (HP:0010546)1.65674413
156Nephroblastoma (Wilms tumor) (HP:0002667)1.65524476
157Poikilocytosis (HP:0004447)1.64802923
158Sensory axonal neuropathy (HP:0003390)1.64439486
159Fair hair (HP:0002286)1.64109245
160Lip pit (HP:0100267)1.63679202
161Gastrointestinal atresia (HP:0002589)1.63659074
162Mitochondrial inheritance (HP:0001427)1.62974188
163Leiomyosarcoma (HP:0100243)1.62616181
164Uterine leiomyosarcoma (HP:0002891)1.62616181
165Neoplasm of the thyroid gland (HP:0100031)1.62392002
166Neoplasm of striated muscle (HP:0009728)1.61610755
167Abnormality of B cell number (HP:0010975)1.61203357
168B lymphocytopenia (HP:0010976)1.61203357
169Testicular neoplasm (HP:0010788)1.60975345
170Micronodular cirrhosis (HP:0001413)1.60758915
171Mitral valve prolapse (HP:0001634)1.59417936
172Deviation of the thumb (HP:0009603)1.58775610
173Ovarian neoplasm (HP:0100615)1.58211472
174Spondylolisthesis (HP:0003302)1.57854147
175Dysmetric saccades (HP:0000641)1.57565274
176Neoplasm of the oral cavity (HP:0100649)1.56781303
177Renal duplication (HP:0000075)1.56657433
178Striae distensae (HP:0001065)1.56535748
179Skull defect (HP:0001362)1.55365326
180Resting tremor (HP:0002322)1.55219173
181Fibrous tissue neoplasm (HP:0012316)1.54899690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.02463297
2CDK123.92924836
3ACVR1B3.41029954
4PKN23.35869897
5MST42.91363730
6WNK32.84872671
7FRK2.64487371
8BMPR1B2.60563875
9EIF2AK32.53267819
10TNIK2.48089276
11LATS12.28231941
12PRKD32.25751565
13EIF2AK12.22619781
14CDC72.21182677
15TRIB32.14474610
16MAP3K102.13782077
17BUB12.12856319
18BRD42.00615204
19MAP3K22.00063435
20CDK61.90830062
21ERBB31.88433217
22PLK41.86034929
23MAP4K21.85713368
24SCYL21.85508884
25NUAK11.84156974
26AKT31.81680955
27PASK1.70026163
28SIK31.69925411
29CAMK1G1.67235213
30ZAK1.65462181
31BRSK21.62954034
32EEF2K1.61201817
33SGK31.59941245
34FGFR31.56836239
35RET1.49034212
36WEE11.43794542
37PDGFRA1.43694014
38CAMK1D1.43432245
39GRK11.43192823
40SGK21.43138019
41TAOK31.39611350
42INSRR1.36184639
43FLT31.35728733
44STK391.34747002
45BCR1.33583486
46RIPK11.31300362
47PTK61.29563027
48TTK1.24788898
49MAP3K71.23457991
50HIPK21.20961231
51STK241.20247424
52OXSR11.20151068
53STK31.19693697
54TAF11.19406992
55ALK1.12729784
56MAP3K41.11449570
57NTRK31.10210518
58MELK1.09715700
59FGFR21.09606876
60CASK1.08072405
61ADRBK21.07400690
62PRKCH1.06464828
63CAMKK11.05095995
64NLK1.04846566
65CSNK1G11.03417387
66GRK61.01799669
67STK38L1.00359716
68PNCK1.00175462
69PDGFRB0.99853831
70KSR10.92464471
71MTOR0.91814294
72PLK10.90830035
73PLK30.89957800
74MAP4K10.89261577
75CDK40.88806131
76ATM0.86724425
77VRK10.86699814
78NEK20.86601282
79PAK30.86425867
80EPHA40.86100536
81FER0.85748343
82MAPK130.84230478
83ITK0.84158934
84CSNK1G20.83626025
85PINK10.83199141
86SIK20.83121977
87EIF2AK20.82899815
88STK100.82806816
89DAPK20.82787475
90VRK20.81362981
91DMPK0.80202900
92CSNK1G30.79084644
93CDC42BPA0.78625999
94FGFR10.75206111
95WNK10.72581325
96MAP2K40.70782880
97PLK20.69211028
98CDK90.68736371
99RPS6KA20.67295667
100SGK10.67102139
101PRKCE0.66660573
102JAK20.65516028
103LRRK20.65091349
104RPS6KB10.64229294
105NEK90.63603130
106SRPK10.62953856
107* CHEK10.60294559
108JAK30.59614253
109STK160.58707686
110PTK2B0.55840215
111STK40.55678803
112* CDK20.54816590
113YES10.54338904
114CSNK1A1L0.54277467
115PHKG10.53222438
116PHKG20.53222438
117WNK40.52994333
118TXK0.52987428
119CSNK1D0.52851363
120MAPK140.52740441
121JAK10.52497451
122PRKCG0.51448208
123PRKDC0.50998087
124MAPK100.50667483
125TEC0.50205413
126ATR0.48803551
127MKNK20.48398597
128GRK50.46724002
129MARK30.46629999
130NEK10.46249342
131TGFBR20.45772260
132IRAK10.45559975
133CHUK0.43328945
134BRSK10.42951927
135MAP3K10.42928493
136DAPK10.42457003
137PTK20.42158702
138MKNK10.41710235
139PBK0.40730384
140SGK2230.40217790
141SGK4940.40217790
142MINK10.40170909
143RPS6KA40.40045032
144CSNK1E0.39422876
145TSSK60.39153312
146TGFBR10.38966162
147GSK3B0.38801756
148CDK10.38048449
149PRKCI0.37669898
150TRPM70.37408472
151MAP3K130.37038948
152PDK10.35873508
153RPS6KA30.35611912
154CDK30.34906687
155DYRK20.30985330
156ADRBK10.25961804
157CHEK20.25494876
158IRAK20.23616100
159CSNK2A10.22783792
160CSNK1A10.22503150
161BMPR20.21915536
162CAMK2A0.21176696
163ROCK10.20283964
164PRKG10.19924048
165CCNB10.19520694

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.59734265
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95642705
3Vitamin B6 metabolism_Homo sapiens_hsa007502.85296612
4Propanoate metabolism_Homo sapiens_hsa006402.74241483
5Proteasome_Homo sapiens_hsa030502.68970415
6Homologous recombination_Homo sapiens_hsa034402.53469740
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46375325
8Mismatch repair_Homo sapiens_hsa034302.42989902
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.21433012
10Fanconi anemia pathway_Homo sapiens_hsa034602.20772438
11Basal transcription factors_Homo sapiens_hsa030222.13930825
12Butanoate metabolism_Homo sapiens_hsa006502.05533262
13Fatty acid elongation_Homo sapiens_hsa000622.03900414
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00834271
15Type II diabetes mellitus_Homo sapiens_hsa049301.93225105
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89451762
17RNA degradation_Homo sapiens_hsa030181.86612730
18mTOR signaling pathway_Homo sapiens_hsa041501.82159821
19Lysine degradation_Homo sapiens_hsa003101.79476826
20Steroid biosynthesis_Homo sapiens_hsa001001.74841112
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70471790
22Nitrogen metabolism_Homo sapiens_hsa009101.66622322
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66376880
24Long-term potentiation_Homo sapiens_hsa047201.63363903
25RNA polymerase_Homo sapiens_hsa030201.60983232
26Insulin secretion_Homo sapiens_hsa049111.59153905
27Chronic myeloid leukemia_Homo sapiens_hsa052201.56483624
28Phototransduction_Homo sapiens_hsa047441.52472632
29Endometrial cancer_Homo sapiens_hsa052131.49732606
30Thyroid cancer_Homo sapiens_hsa052161.44593237
31Glioma_Homo sapiens_hsa052141.44148499
32Non-small cell lung cancer_Homo sapiens_hsa052231.43782873
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.42527263
34Adherens junction_Homo sapiens_hsa045201.41016094
35Insulin resistance_Homo sapiens_hsa049311.40822430
36RNA transport_Homo sapiens_hsa030131.39929111
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38839021
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35387373
39Amphetamine addiction_Homo sapiens_hsa050311.34875562
40Prostate cancer_Homo sapiens_hsa052151.33498415
41Olfactory transduction_Homo sapiens_hsa047401.33131883
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31144165
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30539077
44Colorectal cancer_Homo sapiens_hsa052101.28710151
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.27686148
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26664058
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26588779
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26538607
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.25244845
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19844940
51Caffeine metabolism_Homo sapiens_hsa002321.18270383
52Dorso-ventral axis formation_Homo sapiens_hsa043201.17326916
53DNA replication_Homo sapiens_hsa030301.16592063
54Estrogen signaling pathway_Homo sapiens_hsa049151.16566954
55Tryptophan metabolism_Homo sapiens_hsa003801.15992887
56Glucagon signaling pathway_Homo sapiens_hsa049221.15371917
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14715802
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14472984
59Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13545003
60Pancreatic cancer_Homo sapiens_hsa052121.13149247
61Thyroid hormone synthesis_Homo sapiens_hsa049181.12156610
62T cell receptor signaling pathway_Homo sapiens_hsa046601.11493369
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10860774
64Ether lipid metabolism_Homo sapiens_hsa005651.10789630
65Sulfur metabolism_Homo sapiens_hsa009201.09856704
66Dopaminergic synapse_Homo sapiens_hsa047281.07686386
67Non-homologous end-joining_Homo sapiens_hsa034501.07508221
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06565227
69Nucleotide excision repair_Homo sapiens_hsa034201.06299218
70Peroxisome_Homo sapiens_hsa041461.05647408
71FoxO signaling pathway_Homo sapiens_hsa040681.04374693
72Renin secretion_Homo sapiens_hsa049241.04145384
73Prolactin signaling pathway_Homo sapiens_hsa049171.02871422
74Insulin signaling pathway_Homo sapiens_hsa049101.02215488
75mRNA surveillance pathway_Homo sapiens_hsa030151.00939391
76beta-Alanine metabolism_Homo sapiens_hsa004101.00239708
77MicroRNAs in cancer_Homo sapiens_hsa052061.00175100
78Fatty acid metabolism_Homo sapiens_hsa012120.99628402
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99018343
80B cell receptor signaling pathway_Homo sapiens_hsa046620.98510074
81Regulation of autophagy_Homo sapiens_hsa041400.97353389
82Oocyte meiosis_Homo sapiens_hsa041140.96681253
83Purine metabolism_Homo sapiens_hsa002300.95584613
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95075216
85Cocaine addiction_Homo sapiens_hsa050300.94289974
86Selenocompound metabolism_Homo sapiens_hsa004500.93811666
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93573185
88Fatty acid degradation_Homo sapiens_hsa000710.91994737
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91738182
90Linoleic acid metabolism_Homo sapiens_hsa005910.90091555
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89522913
92Platelet activation_Homo sapiens_hsa046110.88656971
93Cholinergic synapse_Homo sapiens_hsa047250.88394167
94Cell cycle_Homo sapiens_hsa041100.87476897
95Antigen processing and presentation_Homo sapiens_hsa046120.87175501
96Small cell lung cancer_Homo sapiens_hsa052220.86179977
97Oxidative phosphorylation_Homo sapiens_hsa001900.84406643
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.83576322
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82221605
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81585140
101Pyruvate metabolism_Homo sapiens_hsa006200.81373644
102p53 signaling pathway_Homo sapiens_hsa041150.81352814
103Hepatitis B_Homo sapiens_hsa051610.80741619
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80111040
105Proteoglycans in cancer_Homo sapiens_hsa052050.79793405
106Retinol metabolism_Homo sapiens_hsa008300.79152857
107Base excision repair_Homo sapiens_hsa034100.78199756
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77451865
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77411006
110Melanogenesis_Homo sapiens_hsa049160.77288712
111Glutathione metabolism_Homo sapiens_hsa004800.77237704
112Gastric acid secretion_Homo sapiens_hsa049710.76685769
113Collecting duct acid secretion_Homo sapiens_hsa049660.76478635
114cAMP signaling pathway_Homo sapiens_hsa040240.76276681
115Oxytocin signaling pathway_Homo sapiens_hsa049210.74954159
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73658630
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.73484014
118Acute myeloid leukemia_Homo sapiens_hsa052210.72982348
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72932988
120HTLV-I infection_Homo sapiens_hsa051660.71964731
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71476134
122Focal adhesion_Homo sapiens_hsa045100.71452197
123Circadian entrainment_Homo sapiens_hsa047130.71175368
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70850279
125GnRH signaling pathway_Homo sapiens_hsa049120.70562034
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70111294
127AMPK signaling pathway_Homo sapiens_hsa041520.70105544
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69751292
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68885538
130Pancreatic secretion_Homo sapiens_hsa049720.67135279
131Viral carcinogenesis_Homo sapiens_hsa052030.67032342
132Choline metabolism in cancer_Homo sapiens_hsa052310.66223374
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66035418
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65644964
135Wnt signaling pathway_Homo sapiens_hsa043100.65414337
136ErbB signaling pathway_Homo sapiens_hsa040120.65347620
137Pyrimidine metabolism_Homo sapiens_hsa002400.65339044
138Parkinsons disease_Homo sapiens_hsa050120.64467234
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63700312
140VEGF signaling pathway_Homo sapiens_hsa043700.63212564
141Chemical carcinogenesis_Homo sapiens_hsa052040.61482691
142MAPK signaling pathway_Homo sapiens_hsa040100.61123717
143Metabolic pathways_Homo sapiens_hsa011000.60457264
144Nicotine addiction_Homo sapiens_hsa050330.60388529
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60221347
146Toxoplasmosis_Homo sapiens_hsa051450.59989130
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59894117
148Inositol phosphate metabolism_Homo sapiens_hsa005620.58613865
149Bile secretion_Homo sapiens_hsa049760.58496062
150Primary immunodeficiency_Homo sapiens_hsa053400.58428599
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57083434
152One carbon pool by folate_Homo sapiens_hsa006700.56795922
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56189957
154TGF-beta signaling pathway_Homo sapiens_hsa043500.55439497
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53568266
156Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53060605
157Taste transduction_Homo sapiens_hsa047420.52737721
158Circadian rhythm_Homo sapiens_hsa047100.52405601
159Osteoclast differentiation_Homo sapiens_hsa043800.52314698
160Rap1 signaling pathway_Homo sapiens_hsa040150.51769837
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50681752
162Renal cell carcinoma_Homo sapiens_hsa052110.49735279
163Arginine biosynthesis_Homo sapiens_hsa002200.49044894
164AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49017264
165Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48469484
166Hippo signaling pathway_Homo sapiens_hsa043900.48112902
167Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47980842
168Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47890437
169Steroid hormone biosynthesis_Homo sapiens_hsa001400.47606397
170Serotonergic synapse_Homo sapiens_hsa047260.46154660
171Spliceosome_Homo sapiens_hsa030400.45588196
172Arachidonic acid metabolism_Homo sapiens_hsa005900.43087361
1732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42084197
174Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41164498
175Sphingolipid metabolism_Homo sapiens_hsa006000.39585177
176Fat digestion and absorption_Homo sapiens_hsa049750.37518412
177Vitamin digestion and absorption_Homo sapiens_hsa049770.37500630
178Glycerolipid metabolism_Homo sapiens_hsa005610.37357763
179Type I diabetes mellitus_Homo sapiens_hsa049400.35357222
180Folate biosynthesis_Homo sapiens_hsa007900.35003510
181Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33553105
182N-Glycan biosynthesis_Homo sapiens_hsa005100.31180853
183Starch and sucrose metabolism_Homo sapiens_hsa005000.29909182

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