TLR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.73123880
2modulation by symbiont of host immune response (GO:0052553)6.63489332
3positive regulation by symbiont of host defense response (GO:0052509)6.63489332
4modulation by symbiont of host defense response (GO:0052031)6.63489332
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.63489332
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.63489332
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.63489332
8neutrophil activation involved in immune response (GO:0002283)5.40209735
9macrophage activation involved in immune response (GO:0002281)5.24847470
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.99020462
11negative regulation of cell killing (GO:0031342)4.99020462
12* regulation of interferon-beta biosynthetic process (GO:0045357)4.96255769
13response to peptidoglycan (GO:0032494)4.80799384
14microglial cell activation (GO:0001774)4.66490783
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.66454396
16response to host immune response (GO:0052572)4.66454396
17* positive regulation of interferon-alpha production (GO:0032727)4.43247968
18* detection of external biotic stimulus (GO:0098581)4.42144887
19response to host (GO:0075136)4.25699380
20response to host defenses (GO:0052200)4.25699380
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.25699380
22detection of bacterium (GO:0016045)4.24758747
23* detection of other organism (GO:0098543)4.24758747
24* regulation of interferon-alpha production (GO:0032647)4.16373547
25immunoglobulin mediated immune response (GO:0016064)4.10563399
26respiratory burst (GO:0045730)4.05738548
27regulation of gamma-delta T cell activation (GO:0046643)4.03036197
28* detection of biotic stimulus (GO:0009595)3.97289420
29positive regulation of cellular amide metabolic process (GO:0034250)3.91806583
30* positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.86486709
31regulation of B cell receptor signaling pathway (GO:0050855)3.83766076
32myeloid cell activation involved in immune response (GO:0002275)3.76802882
33pinocytosis (GO:0006907)3.72617868
34neutrophil activation (GO:0042119)3.69902762
35positive regulation of antigen processing and presentation (GO:0002579)3.69556720
36cellular extravasation (GO:0045123)3.67960056
37* macrophage activation (GO:0042116)3.67265880
38granulocyte activation (GO:0036230)3.59716485
39positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.52216249
40myeloid leukocyte mediated immunity (GO:0002444)3.45507830
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.42284048
42negative regulation of mast cell activation (GO:0033004)3.40953954
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38179348
44regulation of mast cell activation (GO:0033003)3.35202891
45leukocyte migration involved in inflammatory response (GO:0002523)3.33255444
46regulation of gamma-delta T cell differentiation (GO:0045586)3.32777911
47leukocyte aggregation (GO:0070486)3.32095362
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29226720
49regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.28231922
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27405560
51superoxide anion generation (GO:0042554)3.23938998
52* positive regulation of interferon-beta production (GO:0032728)3.22748940
53positive regulation of mast cell activation (GO:0033005)3.21709436
54negative regulation of T cell mediated immunity (GO:0002710)3.21292824
55regulation of T-helper 2 cell differentiation (GO:0045628)3.21253427
56regulation of tolerance induction (GO:0002643)3.19222939
57positive regulation of monocyte chemotaxis (GO:0090026)3.18254576
58germinal center formation (GO:0002467)3.17580556
59neutrophil mediated immunity (GO:0002446)3.17322797
60* detection of molecule of bacterial origin (GO:0032490)3.15427009
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14677550
62regulation of antigen processing and presentation (GO:0002577)3.13827596
63positive regulation of B cell differentiation (GO:0045579)3.13362862
64regulation of mononuclear cell migration (GO:0071675)3.09499783
65regulation of mast cell degranulation (GO:0043304)3.09364509
66negative regulation of leukocyte mediated immunity (GO:0002704)3.09342278
67negative regulation of erythrocyte differentiation (GO:0045647)3.09130984
68positive regulation of gamma-delta T cell activation (GO:0046645)3.08982262
69* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08756179
70regulation of mast cell activation involved in immune response (GO:0033006)3.07724716
71response to interferon-alpha (GO:0035455)3.04887179
72* regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03963566
73phagocytosis, engulfment (GO:0006911)3.01919694
74regulation of T cell tolerance induction (GO:0002664)3.01579597
75antigen processing and presentation of endogenous antigen (GO:0019883)2.99249151
76positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.98794956
77* regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.98652208
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97062872
79regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96433487
80negative regulation of granulocyte differentiation (GO:0030853)2.94382978
81natural killer cell mediated cytotoxicity (GO:0042267)2.92148723
82natural killer cell mediated immunity (GO:0002228)2.92148723
83apoptotic cell clearance (GO:0043277)2.91286694
84* myeloid leukocyte activation (GO:0002274)2.90671661
85positive regulation of mast cell activation involved in immune response (GO:0033008)2.89265276
86positive regulation of mast cell degranulation (GO:0043306)2.89265276
87hydrogen peroxide biosynthetic process (GO:0050665)2.88894799
88response to muramyl dipeptide (GO:0032495)2.88546696
89positive regulation of leukocyte degranulation (GO:0043302)2.88164058
90regulation of monocyte chemotaxis (GO:0090025)2.87564705
91negative regulation of lipid storage (GO:0010888)2.87079035
92positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.86847979
93B cell mediated immunity (GO:0019724)2.86629342
94neutrophil migration (GO:1990266)2.86261630
95dendritic cell migration (GO:0036336)2.86136113
96positive regulation of type 2 immune response (GO:0002830)2.85630144
97regulation of cholesterol storage (GO:0010885)2.85453426
98antigen processing and presentation via MHC class Ib (GO:0002475)2.85384504
99B cell receptor signaling pathway (GO:0050853)2.83169969
100positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81557047
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.80690097
102* I-kappaB phosphorylation (GO:0007252)2.79362478
103* positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.78892183
104myeloid dendritic cell activation (GO:0001773)2.78479254
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77996446
106response to interleukin-15 (GO:0070672)2.76189328
107positive regulation of chemokine secretion (GO:0090197)2.74816480
108negative regulation of cytokine production involved in immune response (GO:0002719)2.74808370
109leukocyte mediated cytotoxicity (GO:0001909)2.74381431
110positive regulation of tolerance induction (GO:0002645)2.73339529
111dendritic cell chemotaxis (GO:0002407)2.73332036
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73330670
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73330670
114interferon-gamma-mediated signaling pathway (GO:0060333)2.72487621
115* positive regulation of chemokine production (GO:0032722)2.72196976
116regulation of regulated secretory pathway (GO:1903305)2.71826277
117positive regulation of lymphocyte migration (GO:2000403)2.71516009
118response to type I interferon (GO:0034340)2.71280860
119cellular response to type I interferon (GO:0071357)2.69544874
120type I interferon signaling pathway (GO:0060337)2.69544874
121* positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68827408
122regulation of B cell differentiation (GO:0045577)2.67434316
123positive regulation of interleukin-1 beta secretion (GO:0050718)2.67110040
124reactive oxygen species biosynthetic process (GO:1903409)2.66508265
125regulation of interleukin-6 biosynthetic process (GO:0045408)2.66430212
126cytokine secretion (GO:0050663)2.66063524
127regulation of type 2 immune response (GO:0002828)2.65685532
128positive regulation of chemokine biosynthetic process (GO:0045080)2.65651668
129negative regulation of toll-like receptor signaling pathway (GO:0034122)2.65209930
130negative regulation of type 2 immune response (GO:0002829)2.64644681
131regulation of leukocyte degranulation (GO:0043300)2.63713543
132myeloid dendritic cell differentiation (GO:0043011)2.63633491
133cellular response to thyroid hormone stimulus (GO:0097067)2.63074914
134positive regulation of macrophage differentiation (GO:0045651)2.62998433
135neutrophil chemotaxis (GO:0030593)2.62703917
136* positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60916655
137defense response to protozoan (GO:0042832)2.60532148
138positive regulation of T cell migration (GO:2000406)2.59700553
139positive regulation of natural killer cell differentiation (GO:0032825)2.59565986
140* positive regulation of tumor necrosis factor production (GO:0032760)2.58571003
141negative regulation of interleukin-12 production (GO:0032695)2.58411755
142cellular response to interferon-alpha (GO:0035457)2.58318780
143dendritic cell differentiation (GO:0097028)2.58034943
144response to protozoan (GO:0001562)2.58016599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.30040064
2* IRF8_21731497_ChIP-ChIP_J774_Mouse6.06077479
3* IRF8_22096565_ChIP-ChIP_GC-B_Human5.88253926
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.39192184
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.21625005
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.99910624
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.80351316
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71791950
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40520571
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.20345319
11* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.19287865
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14202397
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88746459
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.67459787
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59981382
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.55708739
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47136106
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33661930
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.31952690
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28823681
21* SPI1_23547873_ChIP-Seq_NB4_Human2.10228548
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00429491
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.98778436
24SCL_19346495_ChIP-Seq_HPC-7_Human1.97154059
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95160124
26* GATA2_21666600_ChIP-Seq_HMVEC_Human1.90969442
27VDR_24787735_ChIP-Seq_THP-1_Human1.90862352
28* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.85015796
29SPI1_23127762_ChIP-Seq_K562_Human1.81192878
30* PU_27001747_Chip-Seq_BMDM_Mouse1.80320309
31* RUNX_20019798_ChIP-Seq_JUKART_Human1.78969696
32VDR_24763502_ChIP-Seq_THP-1_Human1.66948522
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61193551
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.56763171
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56619407
36MYB_26560356_Chip-Seq_TH2_Human1.56102847
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53412782
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.48780670
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47357024
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46836621
41TCF7_22412390_ChIP-Seq_EML_Mouse1.46294148
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.46280393
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44252812
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44069248
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41915256
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40347622
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39314881
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.38306396
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38064959
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36349982
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31494961
52CJUN_26792858_Chip-Seq_BT549_Human1.30802597
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30241734
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28755687
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27323150
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.26551045
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25728786
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24047078
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24047078
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23206105
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23206105
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22788025
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22448908
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21762149
65MAF_26560356_Chip-Seq_TH1_Human1.21208104
66MYB_26560356_Chip-Seq_TH1_Human1.20643821
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20341968
68GATA1_22025678_ChIP-Seq_K562_Human1.19255611
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18791385
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.17246796
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15995391
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15768000
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15111869
74KDM2B_26808549_Chip-Seq_DND41_Human1.13146404
75GATA1_19941826_ChIP-Seq_K562_Human1.13103326
76* SOX2_20726797_ChIP-Seq_SW620_Human1.12791305
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05763296
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05325973
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03858454
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03202174
81GATA3_26560356_Chip-Seq_TH2_Human1.02997714
82VDR_21846776_ChIP-Seq_THP-1_Human1.01510804
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01462107
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00798297
85* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00271327
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99676939
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99636981
88MAF_26560356_Chip-Seq_TH2_Human0.98453433
89GATA3_27048872_Chip-Seq_THYMUS_Human0.98096949
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97006527
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96725140
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94764476
93MYC_22102868_ChIP-Seq_BL_Human0.93413501
94GATA2_19941826_ChIP-Seq_K562_Human0.93319419
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93013539
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92183902
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91843085
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91243468
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90769016
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89708268
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88065285
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.87087204
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85835868
104* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85281638
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83264869
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.82594529
107CLOCK_20551151_ChIP-Seq_293T_Human0.80884755
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.80786119
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79346683
110* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79069071
111* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78515597
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78345256
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78286011
114BRD4_25478319_ChIP-Seq_HGPS_Human0.78002176
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77413383
116LXR_22158963_ChIP-Seq_LIVER_Mouse0.77324069
117TFEB_21752829_ChIP-Seq_HELA_Human0.77004776
118UTX_26944678_Chip-Seq_JUKART_Human0.76984088
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76318486
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75737206
121* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74841066
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71861753
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71217807
124SMRT_27268052_Chip-Seq_Bcells_Human0.70953050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation3.83929387
2MP0005058_abnormal_lysosome_morphology3.36506614
3MP0003436_decreased_susceptibility_to3.30653557
4MP0002148_abnormal_hypersensitivity_rea3.10404166
5* MP0002419_abnormal_innate_immunity3.09774843
6MP0009785_altered_susceptibility_to3.01504000
7MP0003303_peritoneal_inflammation2.67040259
8* MP0005000_abnormal_immune_tolerance2.66026371
9MP0003191_abnormal_cellular_cholesterol2.57687190
10MP0008438_abnormal_cutaneous_collagen2.47097884
11* MP0005025_abnormal_response_to2.45415747
12* MP0006082_CNS_inflammation2.37731345
13MP0008260_abnormal_autophagy2.34332013
14* MP0002452_abnormal_antigen_presenting2.32931871
15* MP0003724_increased_susceptibility_to2.32820781
16MP0001790_abnormal_immune_system2.28794544
17MP0005387_immune_system_phenotype2.28794544
18MP0003172_abnormal_lysosome_physiology2.23781771
19MP0005464_abnormal_platelet_physiology2.21809540
20MP0005451_abnormal_body_composition2.11080920
21MP0000343_altered_response_to2.10376736
22MP0005671_abnormal_response_to2.09258618
23MP0000569_abnormal_digit_pigmentation2.07942085
24MP0000685_abnormal_immune_system2.07424433
25MP0001800_abnormal_humoral_immune2.07346332
26* MP0002723_abnormal_immune_serum2.03727202
27* MP0001533_abnormal_skeleton_physiology1.99780369
28MP0004510_myositis1.97654905
29* MP0001819_abnormal_immune_cell1.90780968
30* MP0002420_abnormal_adaptive_immunity1.89061549
31MP0003300_gastrointestinal_ulcer1.88569796
32MP0003448_altered_tumor_morphology1.78418723
33MP0009278_abnormal_bone_marrow1.70849971
34MP0002006_tumorigenesis1.65721331
35* MP0001845_abnormal_inflammatory_respons1.65279254
36MP0001853_heart_inflammation1.64161021
37* MP0002405_respiratory_system_inflammati1.62410550
38MP0000858_altered_metastatic_potential1.59965658
39MP0002998_abnormal_bone_remodeling1.56999241
40MP0003279_aneurysm1.56651725
41MP0002166_altered_tumor_susceptibility1.53616969
42MP0010155_abnormal_intestine_physiology1.52548804
43MP0004947_skin_inflammation1.51056247
44MP0006054_spinal_hemorrhage1.50094972
45* MP0003075_altered_response_to1.44885299
46* MP0009764_decreased_sensitivity_to1.43713372
47* MP0008469_abnormal_protein_level1.42205522
48MP0005174_abnormal_tail_pigmentation1.42014826
49MP0001958_emphysema1.40199911
50MP0009840_abnormal_foam_cell1.35516690
51MP0010307_abnormal_tumor_latency1.33259209
52MP0005167_abnormal_blood-brain_barrier1.32264216
53MP0005397_hematopoietic_system_phenotyp1.31538509
54MP0001545_abnormal_hematopoietic_system1.31538509
55MP0003763_abnormal_thymus_physiology1.30750857
56* MP0000716_abnormal_immune_system1.30645210
57MP0003566_abnormal_cell_adhesion1.29545932
58MP0005310_abnormal_salivary_gland1.26162953
59* MP0003828_pulmonary_edema1.25788204
60MP0003183_abnormal_peptide_metabolism1.23907254
61MP0002254_reproductive_system_inflammat1.19888667
62* MP0005164_abnormal_response_to1.19648816
63* MP0003690_abnormal_glial_cell1.18479083
64MP0003705_abnormal_hypodermis_morpholog1.17180736
65MP0002933_joint_inflammation1.16687780
66MP0000015_abnormal_ear_pigmentation1.16685306
67MP0002332_abnormal_exercise_endurance1.16535047
68* MP0005166_decreased_susceptibility_to1.16206403
69* MP0002398_abnormal_bone_marrow1.15533528
70MP0000767_abnormal_smooth_muscle1.14501784
71* MP0005390_skeleton_phenotype1.13719935
72MP0000604_amyloidosis1.13391851
73MP0000371_diluted_coat_color1.13312002
74MP0009333_abnormal_splenocyte_physiolog1.12609843
75* MP0000689_abnormal_spleen_morphology1.10986662
76MP0004808_abnormal_hematopoietic_stem1.09850218
77MP0005171_absent_coat_pigmentation1.09649703
78MP0003045_fibrosis1.09647827
79MP0002277_abnormal_respiratory_mucosa1.07840811
80MP0004782_abnormal_surfactant_physiolog1.07322946
81* MP0002429_abnormal_blood_cell1.07081049
82MP0002396_abnormal_hematopoietic_system1.05031901
83MP0003866_abnormal_defecation1.03111988
84MP0005076_abnormal_cell_differentiation1.00764682
85MP0002877_abnormal_melanocyte_morpholog0.98113943
86MP0003329_amyloid_beta_deposits0.95961652
87* MP0000249_abnormal_blood_vessel0.95810081
88* MP0000465_gastrointestinal_hemorrhage0.95571634
89* MP0002722_abnormal_immune_system0.94902288
90MP0001851_eye_inflammation0.93485340
91MP0005275_abnormal_skin_tensile0.92211299
92MP0004381_abnormal_hair_follicle0.91542876
93MP0003221_abnormal_cardiomyocyte_apopto0.90794836
94MP0000490_abnormal_crypts_of0.90113700
95MP0001873_stomach_inflammation0.88619273
96* MP0004883_abnormal_blood_vessel0.88613092
97MP0003091_abnormal_cell_migration0.85260451
98MP0009763_increased_sensitivity_to0.83721440
99MP0000703_abnormal_thymus_morphology0.83635252
100MP0005023_abnormal_wound_healing0.83583905
101* MP0003795_abnormal_bone_structure0.81836576
102MP0000920_abnormal_myelination0.80295772
103MP0008004_abnormal_stomach_pH0.79885382
104MP0001879_abnormal_lymphatic_vessel0.78840237
105MP0001542_abnormal_bone_strength0.76713760
106MP0001663_abnormal_digestive_system0.74265925
107MP0000372_irregular_coat_pigmentation0.74076602
108MP0001915_intracranial_hemorrhage0.74041679
109MP0009765_abnormal_xenobiotic_induced0.73539973
110MP0003656_abnormal_erythrocyte_physiolo0.72434144
111MP0002295_abnormal_pulmonary_circulatio0.71239939
112MP0000733_abnormal_muscle_development0.70568044
113MP0003453_abnormal_keratinocyte_physiol0.69827927
114MP0008874_decreased_physiological_sensi0.67488272
115MP0005165_increased_susceptibility_to0.55780779

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.75184236
2Eczematoid dermatitis (HP:0000976)6.33059826
3Recurrent bacterial skin infections (HP:0005406)5.93554378
4Systemic lupus erythematosus (HP:0002725)5.19296860
5Recurrent gram-negative bacterial infections (HP:0005420)5.14029649
6Vacuolated lymphocytes (HP:0001922)4.94609093
7Abnormality of macrophages (HP:0004311)4.60418903
8Increased cerebral lipofuscin (HP:0011813)4.55042315
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.12998511
10Gastrointestinal infarctions (HP:0005244)3.77443491
11Mediastinal lymphadenopathy (HP:0100721)3.66761673
12Glomerulonephritis (HP:0000099)3.64528446
13Dysostosis multiplex (HP:0000943)3.64095570
14Gingivitis (HP:0000230)3.56276775
15Amyloidosis (HP:0011034)3.49366479
16Myocardial infarction (HP:0001658)3.48941756
17Recurrent skin infections (HP:0001581)3.46894407
18Abnormality of liposaccharide metabolism (HP:0010968)3.35993994
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.35993994
20Abnormality of glycolipid metabolism (HP:0010969)3.35993994
21Axonal loss (HP:0003447)3.34957838
22Disinhibition (HP:0000734)3.32896886
23Peritonitis (HP:0002586)3.30674782
24Osteolytic defects of the phalanges of the hand (HP:0009771)3.23547898
25Osteolytic defects of the hand bones (HP:0009699)3.23547898
26Urinary glycosaminoglycan excretion (HP:0003541)3.21798886
27Mucopolysacchariduria (HP:0008155)3.21798886
28Prostate neoplasm (HP:0100787)3.21397879
29Obstructive lung disease (HP:0006536)3.18179465
30Chronic obstructive pulmonary disease (HP:0006510)3.18179465
31T lymphocytopenia (HP:0005403)3.16461098
32Elevated erythrocyte sedimentation rate (HP:0003565)3.15885171
33Periodontitis (HP:0000704)3.09653878
34Hematochezia (HP:0002573)3.08116831
35* Keratoconjunctivitis sicca (HP:0001097)3.06220300
36* Myositis (HP:0100614)3.06209381
37Recurrent fungal infections (HP:0002841)3.06057288
38Abnormality of polysaccharide metabolism (HP:0011012)3.04331511
39Abnormality of glycosaminoglycan metabolism (HP:0004371)3.04331511
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.04331511
41Cellulitis (HP:0100658)3.01294667
42Abnormality of T cell number (HP:0011839)3.01216244
43Spontaneous hematomas (HP:0007420)2.92602616
44Autoimmune thrombocytopenia (HP:0001973)2.87752651
45Chest pain (HP:0100749)2.87242032
46Osteomyelitis (HP:0002754)2.81819822
47Thick nail (HP:0001805)2.81253107
48* Hemoptysis (HP:0002105)2.79277313
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.78896017
50* Keratoconjunctivitis (HP:0001096)2.75864980
51Episodic fever (HP:0001954)2.75135962
52Interstitial pulmonary disease (HP:0006530)2.73843374
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.70020584
54Nephritis (HP:0000123)2.69910194
55* Orchitis (HP:0100796)2.60212347
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59684830
57* Encephalitis (HP:0002383)2.57399860
58Recurrent viral infections (HP:0004429)2.57039168
59Vascular tortuosity (HP:0004948)2.56892537
60Pustule (HP:0200039)2.52321123
61Increased IgE level (HP:0003212)2.51168344
62Cervical subluxation (HP:0003308)2.46995395
63Basal ganglia calcification (HP:0002135)2.44929191
64Agnosia (HP:0010524)2.44304517
65Facial diplegia (HP:0001349)2.41015571
66Recurrent pneumonia (HP:0006532)2.40106946
67Abnormality of the peritoneum (HP:0002585)2.35301592
68Abnormality of complement system (HP:0005339)2.34281363
69Arterial tortuosity (HP:0005116)2.34051909
70Cerebral aneurysm (HP:0004944)2.32196472
71Stomatitis (HP:0010280)2.30389568
72Petechiae (HP:0000967)2.30009702
73* Pulmonary embolism (HP:0002204)2.27465990
74Hepatosplenomegaly (HP:0001433)2.26821135
75Spondylolisthesis (HP:0003302)2.24995528
76* Arterial thrombosis (HP:0004420)2.23847145
77Aortic aneurysm (HP:0004942)2.22350804
78Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20684124
79Subacute progressive viral hepatitis (HP:0006572)2.20325653
80Complement deficiency (HP:0004431)2.18972811
81* Vasculitis (HP:0002633)2.17730465
82Recurrent cutaneous fungal infections (HP:0011370)2.17490636
83Chronic mucocutaneous candidiasis (HP:0002728)2.17490636
84Colitis (HP:0002583)2.17192683
85Urticaria (HP:0001025)2.15324044
86Albinism (HP:0001022)2.13240315
87Prolonged bleeding time (HP:0003010)2.11301240
88Loss of speech (HP:0002371)2.09599924
89Recurrent lower respiratory tract infections (HP:0002783)2.09491219
90Absent frontal sinuses (HP:0002688)2.09264644
91Joint hemorrhage (HP:0005261)2.08751018
92* Gangrene (HP:0100758)2.08214025
93Pathologic fracture (HP:0002756)2.07690385
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06003571
95Abnormality of T cells (HP:0002843)2.05943247
96Abnormality of the lumbar spine (HP:0100712)2.05636820
97* Meningitis (HP:0001287)2.04415080
98Sepsis (HP:0100806)2.01997949
99Abnormality of the prostate (HP:0008775)2.01167857
100Bone pain (HP:0002653)2.00900834
101Vertebral compression fractures (HP:0002953)2.00605146
102J-shaped sella turcica (HP:0002680)2.00120772
103Granulocytopenia (HP:0001913)1.99306628
104Increased IgM level (HP:0003496)1.98530217
105Gingival bleeding (HP:0000225)1.98145106
106Inflammation of the large intestine (HP:0002037)1.98106734
107Chronic otitis media (HP:0000389)1.98067555
108* Anorexia (HP:0002039)1.97552594
109Gastrointestinal inflammation (HP:0004386)1.95828249
110Slow saccadic eye movements (HP:0000514)1.95603722
111Aortic dissection (HP:0002647)1.94964910
112Premature loss of primary teeth (HP:0006323)1.94485629
113Viral hepatitis (HP:0006562)1.94066619
114Epistaxis (HP:0000421)1.92579929
115Polycythemia (HP:0001901)1.92571655
116Eosinophilia (HP:0001880)1.92554266
117* Vertigo (HP:0002321)1.92310613
118Impaired platelet aggregation (HP:0003540)1.92039503
119Abnormal platelet function (HP:0011869)1.92039503
120Thrombocytosis (HP:0001894)1.90883299
121* Abnormality of the endocardium (HP:0004306)1.90862830
122* Abnormality of the pleura (HP:0002103)1.89278321
123Increased CSF protein (HP:0002922)1.88649024
124* Retrobulbar optic neuritis (HP:0100654)1.87378025
125* Optic neuritis (HP:0100653)1.87378025
126* Glomerulopathy (HP:0100820)1.86722472
127Increased serum ferritin (HP:0003281)1.86161281
128Hypergammaglobulinemia (HP:0010702)1.85949004
129Amaurosis fugax (HP:0100576)1.85887503
130Leukocytosis (HP:0001974)1.84013780
131* Pulmonary infiltrates (HP:0002113)1.83793794
132Tetraparesis (HP:0002273)1.82502508
133Upper motor neuron abnormality (HP:0002127)1.82156552
134* Polyneuropathy (HP:0001271)1.79949541
135Esophageal varix (HP:0002040)1.79787865
136Neurofibrillary tangles (HP:0002185)1.78763409
137Cheilitis (HP:0100825)1.78465504
138Skin ulcer (HP:0200042)1.77414605
139Asymmetric septal hypertrophy (HP:0001670)1.76505703
140Purpura (HP:0000979)1.75002169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.61282941
2BLK3.54311824
3MAP3K143.31395363
4RIPK43.25031757
5IRAK43.02371448
6KIT2.69901391
7TBK12.68767761
8ERN12.40303415
9TYK22.32329487
10PRPF4B2.25324804
11IRAK32.22353586
12MAP4K12.17322714
13NEK92.02589483
14TEC1.90172101
15IKBKB1.89380644
16CSF1R1.86461891
17IKBKE1.85917486
18JAK31.85244954
19TIE11.83499973
20JAK11.75798963
21TXK1.75090643
22TTN1.68981373
23ZAP701.66763437
24IRAK11.66397128
25BTK1.66360374
26IRAK21.55601847
27TRPM71.51270816
28CAMK1D1.47926349
29HCK1.45157304
30KSR21.42156948
31MAP3K11.40029724
32CSK1.39553433
33GRK61.37961515
34PIM21.35718495
35EPHB11.34133677
36GRK71.29947261
37MAP3K21.29659921
38SYK1.26169884
39TAOK11.26053816
40TAOK31.22630571
41STK101.22556488
42LYN1.19845643
43MAP3K111.16550847
44FGFR31.13775703
45MAP3K61.13688343
46FRK1.13591723
47PAK41.13043610
48TNK21.08994784
49CHUK1.08951778
50RIPK11.05514677
51PBK1.04779706
52MARK31.02255028
53TRIB30.99237106
54ZAK0.99158071
55LCK0.98124057
56PIK3CG0.98040239
57MATK0.96240247
58CDK60.95901720
59MAP2K30.95347542
60YES10.93125133
61PKN20.92157531
62MAP3K130.91933617
63LRRK20.91699277
64BMX0.90585037
65ITK0.89880719
66CAMKK20.89731878
67NME20.89596394
68STK30.89556011
69TAOK20.88226464
70PTK60.87841000
71ERBB30.86781343
72NUAK10.84119327
73EPHA30.84019310
74FES0.83662707
75MST1R0.82797855
76JAK20.82708873
77MARK20.81589605
78PDK10.80765001
79EIF2AK20.78759622
80ABL10.78668974
81PDPK10.77512418
82MAP3K50.76924714
83CAMK1G0.76761509
84FGR0.76634595
85CDC42BPA0.75911316
86PIM10.74973180
87MAP3K30.73914777
88PDK20.72538738
89MAP3K120.72254015
90KSR10.72196489
91CLK10.69673965
92EGFR0.68458210
93ACVR1B0.67859387
94RPS6KA40.64321642
95STK40.63438303
96SGK20.63193918
97RAF10.62782365
98PRKCD0.62568282
99ADRBK20.60927419
100BMPR20.60866969
101MAPK70.60183778
102SCYL20.59228082
103MAP2K40.59152447
104FGFR40.58983400
105SIK30.58528918
106MOS0.56510713
107PDGFRB0.55210991
108IGF1R0.54071271
109ABL20.53509054
110NLK0.53179723
111WNK10.52710265
112PTK2B0.51637387
113MST40.50186556
114TGFBR10.50085421
115RET0.47244830
116STK240.46765060
117MYLK0.46130913
118SIK10.45182969
119MAPKAPK20.42249574
120FLT30.41960477
121RPS6KA60.40053323
122PRKD20.39697169
123DAPK20.37682677
124SIK20.37316131
125HIPK20.35837619
126STK110.35457190
127DYRK1B0.35084188
128FYN0.35016442
129SGK30.34312483
130MAP2K60.33780593
131MAPK120.33018460
132INSR0.31229477
133PRKCQ0.30608452
134RPS6KC10.30516403
135RPS6KL10.30516403

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.68336289
2* Leishmaniasis_Homo sapiens_hsa051403.11916512
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.83166601
4Lysosome_Homo sapiens_hsa041422.65490840
5Osteoclast differentiation_Homo sapiens_hsa043802.56953724
6* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.53390476
7Other glycan degradation_Homo sapiens_hsa005112.52822363
8* Pertussis_Homo sapiens_hsa051332.29479107
9* Legionellosis_Homo sapiens_hsa051342.28845484
10* Tuberculosis_Homo sapiens_hsa051522.27816905
11Graft-versus-host disease_Homo sapiens_hsa053322.13222168
12* NF-kappa B signaling pathway_Homo sapiens_hsa040642.12076945
13* Malaria_Homo sapiens_hsa051442.11445393
14* Rheumatoid arthritis_Homo sapiens_hsa053232.06923860
15* Phagosome_Homo sapiens_hsa041451.99977610
16* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83175774
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82046252
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77098860
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74216511
20* Measles_Homo sapiens_hsa051621.73812326
21B cell receptor signaling pathway_Homo sapiens_hsa046621.69732003
22Hematopoietic cell lineage_Homo sapiens_hsa046401.68830732
23* Salmonella infection_Homo sapiens_hsa051321.66007744
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.51746167
25* Toxoplasmosis_Homo sapiens_hsa051451.49062983
26Allograft rejection_Homo sapiens_hsa053301.48828697
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48053904
28* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45148106
29TNF signaling pathway_Homo sapiens_hsa046681.44560480
30Antigen processing and presentation_Homo sapiens_hsa046121.43227522
31* Influenza A_Homo sapiens_hsa051641.42925161
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39901269
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.34317091
34Asthma_Homo sapiens_hsa053101.32532702
35Apoptosis_Homo sapiens_hsa042101.30974733
36Complement and coagulation cascades_Homo sapiens_hsa046101.26088174
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24674071
38Caffeine metabolism_Homo sapiens_hsa002321.23958878
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21794335
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.19590422
41Shigellosis_Homo sapiens_hsa051311.18913547
42Chemokine signaling pathway_Homo sapiens_hsa040621.17586970
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16121473
44Viral myocarditis_Homo sapiens_hsa054161.15112390
45* Amoebiasis_Homo sapiens_hsa051461.12805436
46Herpes simplex infection_Homo sapiens_hsa051681.12087002
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10904114
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10528049
49Non-small cell lung cancer_Homo sapiens_hsa052231.08071681
50African trypanosomiasis_Homo sapiens_hsa051431.04150510
51* Hepatitis B_Homo sapiens_hsa051611.00085052
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97066144
53Platelet activation_Homo sapiens_hsa046110.96403034
54* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95814237
55Type I diabetes mellitus_Homo sapiens_hsa049400.95326094
56Renal cell carcinoma_Homo sapiens_hsa052110.91841661
57Dorso-ventral axis formation_Homo sapiens_hsa043200.89527788
58Hepatitis C_Homo sapiens_hsa051600.89187596
59VEGF signaling pathway_Homo sapiens_hsa043700.88905230
60Chronic myeloid leukemia_Homo sapiens_hsa052200.86283595
61Pancreatic cancer_Homo sapiens_hsa052120.81913936
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81694204
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81408179
64FoxO signaling pathway_Homo sapiens_hsa040680.72462622
65Small cell lung cancer_Homo sapiens_hsa052220.69676182
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68320658
67Sphingolipid metabolism_Homo sapiens_hsa006000.67933846
68Prion diseases_Homo sapiens_hsa050200.66132504
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.65566487
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64777048
71Primary immunodeficiency_Homo sapiens_hsa053400.64734069
72Autoimmune thyroid disease_Homo sapiens_hsa053200.64634043
73GnRH signaling pathway_Homo sapiens_hsa049120.64185847
74Focal adhesion_Homo sapiens_hsa045100.64169615
75ECM-receptor interaction_Homo sapiens_hsa045120.63932754
76Notch signaling pathway_Homo sapiens_hsa043300.62287094
77Endometrial cancer_Homo sapiens_hsa052130.61436884
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60958596
79* Proteoglycans in cancer_Homo sapiens_hsa052050.60283533
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59906418
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59638887
82Renin-angiotensin system_Homo sapiens_hsa046140.57498245
83Acute myeloid leukemia_Homo sapiens_hsa052210.56752927
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55493735
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55058838
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52904648
87Type II diabetes mellitus_Homo sapiens_hsa049300.52507161
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52244687
89Adherens junction_Homo sapiens_hsa045200.52157450
90mTOR signaling pathway_Homo sapiens_hsa041500.51255911
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.49871885
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49773984
93Endocytosis_Homo sapiens_hsa041440.46415572
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45795153
95Choline metabolism in cancer_Homo sapiens_hsa052310.45571104
96Bladder cancer_Homo sapiens_hsa052190.45541003
97T cell receptor signaling pathway_Homo sapiens_hsa046600.44474672
98ErbB signaling pathway_Homo sapiens_hsa040120.43741191
99Inositol phosphate metabolism_Homo sapiens_hsa005620.43312912
100Prostate cancer_Homo sapiens_hsa052150.42690746
101MAPK signaling pathway_Homo sapiens_hsa040100.42674791
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41963715
103Glioma_Homo sapiens_hsa052140.41379740
104Arachidonic acid metabolism_Homo sapiens_hsa005900.41144037
105Rap1 signaling pathway_Homo sapiens_hsa040150.41141460
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40979586
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40845502
108Collecting duct acid secretion_Homo sapiens_hsa049660.39698813
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.38608133
110* HIF-1 signaling pathway_Homo sapiens_hsa040660.38590879
111Prolactin signaling pathway_Homo sapiens_hsa049170.38534859
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.37258285
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34878460
114Viral carcinogenesis_Homo sapiens_hsa052030.34869902
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34478580
116Galactose metabolism_Homo sapiens_hsa000520.31813915
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29593111
118Mineral absorption_Homo sapiens_hsa049780.29524791
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28086295
120Epstein-Barr virus infection_Homo sapiens_hsa051690.27737709
121Insulin resistance_Homo sapiens_hsa049310.26949990
122Melanoma_Homo sapiens_hsa052180.26000701
123MicroRNAs in cancer_Homo sapiens_hsa052060.25716165
124HTLV-I infection_Homo sapiens_hsa051660.23974399
125* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22009555

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