TLR9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.64050506
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.64050506
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.64050506
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.64050506
5modulation by symbiont of host immune response (GO:0052553)6.64050506
6positive regulation by symbiont of host defense response (GO:0052509)6.64050506
7antigen processing and presentation of endogenous antigen (GO:0019883)6.15803938
8B cell receptor signaling pathway (GO:0050853)5.56873469
9regulation of B cell receptor signaling pathway (GO:0050855)5.52011443
10macrophage activation involved in immune response (GO:0002281)5.47720317
11positive regulation of gamma-delta T cell activation (GO:0046645)5.39342898
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.09570635
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.09570635
14detection of other organism (GO:0098543)5.06518044
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.96838658
16detection of bacterium (GO:0016045)4.92462712
17* regulation of interferon-beta biosynthetic process (GO:0045357)4.91274072
18positive regulation of B cell differentiation (GO:0045579)4.69425544
19immunoglobulin mediated immune response (GO:0016064)4.67369383
20positive regulation of antigen processing and presentation (GO:0002579)4.43063007
21microglial cell activation (GO:0001774)4.41687002
22regulation of B cell differentiation (GO:0045577)4.40096468
23regulation of dendritic cell antigen processing and presentation (GO:0002604)4.37106006
24detection of external biotic stimulus (GO:0098581)4.34519982
25response to interleukin-15 (GO:0070672)4.34433505
26negative regulation of lymphocyte mediated immunity (GO:0002707)4.29338430
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.22795276
28response to host immune response (GO:0052572)4.22795276
29detection of molecule of bacterial origin (GO:0032490)4.15750007
30mature B cell differentiation (GO:0002335)4.15392051
31* positive regulation of interferon-alpha production (GO:0032727)4.15115855
32response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.03266922
33response to host (GO:0075136)4.03266922
34response to host defenses (GO:0052200)4.03266922
35cellular response to interleukin-15 (GO:0071350)3.99133306
36* regulation of interferon-alpha production (GO:0032647)3.97623413
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.84393902
38negative regulation of granulocyte differentiation (GO:0030853)3.79003924
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.76674922
40respiratory burst (GO:0045730)3.76076961
41detection of biotic stimulus (GO:0009595)3.75682375
42interferon-gamma-mediated signaling pathway (GO:0060333)3.75022507
43regulation of gamma-delta T cell activation (GO:0046643)3.74886141
44negative regulation of leukocyte mediated immunity (GO:0002704)3.74326641
45production of molecular mediator involved in inflammatory response (GO:0002532)3.72940009
46regulation of antigen processing and presentation (GO:0002577)3.72522514
47regulation of gamma-delta T cell differentiation (GO:0045586)3.70115418
48neutrophil activation involved in immune response (GO:0002283)3.69066775
49tolerance induction (GO:0002507)3.67783034
50leukocyte migration involved in inflammatory response (GO:0002523)3.64613145
51neutrophil mediated immunity (GO:0002446)3.63031059
52neutrophil activation (GO:0042119)3.62963857
53macrophage activation (GO:0042116)3.61818330
54negative regulation of B cell proliferation (GO:0030889)3.57130242
55* positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56949598
56response to muramyl dipeptide (GO:0032495)3.54838214
57germinal center formation (GO:0002467)3.52020454
58negative regulation of T cell mediated immunity (GO:0002710)3.49109414
59myeloid dendritic cell differentiation (GO:0043011)3.48410277
60response to peptidoglycan (GO:0032494)3.47093032
61NIK/NF-kappaB signaling (GO:0038061)3.43430237
62granulocyte activation (GO:0036230)3.43362327
63B cell homeostasis (GO:0001782)3.41278117
64regulation of T-helper 2 cell differentiation (GO:0045628)3.40606190
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38345865
66negative regulation of cell killing (GO:0031342)3.38345865
67negative thymic T cell selection (GO:0045060)3.37032337
68positive thymic T cell selection (GO:0045059)3.35693153
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34949176
70defense response to protozoan (GO:0042832)3.34775819
71B cell proliferation (GO:0042100)3.34416897
72myeloid dendritic cell activation (GO:0001773)3.32797209
73negative regulation of phagocytosis (GO:0050765)3.31548302
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.31369899
75negative regulation of T-helper cell differentiation (GO:0045623)3.31369899
76B cell mediated immunity (GO:0019724)3.30897568
77myeloid cell activation involved in immune response (GO:0002275)3.28508225
78cellular extravasation (GO:0045123)3.28488730
79negative regulation of erythrocyte differentiation (GO:0045647)3.28233945
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27578184
81JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.26847126
82negative T cell selection (GO:0043383)3.25351684
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25123730
84response to type I interferon (GO:0034340)3.24244648
85cellular response to zinc ion (GO:0071294)3.23772200
86antigen processing and presentation via MHC class Ib (GO:0002475)3.21727969
87negative regulation of interleukin-12 production (GO:0032695)3.18904203
88type I interferon signaling pathway (GO:0060337)3.18897359
89cellular response to type I interferon (GO:0071357)3.18897359
90regulation of mast cell degranulation (GO:0043304)3.17088198
91regulation of leukocyte degranulation (GO:0043300)3.16976782
92regulation of B cell proliferation (GO:0030888)3.15373401
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.13029835
94regulation of T cell tolerance induction (GO:0002664)3.12063491
95negative regulation of type 2 immune response (GO:0002829)3.11277747
96leukocyte degranulation (GO:0043299)3.11239702
97leukocyte aggregation (GO:0070486)3.10922327
98positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.09459148
99T cell selection (GO:0045058)3.07247251
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06598503
101lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06571072
102positive T cell selection (GO:0043368)3.06550056
103regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.05130400
104negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.04674544
105myeloid leukocyte mediated immunity (GO:0002444)3.04080597
106negative regulation of bone resorption (GO:0045779)3.01994256
107mature B cell differentiation involved in immune response (GO:0002313)3.01912735
108thymic T cell selection (GO:0045061)3.01348265
109* positive regulation of interferon-beta production (GO:0032728)3.00447633
110regulation of mast cell activation involved in immune response (GO:0033006)2.99272782
111* positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.98400604
112response to protozoan (GO:0001562)2.96035626
113regulation of tolerance induction (GO:0002643)2.95525977
114negative regulation of alpha-beta T cell activation (GO:0046636)2.93980081
115positive regulation of mast cell degranulation (GO:0043306)2.93377424
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.93377424
117regulation of alpha-beta T cell proliferation (GO:0046640)2.91753367
118T cell homeostasis (GO:0043029)2.91634579
119response to laminar fluid shear stress (GO:0034616)2.90626098
120T cell migration (GO:0072678)2.89998674
121positive regulation of histone deacetylation (GO:0031065)2.86286448
122dendritic cell differentiation (GO:0097028)2.85924580
123regulation of superoxide anion generation (GO:0032928)2.85007737
124myeloid leukocyte activation (GO:0002274)2.83787576
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82105627
126lymphocyte homeostasis (GO:0002260)2.81585493
127regulation of mast cell activation (GO:0033003)2.81066906
128cellular response to exogenous dsRNA (GO:0071360)2.80462261
129adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.79322252
130antigen receptor-mediated signaling pathway (GO:0050851)2.79075467
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.78728596
132regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76410004
133positive regulation of B cell activation (GO:0050871)2.76385813
134regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.76055426
135positive regulation of B cell proliferation (GO:0030890)2.74616843
136regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.73439823
137regulation of B cell apoptotic process (GO:0002902)2.71674961
138positive regulation of mast cell activation (GO:0033005)2.70991785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.45323002
2* IRF8_21731497_ChIP-ChIP_J774_Mouse5.30718541
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.22539176
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.09580479
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.83998706
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.80410778
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.68398821
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.59510493
9* MYC_22102868_ChIP-Seq_BL_Human3.43547023
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40448059
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.20701697
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20402598
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15567666
14VDR_21846776_ChIP-Seq_THP-1_Human3.03503190
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90852081
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65299887
17RUNX_20019798_ChIP-Seq_JUKART_Human2.54322954
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54037389
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51927712
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.51694446
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.47929612
22SCL_19346495_ChIP-Seq_HPC-7_Human2.43828152
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43712840
24MAF_26560356_Chip-Seq_TH1_Human2.42508788
25VDR_24763502_ChIP-Seq_THP-1_Human2.42473429
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.38572002
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35838479
28TCF7_22412390_ChIP-Seq_EML_Mouse2.26088559
29SPI1_23127762_ChIP-Seq_K562_Human2.24648672
30MYB_26560356_Chip-Seq_TH2_Human2.23165273
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.20650895
32MYB_26560356_Chip-Seq_TH1_Human2.10701546
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09092854
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08683889
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08583876
36* SPI1_23547873_ChIP-Seq_NB4_Human2.06058799
37KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03231429
38UTX_26944678_Chip-Seq_JUKART_Human1.97270221
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90561070
40KDM2B_26808549_Chip-Seq_DND41_Human1.89079026
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.86960329
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82964191
43NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.75225029
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69582354
45GATA1_22025678_ChIP-Seq_K562_Human1.63920748
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62972965
47* ELK3_25401928_ChIP-Seq_HUVEC_Human1.60716258
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58082288
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54141619
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54069848
51PU_27001747_Chip-Seq_BMDM_Mouse1.51551190
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50980835
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50961797
54VDR_24787735_ChIP-Seq_THP-1_Human1.48513992
55MAF_26560356_Chip-Seq_TH2_Human1.45437092
56* GATA3_27048872_Chip-Seq_THYMUS_Human1.39727874
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35893195
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33180501
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32590543
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.26581180
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26464770
62* BCL6_27268052_Chip-Seq_Bcells_Human1.23630928
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22252759
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21814844
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.18678956
66* BCOR_27268052_Chip-Seq_Bcells_Human1.18221046
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15001960
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12863410
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09792299
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08388800
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08129360
72LXR_22292898_ChIP-Seq_THP-1_Human1.07755443
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.07616833
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06144508
75GATA3_26560356_Chip-Seq_TH2_Human1.04168852
76RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03370854
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.02372932
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01400352
79GATA1_19941826_ChIP-Seq_K562_Human0.99044105
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98381965
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.96693503
82GATA2_19941826_ChIP-Seq_K562_Human0.95130957
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95090095
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94554276
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94379664
86* P68_20966046_ChIP-Seq_HELA_Human0.93926220
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93396953
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91991869
89RACK7_27058665_Chip-Seq_MCF-7_Human0.91830187
90* SA1_27219007_Chip-Seq_ERYTHROID_Human0.91165623
91CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89770621
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88997720
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88343835
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.87954838
95* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87410763
96NCOR1_26117541_ChIP-Seq_K562_Human0.87165078
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86688335
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85847820
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85795135
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84828675
101CIITA_25753668_ChIP-Seq_RAJI_Human0.84333020
102SMRT_27268052_Chip-Seq_Bcells_Human0.83998077
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80109484
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79892767
105* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78490854
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78392889
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75259561
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.73591183
109* SPI1_20517297_ChIP-Seq_HL60_Human0.71956137
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71675316
111* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70995085
112FOXM1_23109430_ChIP-Seq_U2OS_Human0.70639738
113SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.68409560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.05683177
2MP0003303_peritoneal_inflammation4.27076398
3MP0001800_abnormal_humoral_immune3.83770099
4* MP0001790_abnormal_immune_system3.77042293
5* MP0005387_immune_system_phenotype3.77042293
6MP0000685_abnormal_immune_system3.37374632
7* MP0002452_abnormal_antigen_presenting3.25143681
8MP0005000_abnormal_immune_tolerance3.20064371
9MP0004510_myositis3.03541354
10MP0005671_abnormal_response_to3.03204070
11* MP0002723_abnormal_immune_serum2.85435824
12MP0003436_decreased_susceptibility_to2.73395970
13* MP0002420_abnormal_adaptive_immunity2.65255546
14MP0003300_gastrointestinal_ulcer2.63501458
15* MP0002419_abnormal_innate_immunity2.63481682
16* MP0001819_abnormal_immune_cell2.62769289
17MP0006082_CNS_inflammation2.53954103
18* MP0005025_abnormal_response_to2.36051203
19MP0002148_abnormal_hypersensitivity_rea2.27555922
20* MP0002398_abnormal_bone_marrow2.22421251
21MP0005058_abnormal_lysosome_morphology2.21036801
22MP0009785_altered_susceptibility_to2.18706937
23* MP0000716_abnormal_immune_system2.17693740
24MP0000689_abnormal_spleen_morphology2.04357085
25MP0005464_abnormal_platelet_physiology2.02832584
26MP0002405_respiratory_system_inflammati1.95395234
27MP0001873_stomach_inflammation1.91951178
28MP0003191_abnormal_cellular_cholesterol1.91780944
29MP0005310_abnormal_salivary_gland1.91730524
30MP0002132_abnormal_respiratory_system1.90042783
31MP0003183_abnormal_peptide_metabolism1.88498006
32MP0003172_abnormal_lysosome_physiology1.85119033
33* MP0001845_abnormal_inflammatory_respons1.79802468
34MP0002722_abnormal_immune_system1.76214736
35* MP0002429_abnormal_blood_cell1.75297069
36MP0008260_abnormal_autophagy1.74857272
37MP0002166_altered_tumor_susceptibility1.74047333
38MP0001853_heart_inflammation1.73985583
39MP0004947_skin_inflammation1.72551318
40MP0004381_abnormal_hair_follicle1.62929433
41MP0009278_abnormal_bone_marrow1.57857509
42MP0001533_abnormal_skeleton_physiology1.54258691
43MP0009333_abnormal_splenocyte_physiolog1.53313802
44MP0002396_abnormal_hematopoietic_system1.53050409
45MP0009840_abnormal_foam_cell1.51325825
46* MP0010155_abnormal_intestine_physiology1.44472652
47MP0003763_abnormal_thymus_physiology1.41213581
48MP0008469_abnormal_protein_level1.39726493
49MP0000465_gastrointestinal_hemorrhage1.37966963
50MP0005076_abnormal_cell_differentiation1.37171373
51MP0004808_abnormal_hematopoietic_stem1.30765451
52MP0002277_abnormal_respiratory_mucosa1.26361601
53MP0000569_abnormal_digit_pigmentation1.25458112
54MP0003724_increased_susceptibility_to1.24843008
55MP0001986_abnormal_taste_sensitivity1.23534132
56MP0003045_fibrosis1.22502191
57MP0002006_tumorigenesis1.21345398
58MP0000703_abnormal_thymus_morphology1.16226974
59MP0002138_abnormal_hepatobiliary_system1.14774523
60MP0002254_reproductive_system_inflammat1.13157393
61MP0003091_abnormal_cell_migration1.10466552
62MP0001851_eye_inflammation1.09794477
63MP0002933_joint_inflammation1.09117270
64MP0010352_gastrointestinal_tract_polyps1.07559272
65MP0003075_altered_response_to1.06888967
66MP0001545_abnormal_hematopoietic_system1.03449901
67MP0005397_hematopoietic_system_phenotyp1.03449901
68MP0003448_altered_tumor_morphology1.03433497
69MP0003690_abnormal_glial_cell1.03360624
70MP0000343_altered_response_to1.02887537
71MP0002998_abnormal_bone_remodeling1.02489618
72MP0008961_abnormal_basal_metabolism1.01676417
73MP0005075_abnormal_melanosome_morpholog1.01047390
74MP0003566_abnormal_cell_adhesion1.00664177
75MP0000604_amyloidosis0.97321827
76MP0003866_abnormal_defecation0.97238625
77MP0005166_decreased_susceptibility_to0.95347034
78MP0000767_abnormal_smooth_muscle0.93148252
79MP0002928_abnormal_bile_duct0.93058188
80MP0003828_pulmonary_edema0.87720864
81MP0010307_abnormal_tumor_latency0.87564810
82MP0008004_abnormal_stomach_pH0.86950618
83MP0002136_abnormal_kidney_physiology0.85781806
84MP0000249_abnormal_blood_vessel0.81032973
85MP0003453_abnormal_keratinocyte_physiol0.80265792
86MP0005174_abnormal_tail_pigmentation0.79747634
87MP0009764_decreased_sensitivity_to0.76562583
88MP0005164_abnormal_response_to0.72823485
89MP0005023_abnormal_wound_healing0.72278881
90MP0003221_abnormal_cardiomyocyte_apopto0.70824181
91MP0000490_abnormal_crypts_of0.68769724
92MP0001663_abnormal_digestive_system0.68375981
93MP0005390_skeleton_phenotype0.65315953
94MP0000609_abnormal_liver_physiology0.59664239
95MP0000858_altered_metastatic_potential0.59317738
96MP0002009_preneoplasia0.58896552
97MP0004130_abnormal_muscle_cell0.57620480
98MP0005670_abnormal_white_adipose0.57147931
99MP0009763_increased_sensitivity_to0.56714860
100MP0002019_abnormal_tumor_incidence0.56449102
101MP0002332_abnormal_exercise_endurance0.55700055
102MP0001915_intracranial_hemorrhage0.55099676
103MP0009765_abnormal_xenobiotic_induced0.54525718
104MP0004883_abnormal_blood_vessel0.54221180
105MP0008874_decreased_physiological_sensi0.54015825
106MP0005451_abnormal_body_composition0.53347489
107MP0005257_abnormal_intraocular_pressure0.52700986
108MP0000015_abnormal_ear_pigmentation0.52479146
109MP0004185_abnormal_adipocyte_glucose0.52212651
110MP0003795_abnormal_bone_structure0.51102528
111MP0005621_abnormal_cell_physiology0.50011637
112MP0002168_other_aberrant_phenotype0.49969221
113MP0002693_abnormal_pancreas_physiology0.49514666
114MP0003656_abnormal_erythrocyte_physiolo0.49131648
115MP0000371_diluted_coat_color0.48674821
116MP0008873_increased_physiological_sensi0.48156246
117MP0003878_abnormal_ear_physiology0.44321776
118MP0005377_hearing/vestibular/ear_phenot0.44321776
119MP0005381_digestive/alimentary_phenotyp0.44219212
120MP0000313_abnormal_cell_death0.42046213

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.69294294
2Recurrent abscess formation (HP:0002722)5.54367800
3Recurrent bacterial skin infections (HP:0005406)5.39449500
4Colitis (HP:0002583)5.22271718
5Cellulitis (HP:0100658)4.82083295
6Eczematoid dermatitis (HP:0000976)4.69289993
7Gastrointestinal stroma tumor (HP:0100723)4.61591265
8Inflammation of the large intestine (HP:0002037)4.58355593
9Systemic lupus erythematosus (HP:0002725)4.48406640
10Gastrointestinal inflammation (HP:0004386)4.36902985
11Recurrent viral infections (HP:0004429)4.36398041
12Gastrointestinal infarctions (HP:0005244)4.10130715
13Hypochromic microcytic anemia (HP:0004840)4.08122129
14Recurrent bronchitis (HP:0002837)3.97898935
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.97449975
16Recurrent fungal infections (HP:0002841)3.88273839
17Chronic otitis media (HP:0000389)3.87653273
18Recurrent skin infections (HP:0001581)3.83953122
19IgM deficiency (HP:0002850)3.80533433
20Meningitis (HP:0001287)3.74836052
21Vasculitis (HP:0002633)3.69679885
22Mediastinal lymphadenopathy (HP:0100721)3.61802202
23Hypochromic anemia (HP:0001931)3.55973303
24Keratoconjunctivitis sicca (HP:0001097)3.54340685
25Recurrent cutaneous fungal infections (HP:0011370)3.51924844
26Chronic mucocutaneous candidiasis (HP:0002728)3.51924844
27Verrucae (HP:0200043)3.47969244
28Papilloma (HP:0012740)3.47969244
29Recurrent gram-negative bacterial infections (HP:0005420)3.46251221
30Glomerulonephritis (HP:0000099)3.45562005
31Emphysema (HP:0002097)3.44201903
32Hematochezia (HP:0002573)3.34001747
33Panhypogammaglobulinemia (HP:0003139)3.33542399
34Recurrent sinusitis (HP:0011108)3.33361326
35Prolonged bleeding time (HP:0003010)3.27186365
36Keratoconjunctivitis (HP:0001096)3.26715093
37Autoimmune thrombocytopenia (HP:0001973)3.21975800
38Abnormality of macrophages (HP:0004311)3.19817265
39Osteomyelitis (HP:0002754)3.16152495
40Increased cerebral lipofuscin (HP:0011813)3.14124374
41Lymphopenia (HP:0001888)3.13965683
42Abnormality of liposaccharide metabolism (HP:0010968)3.13469274
43Abnormality of glycosphingolipid metabolism (HP:0004343)3.13469274
44Abnormality of glycolipid metabolism (HP:0010969)3.13469274
45Myositis (HP:0100614)3.11547078
46Spontaneous hematomas (HP:0007420)3.08256823
47Chronic obstructive pulmonary disease (HP:0006510)3.02172858
48Obstructive lung disease (HP:0006536)3.02172858
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.98449107
50Chronic sinusitis (HP:0011109)2.92229968
51Recurrent pneumonia (HP:0006532)2.88582871
52Interstitial pulmonary disease (HP:0006530)2.88561074
53Episodic fever (HP:0001954)2.87148845
54Elevated erythrocyte sedimentation rate (HP:0003565)2.83302598
55Dysostosis multiplex (HP:0000943)2.82157184
56Recurrent lower respiratory tract infections (HP:0002783)2.81555778
57Hemoptysis (HP:0002105)2.80597317
58Pustule (HP:0200039)2.78088110
59Restrictive lung disease (HP:0002091)2.74082302
60Nasal polyposis (HP:0100582)2.70346416
61Gingival bleeding (HP:0000225)2.66339045
62T lymphocytopenia (HP:0005403)2.64905017
63Abnormality of the fingertips (HP:0001211)2.60305836
64Periodontitis (HP:0000704)2.59818729
65Epistaxis (HP:0000421)2.59508689
66Increased IgE level (HP:0003212)2.59197070
67Orchitis (HP:0100796)2.57640282
68Increased IgM level (HP:0003496)2.56864610
69Pulmonary infiltrates (HP:0002113)2.56202394
70Abnormality of the peritoneum (HP:0002585)2.55534589
71Gingivitis (HP:0000230)2.55165763
72Abnormality of T cell number (HP:0011839)2.53754054
73Granulocytopenia (HP:0001913)2.52566500
74Anorexia (HP:0002039)2.52326907
75Chronic diarrhea (HP:0002028)2.51263741
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.50249630
77Pulmonary embolism (HP:0002204)2.50160902
78Mitral stenosis (HP:0001718)2.47606025
79Leukocytosis (HP:0001974)2.45330940
80Abnormality of the pleura (HP:0002103)2.44771308
81Abnormality of the nasal mucosa (HP:0000433)2.44335694
82Microcytic anemia (HP:0001935)2.42734829
83Complement deficiency (HP:0004431)2.41972124
84Optic neuritis (HP:0100653)2.40813427
85Retrobulbar optic neuritis (HP:0100654)2.40813427
86Sepsis (HP:0100806)2.40728822
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37423490
88Cerebral aneurysm (HP:0004944)2.36762230
89Myocardial infarction (HP:0001658)2.36707564
90Petechiae (HP:0000967)2.34738612
91IgA deficiency (HP:0002720)2.33988089
92Thyroiditis (HP:0100646)2.28830830
93Peritonitis (HP:0002586)2.27750806
94Loss of speech (HP:0002371)2.26530123
95Hypergammaglobulinemia (HP:0010702)2.24180577
96Disinhibition (HP:0000734)2.24045760
97Fatigue (HP:0012378)2.22455646
98Arterial thrombosis (HP:0004420)2.21266815
99Stomatitis (HP:0010280)2.19739519
100Mucopolysacchariduria (HP:0008155)2.18622728
101Urinary glycosaminoglycan excretion (HP:0003541)2.18622728
102Encephalitis (HP:0002383)2.17534422
103Skin rash (HP:0000988)2.16113650
104Skin ulcer (HP:0200042)2.14708140
105Abnormality of the endocardium (HP:0004306)2.13579544
106Abnormality of T cell physiology (HP:0011840)2.13218416
107Gangrene (HP:0100758)2.13208351
108Chest pain (HP:0100749)2.11121722
109Bronchitis (HP:0012387)2.10357024
110Viral hepatitis (HP:0006562)2.09820965
111Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09586331
112Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09586331
113Abnormality of polysaccharide metabolism (HP:0011012)2.09586331
114Leukopenia (HP:0001882)2.08980760
115Abnormality of complement system (HP:0005339)2.08542974
116Vacuolated lymphocytes (HP:0001922)2.07110665
117Osteolytic defects of the phalanges of the hand (HP:0009771)2.05936440
118Osteolytic defects of the hand bones (HP:0009699)2.05936440
119Urticaria (HP:0001025)2.03889382
120Slow saccadic eye movements (HP:0000514)2.03216724
121Acute hepatic failure (HP:0006554)1.99490348
122Arterial tortuosity (HP:0005116)1.99081480
123Increased density of long bones (HP:0006392)1.98960065
124Arthralgia (HP:0002829)1.98779685
125Hepatosplenomegaly (HP:0001433)1.98581970
126Abnormality of T cells (HP:0002843)1.97113858
127Lymphoma (HP:0002665)1.95470673
128Nephritis (HP:0000123)1.95131624
129Eosinophilia (HP:0001880)1.94113347
130Thrombocytosis (HP:0001894)1.93750614
131Glomerulopathy (HP:0100820)1.93639017
132Axonal loss (HP:0003447)1.93398251
133Purpura (HP:0000979)1.91064470
134Premature loss of primary teeth (HP:0006323)1.88404173
135Keratitis (HP:0000491)1.87285846
136Hypermelanotic macule (HP:0001034)1.85898560
137Amyloidosis (HP:0011034)1.82845179
138Abnormality of the pericardium (HP:0001697)1.81197794
139Abnormal platelet volume (HP:0011876)1.80973902
140Metaphyseal cupping (HP:0003021)1.76866642
141Difficulty running (HP:0009046)1.74932135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.48576289
2ERN13.32912626
3CSF1R3.16533882
4TYK23.13464384
5BLK2.92418903
6TGFBR22.86590755
7RIPK42.65367872
8MAP3K142.62402772
9PRPF4B2.56099373
10TBK12.46942366
11JAK12.33779351
12MAP3K102.28791285
13STK102.21663637
14GRK62.11443144
15MAP3K132.10161795
16SYK1.97468801
17IRAK41.96443045
18IRAK31.94308460
19CDK121.88820912
20BTK1.84649196
21KIT1.83201229
22SIK21.79792457
23IKBKB1.79130196
24EPHB11.73531556
25CSK1.64434119
26HCK1.63058656
27JAK31.56296454
28IKBKE1.53810321
29MAP3K111.53788584
30LRRK21.49192598
31SMG11.49048307
32FES1.45409228
33MAP3K31.44235713
34CAMK1D1.42928700
35EEF2K1.40478594
36CLK11.34455333
37ZAP701.29067369
38LYN1.26834938
39CAMK1G1.25685557
40MARK31.20746713
41CHUK1.18585356
42MAP3K11.12658528
43MARK21.12637279
44MATK1.08375551
45PIM11.07205619
46ITK1.04031959
47LCK1.03020617
48FGR1.00638035
49SIK31.00176162
50TRIB30.96447900
51YES10.94753626
52FGFR40.93030397
53FGFR30.89567944
54IRAK20.89407084
55JAK20.88343509
56TAOK20.88203208
57PTK60.86068182
58TESK20.84278748
59IRAK10.81735201
60TAOK30.81557399
61ALK0.81044083
62RPS6KA40.80262205
63MAPK150.79494160
64CDK190.78530829
65MAP2K30.75263244
66BMPR20.73412160
67MAP3K90.71648355
68TEC0.70947061
69SIK10.66056993
70GRK70.65298966
71BRD40.64993516
72EPHA30.63961500
73HIPK20.61822279
74MAPK120.60933308
75TNK20.59545340
76PKN20.59202518
77ABL10.57388061
78RAF10.56482233
79EGFR0.56440669
80PRKCQ0.55620047
81MAPK70.55608212
82PIK3CG0.54847617
83PDK10.53402286
84PAK40.53040025
85DYRK1B0.52380748
86BMX0.51543989
87MAPK110.48400509
88MST40.47652256
89TSSK60.45547468
90MAP3K60.44304450
91CDK90.44213552
92RPS6KL10.43220652
93RPS6KC10.43220652
94CDK60.41928624
95MAP2K40.41144236
96SGK30.41067332
97MAP3K80.40673933
98KSR20.40375680
99STK110.39431345
100CDC42BPA0.39298312
101INSR0.38859843
102MAPKAPK20.38837435
103NEK90.38313680
104MAP3K50.37945675
105CAMKK10.37247864
106PRKAA20.37030148
107RET0.36809956
108CDK40.36706781
109MAP2K60.36351994
110PKN10.36332900
111MAP3K20.36043081
112STK40.35633128
113RPS6KA60.35583086
114NLK0.35462426
115MAPK40.35269082
116SCYL20.34763929
117FYN0.34126690
118TAOK10.33396774
119PRKD20.33163805
120PRKD10.32932650
121PRKCH0.32438094
122GRK10.32172332
123PRKCD0.31868164
124TXK0.31337049
125PTK2B0.31042320
126STK380.30969825
127MAP3K70.29555529
128PRKCZ0.29519591
129PDPK10.28516244
130MELK0.28089394
131TTN0.27827686

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046624.20776858
2Primary immunodeficiency_Homo sapiens_hsa053403.01217035
3Osteoclast differentiation_Homo sapiens_hsa043802.97176376
4Leishmaniasis_Homo sapiens_hsa051402.89927561
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.62721762
6Staphylococcus aureus infection_Homo sapiens_hsa051502.51209684
7Antigen processing and presentation_Homo sapiens_hsa046122.35569065
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.25004169
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.23905336
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.15766882
11* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15412579
12Hematopoietic cell lineage_Homo sapiens_hsa046402.01264390
13Type I diabetes mellitus_Homo sapiens_hsa049401.92422922
14* Tuberculosis_Homo sapiens_hsa051521.81489775
15Toxoplasmosis_Homo sapiens_hsa051451.77476075
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75936220
17Pertussis_Homo sapiens_hsa051331.75360158
18* Measles_Homo sapiens_hsa051621.73616050
19Chemokine signaling pathway_Homo sapiens_hsa040621.67814144
20Other glycan degradation_Homo sapiens_hsa005111.63221071
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62972983
22Influenza A_Homo sapiens_hsa051641.62464021
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58499339
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53440968
25Lysosome_Homo sapiens_hsa041421.52020356
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51476100
27* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46578434
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45748231
29T cell receptor signaling pathway_Homo sapiens_hsa046601.44730487
30Chronic myeloid leukemia_Homo sapiens_hsa052201.40157503
31TNF signaling pathway_Homo sapiens_hsa046681.35508939
32Apoptosis_Homo sapiens_hsa042101.34859109
33* Herpes simplex infection_Homo sapiens_hsa051681.34166540
34Shigellosis_Homo sapiens_hsa051311.33912788
35Legionellosis_Homo sapiens_hsa051341.33366323
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.30683711
37Hepatitis B_Homo sapiens_hsa051611.30582190
38Acute myeloid leukemia_Homo sapiens_hsa052211.27776130
39Pancreatic cancer_Homo sapiens_hsa052121.24566114
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.22319242
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.15741800
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15043337
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08695295
44Allograft rejection_Homo sapiens_hsa053301.08127200
45* Malaria_Homo sapiens_hsa051441.06872741
46Epstein-Barr virus infection_Homo sapiens_hsa051691.03756175
47Platelet activation_Homo sapiens_hsa046111.02251277
48Salmonella infection_Homo sapiens_hsa051320.99618075
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99458094
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98656405
51Hepatitis C_Homo sapiens_hsa051600.98620612
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93667363
53Viral myocarditis_Homo sapiens_hsa054160.93122026
54Non-small cell lung cancer_Homo sapiens_hsa052230.89299171
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88799513
56Notch signaling pathway_Homo sapiens_hsa043300.88306729
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87614157
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87304935
59Graft-versus-host disease_Homo sapiens_hsa053320.83004467
60VEGF signaling pathway_Homo sapiens_hsa043700.81289728
61Renal cell carcinoma_Homo sapiens_hsa052110.77369798
62Prolactin signaling pathway_Homo sapiens_hsa049170.75458122
63Viral carcinogenesis_Homo sapiens_hsa052030.73784287
64Endometrial cancer_Homo sapiens_hsa052130.73747278
65Rheumatoid arthritis_Homo sapiens_hsa053230.72037287
66Endocytosis_Homo sapiens_hsa041440.71791778
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70559074
68MAPK signaling pathway_Homo sapiens_hsa040100.68707839
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68527039
70Choline metabolism in cancer_Homo sapiens_hsa052310.68402481
71Dorso-ventral axis formation_Homo sapiens_hsa043200.66767895
72Colorectal cancer_Homo sapiens_hsa052100.65461339
73Small cell lung cancer_Homo sapiens_hsa052220.64750808
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64321723
75HTLV-I infection_Homo sapiens_hsa051660.61925954
76Type II diabetes mellitus_Homo sapiens_hsa049300.59634844
77Insulin resistance_Homo sapiens_hsa049310.59081458
78GnRH signaling pathway_Homo sapiens_hsa049120.58983058
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58793582
80Prion diseases_Homo sapiens_hsa050200.58350660
81Phagosome_Homo sapiens_hsa041450.58020519
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57963965
83FoxO signaling pathway_Homo sapiens_hsa040680.57418090
84Asthma_Homo sapiens_hsa053100.56183664
85MicroRNAs in cancer_Homo sapiens_hsa052060.55325741
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.54881734
87mTOR signaling pathway_Homo sapiens_hsa041500.53832339
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51982449
89Glioma_Homo sapiens_hsa052140.50955143
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.50950713
91HIF-1 signaling pathway_Homo sapiens_hsa040660.50846649
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50323758
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49222972
94Complement and coagulation cascades_Homo sapiens_hsa046100.48443454
95Proteoglycans in cancer_Homo sapiens_hsa052050.47863224
96Amoebiasis_Homo sapiens_hsa051460.47761645
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46956891
98ErbB signaling pathway_Homo sapiens_hsa040120.46473188
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46170913
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45069741
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.44862788
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.44345283
103Inositol phosphate metabolism_Homo sapiens_hsa005620.42352159
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40255963
105Insulin signaling pathway_Homo sapiens_hsa049100.39660317
106Rap1 signaling pathway_Homo sapiens_hsa040150.39186186
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37767020
108* African trypanosomiasis_Homo sapiens_hsa051430.37140372
109Estrogen signaling pathway_Homo sapiens_hsa049150.36416733
110Caffeine metabolism_Homo sapiens_hsa002320.36357996
111Lysine degradation_Homo sapiens_hsa003100.34438677
112Prostate cancer_Homo sapiens_hsa052150.34267785
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33601979
114Adherens junction_Homo sapiens_hsa045200.32835676
115Autoimmune thyroid disease_Homo sapiens_hsa053200.31560236
116ABC transporters_Homo sapiens_hsa020100.31418159

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