TLK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.49318937
2nuclear pore organization (GO:0006999)5.93834210
3regulation of posttranscriptional gene silencing (GO:0060147)5.93508112
4regulation of gene silencing by miRNA (GO:0060964)5.93508112
5regulation of gene silencing by RNA (GO:0060966)5.93508112
6mitotic sister chromatid cohesion (GO:0007064)5.13616745
7regulation of histone H3-K27 methylation (GO:0061085)5.07547290
8piRNA metabolic process (GO:0034587)4.87989157
9cilium or flagellum-dependent cell motility (GO:0001539)4.76443309
10pore complex assembly (GO:0046931)4.72006644
11regulation of DNA damage checkpoint (GO:2000001)4.71954509
12synaptonemal complex assembly (GO:0007130)4.67334382
13synaptonemal complex organization (GO:0070193)4.54018705
14regulation of RNA export from nucleus (GO:0046831)4.48628447
15male meiosis (GO:0007140)4.46748306
16monoubiquitinated protein deubiquitination (GO:0035520)4.32670118
17histone H4-K12 acetylation (GO:0043983)4.28731795
18negative regulation of gene silencing (GO:0060969)4.18538253
19regulation of centriole replication (GO:0046599)4.17524126
20positive regulation of keratinocyte differentiation (GO:0045618)4.17036083
21inner cell mass cell proliferation (GO:0001833)4.12555763
22regulation of histone H3-K9 methylation (GO:0051570)4.12435278
23acrosome assembly (GO:0001675)4.12098632
24negative regulation of DNA repair (GO:0045738)4.01298492
25microtubule depolymerization (GO:0007019)3.87849801
26macrophage activation involved in immune response (GO:0002281)3.84885893
27positive regulation of cell cycle G2/M phase transition (GO:1902751)3.81844421
28positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.81844421
29heterochromatin organization (GO:0070828)3.81829058
30fusion of sperm to egg plasma membrane (GO:0007342)3.81242865
31regulation of nucleobase-containing compound transport (GO:0032239)3.81158714
32pre-miRNA processing (GO:0031054)3.80697598
33positive regulation of mitotic sister chromatid separation (GO:1901970)3.77980934
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77980934
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77980934
36hepatocyte apoptotic process (GO:0097284)3.73565742
37regulation of protein polyubiquitination (GO:1902914)3.71795444
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71667465
39positive regulation of skeletal muscle tissue development (GO:0048643)3.63889329
40gene silencing by RNA (GO:0031047)3.62175753
41negative regulation of histone methylation (GO:0031061)3.60810451
42chromosome organization involved in meiosis (GO:0070192)3.60458585
43NLS-bearing protein import into nucleus (GO:0006607)3.56468258
44protein localization to chromosome, centromeric region (GO:0071459)3.53545321
45DNA methylation involved in gamete generation (GO:0043046)3.53397744
46sperm-egg recognition (GO:0035036)3.51192111
47chromatin assembly (GO:0031497)3.50682683
48intra-S DNA damage checkpoint (GO:0031573)3.46113520
49regulation of sister chromatid cohesion (GO:0007063)3.45607966
50sister chromatid cohesion (GO:0007062)3.44935150
51positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.44040152
52protein localization to kinetochore (GO:0034501)3.43852930
53regulation of establishment of cell polarity (GO:2000114)3.41623997
54cytoplasmic mRNA processing body assembly (GO:0033962)3.40711166
55spermatid development (GO:0007286)3.40591449
56mitotic nuclear envelope disassembly (GO:0007077)3.40074470
57sister chromatid segregation (GO:0000819)3.38435209
58regulation of mitotic spindle organization (GO:0060236)3.37875890
59positive regulation of chromosome segregation (GO:0051984)3.36412898
60mitotic chromosome condensation (GO:0007076)3.34905688
61DNA replication-dependent nucleosome assembly (GO:0006335)3.34722207
62DNA replication-dependent nucleosome organization (GO:0034723)3.34722207
63male meiosis I (GO:0007141)3.34074850
64mitotic metaphase plate congression (GO:0007080)3.33161645
65regulation of spindle organization (GO:0090224)3.32408657
66binding of sperm to zona pellucida (GO:0007339)3.30603318
67meiotic chromosome segregation (GO:0045132)3.29426611
68membrane disassembly (GO:0030397)3.26155410
69nuclear envelope disassembly (GO:0051081)3.26155410
70meiotic nuclear division (GO:0007126)3.24593685
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22386817
72microglial cell activation (GO:0001774)3.21517158
73positive regulation of protein import into nucleus, translocation (GO:0033160)3.19509503
74heart trabecula morphogenesis (GO:0061384)3.18296361
75histone H3-K36 demethylation (GO:0070544)3.17488331
76regulation of gene silencing (GO:0060968)3.17346589
77positive regulation of DNA-templated transcription, elongation (GO:0032786)3.16959293
78peptidyl-lysine dimethylation (GO:0018027)3.14546326
79regulation of cell cycle checkpoint (GO:1901976)3.14349462
80histone H3-K9 methylation (GO:0051567)3.13294595
81sperm motility (GO:0030317)3.12355755
82histone H2A monoubiquitination (GO:0035518)3.12340674
83cell-cell recognition (GO:0009988)3.11868998
84fatty acid elongation (GO:0030497)3.11682230
85histone H3-K9 demethylation (GO:0033169)3.11417081
86mitotic sister chromatid segregation (GO:0000070)3.08714354
87myoblast migration (GO:0051451)3.06737736
88regulation of centrosome cycle (GO:0046605)3.06225919
89meiotic cell cycle (GO:0051321)3.05806751
90spliceosomal tri-snRNP complex assembly (GO:0000244)3.05472644
91regulation of DNA endoreduplication (GO:0032875)3.05318905
92regulation of histone methylation (GO:0031060)3.04535507
93multicellular organism reproduction (GO:0032504)3.02777749
94protein K6-linked ubiquitination (GO:0085020)2.99774120
95interkinetic nuclear migration (GO:0022027)2.98852788
96phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.98385551
97cell wall macromolecule catabolic process (GO:0016998)2.96532157
98cell wall macromolecule metabolic process (GO:0044036)2.96532157
99regulation of meiosis I (GO:0060631)2.96162845
100negative regulation of striated muscle cell apoptotic process (GO:0010664)2.95916410
101histone H3-K4 trimethylation (GO:0080182)2.94551537
102peptidyl-threonine dephosphorylation (GO:0035970)2.93804476
103metaphase plate congression (GO:0051310)2.92854580
104gene silencing (GO:0016458)2.92444685
105peptidyl-lysine trimethylation (GO:0018023)2.91537265
106regulation of chromosome segregation (GO:0051983)2.91503042
107regulation of centrosome duplication (GO:0010824)2.90482557
108mitotic G2/M transition checkpoint (GO:0044818)2.90056510
109regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89450929
110positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.88877721
111chromosome condensation (GO:0030261)2.87463794
112meiotic cell cycle process (GO:1903046)2.87228899
113regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.86831360
114protein localization to chromosome (GO:0034502)2.86575886
115positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86412104
116embryonic process involved in female pregnancy (GO:0060136)2.85262305
117DNA methylation (GO:0006306)2.84333651
118DNA alkylation (GO:0006305)2.84333651
119DNA packaging (GO:0006323)2.84219919
120RNA stabilization (GO:0043489)2.83918389
121mRNA stabilization (GO:0048255)2.83918389
122regulation of establishment or maintenance of cell polarity (GO:0032878)2.83848321
123negative regulation of organelle assembly (GO:1902116)2.83333190
124negative regulation of keratinocyte proliferation (GO:0010839)2.81768278
125paraxial mesoderm development (GO:0048339)2.80647249
126negative regulation of neurotransmitter secretion (GO:0046929)2.80494994
127histone H3-K9 modification (GO:0061647)2.79622930
128kinetochore organization (GO:0051383)2.78055252
129cullin deneddylation (GO:0010388)2.77612808
130axonemal dynein complex assembly (GO:0070286)2.77293260
131regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74976789
132regulation of B cell receptor signaling pathway (GO:0050855)2.74685227
133meiosis I (GO:0007127)2.73902582
134chromatin assembly or disassembly (GO:0006333)2.73675812
135embryonic camera-type eye morphogenesis (GO:0048596)2.72042426
136regulation of helicase activity (GO:0051095)2.70758732
137DNA duplex unwinding (GO:0032508)2.70506370
138TOR signaling (GO:0031929)2.70436780
139histone exchange (GO:0043486)2.69940399
140negative regulation of histone modification (GO:0031057)2.69021232
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68808950
142seminiferous tubule development (GO:0072520)2.68560502
143nucleus organization (GO:0006997)2.68144841
144attachment of spindle microtubules to kinetochore (GO:0008608)2.67073734
145plasma membrane fusion (GO:0045026)2.66022891
146negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65165448
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64645346
148histone demethylation (GO:0016577)2.64413339
149establishment of chromosome localization (GO:0051303)2.64250124
150histone lysine demethylation (GO:0070076)2.63393728
151DNA geometric change (GO:0032392)2.61396750
152regulation of stem cell maintenance (GO:2000036)2.60413867
153trabecula morphogenesis (GO:0061383)2.60183354
154positive regulation of epidermal cell differentiation (GO:0045606)2.59625780
155positive regulation of cell cycle checkpoint (GO:1901978)2.59312525
156regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.57783909
157mitotic G2 DNA damage checkpoint (GO:0007095)2.56185372
158peptidyl-lysine methylation (GO:0018022)2.55829060
159snRNA transcription (GO:0009301)2.53586697
160positive regulation of histone methylation (GO:0031062)2.52633031
161cellular response to interferon-alpha (GO:0035457)2.52381051
162regulation of cell cycle G2/M phase transition (GO:1902749)2.52278599
163dosage compensation (GO:0007549)2.49757579
164mRNA transcription (GO:0009299)2.49672063
165regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.49125782
166mitotic DNA integrity checkpoint (GO:0044774)2.46262394
167DNA conformation change (GO:0071103)2.45049338
168positive regulation of mitotic cell cycle phase transition (GO:1901992)2.43405513
169establishment of protein localization to Golgi (GO:0072600)2.42192286
170skeletal muscle tissue regeneration (GO:0043403)2.41247952
171histone H3-K4 methylation (GO:0051568)2.40960374
172regulation of histone H3-K4 methylation (GO:0051569)2.39197439
173response to epidermal growth factor (GO:0070849)2.38290712
174regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.38205058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.91901439
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.77745821
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.54954037
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.40569159
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.11108032
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88120099
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.54079648
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98320068
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60028751
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.52824871
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25014275
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.23435415
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23354318
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.13486640
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11931182
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01625703
17AR_21909140_ChIP-Seq_LNCAP_Human2.00916332
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.97301267
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.87737287
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83593384
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79346852
22AHR_22903824_ChIP-Seq_MCF-7_Human1.76771281
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74801327
24FOXM1_26456572_ChIP-Seq_MCF-7_Human1.74523503
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.71917082
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68168417
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62977381
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.61674119
29NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60234344
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56782630
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56782630
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56782630
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55760033
34ER_23166858_ChIP-Seq_MCF-7_Human1.55033031
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53893649
36PKCTHETA_26484144_Chip-Seq_BREAST_Human1.51980729
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51134562
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49963982
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.46942217
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.45431148
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43534484
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43095562
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37677787
44GATA1_22025678_ChIP-Seq_K562_Human1.36587942
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36170205
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35185684
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33278520
48MYC_22102868_ChIP-Seq_BL_Human1.33089661
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29810164
50TP53_16413492_ChIP-PET_HCT116_Human1.29230554
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26812026
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26329267
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25464828
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24457985
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.22943775
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22786175
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20975716
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.20420289
59KDM5A_27292631_Chip-Seq_BREAST_Human1.20051210
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18948267
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17260781
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16240638
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16240638
64* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13318342
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.12492675
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10843762
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07289476
68TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07062739
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06189730
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05838297
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.05825783
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05319274
73TCF7_22412390_ChIP-Seq_EML_Mouse1.04368523
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04228349
75* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03396332
76CIITA_25753668_ChIP-Seq_RAJI_Human1.03326591
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02900463
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.01632433
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01286129
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00381724
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00138453
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99559860
83BRD4_25478319_ChIP-Seq_HGPS_Human0.99529530
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99002959
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99002834
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97895171
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.97862401
88* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97857708
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96818850
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96699582
91ELK1_19687146_ChIP-ChIP_HELA_Human0.96655551
92WT1_19549856_ChIP-ChIP_CCG9911_Human0.96494311
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95801496
94NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95635964
95GATA6_25053715_ChIP-Seq_YYC3_Human0.94256667
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94199297
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93948796
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93665533
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93525349
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92813643
101* CHD1_26751641_Chip-Seq_LNCaP_Human0.91570044
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89519691
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89229310
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89174744
105FUS_26573619_Chip-Seq_HEK293_Human0.87822968
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87485430
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87370811
108MYB_26560356_Chip-Seq_TH2_Human0.86885950
109EWS_26573619_Chip-Seq_HEK293_Human0.86590474
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85351959
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84605443
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84484018
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84061598
114* IRF8_27001747_Chip-Seq_BMDM_Mouse0.84043655
115TFEB_21752829_ChIP-Seq_HELA_Human0.82022565
116* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81875102
117* PU_27001747_Chip-Seq_BMDM_Mouse0.81717766
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81333810
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81283923
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81070107
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80960744
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79748823
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79248769
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78494245
125GF1B_26923725_Chip-Seq_HPCs_Mouse0.78472080
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78458863
127MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78215919
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77931950
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77149029
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76977806
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75845518
132XRN2_22483619_ChIP-Seq_HELA_Human0.74284067
133* UBF1/2_26484160_Chip-Seq_HMECs_Human0.74276456
134PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.73837793
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.72773308
136WDR5_24793694_ChIP-Seq_LNCAP_Human0.72738879
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72646183
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72232764
139SOX2_16153702_ChIP-ChIP_HESCs_Human0.71171621
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.71111681
141TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.70779478
142* MYB_26560356_Chip-Seq_TH1_Human0.70729530
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69996232
144NANOG_18692474_ChIP-Seq_MESCs_Mouse0.69203730
145KDM2B_26808549_Chip-Seq_DND41_Human0.69196745
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69086243
147TBX3_20139965_ChIP-Seq_MESCs_Mouse0.69048239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.52009269
2MP0005410_abnormal_fertilization3.20510220
3MP0010094_abnormal_chromosome_stability3.16379834
4MP0008057_abnormal_DNA_replication3.00720811
5MP0010307_abnormal_tumor_latency2.91153501
6MP0003111_abnormal_nucleus_morphology2.83870735
7MP0000569_abnormal_digit_pigmentation2.80198025
8MP0002009_preneoplasia2.66410081
9MP0003077_abnormal_cell_cycle2.64830859
10MP0005076_abnormal_cell_differentiation2.57495470
11MP0010352_gastrointestinal_tract_polyps2.56901291
12MP0005623_abnormal_meninges_morphology2.41941452
13MP0008260_abnormal_autophagy2.34936429
14MP0008007_abnormal_cellular_replicative2.31408486
15MP0003123_paternal_imprinting2.20678229
16MP0001929_abnormal_gametogenesis2.19500346
17MP0003705_abnormal_hypodermis_morpholog2.17163788
18MP0003693_abnormal_embryo_hatching2.14551656
19MP0004957_abnormal_blastocyst_morpholog2.11601241
20MP0008058_abnormal_DNA_repair2.08014313
21MP0002210_abnormal_sex_determination2.05874013
22MP0000383_abnormal_hair_follicle2.02697770
23MP0003121_genomic_imprinting1.90436766
24MP0001730_embryonic_growth_arrest1.89913747
25MP0003698_abnormal_male_reproductive1.89089516
26MP0000733_abnormal_muscle_development1.88379182
27MP0003787_abnormal_imprinting1.87368147
28MP0004197_abnormal_fetal_growth/weight/1.87280114
29MP0001293_anophthalmia1.85948753
30MP0004808_abnormal_hematopoietic_stem1.85683645
31MP0002084_abnormal_developmental_patter1.85165324
32MP0005380_embryogenesis_phenotype1.80887267
33MP0001672_abnormal_embryogenesis/_devel1.80887267
34MP0000350_abnormal_cell_proliferation1.78869314
35MP0010678_abnormal_skin_adnexa1.77359476
36MP0001145_abnormal_male_reproductive1.72440383
37MP0003984_embryonic_growth_retardation1.70571864
38MP0002088_abnormal_embryonic_growth/wei1.68090450
39MP0002086_abnormal_extraembryonic_tissu1.66820862
40MP0003690_abnormal_glial_cell1.66501870
41MP0001697_abnormal_embryo_size1.63756210
42MP0003183_abnormal_peptide_metabolism1.63694315
43MP0002085_abnormal_embryonic_tissue1.57721657
44MP0003890_abnormal_embryonic-extraembry1.51548582
45MP0000653_abnormal_sex_gland1.48526410
46MP0003937_abnormal_limbs/digits/tail_de1.47881644
47MP0005666_abnormal_adipose_tissue1.46909308
48MP0002653_abnormal_ependyma_morphology1.44825153
49MP0004264_abnormal_extraembryonic_tissu1.36959456
50MP0000428_abnormal_craniofacial_morphol1.36653223
51MP0002877_abnormal_melanocyte_morpholog1.35541181
52MP0003646_muscle_fatigue1.33333546
53MP0000537_abnormal_urethra_morphology1.31165217
54MP0003941_abnormal_skin_development1.28951256
55MP0002080_prenatal_lethality1.24562545
56MP0005451_abnormal_body_composition1.22622321
57MP0003950_abnormal_plasma_membrane1.21649828
58MP0008932_abnormal_embryonic_tissue1.21374002
59MP0009053_abnormal_anal_canal1.20828110
60MP0003221_abnormal_cardiomyocyte_apopto1.18193036
61MP0000750_abnormal_muscle_regeneration1.18039163
62MP0000432_abnormal_head_morphology1.17995620
63MP0003300_gastrointestinal_ulcer1.14645017
64MP0005248_abnormal_Harderian_gland1.12615549
65MP0003935_abnormal_craniofacial_develop1.11741883
66MP0003566_abnormal_cell_adhesion1.11647745
67MP0002161_abnormal_fertility/fecundity1.11508278
68MP0009278_abnormal_bone_marrow1.11101240
69MP0006082_CNS_inflammation1.10181629
70MP0004233_abnormal_muscle_weight1.09065684
71MP0003786_premature_aging1.08442342
72MP0002092_abnormal_eye_morphology1.07958895
73MP0009780_abnormal_chondrocyte_physiolo1.05039343
74MP0003567_abnormal_fetal_cardiomyocyte1.04792209
75MP0002925_abnormal_cardiovascular_devel1.04419523
76MP0003119_abnormal_digestive_system1.03501962
77MP0003453_abnormal_keratinocyte_physiol1.02985811
78MP0003091_abnormal_cell_migration1.01512134
79MP0009115_abnormal_fat_cell1.00278428
80MP0005375_adipose_tissue_phenotype0.99924813
81MP0003943_abnormal_hepatobiliary_system0.99902982
82MP0010234_abnormal_vibrissa_follicle0.99777306
83MP0002697_abnormal_eye_size0.99365165
84MP0000313_abnormal_cell_death0.97961159
85MP0003755_abnormal_palate_morphology0.97037080
86MP0003448_altered_tumor_morphology0.96286475
87MP0001849_ear_inflammation0.96227340
88MP0005367_renal/urinary_system_phenotyp0.92928054
89MP0000516_abnormal_urinary_system0.92928054
90MP0009703_decreased_birth_body0.92130297
91MP0001243_abnormal_dermal_layer0.91230475
92MP0003385_abnormal_body_wall0.91214155
93MP0010030_abnormal_orbit_morphology0.89385300
94MP0002127_abnormal_cardiovascular_syste0.89151154
95MP0003115_abnormal_respiratory_system0.87617623
96MP0002796_impaired_skin_barrier0.87195244
97MP0001299_abnormal_eye_distance/0.86981876
98MP0005187_abnormal_penis_morphology0.85344108
99MP0008961_abnormal_basal_metabolism0.84362065
100MP0003942_abnormal_urinary_system0.83292381
101MP0001915_intracranial_hemorrhage0.83218984
102MP0002019_abnormal_tumor_incidence0.82627251
103MP0001286_abnormal_eye_development0.81992075
104MP0004883_abnormal_blood_vessel0.81441672
105MP0002098_abnormal_vibrissa_morphology0.80881532
106MP0001216_abnormal_epidermal_layer0.80775553
107MP0003861_abnormal_nervous_system0.80328222
108MP0002396_abnormal_hematopoietic_system0.79616327
109MP0000377_abnormal_hair_follicle0.78587920
110MP0005397_hematopoietic_system_phenotyp0.77598899
111MP0001545_abnormal_hematopoietic_system0.77598899
112MP0004185_abnormal_adipocyte_glucose0.77021798
113MP0004272_abnormal_basement_membrane0.76923271
114MP0006292_abnormal_olfactory_placode0.76817411
115MP0010630_abnormal_cardiac_muscle0.76365573
116MP0002160_abnormal_reproductive_system0.75990197
117MP0004130_abnormal_muscle_cell0.75061254
118MP0005621_abnormal_cell_physiology0.74630392
119MP0006054_spinal_hemorrhage0.74336642
120MP0002269_muscular_atrophy0.72605923
121MP0005197_abnormal_uvea_morphology0.72216811
122MP0000266_abnormal_heart_morphology0.71587362
123MP0002282_abnormal_trachea_morphology0.70425103
124MP0003699_abnormal_female_reproductive0.70233366
125MP0001727_abnormal_embryo_implantation0.70019687
126MP0009672_abnormal_birth_weight0.69282290
127MP0005023_abnormal_wound_healing0.67757601
128MP0001784_abnormal_fluid_regulation0.66783902
129MP0003936_abnormal_reproductive_system0.66528952
130MP0000627_abnormal_mammary_gland0.65861919
131MP0000427_abnormal_hair_cycle0.65329751
132MP0000703_abnormal_thymus_morphology0.65321267
133MP0005391_vision/eye_phenotype0.65228874
134MP0008995_early_reproductive_senescence0.65189850
135MP0002116_abnormal_craniofacial_bone0.64937085

Predicted human phenotypes

RankGene SetZ-score
1Deep palmar crease (HP:0006191)4.37831002
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.16440260
3Curly hair (HP:0002212)3.93857236
4Asymmetry of the thorax (HP:0001555)3.59471539
5Absent/shortened dynein arms (HP:0200106)3.56409788
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.56409788
7Volvulus (HP:0002580)3.36128140
8Cystic hygroma (HP:0000476)2.83437472
9Embryonal renal neoplasm (HP:0011794)2.76153271
10Thyroid carcinoma (HP:0002890)2.75339801
11Papillary thyroid carcinoma (HP:0002895)2.72899323
12Abnormal respiratory motile cilium physiology (HP:0012261)2.70507215
13Sparse lateral eyebrow (HP:0005338)2.69665895
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.59361834
15Medulloblastoma (HP:0002885)2.58292307
16Hypoplastic ischia (HP:0003175)2.56210512
17Short 4th metacarpal (HP:0010044)2.47277356
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47277356
19Abnormality of the labia minora (HP:0012880)2.46260771
20Ectopic kidney (HP:0000086)2.44566825
21Abnormality of the fingertips (HP:0001211)2.44042935
22Absent frontal sinuses (HP:0002688)2.43726044
23Scotoma (HP:0000575)2.42350330
24Increased nuchal translucency (HP:0010880)2.41706943
25Leiomyosarcoma (HP:0100243)2.41637092
26Uterine leiomyosarcoma (HP:0002891)2.41637092
27Abnormality of the astrocytes (HP:0100707)2.40183782
28Astrocytoma (HP:0009592)2.40183782
29Transitional cell carcinoma of the bladder (HP:0006740)2.39828905
30Ependymoma (HP:0002888)2.38741289
31Cubitus valgus (HP:0002967)2.36158133
32Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.33654251
33Bladder neoplasm (HP:0009725)2.31018906
34Bladder carcinoma (HP:0002862)2.31018906
35Neoplasm of the oral cavity (HP:0100649)2.29791008
36Menstrual irregularities (HP:0000858)2.28849777
37Heterotopia (HP:0002282)2.27648984
38Chromsome breakage (HP:0040012)2.26818278
39Dysmetric saccades (HP:0000641)2.25001573
40Rhinitis (HP:0012384)2.24530851
41Neonatal hypoglycemia (HP:0001998)2.23523740
42Abnormal respiratory motile cilium morphology (HP:0005938)2.22774126
43Abnormal respiratory epithelium morphology (HP:0012253)2.22774126
44Abnormality of the antihelix (HP:0009738)2.22294878
45Abnormality of chromosome segregation (HP:0002916)2.21197543
46Glioma (HP:0009733)2.21082715
47Supernumerary spleens (HP:0009799)2.20886641
48Biliary tract neoplasm (HP:0100574)2.20230925
49Nasal polyposis (HP:0100582)2.19794600
50Supernumerary ribs (HP:0005815)2.19316739
51Selective tooth agenesis (HP:0001592)2.18388383
52Abnormality of the nasal septum (HP:0000419)2.15900356
53Elfin facies (HP:0004428)2.14046402
54Abnormality of the ischium (HP:0003174)2.13228463
55Abnormal ciliary motility (HP:0012262)2.10083738
56Prominent nose (HP:0000448)2.08932195
57Relative macrocephaly (HP:0004482)2.08254554
58Macroorchidism (HP:0000053)2.07665843
59Cafe-au-lait spot (HP:0000957)2.07102110
60Abnormality of the columella (HP:0009929)2.06058250
61Truncal obesity (HP:0001956)2.05375039
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04123791
63Absent eyebrow (HP:0002223)2.03700037
64Microglossia (HP:0000171)2.03637162
65Submucous cleft hard palate (HP:0000176)2.03302974
66Acute lymphatic leukemia (HP:0006721)2.03272074
67Impulsivity (HP:0100710)2.02875971
68Rhabdomyosarcoma (HP:0002859)2.02797166
69Hypopigmentation of the fundus (HP:0007894)2.02707468
70Broad thumb (HP:0011304)2.00126572
71Acute myeloid leukemia (HP:0004808)2.00054908
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.98624227
73Abnormal pancreas size (HP:0012094)1.97321983
74Abnormality of chromosome stability (HP:0003220)1.97215310
75Abnormality of the lower motor neuron (HP:0002366)1.96643575
76Thoracolumbar scoliosis (HP:0002944)1.96491715
77Oligodactyly (HP:0012165)1.94809088
78Deviation of the thumb (HP:0009603)1.93231792
79Thickened helices (HP:0000391)1.93083159
80Oligodactyly (hands) (HP:0001180)1.92934442
81Narrow palate (HP:0000189)1.92523115
82Long eyelashes (HP:0000527)1.91868167
83Diastasis recti (HP:0001540)1.91755460
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.90628625
85Supernumerary bones of the axial skeleton (HP:0009144)1.90015494
86Short chin (HP:0000331)1.88197237
87Neoplasm of striated muscle (HP:0009728)1.87029132
88Renovascular hypertension (HP:0100817)1.86954248
89Proximal placement of thumb (HP:0009623)1.86442616
90Hepatoblastoma (HP:0002884)1.85231864
91Myelodysplasia (HP:0002863)1.84188044
92Arteriovenous malformation (HP:0100026)1.83597929
93Renal cell carcinoma (HP:0005584)1.82963589
94Abnormality of the ileum (HP:0001549)1.82765392
95Nephronophthisis (HP:0000090)1.82655617
96Infertility (HP:0000789)1.82653346
97Urethral obstruction (HP:0000796)1.82525134
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82318310
99Cortical dysplasia (HP:0002539)1.82283483
100Overlapping toe (HP:0001845)1.82085440
101Abnormality of the phalanges of the hallux (HP:0010057)1.81094762
102Capillary hemangiomas (HP:0005306)1.80403590
103Colon cancer (HP:0003003)1.80235091
104Pulmonic stenosis (HP:0001642)1.79674896
105Dislocated radial head (HP:0003083)1.78470306
106Subaortic stenosis (HP:0001682)1.78267225
107Abnormality of the left ventricular outflow tract (HP:0011103)1.78267225
108Abnormality of the preputium (HP:0100587)1.78247229
109Chronic bronchitis (HP:0004469)1.78230499
110Abnormality of incisor morphology (HP:0011063)1.77732730
111Abnormality of the 4th metacarpal (HP:0010012)1.77186489
112Sandal gap (HP:0001852)1.76700691
113Midline defect of the nose (HP:0004122)1.75065475
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74929591
115Central scotoma (HP:0000603)1.74667146
116Rectal prolapse (HP:0002035)1.73585178
117Subacute progressive viral hepatitis (HP:0006572)1.73552025
118Sloping forehead (HP:0000340)1.73291134
119Broad phalanges of the hand (HP:0009768)1.72236924
120Short ribs (HP:0000773)1.70680505
121Cutaneous syndactyly (HP:0012725)1.70374159
122Renal duplication (HP:0000075)1.70347316
123Abnormality of the carotid arteries (HP:0005344)1.70263259
124Vertebral arch anomaly (HP:0008438)1.70171336
125Abnormality of the frontal sinuses (HP:0002687)1.69877769
126Malignant gastrointestinal tract tumors (HP:0006749)1.69642381
127Gastrointestinal carcinoma (HP:0002672)1.69642381
128Abnormal spermatogenesis (HP:0008669)1.69551362
129Long palpebral fissure (HP:0000637)1.68972978
130Genetic anticipation (HP:0003743)1.68635689
131Nephroblastoma (Wilms tumor) (HP:0002667)1.68494443
132Hyperacusis (HP:0010780)1.68393580
133Hypoplastic labia majora (HP:0000059)1.68325463
134Vitreoretinal degeneration (HP:0000655)1.68075692
135Hamartoma (HP:0010566)1.67940333
136Bronchitis (HP:0012387)1.66996050
137Duodenal stenosis (HP:0100867)1.66947991
138Small intestinal stenosis (HP:0012848)1.66947991
139Insidious onset (HP:0003587)1.66601590
140Termporal pattern (HP:0011008)1.66601590
141Abnormality of the parietal bone (HP:0002696)1.66502689
142Shallow orbits (HP:0000586)1.66066175
143Increased number of teeth (HP:0011069)1.65324517
144Meckel diverticulum (HP:0002245)1.65189497
145Abnormality of abdominal situs (HP:0011620)1.64192876
146Abdominal situs inversus (HP:0003363)1.64192876
147Embryonal neoplasm (HP:0002898)1.64096183
148Abnormality of the diencephalon (HP:0010662)1.63713526
149Facial hemangioma (HP:0000329)1.63566705
150Large earlobe (HP:0009748)1.63525001
151Low anterior hairline (HP:0000294)1.62690450
152Tubular atrophy (HP:0000092)1.62674779
153Spinal cord lesions (HP:0100561)1.62509382
154Syringomyelia (HP:0003396)1.62509382
155Abnormality of the radial head (HP:0003995)1.62214695
156Limited elbow extension (HP:0001377)1.61956965
157Germ cell neoplasia (HP:0100728)1.61863128
158Missing ribs (HP:0000921)1.61641501
159Deep philtrum (HP:0002002)1.60687625
160Abnormality of the aortic arch (HP:0012303)1.60277184
161Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.59739192
162Recurrent bronchitis (HP:0002837)1.59506417
163Abnormality of the epiphyses of the hand (HP:0005924)1.59472084
164Abnormality of the proximal phalanges of the hand (HP:0009834)1.59096232
165Abnormality of the distal phalanx of the thumb (HP:0009617)1.58445492
166Pelvic girdle muscle weakness (HP:0003749)1.58240793
167Short humerus (HP:0005792)1.58101816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.62316990
2AKT35.50024794
3IRAK44.07488091
4CDC73.84407087
5TAF13.33948388
6NEK23.27659071
7PDK43.07202798
8PDK33.07202798
9LATS12.85591702
10KSR12.40680583
11PRKD32.30251970
12SGK22.22789592
13STK32.17983965
14RPS6KA42.17100148
15BRD42.09391679
16TTK2.02623543
17BRAF2.02595357
18EPHA21.76810093
19TRIB31.72094344
20PDK21.68563898
21PIK3CA1.63365012
22ICK1.61247739
23ATR1.60737035
24MAP3K101.60409597
25WEE11.56433912
26CHEK21.56371129
27SRPK11.53810272
28PIK3CG1.53419611
29* CHEK11.52043572
30MAP2K31.51964770
31PNCK1.48891170
32CDK61.48462830
33RIPK11.42225372
34ATM1.41832680
35STK41.39056508
36CDK41.33411506
37ACVR1B1.32110468
38DYRK31.32023223
39PKN21.27653350
40MTOR1.26701985
41TYRO31.25640964
42CDK91.25117182
43ILK1.24366594
44STK391.23298961
45PLK11.22973700
46EEF2K1.20866280
47STK38L1.20367523
48SGK4941.18867326
49SGK2231.18867326
50ALK1.18504933
51MKNK21.15758737
52NEK61.13925758
53AURKB1.12996526
54CDK71.10040092
55TTN1.06325949
56PLK31.05604954
57BRSK21.04169059
58STK101.02838275
59CAMK1D0.96422114
60YES10.96005472
61MAP3K140.95987437
62PDGFRB0.95828367
63LATS20.95464427
64FGFR40.94365483
65CAMK1G0.93988721
66NLK0.92890042
67PTK20.89272575
68IRAK10.88481955
69* CDK20.86940158
70PLK40.86382889
71NEK90.84260937
72PRKD20.83453800
73PDGFRA0.82377677
74PASK0.82247322
75PIM10.82181733
76DDR20.81279585
77MKNK10.80966353
78PRPF4B0.79931182
79MARK30.79873909
80MELK0.78613986
81EIF2AK30.77389636
82IRAK20.77290092
83RPS6KB20.77038023
84DMPK0.75310941
85SCYL20.74955202
86CDK10.72979943
87CSNK1D0.72324037
88NUAK10.72097798
89MAP3K80.70748371
90PRKDC0.65247012
91MAP2K40.65111514
92BMX0.63864417
93CHUK0.63688239
94STK380.61845891
95BUB10.60957510
96WNK10.60873198
97FGFR10.59705208
98RPS6KA50.58103322
99HIPK20.57981271
100PRKCI0.56737731
101STK240.56451201
102FGFR30.55198743
103TLK10.55141271
104FLT30.55093501
105FGFR20.54596744
106MAPK100.54524241
107PTK60.54179301
108MET0.54172946
109MAP3K20.53565829
110TESK10.53382161
111ERBB30.52706428
112RET0.51699276
113SIK10.51334528
114MAP3K90.50641425
115IKBKE0.50258088
116MAPK140.50209229
117WNK40.46825003
118ERN10.46173156
119SGK30.44599888
120CSNK1E0.43948483
121CAMK40.43797293
122PBK0.43660091
123MAP2K10.43469810
124JAK30.43170870
125IRAK30.42819925
126* GSK3B0.41376303
127PAK20.41374696
128MAPK10.41337139
129MAP3K40.41254123
130SGK10.40642888
131AKT10.40096141
132NEK10.39479109
133PTK2B0.38382555
134MAP3K130.36241906
135MAP3K50.34552356
136STK110.34256844
137RPS6KB10.32593916
138ZAK0.32503864
139AKT20.31300981
140BCR0.28943213
141CSNK2A20.28683454
142* MAPK80.27813324

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.49434126
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44250570
3Cell cycle_Homo sapiens_hsa041102.36583468
4mRNA surveillance pathway_Homo sapiens_hsa030152.35007834
5Basal transcription factors_Homo sapiens_hsa030222.22694792
6Fanconi anemia pathway_Homo sapiens_hsa034602.04108354
7Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.90336483
8Dorso-ventral axis formation_Homo sapiens_hsa043201.83002920
9Spliceosome_Homo sapiens_hsa030401.79103357
10Systemic lupus erythematosus_Homo sapiens_hsa053221.68201613
11MicroRNAs in cancer_Homo sapiens_hsa052061.59297690
12Mismatch repair_Homo sapiens_hsa034301.58622449
13RNA degradation_Homo sapiens_hsa030181.53631458
14Oocyte meiosis_Homo sapiens_hsa041141.52164255
15Herpes simplex infection_Homo sapiens_hsa051681.48311152
16Non-homologous end-joining_Homo sapiens_hsa034501.47235742
17Viral carcinogenesis_Homo sapiens_hsa052031.44659062
18p53 signaling pathway_Homo sapiens_hsa041151.42809751
19Adherens junction_Homo sapiens_hsa045201.41809884
20mTOR signaling pathway_Homo sapiens_hsa041501.40655851
21Hepatitis C_Homo sapiens_hsa051601.40009648
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39054678
23DNA replication_Homo sapiens_hsa030301.37133721
24One carbon pool by folate_Homo sapiens_hsa006701.37131902
25Small cell lung cancer_Homo sapiens_hsa052221.36184710
26Hippo signaling pathway_Homo sapiens_hsa043901.35777397
27Basal cell carcinoma_Homo sapiens_hsa052171.33866504
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32155181
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29197505
30Homologous recombination_Homo sapiens_hsa034401.28554977
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25849112
32HTLV-I infection_Homo sapiens_hsa051661.24268788
33Hedgehog signaling pathway_Homo sapiens_hsa043401.21771399
34Lysine degradation_Homo sapiens_hsa003101.21609981
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20336068
36Viral myocarditis_Homo sapiens_hsa054161.18358286
37TGF-beta signaling pathway_Homo sapiens_hsa043501.18052714
38Nucleotide excision repair_Homo sapiens_hsa034201.12935440
39Antigen processing and presentation_Homo sapiens_hsa046121.11816410
40Chronic myeloid leukemia_Homo sapiens_hsa052201.11767682
41Type II diabetes mellitus_Homo sapiens_hsa049301.10621595
42Insulin signaling pathway_Homo sapiens_hsa049101.09581539
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.08386108
44VEGF signaling pathway_Homo sapiens_hsa043701.06600920
45Proteoglycans in cancer_Homo sapiens_hsa052051.05083037
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05028467
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04016873
48Prostate cancer_Homo sapiens_hsa052151.03359076
49Measles_Homo sapiens_hsa051621.02697081
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02463635
51Influenza A_Homo sapiens_hsa051641.00749232
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.96769515
53Epstein-Barr virus infection_Homo sapiens_hsa051690.96125905
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95078480
55Base excision repair_Homo sapiens_hsa034100.90685268
56Wnt signaling pathway_Homo sapiens_hsa043100.90238002
57TNF signaling pathway_Homo sapiens_hsa046680.89874560
58Notch signaling pathway_Homo sapiens_hsa043300.87502735
59Chemokine signaling pathway_Homo sapiens_hsa040620.86993746
60FoxO signaling pathway_Homo sapiens_hsa040680.86922289
61ECM-receptor interaction_Homo sapiens_hsa045120.86767233
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86374123
63Legionellosis_Homo sapiens_hsa051340.86024205
64Colorectal cancer_Homo sapiens_hsa052100.85005795
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84752080
66Pancreatic cancer_Homo sapiens_hsa052120.84686257
67Focal adhesion_Homo sapiens_hsa045100.83751877
68Choline metabolism in cancer_Homo sapiens_hsa052310.83051969
69Endometrial cancer_Homo sapiens_hsa052130.82873555
70Estrogen signaling pathway_Homo sapiens_hsa049150.82777123
71Toxoplasmosis_Homo sapiens_hsa051450.80966396
72Allograft rejection_Homo sapiens_hsa053300.80965265
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79844210
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79358013
75Pathways in cancer_Homo sapiens_hsa052000.79334411
76Glucagon signaling pathway_Homo sapiens_hsa049220.79208746
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78883374
78Alcoholism_Homo sapiens_hsa050340.78496027
79Tight junction_Homo sapiens_hsa045300.78469459
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76266892
81Hepatitis B_Homo sapiens_hsa051610.76011513
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.74813923
83Renal cell carcinoma_Homo sapiens_hsa052110.74555323
84AMPK signaling pathway_Homo sapiens_hsa041520.73869178
85HIF-1 signaling pathway_Homo sapiens_hsa040660.72741465
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71171280
87Type I diabetes mellitus_Homo sapiens_hsa049400.69085674
88Apoptosis_Homo sapiens_hsa042100.67840053
89Platelet activation_Homo sapiens_hsa046110.67667477
90Acute myeloid leukemia_Homo sapiens_hsa052210.67502504
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67454638
92Long-term potentiation_Homo sapiens_hsa047200.66460028
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66399700
94Prolactin signaling pathway_Homo sapiens_hsa049170.66354458
95Circadian rhythm_Homo sapiens_hsa047100.65993370
96Thyroid cancer_Homo sapiens_hsa052160.65907261
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64197571
98Selenocompound metabolism_Homo sapiens_hsa004500.62536733
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62451709
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62426405
101Glioma_Homo sapiens_hsa052140.62363822
102Melanoma_Homo sapiens_hsa052180.61722867
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.61380796
104Graft-versus-host disease_Homo sapiens_hsa053320.60807147
105Tuberculosis_Homo sapiens_hsa051520.59530064
106Non-small cell lung cancer_Homo sapiens_hsa052230.59398917
107Insulin resistance_Homo sapiens_hsa049310.58290815
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58116020
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.57973279
110ErbB signaling pathway_Homo sapiens_hsa040120.57562868
111Osteoclast differentiation_Homo sapiens_hsa043800.56506185
112T cell receptor signaling pathway_Homo sapiens_hsa046600.56224502
113MAPK signaling pathway_Homo sapiens_hsa040100.54346274
114B cell receptor signaling pathway_Homo sapiens_hsa046620.53905345
115Bladder cancer_Homo sapiens_hsa052190.53732902
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.53463518
117Rap1 signaling pathway_Homo sapiens_hsa040150.52584363
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.51258309
119Leishmaniasis_Homo sapiens_hsa051400.49960312
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.49765528
121Inositol phosphate metabolism_Homo sapiens_hsa005620.49492911

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