TLX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron fate determination (GO:0048664)8.51801968
2proline biosynthetic process (GO:0006561)7.89594302
3establishment of apical/basal cell polarity (GO:0035089)6.40039691
4embryonic process involved in female pregnancy (GO:0060136)6.03911383
5replication fork processing (GO:0031297)5.83047200
6regulation of integrin activation (GO:0033623)5.70994769
7proline metabolic process (GO:0006560)5.70657462
8establishment or maintenance of monopolar cell polarity (GO:0061339)5.47641946
9establishment of monopolar cell polarity (GO:0061162)5.47641946
10positive regulation of protein homooligomerization (GO:0032464)5.42674906
11transcription from mitochondrial promoter (GO:0006390)5.34970541
12lymph vessel development (GO:0001945)4.77480455
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.76699990
14oxidative demethylation (GO:0070989)4.66291975
15DNA strand renaturation (GO:0000733)4.63786382
16regulation of transcription involved in cell fate commitment (GO:0060850)4.59519765
17spliceosomal tri-snRNP complex assembly (GO:0000244)4.49697420
18convergent extension (GO:0060026)4.45179124
19mitotic G1 DNA damage checkpoint (GO:0031571)4.44081977
20regulation of fatty acid beta-oxidation (GO:0031998)4.42877111
21poly(A)+ mRNA export from nucleus (GO:0016973)4.42032507
22negative regulation of nitric-oxide synthase activity (GO:0051001)4.41046709
23spinal cord motor neuron differentiation (GO:0021522)4.39129532
24regulation of protein homooligomerization (GO:0032462)4.36901931
25negative regulation of catecholamine secretion (GO:0033604)4.30969669
26cranial nerve morphogenesis (GO:0021602)4.24375647
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.17973171
28DNA replication checkpoint (GO:0000076)4.15577517
29negative regulation of JAK-STAT cascade (GO:0046426)4.14779473
30face development (GO:0060324)4.12661318
31regulation of penile erection (GO:0060405)4.09278899
32G1 DNA damage checkpoint (GO:0044783)4.09045022
33regulation of mammary gland epithelial cell proliferation (GO:0033599)4.08543145
34mitochondrial DNA metabolic process (GO:0032042)4.04975346
35somatic hypermutation of immunoglobulin genes (GO:0016446)4.04301763
36somatic diversification of immune receptors via somatic mutation (GO:0002566)4.04301763
37negative regulation of Ras GTPase activity (GO:0034261)4.00447534
38DNA replication initiation (GO:0006270)3.97073162
39DNA deamination (GO:0045006)3.96407894
40pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.93401862
41peptidyl-arginine omega-N-methylation (GO:0035247)3.90303121
42mitotic G1/S transition checkpoint (GO:0044819)3.90260128
43DNA integration (GO:0015074)3.87199965
44embryonic skeletal joint morphogenesis (GO:0060272)3.83571470
45negative regulation of cAMP-mediated signaling (GO:0043951)3.79852414
46regulation of fever generation (GO:0031620)3.75779648
47negative regulation of mRNA processing (GO:0050686)3.75649550
48regulation of translational fidelity (GO:0006450)3.75197766
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.75036064
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.75036064
51positive regulation of mitotic sister chromatid separation (GO:1901970)3.75036064
52pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.74092132
53embryonic placenta development (GO:0001892)3.73301699
54regulation of sister chromatid cohesion (GO:0007063)3.71246891
55UTP biosynthetic process (GO:0006228)3.70927591
56proximal/distal pattern formation (GO:0009954)3.67403072
57muscle cell fate commitment (GO:0042693)3.67012852
58paraxial mesoderm development (GO:0048339)3.65372980
59formation of translation preinitiation complex (GO:0001731)3.64240496
60guanosine-containing compound biosynthetic process (GO:1901070)3.61358171
61regulation of cardioblast differentiation (GO:0051890)3.58636250
62regulation of posttranscriptional gene silencing (GO:0060147)3.56582747
63regulation of gene silencing by miRNA (GO:0060964)3.56582747
64regulation of gene silencing by RNA (GO:0060966)3.56582747
65negative regulation of cell cycle arrest (GO:0071157)3.56381947
66CTP metabolic process (GO:0046036)3.55743236
67CTP biosynthetic process (GO:0006241)3.55743236
68embryonic camera-type eye development (GO:0031076)3.54708261
69positive regulation of heat generation (GO:0031652)3.54694451
70morphogenesis of an epithelial fold (GO:0060571)3.51838435
71pre-miRNA processing (GO:0031054)3.51544495
72heterochromatin organization (GO:0070828)3.50468859
73viral mRNA export from host cell nucleus (GO:0046784)3.48805382
74pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.47389884
75mRNA cleavage (GO:0006379)3.46334255
76pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.46017013
77embryonic viscerocranium morphogenesis (GO:0048703)3.44745365
78GTP biosynthetic process (GO:0006183)3.44669610
79polarized epithelial cell differentiation (GO:0030859)3.42836264
80apoptotic process involved in morphogenesis (GO:0060561)3.41067540
81DNA topological change (GO:0006265)3.40244792
82outflow tract septum morphogenesis (GO:0003148)3.37999638
83regulation of RNA export from nucleus (GO:0046831)3.37814704
84rRNA transcription (GO:0009303)3.36054499
85UTP metabolic process (GO:0046051)3.34914866
86base-excision repair (GO:0006284)3.34642007
87positive regulation of chromosome segregation (GO:0051984)3.33325107
88negative regulation of chondrocyte differentiation (GO:0032331)3.32150801
89double-strand break repair via nonhomologous end joining (GO:0006303)3.29469627
90non-recombinational repair (GO:0000726)3.29469627
91cellular response to ATP (GO:0071318)3.28156191
92mammary gland epithelial cell differentiation (GO:0060644)3.26861350
93histone arginine methylation (GO:0034969)3.26558681
94GDP-mannose metabolic process (GO:0019673)3.25575416
95regulation of double-strand break repair (GO:2000779)3.24712074
96negative regulation of RNA splicing (GO:0033119)3.24682062
97negative regulation of mast cell activation (GO:0033004)3.24073700
98peptidyl-arginine methylation (GO:0018216)3.24072282
99peptidyl-arginine N-methylation (GO:0035246)3.24072282
100folic acid metabolic process (GO:0046655)3.24068451
101positive regulation of receptor recycling (GO:0001921)3.23285123
102negative regulation of cell fate commitment (GO:0010454)3.22235196
103peripheral nervous system neuron development (GO:0048935)3.20957504
104DNA unwinding involved in DNA replication (GO:0006268)3.19876182
105positive regulation of developmental pigmentation (GO:0048087)3.19668132
106negative regulation of protein oligomerization (GO:0032460)3.14234285
107glial cell migration (GO:0008347)3.14198770
108positive regulation of protein oligomerization (GO:0032461)3.09014042
109pharyngeal system development (GO:0060037)3.08923454
110dosage compensation (GO:0007549)3.06358177
111response to misfolded protein (GO:0051788)3.04347256
112chromatin assembly (GO:0031497)3.03570531
113negative regulation of cartilage development (GO:0061037)3.03376599
114lateral sprouting from an epithelium (GO:0060601)3.03231787
115telomere maintenance via semi-conservative replication (GO:0032201)3.01857579
116labyrinthine layer development (GO:0060711)3.01200719
117anatomical structure regression (GO:0060033)3.00108073
118trophectodermal cell differentiation (GO:0001829)3.00044058
119protein-DNA complex disassembly (GO:0032986)2.99622819
120nucleosome disassembly (GO:0006337)2.99622819
121establishment or maintenance of apical/basal cell polarity (GO:0035088)2.94908628
122establishment or maintenance of bipolar cell polarity (GO:0061245)2.94908628
123thyroid gland development (GO:0030878)2.94836861
124protein insertion into membrane (GO:0051205)2.93783067
125DNA double-strand break processing (GO:0000729)2.93319608
126regulation of DNA damage checkpoint (GO:2000001)2.92969856
127cell differentiation in spinal cord (GO:0021515)2.92343405
128ribosomal small subunit biogenesis (GO:0042274)2.91147898
129regulation of protein oligomerization (GO:0032459)2.90784136
130negative regulation of mRNA metabolic process (GO:1903312)2.90642128
131embryonic heart tube development (GO:0035050)2.90418048
132meiotic chromosome segregation (GO:0045132)2.90390777
133kinetochore assembly (GO:0051382)2.90230527
134regulation of chromatin binding (GO:0035561)2.88894266
135positive regulation by host of viral transcription (GO:0043923)2.87402516
136DNA strand elongation (GO:0022616)2.87373186
137negative regulation of adherens junction organization (GO:1903392)2.86799303
138negative regulation of focal adhesion assembly (GO:0051895)2.86799303
139negative regulation of cell junction assembly (GO:1901889)2.86799303
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.86520869
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85372629
142positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.84744695
143misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.84547352
144cellular response to zinc ion (GO:0071294)2.84501344
145regulation of double-strand break repair via homologous recombination (GO:0010569)2.83913217
146termination of RNA polymerase II transcription (GO:0006369)2.83527147
147DNA ligation (GO:0006266)2.81952858
148DNA strand elongation involved in DNA replication (GO:0006271)2.81891764
149nodal signaling pathway (GO:0038092)2.81494724
150regulation of stem cell maintenance (GO:2000036)2.80531096
151mitotic nuclear envelope reassembly (GO:0007084)2.80458784
152nuclear envelope reassembly (GO:0031468)2.80458784
153tRNA methylation (GO:0030488)2.79861838
154regulation of hippo signaling (GO:0035330)2.79361170
155regulation of action potential (GO:0098900)2.74471689
156embryonic eye morphogenesis (GO:0048048)2.74411172
157peptidyl-histidine modification (GO:0018202)2.73952931
158regulation of mitochondrial translation (GO:0070129)2.73892337
159cochlea morphogenesis (GO:0090103)2.71002624
160glutamine family amino acid biosynthetic process (GO:0009084)2.70878311
161negative regulation of fatty acid metabolic process (GO:0045922)2.69865433
162coronary vasculature morphogenesis (GO:0060977)2.69323344
163basement membrane organization (GO:0071711)2.69128621
164mitotic sister chromatid segregation (GO:0000070)2.68262384
165mitochondrial fusion (GO:0008053)2.68105055
166DNA replication-dependent nucleosome organization (GO:0034723)2.67795116
167DNA replication-dependent nucleosome assembly (GO:0006335)2.67795116
168oxidative phosphorylation (GO:0006119)2.67683066
169head development (GO:0060322)2.67221824
170pseudouridine synthesis (GO:0001522)2.67218016
171spinal cord development (GO:0021510)2.65473314
172tooth mineralization (GO:0034505)2.64833801
173dorsal/ventral neural tube patterning (GO:0021904)2.63354321
174regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.56931774
175glycine metabolic process (GO:0006544)2.53526042
176negative regulation of monooxygenase activity (GO:0032769)2.52724639
177regulation of translational elongation (GO:0006448)2.52675279
178outer ear morphogenesis (GO:0042473)2.52377218
179atrial septum morphogenesis (GO:0060413)2.50930083
180sister chromatid segregation (GO:0000819)2.50516705
181pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.48414895
182intracellular estrogen receptor signaling pathway (GO:0030520)2.48346534
183regulation of cardioblast proliferation (GO:0003264)2.47608870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD1_18555785_ChIP-Seq_MESCs_Mouse4.01423478
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.77243270
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.57685147
4E2F7_22180533_ChIP-Seq_HELA_Human3.51965481
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45774661
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.21855037
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.21855037
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.21855037
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.79768353
10XRN2_22483619_ChIP-Seq_HELA_Human2.66276124
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.64757981
12KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.53692628
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.52005942
14* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.50543460
15VDR_21846776_ChIP-Seq_THP-1_Human2.46574346
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38276577
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23876721
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18240978
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.17865399
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.12349043
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.11933657
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11892379
23* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10447604
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.10140134
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.10118624
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.07783362
27NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.07336803
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.05489662
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05313459
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00444999
31POU5F1_16518401_ChIP-PET_MESCs_Mouse2.00179919
32MYC_22102868_ChIP-Seq_BL_Human1.98874705
33LXR_22292898_ChIP-Seq_THP-1_Human1.97053082
34CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.92923209
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91401027
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90184767
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.89091442
38GABP_19822575_ChIP-Seq_HepG2_Human1.86152427
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84730387
40NANOG_21062744_ChIP-ChIP_HESCs_Human1.84232191
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83322020
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82241402
43CIITA_25753668_ChIP-Seq_RAJI_Human1.80233085
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.79453738
45KDM5A_27292631_Chip-Seq_BREAST_Human1.79092795
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75471443
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75429220
48* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73931381
49TTF2_22483619_ChIP-Seq_HELA_Human1.72567059
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71322837
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70957108
52KDM2B_26808549_Chip-Seq_DND41_Human1.70626733
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.70373378
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.70109348
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68776487
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68677597
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.67572063
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67559640
59* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67393188
60* CBX2_27304074_Chip-Seq_ESCs_Mouse1.63506626
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60533930
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58151866
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.58080370
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57779795
65RACK7_27058665_Chip-Seq_MCF-7_Human1.52262064
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.51094871
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50453458
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48479110
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47957082
70P68_20966046_ChIP-Seq_HELA_Human1.47019636
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45511750
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43593705
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40996854
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40091853
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37792308
76ZNF263_19887448_ChIP-Seq_K562_Human1.37494961
77DCP1A_22483619_ChIP-Seq_HELA_Human1.37348091
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36872173
79* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.36214306
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35811827
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34905217
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34568578
83* EED_16625203_ChIP-ChIP_MESCs_Mouse1.34473844
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33913977
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.32916761
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32270137
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32267578
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31878701
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.30970265
90* EZH2_27304074_Chip-Seq_ESCs_Mouse1.30277378
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30074195
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29244188
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27770982
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26970869
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.24920886
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24400364
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23845693
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.23108941
99KDM2B_26808549_Chip-Seq_K562_Human1.22520411
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22514769
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22114173
102TCF7_22412390_ChIP-Seq_EML_Mouse1.21383239
103E2F1_21310950_ChIP-Seq_MCF-7_Human1.21013610
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.19095657
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17968133
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17712239
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.17072628
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16853983
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16446054
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16441872
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15971091
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15771255
113CREB1_26743006_Chip-Seq_LNCaP_Human1.15439928
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15391611
115* TP53_20018659_ChIP-ChIP_R1E_Mouse1.14822148
116* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14757617
117* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14736456
118MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14300406
119CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14216285
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14047443
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12893181
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12674392
123* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12234917
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11351814
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10667985
126* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10592368
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09500900
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09018849
129* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.08048731
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07291541
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07284125
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06940406
133RARA_24833708_ChIP-Seq_LIVER_Mouse1.06615777
134* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05783363
135* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05783363
136TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05780760
137KDM2B_26808549_Chip-Seq_JURKAT_Human1.05715683
138EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05584641
139CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04750443
140CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04364865
141THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04266463
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03637328
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03312183
144ETS1_21867929_ChIP-Seq_TH2_Mouse1.02779856
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02613444
146MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02605272
147* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02485775
148HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01578065
149ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01000343
150SOX2_16153702_ChIP-ChIP_HESCs_Human1.00701912
151CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00592618
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00467860
153NCOR1_26117541_ChIP-Seq_K562_Human1.00269816
154CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00161172
155* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00096530
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98504406
157TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98218140
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96768843
159E2F1_20622854_ChIP-Seq_HELA_Human0.95777309
160DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93981604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.57152890
2MP0010030_abnormal_orbit_morphology3.80857911
3MP0005171_absent_coat_pigmentation3.32212515
4MP0003122_maternal_imprinting3.24737001
5MP0009278_abnormal_bone_marrow3.18924651
6MP0003283_abnormal_digestive_organ3.04470871
7MP0001346_abnormal_lacrimal_gland2.88665964
8MP0004233_abnormal_muscle_weight2.87103588
9MP0000678_abnormal_parathyroid_gland2.72336469
10MP0003123_paternal_imprinting2.53949180
11MP0003693_abnormal_embryo_hatching2.48492166
12MP0003119_abnormal_digestive_system2.47310299
13MP0005187_abnormal_penis_morphology2.35074463
14MP0003385_abnormal_body_wall2.27746525
15MP0002234_abnormal_pharynx_morphology2.23159273
16MP0003567_abnormal_fetal_cardiomyocyte2.16193674
17MP0002249_abnormal_larynx_morphology2.16135378
18MP0002282_abnormal_trachea_morphology2.15224549
19MP0004185_abnormal_adipocyte_glucose2.12625635
20MP0005451_abnormal_body_composition2.11483695
21MP0002735_abnormal_chemical_nociception2.07477783
22MP0005167_abnormal_blood-brain_barrier2.05168121
23MP0002822_catalepsy10.4137726
24MP0004197_abnormal_fetal_growth/weight/1.99844065
25MP0003121_genomic_imprinting1.98701398
26MP0010094_abnormal_chromosome_stability1.92320578
27MP0002086_abnormal_extraembryonic_tissu1.89720421
28MP0002084_abnormal_developmental_patter1.81534302
29MP0003705_abnormal_hypodermis_morpholog1.78501416
30MP0003315_abnormal_perineum_morphology1.78469142
31MP0001697_abnormal_embryo_size1.75485677
32MP0004133_heterotaxia1.75216719
33MP0002160_abnormal_reproductive_system1.74520681
34MP0002009_preneoplasia1.68715451
35MP0003656_abnormal_erythrocyte_physiolo1.66901178
36MP0002653_abnormal_ependyma_morphology1.65709797
37MP0005666_abnormal_adipose_tissue1.63223384
38MP0003890_abnormal_embryonic-extraembry1.61603336
39MP0008995_early_reproductive_senescence1.60712187
40MP0003941_abnormal_skin_development1.60292256
41* MP0002085_abnormal_embryonic_tissue1.59671228
42MP0001188_hyperpigmentation1.57001886
43MP0003718_maternal_effect1.55863573
44MP0009053_abnormal_anal_canal1.55151952
45MP0001672_abnormal_embryogenesis/_devel1.53015581
46MP0005380_embryogenesis_phenotype1.53015581
47MP0003111_abnormal_nucleus_morphology1.52127130
48MP0005076_abnormal_cell_differentiation1.48037292
49MP0003935_abnormal_craniofacial_develop1.47664883
50MP0004957_abnormal_blastocyst_morpholog1.46436774
51MP0000462_abnormal_digestive_system1.45733564
52MP0008932_abnormal_embryonic_tissue1.45089371
53MP0010352_gastrointestinal_tract_polyps1.43147774
54MP0008877_abnormal_DNA_methylation1.42939565
55MP0001293_anophthalmia1.37873300
56MP0000003_abnormal_adipose_tissue1.37382912
57MP0000762_abnormal_tongue_morphology1.36667779
58MP0008007_abnormal_cellular_replicative1.36661011
59MP0000681_abnormal_thyroid_gland1.36223943
60MP0004782_abnormal_surfactant_physiolog1.35711155
61MP0003984_embryonic_growth_retardation1.35446444
62MP0005397_hematopoietic_system_phenotyp1.34456129
63MP0001545_abnormal_hematopoietic_system1.34456129
64MP0002111_abnormal_tail_morphology1.32647408
65MP0001879_abnormal_lymphatic_vessel1.31905633
66MP0005375_adipose_tissue_phenotype1.30998479
67MP0001730_embryonic_growth_arrest1.29672644
68MP0005174_abnormal_tail_pigmentation1.28790301
69MP0002088_abnormal_embryonic_growth/wei1.27645000
70MP0010630_abnormal_cardiac_muscle1.26443086
71MP0002932_abnormal_joint_morphology1.26000390
72MP0001661_extended_life_span1.24472522
73MP0006072_abnormal_retinal_apoptosis1.24377405
74MP0004264_abnormal_extraembryonic_tissu1.22264435
75MP0003755_abnormal_palate_morphology1.21963404
76MP0003937_abnormal_limbs/digits/tail_de1.19416222
77MP0003453_abnormal_keratinocyte_physiol1.18274939
78MP0002796_impaired_skin_barrier1.17409056
79MP0003077_abnormal_cell_cycle1.16934430
80MP0000534_abnormal_ureter_morphology1.15301943
81MP0000470_abnormal_stomach_morphology1.15244093
82* MP0000955_abnormal_spinal_cord1.14419810
83MP0000467_abnormal_esophagus_morphology1.12927472
84MP0003786_premature_aging1.12559227
85MP0000432_abnormal_head_morphology1.11806031
86MP0000579_abnormal_nail_morphology1.10507432
87MP0002925_abnormal_cardiovascular_devel1.09910976
88MP0002116_abnormal_craniofacial_bone1.09772454
89MP0000049_abnormal_middle_ear1.09051297
90MP0000350_abnormal_cell_proliferation1.08776507
91MP0008058_abnormal_DNA_repair1.08171646
92MP0003566_abnormal_cell_adhesion1.08016602
93MP0002080_prenatal_lethality1.07663789
94MP0001340_abnormal_eyelid_morphology1.06520793
95MP0000537_abnormal_urethra_morphology1.06029832
96MP0000490_abnormal_crypts_of1.05947128
97MP0003942_abnormal_urinary_system1.05483821
98MP0006036_abnormal_mitochondrial_physio1.05195444
99MP0001784_abnormal_fluid_regulation1.04791109
100MP0002114_abnormal_axial_skeleton1.04286434
101MP0003828_pulmonary_edema1.03519418
102MP0000516_abnormal_urinary_system1.01255689
103MP0005367_renal/urinary_system_phenotyp1.01255689
104MP0003115_abnormal_respiratory_system0.96497431
105MP0006035_abnormal_mitochondrial_morpho0.96075355
106MP0000266_abnormal_heart_morphology0.95096707
107MP0002098_abnormal_vibrissa_morphology0.94385905
108MP0001270_distended_abdomen0.94129843
109MP0005623_abnormal_meninges_morphology0.93010024
110MP0002102_abnormal_ear_morphology0.92103950
111MP0005501_abnormal_skin_physiology0.89995540
112MP0002269_muscular_atrophy0.86622908
113MP0000639_abnormal_adrenal_gland0.85913198
114MP0000733_abnormal_muscle_development0.83205387
115MP0009250_abnormal_appendicular_skeleto0.82590993
116MP0002060_abnormal_skin_morphology0.81876668
117MP0000313_abnormal_cell_death0.81337332
118MP0000428_abnormal_craniofacial_morphol0.80307919
119MP0009379_abnormal_foot_pigmentation0.77959214
120MP0002697_abnormal_eye_size0.77881087
121MP0000566_synostosis0.76414074
122MP0005508_abnormal_skeleton_morphology0.76395423
123MP0003938_abnormal_ear_development0.76307179
124MP0002081_perinatal_lethality0.76117809
125MP0000767_abnormal_smooth_muscle0.75639215
126MP0001727_abnormal_embryo_implantation0.74957071
127MP0003137_abnormal_impulse_conducting0.74626442
128MP0005670_abnormal_white_adipose0.74386948
129MP0001919_abnormal_reproductive_system0.74362383
130MP0005330_cardiomyopathy0.73481101
131MP0002109_abnormal_limb_morphology0.73078283
132MP0002163_abnormal_gland_morphology0.72614991
133MP0002127_abnormal_cardiovascular_syste0.72466123
134MP0002938_white_spotting0.71412203
135MP0009672_abnormal_birth_weight0.70854810
136MP0001145_abnormal_male_reproductive0.70268932
137MP0001873_stomach_inflammation0.69155755
138MP0002210_abnormal_sex_determination0.69016463
139MP0003861_abnormal_nervous_system0.68694760
140MP0005389_reproductive_system_phenotype0.67869884
141* MP0009333_abnormal_splenocyte_physiolog0.65950236
142MP0003698_abnormal_male_reproductive0.64883258
143MP0002152_abnormal_brain_morphology0.64465866
144MP0002233_abnormal_nose_morphology0.63942114
145MP0001929_abnormal_gametogenesis0.63496303
146MP0008770_decreased_survivor_rate0.62109407
147MP0000653_abnormal_sex_gland0.62070741
148MP0008961_abnormal_basal_metabolism0.60199848
149MP0002877_abnormal_melanocyte_morpholog0.59623128
150MP0001286_abnormal_eye_development0.57876903
151MP0002733_abnormal_thermal_nociception0.57489264
152MP0002161_abnormal_fertility/fecundity0.56176857
153MP0000759_abnormal_skeletal_muscle0.55944443
154MP0009697_abnormal_copulation0.55428852

Predicted human phenotypes

RankGene SetZ-score
1Double outlet right ventricle (HP:0001719)5.66719161
2Congenital malformation of the right heart (HP:0011723)5.66719161
3Rib fusion (HP:0000902)5.25425016
4Hypochromic microcytic anemia (HP:0004840)4.94453057
5Concave nail (HP:0001598)4.71648174
6Annular pancreas (HP:0001734)4.70098652
7Coronal craniosynostosis (HP:0004440)4.53519315
8Facial hemangioma (HP:0000329)4.43186616
9Abnormality of cochlea (HP:0000375)4.38601444
10Ulnar bowing (HP:0003031)4.34143239
11Truncus arteriosus (HP:0001660)4.23583733
12Rectal fistula (HP:0100590)4.14656860
13Rectovaginal fistula (HP:0000143)4.14656860
14Turricephaly (HP:0000262)4.13787079
15Septate vagina (HP:0001153)4.12580046
16Transposition of the great arteries (HP:0001669)3.96870562
17Broad distal phalanx of finger (HP:0009836)3.90779658
18Intestinal fistula (HP:0100819)3.76967435
19Preauricular pit (HP:0004467)3.72148393
20Periauricular skin pits (HP:0100277)3.72148393
21Pustule (HP:0200039)3.66534007
22Amelogenesis imperfecta (HP:0000705)3.61519635
23Birth length less than 3rd percentile (HP:0003561)3.50497517
24Vaginal fistula (HP:0004320)3.50038220
25Abnormality of the aortic arch (HP:0012303)3.46478831
26Microretrognathia (HP:0000308)3.39083465
27Morphological abnormality of the inner ear (HP:0011390)3.38141632
28Short humerus (HP:0005792)3.31033077
29Pancreatic islet-cell hyperplasia (HP:0004510)3.30829503
30Anteriorly placed anus (HP:0001545)3.26409541
31Aplasia/Hypoplasia of the sacrum (HP:0008517)3.25747671
32Alopecia of scalp (HP:0002293)3.24476579
33Microvesicular hepatic steatosis (HP:0001414)3.14297759
34Broad alveolar ridges (HP:0000187)3.14293739
35Aplasia/hypoplasia of the humerus (HP:0006507)3.12133293
36Poikiloderma (HP:0001029)3.10278347
37Squamous cell carcinoma (HP:0002860)2.98138893
38Increased IgM level (HP:0003496)2.94561361
39Selective tooth agenesis (HP:0001592)2.87202435
40Short 5th finger (HP:0009237)2.86205973
41Unilateral renal agenesis (HP:0000122)2.81905809
42Muscle fibrillation (HP:0010546)2.81735277
43Polycythemia (HP:0001901)2.79029176
44Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.77880029
45Cerebral aneurysm (HP:0004944)2.74581644
46Alacrima (HP:0000522)2.70003682
47Orthostatic hypotension (HP:0001278)2.69918000
48Tinnitus (HP:0000360)2.68656687
49Abnormal number of erythroid precursors (HP:0012131)2.64294558
50Hypoplastic left heart (HP:0004383)2.63616436
51Progressive muscle weakness (HP:0003323)2.60368164
52Intestinal atresia (HP:0011100)2.58350541
53Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.57947565
54Tongue fasciculations (HP:0001308)2.53603402
55Male infertility (HP:0003251)2.53401989
56Choanal stenosis (HP:0000452)2.53389765
57Hypochromic anemia (HP:0001931)2.52248564
58Skin pits (HP:0100276)2.52239829
59Broad toe (HP:0001837)2.51803599
60Basal cell carcinoma (HP:0002671)2.51399646
61Abnormal hemoglobin (HP:0011902)2.50601009
62Abnormality of cells of the erythroid lineage (HP:0012130)2.50523461
63Diaphragmatic weakness (HP:0009113)2.49944691
64Reticulocytopenia (HP:0001896)2.48551216
65Vertebral hypoplasia (HP:0008417)2.48118838
66Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.48118838
67Absent radius (HP:0003974)2.47754107
68Abnormality of the columella (HP:0009929)2.47329872
69Nephroblastoma (Wilms tumor) (HP:0002667)2.44783716
70Volvulus (HP:0002580)2.42789075
71Hyperthyroidism (HP:0000836)2.41617242
72Rectal prolapse (HP:0002035)2.39315444
73Patellar aplasia (HP:0006443)2.38862649
74Shawl scrotum (HP:0000049)2.36468467
75Broad thumb (HP:0011304)2.35698509
76Sparse lateral eyebrow (HP:0005338)2.35624494
77Bowing of the arm (HP:0006488)2.34651029
78Bowed forearm bones (HP:0003956)2.34651029
79Hypotrichosis (HP:0001006)2.34600792
80Narrow nasal bridge (HP:0000446)2.34320424
81Osteomalacia (HP:0002749)2.34181684
82Congenital hip dislocation (HP:0001374)2.33718591
83Embryonal renal neoplasm (HP:0011794)2.33396466
84Aplasia/Hypoplasia of the patella (HP:0006498)2.32196839
85Aplasia involving forearm bones (HP:0009822)2.30234823
86Absent forearm bone (HP:0003953)2.30234823
87Self-mutilation (HP:0000742)2.29874170
88Hamartoma (HP:0010566)2.29350630
89Hypertensive crisis (HP:0100735)2.28270750
90Ragged-red muscle fibers (HP:0003200)2.24625781
91Renal dysplasia (HP:0000110)2.24585908
92Diastasis recti (HP:0001540)2.23853672
93Capillary hemangiomas (HP:0005306)2.23807510
94Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23570204
95Breast hypoplasia (HP:0003187)2.23522913
96Vertebral fusion (HP:0002948)2.23007096
97Broad hallux (HP:0010055)2.20771283
9811 pairs of ribs (HP:0000878)2.17939035
99Hepatoblastoma (HP:0002884)2.14285312
100Short chin (HP:0000331)2.13595933
101Abnormality of the phalanges of the hallux (HP:0010057)2.13421252
102High anterior hairline (HP:0009890)2.11304406
103Large for gestational age (HP:0001520)2.11195157
104Bifid uvula (HP:0000193)2.10644555
105Renal duplication (HP:0000075)2.10018444
106Chromsome breakage (HP:0040012)2.09379389
107Abnormality of the pancreatic islet cells (HP:0006476)2.08875880
108Abnormality of endocrine pancreas physiology (HP:0012093)2.08875880
109Methylmalonic aciduria (HP:0012120)2.07894563
110Gastrointestinal atresia (HP:0002589)2.07185420
111Absent thumb (HP:0009777)2.06206922
112Abnormal number of incisors (HP:0011064)2.05576161
113Calcaneovalgus deformity (HP:0001848)2.05459369
114Abnormality of chromosome segregation (HP:0002916)2.04429331
115Short middle phalanx of the 5th finger (HP:0004220)2.03381201
116Preauricular skin tag (HP:0000384)2.00916492
117Exercise-induced myalgia (HP:0003738)2.00197257
118Abnormality of the lower motor neuron (HP:0002366)1.98007119
119Abnormality of nail color (HP:0100643)1.97455383
120Bilateral sensorineural hearing impairment (HP:0008619)1.97145989
121Increased number of teeth (HP:0011069)1.96908860
122Split hand (HP:0001171)1.96127440
123Abnormally folded helix (HP:0008544)1.95239230
124Hypoparathyroidism (HP:0000829)1.95165953
125Joint stiffness (HP:0001387)1.95081783
126Duplication of thumb phalanx (HP:0009942)1.94980936
127Seborrheic dermatitis (HP:0001051)1.94611183
128Obstructive sleep apnea (HP:0002870)1.93155506
129Homocystinuria (HP:0002156)1.93119273
130Abnormality of homocysteine metabolism (HP:0010919)1.93119273
131Hypoplastic heart (HP:0001961)1.93079201
132Abnormality of the fetal cardiovascular system (HP:0010948)1.92886556
133Abnormal umbilical cord blood vessels (HP:0011403)1.92886556
134Single umbilical artery (HP:0001195)1.92886556
135Astrocytoma (HP:0009592)1.91503207
136Abnormality of the astrocytes (HP:0100707)1.91503207
137Testicular atrophy (HP:0000029)1.91277652
138Premature graying of hair (HP:0002216)1.87556179
139Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87093677
140Optic nerve coloboma (HP:0000588)1.85836046
141Poikilocytosis (HP:0004447)1.84779702
142Cortical visual impairment (HP:0100704)1.82375483
143Neonatal hypoglycemia (HP:0001998)1.80602302
144Atresia of the external auditory canal (HP:0000413)1.80515908
145Ectopic anus (HP:0004397)1.79810664
146Abnormality of male internal genitalia (HP:0000022)1.79437398
147Abnormality of reticulocytes (HP:0004312)1.79122936
148Preaxial foot polydactyly (HP:0001841)1.78649316
149Abnormal tarsal ossification (HP:0008369)1.76756857
150Broad phalanges of the hand (HP:0009768)1.76065306
151Partial duplication of thumb phalanx (HP:0009944)1.75887873
152Premature skin wrinkling (HP:0100678)1.75750829
153Overfolded helix (HP:0000396)1.75462568
154Hypotelorism (HP:0000601)1.75315704
155Skin tags (HP:0010609)1.74811599
156Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74535207
157Short 4th metacarpal (HP:0010044)1.74535207
158Hemivertebrae (HP:0002937)1.73809089
159Abnormality of the calcaneus (HP:0008364)1.72761534
160Abnormal connection of the cardiac segments (HP:0011545)1.71980162
161Abnormal ventriculo-arterial connection (HP:0011563)1.71980162
162Pallor (HP:0000980)1.68366483
163Bifid scrotum (HP:0000048)1.67979111
164Atelectasis (HP:0100750)1.67594549
165Amblyopia (HP:0000646)1.67056075
166Ankle clonus (HP:0011448)1.65305284
167Premature ovarian failure (HP:0008209)1.65273279
168Abnormality of the intervertebral disk (HP:0005108)1.61890876
169Deformed tarsal bones (HP:0008119)1.61491798
170Underdeveloped supraorbital ridges (HP:0009891)1.61267454
171Short clavicles (HP:0000894)1.60876275
172Tracheal stenosis (HP:0002777)1.60628385
173Broad forehead (HP:0000337)1.60279480
174Proximal placement of thumb (HP:0009623)1.59537080
175Abnormal large intestine physiology (HP:0012700)1.57235042
176Impaired social interactions (HP:0000735)1.56638667
177Abnormal social behavior (HP:0012433)1.56638667
178Patent foramen ovale (HP:0001655)1.56617052
179Tetralogy of Fallot (HP:0001636)1.56375354
180Stridor (HP:0010307)1.55009703
181Plagiocephaly (HP:0001357)1.54470363

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.68211004
2DDR24.28478365
3MAP3K64.15453747
4SMG14.13139579
5SIK23.55294727
6MAPK153.41361658
7IRAK33.39590220
8MAP3K113.04676166
9FGR3.02691298
10CAMK1D2.88493838
11PDGFRA2.71175514
12TYRO32.67226844
13CAMK1G2.66028432
14MATK2.61579352
15BUB12.60259619
16PRKD22.58708534
17VRK22.46271458
18TAF12.41841651
19NME22.28017044
20MAP3K102.21444121
21PRKD32.07011264
22TRPM72.05181899
23BMX2.04463236
24CSK1.92379788
25PINK11.84868805
26UHMK11.76654386
27MAP2K71.73923772
28DAPK11.65952245
29TRIB31.65335628
30PIM21.61168305
31CDK71.57158884
32LATS21.55397220
33DYRK1B1.51387708
34YES11.50447450
35CDK121.47173675
36CDC42BPA1.41769958
37CSNK1G31.33758651
38AKT31.31010263
39PIM11.28485384
40BCKDK1.27935726
41PRPF4B1.25732916
42CHEK21.23039155
43CDK81.20579942
44TAOK21.19164035
45CSNK1A1L1.17987683
46MAPK111.16651875
47ILK1.13496693
48RPS6KC11.08237972
49RPS6KL11.08237972
50MAP3K41.06722401
51TRIM281.05117178
52IRAK21.04732845
53BRSK11.04341869
54STK161.02937727
55TLK11.01876996
56CDC70.99147789
57SRPK10.97951256
58NME10.96508137
59PKN20.95641657
60CDK60.95567346
61GSK3A0.95027633
62MAP2K40.91963468
63PHKG20.91162739
64PHKG10.91162739
65RPS6KA60.91106916
66TTK0.88687529
67MTOR0.87967910
68ZAK0.84816285
69PNCK0.82866745
70AKT20.82224628
71CAMKK20.81573309
72GRK10.80968754
73PLK10.79600671
74CASK0.78052527
75CSNK1G20.75956634
76TIE10.72240798
77EPHA40.71651032
78PRKCI0.70753609
79RPS6KA10.69101929
80PDGFRB0.68732638
81ARAF0.67770727
82NUAK10.66099677
83AURKB0.65859730
84WEE10.64290360
85CAMKK10.63898325
86KDR0.63489042
87ABL20.63158600
88VRK10.61125504
89BRAF0.61036481
90FGFR10.60566530
91DYRK30.60555264
92PAK20.58973762
93EEF2K0.58414877
94TTN0.57725874
95STK40.57561607
96RPS6KB20.56998058
97LATS10.56637625
98CCNB10.56533259
99BLK0.55659193
100CDK20.54659099
101PTK20.54467719
102CDK30.53430285
103EPHB20.53176770
104STK30.52885100
105MAP2K30.52775044
106PRKAA10.52766433
107DAPK30.49166474
108ACVR1B0.47817094
109DMPK0.47633363
110IRAK40.47293955
111EGFR0.45930401
112CAMK40.45653052
113MAPKAPK50.45354999
114SIK30.45046857
115ATR0.44272775
116MAP3K20.44102396
117DYRK20.43849268
118ATM0.43328914
119NEK20.42707660
120MAP2K60.41896137
121MELK0.40821775
122HIPK20.40786187
123CHEK10.40681960
124MAP3K30.40201412
125PRKD10.39159672
126LRRK20.38645752
127CSNK1E0.37846587
128TAOK10.37449083
129PRKAA20.36524702
130CDK90.36212307
131RPS6KA50.36071991
132CSNK2A10.35377349
133BRSK20.35037557
134AURKA0.34806782
135MAPK10.34737029
136RAF10.34161503
137RIPK10.34040853
138MAPK140.32035474
139MAP4K10.31854797
140MAP3K80.31778892
141PTK2B0.30994071
142PDPK10.30966161
143CDK150.30836632
144GSK3B0.30704663
145AKT10.30070779
146CDK11A0.30019292
147CDK10.29650784
148CSNK1G10.29563287
149ERBB30.29500727
150CDK40.28778088
151STK100.28560932
152CSNK2A20.28255658
153LYN0.28188489
154CDK180.28023421
155INSR0.27376405
156PTK60.27176398
157CDK140.27109971
158MAPK30.25293899
159ALK0.24647336
160CLK10.24506426
161MAPK100.24244758

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.25811101
2Mismatch repair_Homo sapiens_hsa034303.90739345
3Base excision repair_Homo sapiens_hsa034103.70959361
4DNA replication_Homo sapiens_hsa030303.23136748
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.05159913
6Systemic lupus erythematosus_Homo sapiens_hsa053222.73083811
7Hippo signaling pathway_Homo sapiens_hsa043902.52345617
8Hedgehog signaling pathway_Homo sapiens_hsa043402.47204131
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.46229038
10Notch signaling pathway_Homo sapiens_hsa043302.44725143
11Adherens junction_Homo sapiens_hsa045202.31927274
12mRNA surveillance pathway_Homo sapiens_hsa030152.23802048
13Vitamin B6 metabolism_Homo sapiens_hsa007502.15826948
14Cell cycle_Homo sapiens_hsa041101.93966149
15Pyrimidine metabolism_Homo sapiens_hsa002401.92264384
16Basal cell carcinoma_Homo sapiens_hsa052171.91892175
17Spliceosome_Homo sapiens_hsa030401.91230971
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90754113
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87866268
20TGF-beta signaling pathway_Homo sapiens_hsa043501.87171557
21mTOR signaling pathway_Homo sapiens_hsa041501.80493083
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80168908
23One carbon pool by folate_Homo sapiens_hsa006701.77832761
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77797987
25RNA transport_Homo sapiens_hsa030131.76255503
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73184176
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.63891040
28Bladder cancer_Homo sapiens_hsa052191.61348810
29Nucleotide excision repair_Homo sapiens_hsa034201.60434029
30Wnt signaling pathway_Homo sapiens_hsa043101.58398432
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56709407
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51032761
33p53 signaling pathway_Homo sapiens_hsa041151.49760865
34MicroRNAs in cancer_Homo sapiens_hsa052061.48217661
35Alcoholism_Homo sapiens_hsa050341.47509882
36* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.46263323
37Homologous recombination_Homo sapiens_hsa034401.43954531
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43303250
39Tight junction_Homo sapiens_hsa045301.40397074
40Lysine degradation_Homo sapiens_hsa003101.36561889
41RNA polymerase_Homo sapiens_hsa030201.32159541
42Viral carcinogenesis_Homo sapiens_hsa052031.31071561
43Arginine and proline metabolism_Homo sapiens_hsa003301.29630224
44Oocyte meiosis_Homo sapiens_hsa041141.26390846
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25918775
46Shigellosis_Homo sapiens_hsa051311.24630869
47VEGF signaling pathway_Homo sapiens_hsa043701.24117800
48Fanconi anemia pathway_Homo sapiens_hsa034601.20903684
49Small cell lung cancer_Homo sapiens_hsa052221.19916392
50Circadian rhythm_Homo sapiens_hsa047101.19112726
51Dorso-ventral axis formation_Homo sapiens_hsa043201.19012804
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18603900
53Fructose and mannose metabolism_Homo sapiens_hsa000511.12997121
54Non-homologous end-joining_Homo sapiens_hsa034501.11295826
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10757165
56Biosynthesis of amino acids_Homo sapiens_hsa012301.09591415
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04560593
58Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01948606
59Proteoglycans in cancer_Homo sapiens_hsa052051.01385456
60Gap junction_Homo sapiens_hsa045400.99961949
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98257650
62Focal adhesion_Homo sapiens_hsa045100.97823754
63Parkinsons disease_Homo sapiens_hsa050120.96890224
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94654961
65Colorectal cancer_Homo sapiens_hsa052100.93646992
66Viral myocarditis_Homo sapiens_hsa054160.91054355
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90529013
68Huntingtons disease_Homo sapiens_hsa050160.88754923
69Purine metabolism_Homo sapiens_hsa002300.88587064
70Chronic myeloid leukemia_Homo sapiens_hsa052200.86994132
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81744460
72Folate biosynthesis_Homo sapiens_hsa007900.77463356
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76909530
74Sulfur relay system_Homo sapiens_hsa041220.75370951
75Fatty acid metabolism_Homo sapiens_hsa012120.74899295
76Selenocompound metabolism_Homo sapiens_hsa004500.73854730
77HTLV-I infection_Homo sapiens_hsa051660.73853163
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71539410
79Endometrial cancer_Homo sapiens_hsa052130.70771309
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.69659586
81Phenylalanine metabolism_Homo sapiens_hsa003600.69153918
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.68288166
83Pathways in cancer_Homo sapiens_hsa052000.66129260
84Carbon metabolism_Homo sapiens_hsa012000.64650850
85Ribosome_Homo sapiens_hsa030100.64004803
86Rap1 signaling pathway_Homo sapiens_hsa040150.63125766
87AMPK signaling pathway_Homo sapiens_hsa041520.62982564
88Thyroid cancer_Homo sapiens_hsa052160.60769245
89Pentose phosphate pathway_Homo sapiens_hsa000300.59591585
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57782088
91Oxidative phosphorylation_Homo sapiens_hsa001900.57329578
92Prostate cancer_Homo sapiens_hsa052150.57223005
93Sulfur metabolism_Homo sapiens_hsa009200.56749290
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55963325
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.55742775
96Metabolic pathways_Homo sapiens_hsa011000.54677848
97Butanoate metabolism_Homo sapiens_hsa006500.54574009
98Prion diseases_Homo sapiens_hsa050200.54319934
99Fat digestion and absorption_Homo sapiens_hsa049750.54244785
100Inositol phosphate metabolism_Homo sapiens_hsa005620.54040126
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52614325
102Alzheimers disease_Homo sapiens_hsa050100.50495257
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.50414165
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48841164
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48564245
106ECM-receptor interaction_Homo sapiens_hsa045120.47951712
107ErbB signaling pathway_Homo sapiens_hsa040120.47431964
108MAPK signaling pathway_Homo sapiens_hsa040100.46734700
109Arginine biosynthesis_Homo sapiens_hsa002200.46641584
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46552408
111Axon guidance_Homo sapiens_hsa043600.46167406
112Renin-angiotensin system_Homo sapiens_hsa046140.45171803
113Melanogenesis_Homo sapiens_hsa049160.44970601
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44556371
115Insulin signaling pathway_Homo sapiens_hsa049100.43279465
116B cell receptor signaling pathway_Homo sapiens_hsa046620.43248306
117Galactose metabolism_Homo sapiens_hsa000520.43209755
118Melanoma_Homo sapiens_hsa052180.43166080
119GnRH signaling pathway_Homo sapiens_hsa049120.42097658
120Pancreatic cancer_Homo sapiens_hsa052120.41868695
121Choline metabolism in cancer_Homo sapiens_hsa052310.39635336
122Acute myeloid leukemia_Homo sapiens_hsa052210.39594394
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38038384
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37088455
125Estrogen signaling pathway_Homo sapiens_hsa049150.36923094
126Herpes simplex infection_Homo sapiens_hsa051680.36177679
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35883800
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.35235195
129Glucagon signaling pathway_Homo sapiens_hsa049220.33532135
130Peroxisome_Homo sapiens_hsa041460.33276393
131Non-small cell lung cancer_Homo sapiens_hsa052230.33218792
132Primary immunodeficiency_Homo sapiens_hsa053400.33000891
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32419926
134Dilated cardiomyopathy_Homo sapiens_hsa054140.31067549
135Renal cell carcinoma_Homo sapiens_hsa052110.31041324
136Endocytosis_Homo sapiens_hsa041440.30851385
137Dopaminergic synapse_Homo sapiens_hsa047280.30658001
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30301150
139Vibrio cholerae infection_Homo sapiens_hsa051100.30167544
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.29840244
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29613962
142Glioma_Homo sapiens_hsa052140.28636283
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28585958
144Epstein-Barr virus infection_Homo sapiens_hsa051690.28512742
145Platelet activation_Homo sapiens_hsa046110.28182175
146Basal transcription factors_Homo sapiens_hsa030220.27464172
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23959253
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23852352

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