TLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.63300681
2response to pheromone (GO:0019236)5.97370575
3chondrocyte proliferation (GO:0035988)5.71278714
4sequestering of extracellular ligand from receptor (GO:0035581)5.43304455
5midgut development (GO:0007494)5.19367611
6polyketide metabolic process (GO:0030638)5.00946670
7doxorubicin metabolic process (GO:0044598)5.00946670
8daunorubicin metabolic process (GO:0044597)5.00946670
9homocysteine metabolic process (GO:0050667)4.71691526
10peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.62244507
11cAMP catabolic process (GO:0006198)4.60092932
12extracellular negative regulation of signal transduction (GO:1900116)4.51852031
13extracellular regulation of signal transduction (GO:1900115)4.51852031
14regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.15309129
15negative regulation of hormone biosynthetic process (GO:0032353)4.06997278
16cyclic nucleotide catabolic process (GO:0009214)3.97004970
17wound healing, spreading of epidermal cells (GO:0035313)3.93828613
18negative regulation of complement activation (GO:0045916)3.92396751
19positive regulation of vascular permeability (GO:0043117)3.89278485
20collagen fibril organization (GO:0030199)3.82881211
21cGMP-mediated signaling (GO:0019934)3.80134901
22mesenchymal-epithelial cell signaling (GO:0060638)3.78381749
23positive regulation of odontogenesis (GO:0042482)3.76769820
24hepatocyte differentiation (GO:0070365)3.74240034
25negative regulation of hormone metabolic process (GO:0032351)3.74217324
26negative regulation of vascular permeability (GO:0043116)3.66167470
27regulation of steroid hormone biosynthetic process (GO:0090030)3.61504317
28citrulline biosynthetic process (GO:0019240)3.61036841
29desmosome organization (GO:0002934)3.58879201
30regulation of cell communication by electrical coupling (GO:0010649)3.55887821
31pericardium development (GO:0060039)3.54412033
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.51160846
33positive regulation of p38MAPK cascade (GO:1900745)3.49828100
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.48655628
35axon extension involved in axon guidance (GO:0048846)3.48655628
36bone trabecula formation (GO:0060346)3.48047514
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.43673608
38iron ion import (GO:0097286)3.43124948
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.41838791
40nuclear pore complex assembly (GO:0051292)3.41468003
41positive regulation of osteoblast proliferation (GO:0033690)3.37537258
42negative regulation of protein activation cascade (GO:2000258)3.35721816
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33478060
44ganglion development (GO:0061548)3.32858416
45negative regulation of stem cell proliferation (GO:2000647)3.30494118
46urea cycle (GO:0000050)3.30228380
47regulation of centriole replication (GO:0046599)3.30013487
48cellular response to epinephrine stimulus (GO:0071872)3.29119321
49cell-substrate junction assembly (GO:0007044)3.28879337
50pathway-restricted SMAD protein phosphorylation (GO:0060389)3.28847167
51negative regulation of fatty acid transport (GO:2000192)3.27489087
52atrioventricular valve morphogenesis (GO:0003181)3.22116101
53negative regulation of keratinocyte proliferation (GO:0010839)3.20456923
54wound healing, spreading of cells (GO:0044319)3.17366399
55regulation of vascular permeability (GO:0043114)3.13758462
56notochord development (GO:0030903)3.12411251
57regulation of glucocorticoid metabolic process (GO:0031943)3.12055726
58facial nerve structural organization (GO:0021612)3.08556133
59negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.99237022
60mesenchymal cell differentiation involved in renal system development (GO:2001012)2.99230730
61mesenchymal cell differentiation involved in kidney development (GO:0072161)2.99230730
62nuclear pore organization (GO:0006999)2.98828171
63cAMP-mediated signaling (GO:0019933)2.96738199
64positive regulation of cartilage development (GO:0061036)2.94667612
65G-protein coupled receptor internalization (GO:0002031)2.94604359
66urea metabolic process (GO:0019627)2.93666038
67cAMP metabolic process (GO:0046058)2.93444386
68regulation of relaxation of muscle (GO:1901077)2.92357179
69regulation of cardiac muscle cell contraction (GO:0086004)2.91413210
70metanephric mesenchyme development (GO:0072075)2.90751892
71positive regulation of fibroblast migration (GO:0010763)2.90506760
72polarized epithelial cell differentiation (GO:0030859)2.90373493
73aminoglycoside antibiotic metabolic process (GO:0030647)2.88938775
74prenylation (GO:0097354)2.86462896
75protein prenylation (GO:0018342)2.86462896
76artery development (GO:0060840)2.86314628
77endodermal cell differentiation (GO:0035987)2.85908403
78negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.84966259
79regulation of p38MAPK cascade (GO:1900744)2.84566031
80regulation of non-canonical Wnt signaling pathway (GO:2000050)2.84545372
81positive regulation of cellular amide metabolic process (GO:0034250)2.84190466
82response to epinephrine (GO:0071871)2.83950041
83drinking behavior (GO:0042756)2.82511747
84cell adhesion mediated by integrin (GO:0033627)2.80854072
85neuron remodeling (GO:0016322)2.79851899
86citrulline metabolic process (GO:0000052)2.78988160
87detection of molecule of bacterial origin (GO:0032490)2.78698471
88inner ear receptor stereocilium organization (GO:0060122)2.76311586
89renal filtration (GO:0097205)2.72850461
90regulation of establishment or maintenance of cell polarity (GO:0032878)2.70420668
91pore complex assembly (GO:0046931)2.69949031
92morphogenesis of an epithelial sheet (GO:0002011)2.69635648
93cellular response to vitamin D (GO:0071305)2.69101214
94cerebral cortex radially oriented cell migration (GO:0021799)2.68229642
95endothelium development (GO:0003158)2.67598922
96cranial nerve structural organization (GO:0021604)2.67316228
97omega-hydroxylase P450 pathway (GO:0097267)2.67293099
98regulation of mononuclear cell migration (GO:0071675)2.66837168
99negative chemotaxis (GO:0050919)2.66190520
100insulin-like growth factor receptor signaling pathway (GO:0048009)2.64962317
101cartilage morphogenesis (GO:0060536)2.64673877
102substrate-dependent cell migration (GO:0006929)2.64285240
103endothelial cell morphogenesis (GO:0001886)2.64094347
104dorsal/ventral axis specification (GO:0009950)2.61568679
105energy homeostasis (GO:0097009)2.61404103
106branching involved in salivary gland morphogenesis (GO:0060445)2.60399160
107regulation of interleukin-8 secretion (GO:2000482)2.60265164
108cardiac epithelial to mesenchymal transition (GO:0060317)2.60159107
109response to growth hormone (GO:0060416)2.59707962
110regulation of keratinocyte proliferation (GO:0010837)2.59629729
111sprouting angiogenesis (GO:0002040)2.58247733
112smooth muscle tissue development (GO:0048745)2.58126639
113negative regulation of gluconeogenesis (GO:0045721)2.58093360
114kidney mesenchyme development (GO:0072074)2.57672163
115glomerular visceral epithelial cell development (GO:0072015)2.57473859
116bone remodeling (GO:0046849)2.56624747
117chondrocyte development (GO:0002063)2.56112893
118negative regulation of cardiac muscle tissue development (GO:0055026)2.55064493
119negative regulation of axon guidance (GO:1902668)2.54602953
120lateral ventricle development (GO:0021670)2.53962904
121positive regulation of heat generation (GO:0031652)2.53922008
122glutamate secretion (GO:0014047)2.53748551
123establishment of apical/basal cell polarity (GO:0035089)2.53607673
124glomerular filtration (GO:0003094)2.52445940
125serotonin receptor signaling pathway (GO:0007210)2.52231443
126negative regulation of embryonic development (GO:0045992)2.52173366
127auditory receptor cell stereocilium organization (GO:0060088)2.51331697
128response to dexamethasone (GO:0071548)2.50954992
129negative regulation of humoral immune response (GO:0002921)2.50915081
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.50534879
131craniofacial suture morphogenesis (GO:0097094)2.50014751
132negative regulation of leukocyte chemotaxis (GO:0002689)2.48868616
133replicative senescence (GO:0090399)2.48751908
134lipid translocation (GO:0034204)2.48705112
135phospholipid translocation (GO:0045332)2.48705112
136phagocytosis, engulfment (GO:0006911)2.48183910
137embryonic forelimb morphogenesis (GO:0035115)2.47651540
138behavioral response to pain (GO:0048266)2.47200738
139negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.46808145
140protein kinase C signaling (GO:0070528)2.46451932
141cell surface receptor signaling pathway involved in heart development (GO:0061311)2.46351699
142gamma-aminobutyric acid transport (GO:0015812)2.46236311
143retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43881850
144Rap protein signal transduction (GO:0032486)2.43743906
145genitalia morphogenesis (GO:0035112)2.42545054
146positive regulation of monocyte chemotaxis (GO:0090026)2.42367204
147negative regulation of chondrocyte differentiation (GO:0032331)2.42038251
148positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.41829765
149protein localization to cell surface (GO:0034394)2.41788693
150cranial nerve morphogenesis (GO:0021602)2.41177798
151neural crest cell development (GO:0014032)2.40847261
152negative regulation of axon extension involved in axon guidance (GO:0048843)2.40361745
153cyclic nucleotide metabolic process (GO:0009187)2.39616105
154cellular potassium ion homeostasis (GO:0030007)2.39166896
155nitrogen cycle metabolic process (GO:0071941)2.38628928
156positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38045548
157regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.36827264
158dermatan sulfate metabolic process (GO:0030205)2.36261568
159import into cell (GO:0098657)2.36003557
160regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.34549055
161regulation of monocyte chemotaxis (GO:0090025)2.34546510
162regulation of hormone biosynthetic process (GO:0046885)2.33801571
163activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.33455481
164dermatan sulfate biosynthetic process (GO:0030208)2.32816779
165peptide cross-linking (GO:0018149)2.31503182
166mesenchymal cell differentiation (GO:0048762)2.30279297
167chemical homeostasis within a tissue (GO:0048875)2.30041509
168cyclic-nucleotide-mediated signaling (GO:0019935)2.29247788
169tyrosine phosphorylation of STAT protein (GO:0007260)2.29099367
170regulation of phospholipid biosynthetic process (GO:0071071)2.29017366
171layer formation in cerebral cortex (GO:0021819)2.28784654
172endocrine hormone secretion (GO:0060986)2.28631412
173female gonad development (GO:0008585)2.27048495
174regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26828339
175regulation of fever generation (GO:0031620)2.26401755
176cell proliferation in forebrain (GO:0021846)2.25338545
177negative regulation of osteoblast proliferation (GO:0033689)2.24605838
178negative regulation of mast cell activation (GO:0033004)2.22107002
179positive regulation of cardiac muscle cell differentiation (GO:2000727)2.21255786
180lymphangiogenesis (GO:0001946)2.20330829
181positive regulation of CREB transcription factor activity (GO:0032793)2.19741041
182extracellular matrix assembly (GO:0085029)2.19098868
183positive regulation of interleukin-1 beta secretion (GO:0050718)2.18157584
184startle response (GO:0001964)2.17006571
185olfactory bulb development (GO:0021772)2.16785316
186positive regulation of macrophage activation (GO:0043032)2.13859469
187embryonic cranial skeleton morphogenesis (GO:0048701)2.13304284
188presynaptic membrane assembly (GO:0097105)2.13231164
189regulation of G0 to G1 transition (GO:0070316)2.13214807
190negative regulation of homotypic cell-cell adhesion (GO:0034111)2.12801486
191forelimb morphogenesis (GO:0035136)2.12320501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.61342330
2GBX2_23144817_ChIP-Seq_PC3_Human3.82617178
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.81680787
4EZH2_22144423_ChIP-Seq_EOC_Human3.38113427
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27498963
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.81410850
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.49683254
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48194677
9ZNF263_19887448_ChIP-Seq_K562_Human2.36997701
10* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33027710
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32680228
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29426260
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26442580
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26151711
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.21861101
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15415391
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.12203297
18* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11846939
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11628267
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10687015
21* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10016470
22* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10016470
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.08612263
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.03906256
25* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01442248
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.97816255
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.95157081
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95124362
29AHR_22903824_ChIP-Seq_MCF-7_Human1.92871161
30* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91327483
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90779305
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89566760
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88769234
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.87042863
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85545131
36* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84207470
37* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83660162
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80377654
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78349425
40* P300_19829295_ChIP-Seq_ESCs_Human1.76312714
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.76274601
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.74809458
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69837326
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67534397
45* TP53_18474530_ChIP-ChIP_U2OS_Human1.66903597
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66351245
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.65798235
48AR_21909140_ChIP-Seq_LNCAP_Human1.64417195
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64366981
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.62832985
51TP53_16413492_ChIP-PET_HCT116_Human1.60317262
52SMAD4_21799915_ChIP-Seq_A2780_Human1.57842341
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57520308
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.55637421
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55521643
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55521643
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.55403180
58RNF2_27304074_Chip-Seq_NSC_Mouse1.54086222
59IGF1R_20145208_ChIP-Seq_DFB_Human1.53911456
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53016942
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51414337
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51252575
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.48621789
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.47618562
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47537623
66TAF15_26573619_Chip-Seq_HEK293_Human1.47409235
67CJUN_26792858_Chip-Seq_BT549_Human1.46942973
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46324069
69* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46305506
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.45454893
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45169469
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43237754
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41338646
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38990479
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.38542966
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38202514
77EWS_26573619_Chip-Seq_HEK293_Human1.37416348
78* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.37014896
79P53_22387025_ChIP-Seq_ESCs_Mouse1.36742038
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36511278
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34161120
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33383596
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.31746139
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.31686688
85* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31323513
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31223297
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.30582207
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30339298
89ER_23166858_ChIP-Seq_MCF-7_Human1.30076836
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29358459
91FUS_26573619_Chip-Seq_HEK293_Human1.28929398
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.28674366
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.27931879
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.27614840
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27221335
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25735570
97AR_21572438_ChIP-Seq_LNCaP_Human1.25112760
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24768267
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23905789
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23488364
101NMYC_18555785_Chip-Seq_ESCs_Mouse1.21784386
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21230545
103* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21186806
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21045792
105AR_25329375_ChIP-Seq_VCAP_Human1.20758222
106* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20615907
107DROSHA_22980978_ChIP-Seq_HELA_Human1.20574769
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.19422779
109* JUN_21703547_ChIP-Seq_K562_Human1.18807267
110BRD4_25478319_ChIP-Seq_HGPS_Human1.18779422
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18763143
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18628877
113CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17824835
114* STAT3_23295773_ChIP-Seq_U87_Human1.17592560
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17314244
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17109628
117SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16709006
118* TP63_23658742_ChIP-Seq_EP156T_Human1.16561218
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.15952095
120* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15685601
121* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15028182
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13257035
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13257035
124CLOCK_20551151_ChIP-Seq_293T_Human1.13035790
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.12725399
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11786709
127* RUNX2_22187159_ChIP-Seq_PCA_Human1.11249867
128P300_18555785_Chip-Seq_ESCs_Mouse1.10110634
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.09872311
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08576162
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07167954
132TBL1_22424771_ChIP-Seq_293T_Human1.07011233
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05861266
134* TCF4_23295773_ChIP-Seq_U87_Human1.05694426
135RXR_22108803_ChIP-Seq_LS180_Human1.05574111
136CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05519670
137SOX2_21211035_ChIP-Seq_LN229_Gbm1.04885138
138* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04393688
139* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03473903
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03290035
141SMAD3_21741376_ChIP-Seq_HESCs_Human1.00647806
142SOX9_26525672_Chip-Seq_HEART_Mouse0.98527677
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93878828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.87770671
2MP0000579_abnormal_nail_morphology3.82568288
3MP0005503_abnormal_tendon_morphology3.77417081
4MP0005083_abnormal_biliary_tract3.38484647
5MP0000566_synostosis3.27231573
6MP0005275_abnormal_skin_tensile3.08389893
7MP0002102_abnormal_ear_morphology2.83926753
8MP0005257_abnormal_intraocular_pressure2.80300014
9MP0010234_abnormal_vibrissa_follicle2.76550749
10MP0003279_aneurysm2.63159790
11MP0003941_abnormal_skin_development2.48660650
12MP0009250_abnormal_appendicular_skeleto2.37939469
13MP0001188_hyperpigmentation2.36437858
14MP0005171_absent_coat_pigmentation2.23020526
15MP0008004_abnormal_stomach_pH2.18453110
16MP0006292_abnormal_olfactory_placode2.12295580
17MP0003385_abnormal_body_wall2.02841982
18MP0010030_abnormal_orbit_morphology1.99210419
19MP0005508_abnormal_skeleton_morphology1.95716708
20MP0000049_abnormal_middle_ear1.91954555
21MP0005645_abnormal_hypothalamus_physiol1.84118365
22MP0005623_abnormal_meninges_morphology1.80413429
23MP0002234_abnormal_pharynx_morphology1.78783970
24MP0000013_abnormal_adipose_tissue1.78151600
25MP0005085_abnormal_gallbladder_physiolo1.75781053
26MP0003755_abnormal_palate_morphology1.74611457
27MP0009384_cardiac_valve_regurgitation1.73886826
28MP0001958_emphysema1.72835943
29MP0002009_preneoplasia1.68055918
30* MP0006138_congestive_heart_failure1.67263507
31MP0004233_abnormal_muscle_weight1.62264908
32MP0001299_abnormal_eye_distance/1.61766125
33MP0005646_abnormal_pituitary_gland1.60281833
34MP0002233_abnormal_nose_morphology1.58893771
35MP0003705_abnormal_hypodermis_morpholog1.58580104
36MP0002177_abnormal_outer_ear1.57201546
37MP0002249_abnormal_larynx_morphology1.54595260
38MP0003937_abnormal_limbs/digits/tail_de1.53894378
39MP0001346_abnormal_lacrimal_gland1.52987130
40MP0008057_abnormal_DNA_replication1.52375842
41MP0001348_abnormal_lacrimal_gland1.49434305
42MP0010678_abnormal_skin_adnexa1.47843896
43MP0004782_abnormal_surfactant_physiolog1.47179135
44MP0003718_maternal_effect1.47083303
45MP0005167_abnormal_blood-brain_barrier1.46703176
46MP0002277_abnormal_respiratory_mucosa1.45908631
47MP0000569_abnormal_digit_pigmentation1.44230897
48MP0010386_abnormal_urinary_bladder1.36621399
49MP0004134_abnormal_chest_morphology1.34914011
50MP0004742_abnormal_vestibular_system1.34779682
51MP0003122_maternal_imprinting1.32909296
52MP0003566_abnormal_cell_adhesion1.31287038
53MP0002938_white_spotting1.30558892
54MP0003045_fibrosis1.28305467
55MP0001542_abnormal_bone_strength1.27210591
56MP0000163_abnormal_cartilage_morphology1.26716044
57MP0002116_abnormal_craniofacial_bone1.26000691
58MP0002113_abnormal_skeleton_development1.25387289
59MP0004272_abnormal_basement_membrane1.24891657
60MP0002295_abnormal_pulmonary_circulatio1.24532354
61MP0000003_abnormal_adipose_tissue1.23609603
62MP0002736_abnormal_nociception_after1.23345356
63MP0006276_abnormal_autonomic_nervous1.22971642
64MP0005390_skeleton_phenotype1.22513840
65MP0009697_abnormal_copulation1.21761030
66MP0002109_abnormal_limb_morphology1.21415862
67MP0003868_abnormal_feces_composition1.18863042
68MP0000432_abnormal_head_morphology1.18745342
69MP0002115_abnormal_skeleton_extremities1.18511069
70MP0000537_abnormal_urethra_morphology1.17503019
71MP0000383_abnormal_hair_follicle1.16373394
72MP0002998_abnormal_bone_remodeling1.15461686
73MP0003935_abnormal_craniofacial_develop1.13578350
74MP0000678_abnormal_parathyroid_gland1.13567774
75MP0002060_abnormal_skin_morphology1.13004398
76MP0004859_abnormal_synaptic_plasticity1.12618910
77MP0003091_abnormal_cell_migration1.10837523
78MP0000762_abnormal_tongue_morphology1.10299320
79MP0002932_abnormal_joint_morphology1.07865310
80MP0001486_abnormal_startle_reflex1.07755571
81MP0003942_abnormal_urinary_system1.07687293
82MP0002896_abnormal_bone_mineralization1.06927001
83MP0000767_abnormal_smooth_muscle1.06408904
84MP0004215_abnormal_myocardial_fiber1.06311466
85MP0002697_abnormal_eye_size1.06101124
86MP0003828_pulmonary_edema1.05266164
87MP0005187_abnormal_penis_morphology1.02386141
88MP0002877_abnormal_melanocyte_morpholog1.02279780
89MP0001986_abnormal_taste_sensitivity1.02019467
90MP0002796_impaired_skin_barrier1.01889294
91MP0005670_abnormal_white_adipose1.01833729
92MP0000681_abnormal_thyroid_gland1.00657136
93MP0006072_abnormal_retinal_apoptosis1.00252551
94MP0008775_abnormal_heart_ventricle0.98958387
95MP0003787_abnormal_imprinting0.97603389
96MP0004084_abnormal_cardiac_muscle0.96053151
97MP0000026_abnormal_inner_ear0.94671374
98MP0005360_urolithiasis0.92786617
99MP0010771_integument_phenotype0.91996517
100MP0005423_abnormal_somatic_nervous0.91982892
101MP0005501_abnormal_skin_physiology0.91744131
102MP0005409_darkened_coat_color0.88495644
103MP0000467_abnormal_esophagus_morphology0.88392241
104MP0001177_atelectasis0.88074627
105MP0005395_other_phenotype0.88006230
106MP0002282_abnormal_trachea_morphology0.87761576
107MP0002108_abnormal_muscle_morphology0.87048141
108MP0002111_abnormal_tail_morphology0.86519863
109MP0004085_abnormal_heartbeat0.85852689
110MP0002735_abnormal_chemical_nociception0.85623265
111MP0002184_abnormal_innervation0.85080427
112MP0003121_genomic_imprinting0.84604950
113MP0005248_abnormal_Harderian_gland0.83968341
114MP0001502_abnormal_circadian_rhythm0.83751880
115MP0002163_abnormal_gland_morphology0.83450289
116MP0005367_renal/urinary_system_phenotyp0.82992317
117MP0000516_abnormal_urinary_system0.82992317
118MP0002114_abnormal_axial_skeleton0.82387066
119MP0003984_embryonic_growth_retardation0.81014075
120MP0002088_abnormal_embryonic_growth/wei0.80622789
121MP0001968_abnormal_touch/_nociception0.80564684
122MP0000778_abnormal_nervous_system0.79754638
123MP0000751_myopathy0.79069763
124MP0009780_abnormal_chondrocyte_physiolo0.78372007
125MP0010368_abnormal_lymphatic_system0.78343432
126MP0003890_abnormal_embryonic-extraembry0.77774975
127MP0003453_abnormal_keratinocyte_physiol0.77577508
128MP0005595_abnormal_vascular_smooth0.77472929
129MP0000428_abnormal_craniofacial_morphol0.77271759
130MP0004484_altered_response_of0.76171769
131MP0009046_muscle_twitch0.76001431
132MP0001879_abnormal_lymphatic_vessel0.75940600
133MP0006054_spinal_hemorrhage0.75895228
134MP0002160_abnormal_reproductive_system0.75581350
135MP0002089_abnormal_postnatal_growth/wei0.75065891
136MP0003959_abnormal_lean_body0.74390335
137MP0005084_abnormal_gallbladder_morpholo0.74217070
138MP0000631_abnormal_neuroendocrine_gland0.73260222
139MP0002557_abnormal_social/conspecific_i0.71870711
140MP0000733_abnormal_muscle_development0.71606798
141MP0005380_embryogenesis_phenotype0.70328044
142MP0001672_abnormal_embryogenesis/_devel0.70328044
143MP0003938_abnormal_ear_development0.69998450
144MP0008260_abnormal_autophagy0.69892096
145MP0005197_abnormal_uvea_morphology0.69425274
146MP0003950_abnormal_plasma_membrane0.68306608
147MP0002168_other_aberrant_phenotype0.67900634
148MP0003795_abnormal_bone_structure0.67656542
149MP0005647_abnormal_sex_gland0.66773357
150MP0001849_ear_inflammation0.65043350
151* MP0002925_abnormal_cardiovascular_devel0.65042408
152MP0002086_abnormal_extraembryonic_tissu0.64795991
153MP0001216_abnormal_epidermal_layer0.64317835
154MP0002084_abnormal_developmental_patter0.64249370
155MP0003567_abnormal_fetal_cardiomyocyte0.64116797
156MP0001340_abnormal_eyelid_morphology0.60509023

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.90124504
2Milia (HP:0001056)4.24349166
3Protrusio acetabuli (HP:0003179)4.15590165
4Onycholysis (HP:0001806)4.07870598
5Aortic dissection (HP:0002647)3.86082969
6Atrophic scars (HP:0001075)3.64014616
7Fair hair (HP:0002286)3.62968724
8Fragile nails (HP:0001808)3.50097047
9Right ventricular cardiomyopathy (HP:0011663)3.47499208
10Atonic seizures (HP:0010819)3.33612027
11Soft skin (HP:0000977)3.19438036
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.18775075
13Mesomelia (HP:0003027)3.11870976
14Follicular hyperkeratosis (HP:0007502)3.10246569
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10100619
16Fragile skin (HP:0001030)3.06937210
17Peritonitis (HP:0002586)2.99729304
18Plantar hyperkeratosis (HP:0007556)2.98660553
19Abnormality of dentin (HP:0010299)2.95448571
20Cerebellar dysplasia (HP:0007033)2.90243777
21Neonatal short-limb short stature (HP:0008921)2.89960453
22Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.83123016
23Thick nail (HP:0001805)2.82381246
24Shallow orbits (HP:0000586)2.77011322
25Abnormality of the nasal septum (HP:0000419)2.73760000
26Knee flexion contracture (HP:0006380)2.71094365
27Syringomyelia (HP:0003396)2.70211030
28Spinal cord lesions (HP:0100561)2.70211030
29Lip pit (HP:0100267)2.68265677
30Prostate neoplasm (HP:0100787)2.67912826
31Morphological abnormality of the middle ear (HP:0008609)2.67194202
32Chromsome breakage (HP:0040012)2.62932382
33Blue irides (HP:0000635)2.59023730
34Abnormality of incisor morphology (HP:0011063)2.55044805
35Unilateral renal agenesis (HP:0000122)2.52035805
36Septo-optic dysplasia (HP:0100842)2.50599690
37Short nail (HP:0001799)2.47977096
38Osteolytic defects of the hand bones (HP:0009699)2.47696786
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.47696786
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.47028283
41Generalized hypopigmentation of hair (HP:0011358)2.46867675
42Genu recurvatum (HP:0002816)2.46353050
43Fibular aplasia (HP:0002990)2.46120682
44Febrile seizures (HP:0002373)2.44907775
45Abnormality of the ischium (HP:0003174)2.44249769
46Bladder diverticulum (HP:0000015)2.40175145
47Dilatation of the ascending aorta (HP:0005111)2.38198474
48Vascular tortuosity (HP:0004948)2.34377454
49Abnormality of nail color (HP:0100643)2.33350753
50Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.33088877
51Asymmetry of the thorax (HP:0001555)2.28348109
52Mild short stature (HP:0003502)2.27373117
53Sparse lateral eyebrow (HP:0005338)2.26070791
54Abnormal auditory evoked potentials (HP:0006958)2.25191895
55Increased circulating renin level (HP:0000848)2.24629950
56Abnormality of the right ventricle (HP:0001707)2.24128563
57Xerostomia (HP:0000217)2.20275955
58Abnormality of the parietal bone (HP:0002696)2.19871395
59Aortic aneurysm (HP:0004942)2.19630359
60Pterygium (HP:0001059)2.17411774
61Short middle phalanx of the 5th finger (HP:0004220)2.16253911
62Cardiovascular calcification (HP:0011915)2.15830005
63Short chin (HP:0000331)2.14640282
64Dysmetric saccades (HP:0000641)2.13144962
65Tibial bowing (HP:0002982)2.12924659
66Congenital sensorineural hearing impairment (HP:0008527)2.09805396
67Absent frontal sinuses (HP:0002688)2.07982948
68Infantile muscular hypotonia (HP:0008947)2.07223161
69Myotonia (HP:0002486)2.06903105
70Wormian bones (HP:0002645)2.06693908
71Nail dystrophy (HP:0008404)2.04480803
72Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.03904169
73Alopecia of scalp (HP:0002293)2.02885396
74Increased number of teeth (HP:0011069)2.01420403
75Ankyloglossia (HP:0010296)2.01304885
76Aplasia cutis congenita (HP:0001057)1.99550929
77Aplasia of the phalanges of the hand (HP:0009802)1.99525545
78Aplasia involving bones of the extremities (HP:0009825)1.99525545
79Aplasia involving bones of the upper limbs (HP:0009823)1.99525545
80Aortic regurgitation (HP:0001659)1.99435336
81Hypotrichosis (HP:0001006)1.98925523
82Alkalosis (HP:0001948)1.97659837
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.97225929
84Duplicated collecting system (HP:0000081)1.96842282
85Wrist flexion contracture (HP:0001239)1.96330926
86Absence seizures (HP:0002121)1.94971315
87Bifid uvula (HP:0000193)1.93549781
88Broad nasal tip (HP:0000455)1.93384433
89Bell-shaped thorax (HP:0001591)1.92904723
90Blue sclerae (HP:0000592)1.92621028
91Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.92607234
92Craniofacial hyperostosis (HP:0004493)1.92585741
93Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.91295494
94Aplasia of the musculature (HP:0100854)1.91020998
95Abnormality of the 2nd finger (HP:0004100)1.90492763
96Abnormality of the renal collecting system (HP:0004742)1.90462279
97Broad face (HP:0000283)1.89829649
98Submucous cleft hard palate (HP:0000176)1.88896617
99Biconcave vertebral bodies (HP:0004586)1.88248248
100Coronal craniosynostosis (HP:0004440)1.88130397
101Cervical subluxation (HP:0003308)1.87769163
102Vascular calcification (HP:0004934)1.87562765
103Arterial tortuosity (HP:0005116)1.87333410
104Hypoplastic labia majora (HP:0000059)1.86970246
105Corneal dystrophy (HP:0001131)1.85790900
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85573065
107Hypoplasia of dental enamel (HP:0006297)1.83643235
108Abnormality of the labia majora (HP:0012881)1.83637896
109Cerebral aneurysm (HP:0004944)1.82982236
110Patchy hypopigmentation of hair (HP:0011365)1.81839662
111Distal lower limb amyotrophy (HP:0008944)1.80564421
112White forelock (HP:0002211)1.80370267
113Ridged nail (HP:0001807)1.80152995
114Ectopic kidney (HP:0000086)1.80050615
115Cranial hyperostosis (HP:0004437)1.79627773
116Cubitus valgus (HP:0002967)1.79616075
117Spondylolisthesis (HP:0003302)1.77765064
118Woolly hair (HP:0002224)1.77427628
119Spinal cord compression (HP:0002176)1.77318631
120Limited hip movement (HP:0008800)1.76942289
121Palmoplantar hyperkeratosis (HP:0000972)1.76313367
122Keratoconus (HP:0000563)1.76295917
123Increased corneal curvature (HP:0100692)1.76295917
124Vertebral compression fractures (HP:0002953)1.75407296
125Aplasia/Hypoplasia of the lens (HP:0008063)1.74271186
126Cheilitis (HP:0100825)1.74152348
127Cutaneous finger syndactyly (HP:0010554)1.72943439
128Thickened helices (HP:0000391)1.72397696
129Depressed nasal tip (HP:0000437)1.70943072
130Short hallux (HP:0010109)1.70693925
131Hypoplasia of the iris (HP:0007676)1.70126801
132Mitral valve prolapse (HP:0001634)1.70125525
133Bowel diverticulosis (HP:0005222)1.69635251
134Osteomalacia (HP:0002749)1.69062776
135Natal tooth (HP:0000695)1.68508564
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68477817
137Abnormality of the frontal sinuses (HP:0002687)1.68463689
138Bilateral sensorineural hearing impairment (HP:0008619)1.68079704
139Flexion contracture of toe (HP:0005830)1.67807771
140Joint contractures involving the joints of the feet (HP:0100492)1.67807771
141Renal dysplasia (HP:0000110)1.67676926
142Abnormal delivery (HP:0001787)1.67466491
143Synostosis of carpal bones (HP:0005048)1.66044542
144Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.65868662
145Sensory axonal neuropathy (HP:0003390)1.64704887
146Broad ribs (HP:0000885)1.64544334
147Tracheomalacia (HP:0002779)1.63575852
148Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.62988772
149Preaxial foot polydactyly (HP:0001841)1.62798850
150Abnormality of pain sensation (HP:0010832)1.62400671
151Impaired pain sensation (HP:0007328)1.62400671
152Palmar hyperkeratosis (HP:0010765)1.61963903
153Subacute progressive viral hepatitis (HP:0006572)1.61938170
154Upper limb muscle weakness (HP:0003484)1.61754527
155Aplasia/Hypoplasia of the fibula (HP:0006492)1.61567565
156Overgrowth (HP:0001548)1.60897949
157Ectopia lentis (HP:0001083)1.60782491
158Breech presentation (HP:0001623)1.60459130
159Mixed hearing impairment (HP:0000410)1.59930251
160Recurrent corneal erosions (HP:0000495)1.59905151
161True hermaphroditism (HP:0010459)1.59610167
162Calcaneovalgus deformity (HP:0001848)1.59357046
163Abnormality of the middle phalanges of the toes (HP:0010183)1.58916371
164Parakeratosis (HP:0001036)1.58882761
165Humeroradial synostosis (HP:0003041)1.58656952
166Synostosis involving the elbow (HP:0003938)1.58656952
167Elbow flexion contracture (HP:0002987)1.58028269
168Symphalangism affecting the phalanges of the hand (HP:0009773)1.57816378
169Mitral stenosis (HP:0001718)1.57703171
170Deformed tarsal bones (HP:0008119)1.57357174
171Camptodactyly of toe (HP:0001836)1.57302918
172Aortic valve stenosis (HP:0001650)1.56110195
173Absent eyebrow (HP:0002223)1.54288281
174Cutaneous syndactyly (HP:0012725)1.54091514
175Alveolar cell carcinoma (HP:0006519)1.53557930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.95122657
2CASK4.20840329
3SIK33.70269024
4LATS13.48500280
5MST1R3.31959711
6STK392.95902917
7CDK82.84667849
8STK38L2.60997195
9MET2.46497680
10EPHB22.36014772
11WNK42.24057371
12ZAK2.21235716
13TRPM72.15544341
14ERBB32.07776459
15DDR22.06099126
16ARAF1.98272366
17PRPF4B1.95647546
18LATS21.89608372
19OXSR11.89164965
20INSRR1.89097455
21TGFBR11.87784094
22MAPK131.81828346
23BRSK21.79762599
24PIK3CA1.70578968
25MAP3K141.69309325
26RIPK11.67924499
27EIF2AK21.62807944
28MAP3K91.58837064
29NTRK31.55125187
30NUAK11.54943263
31TNIK1.53861799
32SIK21.53650060
33PLK21.51186409
34SGK21.45968246
35BMPR1B1.43349146
36PIK3CG1.39621522
37NTRK11.39571889
38MAP2K71.38884831
39PBK1.38395462
40ACVR1B1.33723901
41CAMKK21.33476728
42ADRBK21.33117342
43TAOK21.28157086
44CDK31.26073524
45NEK61.24016684
46TXK1.23726593
47ERBB41.21323024
48BMPR21.20316292
49PRKD21.19878285
50TIE11.19372671
51MAPKAPK31.16239956
52SIK11.15508624
53PINK11.14497586
54ICK1.14170058
55PIM21.12915017
56AKT31.11688684
57EPHA31.11592966
58MKNK21.11539561
59MKNK11.09790258
60YES11.09664194
61STK31.09282648
62TEC1.02963002
63MAPKAPK51.02019877
64TGFBR21.01790225
65TTN1.00345899
66FER0.99998031
67EPHA20.93804977
68BRD40.92401180
69PRKCE0.91688217
70PAK30.91554292
71RAF10.90028748
72PRKD30.87873643
73STK380.87413583
74SGK2230.85998591
75SGK4940.85998591
76FRK0.84740558
77MARK10.82707785
78MUSK0.82396346
79EPHB10.77484579
80MYLK0.75015593
81CDC42BPA0.74141403
82DMPK0.73818865
83SGK30.73519202
84TNK20.70582180
85IRAK30.70148706
86ROCK10.69028066
87PAK20.64369227
88CAMK2A0.63919959
89PTK20.63908577
90NTRK20.63791607
91CLK10.63771622
92MOS0.62949119
93SRPK10.60867604
94CAMK2G0.60682038
95PLK40.60211381
96EEF2K0.59670914
97IKBKB0.58439611
98MELK0.56410297
99MTOR0.56049584
100MARK20.54391156
101MAP3K130.53827839
102PDGFRA0.52863733
103CAMK2B0.52661604
104CAMK1G0.50936277
105PKN10.49994354
106PDGFRB0.49704656
107MAP3K120.48246094
108GRK10.46818593
109PRKG10.46436879
110MAPK120.46363235
111CHEK20.46150560
112INSR0.45763223
113GRK70.45489001
114PRKCH0.45247882
115JAK30.43952605
116SGK10.43787549
117RPS6KA20.43182510
118ADRBK10.42928580
119CDK120.42218838
120WNK10.42020717
121KSR20.41715890
122BRSK10.40952562
123MAPK70.39839040
124EPHA40.38939645
125IRAK40.38133625
126CAMK10.37530317
127TSSK60.36993954
128CHUK0.36913790
129KIT0.36792687
130PTK2B0.35381835
131CAMK40.34840909
132TYRO30.34311527
133MARK30.34215630
134PRKAA10.34073399
135PDPK10.33411090
136PRKAA20.32921423
137AKT10.32843779
138IGF1R0.31942912
139PRKG20.31715249
140CAMK1D0.31640824
141MAP3K40.31390975
142JAK10.30896830
143CSNK1G10.30513491
144MAPK100.30073191
145MAP2K10.28618697
146MAP3K20.25587643
147BRAF0.25511345
148ERBB20.24318334
149STK240.24264891
150RPS6KB10.22249831
151CDK50.22196847
152TTK0.22100911
153FLT30.21446579
154NEK10.20077520
155PIM10.20046731
156STK110.19451461
157CDK90.18358127

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.28247995
2Arginine biosynthesis_Homo sapiens_hsa002202.22290193
3Nicotine addiction_Homo sapiens_hsa050332.08733068
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97068900
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73193547
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66334746
7Malaria_Homo sapiens_hsa051441.62736391
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61816575
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60453377
10Nitrogen metabolism_Homo sapiens_hsa009101.52392473
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51077620
12Dilated cardiomyopathy_Homo sapiens_hsa054141.50869958
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49388676
14Renin secretion_Homo sapiens_hsa049241.49231141
15Focal adhesion_Homo sapiens_hsa045101.48211403
16Axon guidance_Homo sapiens_hsa043601.46578307
17Melanoma_Homo sapiens_hsa052181.42558059
18Taste transduction_Homo sapiens_hsa047421.39201110
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37779083
20Dorso-ventral axis formation_Homo sapiens_hsa043201.36433453
21Serotonergic synapse_Homo sapiens_hsa047261.29753755
22Ovarian steroidogenesis_Homo sapiens_hsa049131.28131975
23TGF-beta signaling pathway_Homo sapiens_hsa043501.26482607
24Rheumatoid arthritis_Homo sapiens_hsa053231.26437833
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23160314
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22749101
27Gap junction_Homo sapiens_hsa045401.20344953
28Fatty acid biosynthesis_Homo sapiens_hsa000611.19394622
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.19005173
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18750827
31Basal cell carcinoma_Homo sapiens_hsa052171.16619549
32MicroRNAs in cancer_Homo sapiens_hsa052061.14638974
33Morphine addiction_Homo sapiens_hsa050321.14514716
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14258995
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13148054
36p53 signaling pathway_Homo sapiens_hsa041151.13046350
37Hippo signaling pathway_Homo sapiens_hsa043901.12662085
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11826060
39Bile secretion_Homo sapiens_hsa049761.08032190
40Phagosome_Homo sapiens_hsa041451.06127108
41Fanconi anemia pathway_Homo sapiens_hsa034601.05888297
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04383781
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03642040
44Wnt signaling pathway_Homo sapiens_hsa043101.02586316
45TNF signaling pathway_Homo sapiens_hsa046681.02418976
46Autoimmune thyroid disease_Homo sapiens_hsa053201.02400022
47Proteoglycans in cancer_Homo sapiens_hsa052051.02042004
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02035549
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.02030174
50Adherens junction_Homo sapiens_hsa045201.01813136
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01304112
52Protein digestion and absorption_Homo sapiens_hsa049740.99690810
53Rap1 signaling pathway_Homo sapiens_hsa040150.98403590
54Glutamatergic synapse_Homo sapiens_hsa047240.96700804
55Small cell lung cancer_Homo sapiens_hsa052220.95715258
56Hematopoietic cell lineage_Homo sapiens_hsa046400.95214477
57Calcium signaling pathway_Homo sapiens_hsa040200.91604999
58Circadian entrainment_Homo sapiens_hsa047130.90647114
59ABC transporters_Homo sapiens_hsa020100.89658008
60Ras signaling pathway_Homo sapiens_hsa040140.89549265
61Amoebiasis_Homo sapiens_hsa051460.87873022
62Renin-angiotensin system_Homo sapiens_hsa046140.86929069
63Gastric acid secretion_Homo sapiens_hsa049710.85768939
64Long-term potentiation_Homo sapiens_hsa047200.85345780
65Hedgehog signaling pathway_Homo sapiens_hsa043400.85266522
66FoxO signaling pathway_Homo sapiens_hsa040680.85043909
67Leishmaniasis_Homo sapiens_hsa051400.85011970
68Shigellosis_Homo sapiens_hsa051310.82366085
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82345225
70Olfactory transduction_Homo sapiens_hsa047400.82288065
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81343677
72ErbB signaling pathway_Homo sapiens_hsa040120.80665061
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80575752
74Sphingolipid metabolism_Homo sapiens_hsa006000.80495882
75Long-term depression_Homo sapiens_hsa047300.80125371
76Dopaminergic synapse_Homo sapiens_hsa047280.79960267
77Amphetamine addiction_Homo sapiens_hsa050310.79307187
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78237879
79Phototransduction_Homo sapiens_hsa047440.77352027
80Bladder cancer_Homo sapiens_hsa052190.77037275
81Vitamin digestion and absorption_Homo sapiens_hsa049770.76403895
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76195981
83cAMP signaling pathway_Homo sapiens_hsa040240.76060108
84Graft-versus-host disease_Homo sapiens_hsa053320.75898952
85Arachidonic acid metabolism_Homo sapiens_hsa005900.75016267
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.74992215
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74909599
88Salivary secretion_Homo sapiens_hsa049700.74023052
89Basal transcription factors_Homo sapiens_hsa030220.73842333
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73285480
91MAPK signaling pathway_Homo sapiens_hsa040100.72696562
92Mineral absorption_Homo sapiens_hsa049780.72270740
93Allograft rejection_Homo sapiens_hsa053300.71643096
94Tight junction_Homo sapiens_hsa045300.71544867
95Cocaine addiction_Homo sapiens_hsa050300.71523429
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71052939
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.70855690
98N-Glycan biosynthesis_Homo sapiens_hsa005100.70728540
99Pathways in cancer_Homo sapiens_hsa052000.70287744
100Cholinergic synapse_Homo sapiens_hsa047250.68863929
101Biosynthesis of amino acids_Homo sapiens_hsa012300.67909964
102Circadian rhythm_Homo sapiens_hsa047100.67585552
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.67426107
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67004413
105Pancreatic cancer_Homo sapiens_hsa052120.66903135
106Oxytocin signaling pathway_Homo sapiens_hsa049210.66858827
107Platelet activation_Homo sapiens_hsa046110.66570786
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66190925
109Prostate cancer_Homo sapiens_hsa052150.64417738
110Measles_Homo sapiens_hsa051620.64031981
111GABAergic synapse_Homo sapiens_hsa047270.62455721
112Cell cycle_Homo sapiens_hsa041100.61855864
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.61533633
114Selenocompound metabolism_Homo sapiens_hsa004500.61078078
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60983355
116Alcoholism_Homo sapiens_hsa050340.60168003
117Arginine and proline metabolism_Homo sapiens_hsa003300.60144240
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.59838016
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59770104
120Oocyte meiosis_Homo sapiens_hsa041140.59709600
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59673341
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59539988
123Thyroid hormone synthesis_Homo sapiens_hsa049180.58983022
124Salmonella infection_Homo sapiens_hsa051320.58980512
125mTOR signaling pathway_Homo sapiens_hsa041500.58711334
126Estrogen signaling pathway_Homo sapiens_hsa049150.58467392
127Inositol phosphate metabolism_Homo sapiens_hsa005620.58012825
128Osteoclast differentiation_Homo sapiens_hsa043800.58004366
129AMPK signaling pathway_Homo sapiens_hsa041520.57681350
130Melanogenesis_Homo sapiens_hsa049160.57673658
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57518699
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57441525
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.56240111
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56102825
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55525398
136Pancreatic secretion_Homo sapiens_hsa049720.55247519
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55016807
138Tuberculosis_Homo sapiens_hsa051520.54444941
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54023076
140Synaptic vesicle cycle_Homo sapiens_hsa047210.53486176
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47854257
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47225596
143Ether lipid metabolism_Homo sapiens_hsa005650.46017674
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45506276
145Glucagon signaling pathway_Homo sapiens_hsa049220.42570297
146Thyroid cancer_Homo sapiens_hsa052160.42460274
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42283057
148Phenylalanine metabolism_Homo sapiens_hsa003600.42143446
149Histidine metabolism_Homo sapiens_hsa003400.40615887

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »