TLR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of macroautophagy (GO:0016242)5.77425046
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.31348347
3microglial cell activation (GO:0001774)5.15230047
4auditory receptor cell stereocilium organization (GO:0060088)5.08813190
5energy homeostasis (GO:0097009)5.06174254
6detection of other organism (GO:0098543)4.94897810
7post-embryonic morphogenesis (GO:0009886)4.88652365
8regulation of B cell receptor signaling pathway (GO:0050855)4.85190976
9neutrophil activation involved in immune response (GO:0002283)4.80938570
10positive thymic T cell selection (GO:0045059)4.45223718
11sulfate transmembrane transport (GO:1902358)4.42339587
12detection of bacterium (GO:0016045)4.29337344
13cellular anion homeostasis (GO:0030002)4.24920845
14* macrophage activation (GO:0042116)4.10588951
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.09352759
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00296279
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.00296279
18modulation by symbiont of host immune response (GO:0052553)4.00296279
19positive regulation by symbiont of host defense response (GO:0052509)4.00296279
20modulation by symbiont of host defense response (GO:0052031)4.00296279
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00296279
22* detection of biotic stimulus (GO:0009595)3.97331084
23neutrophil mediated immunity (GO:0002446)3.96483926
24positive regulation of gamma-delta T cell activation (GO:0046645)3.95809417
25immunoglobulin mediated immune response (GO:0016064)3.91550569
26trivalent inorganic anion homeostasis (GO:0072506)3.84553365
27phosphate ion homeostasis (GO:0055062)3.84553365
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.84536955
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82508937
30myeloid cell activation involved in immune response (GO:0002275)3.81482897
31neutrophil activation (GO:0042119)3.81417439
32negative regulation of mast cell activation (GO:0033004)3.78224915
33production of molecular mediator involved in inflammatory response (GO:0002532)3.74964789
34sulfate transport (GO:0008272)3.73713273
35leukocyte aggregation (GO:0070486)3.73336136
36positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.71887012
37regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.70295335
38response to interleukin-15 (GO:0070672)3.58684799
39negative regulation of T cell mediated immunity (GO:0002710)3.57910169
40positive T cell selection (GO:0043368)3.54159590
41granulocyte activation (GO:0036230)3.51607048
42myeloid leukocyte mediated immunity (GO:0002444)3.50475346
43T-helper 1 type immune response (GO:0042088)3.45262596
44positive regulation of mast cell activation (GO:0033005)3.43061439
45regulation of activation of Janus kinase activity (GO:0010533)3.41899881
46negative regulation of leukocyte mediated immunity (GO:0002704)3.38385498
47* detection of molecule of bacterial origin (GO:0032490)3.33632119
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.32983118
49* positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.32469708
50response to muramyl dipeptide (GO:0032495)3.30043839
51cellular response to interleukin-15 (GO:0071350)3.25702529
52leukocyte migration involved in inflammatory response (GO:0002523)3.24505456
53regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.22758272
54negative regulation of phagocytosis (GO:0050765)3.22313750
55defense response to protozoan (GO:0042832)3.21799805
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.21209647
57interferon-gamma-mediated signaling pathway (GO:0060333)3.19765904
58positive regulation of cellular amide metabolic process (GO:0034250)3.15727197
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.15660188
60regulation of mast cell activation (GO:0033003)3.15337868
61inner ear receptor stereocilium organization (GO:0060122)3.15165646
62lateral ventricle development (GO:0021670)3.14705306
63response to pheromone (GO:0019236)3.13555158
64glycoside metabolic process (GO:0016137)3.13432171
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13364071
66negative regulation of meiosis (GO:0045835)3.13227986
67B cell homeostasis (GO:0001782)3.12646526
68positive regulation of B cell differentiation (GO:0045579)3.10281600
69B cell mediated immunity (GO:0019724)3.10039955
70regulation of mast cell activation involved in immune response (GO:0033006)3.09554546
71antigen processing and presentation via MHC class Ib (GO:0002475)3.08838246
72maintenance of gastrointestinal epithelium (GO:0030277)3.08609245
73positive regulation of toll-like receptor signaling pathway (GO:0034123)3.08146416
74regulation of tolerance induction (GO:0002643)3.07970500
75regulation of B cell differentiation (GO:0045577)3.05787524
76germinal center formation (GO:0002467)3.05655176
77antigen processing and presentation of endogenous antigen (GO:0019883)3.05279680
78interferon-gamma production (GO:0032609)3.02591393
79B cell receptor signaling pathway (GO:0050853)3.01604565
80negative thymic T cell selection (GO:0045060)3.00583623
81positive regulation of macrophage cytokine production (GO:0060907)2.98724328
82negative T cell selection (GO:0043383)2.97489910
83T cell migration (GO:0072678)2.96678535
84dendritic cell migration (GO:0036336)2.96550053
85regulation of macrophage cytokine production (GO:0010935)2.94628311
86regulation of interferon-beta biosynthetic process (GO:0045357)2.94502809
87negative regulation of interleukin-17 production (GO:0032700)2.94247521
88regulation of leukocyte degranulation (GO:0043300)2.94153384
89positive regulation of mast cell degranulation (GO:0043306)2.93794324
90positive regulation of mast cell activation involved in immune response (GO:0033008)2.93794324
91positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.90863068
92positive regulation of interferon-beta production (GO:0032728)2.88984003
93negative regulation of T-helper cell differentiation (GO:0045623)2.88911610
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88911610
95* myeloid leukocyte activation (GO:0002274)2.87990510
96regulation of T cell tolerance induction (GO:0002664)2.87631348
97positive regulation of interferon-alpha production (GO:0032727)2.87185170
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86393641
99positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86187834
100regulation of interleukin-8 biosynthetic process (GO:0045414)2.85095424
101* regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84962187
102macrophage activation involved in immune response (GO:0002281)2.83223327
103negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.82650419
104positive regulation of antigen processing and presentation (GO:0002579)2.80578633
105I-kappaB phosphorylation (GO:0007252)2.79841109
106positive regulation of uterine smooth muscle contraction (GO:0070474)2.79584900
107negative regulation of interleukin-12 production (GO:0032695)2.79064745
108response to host immune response (GO:0052572)2.77232435
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77232435
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72628131
111thymic T cell selection (GO:0045061)2.72224656
112regulation of gamma-delta T cell activation (GO:0046643)2.72182642
113B cell proliferation (GO:0042100)2.72000298
114regulation of interferon-alpha production (GO:0032647)2.71912740
115lymphocyte homeostasis (GO:0002260)2.71338661
116response to type I interferon (GO:0034340)2.69141410
117negative regulation of B cell proliferation (GO:0030889)2.67532972
118positive regulation of interleukin-1 beta secretion (GO:0050718)2.66601366
119prostate gland growth (GO:0060736)2.65250705
120type I interferon signaling pathway (GO:0060337)2.63493693
121cellular response to type I interferon (GO:0071357)2.63493693
122negative regulation of cell killing (GO:0031342)2.62718591
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62718591
124positive regulation of heat generation (GO:0031652)2.62676396
125bicarbonate transport (GO:0015701)2.61819545
126negative regulation of granulocyte differentiation (GO:0030853)2.61242783
127T cell selection (GO:0045058)2.59171691
128negative regulation of response to extracellular stimulus (GO:0032105)2.58931290
129negative regulation of response to nutrient levels (GO:0032108)2.58931290
130positive regulation of CREB transcription factor activity (GO:0032793)2.57179865
131regulation of interleukin-12 biosynthetic process (GO:0045075)2.56943674
132regulation of gamma-delta T cell differentiation (GO:0045586)2.56797695
133cellular extravasation (GO:0045123)2.55566383
134regulation of mast cell degranulation (GO:0043304)2.55277634
135response to peptidoglycan (GO:0032494)2.54992037
136modulation by virus of host process (GO:0019054)2.54984336
137* detection of external biotic stimulus (GO:0098581)2.54596271
138positive regulation of neurological system process (GO:0031646)2.54211208
139cell proliferation involved in metanephros development (GO:0072203)2.53392800
140monocyte chemotaxis (GO:0002548)2.51830649
141positive regulation of protein homooligomerization (GO:0032464)2.51167073
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50918389
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50918389
144regulation of interferon-gamma biosynthetic process (GO:0045072)2.50014566
145neuron remodeling (GO:0016322)2.48412572
146regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48310456
147histone H3-K9 modification (GO:0061647)2.47781137
148T cell homeostasis (GO:0043029)2.47408476
149modulation by symbiont of host cellular process (GO:0044068)2.47347575
150respiratory burst (GO:0045730)2.46822103
151regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46376475
152response to host (GO:0075136)2.45297542
153response to host defenses (GO:0052200)2.45297542
154response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45297542
155positive regulation of interleukin-1 secretion (GO:0050716)2.44928187
156polyketide metabolic process (GO:0030638)16.3564667
157doxorubicin metabolic process (GO:0044598)16.3564667
158daunorubicin metabolic process (GO:0044597)16.3564667
159aminoglycoside antibiotic metabolic process (GO:0030647)10.5486131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.68709953
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.48471124
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.79434045
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.69860513
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47435133
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.39510473
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.16563783
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83330135
9EZH2_22144423_ChIP-Seq_EOC_Human2.75965734
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56758334
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.51485761
12VDR_24763502_ChIP-Seq_THP-1_Human2.33723296
13RUNX_20019798_ChIP-Seq_JUKART_Human2.30274429
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28811307
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25873790
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23436498
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20184010
18GBX2_23144817_ChIP-Seq_PC3_Human2.16957446
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15321237
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11466576
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08640039
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06679590
23MAF_26560356_Chip-Seq_TH1_Human1.98203744
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96715978
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.94908442
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.93038575
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88491763
28SCL_19346495_ChIP-Seq_HPC-7_Human1.82641329
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82086400
30GATA1_22025678_ChIP-Seq_K562_Human1.77905649
31GATA3_27048872_Chip-Seq_THYMUS_Human1.74357927
32VDR_24787735_ChIP-Seq_THP-1_Human1.69901643
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68993529
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67764916
35RXR_22108803_ChIP-Seq_LS180_Human1.65285209
36UTX_26944678_Chip-Seq_JUKART_Human1.64839316
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53187902
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51611913
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50311480
40TCF7_22412390_ChIP-Seq_EML_Mouse1.49971968
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47479045
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46428019
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45318486
44DROSHA_22980978_ChIP-Seq_HELA_Human1.44982169
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42731550
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39756859
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.37902442
48MYC_22102868_ChIP-Seq_BL_Human1.37890655
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37435030
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35377276
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34878938
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32773876
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27699571
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26010030
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25726563
56MAF_26560356_Chip-Seq_TH2_Human1.25024720
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.24715466
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22607777
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22015266
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21797811
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.21053268
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18214283
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17934681
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17803056
65MYB_26560356_Chip-Seq_TH2_Human1.16473639
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15642165
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15045483
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14975076
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14713776
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13007128
71GATA1_19941826_ChIP-Seq_K562_Human1.12846668
72KDM2B_26808549_Chip-Seq_DND41_Human1.12544090
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.12406652
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12226934
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.11936988
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.10498920
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10226360
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09757609
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09657837
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09602257
81P300_19829295_ChIP-Seq_ESCs_Human1.09263449
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08954893
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08954893
84SPI1_23127762_ChIP-Seq_K562_Human1.08395601
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07905205
86* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07462498
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07036510
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06709835
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05934300
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.03604446
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02874568
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02533084
93GATA2_19941826_ChIP-Seq_K562_Human1.02397794
94P53_22387025_ChIP-Seq_ESCs_Mouse1.01783825
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01104936
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.00715559
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00693880
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99898316
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.99366650
100PU1_27457419_Chip-Seq_LIVER_Mouse0.98456282
101NMYC_18555785_Chip-Seq_ESCs_Mouse0.98226892
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98186015
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98051256
104OCT4_18555785_Chip-Seq_ESCs_Mouse0.98044237
105* SPI1_23547873_ChIP-Seq_NB4_Human0.97302786
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.96758629
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96708718
108SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96463286
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95000561
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94441296
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.94379588
112PU_27001747_Chip-Seq_BMDM_Mouse0.94008551
113MYB_26560356_Chip-Seq_TH1_Human0.93993869
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93863459
115RNF2_27304074_Chip-Seq_ESCs_Mouse0.93766506
116RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92690003
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92514315
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92356727
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92120017
120ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91239801
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.89641028
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89421233
123STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88973354
124ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88762226
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88684804
126AR_25329375_ChIP-Seq_VCAP_Human0.87063834
127SMRT_27268052_Chip-Seq_Bcells_Human0.86716206
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86626349
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86387619
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86323613
131GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86111998
132MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85146938
133VDR_21846776_ChIP-Seq_THP-1_Human0.84802889
134GATA3_26560356_Chip-Seq_TH2_Human0.84744163
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84282350
136ZFX_18555785_Chip-Seq_ESCs_Mouse0.84214343
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84078406
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83427103
139SOX2_18555785_Chip-Seq_ESCs_Mouse0.83284797
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83017296
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.82759882
142VDR_22108803_ChIP-Seq_LS180_Human0.82659214
143P300_18555785_Chip-Seq_ESCs_Mouse0.82397505
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81863849
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81469914
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77659060
147KDM2B_26808549_Chip-Seq_JURKAT_Human0.76958396
148RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73458883
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.64869466
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64799764
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.62733355
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.62118123
153* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.61984098
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61599972
155NCOR1_26117541_ChIP-Seq_K562_Human0.60774539
156TFEB_21752829_ChIP-Seq_HELA_Human0.60362734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.47202227
2MP0003878_abnormal_ear_physiology5.47202227
3MP0008004_abnormal_stomach_pH5.09944836
4MP0001835_abnormal_antigen_presentation3.46638982
5MP0001790_abnormal_immune_system3.20243929
6MP0005387_immune_system_phenotype3.20243929
7MP0005645_abnormal_hypothalamus_physiol2.91700457
8MP0005671_abnormal_response_to2.83426155
9* MP0001800_abnormal_humoral_immune2.68263742
10MP0002277_abnormal_respiratory_mucosa2.57233255
11MP0003879_abnormal_hair_cell2.52499970
12MP0008260_abnormal_autophagy2.45259962
13MP0002148_abnormal_hypersensitivity_rea2.42442014
14MP0002452_abnormal_antigen_presenting2.41480176
15MP0005000_abnormal_immune_tolerance2.36341239
16MP0009785_altered_susceptibility_to2.31373011
17MP0009697_abnormal_copulation2.30931723
18MP0000678_abnormal_parathyroid_gland2.30516829
19MP0000685_abnormal_immune_system2.27500183
20MP0002419_abnormal_innate_immunity2.17867360
21* MP0002723_abnormal_immune_serum2.15810970
22MP0003303_peritoneal_inflammation2.03720553
23MP0003436_decreased_susceptibility_to2.02779842
24MP0001986_abnormal_taste_sensitivity2.02254448
25MP0001819_abnormal_immune_cell2.01873805
26MP0002420_abnormal_adaptive_immunity2.01656755
27MP0005025_abnormal_response_to1.97511171
28MP0006292_abnormal_olfactory_placode1.92141497
29MP0003763_abnormal_thymus_physiology1.88847701
30MP0005451_abnormal_body_composition1.86649591
31MP0002396_abnormal_hematopoietic_system1.82360406
32MP0004742_abnormal_vestibular_system1.75728351
33MP0004883_abnormal_blood_vessel1.71723721
34MP0009278_abnormal_bone_marrow1.71528589
35MP0005310_abnormal_salivary_gland1.65149477
36MP0000465_gastrointestinal_hemorrhage1.55635998
37MP0004510_myositis1.54580183
38MP0000716_abnormal_immune_system1.53943539
39MP0004381_abnormal_hair_follicle1.49180816
40MP0002398_abnormal_bone_marrow1.48990481
41MP0005397_hematopoietic_system_phenotyp1.48085125
42MP0001545_abnormal_hematopoietic_system1.48085125
43MP0009764_decreased_sensitivity_to1.46263872
44MP0006082_CNS_inflammation1.43214567
45MP0003045_fibrosis1.42399640
46MP0005464_abnormal_platelet_physiology1.39361374
47MP0005164_abnormal_response_to1.39104972
48MP0003690_abnormal_glial_cell1.38837017
49MP0002132_abnormal_respiratory_system1.38585720
50MP0001845_abnormal_inflammatory_respons1.35907220
51MP0000566_synostosis1.34585883
52MP0002998_abnormal_bone_remodeling1.32733741
53MP0003724_increased_susceptibility_to1.32309370
54MP0003656_abnormal_erythrocyte_physiolo1.27624977
55MP0001485_abnormal_pinna_reflex1.26106073
56MP0003941_abnormal_skin_development1.25013968
57MP0000604_amyloidosis1.24307445
58MP0003191_abnormal_cellular_cholesterol1.23051550
59MP0002405_respiratory_system_inflammati1.22233888
60MP0002006_tumorigenesis1.19622959
61MP0004782_abnormal_surfactant_physiolog1.18464204
62MP0002429_abnormal_blood_cell1.18052368
63MP0001533_abnormal_skeleton_physiology1.16226356
64MP0003300_gastrointestinal_ulcer1.15184895
65MP0000689_abnormal_spleen_morphology1.14839922
66MP0000343_altered_response_to1.13840481
67MP0005423_abnormal_somatic_nervous1.13668763
68MP0010155_abnormal_intestine_physiology1.13068406
69MP0001851_eye_inflammation1.12095875
70MP0001853_heart_inflammation1.11191166
71MP0002722_abnormal_immune_system1.08044618
72MP0003646_muscle_fatigue1.07464479
73MP0003866_abnormal_defecation1.01920538
74MP0004947_skin_inflammation0.98033527
75MP0009333_abnormal_splenocyte_physiolog0.97360196
76MP0002735_abnormal_chemical_nociception0.97234321
77MP0003172_abnormal_lysosome_physiology0.96134855
78MP0005257_abnormal_intraocular_pressure0.95166647
79MP0000703_abnormal_thymus_morphology0.94102360
80MP0003221_abnormal_cardiomyocyte_apopto0.90073909
81MP0005075_abnormal_melanosome_morpholog0.89891067
82MP0009763_increased_sensitivity_to0.88537209
83MP0001873_stomach_inflammation0.87995865
84MP0005166_decreased_susceptibility_to0.87836239
85MP0008469_abnormal_protein_level0.87719807
86MP0000681_abnormal_thyroid_gland0.83554178
87MP0005171_absent_coat_pigmentation0.83220696
88MP0003566_abnormal_cell_adhesion0.82994939
89MP0004808_abnormal_hematopoietic_stem0.82726895
90MP0003787_abnormal_imprinting0.80238939
91MP0000858_altered_metastatic_potential0.79301383
92MP0000470_abnormal_stomach_morphology0.75973773
93MP0000249_abnormal_blood_vessel0.75612250
94MP0004130_abnormal_muscle_cell0.74477096
95MP0002332_abnormal_exercise_endurance0.73845633
96MP0000569_abnormal_digit_pigmentation0.73360174
97MP0002098_abnormal_vibrissa_morphology0.73026719
98MP0001663_abnormal_digestive_system0.72822188
99MP0008874_decreased_physiological_sensi0.72188781
100MP0003448_altered_tumor_morphology0.72180657
101MP0002166_altered_tumor_susceptibility0.72071972
102MP0006276_abnormal_autonomic_nervous0.71890060
103MP0004484_altered_response_of0.71778528
104MP0002928_abnormal_bile_duct0.71559417
105MP0000371_diluted_coat_color0.71203243
106MP0003795_abnormal_bone_structure0.70168898
107MP0002933_joint_inflammation0.70070969
108MP0009765_abnormal_xenobiotic_induced0.69467389
109MP0003091_abnormal_cell_migration0.69045889
110MP0010386_abnormal_urinary_bladder0.68497239
111MP0005167_abnormal_blood-brain_barrier0.68062642
112MP0003868_abnormal_feces_composition0.67880443
113MP0003453_abnormal_keratinocyte_physiol0.67264485
114MP0000015_abnormal_ear_pigmentation0.66866151
115MP0005646_abnormal_pituitary_gland0.66085070
116MP0006054_spinal_hemorrhage0.65962044
117MP0003075_altered_response_to0.64765959
118MP0002163_abnormal_gland_morphology0.63204741
119MP0005058_abnormal_lysosome_morphology0.62813781
120MP0002075_abnormal_coat/hair_pigmentati0.62599752
121MP0003329_amyloid_beta_deposits0.62200781
122MP0005174_abnormal_tail_pigmentation0.62158057
123MP0005390_skeleton_phenotype0.62077241
124MP0001501_abnormal_sleep_pattern0.61690388
125MP0001486_abnormal_startle_reflex0.59845336
126MP0001324_abnormal_eye_pigmentation0.59752672
127MP0005647_abnormal_sex_gland0.59686331
128MP0003183_abnormal_peptide_metabolism0.59227954
129MP0002009_preneoplasia0.58930072
130MP0002138_abnormal_hepatobiliary_system0.57401101
131MP0005376_homeostasis/metabolism_phenot0.55876379
132MP0009840_abnormal_foam_cell0.55154338
133MP0003828_pulmonary_edema0.54840840
134MP0005388_respiratory_system_phenotype0.53869445
135MP0002133_abnormal_respiratory_system0.53869445

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)7.89041132
2Alopecia of scalp (HP:0002293)6.92839905
3Unilateral renal agenesis (HP:0000122)6.68949497
4Bilateral sensorineural hearing impairment (HP:0008619)5.92812443
5Chronic otitis media (HP:0000389)5.91358526
6Follicular hyperkeratosis (HP:0007502)5.66428602
7Cheilitis (HP:0100825)5.61334037
8Abnormality of dental color (HP:0011073)5.00207621
9Absent eyebrow (HP:0002223)4.58314506
10Gastrointestinal infarctions (HP:0005244)4.33013236
11Absent eyelashes (HP:0000561)4.21535491
12Recurrent corneal erosions (HP:0000495)4.09492434
13Keratoconjunctivitis sicca (HP:0001097)4.03463407
14T lymphocytopenia (HP:0005403)3.86730588
15Recurrent abscess formation (HP:0002722)3.85398249
16Chronic sinusitis (HP:0011109)3.79144906
17Spontaneous hematomas (HP:0007420)3.72032420
18Keratoconjunctivitis (HP:0001096)3.71445181
19Encephalitis (HP:0002383)3.56700598
20Hyperphosphatemia (HP:0002905)3.56333967
21Eczematoid dermatitis (HP:0000976)3.56150249
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.54165068
23Absent/shortened dynein arms (HP:0200106)3.54165068
24Arterial thrombosis (HP:0004420)3.32297148
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.29458003
26Hemoptysis (HP:0002105)3.28817084
27Peritonitis (HP:0002586)3.28419388
28Tetany (HP:0001281)3.27622613
29Abolished electroretinogram (ERG) (HP:0000550)3.24428376
30Recurrent bacterial skin infections (HP:0005406)3.23000520
31Chest pain (HP:0100749)3.22793885
32Ectropion (HP:0000656)3.20753312
33Mitral stenosis (HP:0001718)3.14911503
34Lymphopenia (HP:0001888)3.14489333
35Prostate neoplasm (HP:0100787)3.11982689
36Erythroderma (HP:0001019)3.11696941
37Mediastinal lymphadenopathy (HP:0100721)3.10318443
38Agammaglobulinemia (HP:0004432)2.99854003
39Leukocytosis (HP:0001974)2.99149526
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.98215503
41Recurrent cutaneous fungal infections (HP:0011370)2.87935164
42Chronic mucocutaneous candidiasis (HP:0002728)2.87935164
43Blepharitis (HP:0000498)2.87555013
44Urticaria (HP:0001025)2.83586891
45Vasculitis (HP:0002633)2.82992111
46Chronic diarrhea (HP:0002028)2.81005118
47Pulmonary embolism (HP:0002204)2.79351860
48Abnormality of T cells (HP:0002843)2.77216026
49Epistaxis (HP:0000421)2.75982329
50Anorexia (HP:0002039)2.72497806
51Gastrointestinal stroma tumor (HP:0100723)2.71323142
52Renal dysplasia (HP:0000110)2.71270290
53Recurrent fungal infections (HP:0002841)2.70793605
54Amyloidosis (HP:0011034)2.70434651
55Keratitis (HP:0000491)2.68582062
56Increased IgE level (HP:0003212)2.68079551
57Abnormality of liposaccharide metabolism (HP:0010968)2.66524403
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.66524403
59Abnormality of glycolipid metabolism (HP:0010969)2.66524403
60Stomatitis (HP:0010280)2.64665186
61Gangrene (HP:0100758)2.63448379
62Recurrent pneumonia (HP:0006532)2.56218767
63Episodic fever (HP:0001954)2.54249251
64Recurrent sinusitis (HP:0011108)2.52243137
65Retrobulbar optic neuritis (HP:0100654)2.49541610
66Optic neuritis (HP:0100653)2.49541610
67Abnormality of the peritoneum (HP:0002585)2.47097915
68Osteomyelitis (HP:0002754)2.46935677
69Abnormality of the prostate (HP:0008775)2.45921207
70Neoplasm of the lung (HP:0100526)2.45426707
71Myositis (HP:0100614)2.45397575
72Meningitis (HP:0001287)2.44947466
73Recurrent skin infections (HP:0001581)2.44553459
74Recurrent gram-negative bacterial infections (HP:0005420)2.44021332
75Small epiphyses (HP:0010585)2.41555494
76Abnormality of the pleura (HP:0002103)2.40589757
77Granulocytopenia (HP:0001913)2.38207327
78Recurrent viral infections (HP:0004429)2.35872633
79Pustule (HP:0200039)2.35571904
80Hypochromic microcytic anemia (HP:0004840)2.35084622
81Obstructive lung disease (HP:0006536)2.34711119
82Chronic obstructive pulmonary disease (HP:0006510)2.34711119
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.33943182
84Palmoplantar hyperkeratosis (HP:0000972)2.30803685
85Inflammation of the large intestine (HP:0002037)2.29123227
86Abnormality of the endocardium (HP:0004306)2.28802850
87Plagiocephaly (HP:0001357)2.28794246
88Palmar hyperkeratosis (HP:0010765)2.28623380
89Orchitis (HP:0100796)2.26407910
90Eosinophilia (HP:0001880)2.24309739
91Autoimmune thrombocytopenia (HP:0001973)2.22349401
92Erythema (HP:0010783)2.20404710
93Increased cerebral lipofuscin (HP:0011813)2.20345489
94Slow saccadic eye movements (HP:0000514)2.20272320
95Recurrent lower respiratory tract infections (HP:0002783)2.19432321
96Sepsis (HP:0100806)2.19156528
97Glomerulopathy (HP:0100820)2.16580170
98Gingivitis (HP:0000230)2.15883264
99Hypochromic anemia (HP:0001931)2.15785482
100Viral hepatitis (HP:0006562)2.14151128
101Systemic lupus erythematosus (HP:0002725)2.11587308
102Absent hair (HP:0002298)2.11166696
103Neoplasm of the respiratory system (HP:0100606)2.09077069
104Colitis (HP:0002583)2.08769047
105Pulmonary infiltrates (HP:0002113)2.08690668
106Subacute progressive viral hepatitis (HP:0006572)2.08097838
107Recurrent bronchitis (HP:0002837)2.07490703
108Periodontitis (HP:0000704)2.07310990
109Vertebral arch anomaly (HP:0008438)2.07066549
110Gastrointestinal inflammation (HP:0004386)2.04301169
111Increased IgM level (HP:0003496)2.03956668
112Autoimmune hemolytic anemia (HP:0001890)2.02901359
113Prolonged bleeding time (HP:0003010)2.02797058
114Abnormality of the renal collecting system (HP:0004742)2.02723270
115Abnormality of T cell physiology (HP:0011840)2.01529998
116Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00908170
117Acute hepatic failure (HP:0006554)2.00152255
118Vertigo (HP:0002321)2.00078469
119Amaurosis fugax (HP:0100576)1.99977269
120Thrombophlebitis (HP:0004418)1.99319823
121Chronic hepatic failure (HP:0100626)1.99232078
122Polyneuropathy (HP:0001271)1.99089809
123Basal ganglia calcification (HP:0002135)1.98850372
124Cellulitis (HP:0100658)1.97714592
125Arthropathy (HP:0003040)1.97249335
126Microcytic anemia (HP:0001935)1.96048553
127Duplicated collecting system (HP:0000081)1.95923940
128Hypergammaglobulinemia (HP:0010702)1.95482785
129Elevated erythrocyte sedimentation rate (HP:0003565)1.94922216
130Skin ulcer (HP:0200042)1.93577148
131Loss of speech (HP:0002371)1.93230724
132Abnormality of eosinophils (HP:0001879)1.91805693
133Ectopic kidney (HP:0000086)1.91715136
134Petechiae (HP:0000967)1.90905412
135Disinhibition (HP:0000734)1.90277988
136Panhypogammaglobulinemia (HP:0003139)1.89342924
137Acne (HP:0001061)1.88266922
138Fatigue (HP:0012378)1.85547193
139Hematochezia (HP:0002573)1.84647776
140Hyperactive renin-angiotensin system (HP:0000841)1.84263803
141Abnormality of macrophages (HP:0004311)1.83089020
142Abnormal ciliary motility (HP:0012262)1.82187659
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81641759
144Myocardial infarction (HP:0001658)1.81403274
145Gingival bleeding (HP:0000225)1.79100327
146Emphysema (HP:0002097)1.78626824
147Abnormality of calcium-phosphate metabolism (HP:0100530)1.77463675
148Metabolic alkalosis (HP:0200114)1.77342076
149Bone pain (HP:0002653)1.74295547
150Abnormality of T cell number (HP:0011839)1.74018142
151Abnormal respiratory epithelium morphology (HP:0012253)1.72725173
152Abnormal respiratory motile cilium morphology (HP:0005938)1.72725173
153IgA deficiency (HP:0002720)1.72637948
154Abnormal biliary tract physiology (HP:0012439)1.72569029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK38.04171571
2SIK25.46215544
3SIK14.67716787
4MARK33.33059800
5MAP4K13.19720221
6TXK3.04333170
7MAP2K32.82132651
8MAP3K142.80680176
9MAP3K132.02685620
10TYK21.99838169
11IRAK41.94431423
12BLK1.85682322
13IRAK31.71005556
14JAK31.69379869
15IKBKE1.67998227
16EPHA21.64899261
17RIPK41.55018192
18MAP3K31.48224460
19JAK11.46612862
20MAP3K21.44854010
21LATS11.35244097
22MATK1.35025511
23MAP3K11.33857152
24KSR21.33767065
25PAK41.32632410
26PRPF4B1.32190397
27PIK3CG1.25243000
28TBK11.21158077
29ADRBK21.20589053
30ZAP701.19976600
31SYK1.19675155
32TAOK11.19443579
33IKBKB1.18805904
34KIT1.17673010
35TEC1.13017247
36MAP3K111.11735587
37STK101.09590071
38CSF1R1.06086093
39MAP3K61.05363683
40ITK1.04792163
41MAP3K121.04724445
42HCK1.04504645
43CSK1.02981560
44CDK81.01633164
45BTK1.01053307
46TGFBR21.00553819
47MARK20.98044450
48LYN0.96939890
49LRRK20.88266977
50TNK20.87763381
51ZAK0.86124880
52PDK10.81952806
53SGK20.81665623
54LCK0.81093042
55CAMKK20.78296703
56FGFR30.76079597
57MAP3K50.76068105
58WNK10.75290840
59PTK2B0.72009851
60SGK30.69366754
61CLK10.69349323
62GRK70.69129099
63RAF10.69021624
64PRKCQ0.67513228
65PDPK10.67372629
66CHUK0.66771152
67FGFR40.65034559
68STK38L0.64113306
69RPS6KA40.63297349
70FES0.63217261
71MAP2K40.62780452
72MST40.62744573
73YES10.62301695
74KSR10.61616357
75TNIK0.60484024
76GRK60.59926242
77NLK0.57190918
78CSNK1A1L0.56482744
79IRAK20.54318651
80PIM10.51518645
81DYRK1B0.51489538
82CDC42BPA0.51354759
83ACVR1B0.51164136
84STK380.51144747
85PTK60.50850068
86BMPR20.50674701
87STK110.48815150
88STK40.48721629
89TAOK20.47855389
90MAP2K60.47106052
91EIF2AK20.46837991
92RET0.46459303
93CSNK1D0.45716738
94NEK90.45632576
95TAOK30.44694684
96HIPK20.43699624
97MAPK120.43409014
98CDK190.43084365
99FGR0.42427764
100BMPR1B0.41403904
101PRKD20.41235704
102GRK10.39728979
103CAMK40.39542839
104CAMK10.39270514
105NUAK10.39142816
106IRAK10.38685877
107EPHB10.38081576
108EPHA30.38057263
109CAMKK10.37634185
110DYRK30.37466773
111PKN10.37375327
112INSRR0.37227607
113PRKAA20.37016303
114ERN10.36757203
115JAK20.36196656
116CDK60.35778165
117MAPK110.35236974
118FRK0.35112020
119MAPKAPK20.34002031
120MOS0.33867832
121INSR0.33269881
122STK30.32356648
123MAP3K70.32168451
124GRK50.31754870
125EGFR0.30228894
126PRKCH0.29715559
127FYN0.28922953
128ALK0.28687946
129MAPK70.28368576
130CDK120.26085773
131PRKCD0.25663358
132SGK10.25478095
133RPS6KA60.24584900
134BRD40.24402913
135ABL10.23828216
136MAPK130.23637775
137CAMK1D0.21904990
138RPS6KC10.21362034
139RPS6KL10.21362034

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.69846023
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.99034443
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.62741965
4Leishmaniasis_Homo sapiens_hsa051402.48764942
5Hematopoietic cell lineage_Homo sapiens_hsa046402.35231189
6* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35028123
7Measles_Homo sapiens_hsa051622.25440780
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22185012
9B cell receptor signaling pathway_Homo sapiens_hsa046622.20671352
10Osteoclast differentiation_Homo sapiens_hsa043802.11932385
11Staphylococcus aureus infection_Homo sapiens_hsa051501.96871239
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90651891
13T cell receptor signaling pathway_Homo sapiens_hsa046601.87765665
14Graft-versus-host disease_Homo sapiens_hsa053321.86825478
15African trypanosomiasis_Homo sapiens_hsa051431.81453251
16Allograft rejection_Homo sapiens_hsa053301.76822541
17Mineral absorption_Homo sapiens_hsa049781.64963766
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59205131
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55034002
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54064382
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49380294
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46564881
23Influenza A_Homo sapiens_hsa051641.46132366
24Herpes simplex infection_Homo sapiens_hsa051681.46114602
25Pertussis_Homo sapiens_hsa051331.43443015
26* Tuberculosis_Homo sapiens_hsa051521.41689484
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38809316
28TNF signaling pathway_Homo sapiens_hsa046681.38512230
29Malaria_Homo sapiens_hsa051441.34874350
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34290169
31Toxoplasmosis_Homo sapiens_hsa051451.30261856
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.28195057
33Non-small cell lung cancer_Homo sapiens_hsa052231.27852894
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23586944
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23558097
36Chemokine signaling pathway_Homo sapiens_hsa040621.22264439
37Autoimmune thyroid disease_Homo sapiens_hsa053201.21933500
38Salmonella infection_Homo sapiens_hsa051321.17152598
39Antigen processing and presentation_Homo sapiens_hsa046121.16917118
40Rheumatoid arthritis_Homo sapiens_hsa053231.10378033
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09745473
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05840751
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00195238
44Hepatitis B_Homo sapiens_hsa051610.98516410
45Apoptosis_Homo sapiens_hsa042100.97854262
46Notch signaling pathway_Homo sapiens_hsa043300.96698834
47Legionellosis_Homo sapiens_hsa051340.95991301
48Asthma_Homo sapiens_hsa053100.95726317
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94827675
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92287093
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.89927472
52Shigellosis_Homo sapiens_hsa051310.89609896
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85252594
54VEGF signaling pathway_Homo sapiens_hsa043700.84320742
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83942848
56Hepatitis C_Homo sapiens_hsa051600.83326779
57Dorso-ventral axis formation_Homo sapiens_hsa043200.83279660
58Type II diabetes mellitus_Homo sapiens_hsa049300.83154038
59Type I diabetes mellitus_Homo sapiens_hsa049400.83085700
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.83061760
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82537615
62Acute myeloid leukemia_Homo sapiens_hsa052210.79777126
63Other glycan degradation_Homo sapiens_hsa005110.79105579
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78795742
65Phagosome_Homo sapiens_hsa041450.77592270
66Viral myocarditis_Homo sapiens_hsa054160.76623579
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.74232505
68Lysosome_Homo sapiens_hsa041420.69507495
69Calcium signaling pathway_Homo sapiens_hsa040200.68352253
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.68333934
71HTLV-I infection_Homo sapiens_hsa051660.67303716
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66615003
73Lysine degradation_Homo sapiens_hsa003100.65974818
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65654238
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65377046
76Prolactin signaling pathway_Homo sapiens_hsa049170.65274086
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63520205
78Amoebiasis_Homo sapiens_hsa051460.63021533
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62477300
80Pancreatic cancer_Homo sapiens_hsa052120.61975203
81Endometrial cancer_Homo sapiens_hsa052130.60683170
82Chronic myeloid leukemia_Homo sapiens_hsa052200.60546831
83Platelet activation_Homo sapiens_hsa046110.60101807
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59718262
85HIF-1 signaling pathway_Homo sapiens_hsa040660.58722816
86Axon guidance_Homo sapiens_hsa043600.57395093
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57201109
88Viral carcinogenesis_Homo sapiens_hsa052030.57063636
89Endocytosis_Homo sapiens_hsa041440.56454324
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.56203338
91GnRH signaling pathway_Homo sapiens_hsa049120.56194496
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55505390
93Epstein-Barr virus infection_Homo sapiens_hsa051690.55357408
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54595870
95MAPK signaling pathway_Homo sapiens_hsa040100.54543399
96Renal cell carcinoma_Homo sapiens_hsa052110.54489451
97mTOR signaling pathway_Homo sapiens_hsa041500.54150572
98Nicotine addiction_Homo sapiens_hsa050330.52446328
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50313782
100Inositol phosphate metabolism_Homo sapiens_hsa005620.50218721
101Melanoma_Homo sapiens_hsa052180.49541115
102Insulin resistance_Homo sapiens_hsa049310.47291220
103Ras signaling pathway_Homo sapiens_hsa040140.47177978
104Choline metabolism in cancer_Homo sapiens_hsa052310.46986683
105FoxO signaling pathway_Homo sapiens_hsa040680.45933459
106Prostate cancer_Homo sapiens_hsa052150.42644368
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41788479
108Morphine addiction_Homo sapiens_hsa050320.40935796
109Taste transduction_Homo sapiens_hsa047420.40708364
110Glioma_Homo sapiens_hsa052140.38769434
111MicroRNAs in cancer_Homo sapiens_hsa052060.38507146
112Regulation of autophagy_Homo sapiens_hsa041400.37670334
113Rap1 signaling pathway_Homo sapiens_hsa040150.37596688
114Sphingolipid metabolism_Homo sapiens_hsa006000.37544723
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.37046385
116Colorectal cancer_Homo sapiens_hsa052100.36941060
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.36518031
118ABC transporters_Homo sapiens_hsa020100.36165202
119ErbB signaling pathway_Homo sapiens_hsa040120.35354676
120Serotonergic synapse_Homo sapiens_hsa047260.32119431
121Estrogen signaling pathway_Homo sapiens_hsa049150.31791564
122Ovarian steroidogenesis_Homo sapiens_hsa049130.31723702
123Adherens junction_Homo sapiens_hsa045200.31675681
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31186097
125Small cell lung cancer_Homo sapiens_hsa052220.29617427
126Complement and coagulation cascades_Homo sapiens_hsa046100.29171794

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