TLL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.80472767
2ensheathment of neurons (GO:0007272)6.79762241
3axon ensheathment (GO:0008366)6.79762241
4myelination (GO:0042552)6.60612135
5myelin maintenance (GO:0043217)5.65977680
6long-chain fatty acid biosynthetic process (GO:0042759)5.58024499
7somite development (GO:0061053)4.90259291
8negative regulation of protein localization to cell surface (GO:2000009)4.79704094
9oligodendrocyte differentiation (GO:0048709)4.79105766
10behavioral response to nicotine (GO:0035095)4.69203632
11presynaptic membrane organization (GO:0097090)4.52943182
12negative regulation of neurotransmitter secretion (GO:0046929)4.49797865
13positive regulation of oligodendrocyte differentiation (GO:0048714)4.46111277
14regulation of gonadotropin secretion (GO:0032276)4.41954322
15creatine metabolic process (GO:0006600)4.36221174
16establishment of mitochondrion localization (GO:0051654)4.35263370
17presynaptic membrane assembly (GO:0097105)4.30819693
18peptidyl-tyrosine autophosphorylation (GO:0038083)4.30397080
19negative regulation of neurotransmitter transport (GO:0051589)4.29268954
20apical protein localization (GO:0045176)4.27256369
21cholesterol biosynthetic process (GO:0006695)4.24389970
22long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.19025714
23eye photoreceptor cell differentiation (GO:0001754)4.14834026
24photoreceptor cell differentiation (GO:0046530)4.14834026
25regulation of collateral sprouting (GO:0048670)4.12720866
26response to pheromone (GO:0019236)3.94656301
27response to redox state (GO:0051775)3.91240856
28membrane tubulation (GO:0097320)3.90692144
29astrocyte development (GO:0014002)3.89013128
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.81745758
31fucose catabolic process (GO:0019317)3.80515426
32L-fucose metabolic process (GO:0042354)3.80515426
33L-fucose catabolic process (GO:0042355)3.80515426
34asymmetric protein localization (GO:0008105)3.78581522
35isoprenoid biosynthetic process (GO:0008299)3.78109265
36amyloid precursor protein metabolic process (GO:0042982)3.75804561
37fatty-acyl-CoA biosynthetic process (GO:0046949)3.74966998
38response to lipoprotein particle (GO:0055094)3.71906827
39adhesion of symbiont to host cell (GO:0044650)3.71729923
40virion attachment to host cell (GO:0019062)3.71729923
41neuron remodeling (GO:0016322)3.70573113
42behavioral response to ethanol (GO:0048149)3.70053827
43long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.69826954
44sterol biosynthetic process (GO:0016126)3.67627040
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63203788
46gamma-aminobutyric acid transport (GO:0015812)3.60579150
47enteric nervous system development (GO:0048484)3.59175203
48protein palmitoylation (GO:0018345)3.54935892
49negative regulation of T cell differentiation in thymus (GO:0033085)3.52656313
50indolalkylamine metabolic process (GO:0006586)3.40364318
51myelination in peripheral nervous system (GO:0022011)3.39750701
52peripheral nervous system axon ensheathment (GO:0032292)3.39750701
53neuron cell-cell adhesion (GO:0007158)3.35898644
54platelet dense granule organization (GO:0060155)3.35790513
55photoreceptor cell maintenance (GO:0045494)3.34704684
56negative regulation of telomere maintenance (GO:0032205)3.34242418
57neuronal action potential propagation (GO:0019227)3.33377016
58limb bud formation (GO:0060174)3.33161293
59glycerophospholipid catabolic process (GO:0046475)3.33049879
60protein polyglutamylation (GO:0018095)3.30077680
61substantia nigra development (GO:0021762)3.28005286
62negative regulation of axonogenesis (GO:0050771)3.26629134
63fatty-acyl-CoA metabolic process (GO:0035337)3.24600183
64water-soluble vitamin biosynthetic process (GO:0042364)3.24371381
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21677296
66acyl-CoA biosynthetic process (GO:0071616)3.19502626
67thioester biosynthetic process (GO:0035384)3.19502626
68heme transport (GO:0015886)3.18802535
69cellular ketone body metabolic process (GO:0046950)3.18740704
70kynurenine metabolic process (GO:0070189)3.14159559
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.09045241
72L-phenylalanine catabolic process (GO:0006559)3.09045241
73peripheral nervous system development (GO:0007422)3.08109996
74regulation of cilium movement (GO:0003352)3.07890782
75axoneme assembly (GO:0035082)3.05910957
76negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04704579
77negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.04024205
78glycosylceramide metabolic process (GO:0006677)3.02727070
79adult walking behavior (GO:0007628)3.01639214
80indole-containing compound catabolic process (GO:0042436)3.01584792
81indolalkylamine catabolic process (GO:0046218)3.01584792
82tryptophan catabolic process (GO:0006569)3.01584792
83cilium morphogenesis (GO:0060271)3.00511389
84DNA double-strand break processing (GO:0000729)3.00290461
85axon development (GO:0061564)2.98845656
86estrogen biosynthetic process (GO:0006703)2.97907625
87glycine transport (GO:0015816)2.96841506
88C4-dicarboxylate transport (GO:0015740)2.95800301
89detection of light stimulus involved in sensory perception (GO:0050962)2.94607140
90detection of light stimulus involved in visual perception (GO:0050908)2.94607140
91response to methylmercury (GO:0051597)2.94101493
92regulation of hippo signaling (GO:0035330)2.93592188
93L-amino acid import (GO:0043092)2.93020425
94iron coordination entity transport (GO:1901678)2.92845397
95cellular response to epinephrine stimulus (GO:0071872)2.92115963
96replication fork processing (GO:0031297)2.91996480
97very long-chain fatty acid metabolic process (GO:0000038)2.91953877
98ketone body metabolic process (GO:1902224)2.88917284
99reciprocal meiotic recombination (GO:0007131)2.87929571
100reciprocal DNA recombination (GO:0035825)2.87929571
101cerebral cortex radially oriented cell migration (GO:0021799)2.87020672
102negative regulation of axon extension (GO:0030517)2.86463668
103piRNA metabolic process (GO:0034587)2.86295230
104adaptation of signaling pathway (GO:0023058)2.86141336
105peptidyl-cysteine modification (GO:0018198)2.85189991
106epithelial cilium movement (GO:0003351)2.85042541
107negative regulation of JUN kinase activity (GO:0043508)2.84230841
108regulation of lipoprotein metabolic process (GO:0050746)2.83495693
109glycosphingolipid biosynthetic process (GO:0006688)2.82914823
110cornea development in camera-type eye (GO:0061303)2.82339591
111adhesion of symbiont to host (GO:0044406)2.82025547
112regulation of nuclear cell cycle DNA replication (GO:0033262)2.81634363
113tryptophan metabolic process (GO:0006568)2.81061453
114cellular response to monoamine stimulus (GO:0071868)2.80774327
115cellular response to catecholamine stimulus (GO:0071870)2.80774327
116mannosylation (GO:0097502)2.80381400
117positive regulation of glial cell differentiation (GO:0045687)2.80352131
118protein-cofactor linkage (GO:0018065)2.79436458
119ubiquinone metabolic process (GO:0006743)2.78441666
120ear development (GO:0043583)2.78320432
121regulation of somitogenesis (GO:0014807)2.77056618
122nonmotile primary cilium assembly (GO:0035058)2.75711521
123microtubule polymerization or depolymerization (GO:0031109)2.73777875
124GPI anchor metabolic process (GO:0006505)2.73610647
125reflex (GO:0060004)2.73535967
126ubiquinone biosynthetic process (GO:0006744)2.73237462
127protein K11-linked deubiquitination (GO:0035871)2.73194496
128DNA deamination (GO:0045006)2.72243826
129pyrimidine nucleobase catabolic process (GO:0006208)2.71427964
130proline transport (GO:0015824)2.71058970
131positive regulation of cellular amine metabolic process (GO:0033240)2.70986691
132import into cell (GO:0098657)2.69674021
133peptidyl-histidine modification (GO:0018202)2.68977933
134glial cell development (GO:0021782)2.66983632
135cellular response to leptin stimulus (GO:0044320)2.66750534
136amyloid precursor protein catabolic process (GO:0042987)2.65946485
137preassembly of GPI anchor in ER membrane (GO:0016254)2.65368543
138recombinational repair (GO:0000725)2.65300173
139cyclic nucleotide catabolic process (GO:0009214)2.64912785
140neuronal action potential (GO:0019228)2.64205708
141positive regulation of action potential (GO:0045760)2.64200876
142membrane assembly (GO:0071709)2.64001991
143double-strand break repair via homologous recombination (GO:0000724)2.63657117
144positive regulation of gliogenesis (GO:0014015)2.63524583
145magnesium ion transport (GO:0015693)2.62779445
146indole-containing compound metabolic process (GO:0042430)2.61422401
147detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.58178862
148detection of temperature stimulus involved in sensory perception (GO:0050961)2.58178862
149respiratory chain complex IV assembly (GO:0008535)2.56110868
150cilium organization (GO:0044782)2.56018747
151glial cell differentiation (GO:0010001)2.55367032
152transmission of nerve impulse (GO:0019226)2.54903161
153dopamine transport (GO:0015872)2.54327153
154startle response (GO:0001964)2.53197115
155cilium or flagellum-dependent cell motility (GO:0001539)2.50522364
156negative regulation of systemic arterial blood pressure (GO:0003085)2.50435490
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50387734
158auditory receptor cell stereocilium organization (GO:0060088)2.50315529
159positive regulation of T cell differentiation in thymus (GO:0033089)2.49949737
160positive regulation of mitochondrial fission (GO:0090141)2.49853333
161intraciliary transport (GO:0042073)2.48913250
162cilium assembly (GO:0042384)2.48348937
163regulation of neurotransmitter uptake (GO:0051580)2.47795246
164retinal cone cell development (GO:0046549)2.47612342
165GPI anchor biosynthetic process (GO:0006506)2.46856833
166pancreas development (GO:0031016)2.46649309
167meiotic chromosome segregation (GO:0045132)2.46178401
168protein localization to endosome (GO:0036010)2.46024438
169negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45844437
170membrane raft organization (GO:0031579)2.45777817
171response to monoamine (GO:0071867)2.45676609
172response to catecholamine (GO:0071869)2.45676609
173neural tube formation (GO:0001841)2.45008020
174detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44961367
175regulation of meiosis I (GO:0060631)2.44651617
176response to lead ion (GO:0010288)2.44250504
177negative regulation of acute inflammatory response (GO:0002674)2.44237051
178cellular response to ATP (GO:0071318)2.44184916
179erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43117206
180L-phenylalanine metabolic process (GO:0006558)2.43117206
181sex determination (GO:0007530)2.43061091
182cilium movement (GO:0003341)2.42005690
183seminiferous tubule development (GO:0072520)2.41295363
184protein complex biogenesis (GO:0070271)2.40134571
185regulation of telomere maintenance (GO:0032204)2.38612035
186protein localization to cilium (GO:0061512)2.38534227
187mitochondrial respiratory chain complex I assembly (GO:0032981)2.35887340
188NADH dehydrogenase complex assembly (GO:0010257)2.35887340
189mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.35887340
190regulation of action potential (GO:0098900)2.35803113
191photoreceptor cell development (GO:0042461)2.35510266
192resolution of meiotic recombination intermediates (GO:0000712)2.35369932
193amine catabolic process (GO:0009310)2.34715446
194cellular biogenic amine catabolic process (GO:0042402)2.34715446
195DNA methylation involved in gamete generation (GO:0043046)2.34692479
196inner ear receptor stereocilium organization (GO:0060122)2.34499276
197axon ensheathment in central nervous system (GO:0032291)11.7401166
198central nervous system myelination (GO:0022010)11.7401166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.57853126
2VDR_22108803_ChIP-Seq_LS180_Human3.43645482
3EZH2_22144423_ChIP-Seq_EOC_Human3.40101249
4GBX2_23144817_ChIP-Seq_PC3_Human3.24610153
5IGF1R_20145208_ChIP-Seq_DFB_Human2.97903141
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77603058
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73829294
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65529472
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51510880
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51510880
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.43213456
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40537121
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.33373597
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33343209
15TAF15_26573619_Chip-Seq_HEK293_Human2.31845793
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.27670966
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.24561122
18EWS_26573619_Chip-Seq_HEK293_Human2.20506565
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.19533357
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.17937906
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16417624
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14814971
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10817531
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06704471
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03900922
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97298432
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97072365
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94681933
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91574402
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.85217940
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85087390
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84007678
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81647415
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81336470
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.79884619
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78965745
37AR_21572438_ChIP-Seq_LNCaP_Human1.78298985
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74784818
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71846070
40DROSHA_22980978_ChIP-Seq_HELA_Human1.70651640
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68382631
42* CBP_20019798_ChIP-Seq_JUKART_Human1.65439991
43* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65439991
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63318062
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62015382
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60202494
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.57235051
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.56967802
49AR_25329375_ChIP-Seq_VCAP_Human1.54590007
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.52903891
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52411247
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51653210
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50922080
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48268830
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47627130
56TP53_22573176_ChIP-Seq_HFKS_Human1.45338966
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44326312
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43046773
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43046773
60BCAT_22108803_ChIP-Seq_LS180_Human1.41034933
61TCF4_22108803_ChIP-Seq_LS180_Human1.40619371
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40454994
63ER_23166858_ChIP-Seq_MCF-7_Human1.40078067
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.39687112
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38312069
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.36120156
67* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35131985
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34793621
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.34087783
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33972159
71* RUNX2_22187159_ChIP-Seq_PCA_Human1.33494483
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.32657941
73IRF1_19129219_ChIP-ChIP_H3396_Human1.31661015
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28952431
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27595361
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27595361
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27595172
78FUS_26573619_Chip-Seq_HEK293_Human1.25568957
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.24930492
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24234537
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.22910436
82* REST_21632747_ChIP-Seq_MESCs_Mouse1.19681279
83MYC_18940864_ChIP-ChIP_HL60_Human1.19103174
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.18989855
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.18665235
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16536347
87KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15559002
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15144240
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14201176
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14014499
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13981118
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.12413127
93* P300_19829295_ChIP-Seq_ESCs_Human1.12409401
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10371390
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09768037
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.09733311
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09547255
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09072019
99CDX2_22108803_ChIP-Seq_LS180_Human1.07576263
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07129165
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.06592910
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06592910
103AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05742040
104HOXB7_26014856_ChIP-Seq_BT474_Human1.05082814
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.03960565
106SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03957817
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03841126
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.02924117
109P53_22387025_ChIP-Seq_ESCs_Mouse1.02686526
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02595171
111AR_20517297_ChIP-Seq_VCAP_Human1.01780313
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.00543285
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00453794
114EOMES_21245162_ChIP-Seq_HESCs_Human1.00364281
115TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99848808
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.99729315
117* REST_18959480_ChIP-ChIP_MESCs_Mouse0.99040716
118RNF2_27304074_Chip-Seq_NSC_Mouse0.98118373
119* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97523704
120* NCOR_22424771_ChIP-Seq_293T_Human0.96490282
121STAT3_18555785_Chip-Seq_ESCs_Mouse0.95521061
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95464311
123* GATA3_21878914_ChIP-Seq_MCF-7_Human0.95386865
124TP53_18474530_ChIP-ChIP_U2OS_Human0.95248497
125SMAD4_21799915_ChIP-Seq_A2780_Human0.95227636
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94161016
127HTT_18923047_ChIP-ChIP_STHdh_Human0.94018422
128EST1_17652178_ChIP-ChIP_JURKAT_Human0.93919084
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93757266
130STAT3_23295773_ChIP-Seq_U87_Human0.92251467
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92228494
132SOX2_19829295_ChIP-Seq_ESCs_Human0.92221203
133NANOG_19829295_ChIP-Seq_ESCs_Human0.92221203
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90882210
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90278736
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.89061828
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88963456
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88948065
139TCF4_23295773_ChIP-Seq_U87_Human0.88508881
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88298489
141AHR_22903824_ChIP-Seq_MCF-7_Human0.87720863
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.87512204
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87417975
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87284250
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.86208240
146* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85993117
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85783912
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85423788
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.85061071
150* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84068784
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.83815872
152SOX2_16153702_ChIP-ChIP_HESCs_Human0.83789826
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83419125
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83162218
155TP53_16413492_ChIP-PET_HCT116_Human0.82297282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.49688511
2MP0003880_abnormal_central_pattern4.48696710
3MP0004270_analgesia3.66883801
4MP0005171_absent_coat_pigmentation3.45705112
5MP0003950_abnormal_plasma_membrane3.12059717
6MP0008877_abnormal_DNA_methylation2.96565752
7MP0003136_yellow_coat_color2.74518367
8MP0001529_abnormal_vocalization2.73447788
9MP0006292_abnormal_olfactory_placode2.70588074
10MP0003329_amyloid_beta_deposits2.60909492
11MP0001486_abnormal_startle_reflex2.60679845
12MP0002102_abnormal_ear_morphology2.52940481
13MP0002272_abnormal_nervous_system2.50105884
14MP0004859_abnormal_synaptic_plasticity2.47049958
15MP0003690_abnormal_glial_cell2.44418951
16MP0004885_abnormal_endolymph2.30294702
17MP0000778_abnormal_nervous_system2.28922571
18MP0003787_abnormal_imprinting2.26756648
19MP0003634_abnormal_glial_cell2.24091355
20MP0004742_abnormal_vestibular_system2.15630409
21MP0005410_abnormal_fertilization2.13434876
22MP0002064_seizures2.08216039
23MP0005646_abnormal_pituitary_gland2.08102012
24MP0001905_abnormal_dopamine_level2.07180996
25MP0004142_abnormal_muscle_tone2.03001743
26MP0002876_abnormal_thyroid_physiology2.00855856
27MP0005409_darkened_coat_color1.96574888
28MP0002734_abnormal_mechanical_nocicepti1.94045022
29MP0001485_abnormal_pinna_reflex1.93286397
30MP0005253_abnormal_eye_physiology1.81302520
31MP0003646_muscle_fatigue1.80820056
32MP0009046_muscle_twitch1.80799660
33MP0002638_abnormal_pupillary_reflex1.78835260
34MP0003635_abnormal_synaptic_transmissio1.78167670
35MP0004381_abnormal_hair_follicle1.72427086
36MP0006276_abnormal_autonomic_nervous1.72141188
37MP0002229_neurodegeneration1.67524311
38MP0004043_abnormal_pH_regulation1.65513053
39MP0008438_abnormal_cutaneous_collagen1.65196510
40MP0000631_abnormal_neuroendocrine_gland1.62745325
41MP0009745_abnormal_behavioral_response1.62391698
42MP0008875_abnormal_xenobiotic_pharmacok1.62042325
43MP0003632_abnormal_nervous_system1.61849861
44MP0008872_abnormal_physiological_respon1.61711630
45MP0000955_abnormal_spinal_cord1.56475963
46MP0000427_abnormal_hair_cycle1.54963466
47MP0003122_maternal_imprinting1.49981500
48MP0000462_abnormal_digestive_system1.48882328
49MP0004147_increased_porphyrin_level1.48405570
50MP0005423_abnormal_somatic_nervous1.45151950
51MP0005645_abnormal_hypothalamus_physiol1.43882399
52MP0001984_abnormal_olfaction1.43517783
53MP0003806_abnormal_nucleotide_metabolis1.42605739
54MP0000747_muscle_weakness1.42001348
55MP0000372_irregular_coat_pigmentation1.40609905
56MP0010678_abnormal_skin_adnexa1.39708794
57MP0000604_amyloidosis1.38446857
58MP0001501_abnormal_sleep_pattern1.38021398
59MP0001986_abnormal_taste_sensitivity1.37599201
60MP0008995_early_reproductive_senescence1.37333579
61MP0002572_abnormal_emotion/affect_behav1.36265916
62MP0002882_abnormal_neuron_morphology1.34419695
63MP0004134_abnormal_chest_morphology1.33269401
64MP0003011_delayed_dark_adaptation1.32748223
65MP0002234_abnormal_pharynx_morphology1.30825602
66MP0000569_abnormal_digit_pigmentation1.26740576
67MP0003121_genomic_imprinting1.26368183
68MP0002066_abnormal_motor_capabilities/c1.22205202
69MP0001970_abnormal_pain_threshold1.21490709
70MP0001346_abnormal_lacrimal_gland1.21123072
71MP0003631_nervous_system_phenotype1.20843246
72MP0000751_myopathy1.20641281
73MP0000383_abnormal_hair_follicle1.20025242
74MP0005623_abnormal_meninges_morphology1.19710597
75MP0004215_abnormal_myocardial_fiber1.19392218
76MP0002063_abnormal_learning/memory/cond1.17393798
77MP0005551_abnormal_eye_electrophysiolog1.16048067
78MP0002752_abnormal_somatic_nervous1.14869905
79MP0001968_abnormal_touch/_nociception1.14221645
80MP0002160_abnormal_reproductive_system1.13584957
81MP0000762_abnormal_tongue_morphology1.12420423
82MP0003718_maternal_effect1.12083038
83MP0004036_abnormal_muscle_relaxation1.11604194
84MP0008789_abnormal_olfactory_epithelium1.10212767
85MP0002557_abnormal_social/conspecific_i1.09149468
86MP0001440_abnormal_grooming_behavior1.08691948
87MP0003937_abnormal_limbs/digits/tail_de1.08629127
88MP0002295_abnormal_pulmonary_circulatio1.08612216
89MP0003195_calcinosis1.08573406
90MP0008569_lethality_at_weaning1.07075509
91MP0001963_abnormal_hearing_physiology1.06738666
92MP0004145_abnormal_muscle_electrophysio1.04650559
93MP0008775_abnormal_heart_ventricle1.04218315
94MP0004924_abnormal_behavior1.04102901
95MP0005386_behavior/neurological_phenoty1.04102901
96MP0001324_abnormal_eye_pigmentation1.02294248
97MP0001661_extended_life_span1.01757514
98MP0005391_vision/eye_phenotype1.01594403
99MP0001348_abnormal_lacrimal_gland1.01542809
100MP0002067_abnormal_sensory_capabilities1.01176220
101MP0003698_abnormal_male_reproductive1.00892792
102MP0000467_abnormal_esophagus_morphology0.98597913
103MP0002928_abnormal_bile_duct0.98505038
104MP0008260_abnormal_autophagy0.97901703
105MP0005408_hypopigmentation0.97894949
106MP0003283_abnormal_digestive_organ0.97848723
107MP0008058_abnormal_DNA_repair0.97697453
108MP0003567_abnormal_fetal_cardiomyocyte0.96224808
109MP0002653_abnormal_ependyma_morphology0.96026164
110MP0002733_abnormal_thermal_nociception0.95943952
111MP0003633_abnormal_nervous_system0.95379644
112MP0005389_reproductive_system_phenotype0.93507752
113MP0003938_abnormal_ear_development0.93353546
114MP0000749_muscle_degeneration0.92397197
115MP0001299_abnormal_eye_distance/0.90665804
116MP0008057_abnormal_DNA_replication0.90426377
117MP0001929_abnormal_gametogenesis0.89834580
118MP0002210_abnormal_sex_determination0.89223491
119MP0009697_abnormal_copulation0.89049938
120MP0001502_abnormal_circadian_rhythm0.87106809
121MP0001293_anophthalmia0.85994996
122MP0000653_abnormal_sex_gland0.85563202
123MP0005084_abnormal_gallbladder_morpholo0.84830325
124MP0001764_abnormal_homeostasis0.84533999
125MP0000049_abnormal_middle_ear0.84205581
126MP0003137_abnormal_impulse_conducting0.84202296
127MP0002736_abnormal_nociception_after0.83772601
128MP0005195_abnormal_posterior_eye0.83674634
129MP0005174_abnormal_tail_pigmentation0.81736801
130MP0003119_abnormal_digestive_system0.81608232
131MP0000647_abnormal_sebaceous_gland0.81159073
132MP0001145_abnormal_male_reproductive0.80520594
133MP0000579_abnormal_nail_morphology0.80483958
134MP0005647_abnormal_sex_gland0.79041554
135MP0006082_CNS_inflammation0.78446108
136MP0002152_abnormal_brain_morphology0.76943696
137MP0005332_abnormal_amino_acid0.76114198
138MP0000230_abnormal_systemic_arterial0.75537131
139MP0004811_abnormal_neuron_physiology0.75114718
140MP0005451_abnormal_body_composition0.74827432
141MP0004085_abnormal_heartbeat0.74486261
142MP0000538_abnormal_urinary_bladder0.74429131
143MP0000026_abnormal_inner_ear0.73914514
144MP0002837_dystrophic_cardiac_calcinosis0.73389776
145MP0002751_abnormal_autonomic_nervous0.72765735
146MP0002184_abnormal_innervation0.72638908
147MP0002933_joint_inflammation0.72266603
148MP0004185_abnormal_adipocyte_glucose0.70801123
149MP0006072_abnormal_retinal_apoptosis0.70648707
150MP0001851_eye_inflammation0.70556548
151MP0002735_abnormal_chemical_nociception0.66290057
152MP0000639_abnormal_adrenal_gland0.65562255
153MP0009840_abnormal_foam_cell0.65292128
154MP0002938_white_spotting0.64588717
155MP0004272_abnormal_basement_membrane0.64238495
156MP0004133_heterotaxia0.62666615
157MP0009780_abnormal_chondrocyte_physiolo0.62509017

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.68205627
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.68205627
3Neurofibrillary tangles (HP:0002185)6.58186688
4Abnormality of the corticospinal tract (HP:0002492)5.18075820
5Cerebral inclusion bodies (HP:0100314)4.86182576
6Peripheral hypomyelination (HP:0007182)4.79251271
7Termporal pattern (HP:0011008)4.22525391
8Insidious onset (HP:0003587)4.22525391
9Pancreatic cysts (HP:0001737)4.16781714
10Pancreatic fibrosis (HP:0100732)3.99741010
11Onion bulb formation (HP:0003383)3.89976264
12True hermaphroditism (HP:0010459)3.84618025
13Sensory axonal neuropathy (HP:0003390)3.79183142
14Alacrima (HP:0000522)3.72996732
15Increased serum pyruvate (HP:0003542)3.72152551
16Abnormality of glycolysis (HP:0004366)3.72152551
17Nephronophthisis (HP:0000090)3.69928144
18Cerebral hypomyelination (HP:0006808)3.68477628
19Aplasia/Hypoplasia of the tibia (HP:0005772)3.66770808
20Supranuclear gaze palsy (HP:0000605)3.62057344
21Molar tooth sign on MRI (HP:0002419)3.52840343
22Abnormality of midbrain morphology (HP:0002418)3.52840343
23Spastic gait (HP:0002064)3.47505110
24Ankle clonus (HP:0011448)3.34279665
25Short tibia (HP:0005736)3.30677087
26Abnormality of the renal medulla (HP:0100957)3.30672223
27Muscle fiber splitting (HP:0003555)3.29282532
28Congenital stationary night blindness (HP:0007642)3.28750478
29Dysmetria (HP:0001310)3.24538580
30Parakeratosis (HP:0001036)3.17431610
31Abnormal auditory evoked potentials (HP:0006958)3.16829210
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.13046434
33Medial flaring of the eyebrow (HP:0010747)3.11200174
34Cerebral hemorrhage (HP:0001342)3.03993581
35Chronic hepatic failure (HP:0100626)2.95280244
36Myokymia (HP:0002411)2.93250191
37Anteriorly placed anus (HP:0001545)2.91820243
38Abnormality of the renal cortex (HP:0011035)2.88387447
39Hypoplasia of the iris (HP:0007676)2.85656008
40Pheochromocytoma (HP:0002666)2.84166719
41Attenuation of retinal blood vessels (HP:0007843)2.81858282
42Decreased lacrimation (HP:0000633)2.81513403
43Cystic liver disease (HP:0006706)2.81003835
44Leukodystrophy (HP:0002415)2.80730600
45Type II lissencephaly (HP:0007260)2.80604545
46Segmental peripheral demyelination/remyelination (HP:0003481)2.79839793
47Pendular nystagmus (HP:0012043)2.71884665
48Scanning speech (HP:0002168)2.71018805
49Tubular atrophy (HP:0000092)2.64608593
50Foot dorsiflexor weakness (HP:0009027)2.63417138
51Intention tremor (HP:0002080)2.62267334
52Hyporeflexia of lower limbs (HP:0002600)2.60318528
53Thickened helices (HP:0000391)2.58521098
54Retinal dysplasia (HP:0007973)2.56834741
55Male pseudohermaphroditism (HP:0000037)2.56307681
56Sclerocornea (HP:0000647)2.55598979
57Clumsiness (HP:0002312)2.54887577
58Gait imbalance (HP:0002141)2.54465074
59Spastic paraparesis (HP:0002313)2.53816450
60Congenital primary aphakia (HP:0007707)2.52444607
61Abnormality of the foot musculature (HP:0001436)2.50059960
62Polydipsia (HP:0001959)2.48014159
63Abnormal drinking behavior (HP:0030082)2.48014159
64Abolished electroretinogram (ERG) (HP:0000550)2.46929924
65Stridor (HP:0010307)2.46515875
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.46199875
67White forelock (HP:0002211)2.46135311
68Spastic tetraparesis (HP:0001285)2.45489338
69Absent septum pellucidum (HP:0001331)2.42026264
70Abnormal rod and cone electroretinograms (HP:0008323)2.41887530
71Gaze-evoked nystagmus (HP:0000640)2.41490588
72Gonadotropin excess (HP:0000837)2.40177995
73Absent speech (HP:0001344)2.37131590
74Nephrogenic diabetes insipidus (HP:0009806)2.37068131
75Patchy hypopigmentation of hair (HP:0011365)2.33724149
76Abnormality of the labia minora (HP:0012880)2.32290680
77CNS hypomyelination (HP:0003429)2.32135992
78Hypoplastic iliac wings (HP:0002866)2.31613634
79Decreased motor nerve conduction velocity (HP:0003431)2.29040495
80Hypoplastic pelvis (HP:0008839)2.28452959
81Broad-based gait (HP:0002136)2.28227365
82Akinesia (HP:0002304)2.27502468
83Chorioretinal atrophy (HP:0000533)2.27166529
84Lower limb muscle weakness (HP:0007340)2.27005915
85Abnormality of the proximal phalanges of the hand (HP:0009834)2.24408756
86Postaxial foot polydactyly (HP:0001830)2.21799097
87Methylmalonic acidemia (HP:0002912)2.20014136
88Genital tract atresia (HP:0001827)2.19857645
89Slow saccadic eye movements (HP:0000514)2.19711824
90Optic nerve hypoplasia (HP:0000609)2.17801941
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16691334
92Abnormality of the 1st metacarpal (HP:0010009)2.16650123
93Colon cancer (HP:0003003)2.15917302
94Partial agenesis of the corpus callosum (HP:0001338)2.15857584
95Polyuria (HP:0000103)2.15775862
96Premature skin wrinkling (HP:0100678)2.15052037
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14487527
98Abnormality of alanine metabolism (HP:0010916)2.14487527
99Hyperalaninemia (HP:0003348)2.14487527
100Action tremor (HP:0002345)2.12545534
101Neuroendocrine neoplasm (HP:0100634)2.12417774
102Hemiparesis (HP:0001269)2.11382196
103Megalencephaly (HP:0001355)2.11188404
104Gonadal dysgenesis (HP:0000133)2.10493483
105Morphological abnormality of the inner ear (HP:0011390)2.10168846
106Hypoplasia of the uterus (HP:0000013)2.09677878
107Coronal craniosynostosis (HP:0004440)2.09572668
108Paraparesis (HP:0002385)2.08969290
109Febrile seizures (HP:0002373)2.08567912
110Atonic seizures (HP:0010819)2.08544017
111Anencephaly (HP:0002323)2.08479405
112Decreased central vision (HP:0007663)2.08287967
113Peripheral demyelination (HP:0011096)2.07835064
114Lissencephaly (HP:0001339)2.07605194
115Cerebellar dysplasia (HP:0007033)2.06627484
116Congenital ichthyosiform erythroderma (HP:0007431)2.05928754
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04729719
118Infantile muscular hypotonia (HP:0008947)2.03680510
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03313709
120Urinary urgency (HP:0000012)2.03134100
121Split foot (HP:0001839)2.02943722
122Thyroid-stimulating hormone excess (HP:0002925)2.00769692
123Bowel incontinence (HP:0002607)2.00643300
124Hypoplasia of the pons (HP:0012110)1.99912218
125Congenital hepatic fibrosis (HP:0002612)1.99740283
126Clonus (HP:0002169)1.97682743
127Abnormality of the septum pellucidum (HP:0007375)1.97509950
128Inability to walk (HP:0002540)1.97219505
129Increased corneal curvature (HP:0100692)1.96933154
130Keratoconus (HP:0000563)1.96933154
131Abnormality of macular pigmentation (HP:0008002)1.95912174
132Axonal loss (HP:0003447)1.95906012
133Absent/shortened dynein arms (HP:0200106)1.95853208
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.95853208
135Abnormality of the pons (HP:0007361)1.95345465
136Stomach cancer (HP:0012126)1.94801085
137Hammertoe (HP:0001765)1.94624355
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93099927
139Renal cortical cysts (HP:0000803)1.92769238
140Hepatosplenomegaly (HP:0001433)1.92657636
141Morphological abnormality of the pyramidal tract (HP:0002062)1.92579408
142Poor coordination (HP:0002370)1.91243555
143Hyperglycinemia (HP:0002154)1.88051188
144Epileptic encephalopathy (HP:0200134)1.87893628
145Large for gestational age (HP:0001520)1.87697860
146Aplasia/hypoplasia of the uterus (HP:0008684)1.87437672
147Bile duct proliferation (HP:0001408)1.86641160
148Abnormal biliary tract physiology (HP:0012439)1.86641160
149Postaxial hand polydactyly (HP:0001162)1.85357120
150Furrowed tongue (HP:0000221)1.84599719
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.84332720
152Progressive cerebellar ataxia (HP:0002073)1.83877936
1533-Methylglutaconic aciduria (HP:0003535)1.83303748
154Hypothermia (HP:0002045)1.82290679
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82000483
156Abnormal large intestine physiology (HP:0012700)1.81670820
157Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.81414349
158Conical tooth (HP:0000698)1.81009303
159Muscle hypertrophy of the lower extremities (HP:0008968)1.80930243
160Buphthalmos (HP:0000557)1.80406847
161Urinary incontinence (HP:0000020)1.80122257
162Septo-optic dysplasia (HP:0100842)1.80023042
163Choroideremia (HP:0001139)1.79450090
164Bony spicule pigmentary retinopathy (HP:0007737)1.79167336
165Abnormality of the middle phalanges of the toes (HP:0010183)1.78953253
166Hypoproteinemia (HP:0003075)1.78711206
167Short hallux (HP:0010109)1.77927900
168Tubulointerstitial nephritis (HP:0001970)1.77158972
169Aplasia/Hypoplasia of the hallux (HP:0008362)1.77153544
170Methylmalonic aciduria (HP:0012120)1.76272336
171Generalized myoclonic seizures (HP:0002123)1.76215687
172Focal seizures (HP:0007359)1.76159418
173Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75343567
174Hypophosphatemic rickets (HP:0004912)1.74515252
175Renal Fanconi syndrome (HP:0001994)1.74472556
176Blue irides (HP:0000635)1.74245613
177Focal motor seizures (HP:0011153)1.73415052
178Symphalangism affecting the phalanges of the hand (HP:0009773)1.72608129
179Gowers sign (HP:0003391)1.72073602
180Hyperglycinuria (HP:0003108)1.72034341
181Partial duplication of thumb phalanx (HP:0009944)1.71303394
182Septate vagina (HP:0001153)1.70359048
183Progressive inability to walk (HP:0002505)1.70300422
184Vaginal atresia (HP:0000148)1.69781294
185Choreoathetosis (HP:0001266)1.69290496
186Protruding tongue (HP:0010808)1.69254244
187Slow progression (HP:0003677)1.69188574
188Hyperventilation (HP:0002883)1.68190090
189Abnormality of glycine metabolism (HP:0010895)1.67971806
190Abnormality of serine family amino acid metabolism (HP:0010894)1.67971806
191Distal sensory impairment (HP:0002936)1.67737650
192Intestinal atresia (HP:0011100)1.67480018
193Astigmatism (HP:0000483)1.67241515
194Increased circulating renin level (HP:0000848)1.66509136
195Premature rupture of membranes (HP:0001788)1.66062612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.64845956
2FRK5.55786001
3OXSR14.32339763
4CDK193.20242508
5PINK12.98933318
6PKN12.94199321
7MAP4K22.84348355
8WNK32.61600989
9NUAK12.61416412
10ZAK2.57175260
11EPHB12.55079431
12WNK42.53947031
13BCR2.44266848
14MET2.42178041
15LIMK12.39765446
16ADRBK22.39147586
17PNCK2.34448390
18PBK2.34220947
19EPHA42.32202336
20WNK12.17187281
21FGFR22.05272585
22PRPF4B2.04590793
23CSNK1A1L2.02005310
24CSNK1G31.99058650
25ACVR1B1.93308092
26TESK21.89065174
27UHMK11.84706541
28INSRR1.84331715
29CASK1.81025934
30GRK11.80248501
31CAMK2B1.65925358
32MKNK21.64864411
33PAK61.62853170
34ICK1.62167881
35NTRK11.62046447
36NEK61.61992018
37MAPK131.61374085
38STK38L1.54556433
39TRIM281.54531285
40CSNK1G11.54165774
41CSNK1G21.50948690
42MST41.41824593
43MUSK1.40339075
44ROCK21.34441611
45MAP3K41.33206704
46CAMK2D1.32910460
47CLK11.27911401
48FGR1.23292117
49TYRO31.17417353
50MARK11.15577240
51PLK41.15219004
52TAOK31.14496338
53TLK11.12312143
54TAF11.09148749
55TGFBR11.07155610
56TRPM71.05376950
57SGK2231.05332769
58SGK4941.05332769
59BRSK21.03718025
60CDK141.03510688
61MKNK11.01986409
62PIK3CA0.98856732
63ADRBK10.97895811
64VRK10.97392326
65PDPK10.96988102
66CDK150.96457653
67MAPKAPK50.95429542
68PHKG20.95239420
69PHKG10.95239420
70CDK50.93611711
71CDK180.90239481
72CAMK2G0.90045086
73NTRK30.89085629
74PRKCG0.85541134
75CDK11A0.85205759
76MAP2K70.84530835
77PAK30.83933008
78TNIK0.83577074
79PLK30.82586058
80CAMKK20.82051530
81MAP3K90.77489110
82CAMK1G0.76882858
83EIF2AK30.76646040
84CAMK2A0.76596111
85ERBB30.75507340
86BLK0.75136302
87MELK0.72862649
88FLT30.70818907
89WEE10.70763571
90DYRK20.70264197
91MAP3K130.68975738
92MARK20.67058995
93PRKCE0.64794202
94VRK20.63524254
95KSR20.61540811
96FER0.60662704
97MAPK150.60413939
98BMPR1B0.59041836
99STK110.59040817
100FYN0.58807865
101PRKD10.57739470
102PIK3CG0.57167703
103PRKG10.56758188
104NLK0.56137813
105PDK10.55917899
106CAMK1D0.55836296
107PRKCQ0.55349983
108RPS6KA50.54575338
109ARAF0.54240768
110ERBB40.54170804
111NTRK20.53746105
112LATS10.52743775
113PAK20.52656883
114CDC70.51707869
115TIE10.51585932
116CAMK10.49456440
117PTK2B0.49249851
118GSK3A0.47748071
119BUB10.47435990
120MAP2K60.47230980
121BCKDK0.46672722
122PAK10.46633439
123CSNK1D0.45067258
124PLK10.44505492
125TSSK60.44312333
126CSNK1A10.44026432
127GRK50.42085982
128DYRK30.42068754
129CDK80.42023450
130DAPK30.41912350
131PRKAA10.41641834
132IRAK20.40844604
133STK30.40175907
134PTK20.39046178
135IKBKB0.37217081
136PRKAA20.36714804
137TEC0.36069288
138TNK20.35432916
139ITK0.35228168
140PRKACB0.35114485
141DYRK1A0.34600237
142ATR0.34185547
143RPS6KA40.33378603
144DAPK20.33290066
145NEK10.33080585
146BMX0.32685772
147NME10.31745671
148ATM0.31743287
149MOS0.30749104
150DDR20.30582367
151CDC42BPA0.30138370
152CSNK1E0.26320746
153HIPK20.26079575
154PLK20.25993568
155PRKACA0.25709018
156CSF1R0.24429691
157OBSCN0.23773756
158MAPK70.23282568
159SRC0.23270403
160AKT30.23006387
161INSR0.22926208

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.26879840
2Fatty acid elongation_Homo sapiens_hsa000624.80767364
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.16504936
4Steroid biosynthesis_Homo sapiens_hsa001003.65279117
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.91541197
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66479736
7Ether lipid metabolism_Homo sapiens_hsa005652.46467550
8Selenocompound metabolism_Homo sapiens_hsa004502.17305540
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09715000
10Fanconi anemia pathway_Homo sapiens_hsa034602.07350386
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04788773
12Axon guidance_Homo sapiens_hsa043602.03309424
13Butanoate metabolism_Homo sapiens_hsa006501.86954241
14Oxidative phosphorylation_Homo sapiens_hsa001901.86701422
15Basal transcription factors_Homo sapiens_hsa030221.86228526
16Homologous recombination_Homo sapiens_hsa034401.78697040
17Tryptophan metabolism_Homo sapiens_hsa003801.75509254
18Protein export_Homo sapiens_hsa030601.67796974
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63501025
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56457141
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53762828
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.52803671
23Nitrogen metabolism_Homo sapiens_hsa009101.46232880
24Histidine metabolism_Homo sapiens_hsa003401.44175560
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42780859
26RNA polymerase_Homo sapiens_hsa030201.40128880
27Sphingolipid metabolism_Homo sapiens_hsa006001.37517355
28Taste transduction_Homo sapiens_hsa047421.37213949
29Sulfur metabolism_Homo sapiens_hsa009201.36391397
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34538081
31GABAergic synapse_Homo sapiens_hsa047271.33160068
32Caffeine metabolism_Homo sapiens_hsa002321.32408626
33Linoleic acid metabolism_Homo sapiens_hsa005911.31365096
34Parkinsons disease_Homo sapiens_hsa050121.28804579
35Alzheimers disease_Homo sapiens_hsa050101.27852817
36Vitamin B6 metabolism_Homo sapiens_hsa007501.26977227
37Glutamatergic synapse_Homo sapiens_hsa047241.26789936
38Olfactory transduction_Homo sapiens_hsa047401.25273096
39RNA degradation_Homo sapiens_hsa030181.22384000
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21230342
41ABC transporters_Homo sapiens_hsa020101.20410946
42Vibrio cholerae infection_Homo sapiens_hsa051101.20267737
43Cardiac muscle contraction_Homo sapiens_hsa042601.18807851
44Morphine addiction_Homo sapiens_hsa050321.17475490
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14988964
46Fatty acid metabolism_Homo sapiens_hsa012121.14582079
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14040455
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13443001
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09441192
50Peroxisome_Homo sapiens_hsa041461.09035482
51One carbon pool by folate_Homo sapiens_hsa006701.08321874
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07691176
53Collecting duct acid secretion_Homo sapiens_hsa049661.06811953
54Renal cell carcinoma_Homo sapiens_hsa052111.06047782
55Serotonergic synapse_Homo sapiens_hsa047261.05121031
56Arginine and proline metabolism_Homo sapiens_hsa003301.03806873
57beta-Alanine metabolism_Homo sapiens_hsa004101.01643910
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96703507
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.93561019
60Long-term depression_Homo sapiens_hsa047300.91082180
61Salivary secretion_Homo sapiens_hsa049700.90714278
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90455071
63Cocaine addiction_Homo sapiens_hsa050300.90197109
64Circadian entrainment_Homo sapiens_hsa047130.89458139
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89235585
66Regulation of autophagy_Homo sapiens_hsa041400.87608833
67Non-homologous end-joining_Homo sapiens_hsa034500.86075050
68Tight junction_Homo sapiens_hsa045300.84321735
69Fatty acid degradation_Homo sapiens_hsa000710.84010503
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83866641
71Chemical carcinogenesis_Homo sapiens_hsa052040.83631396
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.82891854
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.80417300
74ErbB signaling pathway_Homo sapiens_hsa040120.78020294
75Propanoate metabolism_Homo sapiens_hsa006400.77096496
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75009972
77Synaptic vesicle cycle_Homo sapiens_hsa047210.74459520
78Dorso-ventral axis formation_Homo sapiens_hsa043200.73726175
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73479661
80Glycerolipid metabolism_Homo sapiens_hsa005610.72979681
81Retinol metabolism_Homo sapiens_hsa008300.72779943
82Dilated cardiomyopathy_Homo sapiens_hsa054140.71780357
83Renin secretion_Homo sapiens_hsa049240.71580329
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70560315
85Rheumatoid arthritis_Homo sapiens_hsa053230.70424705
86Gastric acid secretion_Homo sapiens_hsa049710.70194694
87ECM-receptor interaction_Homo sapiens_hsa045120.69288286
88Fat digestion and absorption_Homo sapiens_hsa049750.68001021
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.67750555
90Purine metabolism_Homo sapiens_hsa002300.67628960
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67059009
92Metabolic pathways_Homo sapiens_hsa011000.65743528
93Nicotine addiction_Homo sapiens_hsa050330.65491846
94Sulfur relay system_Homo sapiens_hsa041220.65136992
95Autoimmune thyroid disease_Homo sapiens_hsa053200.63687841
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62446365
97Mineral absorption_Homo sapiens_hsa049780.62340050
98Hedgehog signaling pathway_Homo sapiens_hsa043400.61850633
99Ras signaling pathway_Homo sapiens_hsa040140.61214375
100Phagosome_Homo sapiens_hsa041450.60760314
101Phototransduction_Homo sapiens_hsa047440.60390926
102Ovarian steroidogenesis_Homo sapiens_hsa049130.60234564
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60141509
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58848302
105Calcium signaling pathway_Homo sapiens_hsa040200.58024717
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57486526
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57482102
108Cholinergic synapse_Homo sapiens_hsa047250.57281155
109Nucleotide excision repair_Homo sapiens_hsa034200.57133907
110Dopaminergic synapse_Homo sapiens_hsa047280.56922415
111TGF-beta signaling pathway_Homo sapiens_hsa043500.55481380
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55163445
113Glutathione metabolism_Homo sapiens_hsa004800.54645835
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51371356
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.50619337
116Endocytosis_Homo sapiens_hsa041440.50301904
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49534132
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49524640
119Lysosome_Homo sapiens_hsa041420.49494621
120Circadian rhythm_Homo sapiens_hsa047100.48403839
121Arachidonic acid metabolism_Homo sapiens_hsa005900.47735830
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.47514995
123Huntingtons disease_Homo sapiens_hsa050160.45465475
124Pyrimidine metabolism_Homo sapiens_hsa002400.44850420
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43615464
126Gap junction_Homo sapiens_hsa045400.43259038
127Folate biosynthesis_Homo sapiens_hsa007900.43042232
128Pancreatic secretion_Homo sapiens_hsa049720.42425234
129Malaria_Homo sapiens_hsa051440.41180613
130Prion diseases_Homo sapiens_hsa050200.41059382
131Fatty acid biosynthesis_Homo sapiens_hsa000610.40147426
132Vitamin digestion and absorption_Homo sapiens_hsa049770.40038146
133cAMP signaling pathway_Homo sapiens_hsa040240.38921261
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38001817
135Basal cell carcinoma_Homo sapiens_hsa052170.37612746
136Tyrosine metabolism_Homo sapiens_hsa003500.37455827
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35580092
138Lysine degradation_Homo sapiens_hsa003100.34456032
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33688758
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.33586833
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.33553421
142Insulin secretion_Homo sapiens_hsa049110.33431681
143Pyruvate metabolism_Homo sapiens_hsa006200.33234875
144Amphetamine addiction_Homo sapiens_hsa050310.32738516
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32655584
146Wnt signaling pathway_Homo sapiens_hsa043100.32431382
147Melanogenesis_Homo sapiens_hsa049160.31784859
148PPAR signaling pathway_Homo sapiens_hsa033200.31119164

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