TLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13979741
2synaptic vesicle maturation (GO:0016188)4.13476526
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09634356
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98692821
5locomotory exploration behavior (GO:0035641)3.91019792
6cell communication by electrical coupling (GO:0010644)3.79806923
7plasma membrane repair (GO:0001778)3.75972357
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74331350
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.64122401
10regulation of synapse structural plasticity (GO:0051823)3.63570184
11L-amino acid import (GO:0043092)3.58355117
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.57891857
13vocalization behavior (GO:0071625)3.57188889
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.53789051
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.48321616
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.47110163
17amino acid import (GO:0043090)3.45619605
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.44630266
19sodium ion export (GO:0071436)3.43433812
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.42021903
21cell communication involved in cardiac conduction (GO:0086065)3.35394181
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.33112226
23regulation of membrane repolarization (GO:0060306)3.30439987
24positive regulation of synapse maturation (GO:0090129)3.29137136
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.27659790
26activation of protein kinase A activity (GO:0034199)3.25405106
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.25210225
28cardiac myofibril assembly (GO:0055003)3.22536165
29layer formation in cerebral cortex (GO:0021819)3.20774483
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.20004057
31cellular potassium ion homeostasis (GO:0030007)3.18823747
32synaptic vesicle exocytosis (GO:0016079)3.18698005
33membrane depolarization during action potential (GO:0086010)3.17545260
34glutamate secretion (GO:0014047)3.17414529
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16867844
36negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09877039
37protein localization to synapse (GO:0035418)3.09465167
38neuronal ion channel clustering (GO:0045161)3.07075480
39regulation of glutamate receptor signaling pathway (GO:1900449)3.06275331
40proline transport (GO:0015824)3.06227608
41positive regulation of potassium ion transmembrane transport (GO:1901381)3.05801660
42regulation of synaptic vesicle exocytosis (GO:2000300)3.05558705
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03583462
44regulation of synapse maturation (GO:0090128)3.02716341
45cardiac muscle contraction (GO:0060048)2.97081167
46cGMP-mediated signaling (GO:0019934)2.96704987
47exploration behavior (GO:0035640)2.95772376
48* cytoskeletal anchoring at plasma membrane (GO:0007016)2.94331369
49neuronal action potential propagation (GO:0019227)2.93974230
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93562638
51cerebellar granule cell differentiation (GO:0021707)2.89182301
52neurotransmitter secretion (GO:0007269)2.88166907
53regulation of neuronal synaptic plasticity (GO:0048168)2.87050784
54actin-myosin filament sliding (GO:0033275)2.86285705
55muscle filament sliding (GO:0030049)2.86285705
56dendritic spine morphogenesis (GO:0060997)2.84816925
57postsynaptic membrane organization (GO:0001941)2.84144437
58regulation of calcium ion transmembrane transport (GO:1903169)2.83354186
59regulation of calcium ion transmembrane transporter activity (GO:1901019)2.83354186
60cell migration in hindbrain (GO:0021535)2.81364175
61prepulse inhibition (GO:0060134)2.78783546
62myelination in peripheral nervous system (GO:0022011)2.78739863
63peripheral nervous system axon ensheathment (GO:0032292)2.78739863
64regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78701509
65neuromuscular process controlling balance (GO:0050885)2.77848144
66establishment of nucleus localization (GO:0040023)2.76079247
67positive regulation of potassium ion transport (GO:0043268)2.74014569
68regulation of synaptic vesicle transport (GO:1902803)2.73032486
69glycine transport (GO:0015816)2.72419176
70sarcoplasmic reticulum calcium ion transport (GO:0070296)2.71800240
71myofibril assembly (GO:0030239)2.71368352
72potassium ion import (GO:0010107)2.70686487
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.70279810
74regulation of potassium ion transmembrane transporter activity (GO:1901016)2.69540391
75membrane repolarization (GO:0086009)2.67892041
76regulation of potassium ion transmembrane transport (GO:1901379)2.67039027
77regulation of voltage-gated calcium channel activity (GO:1901385)2.66372464
78neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.65255873
79membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.65167330
80positive regulation of dendritic spine development (GO:0060999)2.64956179
81cardiac muscle hypertrophy (GO:0003300)2.64530250
82regulation of cell communication by electrical coupling (GO:0010649)2.63000829
83positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.62234966
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61605616
85regulation of dendritic spine morphogenesis (GO:0061001)2.60596322
86sarcomere organization (GO:0045214)2.60481383
87regulation of actin filament-based movement (GO:1903115)2.59401417
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58357080
89actin-mediated cell contraction (GO:0070252)2.57685779
90dendrite morphogenesis (GO:0048813)2.57060110
91striatum development (GO:0021756)2.56774912
92striated muscle hypertrophy (GO:0014897)2.52845111
93negative regulation of dendrite morphogenesis (GO:0050774)2.52720707
94cerebellar Purkinje cell differentiation (GO:0021702)2.50808574
95regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50162060
96regulation of protein kinase A signaling (GO:0010738)2.50071320
97vesicle transport along microtubule (GO:0047496)2.48954214
98detection of calcium ion (GO:0005513)2.48186327
99positive regulation of dendrite development (GO:1900006)2.47867760
100cardiac conduction (GO:0061337)2.47572641
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.45893051
102cardiac muscle adaptation (GO:0014887)2.45648930
103cardiac muscle hypertrophy in response to stress (GO:0014898)2.45648930
104muscle hypertrophy in response to stress (GO:0003299)2.45648930
105neuron cell-cell adhesion (GO:0007158)2.45455696
106regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45121016
107ventricular cardiac muscle cell action potential (GO:0086005)2.44719749
108membrane depolarization (GO:0051899)2.44685430
109innervation (GO:0060384)2.44407798
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.42724242
111cellular sodium ion homeostasis (GO:0006883)2.42585251
112long-term memory (GO:0007616)2.42576071
113neuron-neuron synaptic transmission (GO:0007270)2.42082397
114central nervous system myelination (GO:0022010)2.41548704
115axon ensheathment in central nervous system (GO:0032291)2.41548704
116potassium ion homeostasis (GO:0055075)2.41337097
117neuron recognition (GO:0008038)2.40502823
118regulation of cation channel activity (GO:2001257)2.40223740
119mating behavior (GO:0007617)2.39931782
120striated muscle contraction (GO:0006941)2.39647793
121cardiac muscle cell action potential (GO:0086001)2.39099072
122glutamate receptor signaling pathway (GO:0007215)2.38929480
123membrane assembly (GO:0071709)2.38681105
124regulation of cardiac muscle cell contraction (GO:0086004)2.38536470
125neurotransmitter-gated ion channel clustering (GO:0072578)2.38373912
126organelle transport along microtubule (GO:0072384)2.38335294
127positive regulation of synaptic transmission, GABAergic (GO:0032230)2.37818956
128regulation of postsynaptic membrane potential (GO:0060078)2.37020502
129cardiac muscle cell action potential involved in contraction (GO:0086002)2.36984907
130axonal fasciculation (GO:0007413)2.36302916
131regulation of synaptic plasticity (GO:0048167)2.35705916
132regulation of dendritic spine development (GO:0060998)2.34753908
133negative regulation of inclusion body assembly (GO:0090084)2.34124701
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32648107
135regulation of relaxation of muscle (GO:1901077)2.31020916
136synaptic vesicle endocytosis (GO:0048488)2.29674505
137regulation of cAMP-dependent protein kinase activity (GO:2000479)2.28964802
138paraxial mesoderm development (GO:0048339)2.28728754
139adherens junction assembly (GO:0034333)2.27780797
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.27659941
141actomyosin structure organization (GO:0031032)2.26149086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94490948
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64338545
3GBX2_23144817_ChIP-Seq_PC3_Human2.60064351
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55780122
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50215118
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50215118
7DROSHA_22980978_ChIP-Seq_HELA_Human2.39805284
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34993101
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22171956
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20511914
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18605006
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17033060
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.14256563
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10529221
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08466320
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.08040506
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.94522709
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.93664832
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90394066
20* EP300_21415370_ChIP-Seq_HL-1_Mouse1.87597174
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.87278092
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85095976
23REST_21632747_ChIP-Seq_MESCs_Mouse1.79472953
24* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75574233
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72828460
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67235444
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65544696
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65408680
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62894303
30AR_21572438_ChIP-Seq_LNCaP_Human1.62489437
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.48569619
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40029075
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.36705508
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36095616
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36023398
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34156921
37ZNF274_21170338_ChIP-Seq_K562_Hela1.33633763
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32762911
39* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32403946
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.30634481
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30617474
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30056426
43KDM2B_26808549_Chip-Seq_K562_Human1.29591393
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27777736
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27407391
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27363997
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25379143
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.24732373
49* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24708668
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24214664
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22423255
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22409672
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.22228556
54* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20938118
55* AR_19668381_ChIP-Seq_PC3_Human1.19481525
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.19447891
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16254282
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15887494
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.15316629
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12641739
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12554611
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12350973
63SMAD3_21741376_ChIP-Seq_HESCs_Human1.11488017
64CLOCK_20551151_ChIP-Seq_293T_Human1.10717996
65* AHR_22903824_ChIP-Seq_MCF-7_Human1.09778426
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.08607867
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08339856
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.07583747
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06428435
70* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06083049
71* CTCF_27219007_Chip-Seq_Bcells_Human1.06023945
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06023156
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05604533
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.05532771
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04181374
76* SMAD4_21741376_ChIP-Seq_HESCs_Human1.04143347
77STAT3_23295773_ChIP-Seq_U87_Human1.03623158
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03568605
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03284164
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03066343
81* SMAD3_21741376_ChIP-Seq_EPCs_Human1.02981218
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02856688
83* ESR2_21235772_ChIP-Seq_MCF-7_Human1.02708651
84* ARNT_22903824_ChIP-Seq_MCF-7_Human1.02331016
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02189137
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01403492
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01379350
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.01317639
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00783947
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00138303
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99651770
92YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98877726
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98849474
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95852405
95TP53_16413492_ChIP-PET_HCT116_Human0.95390702
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94955290
97* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94669605
98* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94669605
99AR_25329375_ChIP-Seq_VCAP_Human0.94080495
100TP53_23651856_ChIP-Seq_MEFs_Mouse0.93161857
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.92656887
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.92586097
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92491043
104* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92209513
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92154956
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91984026
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91189588
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91189588
109* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90250606
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89770823
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89747587
112ZNF263_19887448_ChIP-Seq_K562_Human0.89649558
113* ISL1_27105846_Chip-Seq_CPCs_Mouse0.89443713
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89122711
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.89052914
116BCAT_22108803_ChIP-Seq_LS180_Human0.88650944
117TCF4_23295773_ChIP-Seq_U87_Human0.88640946
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88496023
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87247956
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.87114010
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86833493
122CBX2_27304074_Chip-Seq_ESCs_Mouse0.86162518
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84806018
124* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84678552
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.82599166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.25934560
2MP0000751_myopathy3.42342603
3MP0002837_dystrophic_cardiac_calcinosis3.08888877
4MP0004270_analgesia2.88196487
5MP0002822_catalepsy2.76230306
6MP0003635_abnormal_synaptic_transmissio2.65769854
7MP0003880_abnormal_central_pattern2.47759101
8MP0004084_abnormal_cardiac_muscle2.33496106
9MP0004858_abnormal_nervous_system2.24774527
10MP0003646_muscle_fatigue2.22725759
11MP0004215_abnormal_myocardial_fiber2.21070058
12MP0004145_abnormal_muscle_electrophysio2.18818307
13MP0000749_muscle_degeneration2.15525811
14MP0001968_abnormal_touch/_nociception2.10184296
15MP0009745_abnormal_behavioral_response2.09057979
16MP0002063_abnormal_learning/memory/cond2.06213546
17MP0009046_muscle_twitch1.99999122
18MP0004036_abnormal_muscle_relaxation1.99635528
19MP0002734_abnormal_mechanical_nocicepti1.95960407
20MP0004233_abnormal_muscle_weight1.91646836
21MP0002064_seizures1.87502949
22MP0003879_abnormal_hair_cell1.79297688
23MP0008438_abnormal_cutaneous_collagen1.79133714
24MP0005623_abnormal_meninges_morphology1.75654747
25MP0002272_abnormal_nervous_system1.68952894
26MP0001486_abnormal_startle_reflex1.68232340
27MP0004130_abnormal_muscle_cell1.67059728
28MP0000747_muscle_weakness1.66476983
29MP0005330_cardiomyopathy1.65482939
30MP0002735_abnormal_chemical_nociception1.64895115
31MP0005620_abnormal_muscle_contractility1.64698474
32MP0009780_abnormal_chondrocyte_physiolo1.59495089
33* MP0004087_abnormal_muscle_fiber1.58637288
34MP0002572_abnormal_emotion/affect_behav1.57039017
35MP0005423_abnormal_somatic_nervous1.56144241
36MP0003137_abnormal_impulse_conducting1.55443522
37MP0002736_abnormal_nociception_after1.53547360
38MP0000750_abnormal_muscle_regeneration1.51236778
39MP0002909_abnormal_adrenal_gland1.49395951
40MP0002972_abnormal_cardiac_muscle1.48608558
41MP0002733_abnormal_thermal_nociception1.43732417
42MP0001970_abnormal_pain_threshold1.42916668
43MP0003690_abnormal_glial_cell1.40123157
44MP0006138_congestive_heart_failure1.37456600
45MP0001299_abnormal_eye_distance/1.36088088
46MP0004085_abnormal_heartbeat1.35626689
47MP0003705_abnormal_hypodermis_morpholog1.35231959
48MP0001440_abnormal_grooming_behavior1.34836300
49MP0002269_muscular_atrophy1.32789798
50MP0004484_altered_response_of1.31070847
51MP0002106_abnormal_muscle_physiology1.29579150
52* MP0000759_abnormal_skeletal_muscle1.29379341
53MP0008775_abnormal_heart_ventricle1.29313782
54MP0002067_abnormal_sensory_capabilities1.28593437
55MP0001501_abnormal_sleep_pattern1.28418134
56MP0000013_abnormal_adipose_tissue1.27967923
57MP0010368_abnormal_lymphatic_system1.27501417
58MP0008569_lethality_at_weaning1.24299333
59MP0005670_abnormal_white_adipose1.24028578
60MP0010030_abnormal_orbit_morphology1.22956948
61MP0002108_abnormal_muscle_morphology1.22637021
62MP0003045_fibrosis1.22246831
63MP0004272_abnormal_basement_membrane1.21103520
64MP0005369_muscle_phenotype1.20565885
65MP0005275_abnormal_skin_tensile1.20158488
66MP0003283_abnormal_digestive_organ1.18506126
67MP0004811_abnormal_neuron_physiology1.16166856
68MP0005386_behavior/neurological_phenoty1.15642035
69MP0004924_abnormal_behavior1.15642035
70MP0003329_amyloid_beta_deposits1.15561509
71MP0000733_abnormal_muscle_development1.13344436
72MP0003122_maternal_imprinting1.10394943
73MP0004885_abnormal_endolymph1.10270397
74MP0000920_abnormal_myelination1.10189051
75MP0002184_abnormal_innervation1.10177381
76MP0005666_abnormal_adipose_tissue1.06754142
77MP0003633_abnormal_nervous_system1.06338675
78MP0006276_abnormal_autonomic_nervous1.05758478
79MP0000778_abnormal_nervous_system1.05719326
80MP0000955_abnormal_spinal_cord1.04323442
81MP0008961_abnormal_basal_metabolism1.04189307
82MP0005410_abnormal_fertilization1.02540390
83MP0003279_aneurysm1.02090842
84MP0001544_abnormal_cardiovascular_syste1.00706761
85MP0005385_cardiovascular_system_phenoty1.00706761
86MP0003385_abnormal_body_wall0.99352001
87MP0002882_abnormal_neuron_morphology0.97802177
88MP0002066_abnormal_motor_capabilities/c0.97163497
89MP0005375_adipose_tissue_phenotype0.94928418
90MP0000579_abnormal_nail_morphology0.92425687
91MP0010630_abnormal_cardiac_muscle0.91990793
92MP0005409_darkened_coat_color0.91222947
93MP0005503_abnormal_tendon_morphology0.90027593
94MP0001984_abnormal_olfaction0.89383029
95MP0002971_abnormal_brown_adipose0.88033139
96MP0002557_abnormal_social/conspecific_i0.87535552
97MP0003941_abnormal_skin_development0.87109456
98MP0003566_abnormal_cell_adhesion0.86209396
99MP0005551_abnormal_eye_electrophysiolog0.83909838
100MP0000534_abnormal_ureter_morphology0.83611405
101MP0001177_atelectasis0.83146330
102MP0002295_abnormal_pulmonary_circulatio0.82934959
103MP0003631_nervous_system_phenotype0.82284124
104MP0000428_abnormal_craniofacial_morphol0.82234983
105MP0009672_abnormal_birth_weight0.81931353
106MP0000537_abnormal_urethra_morphology0.81878904
107MP0002896_abnormal_bone_mineralization0.81755132
108MP0000003_abnormal_adipose_tissue0.81477310
109MP0004510_myositis0.81335673
110MP0001958_emphysema0.79814084
111MP0000462_abnormal_digestive_system0.79802936
112MP0001502_abnormal_circadian_rhythm0.79592528
113MP0002234_abnormal_pharynx_morphology0.79126548
114MP0003634_abnormal_glial_cell0.79032726
115MP0003950_abnormal_plasma_membrane0.78178780
116MP0000762_abnormal_tongue_morphology0.77811070
117MP0005595_abnormal_vascular_smooth0.77431229
118MP0004043_abnormal_pH_regulation0.77424324
119MP0005187_abnormal_penis_morphology0.74859217
120MP0002332_abnormal_exercise_endurance0.74323759
121MP0004185_abnormal_adipocyte_glucose0.72337003
122MP0005535_abnormal_body_temperature0.71895255
123MP0000569_abnormal_digit_pigmentation0.71867715

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.52904783
2Sudden death (HP:0001699)4.14459165
3Focal motor seizures (HP:0011153)3.81341445
4Action tremor (HP:0002345)3.51069154
5Abnormality of the calf musculature (HP:0001430)3.44616278
6Muscle fiber splitting (HP:0003555)3.44164072
7Nemaline bodies (HP:0003798)3.41972061
8Exercise-induced myalgia (HP:0003738)3.40878643
9Difficulty running (HP:0009046)3.39949246
10Focal seizures (HP:0007359)3.36808829
11Hyporeflexia of lower limbs (HP:0002600)3.17963697
12Calf muscle hypertrophy (HP:0008981)3.14159885
13Atrial fibrillation (HP:0005110)3.04744437
14Prolonged QT interval (HP:0001657)3.03689666
15Exercise-induced muscle cramps (HP:0003710)2.97282187
16Muscle hypertrophy of the lower extremities (HP:0008968)2.96953600
17Termporal pattern (HP:0011008)2.96374754
18Insidious onset (HP:0003587)2.96374754
19Increased connective tissue (HP:0009025)2.92134073
20Ventricular fibrillation (HP:0001663)2.91788414
21Primary atrial arrhythmia (HP:0001692)2.91080458
22Bundle branch block (HP:0011710)2.90645397
23Round ear (HP:0100830)2.90534191
24Lower limb amyotrophy (HP:0007210)2.83345021
25Difficulty climbing stairs (HP:0003551)2.81733704
26Type 1 muscle fiber predominance (HP:0003803)2.78992502
27Supraventricular tachycardia (HP:0004755)2.70130222
28Supraventricular arrhythmia (HP:0005115)2.69240909
29Myotonia (HP:0002486)2.65676548
30Syncope (HP:0001279)2.62798407
31Distal arthrogryposis (HP:0005684)2.58890243
32Increased variability in muscle fiber diameter (HP:0003557)2.57274068
33EMG: myopathic abnormalities (HP:0003458)2.52919831
34Visual hallucinations (HP:0002367)2.52296599
35Distal lower limb amyotrophy (HP:0008944)2.50320672
36Neurofibrillary tangles (HP:0002185)2.49096136
37Vascular tortuosity (HP:0004948)2.47957710
38Aortic aneurysm (HP:0004942)2.45240438
39Pheochromocytoma (HP:0002666)2.44494933
40Abnormal EKG (HP:0003115)2.43848867
41Obstructive sleep apnea (HP:0002870)2.36793208
42Arterial tortuosity (HP:0005116)2.32762347
43Ventricular arrhythmia (HP:0004308)2.30951155
44Mildly elevated creatine phosphokinase (HP:0008180)2.30009031
45Cerebral aneurysm (HP:0004944)2.29473784
46Ankle clonus (HP:0011448)2.28096032
47Ulnar claw (HP:0001178)2.22795835
48Limited hip movement (HP:0008800)2.21659073
49Subaortic stenosis (HP:0001682)2.20784679
50Abnormality of the left ventricular outflow tract (HP:0011103)2.20784679
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.19838554
52Impaired vibration sensation in the lower limbs (HP:0002166)2.17948491
53Upper limb amyotrophy (HP:0009129)2.17445365
54Distal upper limb amyotrophy (HP:0007149)2.17445365
55Foot dorsiflexor weakness (HP:0009027)2.17303240
56Progressive cerebellar ataxia (HP:0002073)2.17160130
57Broad metatarsal (HP:0001783)2.16899370
58Dysmetric saccades (HP:0000641)2.16318356
59Hammertoe (HP:0001765)2.15152073
60Resting tremor (HP:0002322)2.14894985
61Urinary bladder sphincter dysfunction (HP:0002839)2.14790556
62Central scotoma (HP:0000603)2.14677363
63Urinary urgency (HP:0000012)2.13200744
64Myoglobinuria (HP:0002913)2.13107991
65Abnormality of skeletal muscle fiber size (HP:0012084)2.12889577
66Protrusio acetabuli (HP:0003179)2.11862884
67Dysdiadochokinesis (HP:0002075)2.11622700
68Abnormality of the foot musculature (HP:0001436)2.10546202
69Cerebral inclusion bodies (HP:0100314)2.08345388
70Generalized tonic-clonic seizures (HP:0002069)2.08164299
71Ventricular tachycardia (HP:0004756)2.08068310
72Epileptic encephalopathy (HP:0200134)2.06194220
73Aortic dissection (HP:0002647)2.06090681
74Supranuclear gaze palsy (HP:0000605)2.05738452
75Depression (HP:0000716)2.04626190
76Lipoatrophy (HP:0100578)2.04619934
77Postural instability (HP:0002172)2.01476591
78Hip contracture (HP:0003273)2.01148729
79Scapular winging (HP:0003691)2.00274239
80Hypoplasia of the iris (HP:0007676)2.00156261
81Abnormal atrioventricular conduction (HP:0005150)1.99988717
82Atonic seizures (HP:0010819)1.99962178
83Premature rupture of membranes (HP:0001788)1.99793655
84Abnormality of the lower motor neuron (HP:0002366)1.99002306
85Ulnar deviation of the wrist (HP:0003049)1.98558241
86Heart block (HP:0012722)1.96630537
87Febrile seizures (HP:0002373)1.96176167
88Atrophic scars (HP:0001075)1.94052645
89Poor eye contact (HP:0000817)1.92733185
90Coronal craniosynostosis (HP:0004440)1.92266104
91Neuroendocrine neoplasm (HP:0100634)1.92247734
92Shallow orbits (HP:0000586)1.91171932
93Neck muscle weakness (HP:0000467)1.91062063
94Overgrowth (HP:0001548)1.89897704
95Bell-shaped thorax (HP:0001591)1.89877128
96Asymmetric septal hypertrophy (HP:0001670)1.89521956
97Onion bulb formation (HP:0003383)1.89107263
98Aplasia involving bones of the upper limbs (HP:0009823)1.88851115
99Aplasia of the phalanges of the hand (HP:0009802)1.88851115
100Aplasia involving bones of the extremities (HP:0009825)1.88851115
101Hypoventilation (HP:0002791)1.88482093
102Steppage gait (HP:0003376)1.88332124
103Abnormal social behavior (HP:0012433)1.87536398
104Impaired social interactions (HP:0000735)1.87536398
105Turricephaly (HP:0000262)1.86743409
106Rapidly progressive (HP:0003678)1.86532944
107Right ventricular cardiomyopathy (HP:0011663)1.86469512
108Absence seizures (HP:0002121)1.85813239
109Bradycardia (HP:0001662)1.83942800
110Soft skin (HP:0000977)1.83645856
111Calcaneovalgus deformity (HP:0001848)1.82546714
112Wormian bones (HP:0002645)1.82427654
113EMG: neuropathic changes (HP:0003445)1.81997271
114Lower limb muscle weakness (HP:0007340)1.80877144
115Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80584883
116Bowel diverticulosis (HP:0005222)1.80087807
117Bronchomalacia (HP:0002780)1.79367703
118Neonatal short-limb short stature (HP:0008921)1.78976685
119Dysmetria (HP:0001310)1.78633750
120Torticollis (HP:0000473)1.78542361
121Insomnia (HP:0100785)1.78102049
122Muscle fiber inclusion bodies (HP:0100299)1.77899067
123Achilles tendon contracture (HP:0001771)1.77676763
124Distal lower limb muscle weakness (HP:0009053)1.77382902
125Bladder diverticulum (HP:0000015)1.77358347
126Anxiety (HP:0000739)1.76465607
127Abnormal eating behavior (HP:0100738)1.76193659
128Abnormality of the ischium (HP:0003174)1.76031945
129Spinal rigidity (HP:0003306)1.75051712
130Atrioventricular block (HP:0001678)1.74804397
131Mild short stature (HP:0003502)1.71730066
132Truncal ataxia (HP:0002078)1.68680488
133Frequent falls (HP:0002359)1.68366834
134Mitral valve prolapse (HP:0001634)1.67543254
135Diplopia (HP:0000651)1.66798815
136Abnormality of binocular vision (HP:0011514)1.66798815
137Fragile skin (HP:0001030)1.64895784
138Lymphangioma (HP:0100764)1.64623816
139Deformed tarsal bones (HP:0008119)1.64092140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.05811472
2EPHA42.96636234
3PRKD32.90013547
4MAP3K92.67308870
5LMTK22.47994138
6PINK12.34578517
7PHKG12.28583755
8PHKG22.28583755
9PDK42.20192851
10PDK32.20192851
11NTRK12.17641997
12DAPK22.12234571
13KSR22.04350786
14PAK62.00750155
15MAP3K41.99033152
16TRIB31.95365879
17MINK11.91528709
18TTN1.85491835
19LATS21.77333080
20STK381.74554199
21CASK1.70303274
22MARK11.67360796
23OBSCN1.58675863
24PDK21.57353247
25RIPK11.48612351
26CAMKK11.43830546
27NEK11.40030079
28DMPK1.39335805
29WNK41.36960404
30LATS11.35447641
31NTRK21.31839046
32ICK1.27589965
33CAMK1G1.21623593
34MAP3K21.21161911
35PDGFRA1.20249527
36EPHB21.19573393
37WNK11.14487491
38CAMK2B1.11597798
39MAP2K41.10151512
40DDR21.09590175
41PTK21.08942893
42RET1.08884006
43PKN21.07851881
44MOS1.05803592
45CDK51.05500756
46KSR11.02713119
47PTK2B1.02519818
48PAK30.98425763
49PAK20.96124633
50TYRO30.96009866
51CAMK2G0.94997212
52AKT30.94359601
53FER0.93309905
54GRK50.92602558
55EEF2K0.92503128
56PNCK0.92348464
57PRPF4B0.89017374
58MUSK0.88274976
59STK390.88119964
60SGK2230.86839254
61SGK4940.86839254
62CAMK1D0.85161484
63CDC42BPA0.84598525
64MET0.84337735
65LIMK10.80636231
66CAMK10.79787592
67STK110.79023740
68PRKCH0.78214273
69CDK190.75785712
70CAMK2A0.73691225
71MAP2K70.73649382
72FGFR20.73582617
73ROCK10.71582082
74PDPK10.71384364
75RIPK40.71309849
76PDGFRB0.70802786
77MAP3K70.70596599
78TAOK10.70082380
79MAPK100.69404364
80DAPK10.68816555
81MARK20.67869766
82SGK30.66640420
83PDK10.66566365
84NEK60.66417289
85MAP2K10.64318723
86MAPK130.64285946
87MAP3K130.64119680
88PLK20.63017551
89MAPK70.62449686
90PRKCG0.62165050
91BMX0.61980330
92UHMK10.61964645
93SGK10.61658960
94CDK150.60088882
95WNK30.59124213
96DAPK30.58737034
97CAMK2D0.58630118
98CDK140.57873743
99SGK20.57795452
100CDK180.57495717
101ALK0.57136152
102PRKAA20.54939650
103SIK20.54771824
104PRKD10.54385271
105PIK3CA0.53870708
106NEK90.53182354
107TGFBR20.52795316
108PKN10.52765244
109DYRK1A0.51439554
110OXSR10.51392821
111CAMKK20.50869579
112CAMK40.50629647
113RPS6KA30.50322375
114PRKAA10.49977288
115MYLK0.49422495
116ARAF0.48836305
117PRKG10.48374453
118BRAF0.48198868
119ROCK20.47873230
120CDK11A0.47422116
121TNIK0.45888932
122MAPK120.45399909
123PRKCE0.43604791
124RPS6KA20.43327262
125MAP3K10.42496021
126MTOR0.40962591

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31983183
2Synaptic vesicle cycle_Homo sapiens_hsa047212.20927154
3Olfactory transduction_Homo sapiens_hsa047402.11258463
4Circadian entrainment_Homo sapiens_hsa047132.06060737
5Dilated cardiomyopathy_Homo sapiens_hsa054142.00325465
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99658216
7Nicotine addiction_Homo sapiens_hsa050331.96249182
8Cardiac muscle contraction_Homo sapiens_hsa042601.85425251
9Long-term potentiation_Homo sapiens_hsa047201.83363287
10GABAergic synapse_Homo sapiens_hsa047271.79159503
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78041824
12Salivary secretion_Homo sapiens_hsa049701.73062154
13Glutamatergic synapse_Homo sapiens_hsa047241.71305015
14Amphetamine addiction_Homo sapiens_hsa050311.70797271
15Gastric acid secretion_Homo sapiens_hsa049711.69389221
16Morphine addiction_Homo sapiens_hsa050321.68666051
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68082885
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67779368
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67200616
20Dopaminergic synapse_Homo sapiens_hsa047281.63547357
21Renin secretion_Homo sapiens_hsa049241.61942768
22Oxytocin signaling pathway_Homo sapiens_hsa049211.61694990
23Cholinergic synapse_Homo sapiens_hsa047251.61627718
24Insulin secretion_Homo sapiens_hsa049111.58348112
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51464388
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50646610
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46589503
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45080744
29Calcium signaling pathway_Homo sapiens_hsa040201.40617250
30Vitamin B6 metabolism_Homo sapiens_hsa007501.38560351
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.37289952
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36478652
33Cocaine addiction_Homo sapiens_hsa050301.30054693
34Gap junction_Homo sapiens_hsa045401.27852767
35GnRH signaling pathway_Homo sapiens_hsa049121.25389121
36Phototransduction_Homo sapiens_hsa047441.24005138
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21188365
38cAMP signaling pathway_Homo sapiens_hsa040241.18816021
39Type II diabetes mellitus_Homo sapiens_hsa049301.18255063
40Taste transduction_Homo sapiens_hsa047421.17178908
41Long-term depression_Homo sapiens_hsa047301.13065541
42Estrogen signaling pathway_Homo sapiens_hsa049151.10619289
43Nitrogen metabolism_Homo sapiens_hsa009101.09676627
44Dorso-ventral axis formation_Homo sapiens_hsa043201.08740739
45Glucagon signaling pathway_Homo sapiens_hsa049221.05669635
46Glioma_Homo sapiens_hsa052141.03018093
47Axon guidance_Homo sapiens_hsa043601.02025975
48Melanogenesis_Homo sapiens_hsa049161.01239143
49Fatty acid biosynthesis_Homo sapiens_hsa000611.01080074
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99037557
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.98895506
52Serotonergic synapse_Homo sapiens_hsa047260.98435154
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95213612
54PPAR signaling pathway_Homo sapiens_hsa033200.93089164
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92665361
56Circadian rhythm_Homo sapiens_hsa047100.87852172
57Insulin signaling pathway_Homo sapiens_hsa049100.86255292
58Propanoate metabolism_Homo sapiens_hsa006400.85952333
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.84624329
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82919969
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82660003
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80919333
63Thyroid hormone synthesis_Homo sapiens_hsa049180.79864432
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79442524
65ErbB signaling pathway_Homo sapiens_hsa040120.76264603
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.74784163
67Collecting duct acid secretion_Homo sapiens_hsa049660.74583668
68Tight junction_Homo sapiens_hsa045300.74297201
69mTOR signaling pathway_Homo sapiens_hsa041500.74272277
70* Focal adhesion_Homo sapiens_hsa045100.73478262
71Pancreatic secretion_Homo sapiens_hsa049720.73301771
72Arginine and proline metabolism_Homo sapiens_hsa003300.72373789
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72218055
74AMPK signaling pathway_Homo sapiens_hsa041520.71844482
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70271632
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.68822159
77Oocyte meiosis_Homo sapiens_hsa041140.68353037
78ECM-receptor interaction_Homo sapiens_hsa045120.66919873
79Bile secretion_Homo sapiens_hsa049760.65857948
80Arginine biosynthesis_Homo sapiens_hsa002200.64626698
81* Rap1 signaling pathway_Homo sapiens_hsa040150.63896530
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63496434
83Protein digestion and absorption_Homo sapiens_hsa049740.61678208
84Inositol phosphate metabolism_Homo sapiens_hsa005620.60706586
85MAPK signaling pathway_Homo sapiens_hsa040100.60062866
86Histidine metabolism_Homo sapiens_hsa003400.59484066
87Choline metabolism in cancer_Homo sapiens_hsa052310.58945378
88VEGF signaling pathway_Homo sapiens_hsa043700.58940204
89Hedgehog signaling pathway_Homo sapiens_hsa043400.58557980
90Basal cell carcinoma_Homo sapiens_hsa052170.57458412
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57391435
92Endometrial cancer_Homo sapiens_hsa052130.55534684
93Fatty acid metabolism_Homo sapiens_hsa012120.53956478
94Insulin resistance_Homo sapiens_hsa049310.53866285
95Pyruvate metabolism_Homo sapiens_hsa006200.53555898
96Carbon metabolism_Homo sapiens_hsa012000.51741275
97Wnt signaling pathway_Homo sapiens_hsa043100.51553431
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.51105757
99Amoebiasis_Homo sapiens_hsa051460.50421609
100Proteoglycans in cancer_Homo sapiens_hsa052050.50233915
101Ras signaling pathway_Homo sapiens_hsa040140.49836821
102Adherens junction_Homo sapiens_hsa045200.47886103
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47882002
104Endocytosis_Homo sapiens_hsa041440.47740977
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47188893
106Butanoate metabolism_Homo sapiens_hsa006500.46822394
107HIF-1 signaling pathway_Homo sapiens_hsa040660.45684711
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45611400
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44973709
110Renal cell carcinoma_Homo sapiens_hsa052110.44859187
111Ovarian steroidogenesis_Homo sapiens_hsa049130.44714938
112Hippo signaling pathway_Homo sapiens_hsa043900.44230753
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43743521
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42260524
115Prion diseases_Homo sapiens_hsa050200.41745683
116Lysine degradation_Homo sapiens_hsa003100.41471481
117beta-Alanine metabolism_Homo sapiens_hsa004100.40636552
118TGF-beta signaling pathway_Homo sapiens_hsa043500.39948400

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