TLR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.18772088
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.96834088
3negative regulation of cell killing (GO:0031342)5.96834088
4* positive regulation by symbiont of host defense response (GO:0052509)5.91029881
5* modulation by symbiont of host defense response (GO:0052031)5.91029881
6* modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.91029881
7* modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.91029881
8* positive regulation by organism of defense response of other organism involved in symbiotic interact5.91029881
9* modulation by symbiont of host immune response (GO:0052553)5.91029881
10neutrophil activation involved in immune response (GO:0002283)5.13216710
11detection of other organism (GO:0098543)5.03182873
12regulation of interferon-beta biosynthetic process (GO:0045357)4.87318221
13response to peptidoglycan (GO:0032494)4.69874613
14immunoglobulin mediated immune response (GO:0016064)4.61620143
15* macrophage activation involved in immune response (GO:0002281)4.60884010
16* detection of external biotic stimulus (GO:0098581)4.59324061
17detection of bacterium (GO:0016045)4.49882910
18respiratory burst (GO:0045730)4.44648511
19positive regulation of gamma-delta T cell activation (GO:0046645)4.44447743
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44378990
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44378990
22antigen processing and presentation of endogenous antigen (GO:0019883)4.41290296
23positive regulation of chemokine biosynthetic process (GO:0045080)4.37026262
24positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.35035482
25positive regulation of interferon-alpha production (GO:0032727)4.27283615
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22797760
27regulation of B cell receptor signaling pathway (GO:0050855)4.17229429
28positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.15431676
29lipopolysaccharide-mediated signaling pathway (GO:0031663)4.14690312
30regulation of interferon-alpha production (GO:0032647)4.10947785
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.08976580
32response to interleukin-15 (GO:0070672)4.01958294
33* detection of biotic stimulus (GO:0009595)3.97285202
34leukocyte aggregation (GO:0070486)3.92498933
35granulocyte activation (GO:0036230)3.86545630
36negative regulation of interleukin-12 production (GO:0032695)3.86490191
37positive regulation of B cell differentiation (GO:0045579)3.81037354
38neutrophil activation (GO:0042119)3.76615482
39* response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.74103224
40* response to host immune response (GO:0052572)3.74103224
41negative regulation of T cell mediated immunity (GO:0002710)3.73530323
42regulation of chemokine biosynthetic process (GO:0045073)3.70719828
43cellular response to interleukin-15 (GO:0071350)3.70329513
44positive regulation of antigen processing and presentation (GO:0002579)3.63981562
45* myeloid cell activation involved in immune response (GO:0002275)3.60297523
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57655680
47cellular extravasation (GO:0045123)3.57298517
48negative regulation of leukocyte mediated immunity (GO:0002704)3.56572895
49regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.54803648
50regulation of mast cell degranulation (GO:0043304)3.54526092
51negative regulation of mast cell activation (GO:0033004)3.54331414
52* microglial cell activation (GO:0001774)3.50573756
53regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.50167881
54B cell mediated immunity (GO:0019724)3.48932540
55superoxide anion generation (GO:0042554)3.47598529
56positive regulation of heat generation (GO:0031652)3.42307621
57leukocyte migration involved in inflammatory response (GO:0002523)3.42051055
58positive regulation of macrophage differentiation (GO:0045651)3.41768751
59* response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.41029429
60* response to host (GO:0075136)3.41029429
61* response to host defenses (GO:0052200)3.41029429
62cellular response to type I interferon (GO:0071357)3.39607026
63type I interferon signaling pathway (GO:0060337)3.39607026
64response to type I interferon (GO:0034340)3.38881428
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.37973853
66hydrogen peroxide biosynthetic process (GO:0050665)3.37796609
67interferon-gamma-mediated signaling pathway (GO:0060333)3.35773646
68regulation of mast cell activation (GO:0033003)3.35012873
69regulation of mast cell activation involved in immune response (GO:0033006)3.34900902
70myeloid leukocyte mediated immunity (GO:0002444)3.34068607
71response to muramyl dipeptide (GO:0032495)3.33946909
72* macrophage activation (GO:0042116)3.30774708
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29867040
74production of molecular mediator involved in inflammatory response (GO:0002532)3.29335393
75negative thymic T cell selection (GO:0045060)3.28911254
76regulation of B cell differentiation (GO:0045577)3.28438851
77regulation of fever generation (GO:0031620)3.27870474
78T cell migration (GO:0072678)3.25217658
79regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23193347
80defense response to protozoan (GO:0042832)3.22568929
81negative T cell selection (GO:0043383)3.20570939
82positive regulation of mast cell activation (GO:0033005)3.20131496
83positive thymic T cell selection (GO:0045059)3.17186030
84* detection of molecule of bacterial origin (GO:0032490)3.14235657
85positive regulation of mast cell degranulation (GO:0043306)3.11855052
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.11855052
87dendritic cell migration (GO:0036336)3.11452391
88positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.09546978
89reactive oxygen species biosynthetic process (GO:1903409)3.08659213
90B cell receptor signaling pathway (GO:0050853)3.07425700
91cellular response to zinc ion (GO:0071294)3.06830334
92regulation of antigen processing and presentation (GO:0002577)3.05397483
93positive regulation of interferon-beta production (GO:0032728)3.02867998
94antigen processing and presentation via MHC class Ib (GO:0002475)3.02403204
95regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.01168065
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.99847227
97negative regulation of T-helper cell differentiation (GO:0045623)2.97544101
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97544101
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97479241
100positive regulation of cellular amide metabolic process (GO:0034250)2.97181054
101negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.96302289
102regulation of alpha-beta T cell proliferation (GO:0046640)2.95955509
103regulation of gamma-delta T cell activation (GO:0046643)2.95846356
104germinal center formation (GO:0002467)2.94622771
105response to protozoan (GO:0001562)2.93732802
106* myeloid leukocyte activation (GO:0002274)2.92079264
107regulation of interleukin-8 biosynthetic process (GO:0045414)2.91983900
108regulation of tolerance induction (GO:0002643)2.91246140
109positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90883915
110myeloid dendritic cell activation (GO:0001773)2.90632391
111dendritic cell chemotaxis (GO:0002407)2.90177544
112mast cell activation (GO:0045576)2.89092510
113regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88520117
114positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.88462923
115positive regulation of NF-kappaB import into nucleus (GO:0042346)2.87760080
116positive regulation of humoral immune response (GO:0002922)2.87675596
117lipopolysaccharide metabolic process (GO:0008653)2.87629251
118positive regulation of chemokine production (GO:0032722)2.86310587
119leukocyte cell-cell adhesion (GO:0007159)2.85916153
120neutrophil mediated immunity (GO:0002446)2.84458262
121positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.82657873
122negative regulation of phagocytosis (GO:0050765)2.82269216
123positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81986467
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80483274
125regulation of leukocyte degranulation (GO:0043300)2.80004397
126regulation of gamma-delta T cell differentiation (GO:0045586)2.79622592
127regulation of podosome assembly (GO:0071801)2.79480986
128* positive regulation of cytokine biosynthetic process (GO:0042108)2.78371114
129neutrophil chemotaxis (GO:0030593)2.77629350
130leukocyte degranulation (GO:0043299)2.76950505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.78010451
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.34464849
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.53190615
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17918617
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.16359389
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.99524469
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.80330913
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79705964
9* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72383557
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64268268
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.58702391
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58413388
13* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.13795230
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.09101155
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00931669
16SCL_19346495_ChIP-Seq_HPC-7_Human2.87313983
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77422738
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.60538253
19* SPI1_23547873_ChIP-Seq_NB4_Human2.50518516
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47336384
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45454577
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36525714
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26519522
24RUNX_20019798_ChIP-Seq_JUKART_Human2.14162054
25MYB_26560356_Chip-Seq_TH2_Human2.11350200
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02105996
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.00259182
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99952068
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99055608
30VDR_24763502_ChIP-Seq_THP-1_Human1.95577622
31MYB_26560356_Chip-Seq_TH1_Human1.85971545
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84621045
33MAF_26560356_Chip-Seq_TH1_Human1.84138299
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83015876
35SPI1_23127762_ChIP-Seq_K562_Human1.82238848
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79628783
37PU_27001747_Chip-Seq_BMDM_Mouse1.73697996
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73445965
39VDR_21846776_ChIP-Seq_THP-1_Human1.72536206
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68476359
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68364445
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66991217
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64639946
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.58922119
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57356353
46* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56175486
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53475562
48UTX_26944678_Chip-Seq_JUKART_Human1.46605509
49VDR_24787735_ChIP-Seq_THP-1_Human1.46604457
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42034255
51GATA3_27048872_Chip-Seq_THYMUS_Human1.39948719
52CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36483837
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36388634
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35006338
55MYC_22102868_ChIP-Seq_BL_Human1.34924475
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30854353
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30752421
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30576009
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28585208
60TCF7_22412390_ChIP-Seq_EML_Mouse1.26254004
61GATA3_26560356_Chip-Seq_TH2_Human1.24689435
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24258603
63KDM2B_26808549_Chip-Seq_DND41_Human1.22548394
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20631503
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17062495
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14118236
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13325477
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12923025
69GATA1_22025678_ChIP-Seq_K562_Human1.11289007
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.10859378
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09324591
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07013678
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05455322
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03327419
75MAF_26560356_Chip-Seq_TH2_Human1.01808836
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01752146
77FOXM1_23109430_ChIP-Seq_U2OS_Human0.97505111
78GATA1_19941827_ChIP-Seq_MEL_Mouse0.95258627
79SMRT_27268052_Chip-Seq_Bcells_Human0.94450266
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94097838
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93295231
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92007336
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91702483
84TFEB_21752829_ChIP-Seq_HELA_Human0.89821052
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89126368
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89114050
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86748715
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.86473173
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81605384
90GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80886535
91GATA2_19941826_ChIP-Seq_K562_Human0.80740741
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80679338
93GATA1_19941826_ChIP-Seq_K562_Human0.80563265
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80425757
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76857406
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.76800382
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76767127
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.76210803
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75137571
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74208194
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73403171
102SPI1_20517297_ChIP-Seq_HL60_Human0.71047834
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.70618159
104ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69376203
105NCOR1_26117541_ChIP-Seq_K562_Human0.68805120
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68765610
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.66265254
108BCL6_27268052_Chip-Seq_Bcells_Human0.65495419
109GATA3_26560356_Chip-Seq_TH1_Human0.62997911
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.60033553
111ELF1_17652178_ChIP-ChIP_JURKAT_Human0.58950537
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58166297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.43695004
2MP0009785_altered_susceptibility_to3.66267495
3MP0003436_decreased_susceptibility_to3.64175435
4* MP0002419_abnormal_innate_immunity3.25882437
5MP0003303_peritoneal_inflammation3.25356958
6MP0002148_abnormal_hypersensitivity_rea3.03684459
7MP0005000_abnormal_immune_tolerance3.03258057
8MP0003724_increased_susceptibility_to3.02583416
9MP0005025_abnormal_response_to2.99332394
10MP0005671_abnormal_response_to2.98328710
11MP0005058_abnormal_lysosome_morphology2.93007205
12MP0001790_abnormal_immune_system2.88622200
13MP0005387_immune_system_phenotype2.88622200
14MP0001800_abnormal_humoral_immune2.82061413
15* MP0002452_abnormal_antigen_presenting2.80746544
16MP0006082_CNS_inflammation2.78222440
17MP0000685_abnormal_immune_system2.71766187
18MP0005464_abnormal_platelet_physiology2.63494321
19* MP0002723_abnormal_immune_serum2.61638577
20MP0003172_abnormal_lysosome_physiology2.48044311
21* MP0001819_abnormal_immune_cell2.44474221
22* MP0002420_abnormal_adaptive_immunity2.43870268
23MP0005451_abnormal_body_composition2.27946703
24MP0008260_abnormal_autophagy2.24285021
25MP0001533_abnormal_skeleton_physiology2.07088561
26MP0002405_respiratory_system_inflammati2.05363676
27MP0004510_myositis2.02063481
28MP0001853_heart_inflammation1.99488980
29MP0001845_abnormal_inflammatory_respons1.98018628
30MP0003191_abnormal_cellular_cholesterol1.95687997
31MP0009764_decreased_sensitivity_to1.89710528
32MP0002398_abnormal_bone_marrow1.88539197
33MP0000716_abnormal_immune_system1.86494849
34MP0004947_skin_inflammation1.77710820
35MP0009278_abnormal_bone_marrow1.72560017
36MP0010155_abnormal_intestine_physiology1.70222316
37MP0000689_abnormal_spleen_morphology1.67459681
38MP0008469_abnormal_protein_level1.65833566
39MP0004381_abnormal_hair_follicle1.64589174
40MP0009840_abnormal_foam_cell1.61313477
41MP0000343_altered_response_to1.61094771
42MP0002396_abnormal_hematopoietic_system1.58262266
43MP0002429_abnormal_blood_cell1.55126982
44MP0009333_abnormal_splenocyte_physiolog1.54710192
45MP0002006_tumorigenesis1.54077733
46MP0002722_abnormal_immune_system1.51331185
47MP0003075_altered_response_to1.47766625
48MP0001545_abnormal_hematopoietic_system1.45811659
49MP0005397_hematopoietic_system_phenotyp1.45811659
50MP0003448_altered_tumor_morphology1.45696311
51MP0003183_abnormal_peptide_metabolism1.38861356
52MP0003763_abnormal_thymus_physiology1.34687723
53MP0002998_abnormal_bone_remodeling1.32236839
54MP0003300_gastrointestinal_ulcer1.31321257
55MP0002166_altered_tumor_susceptibility1.31208027
56MP0000858_altered_metastatic_potential1.30129486
57MP0005174_abnormal_tail_pigmentation1.22309989
58MP0002933_joint_inflammation1.18940863
59MP0005310_abnormal_salivary_gland1.18303955
60MP0005166_decreased_susceptibility_to1.17644742
61MP0004808_abnormal_hematopoietic_stem1.17225368
62MP0000569_abnormal_digit_pigmentation1.16108484
63MP0000465_gastrointestinal_hemorrhage1.07728402
64MP0002277_abnormal_respiratory_mucosa1.06096988
65MP0005390_skeleton_phenotype0.99063142
66MP0008057_abnormal_DNA_replication0.98944943
67MP0003186_abnormal_redox_activity0.98486152
68MP0004782_abnormal_surfactant_physiolog0.97799119
69MP0009763_increased_sensitivity_to0.97400559
70MP0005167_abnormal_blood-brain_barrier0.97373291
71MP0003828_pulmonary_edema0.93968289
72MP0010307_abnormal_tumor_latency0.92870718
73MP0000015_abnormal_ear_pigmentation0.91242947
74MP0005164_abnormal_response_to0.91153529
75MP0001851_eye_inflammation0.90798904
76MP0003221_abnormal_cardiomyocyte_apopto0.90688691
77MP0000703_abnormal_thymus_morphology0.89949983
78MP0000604_amyloidosis0.89850530
79MP0000249_abnormal_blood_vessel0.87328213
80MP0003690_abnormal_glial_cell0.83923307
81MP0001873_stomach_inflammation0.82929368
82MP0003656_abnormal_erythrocyte_physiolo0.82049148
83MP0006054_spinal_hemorrhage0.78888956
84MP0001663_abnormal_digestive_system0.73559682
85MP0000371_diluted_coat_color0.72733063
86MP0002332_abnormal_exercise_endurance0.71993975
87MP0003795_abnormal_bone_structure0.71938627
88MP0004130_abnormal_muscle_cell0.70922916
89MP0003045_fibrosis0.70503153
90MP0003279_aneurysm0.69666536
91MP0003566_abnormal_cell_adhesion0.69291708
92MP0005023_abnormal_wound_healing0.69273289
93MP0002138_abnormal_hepatobiliary_system0.69085563
94MP0003866_abnormal_defecation0.68083761
95MP0000490_abnormal_crypts_of0.67410058
96MP0001958_emphysema0.66588905
97MP0005076_abnormal_cell_differentiation0.65821583
98MP0003806_abnormal_nucleotide_metabolis0.65326219
99MP0002136_abnormal_kidney_physiology0.65260537
100MP0008874_decreased_physiological_sensi0.63825490
101MP0009765_abnormal_xenobiotic_induced0.63595741
102MP0004883_abnormal_blood_vessel0.59822530
103MP0003252_abnormal_bile_duct0.59471076
104MP0003787_abnormal_imprinting0.58792057
105MP0001986_abnormal_taste_sensitivity0.58278033
106MP0005075_abnormal_melanosome_morpholog0.57997879
107MP0000767_abnormal_smooth_muscle0.57537960
108MP0003943_abnormal_hepatobiliary_system0.56681533
109MP0008873_increased_physiological_sensi0.56642281
110MP0008004_abnormal_stomach_pH0.56635869
111MP0005376_homeostasis/metabolism_phenot0.56489417
112MP0000609_abnormal_liver_physiology0.56416170
113MP0003091_abnormal_cell_migration0.56346096
114MP0002928_abnormal_bile_duct0.55191951
115MP0004484_altered_response_of0.54441963
116MP0002132_abnormal_respiratory_system0.54358442
117MP0005388_respiratory_system_phenotype0.54281527
118MP0002133_abnormal_respiratory_system0.54281527
119MP0003195_calcinosis0.53909136
120MP0002019_abnormal_tumor_incidence0.53615086

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.98869759
2Eczematoid dermatitis (HP:0000976)6.33241640
3Recurrent bacterial skin infections (HP:0005406)6.31576127
4Recurrent gram-negative bacterial infections (HP:0005420)5.46159299
5Elevated erythrocyte sedimentation rate (HP:0003565)5.06227599
6Abnormality of macrophages (HP:0004311)4.75027570
7Vacuolated lymphocytes (HP:0001922)4.61007322
8Myositis (HP:0100614)4.54200199
9Autoimmune thrombocytopenia (HP:0001973)4.39230568
10Mediastinal lymphadenopathy (HP:0100721)4.33521281
11Orchitis (HP:0100796)4.22894747
12Increased cerebral lipofuscin (HP:0011813)4.15690115
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.04094310
14Systemic lupus erythematosus (HP:0002725)4.00311028
15Optic neuritis (HP:0100653)3.99056293
16Retrobulbar optic neuritis (HP:0100654)3.99056293
17Recurrent skin infections (HP:0001581)3.90933044
18Stomatitis (HP:0010280)3.90373035
19Recurrent fungal infections (HP:0002841)3.73729480
20T lymphocytopenia (HP:0005403)3.69959876
21Gingivitis (HP:0000230)3.69859153
22Cellulitis (HP:0100658)3.65740515
23Obstructive lung disease (HP:0006536)3.58576841
24Chronic obstructive pulmonary disease (HP:0006510)3.58576841
25Vasculitis (HP:0002633)3.50224416
26Chronic otitis media (HP:0000389)3.41502113
27Recurrent viral infections (HP:0004429)3.40972941
28Periodontitis (HP:0000704)3.31542670
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.14780872
30Meningitis (HP:0001287)3.12859261
31Pustule (HP:0200039)3.11606948
32Interstitial pulmonary disease (HP:0006530)3.09125636
33Abnormality of liposaccharide metabolism (HP:0010968)3.05103951
34Abnormality of glycosphingolipid metabolism (HP:0004343)3.05103951
35Abnormality of glycolipid metabolism (HP:0010969)3.05103951
36Peritonitis (HP:0002586)3.03033020
37Increased IgE level (HP:0003212)3.00105530
38Hypochromic microcytic anemia (HP:0004840)2.97769215
39Pulmonary infiltrates (HP:0002113)2.90585274
40Gingival bleeding (HP:0000225)2.79637170
41Leukocytosis (HP:0001974)2.79452641
42Osteomyelitis (HP:0002754)2.76706039
43Urticaria (HP:0001025)2.76680512
44Recurrent pneumonia (HP:0006532)2.75599554
45Petechiae (HP:0000967)2.74639420
46Glomerulonephritis (HP:0000099)2.73994649
47Dysostosis multiplex (HP:0000943)2.71514459
48Anorexia (HP:0002039)2.68835006
49Recurrent cutaneous fungal infections (HP:0011370)2.66545922
50Chronic mucocutaneous candidiasis (HP:0002728)2.66545922
51Hypochromic anemia (HP:0001931)2.66498071
52Increased IgM level (HP:0003496)2.64375539
53Basal ganglia calcification (HP:0002135)2.64357713
54Arterial thrombosis (HP:0004420)2.64218424
55Pulmonary embolism (HP:0002204)2.63382505
56Keratoconjunctivitis sicca (HP:0001097)2.61028704
57Panhypogammaglobulinemia (HP:0003139)2.57582622
58Episodic fever (HP:0001954)2.55439442
59Prolonged bleeding time (HP:0003010)2.54541621
60Prostate neoplasm (HP:0100787)2.50556327
61Viral hepatitis (HP:0006562)2.50138594
62Spontaneous hematomas (HP:0007420)2.49606915
63Abnormality of the peritoneum (HP:0002585)2.46680700
64Epistaxis (HP:0000421)2.46270851
65Fatigue (HP:0012378)2.44972642
66Axonal loss (HP:0003447)2.44801400
67Recurrent lower respiratory tract infections (HP:0002783)2.43347438
68Granulocytopenia (HP:0001913)2.43226017
69Hematochezia (HP:0002573)2.43039128
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42837219
71Inflammation of the large intestine (HP:0002037)2.41954311
72Gangrene (HP:0100758)2.41923338
73Recurrent bronchitis (HP:0002837)2.38117953
74Thick nail (HP:0001805)2.36033864
75Gastrointestinal stroma tumor (HP:0100723)2.34815906
76Abnormality of T cell physiology (HP:0011840)2.33556075
77Keratoconjunctivitis (HP:0001096)2.33127623
78Hemoptysis (HP:0002105)2.32995876
79Agammaglobulinemia (HP:0004432)2.32128268
80Abnormality of the endocardium (HP:0004306)2.30523872
81Tetraparesis (HP:0002273)2.29076161
82Abnormality of the prostate (HP:0008775)2.28379045
83Subacute progressive viral hepatitis (HP:0006572)2.24025137
84Gastrointestinal infarctions (HP:0005244)2.23628943
85Amyloidosis (HP:0011034)2.23289998
86Gastrointestinal inflammation (HP:0004386)2.22671110
87Hepatosplenomegaly (HP:0001433)2.22613810
88Hypergammaglobulinemia (HP:0010702)2.21487548
89Thrombocytosis (HP:0001894)2.20903054
90Abnormality of T cell number (HP:0011839)2.20037721
91Glomerulopathy (HP:0100820)2.19748620
92Myocardial infarction (HP:0001658)2.19473996
93Colitis (HP:0002583)2.19271858
94Slow saccadic eye movements (HP:0000514)2.18637308
95Disinhibition (HP:0000734)2.17871957
96Emphysema (HP:0002097)2.16449406
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15762821
98Lymphopenia (HP:0001888)2.15466737
99IgM deficiency (HP:0002850)2.15069160
100Abnormality of cells of the lymphoid lineage (HP:0012140)2.14868871
101Urinary glycosaminoglycan excretion (HP:0003541)2.14416835
102Mucopolysacchariduria (HP:0008155)2.14416835
103Microcytic anemia (HP:0001935)2.14055128
104Abnormality of the pleura (HP:0002103)2.13587615
105Cheilitis (HP:0100825)2.12984607
106Purpura (HP:0000979)2.12689913
107Eosinophilia (HP:0001880)2.11859228
108Nasal polyposis (HP:0100582)2.11731247
109Abnormality of the nasal mucosa (HP:0000433)2.11476742
110Abnormal delayed hypersensitivity skin test (HP:0002963)2.11426511
111Recurrent sinusitis (HP:0011108)2.10022651
112Agnosia (HP:0010524)2.09780922
113J-shaped sella turcica (HP:0002680)2.09087683
114Abnormality of polysaccharide metabolism (HP:0011012)2.08226586
115Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08226586
116Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08226586
117Chest pain (HP:0100749)2.07944861
118Encephalitis (HP:0002383)2.07296853
119Skin ulcer (HP:0200042)2.06531975
120Abnormality of T cells (HP:0002843)2.05566122
121Sepsis (HP:0100806)2.05280159
122Restrictive lung disease (HP:0002091)2.03422767
123Vertigo (HP:0002321)2.03418536
124Keratitis (HP:0000491)2.01360137
125Acute hepatic failure (HP:0006554)1.98711075
126Skin rash (HP:0000988)1.87218419
127Premature loss of primary teeth (HP:0006323)1.86547967
128Autoimmune hemolytic anemia (HP:0001890)1.85333972
129Abnormality of eosinophils (HP:0001879)1.85154659
130Papilloma (HP:0012740)1.84455975
131Verrucae (HP:0200043)1.84455975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.99984639
2MAP3K143.81152418
3IRAK43.26137852
4TBK13.20988075
5TXK3.18278786
6BLK3.01587318
7RIPK42.96871058
8TYK22.77920780
9IRAK32.68330969
10IKBKE2.59405874
11ERN12.56378423
12KIT2.41964121
13ZAP702.15788858
14JAK32.15693660
15TGFBR22.11084034
16STK162.10464186
17CSK1.98482330
18BTK1.97261543
19IKBKB1.97100802
20RIPK11.95162461
21PRPF4B1.85219881
22CSF1R1.83759095
23TAOK31.69181374
24STK101.68893380
25SYK1.66888020
26JAK11.65895285
27HCK1.56307525
28TEC1.53265688
29LYN1.49821128
30MST41.48919814
31FES1.45962077
32KSR21.42082635
33MAP3K31.36279648
34EPHB11.33491814
35LCK1.32551614
36MAP3K11.31981526
37MAP3K21.30676287
38CLK11.27025582
39TAOK11.25735904
40RPS6KA41.24391230
41ITK1.24285978
42CHUK1.21293726
43IRAK21.19367780
44PBK1.18278197
45PIM21.10595976
46MATK1.10321178
47FLT31.08137962
48MAP3K131.04935640
49PIM10.99031997
50MAP2K30.96903320
51FGR0.90149089
52JAK20.89249527
53TGFBR10.89227880
54NEK90.89150770
55MARK20.87528074
56FGFR40.87323967
57CDK190.87266213
58PTK2B0.87070300
59MAP3K60.86613571
60PDK10.86461338
61EIF2AK20.85610487
62GRK60.85371479
63STK40.84959893
64MARK30.81537665
65GRK70.80684252
66TRPM70.78612363
67NME20.76532816
68FGFR30.72874289
69ACVR1B0.72863623
70WNK10.69482876
71RAF10.68983769
72PDPK10.68787783
73MAP2K40.68160199
74LRRK20.67149185
75SGK30.66790743
76KSR10.64617952
77SIK30.64246272
78CAMKK20.63202156
79EGFR0.61715585
80TNK20.60690357
81SGK20.59901171
82MAP3K70.59800642
83CDC42BPA0.58906054
84PRKCD0.58834970
85STK110.58617473
86PRKD20.58364396
87PIK3CG0.56477597
88PKN20.55717391
89MAP3K100.51950826
90SIK20.50431275
91MAPK120.50302153
92BMX0.49723033
93BMPR1B0.49714390
94CAMKK10.48134172
95ABL10.47996944
96MAPK70.47030244
97IRAK10.46579625
98YES10.46559631
99MAP3K110.44956261
100MUSK0.44932099
101RET0.44497748
102NLK0.44219435
103RPS6KA60.43869411
104HIPK20.43577884
105BMPR20.42676672
106CAMK1D0.42527327
107MAPKAPK20.42443734
108MAP2K60.41661065
109PRKG20.41518371
110PRKCQ0.41268954
111EPHA30.41082275
112TAOK20.40405245
113FRK0.40060615
114DYRK1B0.39896119
115TTN0.39355823
116MAPK40.39286369
117TRIB30.38051906
118IGF1R0.37205665
119DAPK20.36252062
120CCNB10.35015125
121KDR0.33826865
122PAK40.33762135
123ADRBK20.33433518
124RPS6KC10.31424980
125RPS6KL10.31424980
126MOS0.30990815
127ABL20.30449842
128PTK60.30341462
129DYRK30.29593230
130FYN0.28697465
131INSR0.27892713
132MAPK110.27635923
133EIF2AK10.24983944
134CDK120.24194539
135STK30.23477149
136MAP3K120.23368070
137MAP3K50.22059332

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.52508194
2Staphylococcus aureus infection_Homo sapiens_hsa051503.44907645
3Graft-versus-host disease_Homo sapiens_hsa053322.98652180
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.83315120
5* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.72614812
6Osteoclast differentiation_Homo sapiens_hsa043802.54194845
7Legionellosis_Homo sapiens_hsa051342.41350054
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38371745
9Pertussis_Homo sapiens_hsa051332.34520133
10Malaria_Homo sapiens_hsa051442.31704787
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19104265
12Measles_Homo sapiens_hsa051622.16861818
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16301150
14Allograft rejection_Homo sapiens_hsa053302.14541149
15B cell receptor signaling pathway_Homo sapiens_hsa046622.06909284
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.03986154
17Primary immunodeficiency_Homo sapiens_hsa053402.03086902
18Lysosome_Homo sapiens_hsa041422.00538900
19* Tuberculosis_Homo sapiens_hsa051521.99015403
20Other glycan degradation_Homo sapiens_hsa005111.94072256
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.89842978
22Hematopoietic cell lineage_Homo sapiens_hsa046401.88177148
23Asthma_Homo sapiens_hsa053101.87704525
24Antigen processing and presentation_Homo sapiens_hsa046121.77186028
25Rheumatoid arthritis_Homo sapiens_hsa053231.75705654
26TNF signaling pathway_Homo sapiens_hsa046681.75320806
27Influenza A_Homo sapiens_hsa051641.66108182
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64532904
29* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64060489
30Herpes simplex infection_Homo sapiens_hsa051681.61968536
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.57470605
32Type I diabetes mellitus_Homo sapiens_hsa049401.56898248
33African trypanosomiasis_Homo sapiens_hsa051431.54304640
34Toxoplasmosis_Homo sapiens_hsa051451.53857687
35Salmonella infection_Homo sapiens_hsa051321.50065571
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43026218
37* Phagosome_Homo sapiens_hsa041451.41465637
38Chemokine signaling pathway_Homo sapiens_hsa040621.38521737
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37425621
40Apoptosis_Homo sapiens_hsa042101.32618621
41Non-small cell lung cancer_Homo sapiens_hsa052231.31963727
42Shigellosis_Homo sapiens_hsa051311.31858327
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.27960124
44Hepatitis B_Homo sapiens_hsa051611.11365484
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10051652
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99832014
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.99824440
48T cell receptor signaling pathway_Homo sapiens_hsa046600.98273629
49Viral myocarditis_Homo sapiens_hsa054160.97006003
50Hepatitis C_Homo sapiens_hsa051600.96052460
51Renal cell carcinoma_Homo sapiens_hsa052110.93075452
52Autoimmune thyroid disease_Homo sapiens_hsa053200.90298154
53Complement and coagulation cascades_Homo sapiens_hsa046100.89004643
54Dorso-ventral axis formation_Homo sapiens_hsa043200.87589654
55Platelet activation_Homo sapiens_hsa046110.87366613
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85967811
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84154420
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81745428
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78915551
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73730176
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70442962
62Acute myeloid leukemia_Homo sapiens_hsa052210.70059042
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68970581
64Amoebiasis_Homo sapiens_hsa051460.68833472
65Caffeine metabolism_Homo sapiens_hsa002320.68463149
66Chronic myeloid leukemia_Homo sapiens_hsa052200.67354862
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67164070
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66217312
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65128976
70GnRH signaling pathway_Homo sapiens_hsa049120.63463465
71Pancreatic cancer_Homo sapiens_hsa052120.62894535
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.61585580
73Endometrial cancer_Homo sapiens_hsa052130.60113993
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57806731
75Epstein-Barr virus infection_Homo sapiens_hsa051690.57375840
76ABC transporters_Homo sapiens_hsa020100.57054057
77Inositol phosphate metabolism_Homo sapiens_hsa005620.55774942
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.55266824
79mTOR signaling pathway_Homo sapiens_hsa041500.54643792
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52287377
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51890700
82Choline metabolism in cancer_Homo sapiens_hsa052310.51221161
83ErbB signaling pathway_Homo sapiens_hsa040120.49695677
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49217078
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.49174925
86Prion diseases_Homo sapiens_hsa050200.48228327
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.47973408
88MAPK signaling pathway_Homo sapiens_hsa040100.45982708
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45610173
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45566121
91Prostate cancer_Homo sapiens_hsa052150.45158441
92Small cell lung cancer_Homo sapiens_hsa052220.44923315
93Viral carcinogenesis_Homo sapiens_hsa052030.43709306
94Notch signaling pathway_Homo sapiens_hsa043300.43435127
95Colorectal cancer_Homo sapiens_hsa052100.42486666
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41289562
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41196853
98Estrogen signaling pathway_Homo sapiens_hsa049150.39822644
99Glioma_Homo sapiens_hsa052140.38696852
100Rap1 signaling pathway_Homo sapiens_hsa040150.36911103
101Prolactin signaling pathway_Homo sapiens_hsa049170.36859317
102HIF-1 signaling pathway_Homo sapiens_hsa040660.36618603
103Regulation of autophagy_Homo sapiens_hsa041400.36589536
104HTLV-I infection_Homo sapiens_hsa051660.34934479
105p53 signaling pathway_Homo sapiens_hsa041150.29367065
106Sphingolipid metabolism_Homo sapiens_hsa006000.29072634
107Insulin resistance_Homo sapiens_hsa049310.26629852
108Endocytosis_Homo sapiens_hsa041440.23737124
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22640748
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21408664
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20484935
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16959481
113FoxO signaling pathway_Homo sapiens_hsa040680.16845474
114Systemic lupus erythematosus_Homo sapiens_hsa053220.16027865
115Type II diabetes mellitus_Homo sapiens_hsa049300.15529667
116VEGF signaling pathway_Homo sapiens_hsa043700.15274146
117MicroRNAs in cancer_Homo sapiens_hsa052060.15252729
118Mineral absorption_Homo sapiens_hsa049780.13664827
119Galactose metabolism_Homo sapiens_hsa000520.13641368
120Proteoglycans in cancer_Homo sapiens_hsa052050.12615743
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10586564
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10214090

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