TLX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)9.94741170
2regulation of cardioblast proliferation (GO:0003264)9.44461040
3regulation of secondary heart field cardioblast proliferation (GO:0003266)9.44461040
4cell migration involved in heart development (GO:0060973)9.36809174
5detection of temperature stimulus (GO:0016048)9.15839173
6detection of temperature stimulus involved in sensory perception of pain (GO:0050965)9.06205771
7detection of temperature stimulus involved in sensory perception (GO:0050961)9.06205771
8ganglion development (GO:0061548)8.70307916
9dopaminergic neuron differentiation (GO:0071542)8.60453491
10behavioral response to nicotine (GO:0035095)8.23155179
11peripheral nervous system neuron development (GO:0048935)8.05645380
12coronary vasculature morphogenesis (GO:0060977)7.85052983
13regulation of heart morphogenesis (GO:2000826)7.13781439
14cartilage morphogenesis (GO:0060536)6.91417388
15cell migration in hindbrain (GO:0021535)6.88648326
16endocardial cushion morphogenesis (GO:0003203)6.68704949
17cardiac ventricle formation (GO:0003211)6.42609343
18tongue development (GO:0043586)6.31277224
19cardiac chamber formation (GO:0003207)6.19517331
20positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)6.02029620
21positive regulation of cell cycle G2/M phase transition (GO:1902751)6.02029620
22neuronal action potential (GO:0019228)5.97947596
23regulation of respiratory gaseous exchange (GO:0043576)5.76191163
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.64934501
25mesenchyme morphogenesis (GO:0072132)5.49947973
26regulation of cell proliferation involved in heart morphogenesis (GO:2000136)5.39391239
27mesenchymal cell proliferation (GO:0010463)5.28572991
28nuclear pore complex assembly (GO:0051292)5.01605434
29negative regulation of striated muscle cell apoptotic process (GO:0010664)5.00216654
30negative regulation of calcium ion transport into cytosol (GO:0010523)4.99398164
31establishment of mitochondrion localization (GO:0051654)4.97583007
32neural crest cell migration (GO:0001755)4.95864616
33regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.95275355
34negative regulation of cell cycle arrest (GO:0071157)4.95009640
35behavioral response to pain (GO:0048266)4.91960909
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.89560637
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.89560637
38negative regulation of microtubule polymerization (GO:0031115)4.89254799
39response to pain (GO:0048265)4.75013756
40membrane depolarization during action potential (GO:0086010)4.68642822
41mitochondrion transport along microtubule (GO:0047497)4.66357104
42establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.66357104
43suckling behavior (GO:0001967)4.64222148
44response to water (GO:0009415)4.63875251
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.54193815
46cellular response to nicotine (GO:0071316)4.50302264
47intermediate filament organization (GO:0045109)4.47546309
48proline transport (GO:0015824)4.43136964
49nuclear pore organization (GO:0006999)4.42166129
50urinary tract smooth muscle contraction (GO:0014848)4.38640285
51neuronal action potential propagation (GO:0019227)4.36540682
52* negative regulation of dendrite morphogenesis (GO:0050774)4.29574758
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.23726477
54negative regulation of mRNA metabolic process (GO:1903312)4.23087541
55negative regulation of DNA repair (GO:0045738)4.21474344
56bundle of His cell to Purkinje myocyte communication (GO:0086069)4.19481360
57regulation of cardiac muscle cell apoptotic process (GO:0010665)4.14253333
58calcium-mediated signaling using intracellular calcium source (GO:0035584)4.11184667
59neuron fate specification (GO:0048665)4.10188177
60plasma membrane repair (GO:0001778)4.05565351
61retinal ganglion cell axon guidance (GO:0031290)4.04204558
62axon development (GO:0061564)4.03059856
63negative regulation of homotypic cell-cell adhesion (GO:0034111)4.02006376
64axon cargo transport (GO:0008088)4.01716233
65potassium ion export (GO:0071435)4.01614632
66regulation of respiratory system process (GO:0044065)3.92528739
67cell communication involved in cardiac conduction (GO:0086065)3.88959937
68adult heart development (GO:0007512)3.84081846
69detection of mechanical stimulus involved in sensory perception (GO:0050974)3.84018719
70apoptotic process involved in morphogenesis (GO:0060561)3.83631160
71synaptic vesicle maturation (GO:0016188)3.79761701
72ectodermal placode formation (GO:0060788)3.78216428
73regulation of translational termination (GO:0006449)3.74169388
74intermediate filament-based process (GO:0045103)3.70980374
75pore complex assembly (GO:0046931)3.68944506
76intermediate filament cytoskeleton organization (GO:0045104)3.66823587
77positive regulation of potassium ion transmembrane transport (GO:1901381)3.64892231
78regulation of platelet aggregation (GO:0090330)3.58193771
79neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.56359323
80innervation (GO:0060384)3.55354935
81DNA duplex unwinding (GO:0032508)3.53181096
82response to acidic pH (GO:0010447)3.49594261
83apoptotic process involved in development (GO:1902742)3.49535400
84body morphogenesis (GO:0010171)3.49349582
85viral mRNA export from host cell nucleus (GO:0046784)3.46126196
86membrane budding (GO:0006900)3.44421194
87organelle transport along microtubule (GO:0072384)3.43848710
88embryonic body morphogenesis (GO:0010172)3.42140491
89glutamate secretion (GO:0014047)3.39633366
90DNA geometric change (GO:0032392)3.38794655
91action potential (GO:0001508)3.38231925
92regulation of transcription regulatory region DNA binding (GO:2000677)3.37150984
93neuromuscular synaptic transmission (GO:0007274)3.35011474
94regulation of cell maturation (GO:1903429)3.32775140
95neural crest cell development (GO:0014032)3.32126006
96regulation of striated muscle cell apoptotic process (GO:0010662)3.31647713
97eyelid development in camera-type eye (GO:0061029)3.31259206
98embryonic digit morphogenesis (GO:0042733)3.31138719
99synaptic vesicle exocytosis (GO:0016079)3.30607714
100negative regulation of protein autophosphorylation (GO:0031953)3.30559528
101protein polyglutamylation (GO:0018095)3.29627333
102negative regulation of complement activation (GO:0045916)3.26260210
103DNA unwinding involved in DNA replication (GO:0006268)3.24463517
104regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.23367051
105neuromuscular process controlling posture (GO:0050884)3.23184089
106developmental programmed cell death (GO:0010623)3.20901029
107central nervous system neuron axonogenesis (GO:0021955)3.20577780
108synaptic transmission, cholinergic (GO:0007271)3.19511284
109adenosine metabolic process (GO:0046085)3.19215435
110positive regulation of cell cycle checkpoint (GO:1901978)3.17723201
111regulation of mRNA catabolic process (GO:0061013)3.17115866
112outflow tract septum morphogenesis (GO:0003148)3.16677478
113negative regulation of cell aging (GO:0090344)3.16415644
114sympathetic nervous system development (GO:0048485)3.14955855
115establishment of monopolar cell polarity (GO:0061162)3.14646750
116establishment or maintenance of monopolar cell polarity (GO:0061339)3.14646750
117regulation of synaptic vesicle exocytosis (GO:2000300)3.13973593
118negative regulation of histone acetylation (GO:0035067)3.13898457
119regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.13618444
120activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.13273989
121regulation of cAMP-dependent protein kinase activity (GO:2000479)3.12035236
122axon regeneration (GO:0031103)3.09327683
123cell differentiation in hindbrain (GO:0021533)3.09317112
124positive regulation of DNA binding (GO:0043388)3.09308541
125regulation of sodium ion transmembrane transporter activity (GO:2000649)3.08049344
126peristalsis (GO:0030432)3.07610577
127spliceosomal complex assembly (GO:0000245)3.06632470
128vesicle transport along microtubule (GO:0047496)3.05776073
129membrane repolarization (GO:0086009)3.04584043
130behavioral response to ethanol (GO:0048149)3.03726589
131sodium ion transmembrane transport (GO:0035725)3.02760525
132regulation of cell cycle G2/M phase transition (GO:1902749)3.02186437
133negative regulation of potassium ion transmembrane transport (GO:1901380)3.00178189
134regulation of NFAT protein import into nucleus (GO:0051532)2.99553793
135regulation of early endosome to late endosome transport (GO:2000641)2.99484862
136regulation of amyloid precursor protein catabolic process (GO:1902991)2.99395411
137positive regulation of axon extension (GO:0045773)2.99300268
138cellular response to BMP stimulus (GO:0071773)2.97700114
139response to BMP (GO:0071772)2.97700114
140positive regulation of potassium ion transport (GO:0043268)2.97444044
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.96820900
142acrosome reaction (GO:0007340)2.91820090
143regulation of membrane depolarization (GO:0003254)2.91215995
144skeletal muscle organ development (GO:0060538)2.87647474
145negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.87338321
146response to ATP (GO:0033198)2.86679431
147cytoskeleton-dependent intracellular transport (GO:0030705)2.86537918
148embryonic camera-type eye morphogenesis (GO:0048596)2.86012369
149spinal cord motor neuron differentiation (GO:0021522)2.85191524
150positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84864560
151microtubule-based transport (GO:0010970)2.83356877
152negative regulation of osteoblast differentiation (GO:0045668)2.82922960
153mesenchymal cell development (GO:0014031)2.82776378
154positive regulation of axonogenesis (GO:0050772)2.82396979
155negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.81554258
156negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81289268
157negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.80457576
158phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.79880286
159sister chromatid segregation (GO:0000819)2.79583196
160cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76452144
161SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.74930995
162positive regulation of cell size (GO:0045793)2.74627961
163positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73618636
164mitotic sister chromatid segregation (GO:0000070)2.72743054
165cranial nerve development (GO:0021545)2.72729776
166cellular response to ATP (GO:0071318)2.72354015
167regulation of potassium ion transmembrane transporter activity (GO:1901016)2.72146928
168alanine transport (GO:0032328)2.71955114
169dosage compensation (GO:0007549)2.70111221
170positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.70078629
171positive regulation of cardiac muscle hypertrophy (GO:0010613)2.70045334
172positive regulation of muscle hypertrophy (GO:0014742)2.70045334
173negative regulation of peptidyl-lysine acetylation (GO:2000757)2.69993884
174outer ear morphogenesis (GO:0042473)2.69663104
175negative regulation of cation channel activity (GO:2001258)2.68437752
176adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.68122125
177anterograde axon cargo transport (GO:0008089)2.64903330
178regulation of histone phosphorylation (GO:0033127)2.63952930
179regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57309814
180protein-DNA complex disassembly (GO:0032986)2.56681382
181nucleosome disassembly (GO:0006337)2.56681382
182regulation of organ formation (GO:0003156)2.56460233
183heart morphogenesis (GO:0003007)2.55447410
184regulation of centriole replication (GO:0046599)2.54466004
185DNA conformation change (GO:0071103)2.53400608
186negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.46412895
187DNA replication initiation (GO:0006270)2.43367288
188regulation of translational fidelity (GO:0006450)2.42232761
189positive regulation of fatty acid beta-oxidation (GO:0032000)2.38367616
190* enteric nervous system development (GO:0048484)11.2288282
191positive regulation of transcription regulatory region DNA binding (GO:2000679)10.2206195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.90379911
2GATA1_22025678_ChIP-Seq_K562_Human5.19531826
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.18009252
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.26714902
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77690055
6ESR1_15608294_ChIP-ChIP_MCF-7_Human3.42906511
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32379700
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03606301
9ZNF263_19887448_ChIP-Seq_K562_Human3.02347522
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.96284292
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92103643
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.75850683
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.72868613
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68222913
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67517891
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.60213278
17ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.56855262
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.46101689
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37137513
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30637877
21* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28017380
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24400696
23* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24400696
24* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23983193
25REST_21632747_ChIP-Seq_MESCs_Mouse2.20316611
26* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19571921
27* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13881215
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09794957
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.04649251
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04141164
31* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03269848
32* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00646287
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95496288
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.93145571
35KDM2B_26808549_Chip-Seq_K562_Human1.91709024
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.91149138
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87034463
38CTCF_27219007_Chip-Seq_Bcells_Human1.85250169
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85059498
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83849504
41* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82240105
42* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81757810
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.78257440
44VDR_22108803_ChIP-Seq_LS180_Human1.75042432
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74719359
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.72258721
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71243920
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68631239
49* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67772363
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66641020
51XRN2_22483619_ChIP-Seq_HELA_Human1.65391589
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64953564
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64554695
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.63289736
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62621463
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61612024
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61059012
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.58375902
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57463103
60TET1_21490601_ChIP-Seq_MESCs_Mouse1.55789166
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55593345
62* EZH2_27304074_Chip-Seq_ESCs_Mouse1.55263741
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53948017
64EZH2_22144423_ChIP-Seq_EOC_Human1.53067633
65AR_21909140_ChIP-Seq_LNCAP_Human1.52203160
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52115304
67* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51897190
68EGR1_19032775_ChIP-ChIP_M12_Human1.51663156
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51568961
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.50696108
71GBX2_23144817_ChIP-Seq_PC3_Human1.48329783
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47535407
73TTF2_22483619_ChIP-Seq_HELA_Human1.47510114
74TAF15_26573619_Chip-Seq_HEK293_Human1.46103706
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44279129
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40973508
77SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.40810359
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.39833629
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35730694
80AHR_22903824_ChIP-Seq_MCF-7_Human1.34975059
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33373916
82MYC_22102868_ChIP-Seq_BL_Human1.32041713
83* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31827404
84RARB_27405468_Chip-Seq_BRAIN_Mouse1.31697605
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.31104233
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.30579058
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29759817
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29069335
89* TP53_20018659_ChIP-ChIP_R1E_Mouse1.29009564
90LXR_22292898_ChIP-Seq_THP-1_Human1.28740260
91IGF1R_20145208_ChIP-Seq_DFB_Human1.28172744
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26734891
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22892909
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22565028
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22370668
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.22194221
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22011432
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20713305
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19233785
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18203576
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18114200
102SMAD4_21799915_ChIP-Seq_A2780_Human1.17580996
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17560944
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17475778
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17422130
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.15864681
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13624962
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13597521
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13348451
110* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11927033
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11482916
112RING1B_27294783_Chip-Seq_NPCs_Mouse1.10946677
113* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10733660
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10294991
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09680883
116* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09632989
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.09495755
118P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08817614
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06387970
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06036409
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05715895
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02501064
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02501064
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02501064
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02446770
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01707787
127RACK7_27058665_Chip-Seq_MCF-7_Human1.01687515
128CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01381803
129KLF4_19829295_ChIP-Seq_ESCs_Human1.00592900
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00209063
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99798755
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99462969
133ZNF274_21170338_ChIP-Seq_K562_Hela0.99335236
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99125477
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.99106174
136* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99090381
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.97995985
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.97758357
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97294175
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.97054744
141AR_21572438_ChIP-Seq_LNCaP_Human0.97044538
142SA1_27219007_Chip-Seq_Bcells_Human0.95611756
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.95411099
144* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95311178
145DCP1A_22483619_ChIP-Seq_HELA_Human0.95209757
146* SA1_27219007_Chip-Seq_ERYTHROID_Human0.94062526
147PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94000267
148PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.93727885
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93521345
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.93225482
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91615758
152KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91599896
153YY1_22570637_ChIP-Seq_MALME-3M_Human0.91339331
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.90838178
155FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90219731
156TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88945627
157KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88651877
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88505234
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.87782112
160GABP_17652178_ChIP-ChIP_JURKAT_Human0.87465016
161SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87346407
162KDM2B_26808549_Chip-Seq_DND41_Human0.86852061
163ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86643166
164CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86543777
165EST1_17652178_ChIP-ChIP_JURKAT_Human0.86357077
166MYC_18940864_ChIP-ChIP_HL60_Human0.84378671
167GABP_19822575_ChIP-Seq_HepG2_Human0.80618916
168SOX17_20123909_ChIP-Seq_XEN_Mouse0.80089928
169KDM5A_27292631_Chip-Seq_BREAST_Human0.79051340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex9.71853270
2MP0002735_abnormal_chemical_nociception8.14386669
3MP0001968_abnormal_touch/_nociception6.82260053
4MP0002736_abnormal_nociception_after6.24882916
5MP0004858_abnormal_nervous_system5.32043962
6MP0002733_abnormal_thermal_nociception4.80141623
7MP0004270_analgesia4.65558157
8MP0003567_abnormal_fetal_cardiomyocyte4.47716481
9MP0006276_abnormal_autonomic_nervous4.47404653
10MP0001986_abnormal_taste_sensitivity4.07766223
11MP0002822_catalepsy4.00206065
12MP0002734_abnormal_mechanical_nocicepti3.85831900
13MP0001970_abnormal_pain_threshold3.82935325
14MP0001348_abnormal_lacrimal_gland2.43835042
15MP0008961_abnormal_basal_metabolism2.23863798
16MP0002272_abnormal_nervous_system2.15351697
17MP0004859_abnormal_synaptic_plasticity2.09690606
18* MP0002751_abnormal_autonomic_nervous2.04225697
19MP0006138_congestive_heart_failure2.03421495
20MP0002067_abnormal_sensory_capabilities2.03276298
21MP0005187_abnormal_penis_morphology1.98435400
22MP0003077_abnormal_cell_cycle1.98233186
23* MP0002184_abnormal_innervation1.95382590
24MP0002127_abnormal_cardiovascular_syste1.94452642
25MP0005197_abnormal_uvea_morphology1.91291426
26MP0003111_abnormal_nucleus_morphology1.85499083
27MP0000955_abnormal_spinal_cord1.79303447
28MP0003937_abnormal_limbs/digits/tail_de1.72286219
29MP0003329_amyloid_beta_deposits1.71424327
30MP0010094_abnormal_chromosome_stability1.68008120
31MP0009046_muscle_twitch1.61413597
32MP0004811_abnormal_neuron_physiology1.60964028
33MP0003705_abnormal_hypodermis_morpholog1.60703503
34MP0008057_abnormal_DNA_replication1.59602071
35MP0003880_abnormal_central_pattern1.53971302
36MP0000372_irregular_coat_pigmentation1.52157235
37MP0003635_abnormal_synaptic_transmissio1.50149763
38MP0005083_abnormal_biliary_tract1.44542942
39MP0002697_abnormal_eye_size1.43399177
40MP0003656_abnormal_erythrocyte_physiolo1.42882809
41MP0008260_abnormal_autophagy1.38177381
42MP0008932_abnormal_embryonic_tissue1.35502730
43MP0001730_embryonic_growth_arrest1.34010057
44MP0000049_abnormal_middle_ear1.32168071
45MP0004147_increased_porphyrin_level1.31927801
46MP0003868_abnormal_feces_composition1.24291493
47MP0003115_abnormal_respiratory_system1.21734389
48MP0003935_abnormal_craniofacial_develop1.20570214
49MP0002064_seizures1.16873299
50MP0003693_abnormal_embryo_hatching1.15646828
51MP0010307_abnormal_tumor_latency1.15105616
52MP0004957_abnormal_blastocyst_morpholog1.12592804
53MP0002063_abnormal_learning/memory/cond1.09475354
54MP0005076_abnormal_cell_differentiation1.08756627
55MP0000538_abnormal_urinary_bladder1.07850654
56* MP0002882_abnormal_neuron_morphology1.06466749
57MP0009745_abnormal_behavioral_response1.05906749
58MP0010352_gastrointestinal_tract_polyps1.04984227
59MP0000778_abnormal_nervous_system1.02606591
60MP0001340_abnormal_eyelid_morphology1.02587441
61MP0002572_abnormal_emotion/affect_behav0.99438304
62MP0001661_extended_life_span0.99283982
63MP0000751_myopathy0.99019917
64* MP0002085_abnormal_embryonic_tissue0.96389533
65MP0000604_amyloidosis0.95829850
66MP0000534_abnormal_ureter_morphology0.95786597
67MP0002229_neurodegeneration0.95069311
68MP0003861_abnormal_nervous_system0.93518989
69MP0003634_abnormal_glial_cell0.93264693
70MP0004185_abnormal_adipocyte_glucose0.92603721
71MP0002752_abnormal_somatic_nervous0.92220759
72MP0001440_abnormal_grooming_behavior0.92218366
73MP0000537_abnormal_urethra_morphology0.91542338
74MP0002653_abnormal_ependyma_morphology0.90160955
75MP0004142_abnormal_muscle_tone0.89746771
76MP0008874_decreased_physiological_sensi0.89329324
77MP0000749_muscle_degeneration0.87794007
78MP0003633_abnormal_nervous_system0.87207686
79MP0005380_embryogenesis_phenotype0.87125970
80MP0001672_abnormal_embryogenesis/_devel0.87125970
81MP0002109_abnormal_limb_morphology0.86676379
82MP0005391_vision/eye_phenotype0.86536545
83MP0002092_abnormal_eye_morphology0.86344879
84* MP0002084_abnormal_developmental_patter0.86062148
85MP0008058_abnormal_DNA_repair0.85523501
86MP0000350_abnormal_cell_proliferation0.85373865
87MP0008007_abnormal_cellular_replicative0.84427557
88MP0005253_abnormal_eye_physiology0.83470519
89MP0003984_embryonic_growth_retardation0.83246424
90MP0000747_muscle_weakness0.83135273
91MP0000428_abnormal_craniofacial_morphol0.82969628
92MP0004197_abnormal_fetal_growth/weight/0.82379768
93MP0002066_abnormal_motor_capabilities/c0.81748526
94MP0008569_lethality_at_weaning0.80998751
95MP0002166_altered_tumor_susceptibility0.80664533
96MP0002088_abnormal_embryonic_growth/wei0.80270838
97MP0001697_abnormal_embryo_size0.79503431
98MP0003632_abnormal_nervous_system0.76678301
99* MP0000477_abnormal_intestine_morphology0.76408954
100MP0000762_abnormal_tongue_morphology0.76345248
101MP0003045_fibrosis0.75966068
102MP0003385_abnormal_body_wall0.75904548
103* MP0002080_prenatal_lethality0.75704111
104MP0002116_abnormal_craniofacial_bone0.75273762
105MP0002909_abnormal_adrenal_gland0.74785905
106MP0010771_integument_phenotype0.74256922
107MP0002932_abnormal_joint_morphology0.74195006
108* MP0001270_distended_abdomen0.74085729
109MP0005386_behavior/neurological_phenoty0.74064711
110MP0004924_abnormal_behavior0.74064711
111MP0001299_abnormal_eye_distance/0.73896256
112MP0002114_abnormal_axial_skeleton0.73753523
113MP0005193_abnormal_anterior_eye0.70347443
114MP0010030_abnormal_orbit_morphology0.69725269
115MP0009250_abnormal_appendicular_skeleto0.69261506
116MP0000313_abnormal_cell_death0.67657427
117MP0003631_nervous_system_phenotype0.67290031
118MP0004233_abnormal_muscle_weight0.67056278
119MP0003755_abnormal_palate_morphology0.65779951
120MP0005423_abnormal_somatic_nervous0.64947491
121MP0002163_abnormal_gland_morphology0.64468547
122MP0004145_abnormal_muscle_electrophysio0.63402423
123MP0001984_abnormal_olfaction0.63396931
124MP0005369_muscle_phenotype0.62174708
125MP0002081_perinatal_lethality0.61992049
126MP0004883_abnormal_blood_vessel0.61874029
127MP0003948_abnormal_gas_homeostasis0.61562028
128MP0008872_abnormal_physiological_respon0.59842489
129MP0003448_altered_tumor_morphology0.59232848
130MP0005171_absent_coat_pigmentation0.58844141
131MP0005646_abnormal_pituitary_gland0.58686872
132MP0003172_abnormal_lysosome_physiology0.58660183
133MP0002106_abnormal_muscle_physiology0.57788210
134MP0000681_abnormal_thyroid_gland0.57590967
135MP0002160_abnormal_reproductive_system0.57326849
136MP0009379_abnormal_foot_pigmentation0.56885177
137MP0000733_abnormal_muscle_development0.55609258
138* MP0010770_preweaning_lethality0.55364163
139* MP0002082_postnatal_lethality0.55364163
140MP0009697_abnormal_copulation0.54524114
141MP0002269_muscular_atrophy0.54015471
142MP0009278_abnormal_bone_marrow0.53105000
143* MP0010769_abnormal_survival0.52472572
144MP0001849_ear_inflammation0.52425877
145MP0002557_abnormal_social/conspecific_i0.52239512
146MP0003943_abnormal_hepatobiliary_system0.52123773
147MP0004085_abnormal_heartbeat0.51063590
148MP0000639_abnormal_adrenal_gland0.50803581
149MP0001963_abnormal_hearing_physiology0.49423857
150MP0000579_abnormal_nail_morphology0.49210225
151MP0000759_abnormal_skeletal_muscle0.48797745
152MP0001486_abnormal_startle_reflex0.47857594
153MP0004036_abnormal_muscle_relaxation0.47775918
154MP0002009_preneoplasia0.47553654
155MP0008775_abnormal_heart_ventricle0.47209858
156MP0001905_abnormal_dopamine_level0.45781462
157MP0002837_dystrophic_cardiac_calcinosis0.45477499
158MP0003283_abnormal_digestive_organ0.44459723
159MP0001943_abnormal_respiration0.43787296
160MP0003183_abnormal_peptide_metabolism0.43711633
161MP0010386_abnormal_urinary_bladder0.42147472
162MP0003942_abnormal_urinary_system0.41989734
163MP0003137_abnormal_impulse_conducting0.41786903
164MP0003806_abnormal_nucleotide_metabolis0.40791553
165MP0000920_abnormal_myelination0.39121890
166MP0002972_abnormal_cardiac_muscle0.38633151
167MP0003315_abnormal_perineum_morphology0.37983060
168MP0001664_abnormal_digestion0.37788897
169MP0003122_maternal_imprinting0.37338101
170MP0005623_abnormal_meninges_morphology0.36649246
171MP0000427_abnormal_hair_cycle0.33248684
172MP0001919_abnormal_reproductive_system0.32312149
173MP0005410_abnormal_fertilization0.31190225
174MP0003879_abnormal_hair_cell0.31152309

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.75587349
2Myokymia (HP:0002411)6.89638131
3Abnormality of the phalanges of the 2nd finger (HP:0009541)6.63205042
4Action tremor (HP:0002345)5.71750201
5Dysautonomia (HP:0002459)5.60157910
6Breast hypoplasia (HP:0003187)5.53546230
7Segmental peripheral demyelination/remyelination (HP:0003481)5.48944620
8Esophageal atresia (HP:0002032)5.21193985
9Pheochromocytoma (HP:0002666)5.18953227
10Termporal pattern (HP:0011008)5.07130756
11Insidious onset (HP:0003587)5.07130756
12Impaired pain sensation (HP:0007328)4.79439416
13Abnormality of pain sensation (HP:0010832)4.79439416
14Neuroendocrine neoplasm (HP:0100634)4.73081980
15Foot dorsiflexor weakness (HP:0009027)4.38481314
16Intestinal atresia (HP:0011100)4.31735178
17Steppage gait (HP:0003376)4.24123312
18Abnormality of the 2nd finger (HP:0004100)4.23499339
19Hammertoe (HP:0001765)4.22702709
20Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.18743140
21Abnormality of the phalanges of the hallux (HP:0010057)4.12243111
22Abnormality of the foot musculature (HP:0001436)3.90183192
23Depressed nasal tip (HP:0000437)3.80945378
24Febrile seizures (HP:0002373)3.79896748
25Hypercortisolism (HP:0001578)3.77670662
26Hypothermia (HP:0002045)3.73051119
27Supranuclear gaze palsy (HP:0000605)3.67008055
28Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.64758348
29Abnormal autonomic nervous system physiology (HP:0012332)3.63931830
30Supernumerary spleens (HP:0009799)3.56829915
31Failure to thrive in infancy (HP:0001531)3.48628722
32Atonic seizures (HP:0010819)3.45185415
33Hypoplastic nipples (HP:0002557)3.43135156
34Autoamputation (HP:0001218)3.42176077
35Hyporeflexia of lower limbs (HP:0002600)3.41059702
36Myotonia (HP:0002486)3.37432717
37Distal arthrogryposis (HP:0005684)3.29329967
38Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.28698705
39Distal sensory impairment (HP:0002936)3.28564599
40Turricephaly (HP:0000262)3.26343690
41Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.26185289
42Shawl scrotum (HP:0000049)3.24689899
43Areflexia of lower limbs (HP:0002522)3.19411944
44Onion bulb formation (HP:0003383)3.18809306
45Neuroepithelial neoplasm (HP:0030063)3.15092541
46Nervous tissue neoplasm (HP:0030060)3.15092541
47Neuroectodermal neoplasm (HP:0030061)3.15092541
48Malignant neoplasm of the central nervous system (HP:0100836)3.14812647
49Ankle clonus (HP:0011448)3.11357112
50Distal lower limb muscle weakness (HP:0009053)3.09167719
51Secondary amenorrhea (HP:0000869)3.04250187
52Decreased motor nerve conduction velocity (HP:0003431)3.03039016
53Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02600900
54Orthostatic hypotension (HP:0001278)2.98456266
55Tubulointerstitial fibrosis (HP:0005576)2.98042588
56Partial duplication of the phalanx of hand (HP:0009999)2.97471786
57External ophthalmoplegia (HP:0000544)2.97429355
58Neoplasm of the peripheral nervous system (HP:0100007)2.96928983
59Thyroid carcinoma (HP:0002890)2.93270576
60Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.89568021
61Gastrointestinal atresia (HP:0002589)2.86421233
62Focal seizures (HP:0007359)2.78548754
63Sandal gap (HP:0001852)2.77213606
64Abnormality of the corticospinal tract (HP:0002492)2.75865268
65Abnormality of the vocal cords (HP:0008777)2.73945242
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.73772686
67Long toe (HP:0010511)2.73001616
68Chromsome breakage (HP:0040012)2.72479280
69Midline defect of the nose (HP:0004122)2.69717570
70Delayed cranial suture closure (HP:0000270)2.68456007
71Submucous cleft hard palate (HP:0000176)2.64411832
72Abnormality of the phalanges of the 5th finger (HP:0004213)2.64030494
73Hypoplasia of the brainstem (HP:0002365)2.62269290
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.62269290
75Type 2 muscle fiber atrophy (HP:0003554)2.57958028
76Hypoventilation (HP:0002791)2.57679812
77Urinary urgency (HP:0000012)2.56704221
78Hypotrichosis (HP:0001006)2.56568827
79Palpebral edema (HP:0100540)2.56154663
80Hypoproteinemia (HP:0003075)2.52731615
81Abnormality of the parietal bone (HP:0002696)2.52217941
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46630563
83Progressive cerebellar ataxia (HP:0002073)2.44347948
84Spastic gait (HP:0002064)2.44016546
85Abnormality of the lower motor neuron (HP:0002366)2.42076547
86Arthropathy (HP:0003040)2.41616814
87Thoracolumbar scoliosis (HP:0002944)2.37281507
88Bradycardia (HP:0001662)2.36804515
89Limb dystonia (HP:0002451)2.34688928
90Chin dimple (HP:0010751)2.33134352
91Annular pancreas (HP:0001734)2.32541090
92Amblyopia (HP:0000646)2.29990508
93Muscle fiber atrophy (HP:0100295)2.29837855
94EMG: neuropathic changes (HP:0003445)2.29554850
95Bowel diverticulosis (HP:0005222)2.29311788
96Facial asymmetry (HP:0000324)2.27191203
97Hyperparathyroidism (HP:0000843)2.25718728
98Fasciculations (HP:0002380)2.25327388
99Patellar aplasia (HP:0006443)2.25302666
100Tubulointerstitial abnormality (HP:0001969)2.23473715
101Potter facies (HP:0002009)2.22207751
102Facial shape deformation (HP:0011334)2.22207751
103Short palpebral fissure (HP:0012745)2.20965715
104Ventricular fibrillation (HP:0001663)2.19831850
105Overlapping toe (HP:0001845)2.19153544
106Coronal craniosynostosis (HP:0004440)2.18550452
107Bicornuate uterus (HP:0000813)2.18201011
108Poor suck (HP:0002033)2.15781180
109Muscle stiffness (HP:0003552)2.14504888
110Abnormal sex determination (HP:0012244)2.13389833
111Sex reversal (HP:0012245)2.13389833
112Cerebral hemorrhage (HP:0001342)2.12054947
113Asplenia (HP:0001746)2.08312006
114Muscle fibrillation (HP:0010546)2.07506836
115Generalized hypotonia (HP:0001290)2.06742327
116Abnormality of the musculature of the hand (HP:0001421)2.05574704
117Keratoconus (HP:0000563)2.05140813
118Increased corneal curvature (HP:0100692)2.05140813
119Abnormality of the parathyroid morphology (HP:0011766)2.05088052
120Aplasia/Hypoplasia of the patella (HP:0006498)2.04886948
121Impaired proprioception (HP:0010831)2.04566809
122Delusions (HP:0000746)2.04209735
123Absence seizures (HP:0002121)2.04174004
124Focal motor seizures (HP:0011153)2.03264247
125Menstrual irregularities (HP:0000858)2.03225449
126Postural tremor (HP:0002174)2.03026000
127Abnormality of magnesium homeostasis (HP:0004921)2.02896075
128Peripheral demyelination (HP:0011096)2.01993123
129Mask-like facies (HP:0000298)2.01414392
130Neonatal hypoglycemia (HP:0001998)2.00707079
131Asymmetry of the thorax (HP:0001555)10.3245518
132Growth hormone excess (HP:0000845)1.98959302
133Wide anterior fontanel (HP:0000260)1.98310941
134Urinary bladder sphincter dysfunction (HP:0002839)1.98023024
135Paraplegia (HP:0010550)1.95476302
136Truncal ataxia (HP:0002078)1.95045486
137Lower limb muscle weakness (HP:0007340)1.94728789
138Abnormality of intracranial pressure (HP:0012640)1.93207960
139Increased intracranial pressure (HP:0002516)1.93207960
140Abnormality of calcium-phosphate metabolism (HP:0100530)1.92365329
141Hand muscle atrophy (HP:0009130)1.90857470
142Aplasia/Hypoplasia of the nipples (HP:0006709)1.88873672
143Hyperacusis (HP:0010780)1.88400248
144Ectopic kidney (HP:0000086)1.87580048
145Dialeptic seizures (HP:0011146)1.87569060
146Abnormality of the duodenum (HP:0002246)1.86691306
147Neonatal onset (HP:0003623)1.85040570
148Pes cavus (HP:0001761)1.84151531
149Buphthalmos (HP:0000557)1.83609007
150Renovascular hypertension (HP:0100817)1.82906124
151Increased CSF protein (HP:0002922)1.82809070
152Abnormal hemoglobin (HP:0011902)1.82672208
153Protruding ear (HP:0000411)1.82534151
154Down-sloping shoulders (HP:0200021)1.81098262
155Visual hallucinations (HP:0002367)1.80334036
156Neuroblastic tumors (HP:0004376)1.79879667
157Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.79879667
158Neuroblastoma (HP:0003006)1.79879667
159Primitive neuroectodermal tumor (HP:0030065)1.79879667
160Anosmia (HP:0000458)1.79030834
161Spastic paraplegia (HP:0001258)1.78587625
162Rapidly progressive (HP:0003678)1.77460271
163Disproportionate tall stature (HP:0001519)1.76870769
164Thick eyebrow (HP:0000574)1.76725476
165Exotropia (HP:0000577)1.76474564
166Abnormality of the aortic arch (HP:0012303)1.76127401
167Generalized tonic-clonic seizures (HP:0002069)1.75776082
168Prominent occiput (HP:0000269)1.74712682
169Brachycephaly (HP:0000248)1.72987773
170Abnormality of the 4th metacarpal (HP:0010012)1.72824755
171Renal dysplasia (HP:0000110)1.72607248
172Underdeveloped supraorbital ridges (HP:0009891)1.69913533
173Absent radius (HP:0003974)1.69553348
174Abnormality of the distal phalanx of the thumb (HP:0009617)1.69458194
175Abnormality of the carotid arteries (HP:0005344)1.66860029
176Meckel diverticulum (HP:0002245)1.65797864
177Broad distal phalanx of finger (HP:0009836)1.62391817
178Decreased skull ossification (HP:0004331)1.61239310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.11659654
2NTRK15.00625650
3PLK44.04466050
4LMTK23.96399733
5SRPK13.67800868
6TLK13.66104481
7MATK3.58986560
8MAPKAPK33.44980368
9ZAK3.25760431
10MINK13.24930634
11MAP3K93.24139537
12LATS23.12169442
13NTRK33.09651300
14KSR22.95037085
15NME22.93671085
16INSRR2.88968581
17LIMK12.39627893
18PBK2.35350412
19ARAF2.26559294
20GRK52.23186536
21MAP3K22.01367612
22PHKG11.99189318
23PHKG21.99189318
24RET1.97916015
25AKT31.95708056
26ALK1.92433392
27CDC71.88862446
28EEF2K1.87394585
29MAP3K111.82107648
30RIPK41.78523175
31MAP3K121.77967725
32BUB11.70423867
33EPHA31.69508298
34PAK61.64543071
35MAP2K41.57705153
36DYRK1B1.57634263
37SCYL21.49324388
38MAP3K41.47877199
39PIM21.45090571
40TRIB31.44386210
41NME11.43479643
42FGFR21.43243032
43BRD41.43098471
44UHMK11.36939339
45WNK11.33973659
46MAP2K11.33415981
47NEK11.29189415
48FER1.26087708
49PINK11.25439661
50CDK81.19777066
51CDK121.19236154
52CDK41.19016214
53TTK1.17417394
54TYRO31.16828288
55RPS6KA21.13717255
56NTRK21.12237211
57CHEK21.11592572
58CDK61.09674322
59MAP2K71.07017006
60MTOR1.06779236
61MAP3K11.01516631
62ATR0.99460299
63MARK30.99177803
64CDK70.97529033
65YES10.96221723
66ADRBK10.95887251
67MAPK110.94736344
68STK390.94373111
69CASK0.88838498
70VRK10.87945927
71WNK40.87627692
72SMG10.86561945
73MKNK20.86191805
74SGK2230.85277319
75SGK4940.85277319
76MAPK130.85039325
77EIF2AK10.83925587
78CAMKK20.83652094
79DDR20.82262591
80MET0.81489862
81CDK140.78909547
82MAP2K20.77060153
83PRKG20.76509993
84SIK30.76055067
85CDK50.75886787
86RPS6KB20.74128862
87TSSK60.73953646
88MAP2K30.66226500
89PTK20.66083191
90ICK0.65925340
91BRSK10.65839266
92AURKB0.63940272
93RIPK10.63002642
94BMPR1B0.62186294
95CAMKK10.61897127
96PAK40.61306785
97PLK10.60522610
98CDK20.60359748
99SGK20.59019065
100MAPKAPK50.58904123
101PKN10.58622101
102MAPK150.57880215
103AKT20.57452926
104CHEK10.57294103
105AURKA0.56774085
106PDGFRB0.56771570
107BRAF0.55645387
108PRKCG0.54545598
109EPHB10.53901857
110CAMK2G0.53779644
111IRAK20.52853338
112ATM0.51264407
113RAF10.51066369
114DYRK20.50641413
115NEK90.50286014
116DAPK10.49443541
117NEK20.48464643
118FLT30.48386259
119STK40.47964171
120CSNK1G30.47315059
121MKNK10.46936279
122CDK180.46936169
123RPS6KL10.45796038
124RPS6KC10.45796038
125DAPK20.45503528
126TRPM70.44943715
127IRAK10.44825354
128PDGFRA0.44683929
129PDPK10.44310127
130CDK10.43918635
131CSNK1A1L0.43784710
132CDC42BPA0.42665463
133AKT10.42582397
134CDK150.42567661
135HIPK20.42451403
136CLK10.40370675
137CSNK1G10.40314981
138ADRBK20.40048524
139CSNK1G20.39020471
140RPS6KA50.38897670
141PRKCE0.38861900
142PAK30.38751927
143PRKCZ0.38544538
144PIM10.36977780
145PDK10.36616256
146CAMK2A0.36475278
147PKN20.36200071
148FGFR30.36119974
149SGK30.35994689
150CDK11A0.35430957
151CAMK40.33989227
152FGR0.33981227
153CDK30.33885059
154MAPK100.33212229
155MELK0.32569627
156RPS6KA60.32417536
157GRK70.32237107
158MAPK140.32179867
159CSNK1E0.31092860
160BLK0.31003789
161MAP2K60.30834329
162FGFR40.29935009
163ERBB20.29829254
164TAOK10.28336266
165PRKDC0.27349232
166PRKACG0.27217529
167MAP3K60.27003894
168PRKD30.26455658
169PRKACA0.25658171
170PRKAA10.24741274
171MAPK10.24254191
172CSNK2A20.24026816
173PRPF4B0.23983853
174PASK0.23572613
175PRKD20.21778013

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.98265492
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.84712651
3DNA replication_Homo sapiens_hsa030303.54510532
4Synaptic vesicle cycle_Homo sapiens_hsa047213.46342732
5Systemic lupus erythematosus_Homo sapiens_hsa053223.34559224
6Alcoholism_Homo sapiens_hsa050343.23133509
7Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.95895357
8Non-homologous end-joining_Homo sapiens_hsa034502.71759144
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.68875747
10Non-small cell lung cancer_Homo sapiens_hsa052232.67481181
11Spliceosome_Homo sapiens_hsa030402.58302621
12Thyroid cancer_Homo sapiens_hsa052162.44496356
13Cell cycle_Homo sapiens_hsa041102.40474305
14RNA transport_Homo sapiens_hsa030132.33550591
15Fanconi anemia pathway_Homo sapiens_hsa034602.24763756
16Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.24083939
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.13660092
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12021197
19mRNA surveillance pathway_Homo sapiens_hsa030152.11083777
20Base excision repair_Homo sapiens_hsa034102.06744583
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99723845
22Mismatch repair_Homo sapiens_hsa034301.96099792
23Taste transduction_Homo sapiens_hsa047421.89886472
24Olfactory transduction_Homo sapiens_hsa047401.84296619
25Dorso-ventral axis formation_Homo sapiens_hsa043201.83490519
26Dopaminergic synapse_Homo sapiens_hsa047281.68704872
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62406825
28Insulin secretion_Homo sapiens_hsa049111.61492848
29Chronic myeloid leukemia_Homo sapiens_hsa052201.59397834
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.58479060
31Pyrimidine metabolism_Homo sapiens_hsa002401.55464210
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.52285811
33One carbon pool by folate_Homo sapiens_hsa006701.51782507
34RNA polymerase_Homo sapiens_hsa030201.48162107
35VEGF signaling pathway_Homo sapiens_hsa043701.46670294
36MicroRNAs in cancer_Homo sapiens_hsa052061.45110955
37Gap junction_Homo sapiens_hsa045401.44901766
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41730559
39GnRH signaling pathway_Homo sapiens_hsa049121.41606784
40Biosynthesis of amino acids_Homo sapiens_hsa012301.31685310
41Insulin signaling pathway_Homo sapiens_hsa049101.31097972
42Lysine degradation_Homo sapiens_hsa003101.29987324
43Oocyte meiosis_Homo sapiens_hsa041141.28827447
44Nucleotide excision repair_Homo sapiens_hsa034201.26903047
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25766248
46Cholinergic synapse_Homo sapiens_hsa047251.23839674
47Cardiac muscle contraction_Homo sapiens_hsa042601.23727487
48Steroid biosynthesis_Homo sapiens_hsa001001.22040233
49Viral carcinogenesis_Homo sapiens_hsa052031.21855062
50Salivary secretion_Homo sapiens_hsa049701.20185876
51Colorectal cancer_Homo sapiens_hsa052101.20069846
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19885021
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19638539
54ErbB signaling pathway_Homo sapiens_hsa040121.18231368
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17251689
56Salmonella infection_Homo sapiens_hsa051321.16465221
57Long-term potentiation_Homo sapiens_hsa047201.15111910
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11457614
59Homologous recombination_Homo sapiens_hsa034401.09922952
60Glioma_Homo sapiens_hsa052141.08303059
61Prolactin signaling pathway_Homo sapiens_hsa049171.06737571
62Collecting duct acid secretion_Homo sapiens_hsa049661.06657427
63Parkinsons disease_Homo sapiens_hsa050121.06178303
64Renin-angiotensin system_Homo sapiens_hsa046141.03517884
65mTOR signaling pathway_Homo sapiens_hsa041501.03227967
66Sphingolipid signaling pathway_Homo sapiens_hsa040711.03224164
67Pancreatic cancer_Homo sapiens_hsa052121.00257200
68Estrogen signaling pathway_Homo sapiens_hsa049150.98635186
69Regulation of autophagy_Homo sapiens_hsa041400.98592607
70Small cell lung cancer_Homo sapiens_hsa052220.98433350
71Endocytosis_Homo sapiens_hsa041440.98207713
72Endometrial cancer_Homo sapiens_hsa052130.96944070
73Melanoma_Homo sapiens_hsa052180.96378871
74Selenocompound metabolism_Homo sapiens_hsa004500.96253964
75Arginine biosynthesis_Homo sapiens_hsa002200.96215701
76Long-term depression_Homo sapiens_hsa047300.95409787
77Circadian entrainment_Homo sapiens_hsa047130.94946521
78Phagosome_Homo sapiens_hsa041450.93262987
79Prostate cancer_Homo sapiens_hsa052150.92637053
80Vibrio cholerae infection_Homo sapiens_hsa051100.92446478
81Serotonergic synapse_Homo sapiens_hsa047260.92161114
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91104926
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89750757
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87181372
85Inositol phosphate metabolism_Homo sapiens_hsa005620.85644338
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84333408
87Choline metabolism in cancer_Homo sapiens_hsa052310.84162681
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84061415
89Melanogenesis_Homo sapiens_hsa049160.83800745
90Hedgehog signaling pathway_Homo sapiens_hsa043400.83647314
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.82997398
92Gastric acid secretion_Homo sapiens_hsa049710.81262172
93Oxidative phosphorylation_Homo sapiens_hsa001900.80206719
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79632245
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78604521
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77676814
97Glutamatergic synapse_Homo sapiens_hsa047240.77141388
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76382299
99Bile secretion_Homo sapiens_hsa049760.73412178
100Oxytocin signaling pathway_Homo sapiens_hsa049210.71768963
101Amphetamine addiction_Homo sapiens_hsa050310.71669324
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71142915
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69866966
104Shigellosis_Homo sapiens_hsa051310.69280259
105Calcium signaling pathway_Homo sapiens_hsa040200.67889000
106Ribosome_Homo sapiens_hsa030100.67810515
107p53 signaling pathway_Homo sapiens_hsa041150.67457682
108Basal cell carcinoma_Homo sapiens_hsa052170.67426585
109Tyrosine metabolism_Homo sapiens_hsa003500.67113577
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66688354
111Alzheimers disease_Homo sapiens_hsa050100.66472167
112TGF-beta signaling pathway_Homo sapiens_hsa043500.66023911
113Renin secretion_Homo sapiens_hsa049240.65923558
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65717567
115Pyruvate metabolism_Homo sapiens_hsa006200.64529607
116Rap1 signaling pathway_Homo sapiens_hsa040150.64472556
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.64457803
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62773163
119Axon guidance_Homo sapiens_hsa043600.62561995
120Proteasome_Homo sapiens_hsa030500.61867944
121Purine metabolism_Homo sapiens_hsa002300.61267084
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60719905
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60099024
124Prion diseases_Homo sapiens_hsa050200.59509084
125Type II diabetes mellitus_Homo sapiens_hsa049300.58568856
126MAPK signaling pathway_Homo sapiens_hsa040100.58344696
127Thyroid hormone synthesis_Homo sapiens_hsa049180.58165097
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.57843438
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57758737
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57329176
131Basal transcription factors_Homo sapiens_hsa030220.56730180
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56416540
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56234091
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55525598
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.55440231
136Glucagon signaling pathway_Homo sapiens_hsa049220.55284478
137Sulfur relay system_Homo sapiens_hsa041220.54741517
138Pancreatic secretion_Homo sapiens_hsa049720.54389294
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.53905933
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53700932
141Wnt signaling pathway_Homo sapiens_hsa043100.53052275
142AMPK signaling pathway_Homo sapiens_hsa041520.53008870
143Notch signaling pathway_Homo sapiens_hsa043300.52354732
144Mineral absorption_Homo sapiens_hsa049780.51701152
145Glycerolipid metabolism_Homo sapiens_hsa005610.50310240
146Huntingtons disease_Homo sapiens_hsa050160.50081896
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48793765
148Fatty acid biosynthesis_Homo sapiens_hsa000610.48438943
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47942912
150Bladder cancer_Homo sapiens_hsa052190.47855624
151Proteoglycans in cancer_Homo sapiens_hsa052050.47665315
152Ras signaling pathway_Homo sapiens_hsa040140.47167417
153GABAergic synapse_Homo sapiens_hsa047270.46814617
154Hippo signaling pathway_Homo sapiens_hsa043900.46497015
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46022128
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45410787
157Pathways in cancer_Homo sapiens_hsa052000.45311876
158Fatty acid metabolism_Homo sapiens_hsa012120.44616694
159Phenylalanine metabolism_Homo sapiens_hsa003600.42343774
160Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41887760
161N-Glycan biosynthesis_Homo sapiens_hsa005100.37913566
162Cocaine addiction_Homo sapiens_hsa050300.37043105
163RNA degradation_Homo sapiens_hsa030180.33423748
164HIF-1 signaling pathway_Homo sapiens_hsa040660.32084805
165Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31666314
166Hepatitis B_Homo sapiens_hsa051610.30380059
167FoxO signaling pathway_Homo sapiens_hsa040680.30355910
168Epstein-Barr virus infection_Homo sapiens_hsa051690.29400336

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