ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adaptation of signaling pathway (GO:0023058)	5.69834509
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.60698450
3	viral transcription (GO:0019083)	5.18581601
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.14185605
5	ATP synthesis coupled proton transport (GO:0015986)	5.14185605
6	translational termination (GO:0006415)	5.05677921
7	otic vesicle formation (GO:0030916)	4.99261774
8	behavioral response to nicotine (GO:0035095)	4.72312210
9	neuron fate determination (GO:0048664)	4.68145370
10	cotranslational protein targeting to membrane (GO:0006613)	4.32297405
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.30758961
12	protein targeting to ER (GO:0045047)	4.25305058
13	ribosomal small subunit assembly (GO:0000028)	4.25021712
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.23088658
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.07098114
16	sequestering of actin monomers (GO:0042989)	4.01047092
17	translational elongation (GO:0006414)	3.99168968
18	protein localization to endoplasmic reticulum (GO:0070972)	3.94756928
19	cellular protein complex disassembly (GO:0043624)	3.92579037
20	respiratory electron transport chain (GO:0022904)	3.83494078
21	nonmotile primary cilium assembly (GO:0035058)	3.77467648
22	protein neddylation (GO:0045116)	3.73981500
23	electron transport chain (GO:0022900)	3.73932967
24	viral life cycle (GO:0019058)	3.70198400
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.56737600
26	protein-cofactor linkage (GO:0018065)	3.55546735
27	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.49852233
28	maturation of SSU-rRNA (GO:0030490)	3.44286351
29	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.44250275
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.40558817
31	midbrain development (GO:0030901)	3.35498772
32	translational initiation (GO:0006413)	3.26713715
33	protein localization to cilium (GO:0061512)	3.26563311
34	dopamine biosynthetic process (GO:0042416)	3.23430525
35	protein complex disassembly (GO:0043241)	3.20080275
36	serotonin metabolic process (GO:0042428)	3.19921702
37	negative regulation of inclusion body assembly (GO:0090084)	3.10847078
38	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	3.10645300
39	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	3.10645300
40	intraciliary transport (GO:0042073)	3.09191988
41	mechanosensory behavior (GO:0007638)	3.08590341
42	spinal cord association neuron differentiation (GO:0021527)	3.08511020
43	presynaptic membrane assembly (GO:0097105)	3.06513642
44	nephron tubule morphogenesis (GO:0072078)	3.05965973
45	nephron epithelium morphogenesis (GO:0072088)	3.05965973
46	hydrogen ion transmembrane transport (GO:1902600)	3.01278253
47	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.98031201
48	macromolecular complex disassembly (GO:0032984)	2.96108866
49	pyrimidine nucleobase catabolic process (GO:0006208)	2.90288351
50	protein complex biogenesis (GO:0070271)	2.88917680
51	hematopoietic stem cell proliferation (GO:0071425)	2.88209880
52	presynaptic membrane organization (GO:0097090)	2.87955944
53	primary amino compound metabolic process (GO:1901160)	2.86649829
54	chaperone-mediated protein transport (GO:0072321)	2.86154593
55	protein targeting to membrane (GO:0006612)	2.82699770
56	epithelial cilium movement (GO:0003351)	2.82451232
57	ribosomal large subunit biogenesis (GO:0042273)	2.73756608
58	transmission of nerve impulse (GO:0019226)	2.73615227
59	response to insecticide (GO:0017085)	2.73393276
60	dendritic spine morphogenesis (GO:0060997)	2.72841373
61	regulation of cilium movement (GO:0003352)	2.71512313
62	single strand break repair (GO:0000012)	2.70217091
63	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.66516289
64	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.66516289
65	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.66464926
66	somite development (GO:0061053)	2.63280442
67	proton transport (GO:0015992)	2.61703731
68	positive regulation of mRNA processing (GO:0050685)	2.60493627
69	viral mRNA export from host cell nucleus (GO:0046784)	2.59202464
70	hydrogen transport (GO:0006818)	2.58364921
71	regulation of dopamine metabolic process (GO:0042053)	2.58288958
72	regulation of catecholamine metabolic process (GO:0042069)	2.58288958
73	ATP biosynthetic process (GO:0006754)	2.56650940
74	Sertoli cell development (GO:0060009)	2.56386563
75	limb bud formation (GO:0060174)	2.55864259
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.55359994
77	NADH dehydrogenase complex assembly (GO:0010257)	2.55359994
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.55359994
79	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.53321805
80	neuronal action potential propagation (GO:0019227)	2.53317336
81	termination of RNA polymerase III transcription (GO:0006386)	2.52047347
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.52047347
83	neuron cell-cell adhesion (GO:0007158)	2.50886162
84	protein localization to synapse (GO:0035418)	2.50022039
85	positive regulation of gastrulation (GO:2000543)	2.49524677
86	mRNA catabolic process (GO:0006402)	2.49505568
87	axonal fasciculation (GO:0007413)	2.46787637
88	urogenital system development (GO:0001655)	2.45357649
89	startle response (GO:0001964)	2.43930283
90	synaptic transmission, cholinergic (GO:0007271)	2.43484159
91	eye photoreceptor cell differentiation (GO:0001754)	2.42631857
92	photoreceptor cell differentiation (GO:0046530)	2.42631857
93	postsynaptic membrane organization (GO:0001941)	2.42495395
94	neuronal stem cell maintenance (GO:0097150)	2.41243172
95	ribosomal small subunit biogenesis (GO:0042274)	2.40404775
96	retinal ganglion cell axon guidance (GO:0031290)	2.40099285
97	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.39307442
98	artery development (GO:0060840)	2.38636697
99	DNA deamination (GO:0045006)	2.37691941
100	forebrain neuron differentiation (GO:0021879)	2.36561664

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.16534216
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.59382939
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.20749880
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.75796329
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73726994
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.72936823
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71051806
8	VDR_22108803_ChIP-Seq_LS180_Human	2.66814075
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.52543775
10	FUS_26573619_Chip-Seq_HEK293_Human	2.45969134
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.41643500
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37042144
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35087989
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.28072655
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26813462
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26303284
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.25217686
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.23965885
19	EWS_26573619_Chip-Seq_HEK293_Human	2.15359239
20	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.11045147
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08318951
22	P300_19829295_ChIP-Seq_ESCs_Human	2.00294355
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93290793
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.89629562
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.88438132
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85976863
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.83409413
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81261503
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79574343
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.74043443
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.68936455
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67566262
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.62727513
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58966971
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.56367982
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.54841684
37	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.51152961
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49161774
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.47382282
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.46448782
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46301309
42	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.43569110
43	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.41857323
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39371615
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37166882
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36901616
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.35503266
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34601682
49	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34177310
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33760541
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33760541
52	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.32619023
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32180159
54	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.31949252
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.31794985
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31312945
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.30945961
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29860604
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29804561
60	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.28020171
61	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.27984995
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.26407939
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23298469
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.22952387
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22570216
66	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.22370749
67	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22369689
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.20242629
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.20015582
70	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.15726058
71	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.15726058
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15597171
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12837471
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12257929
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11485055
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11293542
77	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.10443874
78	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09628687
79	TP53_22573176_ChIP-Seq_HFKS_Human	1.09094873
80	STAT3_23295773_ChIP-Seq_U87_Human	1.08659298
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07755134
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07248048
83	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06221309
84	AR_25329375_ChIP-Seq_VCAP_Human	1.06135050
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05229770
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04998875
87	MYC_18940864_ChIP-ChIP_HL60_Human	1.04542498
88	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.02827962
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01945894
90	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01713368
91	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.00781651
92	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00429028
93	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00224461
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99745687
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99745687
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98210522
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98103118
98	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.97667318
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.97557128
100	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97557128

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.66149413
2	MP0006292_abnormal_olfactory_placode	3.63417700
3	MP0003136_yellow_coat_color	3.53515089
4	MP0003880_abnormal_central_pattern	3.12329890
5	MP0003878_abnormal_ear_physiology	2.97845375
6	MP0005377_hearing/vestibular/ear_phenot	2.97845375
7	MP0000566_synostosis	2.85314197
8	MP0003787_abnormal_imprinting	2.51631403
9	MP0001485_abnormal_pinna_reflex	2.36461776
10	MP0008877_abnormal_DNA_methylation	2.28321093
11	MP0005423_abnormal_somatic_nervous	2.11244328
12	MP0002163_abnormal_gland_morphology	2.09745424
13	MP0003122_maternal_imprinting	2.07697333
14	MP0002938_white_spotting	2.05225751
15	MP0004142_abnormal_muscle_tone	2.04506059
16	MP0000631_abnormal_neuroendocrine_gland	1.97039518
17	MP0001529_abnormal_vocalization	1.96038081
18	MP0002102_abnormal_ear_morphology	1.91049175
19	MP0005084_abnormal_gallbladder_morpholo	1.87915593
20	MP0001293_anophthalmia	1.85797836
21	MP0003938_abnormal_ear_development	1.85245246
22	MP0005645_abnormal_hypothalamus_physiol	1.83812154
23	MP0005646_abnormal_pituitary_gland	1.82880659
24	MP0004742_abnormal_vestibular_system	1.80961375
25	MP0000049_abnormal_middle_ear	1.75662313
26	MP0003283_abnormal_digestive_organ	1.75581205
27	MP0001486_abnormal_startle_reflex	1.75219641
28	MP0003011_delayed_dark_adaptation	1.71276935
29	MP0000569_abnormal_digit_pigmentation	1.67364514
30	MP0004885_abnormal_endolymph	1.66131146
31	MP0000778_abnormal_nervous_system	1.65079926
32	MP0002272_abnormal_nervous_system	1.62455181
33	MP0008789_abnormal_olfactory_epithelium	1.59897366
34	MP0005171_absent_coat_pigmentation	1.58982274
35	MP0005551_abnormal_eye_electrophysiolog	1.58683285
36	MP0003121_genomic_imprinting	1.57936120
37	MP0009745_abnormal_behavioral_response	1.57798156
38	MP0010030_abnormal_orbit_morphology	1.57791930
39	MP0004133_heterotaxia	1.46073779
40	MP0001968_abnormal_touch/_nociception	1.43889380
41	MP0008995_early_reproductive_senescence	1.41836818
42	MP0009046_muscle_twitch	1.40564425
43	MP0000026_abnormal_inner_ear	1.38911927
44	MP0006072_abnormal_retinal_apoptosis	1.38383328
45	MP0002928_abnormal_bile_duct	1.33804871
46	MP0005499_abnormal_olfactory_system	1.31923131
47	MP0005394_taste/olfaction_phenotype	1.31923131
48	MP0005379_endocrine/exocrine_gland_phen	1.30270172
49	MP0001905_abnormal_dopamine_level	1.28432389
50	MP0010386_abnormal_urinary_bladder	1.28234369
51	MP0002277_abnormal_respiratory_mucosa	1.27538789
52	MP0003937_abnormal_limbs/digits/tail_de	1.24997455
53	MP0001440_abnormal_grooming_behavior	1.24068901
54	MP0002572_abnormal_emotion/affect_behav	1.23041488
55	MP0002653_abnormal_ependyma_morphology	1.22915429
56	MP0002557_abnormal_social/conspecific_i	1.18940377
57	MP0002067_abnormal_sensory_capabilities	1.18895153
58	MP0002064_seizures	1.18286921
59	MP0001984_abnormal_olfaction	1.18223330
60	MP0002736_abnormal_nociception_after	1.17287862
61	MP0003635_abnormal_synaptic_transmissio	1.17067722
62	MP0006276_abnormal_autonomic_nervous	1.15041130
63	MP0003137_abnormal_impulse_conducting	1.14224775
64	MP0002638_abnormal_pupillary_reflex	1.12259322
65	MP0002234_abnormal_pharynx_morphology	1.11550567
66	MP0002249_abnormal_larynx_morphology	1.10379058
67	MP0002063_abnormal_learning/memory/cond	1.09375982
68	MP0005253_abnormal_eye_physiology	1.07720918
69	MP0002184_abnormal_innervation	1.05922989
70	MP0002160_abnormal_reproductive_system	1.04786355
71	MP0001286_abnormal_eye_development	1.03961075
72	MP0002752_abnormal_somatic_nervous	1.02764822
73	MP0005187_abnormal_penis_morphology	1.01620854
74	MP0003195_calcinosis	0.99388133
75	MP0004215_abnormal_myocardial_fiber	0.99255996
76	MP0003183_abnormal_peptide_metabolism	0.96148763
77	MP0002837_dystrophic_cardiac_calcinosis	0.96010725
78	MP0001963_abnormal_hearing_physiology	0.94187474
79	MP0001188_hyperpigmentation	0.93511437
80	MP0002734_abnormal_mechanical_nocicepti	0.93428817
81	MP0000372_irregular_coat_pigmentation	0.92931586
82	MP0003567_abnormal_fetal_cardiomyocyte	0.92854276
83	MP0003890_abnormal_embryonic-extraembry	0.88751039
84	MP0005360_urolithiasis	0.86429440
85	MP0005391_vision/eye_phenotype	0.86363917
86	MP0008872_abnormal_physiological_respon	0.85764077
87	MP0005195_abnormal_posterior_eye	0.85332726
88	MP0002697_abnormal_eye_size	0.85109008
89	MP0005248_abnormal_Harderian_gland	0.84304993
90	MP0004859_abnormal_synaptic_plasticity	0.83497063
91	MP0000955_abnormal_spinal_cord	0.83024076
92	MP0002233_abnormal_nose_morphology	0.82556151
93	MP0002095_abnormal_skin_pigmentation	0.81983910
94	MP0004924_abnormal_behavior	0.80521731
95	MP0005386_behavior/neurological_phenoty	0.80521731
96	MP0002751_abnormal_autonomic_nervous	0.79819932
97	MP0002282_abnormal_trachea_morphology	0.78284073
98	MP0002152_abnormal_brain_morphology	0.75401793
99	MP0002882_abnormal_neuron_morphology	0.74915460
100	MP0000647_abnormal_sebaceous_gland	0.74565884

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	4.81784450
2	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.24900672
3	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.24900672
4	Hypothermia (HP:0002045)	3.72824812
5	Abnormality of the corticospinal tract (HP:0002492)	3.45492929
6	Medial flaring of the eyebrow (HP:0010747)	3.38393842
7	Focal motor seizures (HP:0011153)	3.34075093
8	Abnormality of the labia minora (HP:0012880)	3.30901801
9	Abnormal number of erythroid precursors (HP:0012131)	3.23211192
10	Acute necrotizing encephalopathy (HP:0006965)	3.14359863
11	Increased hepatocellular lipid droplets (HP:0006565)	3.14034344
12	Mitochondrial inheritance (HP:0001427)	3.11572148
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.07519451
14	Absent septum pellucidum (HP:0001331)	2.98707971
15	Maternal diabetes (HP:0009800)	2.97148394
16	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.96598473
17	Congenital, generalized hypertrichosis (HP:0004540)	2.95239251
18	Hepatic necrosis (HP:0002605)	2.94323822
19	Oligodactyly (hands) (HP:0001180)	2.89117354
20	Optic nerve hypoplasia (HP:0000609)	2.88605603
21	Hepatocellular necrosis (HP:0001404)	2.86067211
22	Limb dystonia (HP:0002451)	2.84693440
23	Intestinal atresia (HP:0011100)	2.83837482
24	True hermaphroditism (HP:0010459)	2.82649790
25	Reticulocytopenia (HP:0001896)	2.77311613
26	3-Methylglutaconic aciduria (HP:0003535)	2.75118468
27	Nephrogenic diabetes insipidus (HP:0009806)	2.73582396
28	Myokymia (HP:0002411)	2.73347829
29	Pancreatic fibrosis (HP:0100732)	2.69546772
30	Pendular nystagmus (HP:0012043)	2.64109705
31	Bilateral microphthalmos (HP:0007633)	2.63667413
32	Progressive macrocephaly (HP:0004481)	2.61082086
33	Renal Fanconi syndrome (HP:0001994)	2.60050337
34	Gait imbalance (HP:0002141)	2.60022287
35	Lipid accumulation in hepatocytes (HP:0006561)	2.58076805
36	Gastrointestinal atresia (HP:0002589)	2.55448470
37	Increased CSF lactate (HP:0002490)	2.54308347
38	Generalized aminoaciduria (HP:0002909)	2.53346323
39	Genital tract atresia (HP:0001827)	2.53344404
40	Congenital primary aphakia (HP:0007707)	2.52924360
41	Carpal bone hypoplasia (HP:0001498)	2.52865993
42	Vaginal atresia (HP:0000148)	2.47444261
43	Acute encephalopathy (HP:0006846)	2.46366272
44	Pancreatic cysts (HP:0001737)	2.43995571
45	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.42538363
46	Hypoplasia of the fovea (HP:0007750)	2.42538363
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42073831
48	Colon cancer (HP:0003003)	2.41336670
49	Macrocytic anemia (HP:0001972)	2.39217063
50	Abnormality of the septum pellucidum (HP:0007375)	2.38479400
51	Abnormality of midbrain morphology (HP:0002418)	2.37629920
52	Molar tooth sign on MRI (HP:0002419)	2.37629920
53	Oligodactyly (HP:0012165)	2.33957499
54	Humeroradial synostosis (HP:0003041)	2.27273951
55	Synostosis involving the elbow (HP:0003938)	2.27273951
56	Renal cortical cysts (HP:0000803)	2.25783566
57	Exertional dyspnea (HP:0002875)	2.19397688
58	Type II lissencephaly (HP:0007260)	2.17518026
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.17377975
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.17377975
61	Abnormality of the fovea (HP:0000493)	2.17232449
62	Abnormal ciliary motility (HP:0012262)	2.16662846
63	Specific learning disability (HP:0001328)	2.14687021
64	Esophageal atresia (HP:0002032)	2.14348748
65	Growth hormone deficiency (HP:0000824)	2.13529817
66	Lissencephaly (HP:0001339)	2.04401701
67	Optic disc pallor (HP:0000543)	2.02706497
68	Nephronophthisis (HP:0000090)	2.00839350
69	Abnormal number of incisors (HP:0011064)	2.00479226
70	Morphological abnormality of the pyramidal tract (HP:0002062)	1.98309441
71	Febrile seizures (HP:0002373)	1.96460225
72	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.92036927
73	Poor coordination (HP:0002370)	1.90699534
74	Impaired vibration sensation in the lower limbs (HP:0002166)	1.87959943
75	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87729101
76	Sleep apnea (HP:0010535)	1.85741081
77	Retinal dysplasia (HP:0007973)	1.84953501
78	Cerebral edema (HP:0002181)	1.82412535
79	Concave nail (HP:0001598)	1.81268768
80	Abnormality of the middle phalanges of the toes (HP:0010183)	1.80216363
81	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76757905
82	Poor suck (HP:0002033)	1.76039994
83	Broad-based gait (HP:0002136)	1.74960475
84	Broad foot (HP:0001769)	1.74960352
85	Volvulus (HP:0002580)	1.73404583
86	Breast aplasia (HP:0100783)	1.73044257
87	Abnormality of renal resorption (HP:0011038)	1.72511869
88	Abnormality of the pons (HP:0007361)	1.72098547
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71551389
90	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.71318744
91	Decreased central vision (HP:0007663)	1.70858294
92	Abolished electroretinogram (ERG) (HP:0000550)	1.70681832
93	Sclerocornea (HP:0000647)	1.69353039
94	Anophthalmia (HP:0000528)	1.68457188
95	Abnormality of the renal medulla (HP:0100957)	1.67035859
96	Short hallux (HP:0010109)	1.65260967
97	Polyphagia (HP:0002591)	1.64868629
98	Broad alveolar ridges (HP:0000187)	1.63823005
99	Supernumerary spleens (HP:0009799)	1.63029330
100	Male pseudohermaphroditism (HP:0000037)	1.63024518

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.49177781
2	MAPK15	3.25673525
3	TNIK	3.02911363
4	CASK	2.98348801
5	BUB1	2.85967323
6	TSSK6	2.59523472
7	BMPR1B	2.43378350
8	STK16	2.33816728
9	MARK1	2.25360704
10	WNK3	2.24818721
11	VRK1	2.07641835
12	EPHA4	2.01070325
13	PASK	1.79872715
14	INSRR	1.76283747
15	DYRK3	1.75524451
16	NTRK2	1.68192958
17	VRK2	1.62576189
18	CDK19	1.46808557
19	DYRK2	1.39457395
20	PRKCG	1.39439755
21	ADRBK2	1.37736797
22	TGFBR1	1.34747163
23	UHMK1	1.34488398
24	WNK4	1.32930355
25	FRK	1.29724511
26	ZAK	1.28542693
27	MAP3K12	1.28531016
28	TLK1	1.28395592
29	OXSR1	1.24122852
30	MKNK2	1.19463131
31	MAPKAPK5	1.17514791
32	NTRK3	1.14946575
33	PINK1	1.13728456
34	WEE1	1.13671893
35	NLK	1.13626015
36	MAPK13	1.10842524
37	NME1	1.09934356
38	NUAK1	1.05849556
39	ACVR1B	1.05818089
40	GRK1	1.01459831
41	CAMKK2	0.99190089
42	PAK3	0.94139833
43	CDK8	0.93664708
44	MAP4K2	0.91701407
45	EPHB2	0.91142701
46	STK39	0.90509711
47	PRKCE	0.88007980
48	KSR1	0.87492671
49	MKNK1	0.84500821
50	TAOK3	0.84494822
51	PLK3	0.82875159
52	BCR	0.82807838
53	MAP2K4	0.82601223
54	MAP3K4	0.81765674
55	CSNK1G2	0.79571315
56	MINK1	0.79285200
57	SGK2	0.78398824
58	IRAK2	0.75592093
59	CAMK1	0.73307087
60	SGK1	0.72874175
61	RPS6KA5	0.71278029
62	BCKDK	0.70898457
63	FGFR2	0.69227338
64	PLK2	0.68166199
65	SGK223	0.65860114
66	SGK494	0.65860114
67	IRAK1	0.65708116
68	MUSK	0.62490760
69	OBSCN	0.62035471
70	CDK3	0.61624951
71	MAP3K2	0.56579860
72	PRKCQ	0.55798505
73	CAMK4	0.53447385
74	CSNK1G1	0.49897490
75	CAMK2A	0.46465785
76	PRKG1	0.46095840
77	CSNK1G3	0.45564162
78	ITK	0.44527778
79	GRK7	0.44300813
80	CAMK1G	0.43860262
81	PRKACA	0.43551724
82	CAMKK1	0.42511265
83	BLK	0.41805352
84	TEC	0.41689390
85	CDC7	0.40951399
86	MAP2K7	0.39897274
87	DYRK1A	0.39805369
88	PRKACB	0.37291679
89	CSNK1A1	0.36792045
90	TAF1	0.36080358
91	SYK	0.35679855
92	TYRO3	0.35011777
93	PLK1	0.33888396
94	STK38L	0.33657548
95	TRIM28	0.31947587
96	STK11	0.31366281
97	CSNK1E	0.30010612
98	ADRBK1	0.29486108
99	TTK	0.29282691
100	AKT3	0.28322337

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.55076358
2	Ribosome_Homo sapiens_hsa03010	4.47468830
3	Parkinsons disease_Homo sapiens_hsa05012	4.04206300
4	Nicotine addiction_Homo sapiens_hsa05033	2.77749688
5	Alzheimers disease_Homo sapiens_hsa05010	2.74225904
6	Huntingtons disease_Homo sapiens_hsa05016	2.67571421
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.67194697
8	Protein export_Homo sapiens_hsa03060	2.59280190
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.20355189
10	Proteasome_Homo sapiens_hsa03050	2.12461941
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.11996670
12	Phototransduction_Homo sapiens_hsa04744	2.06274038
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04017590
14	RNA polymerase_Homo sapiens_hsa03020	2.03378579
15	Cocaine addiction_Homo sapiens_hsa05030	1.98111394
16	Amphetamine addiction_Homo sapiens_hsa05031	1.96308909
17	Butanoate metabolism_Homo sapiens_hsa00650	1.84153435
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73118655
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.56038132
20	Taste transduction_Homo sapiens_hsa04742	1.54241154
21	Circadian entrainment_Homo sapiens_hsa04713	1.42694288
22	Morphine addiction_Homo sapiens_hsa05032	1.40823628
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.40200021
24	GABAergic synapse_Homo sapiens_hsa04727	1.37972290
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36171291
26	Olfactory transduction_Homo sapiens_hsa04740	1.34144175
27	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.33198723
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.31958491
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25271669
30	Homologous recombination_Homo sapiens_hsa03440	1.22528332
31	RNA degradation_Homo sapiens_hsa03018	1.20960223
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12481007
33	Serotonergic synapse_Homo sapiens_hsa04726	1.06143616
34	Basal transcription factors_Homo sapiens_hsa03022	1.05290094
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.05012570
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.03005688
37	Mismatch repair_Homo sapiens_hsa03430	0.99543905
38	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93160823
39	Caffeine metabolism_Homo sapiens_hsa00232	0.91079936
40	Spliceosome_Homo sapiens_hsa03040	0.88732193
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.87274641
42	Dopaminergic synapse_Homo sapiens_hsa04728	0.85839257
43	RNA transport_Homo sapiens_hsa03013	0.83800484
44	Purine metabolism_Homo sapiens_hsa00230	0.83406338
45	Oocyte meiosis_Homo sapiens_hsa04114	0.82750803
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.82219161
47	Long-term potentiation_Homo sapiens_hsa04720	0.82218565
48	Insulin secretion_Homo sapiens_hsa04911	0.81026137
49	Renin secretion_Homo sapiens_hsa04924	0.79082417
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75536393
51	Wnt signaling pathway_Homo sapiens_hsa04310	0.75164438
52	Melanogenesis_Homo sapiens_hsa04916	0.74211425
53	Cholinergic synapse_Homo sapiens_hsa04725	0.71317120
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71022631
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70477465
56	Alcoholism_Homo sapiens_hsa05034	0.67611411
57	Axon guidance_Homo sapiens_hsa04360	0.65694104
58	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64203246
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64016674
60	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.61899160
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.61456382
62	cAMP signaling pathway_Homo sapiens_hsa04024	0.61345296
63	Hippo signaling pathway_Homo sapiens_hsa04390	0.59076917
64	Gap junction_Homo sapiens_hsa04540	0.59075399
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58842833
66	Salivary secretion_Homo sapiens_hsa04970	0.57126914
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.56028679
68	Folate biosynthesis_Homo sapiens_hsa00790	0.55506942
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.53590352
70	Retinol metabolism_Homo sapiens_hsa00830	0.51843730
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51689686
72	Histidine metabolism_Homo sapiens_hsa00340	0.50875228
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50607014
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.49965034
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49763808
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48013594
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.45706413
78	Metabolic pathways_Homo sapiens_hsa01100	0.45511637
79	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44175635
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41854986
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41283375
82	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.39877168
83	Long-term depression_Homo sapiens_hsa04730	0.37843405
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.36742951
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35527768
86	Propanoate metabolism_Homo sapiens_hsa00640	0.34445960
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34163239
88	Circadian rhythm_Homo sapiens_hsa04710	0.33787558
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32253327
90	Regulation of autophagy_Homo sapiens_hsa04140	0.29523870
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29156853
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.29107943
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.28825122
94	Gastric acid secretion_Homo sapiens_hsa04971	0.28298469
95	Peroxisome_Homo sapiens_hsa04146	0.27916996
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27669562
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27230921
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.26726075
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.26304038
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.25246708

TLK2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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