TLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.07144485
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.99083342
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.99083342
4antigen processing and presentation of endogenous antigen (GO:0019883)4.54380305
5regulation of gamma-delta T cell differentiation (GO:0045586)4.17546213
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97199598
7regulation of gamma-delta T cell activation (GO:0046643)3.85555750
8positive thymic T cell selection (GO:0045059)3.78245385
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56307676
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.56307676
11modulation by symbiont of host immune response (GO:0052553)3.56307676
12positive regulation by symbiont of host defense response (GO:0052509)3.56307676
13modulation by symbiont of host defense response (GO:0052031)3.56307676
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56307676
15regulation of B cell receptor signaling pathway (GO:0050855)3.53622475
16positive regulation of B cell differentiation (GO:0045579)3.53482242
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48549208
18negative regulation of cell killing (GO:0031342)3.48549208
19detection of molecule of bacterial origin (GO:0032490)3.45228030
20negative regulation of phagocytosis (GO:0050765)3.41513024
21regulation of interferon-beta biosynthetic process (GO:0045357)3.40547847
22cellular extravasation (GO:0045123)3.37376197
23positive regulation of histone deacetylation (GO:0031065)3.34958542
24detection of other organism (GO:0098543)3.32807979
25pinocytosis (GO:0006907)3.27531115
26leukocyte aggregation (GO:0070486)3.24431665
27apoptotic cell clearance (GO:0043277)3.23876645
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22022352
29positive regulation of receptor recycling (GO:0001921)3.18826881
30negative regulation of granulocyte differentiation (GO:0030853)3.15254591
31detection of external biotic stimulus (GO:0098581)3.13687954
32mannose metabolic process (GO:0006013)3.11264515
33regulation of B cell differentiation (GO:0045577)3.08940480
34response to laminar fluid shear stress (GO:0034616)3.07063753
35detection of bacterium (GO:0016045)3.06107221
36stress fiber assembly (GO:0043149)3.01147786
37hypotonic response (GO:0006971)2.99739232
38B cell receptor signaling pathway (GO:0050853)2.99017779
39antigen processing and presentation via MHC class Ib (GO:0002475)2.98055509
40response to muramyl dipeptide (GO:0032495)2.95694790
41negative thymic T cell selection (GO:0045060)2.93110990
42regulation of interleukin-12 biosynthetic process (GO:0045075)2.92849322
43negative regulation of interleukin-12 production (GO:0032695)2.92654460
44leukocyte cell-cell adhesion (GO:0007159)2.89914012
45barbed-end actin filament capping (GO:0051016)2.89794014
46Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89181573
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.87387745
48regulation of macrophage cytokine production (GO:0010935)2.86267906
49negative regulation of erythrocyte differentiation (GO:0045647)2.84565809
50regulation of integrin activation (GO:0033623)2.84082025
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83894659
52negative T cell selection (GO:0043383)2.83156014
53thymic T cell selection (GO:0045061)2.82941410
54tolerance induction (GO:0002507)2.81971309
55positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.79732507
56regulation of leukocyte degranulation (GO:0043300)2.79568730
57regulation of mast cell degranulation (GO:0043304)2.75098100
58detection of biotic stimulus (GO:0009595)2.73322019
59neutrophil activation involved in immune response (GO:0002283)2.72089390
60positive regulation of interferon-alpha production (GO:0032727)2.69948678
61cell adhesion mediated by integrin (GO:0033627)2.69736216
62megakaryocyte development (GO:0035855)2.68360911
63macrophage activation involved in immune response (GO:0002281)2.67872182
64regulation of platelet aggregation (GO:0090330)2.67749505
65natural killer cell differentiation (GO:0001779)2.64851913
66regulation of myeloid leukocyte mediated immunity (GO:0002886)2.64300574
67germ cell migration (GO:0008354)2.64005951
68positive T cell selection (GO:0043368)2.63403226
69positive regulation of natural killer cell differentiation (GO:0032825)2.63244144
70positive regulation of cellular amide metabolic process (GO:0034250)2.61737329
71angiogenesis involved in wound healing (GO:0060055)2.58356990
72immunoglobulin mediated immune response (GO:0016064)2.58032899
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57327697
74lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56583250
75regulation of interferon-alpha production (GO:0032647)2.56284184
76positive regulation of protein deacetylation (GO:0090312)2.56155319
77integrin-mediated signaling pathway (GO:0007229)2.55292620
78negative regulation of stress fiber assembly (GO:0051497)2.54774666
79definitive hemopoiesis (GO:0060216)2.49092277
80regulation of mast cell activation involved in immune response (GO:0033006)2.48248797
81macrophage activation (GO:0042116)2.46755639
82T cell migration (GO:0072678)2.45839941
83regulation of T-helper 2 cell differentiation (GO:0045628)2.45339432
84response to fluid shear stress (GO:0034405)2.45260496
85negative regulation of lymphocyte mediated immunity (GO:0002707)2.44275833
86regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43735156
87endodermal cell differentiation (GO:0035987)2.43374037
88T cell selection (GO:0045058)2.43294094
89hepatocyte apoptotic process (GO:0097284)2.41577910
90negative regulation of T cell mediated immunity (GO:0002710)2.40875632
91response to interleukin-15 (GO:0070672)2.40014805
92positive regulation of macrophage cytokine production (GO:0060907)2.39637962
93negative regulation of leukocyte mediated immunity (GO:0002704)2.39632168
94regulation of necroptotic process (GO:0060544)2.39610946
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38351074
96embryonic process involved in female pregnancy (GO:0060136)2.37721621
97germinal center formation (GO:0002467)2.37602923
98positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37136729
99substrate-dependent cell migration (GO:0006929)2.36239952
100regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.34981494
101positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.34540998
102respiratory burst (GO:0045730)2.33972381
103positive regulation of cell adhesion mediated by integrin (GO:0033630)2.33932772
104heterotypic cell-cell adhesion (GO:0034113)2.33901377
105regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33854259
106regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32863892
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.32781109
108growth hormone receptor signaling pathway (GO:0060396)2.31836791
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.31675542
110response to host (GO:0075136)2.31675542
111response to host defenses (GO:0052200)2.31675542
112positive regulation of Cdc42 GTPase activity (GO:0043089)2.31468554
113vascular endothelial growth factor signaling pathway (GO:0038084)2.30848912
114hyaluronan catabolic process (GO:0030214)2.30833572
115microglial cell activation (GO:0001774)2.30773036
116granulocyte activation (GO:0036230)2.30111703
117response to peptidoglycan (GO:0032494)2.29497561
118membrane raft organization (GO:0031579)2.29142814
119negative regulation of fatty acid transport (GO:2000192)2.29012773
120regulation of extracellular matrix disassembly (GO:0010715)2.28916097
121positive regulation of macrophage differentiation (GO:0045651)2.28794234
122regulation of early endosome to late endosome transport (GO:2000641)2.28179081
123* platelet aggregation (GO:0070527)2.28124600
124leukocyte migration involved in inflammatory response (GO:0002523)2.28095542
125myeloid cell activation involved in immune response (GO:0002275)2.27654954
126protein localization to endosome (GO:0036010)2.26502451
127regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.26461433
128positive regulation of lamellipodium assembly (GO:0010592)2.26379431
129skin morphogenesis (GO:0043589)2.25470928
130positive regulation of antigen processing and presentation (GO:0002579)2.25408561
131positive regulation of tumor necrosis factor production (GO:0032760)2.25204595
132positive regulation of mast cell activation (GO:0033005)2.25134821
133myeloid dendritic cell activation (GO:0001773)2.24927984
134regulation of phagocytosis (GO:0050764)2.24568922
135negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.24540321
136regulation of response to interferon-gamma (GO:0060330)2.24099564
137neutrophil activation (GO:0042119)2.23928265
138regulation of erythrocyte differentiation (GO:0045646)2.23461507
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.23134881
140regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.22492127
141regulation of cholesterol storage (GO:0010885)2.21875694
142regulation of T cell tolerance induction (GO:0002664)2.20788919
143response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.20535605
144response to host immune response (GO:0052572)2.20535605
145morphogenesis of an endothelium (GO:0003159)2.20351022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.92524848
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.79452041
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.39879499
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37330129
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.37251352
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.30757259
7MYC_22102868_ChIP-Seq_BL_Human3.07446104
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90874633
9VDR_21846776_ChIP-Seq_THP-1_Human2.85537866
10* IRF8_21731497_ChIP-ChIP_J774_Mouse2.70444872
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65342190
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.63832292
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50988069
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44498814
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.43017133
16SCL_19346495_ChIP-Seq_HPC-7_Human2.42455638
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.36260464
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.24957341
19TCF7_22412390_ChIP-Seq_EML_Mouse2.21901536
20MAF_26560356_Chip-Seq_TH1_Human2.19181474
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.12473428
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12460523
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.05556093
24VDR_24763502_ChIP-Seq_THP-1_Human2.05248972
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01893316
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01444335
27UTX_26944678_Chip-Seq_JUKART_Human1.99425513
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98432368
29MYB_26560356_Chip-Seq_TH2_Human1.96276425
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95855637
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92554748
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90134749
33RUNX_20019798_ChIP-Seq_JUKART_Human1.89200045
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88464360
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85589105
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.82542645
37SPI1_23127762_ChIP-Seq_K562_Human1.81751816
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81620332
39KDM2B_26808549_Chip-Seq_DND41_Human1.81414606
40MYB_26560356_Chip-Seq_TH1_Human1.80116173
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79760129
42* SPI1_23547873_ChIP-Seq_NB4_Human1.75707918
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74186298
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67931628
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67726798
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63449109
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62109953
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58299131
49CLOCK_20551151_ChIP-Seq_293T_Human1.53512334
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.49396580
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49177852
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48332864
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47030249
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45852334
55* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45818051
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41874647
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39653945
58GATA1_22025678_ChIP-Seq_K562_Human1.34918233
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31329774
60MAF_26560356_Chip-Seq_TH2_Human1.30623212
61KDM2B_26808549_Chip-Seq_K562_Human1.27820853
62PU_27001747_Chip-Seq_BMDM_Mouse1.26527485
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26378631
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26234534
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25240667
66NCOR1_26117541_ChIP-Seq_K562_Human1.24820745
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24576732
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21618184
69LXR_22292898_ChIP-Seq_THP-1_Human1.20852463
70* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20405282
71GATA1_19941826_ChIP-Seq_K562_Human1.18084327
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.17220429
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.17039384
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16651352
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16649866
76GATA3_27048872_Chip-Seq_THYMUS_Human1.15068234
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14410035
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14365862
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13871704
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13273536
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12218515
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09724929
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.08700852
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07974334
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.07836388
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.07836388
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07221578
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06474345
89RACK7_27058665_Chip-Seq_MCF-7_Human1.06311529
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.06139091
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04592241
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04161580
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03761298
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03650046
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02914218
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02601483
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01375498
98TFEB_21752829_ChIP-Seq_HELA_Human1.00877355
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00861535
100CIITA_25753668_ChIP-Seq_RAJI_Human1.00197437
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98836084
102HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97736015
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97177862
104* GATA2_19941826_ChIP-Seq_K562_Human0.97157332
105ATF3_27146783_Chip-Seq_COLON_Human0.96707368
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.95399786
107SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95159680
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94632692
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94564696
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90352710
111* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90049237
112* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90049237
113VDR_24787735_ChIP-Seq_THP-1_Human0.88381713
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86648117
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84039103
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82015538
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80981225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen2.87664713
2MP0003300_gastrointestinal_ulcer2.77032516
3MP0003303_peritoneal_inflammation2.74671179
4MP0003705_abnormal_hypodermis_morpholog2.59271793
5MP0001835_abnormal_antigen_presentation2.51178470
6MP0003566_abnormal_cell_adhesion2.42410593
7MP0003436_decreased_susceptibility_to2.41341373
8MP0000685_abnormal_immune_system2.36580123
9MP0009278_abnormal_bone_marrow2.31266826
10MP0002396_abnormal_hematopoietic_system2.31246917
11MP0010352_gastrointestinal_tract_polyps2.15168344
12MP0005451_abnormal_body_composition2.11964158
13MP0005464_abnormal_platelet_physiology2.06258047
14MP0004808_abnormal_hematopoietic_stem2.05729989
15MP0001790_abnormal_immune_system2.03127428
16MP0005387_immune_system_phenotype2.03127428
17MP0008260_abnormal_autophagy2.01454941
18MP0001800_abnormal_humoral_immune1.97155457
19MP0002166_altered_tumor_susceptibility1.96893842
20MP0005058_abnormal_lysosome_morphology1.92970156
21MP0002419_abnormal_innate_immunity1.91828264
22MP0002452_abnormal_antigen_presenting1.88596902
23MP0003279_aneurysm1.85076924
24MP0005000_abnormal_immune_tolerance1.81789720
25MP0002420_abnormal_adaptive_immunity1.71474382
26MP0005023_abnormal_wound_healing1.69947221
27MP0001819_abnormal_immune_cell1.69745665
28MP0005025_abnormal_response_to1.69028291
29MP0005671_abnormal_response_to1.68923726
30MP0005397_hematopoietic_system_phenotyp1.67470076
31MP0001545_abnormal_hematopoietic_system1.67470076
32MP0002723_abnormal_immune_serum1.65262340
33MP0002398_abnormal_bone_marrow1.63334883
34MP0001958_emphysema1.63151163
35MP0002405_respiratory_system_inflammati1.61177539
36MP0000465_gastrointestinal_hemorrhage1.61033828
37MP0005076_abnormal_cell_differentiation1.58685006
38MP0004947_skin_inflammation1.57892401
39MP0003763_abnormal_thymus_physiology1.52776018
40MP0003091_abnormal_cell_migration1.52473290
41MP0000569_abnormal_digit_pigmentation1.51856222
42MP0001533_abnormal_skeleton_physiology1.51072568
43MP0006054_spinal_hemorrhage1.49130687
44MP0009785_altered_susceptibility_to1.48583217
45MP0010307_abnormal_tumor_latency1.45972846
46MP0000689_abnormal_spleen_morphology1.44570946
47MP0000716_abnormal_immune_system1.44452153
48MP0006082_CNS_inflammation1.43648217
49MP0003172_abnormal_lysosome_physiology1.42755579
50MP0002877_abnormal_melanocyte_morpholog1.41899396
51MP0002722_abnormal_immune_system1.40760433
52MP0010155_abnormal_intestine_physiology1.40691220
53MP0009333_abnormal_splenocyte_physiolog1.39618939
54MP0002006_tumorigenesis1.38885029
55MP0002933_joint_inflammation1.37654873
56MP0004510_myositis1.36030420
57MP0004883_abnormal_blood_vessel1.33713550
58MP0001873_stomach_inflammation1.33346605
59MP0003724_increased_susceptibility_to1.32175027
60MP0003448_altered_tumor_morphology1.30199898
61MP0002429_abnormal_blood_cell1.29331902
62MP0003191_abnormal_cellular_cholesterol1.29033679
63MP0008004_abnormal_stomach_pH1.28309030
64MP0005164_abnormal_response_to1.28199342
65MP0003656_abnormal_erythrocyte_physiolo1.27811612
66MP0005275_abnormal_skin_tensile1.27309627
67MP0000858_altered_metastatic_potential1.26543887
68MP0001845_abnormal_inflammatory_respons1.26376993
69MP0002148_abnormal_hypersensitivity_rea1.25242533
70MP0001853_heart_inflammation1.17748751
71MP0000703_abnormal_thymus_morphology1.17712003
72MP0000767_abnormal_smooth_muscle1.17624544
73MP0000733_abnormal_muscle_development1.17224906
74MP0003828_pulmonary_edema1.17168601
75MP0000343_altered_response_to1.16998649
76MP0009840_abnormal_foam_cell1.16258600
77MP0005409_darkened_coat_color1.15738999
78MP0000490_abnormal_crypts_of1.07694655
79MP0002998_abnormal_bone_remodeling1.03014133
80MP0001915_intracranial_hemorrhage1.02525783
81MP0003045_fibrosis1.00522560
82MP0003075_altered_response_to0.97752851
83MP0005174_abnormal_tail_pigmentation0.95933952
84MP0008469_abnormal_protein_level0.94132600
85MP0000604_amyloidosis0.92865866
86MP0005503_abnormal_tendon_morphology0.91846531
87MP0001542_abnormal_bone_strength0.89022989
88MP0002060_abnormal_skin_morphology0.88337162
89MP0005390_skeleton_phenotype0.87692661
90MP0010368_abnormal_lymphatic_system0.87173925
91MP0001851_eye_inflammation0.86895149
92MP0001243_abnormal_dermal_layer0.86558087
93MP0005623_abnormal_meninges_morphology0.85486648
94MP0000249_abnormal_blood_vessel0.84180063
95MP0010630_abnormal_cardiac_muscle0.82165583
96MP0004272_abnormal_basement_membrane0.81576279
97MP0004130_abnormal_muscle_cell0.81412293
98MP0003866_abnormal_defecation0.81396188
99MP0001879_abnormal_lymphatic_vessel0.79685380
100MP0004185_abnormal_adipocyte_glucose0.79126341
101MP0003183_abnormal_peptide_metabolism0.78869844
102MP0000371_diluted_coat_color0.78006035
103MP0003690_abnormal_glial_cell0.77869930
104MP0002128_abnormal_blood_circulation0.77494407
105MP0002019_abnormal_tumor_incidence0.77063693
106MP0004858_abnormal_nervous_system0.76931457
107MP0003950_abnormal_plasma_membrane0.76611275
108MP0005670_abnormal_white_adipose0.76255247
109MP0003795_abnormal_bone_structure0.75390432
110MP0005257_abnormal_intraocular_pressure0.74942190
111MP0005595_abnormal_vascular_smooth0.73173438
112MP0009763_increased_sensitivity_to0.71949756
113MP0002925_abnormal_cardiovascular_devel0.70560064
114MP0001614_abnormal_blood_vessel0.69651879
115MP0003453_abnormal_keratinocyte_physiol0.67113551
116MP0005621_abnormal_cell_physiology0.65510504
117MP0001849_ear_inflammation0.65100764

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.82938853
2Recurrent abscess formation (HP:0002722)3.52235627
3Eczematoid dermatitis (HP:0000976)3.50935539
4Protrusio acetabuli (HP:0003179)3.23008840
5Aortic aneurysm (HP:0004942)3.13594643
6Increased density of long bones (HP:0006392)3.04708147
7Recurrent bacterial skin infections (HP:0005406)3.02047014
8Cellulitis (HP:0100658)2.89930969
9Premature rupture of membranes (HP:0001788)2.86997788
10Osteolytic defects of the phalanges of the hand (HP:0009771)2.85786798
11Osteolytic defects of the hand bones (HP:0009699)2.85786798
12Abnormal platelet volume (HP:0011876)2.84191156
13Aortic dissection (HP:0002647)2.80753485
14Spontaneous hematomas (HP:0007420)2.78810720
15Recurrent viral infections (HP:0004429)2.77836002
16Recurrent fungal infections (HP:0002841)2.71754961
17Hematochezia (HP:0002573)2.71294733
18Cervical subluxation (HP:0003308)2.68630951
19Peritonitis (HP:0002586)2.67722669
20Increased mean platelet volume (HP:0011877)2.61226541
21Systemic lupus erythematosus (HP:0002725)2.57534530
22Prolonged bleeding time (HP:0003010)2.55473770
23Ankle contracture (HP:0006466)2.53214318
24Increased variability in muscle fiber diameter (HP:0003557)2.51938712
25Increased cerebral lipofuscin (HP:0011813)2.49394428
26Chronic otitis media (HP:0000389)2.47143713
27Vascular tortuosity (HP:0004948)2.45505672
28Mitral valve prolapse (HP:0001634)2.43894823
29Shallow orbits (HP:0000586)2.42695193
30Myositis (HP:0100614)2.41825846
31Dilatation of the ascending aorta (HP:0005111)2.40838374
32Arterial tortuosity (HP:0005116)2.40501606
33Abnormality of the nasal mucosa (HP:0000433)2.38667069
34Pustule (HP:0200039)2.38081359
35Abnormality of skeletal muscle fiber size (HP:0012084)2.36105000
36Recurrent gram-negative bacterial infections (HP:0005420)2.35444191
37Polycythemia (HP:0001901)2.35117360
38IgM deficiency (HP:0002850)2.33287248
39Spondylolisthesis (HP:0003302)2.32172226
40Nasal polyposis (HP:0100582)2.30143458
41Abnormality of the fingertips (HP:0001211)2.28567541
42Autoimmune thrombocytopenia (HP:0001973)2.28332307
43Interstitial pulmonary disease (HP:0006530)2.26926500
44Persistence of primary teeth (HP:0006335)2.26417642
45Inflammation of the large intestine (HP:0002037)2.25499371
46Distal lower limb amyotrophy (HP:0008944)2.25447492
47Gastrointestinal inflammation (HP:0004386)2.25157531
48Ulnar bowing (HP:0003031)2.23766289
49Periodontitis (HP:0000704)2.23397044
50Petechiae (HP:0000967)2.23279909
51Abnormal platelet function (HP:0011869)2.21652372
52Impaired platelet aggregation (HP:0003540)2.21652372
53Increased connective tissue (HP:0009025)2.21530860
54Wormian bones (HP:0002645)2.20430131
55Myocardial infarction (HP:0001658)2.19928448
56Gastrointestinal infarctions (HP:0005244)2.19917566
57Colitis (HP:0002583)2.19394735
58Elevated erythrocyte sedimentation rate (HP:0003565)2.17866262
59Dysostosis multiplex (HP:0000943)2.17199619
60Vacuolated lymphocytes (HP:0001922)2.17011229
61Purpura (HP:0000979)2.13671107
62Epistaxis (HP:0000421)2.13662127
63Absent frontal sinuses (HP:0002688)2.13168715
64Thrombocytosis (HP:0001894)2.13152734
65Abnormality of macrophages (HP:0004311)2.13107199
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.12700047
67Aneurysm (HP:0002617)2.07896298
68Syringomyelia (HP:0003396)2.07628943
69Spinal cord lesions (HP:0100561)2.07628943
70Recurrent skin infections (HP:0001581)2.05144842
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.02285260
72Arterial thrombosis (HP:0004420)2.00302340
73Blue sclerae (HP:0000592)1.99815589
74Fragile skin (HP:0001030)1.99659627
75Bicuspid aortic valve (HP:0001647)1.96534736
76Abnormality of glycolipid metabolism (HP:0010969)1.96421611
77Abnormality of liposaccharide metabolism (HP:0010968)1.96421611
78Abnormality of glycosphingolipid metabolism (HP:0004343)1.96421611
79Gingivitis (HP:0000230)1.96099972
80Abnormality of the peritoneum (HP:0002585)1.95056604
81Radial bowing (HP:0002986)1.94826346
82Hyperacusis (HP:0010780)1.94726155
83Mucopolysacchariduria (HP:0008155)1.94331571
84Urinary glycosaminoglycan excretion (HP:0003541)1.94331571
85Spinal rigidity (HP:0003306)1.94215786
86Recurrent bronchitis (HP:0002837)1.94009817
87Menorrhagia (HP:0000132)1.93916127
88Retrobulbar optic neuritis (HP:0100654)1.93514905
89Optic neuritis (HP:0100653)1.93514905
90Verrucae (HP:0200043)1.92883038
91Papilloma (HP:0012740)1.92883038
92Increased IgE level (HP:0003212)1.92177818
93Genu recurvatum (HP:0002816)1.92139077
94Emphysema (HP:0002097)1.91809328
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91185222
96Osteomyelitis (HP:0002754)1.89848807
97Chronic obstructive pulmonary disease (HP:0006510)1.89102291
98Disproportionate tall stature (HP:0001519)1.88357632
99Atrophic scars (HP:0001075)1.88258279
100T lymphocytopenia (HP:0005403)1.86842301
101Meningitis (HP:0001287)1.86769180
102Bruising susceptibility (HP:0000978)1.86348139
103Mediastinal lymphadenopathy (HP:0100721)1.86143638
104Mitral stenosis (HP:0001718)1.85877017
105Broad metatarsal (HP:0001783)1.85796698
106Leukocytosis (HP:0001974)1.85032675
107Amyloidosis (HP:0011034)1.84681045
108Thin bony cortex (HP:0002753)1.84284226
109Mitral regurgitation (HP:0001653)1.84043240
110Distal upper limb amyotrophy (HP:0007149)1.83820378
111Upper limb amyotrophy (HP:0009129)1.83820378
112Gingival bleeding (HP:0000225)1.83090034
113Thoracic kyphosis (HP:0002942)1.81729993
114Broad face (HP:0000283)1.80711970
115Wrist flexion contracture (HP:0001239)1.80490937
116Distal lower limb muscle weakness (HP:0009053)1.80462348
117Abnormality of the thoracic spine (HP:0100711)1.80276506
118Orchitis (HP:0100796)1.78456553
119Abnormality of polysaccharide metabolism (HP:0011012)1.78186121
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78186121
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78186121
122Vertebral compression fractures (HP:0002953)1.77420846
123Frequent falls (HP:0002359)1.77009698
124Chronic mucocutaneous candidiasis (HP:0002728)1.76494178
125Recurrent cutaneous fungal infections (HP:0011370)1.76494178
126Chest pain (HP:0100749)1.76324532
127Obstructive lung disease (HP:0006536)1.76066756
128Slender build (HP:0001533)1.75700399
129Bladder diverticulum (HP:0000015)1.73531484
130Joint laxity (HP:0001388)1.72648316
131Type 1 muscle fiber predominance (HP:0003803)1.71473329
132Abnormality of T cell number (HP:0011839)1.69569420
133Dislocated radial head (HP:0003083)1.68122118
134Subacute progressive viral hepatitis (HP:0006572)1.67927954
135Vasculitis (HP:0002633)1.67204957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.70057301
2MAP4K13.50959233
3TTN3.35955430
4PRPF4B3.24585341
5EEF2K3.11057127
6PKN23.03199689
7ERN12.46748020
8STK102.35277785
9MAP3K102.27447668
10TYK22.08155668
11KIT1.96155998
12TGFBR21.93245509
13MAP2K31.93017112
14JAK31.89309262
15EPHB11.87384249
16CDK121.84662534
17LRRK21.80481184
18ZAP701.76268060
19PTK61.75578972
20SMG11.72148062
21CAMK1D1.70108933
22JAK11.55490882
23BTK1.49463686
24ICK1.49372370
25TRPM71.48933366
26RIPK11.48308736
27CSF1R1.48201797
28TBK11.48017980
29FGFR41.42493146
30TAOK31.35000585
31CDC42BPA1.34721529
32BLK1.29435760
33CSK1.28259992
34HCK1.27485117
35CAMK1G1.25525817
36PIK3CG1.24561175
37MYLK1.22689371
38ITK1.21347735
39GRK61.20682781
40KSR21.18163724
41TAOK21.16385735
42PAK41.16361110
43SIK11.14840942
44TXK1.13962799
45FGFR31.13569537
46MAP3K61.12875096
47FGR1.10764459
48PRKD21.09972018
49MARK21.07910806
50RPS6KA41.07240756
51MAP3K11.06830711
52MAP3K141.03955069
53IRAK41.03580578
54FLT31.03257441
55TAOK11.00927792
56BMX1.00428104
57LCK0.99102039
58PDGFRA0.97113073
59SCYL20.94328828
60IKBKE0.92147930
61SYK0.91788698
62PIM10.90459499
63CLK10.89186998
64CDK60.88310596
65SIK20.88301185
66KDR0.88234748
67MAP3K110.86883225
68DDR20.86881745
69PDPK10.86416354
70DMPK0.86107301
71MARK30.85999340
72IKBKB0.83562539
73TEC0.83557629
74PTK2B0.83352296
75PAK20.81823863
76CDK40.79994760
77FES0.79538561
78NEK90.78732662
79JAK20.78564881
80NEK20.78228798
81RPS6KB20.77713619
82MOS0.77544381
83MTOR0.76919566
84MAPK70.75579274
85STK40.75397987
86TGFBR10.73976779
87CHUK0.73951564
88STK380.73732742
89MAP3K80.72675784
90PDGFRB0.71526307
91MAPK120.71334071
92SGK30.70268392
93PDK10.70238941
94EPHA30.66427324
95PRKCH0.64919973
96HIPK20.64553204
97MAP3K70.63640521
98STK30.61474864
99MAP3K30.60668517
100IRAK30.59980769
101ALK0.59160262
102LYN0.58733555
103BMPR20.58726496
104WNK10.57100083
105RPS6KA60.56957416
106MAP3K20.55065550
107MELK0.53504040
108RPS6KC10.53195868
109RPS6KL10.53195868
110PTK20.52344865
111MATK0.52055651
112MAPK110.51454589
113CDK90.51095884
114ILK0.49689927
115RPS6KA20.49629910
116MAPKAPK30.49504023
117NME20.48727897
118MAPKAPK20.47478283
119YES10.46669785
120EGFR0.46649148
121IRAK10.45966723
122BRD40.45399793
123RET0.41786825
124ABL10.36986740
125MAP3K130.36542071
126RIPK40.36149017
127PRKG20.35004178
128PIM20.34777746
129TNK20.34223050
130TESK20.33573436
131TIE10.32554741
132PRKD10.32504849

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.51253867
2Staphylococcus aureus infection_Homo sapiens_hsa051502.18111806
3B cell receptor signaling pathway_Homo sapiens_hsa046622.17252170
4Osteoclast differentiation_Homo sapiens_hsa043802.17069124
5Chronic myeloid leukemia_Homo sapiens_hsa052201.87309822
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.84223431
7Primary immunodeficiency_Homo sapiens_hsa053401.83923297
8Leukocyte transendothelial migration_Homo sapiens_hsa046701.79440385
9Antigen processing and presentation_Homo sapiens_hsa046121.77238416
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.77027621
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76663649
12Toxoplasmosis_Homo sapiens_hsa051451.75333908
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75178722
14Measles_Homo sapiens_hsa051621.72196306
15Other glycan degradation_Homo sapiens_hsa005111.63365883
16Hematopoietic cell lineage_Homo sapiens_hsa046401.61383748
17Viral myocarditis_Homo sapiens_hsa054161.61300713
18Malaria_Homo sapiens_hsa051441.58035875
19Small cell lung cancer_Homo sapiens_hsa052221.56512159
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56390741
21Shigellosis_Homo sapiens_hsa051311.53891449
22Caffeine metabolism_Homo sapiens_hsa002321.51722565
23Acute myeloid leukemia_Homo sapiens_hsa052211.50326221
24Pertussis_Homo sapiens_hsa051331.46246982
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45987728
26* Platelet activation_Homo sapiens_hsa046111.45626295
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45265556
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45222625
29Apoptosis_Homo sapiens_hsa042101.39921353
30* Focal adhesion_Homo sapiens_hsa045101.39414252
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38513642
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37277558
33Pancreatic cancer_Homo sapiens_hsa052121.35989659
34ECM-receptor interaction_Homo sapiens_hsa045121.31567193
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.30872905
36Tuberculosis_Homo sapiens_hsa051521.30236830
37T cell receptor signaling pathway_Homo sapiens_hsa046601.29345507
38Lysosome_Homo sapiens_hsa041421.29013291
39Hepatitis B_Homo sapiens_hsa051611.28139983
40Amoebiasis_Homo sapiens_hsa051461.25912745
41Proteoglycans in cancer_Homo sapiens_hsa052051.25750724
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23909964
43Legionellosis_Homo sapiens_hsa051341.23374462
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.22388429
45TNF signaling pathway_Homo sapiens_hsa046681.16329870
46Chemokine signaling pathway_Homo sapiens_hsa040621.13260759
47Influenza A_Homo sapiens_hsa051641.12950945
48Herpes simplex infection_Homo sapiens_hsa051681.12381308
49Salmonella infection_Homo sapiens_hsa051321.11021543
50Viral carcinogenesis_Homo sapiens_hsa052031.07055771
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04278471
52Lysine degradation_Homo sapiens_hsa003101.02587930
53MicroRNAs in cancer_Homo sapiens_hsa052061.02009695
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01342644
55Non-small cell lung cancer_Homo sapiens_hsa052230.99225366
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.99084654
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.98391575
58Adherens junction_Homo sapiens_hsa045200.98045243
59Notch signaling pathway_Homo sapiens_hsa043300.95528938
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93958241
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93838538
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93177082
63* HTLV-I infection_Homo sapiens_hsa051660.92630974
64Allograft rejection_Homo sapiens_hsa053300.91523548
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90178530
66Insulin resistance_Homo sapiens_hsa049310.89967781
67VEGF signaling pathway_Homo sapiens_hsa043700.88993794
68GnRH signaling pathway_Homo sapiens_hsa049120.84724529
69Autoimmune thyroid disease_Homo sapiens_hsa053200.83199786
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81165708
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80952030
72HIF-1 signaling pathway_Homo sapiens_hsa040660.80200121
73Thyroid cancer_Homo sapiens_hsa052160.78844989
74Hepatitis C_Homo sapiens_hsa051600.77876670
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.76852092
76Colorectal cancer_Homo sapiens_hsa052100.76190085
77Prolactin signaling pathway_Homo sapiens_hsa049170.75488733
78Complement and coagulation cascades_Homo sapiens_hsa046100.75216724
79mTOR signaling pathway_Homo sapiens_hsa041500.74325146
80Inositol phosphate metabolism_Homo sapiens_hsa005620.73717264
81Choline metabolism in cancer_Homo sapiens_hsa052310.73594996
82Prion diseases_Homo sapiens_hsa050200.73399829
83African trypanosomiasis_Homo sapiens_hsa051430.71980403
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.71664929
85Phagosome_Homo sapiens_hsa041450.70318655
86ErbB signaling pathway_Homo sapiens_hsa040120.69825395
87Epstein-Barr virus infection_Homo sapiens_hsa051690.68219060
88Dorso-ventral axis formation_Homo sapiens_hsa043200.67550680
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.65830536
90Estrogen signaling pathway_Homo sapiens_hsa049150.64833257
91p53 signaling pathway_Homo sapiens_hsa041150.64796525
92Prostate cancer_Homo sapiens_hsa052150.64415792
93Endocytosis_Homo sapiens_hsa041440.64380086
94Renal cell carcinoma_Homo sapiens_hsa052110.63075736
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62565026
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61265437
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60692030
98Pathways in cancer_Homo sapiens_hsa052000.60496411
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57908750
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56445247
101Bladder cancer_Homo sapiens_hsa052190.55955569
102FoxO signaling pathway_Homo sapiens_hsa040680.55796760
103Endometrial cancer_Homo sapiens_hsa052130.53475894
104Dilated cardiomyopathy_Homo sapiens_hsa054140.53350689
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53323459
106Glioma_Homo sapiens_hsa052140.53216487
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52150773
108Renin-angiotensin system_Homo sapiens_hsa046140.49916161
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47977649
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47904995
111* Rap1 signaling pathway_Homo sapiens_hsa040150.46300999
112One carbon pool by folate_Homo sapiens_hsa006700.43143808
113Insulin signaling pathway_Homo sapiens_hsa049100.42693941
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41489907
115Systemic lupus erythematosus_Homo sapiens_hsa053220.39703475
116Graft-versus-host disease_Homo sapiens_hsa053320.37747543

Most similar genes based on co-expression Upload to Enrichr

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