TLR8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.83221754
2* positive regulation by organism of defense response of other organism involved in symbiotic interact7.83221754
3* modulation by symbiont of host immune response (GO:0052553)7.83221754
4* positive regulation by symbiont of host defense response (GO:0052509)7.83221754
5* modulation by symbiont of host defense response (GO:0052031)7.83221754
6* modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.83221754
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.27287388
8* regulation of interferon-beta biosynthetic process (GO:0045357)5.91079007
9neutrophil activation involved in immune response (GO:0002283)5.81278345
10* macrophage activation involved in immune response (GO:0002281)5.29461978
11detection of other organism (GO:0098543)5.10523358
12response to peptidoglycan (GO:0032494)5.03664046
13* positive regulation of interferon-alpha production (GO:0032727)5.02126783
14* response to host immune response (GO:0052572)5.00640204
15* response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.00640204
16detection of external biotic stimulus (GO:0098581)4.81820498
17* regulation of interferon-alpha production (GO:0032647)4.73981846
18detection of bacterium (GO:0016045)4.53610309
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.50800377
20* positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.49501614
21antigen processing and presentation of endogenous antigen (GO:0019883)4.47928861
22respiratory burst (GO:0045730)4.46177275
23* response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.45604971
24* response to host (GO:0075136)4.45604971
25* response to host defenses (GO:0052200)4.45604971
26regulation of B cell receptor signaling pathway (GO:0050855)4.39839633
27regulation of gamma-delta T cell activation (GO:0046643)4.34922390
28detection of biotic stimulus (GO:0009595)4.24596555
29positive regulation of mast cell activation (GO:0033005)4.18593255
30* microglial cell activation (GO:0001774)4.15005977
31I-kappaB phosphorylation (GO:0007252)4.12074374
32regulation of cholesterol storage (GO:0010885)4.08702309
33leukocyte aggregation (GO:0070486)4.08603405
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05789645
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.99335440
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.97553001
37neutrophil activation (GO:0042119)3.95771293
38neutrophil mediated immunity (GO:0002446)3.92680838
39granulocyte activation (GO:0036230)3.89894935
40pinocytosis (GO:0006907)3.83794655
41* macrophage activation (GO:0042116)3.80317485
42* myeloid cell activation involved in immune response (GO:0002275)3.75633417
43positive regulation of antigen processing and presentation (GO:0002579)3.75544318
44negative regulation of T cell mediated immunity (GO:0002710)3.74913613
45* immunoglobulin mediated immune response (GO:0016064)3.74264801
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69956913
47detection of molecule of bacterial origin (GO:0032490)3.69339842
48negative regulation of interleukin-17 production (GO:0032700)3.63281969
49positive regulation of cellular amide metabolic process (GO:0034250)3.61442802
50production of molecular mediator involved in inflammatory response (GO:0002532)3.61349748
51regulation of gamma-delta T cell differentiation (GO:0045586)3.59985982
52regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.59427825
53regulation of mast cell activation (GO:0033003)3.56955291
54cellular extravasation (GO:0045123)3.54524816
55* positive regulation of interferon-beta production (GO:0032728)3.52298974
56negative regulation of leukocyte mediated immunity (GO:0002704)3.50434933
57regulation of mast cell degranulation (GO:0043304)3.48673060
58apoptotic cell clearance (GO:0043277)3.48582356
59response to interleukin-15 (GO:0070672)3.48479598
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45933050
61positive regulation of gamma-delta T cell activation (GO:0046645)3.45920226
62regulation of mononuclear cell migration (GO:0071675)3.45363150
63defense response to protozoan (GO:0042832)3.44829024
64regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.42821535
65positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.41202360
66positive regulation of macrophage cytokine production (GO:0060907)3.40745772
67lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40470240
68regulation of tolerance induction (GO:0002643)3.38950944
69regulation of T cell tolerance induction (GO:0002664)3.31922949
70regulation of mast cell activation involved in immune response (GO:0033006)3.29412890
71antigen processing and presentation via MHC class Ib (GO:0002475)3.28147064
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.27550230
73positive regulation of toll-like receptor signaling pathway (GO:0034123)3.26702798
74lipoprotein transport (GO:0042953)3.24828251
75positive regulation of leukocyte degranulation (GO:0043302)3.24580829
76regulation of leukocyte degranulation (GO:0043300)3.24373408
77negative regulation of cell killing (GO:0031342)3.23829402
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23829402
79negative regulation of mast cell activation (GO:0033004)3.21162586
80hydrogen peroxide biosynthetic process (GO:0050665)3.20899022
81positive regulation of mast cell activation involved in immune response (GO:0033008)3.18442173
82positive regulation of mast cell degranulation (GO:0043306)3.18442173
83B cell receptor signaling pathway (GO:0050853)3.15378844
84germinal center formation (GO:0002467)3.15377428
85regulation of T-helper 2 cell differentiation (GO:0045628)3.14916690
86positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.14525889
87cellular response to interleukin-15 (GO:0071350)3.12998458
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11299859
89response to muramyl dipeptide (GO:0032495)3.09146050
90natural killer cell mediated immunity (GO:0002228)3.09123908
91natural killer cell mediated cytotoxicity (GO:0042267)3.09123908
92regulation of antigen processing and presentation (GO:0002577)3.08350385
93response to protozoan (GO:0001562)3.07111217
94low-density lipoprotein particle clearance (GO:0034383)3.06460276
95positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06389294
96cellular response to thyroid hormone stimulus (GO:0097067)3.05008023
97dendritic cell migration (GO:0036336)3.04369994
98negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03925563
99dendritic cell chemotaxis (GO:0002407)3.02044199
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99277103
101regulation of macrophage cytokine production (GO:0010935)2.99126673
102* regulation of interleukin-8 biosynthetic process (GO:0045414)2.98437105
103positive regulation of B cell differentiation (GO:0045579)2.96775540
104response to interferon-alpha (GO:0035455)2.96690814
105positive regulation of tolerance induction (GO:0002645)2.96672727
106cellular response to interferon-alpha (GO:0035457)2.96386507
107T cell migration (GO:0072678)2.95393558
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94368206
109negative regulation of cytokine production involved in immune response (GO:0002719)2.94339737
110mannose metabolic process (GO:0006013)2.92296758
111leukocyte degranulation (GO:0043299)2.92175131
112regulation of alpha-beta T cell proliferation (GO:0046640)2.91928464
113negative regulation of erythrocyte differentiation (GO:0045647)2.90757148
114neutrophil chemotaxis (GO:0030593)2.89922203
115response to lipoprotein particle (GO:0055094)2.89722318
116regulation of T cell mediated cytotoxicity (GO:0001914)2.89458627
117positive regulation of type 2 immune response (GO:0002830)2.88098264
118negative regulation of type 2 immune response (GO:0002829)2.87825341
119positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87592807
120myeloid leukocyte mediated immunity (GO:0002444)2.87542848
121regulation of B cell differentiation (GO:0045577)2.86338554
122lymphocyte chemotaxis (GO:0048247)2.85898746
123superoxide anion generation (GO:0042554)2.82598709
124reactive oxygen species biosynthetic process (GO:1903409)2.82565307
125regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81505625
126neutrophil migration (GO:1990266)2.81448196
127negative regulation of lipid storage (GO:0010888)2.81402241
128T-helper 1 type immune response (GO:0042088)2.80995146
129leukocyte mediated cytotoxicity (GO:0001909)2.80353286
130negative regulation of interleukin-12 production (GO:0032695)2.80300516
131* myeloid leukocyte activation (GO:0002274)2.78551259
132positive regulation of T cell apoptotic process (GO:0070234)2.76757716
133leukocyte migration involved in inflammatory response (GO:0002523)2.75351880
134interferon-gamma-mediated signaling pathway (GO:0060333)2.74213765
135positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73625530
136type I interferon signaling pathway (GO:0060337)2.72675732
137cellular response to type I interferon (GO:0071357)2.72675732
138phagosome maturation (GO:0090382)2.71890361
139positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.71823733
140positive regulation of chemokine production (GO:0032722)2.71745788
141response to type I interferon (GO:0034340)2.71034750
142negative regulation of granulocyte differentiation (GO:0030853)2.69307523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.16744102
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.24819782
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.42466709
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.97429321
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.72671855
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.35683452
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.16897694
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39808896
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.27398820
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05382498
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02321328
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.62715343
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58807098
14BRD4_27068464_Chip-Seq_AML-cells_Mouse2.54648371
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54177132
16* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49044795
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.45431254
18* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40561078
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.34508268
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32577059
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.32480282
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22268264
23SPI1_23547873_ChIP-Seq_NB4_Human2.16629610
24SPI1_23127762_ChIP-Seq_K562_Human2.12439662
25PU_27001747_Chip-Seq_BMDM_Mouse1.97332865
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94203648
27VDR_24787735_ChIP-Seq_THP-1_Human1.86162613
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80979111
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79855041
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77835633
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.76277002
32SCL_19346495_ChIP-Seq_HPC-7_Human1.73051981
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71890249
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71853408
35VDR_24763502_ChIP-Seq_THP-1_Human1.71002532
36GATA1_22025678_ChIP-Seq_K562_Human1.70730512
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68141977
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65185872
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64211924
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61831962
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.53391347
42VDR_21846776_ChIP-Seq_THP-1_Human1.52833469
43RUNX_20019798_ChIP-Seq_JUKART_Human1.47891301
44MYB_26560356_Chip-Seq_TH2_Human1.46991837
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45856715
46* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44041598
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42606977
48MAF_26560356_Chip-Seq_TH1_Human1.42187202
49CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41466449
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40412527
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40342553
52MYC_22102868_ChIP-Seq_BL_Human1.39495676
53MAF_26560356_Chip-Seq_TH2_Human1.35445990
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31526330
55MYB_26560356_Chip-Seq_TH1_Human1.25404026
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25345391
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20641157
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19730656
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19698448
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17282439
61GATA3_26560356_Chip-Seq_TH2_Human1.15216234
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12844673
63GATA3_27048872_Chip-Seq_THYMUS_Human1.12500634
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11496770
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.10453976
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09080061
67TFEB_21752829_ChIP-Seq_HELA_Human1.08926894
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08849560
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04594156
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.04202611
71UTX_26944678_Chip-Seq_JUKART_Human1.04016360
72TCF7_22412390_ChIP-Seq_EML_Mouse1.02979060
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00581031
74GATA1_19941826_ChIP-Seq_K562_Human0.99181860
75ELK3_25401928_ChIP-Seq_HUVEC_Human0.99098480
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98588504
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98059632
78PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97314323
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97160910
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96694810
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96372284
82KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94045831
83FOXO3_23340844_ChIP-Seq_DLD1_Human0.92928721
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.92466230
85KDM2B_26808549_Chip-Seq_JURKAT_Human0.91009878
86GATA2_19941826_ChIP-Seq_K562_Human0.90862355
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89553473
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89276727
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89115502
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86451408
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85995416
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84110195
93IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83998422
94KDM2B_26808549_Chip-Seq_DND41_Human0.83567566
95SPI1_20517297_ChIP-Seq_HL60_Human0.80644793
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80404649
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80404649
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80305169
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.80184577
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79292126
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79225249
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78751137
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77134003
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75177909
105EGR1_19032775_ChIP-ChIP_M12_Human0.75017063
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74809745
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74286147
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73860117
109SOX2_20726797_ChIP-Seq_SW620_Human0.73779889
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73371799
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73277175
112ELF1_17652178_ChIP-ChIP_JURKAT_Human0.72593184
113* SMRT_27268052_Chip-Seq_Bcells_Human0.72017044
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71492242
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70735539
116NCOR1_26117541_ChIP-Seq_K562_Human0.70701000
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70467946
118LXR_22292898_ChIP-Seq_THP-1_Human0.66661434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.92835028
2MP0001835_abnormal_antigen_presentation3.96151716
3MP0003303_peritoneal_inflammation3.90730612
4MP0003436_decreased_susceptibility_to3.75136856
5MP0003172_abnormal_lysosome_physiology3.25513491
6MP0002419_abnormal_innate_immunity3.25329385
7MP0006082_CNS_inflammation3.19075363
8MP0009840_abnormal_foam_cell2.85531890
9MP0000569_abnormal_digit_pigmentation2.75888519
10* MP0005000_abnormal_immune_tolerance2.67521050
11MP0003191_abnormal_cellular_cholesterol2.59342618
12MP0009785_altered_susceptibility_to2.58789580
13MP0002148_abnormal_hypersensitivity_rea2.47757345
14MP0005025_abnormal_response_to2.46654442
15MP0005387_immune_system_phenotype2.44299563
16MP0001790_abnormal_immune_system2.44299563
17MP0003724_increased_susceptibility_to2.40883918
18* MP0002452_abnormal_antigen_presenting2.38012913
19MP0003690_abnormal_glial_cell2.25070145
20MP0000604_amyloidosis2.24133515
21MP0004510_myositis2.14803978
22MP0001533_abnormal_skeleton_physiology2.11088445
23* MP0002723_abnormal_immune_serum2.08959682
24* MP0001800_abnormal_humoral_immune2.08744612
25MP0003300_gastrointestinal_ulcer2.08020995
26MP0005464_abnormal_platelet_physiology2.02437220
27MP0005451_abnormal_body_composition2.01303771
28MP0000685_abnormal_immune_system1.91802242
29* MP0001819_abnormal_immune_cell1.89295714
30* MP0002420_abnormal_adaptive_immunity1.87336507
31MP0003183_abnormal_peptide_metabolism1.77200959
32MP0003075_altered_response_to1.76222037
33MP0009278_abnormal_bone_marrow1.74214216
34MP0000343_altered_response_to1.73428367
35MP0003448_altered_tumor_morphology1.72419986
36MP0002405_respiratory_system_inflammati1.71703018
37MP0005310_abnormal_salivary_gland1.67089154
38MP0003763_abnormal_thymus_physiology1.64903970
39* MP0001845_abnormal_inflammatory_respons1.64677482
40MP0005671_abnormal_response_to1.64334171
41MP0004947_skin_inflammation1.58024592
42* MP0008469_abnormal_protein_level1.57222945
43MP0002132_abnormal_respiratory_system1.54015304
44MP0009764_decreased_sensitivity_to1.46417958
45MP0005166_decreased_susceptibility_to1.42122642
46MP0010307_abnormal_tumor_latency1.41643911
47MP0002998_abnormal_bone_remodeling1.41481761
48MP0001853_heart_inflammation1.40545743
49MP0003566_abnormal_cell_adhesion1.35743914
50MP0003705_abnormal_hypodermis_morpholog1.35738439
51MP0005174_abnormal_tail_pigmentation1.31379275
52MP0000465_gastrointestinal_hemorrhage1.31131250
53* MP0000716_abnormal_immune_system1.30581690
54MP0005167_abnormal_blood-brain_barrier1.30459087
55MP0003866_abnormal_defecation1.29295370
56MP0001851_eye_inflammation1.27000905
57MP0008438_abnormal_cutaneous_collagen1.26997236
58MP0005257_abnormal_intraocular_pressure1.25350765
59* MP0000689_abnormal_spleen_morphology1.23029697
60MP0010155_abnormal_intestine_physiology1.21213513
61MP0004381_abnormal_hair_follicle1.19975774
62MP0000858_altered_metastatic_potential1.19753782
63MP0005083_abnormal_biliary_tract1.19288802
64MP0005397_hematopoietic_system_phenotyp1.18134961
65MP0001545_abnormal_hematopoietic_system1.18134961
66MP0008004_abnormal_stomach_pH1.16394951
67MP0002398_abnormal_bone_marrow1.14318121
68MP0003828_pulmonary_edema1.13726822
69MP0003656_abnormal_erythrocyte_physiolo1.11187170
70MP0000703_abnormal_thymus_morphology1.11091059
71MP0002166_altered_tumor_susceptibility1.06380794
72MP0004130_abnormal_muscle_cell1.04959168
73* MP0002429_abnormal_blood_cell1.04820857
74MP0001958_emphysema1.03507704
75MP0005076_abnormal_cell_differentiation1.01473707
76MP0009763_increased_sensitivity_to0.99434357
77MP0002090_abnormal_vision0.97858320
78MP0005390_skeleton_phenotype0.96503023
79* MP0002722_abnormal_immune_system0.95649058
80MP0002396_abnormal_hematopoietic_system0.95291819
81MP0002277_abnormal_respiratory_mucosa0.95200665
82MP0002006_tumorigenesis0.94846086
83MP0009333_abnormal_splenocyte_physiolog0.91984598
84MP0002933_joint_inflammation0.91164162
85MP0005164_abnormal_response_to0.91020803
86MP0002332_abnormal_exercise_endurance0.89416807
87MP0002254_reproductive_system_inflammat0.89088787
88MP0004782_abnormal_surfactant_physiolog0.88564069
89MP0003221_abnormal_cardiomyocyte_apopto0.85193054
90MP0000920_abnormal_myelination0.82476907
91MP0008260_abnormal_autophagy0.81407583
92MP0010386_abnormal_urinary_bladder0.80199046
93MP0000015_abnormal_ear_pigmentation0.77873442
94MP0000249_abnormal_blood_vessel0.76811979
95MP0000609_abnormal_liver_physiology0.76557453
96MP0006054_spinal_hemorrhage0.76242002
97MP0009765_abnormal_xenobiotic_induced0.74288595
98MP0003795_abnormal_bone_structure0.73998864
99MP0010329_abnormal_lipoprotein_level0.73915560
100MP0003806_abnormal_nucleotide_metabolis0.70939374
101MP0008874_decreased_physiological_sensi0.70842563
102MP0003091_abnormal_cell_migration0.70107449
103MP0004883_abnormal_blood_vessel0.69060646
104MP0003045_fibrosis0.67332278
105MP0000767_abnormal_smooth_muscle0.67163320
106MP0000371_diluted_coat_color0.67026415
107MP0001873_stomach_inflammation0.65670914
108MP0003329_amyloid_beta_deposits0.64588418
109MP0005075_abnormal_melanosome_morpholog0.63467747
110MP0000598_abnormal_liver_morphology0.59350318
111MP0003195_calcinosis0.58775520
112MP0003634_abnormal_glial_cell0.58762581
113* MP0002136_abnormal_kidney_physiology0.58668786
114MP0003453_abnormal_keratinocyte_physiol0.57605588
115MP0004808_abnormal_hematopoietic_stem0.57341218
116MP0005319_abnormal_enzyme/_coenzyme0.56836015
117MP0003186_abnormal_redox_activity0.56707287
118MP0001663_abnormal_digestive_system0.56481345
119MP0004484_altered_response_of0.55635108
120MP0005376_homeostasis/metabolism_phenot0.53157157
121MP0002133_abnormal_respiratory_system0.48871888
122MP0005388_respiratory_system_phenotype0.48871888

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.94803768
2Increased cerebral lipofuscin (HP:0011813)6.61499036
3Vacuolated lymphocytes (HP:0001922)6.27457284
4Recurrent bacterial skin infections (HP:0005406)6.14270995
5Recurrent gram-negative bacterial infections (HP:0005420)5.87546819
6Eczematoid dermatitis (HP:0000976)5.82695489
7Increased neuronal autofluorescent lipopigment (HP:0002074)5.40432002
8Systemic lupus erythematosus (HP:0002725)5.27914465
9Abnormality of macrophages (HP:0004311)5.17252469
10Dysostosis multiplex (HP:0000943)4.77065970
11Abnormality of glycolipid metabolism (HP:0010969)4.63815589
12Abnormality of liposaccharide metabolism (HP:0010968)4.63815589
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.63815589
14Gastrointestinal infarctions (HP:0005244)4.46570647
15Disinhibition (HP:0000734)4.44197466
16Keratoconjunctivitis sicca (HP:0001097)4.21319596
17Axonal loss (HP:0003447)4.10126002
18Keratoconjunctivitis (HP:0001096)3.87628899
19Mucopolysacchariduria (HP:0008155)3.81893309
20Urinary glycosaminoglycan excretion (HP:0003541)3.81893309
21Gingivitis (HP:0000230)3.77181100
22Glomerulonephritis (HP:0000099)3.69416678
23Loss of speech (HP:0002371)3.68583201
24Recurrent skin infections (HP:0001581)3.67500595
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.65539068
26Abnormality of polysaccharide metabolism (HP:0011012)3.65539068
27Abnormality of glycosaminoglycan metabolism (HP:0004371)3.65539068
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.57202149
29Encephalitis (HP:0002383)3.55315570
30Autoimmune thrombocytopenia (HP:0001973)3.53130741
31T lymphocytopenia (HP:0005403)3.52392037
32Mediastinal lymphadenopathy (HP:0100721)3.51674083
33Myocardial infarction (HP:0001658)3.40031306
34Prostate neoplasm (HP:0100787)3.39367083
35Chronic obstructive pulmonary disease (HP:0006510)3.37741712
36Obstructive lung disease (HP:0006536)3.37741712
37Myositis (HP:0100614)3.35201763
38Hemoptysis (HP:0002105)3.34782130
39Abnormality of T cell number (HP:0011839)3.33972785
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.30760572
41Orchitis (HP:0100796)3.30075224
42Peritonitis (HP:0002586)3.13748113
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.13507922
44Agnosia (HP:0010524)3.10389477
45Chest pain (HP:0100749)3.09958684
46Recurrent fungal infections (HP:0002841)2.99812573
47Upper motor neuron abnormality (HP:0002127)2.98743419
48Periodontitis (HP:0000704)2.93785678
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.93234016
50Optic neuritis (HP:0100653)2.89238853
51Retrobulbar optic neuritis (HP:0100654)2.89238853
52Anorexia (HP:0002039)2.87580158
53Hepatosplenomegaly (HP:0001433)2.86962577
54Increased IgE level (HP:0003212)2.84895471
55Episodic fever (HP:0001954)2.82827770
56Hematochezia (HP:0002573)2.78066486
57Gangrene (HP:0100758)2.75997359
58Pulmonary embolism (HP:0002204)2.75805791
59Prolonged bleeding time (HP:0003010)2.72168331
60Thick nail (HP:0001805)2.71074218
61Complement deficiency (HP:0004431)2.65370905
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.62068139
63Pustule (HP:0200039)2.61262078
64Abnormality of complement system (HP:0005339)2.59542560
65Abnormality of the lumbar spine (HP:0100712)2.57532182
66Basal ganglia calcification (HP:0002135)2.56952790
67Urticaria (HP:0001025)2.56545084
68J-shaped sella turcica (HP:0002680)2.55497845
69Epistaxis (HP:0000421)2.53948126
70Stomatitis (HP:0010280)2.53276095
71Elevated erythrocyte sedimentation rate (HP:0003565)2.52449869
72Cellulitis (HP:0100658)2.50607114
73Increased IgM level (HP:0003496)2.49610354
74Recurrent viral infections (HP:0004429)2.49449222
75Nephritis (HP:0000123)2.48747271
76Abnormality of T cells (HP:0002843)2.47068270
77Peripheral demyelination (HP:0011096)2.46537588
78Spontaneous hematomas (HP:0007420)2.46296367
79Thoracic kyphosis (HP:0002942)2.44844490
80Joint hemorrhage (HP:0005261)2.43939171
81Pathologic fracture (HP:0002756)2.41532582
82Abnormality of the pleura (HP:0002103)2.38098021
83Inappropriate behavior (HP:0000719)2.35915844
84Conjunctival telangiectasia (HP:0000524)2.35630447
85Abnormality of the endocardium (HP:0004306)2.35299520
86Diminished motivation (HP:0000745)2.34134661
87Vasculitis (HP:0002633)2.33722443
88Apathy (HP:0000741)2.33176284
89Neuronal loss in central nervous system (HP:0002529)2.32544332
90Abnormality of the peritoneum (HP:0002585)2.30033805
91Asymmetric septal hypertrophy (HP:0001670)2.29630254
92Gastrointestinal inflammation (HP:0004386)2.25610378
93Increased CSF protein (HP:0002922)2.24997357
94Osteolytic defects of the hand bones (HP:0009699)2.24515940
95Osteolytic defects of the phalanges of the hand (HP:0009771)2.24515940
96Vertigo (HP:0002321)2.24194881
97Osteomyelitis (HP:0002754)2.22521966
98Hypochromic microcytic anemia (HP:0004840)2.22079213
99Global brain atrophy (HP:0002283)2.21117501
100Granulocytopenia (HP:0001913)2.18304822
101Glomerulopathy (HP:0100820)2.16424565
102Hypochromic anemia (HP:0001931)2.14310256
103Sepsis (HP:0100806)2.14284976
104Hypercholesterolemia (HP:0003124)2.13925191
105Petechiae (HP:0000967)2.11983443
106Chronic mucocutaneous candidiasis (HP:0002728)2.09835601
107Recurrent cutaneous fungal infections (HP:0011370)2.09835601
108Interstitial pulmonary disease (HP:0006530)2.09829398
109Progressive visual loss (HP:0000529)2.08088207
110Polyneuropathy (HP:0001271)2.07665523
111Mutism (HP:0002300)2.07202801
112Keratitis (HP:0000491)2.06887799
113Acne (HP:0001061)2.06685394
114Arterial thrombosis (HP:0004420)2.06189396
115Amaurosis fugax (HP:0100576)2.05862258
116Hypergammaglobulinemia (HP:0010702)2.05031597
117Slow saccadic eye movements (HP:0000514)2.04902688
118Personality changes (HP:0000751)2.02725378
119Gingival bleeding (HP:0000225)2.02480215
120Purpura (HP:0000979)2.02425620
121Eosinophilia (HP:0001880)2.02204352
122Colitis (HP:0002583)1.98223635
123Increased serum ferritin (HP:0003281)1.98179983
124Retinal atrophy (HP:0001105)1.98138917
125Bone pain (HP:0002653)1.97549551
126Esophageal varix (HP:0002040)1.96559737
127Leukocytosis (HP:0001974)1.96361489
128Pulmonary infiltrates (HP:0002113)1.95678074
129Recurrent pneumonia (HP:0006532)1.95439782
130Subacute progressive viral hepatitis (HP:0006572)1.94945566
131Meningitis (HP:0001287)1.93166542
132Abnormality of the thoracic spine (HP:0100711)1.93142903
133Tetraparesis (HP:0002273)1.91278918
134Skin ulcer (HP:0200042)1.90651217
135Cheilitis (HP:0100825)1.89531767
136Viral hepatitis (HP:0006562)1.89191827
137Abnormality of the pericardium (HP:0001697)1.88072191
138Abnormality of the prostate (HP:0008775)1.87755508
139Deformed sella turcica (HP:0002681)1.87411325
140Inflammation of the large intestine (HP:0002037)1.86718513
141Thrombophlebitis (HP:0004418)1.86644203
142Panhypogammaglobulinemia (HP:0003139)1.85348913
143Acute hepatic failure (HP:0006554)1.84364910
144Lymphopenia (HP:0001888)1.84356349
145Neurofibrillary tangles (HP:0002185)1.83477199
146Microcytic anemia (HP:0001935)1.82801522
147Supranuclear gaze palsy (HP:0000605)1.80595328
148Chronic otitis media (HP:0000389)1.80557431
149Amyloidosis (HP:0011034)1.74870754
150Premature loss of primary teeth (HP:0006323)1.74719491
151Spondylolisthesis (HP:0003302)1.72018172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.03235718
2BLK3.88456416
3TYK23.44964938
4KIT3.17464028
5IRAK42.96346896
6TBK12.83745080
7ERN12.81486642
8MAP4K12.57857443
9MAP3K142.37104900
10TGFBR22.28182471
11PRPF4B2.20144044
12IRAK32.10131996
13TAOK32.07845682
14JAK12.06203325
15CAMK1D2.05689016
16CSK1.97883274
17RIPK11.93656920
18CSF1R1.89761415
19FGR1.89241845
20IKBKE1.86612456
21FES1.81619919
22HCK1.64557612
23TAOK11.61868909
24TRIB31.61491791
25TTN1.59691356
26MAP2K31.57863268
27TNK21.56592612
28SCYL21.56578683
29JAK31.53011399
30IKBKB1.52373370
31PBK1.52311138
32MAP3K131.46723748
33EPHB11.45286981
34CAMK1G1.38867978
35IRAK11.37369098
36NEK91.36861874
37JAK21.35758740
38ZAP701.35708004
39SYK1.35583817
40IRAK21.25650801
41STK101.22239313
42LYN1.21288238
43MATK1.18132366
44CAMKK21.16185324
45BTK1.11334800
46PKN21.08688621
47LCK1.08384245
48MAP3K61.06990849
49TRPM70.98891432
50MAP3K30.96359832
51MARK30.96326221
52TAOK20.95640705
53SIK30.94241007
54TEC0.92466183
55PTK60.91114993
56EGFR0.89923402
57RPS6KA40.89215442
58GRK70.88843521
59MARK20.86317773
60TXK0.86285970
61PIM20.85224737
62ABL20.84032698
63PAK40.81461355
64LRRK20.79552750
65CDK60.77627563
66FGFR30.76829047
67ITK0.76746757
68KSR20.75446099
69GRK60.74868762
70CAMKK10.74784788
71SIK20.74294832
72NME20.72826599
73CLK10.71871440
74PRKCD0.71343019
75EPHA30.70883352
76ABL10.69942724
77CDC42BPA0.69203930
78PIM10.68879826
79MAP3K20.68544884
80MAP2K40.67294127
81CHUK0.67228944
82MAP3K110.64654382
83FYN0.64171067
84FGFR40.63258959
85KSR10.63119642
86STK40.62887189
87MAP3K50.58605651
88DAPK20.57916405
89RAF10.57326900
90MOS0.55843723
91PTK2B0.55640479
92PDPK10.55405982
93DYRK1B0.55210027
94BMX0.55022528
95MAP2K60.51658778
96CDK190.50184167
97STK30.49629348
98PDK10.49244942
99SGK20.48987831
100STK110.48562055
101PRKD20.48559945
102NLK0.48177176
103DYRK30.47505257
104PRKCH0.44674673
105HIPK20.44347763
106WNK10.43708591
107MAPK70.43378454
108RET0.43203058
109CDK120.41075035
110ACVR1B0.40973472
111MAPK120.40203561
112YES10.39943635
113ERBB30.39722578
114DMPK0.39141145
115RPS6KL10.37945905
116RPS6KC10.37945905
117SGK30.37616404
118IGF1R0.36102190
119PRKCQ0.35617595
120MAP3K70.35183397
121MAPKAPK20.34563458
122PDGFRB0.34440579
123MAP3K10.34142210
124BMPR20.32185830
125RPS6KA60.31083233
126PIK3CG0.28867874
127GSK3A0.28219169
128TESK10.27418955
129SRC0.26642927
130CDK90.26590329
131TESK20.26024397
132DAPK30.25509298
133KDR0.24319356

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.33963066
2Lysosome_Homo sapiens_hsa041423.64051471
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.63400894
4Leishmaniasis_Homo sapiens_hsa051403.25243931
5Other glycan degradation_Homo sapiens_hsa005112.75380471
6Osteoclast differentiation_Homo sapiens_hsa043802.64273633
7Tuberculosis_Homo sapiens_hsa051522.55281734
8Phagosome_Homo sapiens_hsa041452.54611503
9* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42543531
10Pertussis_Homo sapiens_hsa051332.30654038
11Malaria_Homo sapiens_hsa051442.20463277
12Autoimmune thyroid disease_Homo sapiens_hsa053202.01089442
13Legionellosis_Homo sapiens_hsa051341.92263421
14B cell receptor signaling pathway_Homo sapiens_hsa046621.89111094
15Rheumatoid arthritis_Homo sapiens_hsa053231.87256948
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.82709930
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81622656
18Caffeine metabolism_Homo sapiens_hsa002321.74740745
19Complement and coagulation cascades_Homo sapiens_hsa046101.70516671
20Type I diabetes mellitus_Homo sapiens_hsa049401.67995781
21Measles_Homo sapiens_hsa051621.66951569
22Antigen processing and presentation_Homo sapiens_hsa046121.50707406
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50510534
24Influenza A_Homo sapiens_hsa051641.49530877
25Salmonella infection_Homo sapiens_hsa051321.48468385
26Toxoplasmosis_Homo sapiens_hsa051451.46304716
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46225021
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41271488
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37844575
30Shigellosis_Homo sapiens_hsa051311.34215991
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32997306
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26438822
33Apoptosis_Homo sapiens_hsa042101.25030450
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24535022
35TNF signaling pathway_Homo sapiens_hsa046681.23159332
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22388570
37Chemokine signaling pathway_Homo sapiens_hsa040621.20234791
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10627489
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10446361
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10105970
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.09003393
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.08898048
43Hematopoietic cell lineage_Homo sapiens_hsa046401.08829307
44Collecting duct acid secretion_Homo sapiens_hsa049661.05710265
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03470334
46Asthma_Homo sapiens_hsa053101.03365524
47Hepatitis B_Homo sapiens_hsa051611.00817075
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97863275
49Herpes simplex infection_Homo sapiens_hsa051680.97783005
50Hepatitis C_Homo sapiens_hsa051600.95822248
51Amoebiasis_Homo sapiens_hsa051460.93569728
52Graft-versus-host disease_Homo sapiens_hsa053320.92881217
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.90072434
54Sphingolipid metabolism_Homo sapiens_hsa006000.88193626
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83696404
56Pancreatic cancer_Homo sapiens_hsa052120.78774846
57Endocytosis_Homo sapiens_hsa041440.75383765
58Chronic myeloid leukemia_Homo sapiens_hsa052200.74592635
59Platelet activation_Homo sapiens_hsa046110.74419944
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74068698
61African trypanosomiasis_Homo sapiens_hsa051430.73674662
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73488376
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72855619
64Viral myocarditis_Homo sapiens_hsa054160.72600687
65Allograft rejection_Homo sapiens_hsa053300.71870926
66Prion diseases_Homo sapiens_hsa050200.71731333
67Steroid biosynthesis_Homo sapiens_hsa001000.69458627
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69234286
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.67287254
70FoxO signaling pathway_Homo sapiens_hsa040680.66310428
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65079812
72Acute myeloid leukemia_Homo sapiens_hsa052210.64629694
73Renin-angiotensin system_Homo sapiens_hsa046140.61604269
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60549349
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.58508194
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58368015
77Endometrial cancer_Homo sapiens_hsa052130.55502174
78GnRH signaling pathway_Homo sapiens_hsa049120.55360044
79T cell receptor signaling pathway_Homo sapiens_hsa046600.55308623
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.52950757
81Proteoglycans in cancer_Homo sapiens_hsa052050.49163844
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45537351
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44806499
84HIF-1 signaling pathway_Homo sapiens_hsa040660.44468140
85Mineral absorption_Homo sapiens_hsa049780.42598277
86PPAR signaling pathway_Homo sapiens_hsa033200.42573728
87Prolactin signaling pathway_Homo sapiens_hsa049170.41896581
88Choline metabolism in cancer_Homo sapiens_hsa052310.41769216
89Type II diabetes mellitus_Homo sapiens_hsa049300.40845661
90HTLV-I infection_Homo sapiens_hsa051660.40594378
91MAPK signaling pathway_Homo sapiens_hsa040100.39275055
92ErbB signaling pathway_Homo sapiens_hsa040120.39116635
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38079270
94VEGF signaling pathway_Homo sapiens_hsa043700.37761466
95Inositol phosphate metabolism_Homo sapiens_hsa005620.37477765
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37471714
97ABC transporters_Homo sapiens_hsa020100.36474038
98Insulin resistance_Homo sapiens_hsa049310.36257247
99Rap1 signaling pathway_Homo sapiens_hsa040150.33756319
100Prostate cancer_Homo sapiens_hsa052150.33562063
101Renal cell carcinoma_Homo sapiens_hsa052110.32588305
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.32071293
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31740348
104Colorectal cancer_Homo sapiens_hsa052100.31170502
105Estrogen signaling pathway_Homo sapiens_hsa049150.30480869
106Notch signaling pathway_Homo sapiens_hsa043300.29204005
107Vibrio cholerae infection_Homo sapiens_hsa051100.28905129
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27386798
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26932649
110Dorso-ventral axis formation_Homo sapiens_hsa043200.26744194
111Epstein-Barr virus infection_Homo sapiens_hsa051690.26247729
112Histidine metabolism_Homo sapiens_hsa003400.26044387
113Viral carcinogenesis_Homo sapiens_hsa052030.25580536
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24924151
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.24066112
116Primary immunodeficiency_Homo sapiens_hsa053400.22391789
117Small cell lung cancer_Homo sapiens_hsa052220.21448115
118Focal adhesion_Homo sapiens_hsa045100.20211706
119Non-small cell lung cancer_Homo sapiens_hsa052230.20085583
120mTOR signaling pathway_Homo sapiens_hsa041500.19395774
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18822690

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