TLR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.86228123
2L-phenylalanine catabolic process (GO:0006559)6.19789210
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.19789210
4L-phenylalanine metabolic process (GO:0006558)5.82948613
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82948613
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75945545
7aromatic amino acid family catabolic process (GO:0009074)5.50856620
8leukocyte migration involved in inflammatory response (GO:0002523)5.47016901
9alpha-linolenic acid metabolic process (GO:0036109)5.34003112
10positive regulation by symbiont of host defense response (GO:0052509)5.28345754
11modulation by symbiont of host defense response (GO:0052031)5.28345754
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.28345754
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.28345754
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.28345754
15modulation by symbiont of host immune response (GO:0052553)5.28345754
16urea metabolic process (GO:0019627)5.25747349
17urea cycle (GO:0000050)5.25747349
18tryptophan catabolic process (GO:0006569)5.14441973
19indole-containing compound catabolic process (GO:0042436)5.14441973
20indolalkylamine catabolic process (GO:0046218)5.14441973
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11130314
22kynurenine metabolic process (GO:0070189)5.10132164
23positive regulation of gamma-delta T cell activation (GO:0046645)4.94869968
24neutrophil activation (GO:0042119)4.91879456
25bile acid biosynthetic process (GO:0006699)4.91177653
26tryptophan metabolic process (GO:0006568)4.90306682
27complement activation, alternative pathway (GO:0006957)4.83031647
28high-density lipoprotein particle remodeling (GO:0034375)4.82569115
29nitrogen cycle metabolic process (GO:0071941)4.81263824
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.78976906
31negative regulation of cell killing (GO:0031342)4.78976906
32negative regulation of fibrinolysis (GO:0051918)4.77939819
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75645875
34phospholipid efflux (GO:0033700)4.75194532
35positive regulation of mast cell activation (GO:0033005)4.71667053
36protein carboxylation (GO:0018214)4.65798128
37peptidyl-glutamic acid carboxylation (GO:0017187)4.65798128
38microglial cell activation (GO:0001774)4.65751228
39reverse cholesterol transport (GO:0043691)4.63830619
40regulation of protein activation cascade (GO:2000257)4.60946982
41sulfur amino acid catabolic process (GO:0000098)4.57914763
42regulation of fibrinolysis (GO:0051917)4.55833751
43regulation of triglyceride catabolic process (GO:0010896)4.48584588
44glyoxylate metabolic process (GO:0046487)4.45430898
45plasma lipoprotein particle clearance (GO:0034381)4.40596918
46macrophage activation involved in immune response (GO:0002281)4.38161227
47regulation of complement activation (GO:0030449)4.36882340
48granulocyte activation (GO:0036230)4.36473543
49regulation of cholesterol esterification (GO:0010872)4.32210646
50detection of other organism (GO:0098543)4.28177227
51plasma lipoprotein particle remodeling (GO:0034369)4.21736428
52protein-lipid complex remodeling (GO:0034368)4.21736428
53macromolecular complex remodeling (GO:0034367)4.21736428
54bile acid metabolic process (GO:0008206)4.20434085
55phospholipid homeostasis (GO:0055091)4.17642539
56detection of molecule of bacterial origin (GO:0032490)4.13684905
57cellular extravasation (GO:0045123)4.12036144
58regulation of B cell receptor signaling pathway (GO:0050855)4.11578229
59cholesterol efflux (GO:0033344)4.08375464
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.08112248
61homocysteine metabolic process (GO:0050667)4.04859293
62immunoglobulin mediated immune response (GO:0016064)4.04416419
63cysteine metabolic process (GO:0006534)4.04142077
64negative regulation of cholesterol transport (GO:0032375)4.02102690
65negative regulation of sterol transport (GO:0032372)4.02102690
66response to peptidoglycan (GO:0032494)4.00095729
67regulation of mast cell activation (GO:0033003)3.98622228
68detection of bacterium (GO:0016045)3.97140594
69tyrosine metabolic process (GO:0006570)3.96333807
70myeloid cell activation involved in immune response (GO:0002275)3.96211427
71amino-acid betaine metabolic process (GO:0006577)3.94472440
72response to host immune response (GO:0052572)3.91536705
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.91536705
74aromatic amino acid family metabolic process (GO:0009072)3.91324403
75acylglycerol homeostasis (GO:0055090)3.90671443
76triglyceride homeostasis (GO:0070328)3.90671443
77negative regulation of interleukin-12 production (GO:0032695)3.84244885
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.83695623
79detection of external biotic stimulus (GO:0098581)3.81918055
80serine family amino acid catabolic process (GO:0009071)3.81229997
81regulation of mast cell degranulation (GO:0043304)3.80979506
82bile acid and bile salt transport (GO:0015721)3.78424336
83regulation of platelet aggregation (GO:0090330)3.76670451
84antigen processing and presentation of endogenous antigen (GO:0019883)3.75428842
85low-density lipoprotein particle remodeling (GO:0034374)3.74936264
86positive regulation of mast cell degranulation (GO:0043306)3.71318945
87positive regulation of mast cell activation involved in immune response (GO:0033008)3.71318945
88fibrinolysis (GO:0042730)3.67570118
89lysine metabolic process (GO:0006553)3.66591781
90lysine catabolic process (GO:0006554)3.66591781
91regulation of mast cell activation involved in immune response (GO:0033006)3.65488358
92regulation of interferon-beta biosynthetic process (GO:0045357)3.65340507
93thrombin receptor signaling pathway (GO:0070493)3.65025015
94amine catabolic process (GO:0009310)3.63254673
95cellular biogenic amine catabolic process (GO:0042402)3.63254673
96plasma lipoprotein particle assembly (GO:0034377)3.63206406
97alpha-amino acid catabolic process (GO:1901606)3.62539007
98leukocyte degranulation (GO:0043299)3.60589108
99positive regulation of lipoprotein lipase activity (GO:0051006)3.59012784
100positive regulation of triglyceride lipase activity (GO:0061365)3.59012784
101positive regulation of lipid catabolic process (GO:0050996)3.58777251
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58422630
103imidazole-containing compound metabolic process (GO:0052803)3.58212144
104ethanol oxidation (GO:0006069)3.58131512
105G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.57890036
106negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.57855635
107negative regulation of T-helper cell differentiation (GO:0045623)3.57855635
108indolalkylamine metabolic process (GO:0006586)3.57697450
109cellular glucuronidation (GO:0052695)3.56625586
110regulation of gamma-delta T cell activation (GO:0046643)3.56004857
111B cell mediated immunity (GO:0019724)3.54707122
112negative regulation of lipase activity (GO:0060192)3.54103313
113response to host (GO:0075136)3.50206458
114response to host defenses (GO:0052200)3.50206458
115response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50206458
116negative regulation of lymphocyte mediated immunity (GO:0002707)3.49833841
117macrophage activation (GO:0042116)3.49429128
118benzene-containing compound metabolic process (GO:0042537)3.45050370
119leukocyte aggregation (GO:0070486)3.44354371
120detection of biotic stimulus (GO:0009595)3.44194068
121regulation of platelet activation (GO:0010543)3.42862244
122cellular modified amino acid catabolic process (GO:0042219)3.42143211
123complement activation (GO:0006956)3.41999045
124lipoprotein metabolic process (GO:0042157)3.40879284
125positive regulation of fatty acid beta-oxidation (GO:0032000)3.40595438
126complement activation, classical pathway (GO:0006958)3.39463146
127cholesterol homeostasis (GO:0042632)3.38977238
128regulation of myeloid leukocyte mediated immunity (GO:0002886)3.37338405
129plasma lipoprotein particle organization (GO:0071827)3.35740817
130dicarboxylic acid biosynthetic process (GO:0043650)3.35671888
131protein-lipid complex assembly (GO:0065005)3.35308139
132coenzyme catabolic process (GO:0009109)3.35056247
133sterol homeostasis (GO:0055092)3.34102385
134cellular amino acid catabolic process (GO:0009063)3.33518062
135antigen processing and presentation via MHC class Ib (GO:0002475)3.33432808
136positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.33260822
137arginine metabolic process (GO:0006525)3.33111593
138protein activation cascade (GO:0072376)3.32468657
139respiratory burst (GO:0045730)3.29909693
140regulation of cholesterol biosynthetic process (GO:0045540)3.29592388
141glutamate metabolic process (GO:0006536)3.28817034
142regulation of regulatory T cell differentiation (GO:0045589)3.24045296
143disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.24030891
144killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.24030891
145cellular ketone body metabolic process (GO:0046950)3.23678205
146positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.22183686
147regulation of cholesterol metabolic process (GO:0090181)3.21381111
148protein-lipid complex subunit organization (GO:0071825)3.21313796
149production of molecular mediator involved in inflammatory response (GO:0002532)3.19501579
150activated T cell proliferation (GO:0050798)3.19426794
151uronic acid metabolic process (GO:0006063)3.18994338
152glucuronate metabolic process (GO:0019585)3.18994338
153linoleic acid metabolic process (GO:0043651)3.17980783
154fatty acid oxidation (GO:0019395)3.17693593
155dendritic cell migration (GO:0036336)3.16638986
156dendritic cell chemotaxis (GO:0002407)3.16015818
157regulation of cholesterol homeostasis (GO:2000188)3.14818112
158lipid oxidation (GO:0034440)3.13888501
159positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12435814
160fatty acid beta-oxidation (GO:0006635)3.10967039
161drug catabolic process (GO:0042737)3.08842721
162blood coagulation, intrinsic pathway (GO:0007597)3.08523062
163acetyl-CoA metabolic process (GO:0006084)3.06472562
164carboxylic acid catabolic process (GO:0046395)3.06067768
165organic acid catabolic process (GO:0016054)3.06067768
166superoxide anion generation (GO:0042554)3.03543895
167positive regulation of cellular amide metabolic process (GO:0034250)3.03460074
168regulation of T-helper 2 cell differentiation (GO:0045628)3.02474548
169mast cell activation (GO:0045576)3.00700803
170regulation of leukocyte degranulation (GO:0043300)2.99615798
171negative regulation of leukocyte mediated immunity (GO:0002704)2.99150061
172regulation of memory T cell differentiation (GO:0043380)2.97725125
173positive regulation of B cell differentiation (GO:0045579)2.95541455
174negative regulation of T cell mediated immunity (GO:0002710)2.95091909
175neutrophil mediated immunity (GO:0002446)2.94561741
176regulation of MHC class II biosynthetic process (GO:0045346)2.91249186
177purinergic nucleotide receptor signaling pathway (GO:0035590)2.91174638
178antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90900976
179regulation of gamma-delta T cell differentiation (GO:0045586)2.89125776
180negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88383929
181negative regulation of alpha-beta T cell activation (GO:0046636)2.78250466
182positive regulation of type 2 immune response (GO:0002830)2.77239610
183myeloid leukocyte activation (GO:0002274)2.76603453
184adenosine receptor signaling pathway (GO:0001973)2.76371934
185interferon-gamma-mediated signaling pathway (GO:0060333)2.75973439
186positive regulation of B cell mediated immunity (GO:0002714)2.75757227
187positive regulation of immunoglobulin mediated immune response (GO:0002891)2.75757227
188tolerance induction (GO:0002507)2.75625978
189response to interleukin-15 (GO:0070672)2.75624001
190B cell receptor signaling pathway (GO:0050853)2.74993048
191regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74296047
192regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.74031460
193regulation of tolerance induction (GO:0002643)2.71975660
194G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.71055944
195negative regulation of interleukin-17 production (GO:0032700)2.70481909
196myeloid leukocyte mediated immunity (GO:0002444)2.70323918
197negative regulation of adaptive immune response (GO:0002820)2.69794795
198regulation of alpha-beta T cell proliferation (GO:0046640)2.67965854
199protein neddylation (GO:0045116)2.67423797
200regulation of interleukin-17 production (GO:0032660)2.66387230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.04136036
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.68581248
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.84514998
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.41329079
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.19360292
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.18327929
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.17860863
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.54475592
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.48344852
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66361518
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.62791754
12SPI1_23127762_ChIP-Seq_K562_Human2.51162394
13* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.49217024
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34890158
15LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.00029217
16CLOCK_20551151_ChIP-Seq_293T_Human1.99084132
17SPI1_23547873_ChIP-Seq_NB4_Human1.98327480
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.94195149
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92787376
20GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.90700472
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86459957
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82885560
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80344108
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77443429
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.74352380
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74343813
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73650524
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.73409617
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.73039312
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.72590551
31MYB_26560356_Chip-Seq_TH2_Human1.68440246
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65974725
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63948475
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.63591289
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62941852
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60177735
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60166336
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58971255
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58439444
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.58206447
41* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57708618
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57465162
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56403878
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55090855
45GATA1_22025678_ChIP-Seq_K562_Human1.54763924
46GATA3_26560356_Chip-Seq_TH2_Human1.51878524
47GATA3_27048872_Chip-Seq_THYMUS_Human1.51525447
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49135522
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46716662
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.46011454
51VDR_24763502_ChIP-Seq_THP-1_Human1.43806643
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42433424
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.42376986
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40111916
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35050824
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26299257
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24632566
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20306081
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20083406
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19551208
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18538510
62MYB_26560356_Chip-Seq_TH1_Human1.18410818
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17390044
64SMRT_27268052_Chip-Seq_Bcells_Human1.17008823
65MAF_26560356_Chip-Seq_TH1_Human1.14191189
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13442766
67UTX_26944678_Chip-Seq_JUKART_Human1.11289706
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.10382815
69* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10147635
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.08929770
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08816384
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08322041
73GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07902763
74* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07122121
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05561582
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01882868
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.01711769
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01096715
79EZH2_22144423_ChIP-Seq_EOC_Human0.98403791
80GBX2_23144817_ChIP-Seq_PC3_Human0.97822222
81EGR1_19032775_ChIP-ChIP_M12_Human0.97120244
82SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96997985
83SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95398992
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94439108
85ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94032301
86GATA4_25053715_ChIP-Seq_YYC3_Human0.93332952
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93112689
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92262192
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92167752
90VDR_24787735_ChIP-Seq_THP-1_Human0.90403889
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88244111
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87719911
93SOX2_20726797_ChIP-Seq_SW620_Human0.87549459
94SPI1_20517297_ChIP-Seq_HL60_Human0.86663110
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86356706
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86172134
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86073023
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85925828
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85925828
100BCAT_22108803_ChIP-Seq_LS180_Human0.85479337
101STAT1_20625510_ChIP-Seq_HELA_Human0.84953024
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.84084046
103GATA2_19941826_ChIP-Seq_K562_Human0.82758286
104GATA1_19941826_ChIP-Seq_K562_Human0.82647997
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.82624356
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82318035
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82085580
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.81504243
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80552189
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80430266
111TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79691543
112* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78695521
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78493418
114SALL4_22934838_ChIP-ChIP_CD34+_Human0.78368956
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77057915
116ER_23166858_ChIP-Seq_MCF-7_Human0.76814067
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75933168
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.75749972
119OCT1_27270436_Chip-Seq_PROSTATE_Human0.75557537
120RUNX_20019798_ChIP-Seq_JUKART_Human0.75313529
121TP63_17297297_ChIP-ChIP_HaCaT_Human0.75242882
122GATA3_21878914_ChIP-Seq_MCF-7_Human0.72671656
123* GATA3_26560356_Chip-Seq_TH1_Human0.72646620
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.72509870
125CJUN_26792858_Chip-Seq_BT549_Human0.72364302
126TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.72314731
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71655893
128HTT_18923047_ChIP-ChIP_STHdh_Human0.71242702
129VDR_22108803_ChIP-Seq_LS180_Human0.70539045
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.69899401
131* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.68838200
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.68812877
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.68523481
134* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.68207585
135NANOG_20526341_ChIP-Seq_ESCs_Human0.68197859
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68139316
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68062105
138LXR_22292898_ChIP-Seq_THP-1_Human0.67615467
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67594068
140STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.66352400
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66348370
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66277378
143SCL_19346495_ChIP-Seq_HPC-7_Human0.64221644
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.63926582
145MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.63802448
146PU_27001747_Chip-Seq_BMDM_Mouse0.62628838
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.62597314
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61235999
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.59884517
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.59545392
151GATA6_25053715_ChIP-Seq_YYC3_Human0.59256737
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58999112
153WT1_19549856_ChIP-ChIP_CCG9911_Human0.58905550
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58061561
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57718136
156* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.57386099
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57132562
158BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56638631
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.56638460
160SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.56635544
161CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.56045262
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.55787795
163CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.55199343
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.55108989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.99501807
2MP0005360_urolithiasis5.71438176
3MP0005085_abnormal_gallbladder_physiolo5.25301982
4MP0005365_abnormal_bile_salt5.07514977
5MP0008875_abnormal_xenobiotic_pharmacok4.32530941
6MP0009840_abnormal_foam_cell3.89484984
7MP0003252_abnormal_bile_duct3.70339377
8MP0010329_abnormal_lipoprotein_level3.20173393
9MP0003191_abnormal_cellular_cholesterol3.02480777
10MP0008004_abnormal_stomach_pH2.94629087
11* MP0005671_abnormal_response_to2.91636819
12MP0000685_abnormal_immune_system2.70496687
13MP0001800_abnormal_humoral_immune2.63772842
14MP0003806_abnormal_nucleotide_metabolis2.62840530
15MP0002138_abnormal_hepatobiliary_system2.62097442
16MP0001790_abnormal_immune_system2.50251082
17MP0005387_immune_system_phenotype2.50251082
18* MP0002723_abnormal_immune_serum2.42660069
19* MP0002452_abnormal_antigen_presenting2.30566097
20MP0005083_abnormal_biliary_tract2.25744967
21* MP0002420_abnormal_adaptive_immunity2.20179232
22* MP0001819_abnormal_immune_cell2.18173417
23MP0005332_abnormal_amino_acid2.13112524
24MP0003828_pulmonary_edema2.12932425
25MP0001666_abnormal_nutrient_absorption2.12345369
26* MP0000609_abnormal_liver_physiology2.07362354
27MP0004019_abnormal_vitamin_homeostasis2.01216106
28MP0003436_decreased_susceptibility_to2.01146442
29* MP0002118_abnormal_lipid_homeostasis1.94292180
30MP0002132_abnormal_respiratory_system1.83192488
31MP0009697_abnormal_copulation1.82174956
32MP0002398_abnormal_bone_marrow1.74607954
33* MP0010155_abnormal_intestine_physiology1.72083700
34MP0005451_abnormal_body_composition1.68152830
35MP0003705_abnormal_hypodermis_morpholog1.67362516
36MP0009764_decreased_sensitivity_to1.65310133
37MP0003195_calcinosis1.64296299
38MP0005670_abnormal_white_adipose1.63663902
39* MP0000716_abnormal_immune_system1.63493508
40MP0005319_abnormal_enzyme/_coenzyme1.62483740
41MP0003866_abnormal_defecation1.60527562
42MP0002277_abnormal_respiratory_mucosa1.60014755
43MP0004510_myositis1.60014304
44MP0003011_delayed_dark_adaptation1.57843877
45MP0002254_reproductive_system_inflammat1.57546261
46MP0005167_abnormal_blood-brain_barrier1.57331486
47MP0003763_abnormal_thymus_physiology1.51014251
48MP0000689_abnormal_spleen_morphology1.44635340
49MP0003183_abnormal_peptide_metabolism1.43945325
50* MP0002405_respiratory_system_inflammati1.41691664
51MP0003172_abnormal_lysosome_physiology1.40625099
52MP0003868_abnormal_feces_composition1.38012648
53MP0001851_eye_inflammation1.35928851
54MP0003303_peritoneal_inflammation1.35025852
55MP0003300_gastrointestinal_ulcer1.33410508
56* MP0002429_abnormal_blood_cell1.32024893
57MP0000604_amyloidosis1.31953032
58MP0000858_altered_metastatic_potential1.31442103
59MP0008260_abnormal_autophagy1.30458130
60MP0005058_abnormal_lysosome_morphology1.29851333
61MP0002722_abnormal_immune_system1.29845317
62MP0005584_abnormal_enzyme/coenzyme_acti1.28596078
63MP0005397_hematopoietic_system_phenotyp1.26366074
64MP0001545_abnormal_hematopoietic_system1.26366074
65MP0005464_abnormal_platelet_physiology1.26315219
66MP0000343_altered_response_to1.23747043
67MP0009333_abnormal_splenocyte_physiolog1.19604155
68MP0009278_abnormal_bone_marrow1.19415756
69MP0010368_abnormal_lymphatic_system1.18688546
70MP0002998_abnormal_bone_remodeling1.18620543
71MP0004381_abnormal_hair_follicle1.17545321
72MP0001835_abnormal_antigen_presentation1.16977857
73MP0001764_abnormal_homeostasis1.15996616
74MP0001986_abnormal_taste_sensitivity1.14892539
75MP0003724_increased_susceptibility_to1.13938625
76MP0003690_abnormal_glial_cell1.13819219
77MP0008469_abnormal_protein_level1.13173095
78MP0009763_increased_sensitivity_to1.11240444
79MP0005310_abnormal_salivary_gland1.10892857
80MP0001533_abnormal_skeleton_physiology1.09504544
81* MP0002419_abnormal_innate_immunity1.08776345
82MP0000569_abnormal_digit_pigmentation1.06260885
83MP0009643_abnormal_urine_homeostasis1.05683699
84MP0000598_abnormal_liver_morphology1.05295139
85MP0003656_abnormal_erythrocyte_physiolo1.03214282
86MP0003075_altered_response_to1.00050267
87MP0003186_abnormal_redox_activity0.99362019
88MP0000703_abnormal_thymus_morphology0.98706775
89MP0000015_abnormal_ear_pigmentation0.98619279
90MP0001853_heart_inflammation0.98050299
91MP0003045_fibrosis0.94498475
92MP0002971_abnormal_brown_adipose0.94437767
93MP0002653_abnormal_ependyma_morphology0.93773031
94MP0005647_abnormal_sex_gland0.91538383
95* MP0001663_abnormal_digestive_system0.91316717
96MP0004484_altered_response_of0.88623338
97MP0004782_abnormal_surfactant_physiolog0.88342259
98MP0010234_abnormal_vibrissa_follicle0.87647632
99MP0002928_abnormal_bile_duct0.86343996
100MP0005174_abnormal_tail_pigmentation0.84499434
101* MP0005334_abnormal_fat_pad0.82470679
102MP0002148_abnormal_hypersensitivity_rea0.81021319
103MP0005164_abnormal_response_to0.80697388
104MP0000249_abnormal_blood_vessel0.80668896
105MP0008438_abnormal_cutaneous_collagen0.80496796
106MP0004130_abnormal_muscle_cell0.79738560
107MP0005408_hypopigmentation0.78911397
108* MP0009642_abnormal_blood_homeostasis0.78443602
109MP0005390_skeleton_phenotype0.76837706
110* MP0001845_abnormal_inflammatory_respons0.76443587
111MP0002166_altered_tumor_susceptibility0.76395766
112MP0002837_dystrophic_cardiac_calcinosis0.76235696
113MP0005023_abnormal_wound_healing0.74965035
114MP0004883_abnormal_blood_vessel0.74236729
115* MP0000230_abnormal_systemic_arterial0.74165747
116MP0006082_CNS_inflammation0.73228218
117MP0009765_abnormal_xenobiotic_induced0.72686811
118* MP0005025_abnormal_response_to0.72391667
119MP0009053_abnormal_anal_canal0.70584858
120MP0001881_abnormal_mammary_gland0.69824785
121MP0003448_altered_tumor_morphology0.69543004
122MP0001765_abnormal_ion_homeostasis0.68796748
123MP0005084_abnormal_gallbladder_morpholo0.68655024
124MP0003279_aneurysm0.68336289
125MP0005376_homeostasis/metabolism_phenot0.68238892
126* MP0005666_abnormal_adipose_tissue0.67713056
127MP0003566_abnormal_cell_adhesion0.66195596
128MP0005166_decreased_susceptibility_to0.66034576
129MP0003787_abnormal_imprinting0.65926252
130MP0009785_altered_susceptibility_to0.65047239
131MP0005075_abnormal_melanosome_morpholog0.64478377
132MP0005535_abnormal_body_temperature0.64116843
133MP0003638_abnormal_response/metabolism_0.64081978
134MP0003453_abnormal_keratinocyte_physiol0.63921518
135MP0005410_abnormal_fertilization0.60902644
136MP0002796_impaired_skin_barrier0.60543030
137MP0002136_abnormal_kidney_physiology0.60169666
138MP0002060_abnormal_skin_morphology0.59473080
139MP0003795_abnormal_bone_structure0.59313619
140MP0003879_abnormal_hair_cell0.58363562
141MP0000465_gastrointestinal_hemorrhage0.57951770
142MP0005636_abnormal_mineral_homeostasis0.57037413
143MP0009384_cardiac_valve_regurgitation0.55947449
144MP0001968_abnormal_touch/_nociception0.55665586
145MP0005275_abnormal_skin_tensile0.55358585
146MP0005595_abnormal_vascular_smooth0.54826997
147MP0009115_abnormal_fat_cell0.54549880
148MP0005248_abnormal_Harderian_gland0.54315674
149MP0001756_abnormal_urination0.53356606
150MP0004947_skin_inflammation0.53345072
151MP0008874_decreased_physiological_sensi0.52646180
152MP0002295_abnormal_pulmonary_circulatio0.52281044
153* MP0005000_abnormal_immune_tolerance0.51523885
154MP0005220_abnormal_exocrine_pancreas0.50948383
155* MP0002693_abnormal_pancreas_physiology0.48708577
156MP0002133_abnormal_respiratory_system0.47994763
157MP0005388_respiratory_system_phenotype0.47994763

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.21534690
2Deep venous thrombosis (HP:0002625)6.57725315
3Intrahepatic cholestasis (HP:0001406)6.12826913
4Complement deficiency (HP:0004431)5.94950873
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.92007659
6Petechiae (HP:0000967)5.84912512
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.78321566
8Xanthomatosis (HP:0000991)5.75001158
9Prolonged partial thromboplastin time (HP:0003645)5.40482268
10Purpura (HP:0000979)5.25896977
11Hypobetalipoproteinemia (HP:0003563)5.22273507
12Abnormality of macrophages (HP:0004311)5.03786287
13Joint hemorrhage (HP:0005261)4.97516356
14Stomatitis (HP:0010280)4.80239484
15Systemic lupus erythematosus (HP:0002725)4.62581365
16Myositis (HP:0100614)4.60963283
17Abnormality of complement system (HP:0005339)4.50623229
18Optic neuritis (HP:0100653)4.42787408
19Retrobulbar optic neuritis (HP:0100654)4.42787408
20Hyperlipoproteinemia (HP:0010980)4.41373845
21Orchitis (HP:0100796)4.39044249
22Hypolipoproteinemia (HP:0010981)4.30005883
23Abnormality of the common coagulation pathway (HP:0010990)4.13827986
24Hypoalphalipoproteinemia (HP:0003233)4.10846716
25Epidermoid cyst (HP:0200040)4.02579236
26Elevated erythrocyte sedimentation rate (HP:0003565)4.01974243
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.90004569
28Myocardial infarction (HP:0001658)3.80409076
29Hyperammonemia (HP:0001987)3.70378038
30Glomerulonephritis (HP:0000099)3.68202633
31Abnormality of pyrimidine metabolism (HP:0004353)3.66141666
32Encephalitis (HP:0002383)3.60726076
33Recurrent gram-negative bacterial infections (HP:0005420)3.53951504
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.46614701
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.41573993
36Hypercholesterolemia (HP:0003124)3.40159059
37Fat malabsorption (HP:0002630)3.39678583
38Chronic obstructive pulmonary disease (HP:0006510)3.38177956
39Obstructive lung disease (HP:0006536)3.38177956
40Ketosis (HP:0001946)3.36156280
41Episodic fever (HP:0001954)3.34426721
42Conjugated hyperbilirubinemia (HP:0002908)3.32915633
43Abnormality of the intrinsic pathway (HP:0010989)3.30831233
44Recurrent fungal infections (HP:0002841)3.28658783
45Hyperglycinemia (HP:0002154)3.27270710
46Recurrent skin infections (HP:0001581)3.25831239
47Abnormality of methionine metabolism (HP:0010901)3.25727265
48Hyperglycinuria (HP:0003108)3.23611236
49Hypoglycemic coma (HP:0001325)3.18841549
50Keratoconjunctivitis sicca (HP:0001097)3.18245286
51Gastrointestinal infarctions (HP:0005244)3.18168794
52Abnormality of aspartate family amino acid metabolism (HP:0010899)3.13500174
53Abnormal platelet function (HP:0011869)3.11829515
54Impaired platelet aggregation (HP:0003540)3.11829515
55Abnormal delayed hypersensitivity skin test (HP:0002963)3.08098747
56Mediastinal lymphadenopathy (HP:0100721)3.07397994
57Chronic otitis media (HP:0000389)3.05225292
58Abnormality of serine family amino acid metabolism (HP:0010894)3.04685394
59Abnormality of glycine metabolism (HP:0010895)3.04685394
60Keratoconjunctivitis (HP:0001096)3.04070625
61Mitral stenosis (HP:0001718)3.02623148
62Meningitis (HP:0001287)3.02591093
63Vascular calcification (HP:0004934)2.98715155
64Arterial thrombosis (HP:0004420)2.94539546
65Hepatocellular carcinoma (HP:0001402)2.92498821
66Chronic mucocutaneous candidiasis (HP:0002728)2.90767182
67Recurrent cutaneous fungal infections (HP:0011370)2.90767182
68Vasculitis (HP:0002633)2.84742594
69Esophageal varix (HP:0002040)2.81889263
70Urticaria (HP:0001025)2.80761608
71Increased IgM level (HP:0003496)2.78391979
72Hypochromic microcytic anemia (HP:0004840)2.77233891
73Abnormality of nucleobase metabolism (HP:0010932)2.75900720
74Leukocytosis (HP:0001974)2.74003340
75Cardiovascular calcification (HP:0011915)2.73732889
76Abnormality of fatty-acid metabolism (HP:0004359)2.73208649
77Chest pain (HP:0100749)2.72551281
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.69826655
79Skin nodule (HP:0200036)2.66676519
80Abnormality of T cell number (HP:0011839)2.64727189
81Nephritis (HP:0000123)2.64202429
82T lymphocytopenia (HP:0005403)2.60968861
83Steatorrhea (HP:0002570)2.60288559
84Pulmonary infiltrates (HP:0002113)2.56540065
85Amyloidosis (HP:0011034)2.56338391
86Hyperbilirubinemia (HP:0002904)2.56191972
87Delayed CNS myelination (HP:0002188)2.51457264
88Gingival bleeding (HP:0000225)2.50183157
89Hemoptysis (HP:0002105)2.49317594
90Joint swelling (HP:0001386)2.48876981
91Spontaneous hematomas (HP:0007420)2.47506126
92Bruising susceptibility (HP:0000978)2.47375606
93Gingivitis (HP:0000230)2.47036518
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.46567003
95Absent/shortened dynein arms (HP:0200106)2.46567003
96Axonal loss (HP:0003447)2.35957594
97Menorrhagia (HP:0000132)2.35837969
98Increased cerebral lipofuscin (HP:0011813)2.34522297
99Anorexia (HP:0002039)2.33484471
100Vertigo (HP:0002321)2.31869828
101Abnormality of iron homeostasis (HP:0011031)2.31730272
102Abnormality of purine metabolism (HP:0004352)2.30780248
103Ketoacidosis (HP:0001993)2.29270877
104Abnormal respiratory motile cilium morphology (HP:0005938)2.26342165
105Abnormal respiratory epithelium morphology (HP:0012253)2.26342165
106Ventricular fibrillation (HP:0001663)2.23862896
107Abnormality of transition element cation homeostasis (HP:0011030)2.23048097
108Dyschromatopsia (HP:0007641)2.21576421
109Abnormal gallbladder physiology (HP:0012438)2.20910991
110Cholecystitis (HP:0001082)2.20910991
111Gangrene (HP:0100758)2.20737029
112Hemorrhage of the eye (HP:0011885)2.16741804
113Increased IgE level (HP:0003212)2.16672642
114Abnormal ciliary motility (HP:0012262)2.13565567
115Inflammation of the large intestine (HP:0002037)2.13014782
116Metabolic acidosis (HP:0001942)2.12316646
117Acanthocytosis (HP:0001927)2.12187478
118Panhypogammaglobulinemia (HP:0003139)2.11592909
119Abnormal gallbladder morphology (HP:0012437)2.11359917
120Hepatosplenomegaly (HP:0001433)2.11346678
121Abnormality of T cells (HP:0002843)2.11202321
122Cholelithiasis (HP:0001081)2.10895434
123Increased neuronal autofluorescent lipopigment (HP:0002074)2.10389308
124Hypochromic anemia (HP:0001931)2.07489093
125Abnormality of the heme biosynthetic pathway (HP:0010472)2.06360528
126Peritonitis (HP:0002586)2.06280877
127Eosinophilia (HP:0001880)2.03057386
128Hypertriglyceridemia (HP:0002155)2.02980275
129Autoimmune hemolytic anemia (HP:0001890)2.02909921
130Abnormality of serum amino acid levels (HP:0003112)2.01417041
131Osteomyelitis (HP:0002754)2.00860481
132Spontaneous abortion (HP:0005268)2.00690980
133Pancreatitis (HP:0001733)1.99226243
134Spastic diplegia (HP:0001264)1.99134368
135Chronic sinusitis (HP:0011109)1.98887361
136Decreased central vision (HP:0007663)1.98404587
137Recurrent bacterial skin infections (HP:0005406)1.96987944
138Granulocytopenia (HP:0001913)1.96749439
139Pulmonary embolism (HP:0002204)1.96211430
140Sensorimotor neuropathy (HP:0007141)1.95578685
141Upper motor neuron abnormality (HP:0002127)1.95560068
142Thrombophlebitis (HP:0004418)1.94690886
143Irritability (HP:0000737)1.94075365
144Hypoglycemic seizures (HP:0002173)1.94066711
145Retinal atrophy (HP:0001105)1.91674898
146Keratitis (HP:0000491)1.91438443
147Abnormality of proline metabolism (HP:0010907)1.90894114
148Hydroxyprolinuria (HP:0003080)1.90894114
149Increased serum ferritin (HP:0003281)1.90662092
150Recurrent viral infections (HP:0004429)1.90556597
151Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90368584
152Pustule (HP:0200039)1.90291894
153Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89987099
154Gastrointestinal inflammation (HP:0004386)1.88627130
155Polyneuropathy (HP:0001271)1.87828508
156Muscle fibrillation (HP:0010546)1.86982035
157Abnormality of the prostate (HP:0008775)1.86794702
158Recurrent sinusitis (HP:0011108)1.86442507
159Dicarboxylic aciduria (HP:0003215)1.86327465
160Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86327465
161Abnormality of the pleura (HP:0002103)1.81083025
162Malnutrition (HP:0004395)1.80568484
163Poikilocytosis (HP:0004447)1.79654902
164Abnormal enzyme/coenzyme activity (HP:0012379)1.78856047
165Amaurosis fugax (HP:0100576)1.78380836
166Abnormality of the endocardium (HP:0004306)1.77915872
167Recurrent abscess formation (HP:0002722)1.76845228
168Late onset (HP:0003584)1.76657074
169Stroke (HP:0001297)1.76239528
170Rickets (HP:0002748)1.76084649
171Lethargy (HP:0001254)1.75052701
172Neonatal onset (HP:0003623)1.74650023
173Epistaxis (HP:0000421)1.73446401
174Abnormal biliary tract physiology (HP:0012439)1.72202651
175Bile duct proliferation (HP:0001408)1.72202651
176Conjunctival telangiectasia (HP:0000524)1.72102958
177Eczematoid dermatitis (HP:0000976)1.71646381
178Abnormal platelet volume (HP:0011876)1.69622845
179Increased mean platelet volume (HP:0011877)1.68915142
180Right ventricular cardiomyopathy (HP:0011663)1.68757469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.49915001
2ERN13.88139580
3SIK13.30215189
4BCKDK3.04939131
5LMTK22.94898737
6TGFBR22.75182306
7FGFR42.69674236
8MAP3K142.64301923
9CAMK1D2.45874169
10IRAK32.42448142
11TAOK32.23549402
12TYK22.22846086
13SYK2.15537208
14PTK62.12543722
15EPHB12.10524017
16TXK2.09965476
17TRIB32.03296735
18TNK22.02211323
19FLT31.93184054
20MST41.91887287
21PKN21.91472331
22LATS11.84419887
23FRK1.79317914
24INSRR1.76792630
25CSK1.73785875
26PIK3CG1.73136682
27CAMK1G1.66064578
28ACVR1B1.56017707
29BMPR21.55165119
30NEK91.51663449
31IRAK11.49775658
32PTK2B1.49610742
33PTK21.47037501
34TBK11.46391057
35GRK11.45641953
36JAK11.38535126
37CSF1R1.32249761
38MAP3K111.27246104
39MET1.24336577
40MAP2K31.24096966
41ADRBK21.20529701
42ITK1.18459611
43YES11.18141451
44SIK31.17847725
45TAOK11.17817714
46LCK1.12274360
47PRKG21.11075769
48JAK21.10762492
49ERBB41.07785703
50PRKAA21.06605770
51ABL21.05738977
52MAPK151.02645703
53STK100.98224614
54MYLK0.96769941
55KDR0.94333231
56DAPK20.93498446
57MST1R0.93208355
58BMX0.92077119
59MARK30.91344559
60PDK10.90251242
61MATK0.89026942
62GRK60.88483587
63MAP3K20.88469080
64MAPK110.88243148
65NLK0.88131532
66TRPM70.86883885
67BTK0.85510534
68CDK60.84327804
69STK240.83366631
70FGR0.82866698
71CDK120.82851188
72FGFR30.80648366
73ADRBK10.80595135
74MAP2K40.80309145
75GRK50.80210562
76MAP3K120.78582348
77ZAP700.78090510
78BLK0.76677190
79MAP3K60.75608541
80RIPK10.74560097
81KIT0.74418751
82IKBKE0.74191968
83CHUK0.73252457
84MAP3K50.72855123
85EPHA30.72068524
86FGFR20.71434365
87GRK70.71138113
88GSK3A0.69168407
89MAPK120.67167015
90JAK30.66187741
91IRAK20.65527050
92MAPK40.65433154
93TEC0.65109122
94TTN0.64395542
95SGK20.63747987
96FYN0.63057873
97HCK0.62163450
98CAMKK20.62104502
99ERBB20.61950781
100OXSR10.61762956
101NTRK10.61462230
102MAP3K30.60236658
103IRAK40.59578078
104PAK40.57551344
105EGFR0.57538434
106MARK20.56587238
107IKBKB0.56578811
108MAP4K10.56538582
109SGK30.56384847
110RET0.53392635
111WNK30.53227509
112STK380.53150194
113PRKACG0.51157862
114IGF1R0.50823735
115MAP3K70.50589512
116STK30.49431383
117FER0.48328455
118PRKD20.47546876
119PDGFRA0.46909882
120PDGFRB0.45820924
121TLK10.45271952
122FES0.45205371
123NUAK10.44914012
124LYN0.44155847
125TESK20.42952327
126MAP2K20.42914925
127MOS0.42802609
128MAP3K130.42082156
129MAPK70.41991365
130STK110.41946656
131PINK10.41586941
132MAP2K10.40741137
133ABL10.40212153
134LRRK20.39981318
135PRKCH0.38390497
136PRKAA10.37876903
137PDPK10.37793254
138MAPK130.36411282
139TNIK0.36203203
140MAP2K60.35846020
141HIPK20.35574001
142MAP3K10.35276713
143TAOK20.35119270
144CDC42BPA0.34238925
145PRKCQ0.33659877
146CAMK10.33396076
147CDK190.33242990
148CAMK40.32092640
149CLK10.31200313

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32218780
2Nitrogen metabolism_Homo sapiens_hsa009103.26147549
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18161978
4Complement and coagulation cascades_Homo sapiens_hsa046103.09610220
5Arginine biosynthesis_Homo sapiens_hsa002202.99348055
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92400896
7Staphylococcus aureus infection_Homo sapiens_hsa051502.86484322
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73529947
9Platelet activation_Homo sapiens_hsa046112.68237301
10Tryptophan metabolism_Homo sapiens_hsa003802.58044169
11Fatty acid degradation_Homo sapiens_hsa000712.56885464
12Graft-versus-host disease_Homo sapiens_hsa053322.34690272
13Allograft rejection_Homo sapiens_hsa053302.29880468
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25417324
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18423654
16Autoimmune thyroid disease_Homo sapiens_hsa053202.14949966
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14653347
18Hematopoietic cell lineage_Homo sapiens_hsa046402.14098727
19Caffeine metabolism_Homo sapiens_hsa002322.12252530
20PPAR signaling pathway_Homo sapiens_hsa033202.10372537
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.03520571
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01172963
23Histidine metabolism_Homo sapiens_hsa003402.01015494
24Peroxisome_Homo sapiens_hsa041461.99323885
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94425998
26Fatty acid metabolism_Homo sapiens_hsa012121.89804031
27Chemical carcinogenesis_Homo sapiens_hsa052041.83626240
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83110435
29beta-Alanine metabolism_Homo sapiens_hsa004101.82781113
30Chemokine signaling pathway_Homo sapiens_hsa040621.82636727
31Butanoate metabolism_Homo sapiens_hsa006501.79817642
32* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79424623
33Propanoate metabolism_Homo sapiens_hsa006401.79411502
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78949601
35Asthma_Homo sapiens_hsa053101.78825406
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76166818
37Type I diabetes mellitus_Homo sapiens_hsa049401.71330843
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71040327
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.69121209
40Primary immunodeficiency_Homo sapiens_hsa053401.66951911
41ABC transporters_Homo sapiens_hsa020101.62258075
42Retinol metabolism_Homo sapiens_hsa008301.61744779
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.54599050
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53569456
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53251162
46T cell receptor signaling pathway_Homo sapiens_hsa046601.48988408
47Phenylalanine metabolism_Homo sapiens_hsa003601.43081838
48Bile secretion_Homo sapiens_hsa049761.40697808
49Selenocompound metabolism_Homo sapiens_hsa004501.39557038
50Starch and sucrose metabolism_Homo sapiens_hsa005001.35820631
51Antigen processing and presentation_Homo sapiens_hsa046121.34515759
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32907794
53Measles_Homo sapiens_hsa051621.32012221
54* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31136496
55Fatty acid elongation_Homo sapiens_hsa000621.27280455
56Tyrosine metabolism_Homo sapiens_hsa003501.26219556
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.26069355
58Rheumatoid arthritis_Homo sapiens_hsa053231.25779467
59Viral myocarditis_Homo sapiens_hsa054161.22983369
60Toxoplasmosis_Homo sapiens_hsa051451.21029578
61Sulfur metabolism_Homo sapiens_hsa009201.19270187
62Fat digestion and absorption_Homo sapiens_hsa049751.16829513
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14454157
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.13284311
65Arachidonic acid metabolism_Homo sapiens_hsa005901.08758595
66Influenza A_Homo sapiens_hsa051641.08248381
67Pyruvate metabolism_Homo sapiens_hsa006201.07208842
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06422089
69Collecting duct acid secretion_Homo sapiens_hsa049661.03957612
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02014795
71Steroid biosynthesis_Homo sapiens_hsa001000.94053995
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91609839
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89820013
74Shigellosis_Homo sapiens_hsa051310.88266846
75Fatty acid biosynthesis_Homo sapiens_hsa000610.87289035
76Carbon metabolism_Homo sapiens_hsa012000.87000986
77Biosynthesis of amino acids_Homo sapiens_hsa012300.86110159
78Arginine and proline metabolism_Homo sapiens_hsa003300.84741240
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84427274
80Lysine degradation_Homo sapiens_hsa003100.84259469
81Endocytosis_Homo sapiens_hsa041440.83210374
82Folate biosynthesis_Homo sapiens_hsa007900.82372826
83Acute myeloid leukemia_Homo sapiens_hsa052210.81675848
84Herpes simplex infection_Homo sapiens_hsa051680.81296835
85Glycerolipid metabolism_Homo sapiens_hsa005610.79839003
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.78899721
87African trypanosomiasis_Homo sapiens_hsa051430.78850282
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77733543
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.76031470
90Vitamin digestion and absorption_Homo sapiens_hsa049770.74956845
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74452493
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74329087
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73206482
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73130765
95Non-small cell lung cancer_Homo sapiens_hsa052230.72861880
96Dorso-ventral axis formation_Homo sapiens_hsa043200.72812584
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72447000
98Serotonergic synapse_Homo sapiens_hsa047260.70433441
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68009393
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65297406
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.65236497
102Choline metabolism in cancer_Homo sapiens_hsa052310.63152342
103Hepatitis B_Homo sapiens_hsa051610.62081959
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62078212
105Apoptosis_Homo sapiens_hsa042100.61675523
106Regulation of autophagy_Homo sapiens_hsa041400.60189543
107One carbon pool by folate_Homo sapiens_hsa006700.58662640
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58387886
109VEGF signaling pathway_Homo sapiens_hsa043700.57825004
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.55670967
111Pancreatic cancer_Homo sapiens_hsa052120.55083540
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55069137
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.54841118
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.54712896
115Long-term depression_Homo sapiens_hsa047300.53734174
116Vitamin B6 metabolism_Homo sapiens_hsa007500.52907933
117Olfactory transduction_Homo sapiens_hsa047400.51893629
118* Salmonella infection_Homo sapiens_hsa051320.51392513
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51277056
120Rap1 signaling pathway_Homo sapiens_hsa040150.50249918
121Renal cell carcinoma_Homo sapiens_hsa052110.50179227
122Sulfur relay system_Homo sapiens_hsa041220.48584004
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48081547
124FoxO signaling pathway_Homo sapiens_hsa040680.46591888
125Insulin resistance_Homo sapiens_hsa049310.46172604
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45816303
127Glutathione metabolism_Homo sapiens_hsa004800.45071924
128Systemic lupus erythematosus_Homo sapiens_hsa053220.44680289
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.44324769
130Prion diseases_Homo sapiens_hsa050200.43436335
131Ras signaling pathway_Homo sapiens_hsa040140.42684940
132Gap junction_Homo sapiens_hsa045400.42446015
133Morphine addiction_Homo sapiens_hsa050320.42414414
134Prolactin signaling pathway_Homo sapiens_hsa049170.42238016
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42154520
136Endometrial cancer_Homo sapiens_hsa052130.41736691
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.41384637
138Pancreatic secretion_Homo sapiens_hsa049720.40267789
139Lysosome_Homo sapiens_hsa041420.37172606
140MAPK signaling pathway_Homo sapiens_hsa040100.36128102
141Pentose phosphate pathway_Homo sapiens_hsa000300.34283505
142Galactose metabolism_Homo sapiens_hsa000520.28840254
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27670134
144Malaria_Homo sapiens_hsa051440.26246395
145Metabolic pathways_Homo sapiens_hsa011000.24245557
146Pertussis_Homo sapiens_hsa051330.22936651
147Leishmaniasis_Homo sapiens_hsa051400.19110181
148Amoebiasis_Homo sapiens_hsa051460.16848113
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.16526481
150Fructose and mannose metabolism_Homo sapiens_hsa000510.15995342
151Mineral absorption_Homo sapiens_hsa049780.15627453
152* Legionellosis_Homo sapiens_hsa051340.15407892
153AMPK signaling pathway_Homo sapiens_hsa041520.14825431
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.13553380
155Osteoclast differentiation_Homo sapiens_hsa043800.13373555
156Linoleic acid metabolism_Homo sapiens_hsa005910.13173264
157Glucagon signaling pathway_Homo sapiens_hsa049220.12408438
158Other glycan degradation_Homo sapiens_hsa005110.11132591
159* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.09347956
160Hepatitis C_Homo sapiens_hsa051600.06428775
161Tuberculosis_Homo sapiens_hsa051520.05643143
162Insulin signaling pathway_Homo sapiens_hsa049100.05553102
163Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.04154628
164Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02780158
165B cell receptor signaling pathway_Homo sapiens_hsa04662-5.9024334
166Phagosome_Homo sapiens_hsa04145-0.0217534
167Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142-0.0203489
168Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0153651
169Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0152654
170TNF signaling pathway_Homo sapiens_hsa04668-0.0150905

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