TM2D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.08115487
2signal peptide processing (GO:0006465)5.90764616
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.85089847
4ATP synthesis coupled proton transport (GO:0015986)5.73092326
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.73092326
6respiratory electron transport chain (GO:0022904)5.42756437
7electron transport chain (GO:0022900)5.31350601
8protein complex biogenesis (GO:0070271)5.16309449
9regulation of mitochondrial translation (GO:0070129)4.98795455
10proteasome assembly (GO:0043248)4.79208653
11protein maturation by protein folding (GO:0022417)4.68068581
12mitochondrial respiratory chain complex assembly (GO:0033108)4.57873978
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.57114581
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.57114581
15NADH dehydrogenase complex assembly (GO:0010257)4.57114581
16chaperone-mediated protein transport (GO:0072321)4.51427002
17DNA deamination (GO:0045006)4.32033518
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.12485551
19behavioral response to nicotine (GO:0035095)4.08953967
20negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.01700143
21platelet dense granule organization (GO:0060155)3.98162369
22GDP-mannose metabolic process (GO:0019673)3.96325095
23cytochrome complex assembly (GO:0017004)3.95258034
24protein deneddylation (GO:0000338)3.82509175
25oxidative phosphorylation (GO:0006119)3.80329607
26response to misfolded protein (GO:0051788)3.77991366
27respiratory chain complex IV assembly (GO:0008535)3.76002770
28regulation of oxidative phosphorylation (GO:0002082)3.73209675
292-deoxyribonucleotide biosynthetic process (GO:0009265)3.71474225
30deoxyribose phosphate biosynthetic process (GO:0046385)3.71474225
31axoneme assembly (GO:0035082)3.68716480
32GTP biosynthetic process (GO:0006183)3.64163152
33cellular ketone body metabolic process (GO:0046950)3.61693887
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59299350
35protein neddylation (GO:0045116)3.59298189
36guanosine-containing compound biosynthetic process (GO:1901070)3.56947080
37negative regulation of glycoprotein biosynthetic process (GO:0010561)3.55625553
38cullin deneddylation (GO:0010388)3.53089762
39hydrogen ion transmembrane transport (GO:1902600)3.49820181
40Golgi transport vesicle coating (GO:0048200)3.49132333
41COPI coating of Golgi vesicle (GO:0048205)3.49132333
42epithelial cilium movement (GO:0003351)3.43889108
43water-soluble vitamin biosynthetic process (GO:0042364)3.42149325
44L-fucose catabolic process (GO:0042355)3.41221231
45fucose catabolic process (GO:0019317)3.41221231
46L-fucose metabolic process (GO:0042354)3.41221231
47inner mitochondrial membrane organization (GO:0007007)3.36198768
48ketone body metabolic process (GO:1902224)3.28638964
49preassembly of GPI anchor in ER membrane (GO:0016254)3.27558086
50prenylation (GO:0097354)3.23963639
51protein prenylation (GO:0018342)3.23963639
52response to pheromone (GO:0019236)3.22111745
53protein retention in ER lumen (GO:0006621)3.21405464
54mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.20722352
55proton transport (GO:0015992)3.20487545
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18951823
57detection of light stimulus involved in sensory perception (GO:0050962)3.17089117
58detection of light stimulus involved in visual perception (GO:0050908)3.17089117
59nonmotile primary cilium assembly (GO:0035058)3.15980263
60hydrogen transport (GO:0006818)3.14787030
61positive regulation of mitochondrial fission (GO:0090141)3.10570830
62regulation of axon regeneration (GO:0048679)3.10293931
63regulation of neuron projection regeneration (GO:0070570)3.10293931
64deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.09960480
65quinone biosynthetic process (GO:1901663)3.05876301
66ubiquinone biosynthetic process (GO:0006744)3.05876301
67protein targeting to mitochondrion (GO:0006626)3.03985267
68purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03772990
69positive regulation of TOR signaling (GO:0032008)3.02983460
70regulation of glucokinase activity (GO:0033131)3.01869777
71regulation of hexokinase activity (GO:1903299)3.01869777
72photoreceptor cell maintenance (GO:0045494)3.01377501
73purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01021361
74protein localization to cilium (GO:0061512)2.98660775
75establishment of protein localization to mitochondrion (GO:0072655)2.97898934
76ubiquinone metabolic process (GO:0006743)2.96868057
77neural tube formation (GO:0001841)2.95507321
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93339904
79anterograde synaptic vesicle transport (GO:0048490)2.92979489
80cilium movement (GO:0003341)2.92120384
81mannosylation (GO:0097502)2.90505709
82pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87416099
83cilium morphogenesis (GO:0060271)2.87079642
847-methylguanosine mRNA capping (GO:0006370)2.86816155
85protein K11-linked deubiquitination (GO:0035871)2.85520796
86sulfation (GO:0051923)2.85501307
87dopamine transport (GO:0015872)2.84974038
88energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83241650
89ATP hydrolysis coupled proton transport (GO:0015991)2.83241650
90ATP biosynthetic process (GO:0006754)2.82980850
91melanosome transport (GO:0032402)2.82460160
92cilium organization (GO:0044782)2.80250549
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79541372
94aerobic respiration (GO:0009060)2.79534134
95cornea development in camera-type eye (GO:0061303)2.79305876
96CTP biosynthetic process (GO:0006241)2.78765070
97CTP metabolic process (GO:0046036)2.78765070
98protein localization to mitochondrion (GO:0070585)2.78742874
99indolalkylamine metabolic process (GO:0006586)2.78178595
100UTP biosynthetic process (GO:0006228)2.76790195
101metallo-sulfur cluster assembly (GO:0031163)2.76532747
102iron-sulfur cluster assembly (GO:0016226)2.76532747
103negative regulation of glycoprotein metabolic process (GO:1903019)2.76434318
104RNA capping (GO:0036260)2.75728004
1057-methylguanosine RNA capping (GO:0009452)2.75728004
106deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75693338
107kidney morphogenesis (GO:0060993)2.75250831
108intraciliary transport (GO:0042073)2.74887817
109piRNA metabolic process (GO:0034587)2.74782766
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74117157
111cilium assembly (GO:0042384)2.73724456
112establishment of melanosome localization (GO:0032401)2.72847608
113gonadal mesoderm development (GO:0007506)2.72402858
114regulation of cellular amino acid metabolic process (GO:0006521)2.72333238
115GPI anchor metabolic process (GO:0006505)2.71234309
116GMP metabolic process (GO:0046037)2.69672236
117nucleoside diphosphate phosphorylation (GO:0006165)2.69625776
118S-adenosylmethionine metabolic process (GO:0046500)2.68349832
119neuronal action potential (GO:0019228)2.68216954
120indole-containing compound catabolic process (GO:0042436)2.67459525
121indolalkylamine catabolic process (GO:0046218)2.67459525
122tryptophan catabolic process (GO:0006569)2.67459525
123photoreceptor cell development (GO:0042461)2.66557885
124ribonucleoside triphosphate biosynthetic process (GO:0009201)2.64202027
125RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63519381
126pigment granule transport (GO:0051904)2.63446192
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63142232
128positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62703958
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61148104
130neuron fate determination (GO:0048664)2.61100819
131retinal cone cell development (GO:0046549)2.58751414
132adenosine metabolic process (GO:0046085)2.58032422
133regulation of cilium movement (GO:0003352)2.57735805
134mitochondrion morphogenesis (GO:0070584)2.56849137
135mitochondrial transport (GO:0006839)2.56815960
136response to redox state (GO:0051775)2.56437488
137centriole replication (GO:0007099)2.56071918
138adaptation of signaling pathway (GO:0023058)2.55850372
139RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55575718
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55575718
141establishment of pigment granule localization (GO:0051905)2.55134845
142protein-cofactor linkage (GO:0018065)2.55039803
143negative regulation of calcium ion transmembrane transport (GO:1903170)2.53739633
144negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.53739633
145reflex (GO:0060004)2.53613204
146heart process (GO:0003015)2.52896993
147heart contraction (GO:0060047)2.52896993
148C-terminal protein lipidation (GO:0006501)2.52840626
149dopamine biosynthetic process (GO:0042416)2.52505483
150behavioral response to ethanol (GO:0048149)2.52473610
151regulation of type B pancreatic cell apoptotic process (GO:2000674)2.51670528
152negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51555239
153nucleoside triphosphate biosynthetic process (GO:0009142)2.51432424
154positive regulation of prostaglandin secretion (GO:0032308)2.51425642
155negative regulation of cation channel activity (GO:2001258)2.51376345
156UTP metabolic process (GO:0046051)2.50638813
157negative regulation of execution phase of apoptosis (GO:1900118)2.50221554
158misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.49881469
159transferrin transport (GO:0033572)2.49386724
160reciprocal DNA recombination (GO:0035825)2.48998693
161reciprocal meiotic recombination (GO:0007131)2.48998693
162positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.48871610
163nephron tubule morphogenesis (GO:0072078)2.48771421
164nephron epithelium morphogenesis (GO:0072088)2.48771421
165peptidyl-histidine modification (GO:0018202)2.47870316
166auditory receptor cell stereocilium organization (GO:0060088)2.46799242
167C-terminal protein amino acid modification (GO:0018410)2.45784565
168nucleotide transmembrane transport (GO:1901679)2.45512632
169inner ear receptor stereocilium organization (GO:0060122)2.44820076
170keratinocyte development (GO:0003334)2.43705154
171kynurenine metabolic process (GO:0070189)2.42559768
172positive regulation of fatty acid transport (GO:2000193)2.40885924
173positive regulation of meiosis (GO:0045836)2.39511438
174intracellular protein transmembrane import (GO:0044743)2.38300254
175protein import into peroxisome matrix (GO:0016558)2.37152384
176regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35244462
177eye photoreceptor cell development (GO:0042462)2.34504573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.07047492
2* GABP_17652178_ChIP-ChIP_JURKAT_Human3.88527918
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.46237208
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.41529873
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39906432
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26515445
7* VDR_22108803_ChIP-Seq_LS180_Human2.88401403
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83737169
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79355443
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60081052
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.51902476
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51864158
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47669998
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44626427
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.40313439
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.39636399
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.38850105
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26262436
19EWS_26573619_Chip-Seq_HEK293_Human2.16087846
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.14835849
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08100476
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.03918627
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94025572
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88584445
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86980483
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81564580
27IGF1R_20145208_ChIP-Seq_DFB_Human1.79717376
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79320656
29* VDR_23849224_ChIP-Seq_CD4+_Human1.78199681
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74889604
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71930301
32DCP1A_22483619_ChIP-Seq_HELA_Human1.71785826
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65457784
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.64742054
35ELK1_22589737_ChIP-Seq_MCF10A_Human1.61404837
36EZH2_22144423_ChIP-Seq_EOC_Human1.59857671
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58605250
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56465932
39SMAD4_21799915_ChIP-Seq_A2780_Human1.55676290
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55068840
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53504656
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52861386
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52179129
44REST_19997604_ChIP-ChIP_NEURONS_Mouse1.51084434
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50544285
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.50180554
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50085641
48GABP_19822575_ChIP-Seq_HepG2_Human1.48623746
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47876038
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47369848
51GBX2_23144817_ChIP-Seq_PC3_Human1.46634199
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.45273423
53AR_25329375_ChIP-Seq_VCAP_Human1.42045791
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41841572
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41746952
56TAF15_26573619_Chip-Seq_HEK293_Human1.41456988
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.41005264
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40157242
59* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39898581
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39727345
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38974093
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38747894
63* STAT3_23295773_ChIP-Seq_U87_Human1.38237538
64* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36428255
65* TCF4_23295773_ChIP-Seq_U87_Human1.34443623
66ZNF274_21170338_ChIP-Seq_K562_Hela1.34266497
67* ELK1_19687146_ChIP-ChIP_HELA_Human1.34209131
68* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32571601
69MYC_18940864_ChIP-ChIP_HL60_Human1.32402374
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31447270
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.30734546
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29542094
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29016195
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28513819
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.28085192
76TCF4_22108803_ChIP-Seq_LS180_Human1.28044588
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26695139
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25881664
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25774345
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.25667407
81IRF1_19129219_ChIP-ChIP_H3396_Human1.24665820
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24495130
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23642654
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23081809
85* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22687596
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.22137281
87P300_19829295_ChIP-Seq_ESCs_Human1.21228335
88P53_22387025_ChIP-Seq_ESCs_Mouse1.20079958
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19261849
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.19261849
91RNF2_27304074_Chip-Seq_NSC_Mouse1.17924466
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17180203
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16151561
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15776381
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15760299
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14633679
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14602387
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.14292493
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13764846
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13754085
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.12785885
102RUNX2_22187159_ChIP-Seq_PCA_Human1.12039090
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11791654
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11530613
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.10867673
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10606473
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.10578406
108FUS_26573619_Chip-Seq_HEK293_Human1.10221380
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09945109
110GATA1_22025678_ChIP-Seq_K562_Human1.09778802
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09465499
112* TP53_22573176_ChIP-Seq_HFKS_Human1.09317920
113CDX2_22108803_ChIP-Seq_LS180_Human1.09312313
114* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09121516
115* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09006562
116* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08956463
117* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08956463
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08495828
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.08162386
120ERG_20517297_ChIP-Seq_VCAP_Human1.07194084
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06397515
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.05557296
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04426919
124* NANOG_19829295_ChIP-Seq_ESCs_Human1.04414354
125* SOX2_19829295_ChIP-Seq_ESCs_Human1.04414354
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04222104
127TAL1_26923725_Chip-Seq_HPCs_Mouse1.04088029
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03555479
129NCOR_22424771_ChIP-Seq_293T_Human1.03072206
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02426319
131MYC_18555785_ChIP-Seq_MESCs_Mouse1.00799820
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00165800
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00030610
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99985202
135* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99191131
136SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99015724
137YY1_21170310_ChIP-Seq_MESCs_Mouse0.98881009
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96929215
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96892110
140EZH2_27304074_Chip-Seq_ESCs_Mouse0.95696144
141SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92994733
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91989485
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91850175
144MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91205394
145JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91124985
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90893448
147NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90860240
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90733203
149CBP_20019798_ChIP-Seq_JUKART_Human0.90315604
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90315604
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90216137
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89700584
153EED_16625203_ChIP-ChIP_MESCs_Mouse0.88434063
154ER_23166858_ChIP-Seq_MCF-7_Human0.88039669
155BCAT_22108803_ChIP-Seq_LS180_Human0.87639040
156* FOXP3_21729870_ChIP-Seq_TREG_Human0.86633671
157CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86239388
158HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85399586
159AR_20517297_ChIP-Seq_VCAP_Human0.84855528
160CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83610327
161* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82285397
162JUN_21703547_ChIP-Seq_K562_Human0.82122185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.61296911
2MP0003646_muscle_fatigue3.10678084
3MP0006276_abnormal_autonomic_nervous2.96784737
4MP0003195_calcinosis2.80955459
5MP0001188_hyperpigmentation2.79827956
6MP0004043_abnormal_pH_regulation2.79826025
7MP0010386_abnormal_urinary_bladder2.79701015
8MP0003880_abnormal_central_pattern2.67029695
9MP0008877_abnormal_DNA_methylation2.63626129
10MP0002837_dystrophic_cardiac_calcinosis2.49366051
11MP0002102_abnormal_ear_morphology2.42014635
12MP0005084_abnormal_gallbladder_morpholo2.35456366
13MP0001905_abnormal_dopamine_level2.35331879
14MP0002909_abnormal_adrenal_gland2.32140996
15MP0000013_abnormal_adipose_tissue2.27536837
16MP0009046_muscle_twitch2.25315993
17MP0001529_abnormal_vocalization2.22596329
18MP0009379_abnormal_foot_pigmentation2.17982197
19MP0005379_endocrine/exocrine_gland_phen2.09214826
20MP0005174_abnormal_tail_pigmentation2.07021076
21MP0002734_abnormal_mechanical_nocicepti2.00728661
22MP0003011_delayed_dark_adaptation2.00594696
23MP0006036_abnormal_mitochondrial_physio1.99287442
24MP0002938_white_spotting1.96591573
25MP0001984_abnormal_olfaction1.95140821
26MP0001986_abnormal_taste_sensitivity1.94536303
27MP0005646_abnormal_pituitary_gland1.87590394
28MP0002638_abnormal_pupillary_reflex1.87442502
29MP0006292_abnormal_olfactory_placode1.75277962
30MP0002163_abnormal_gland_morphology1.74076731
31MP0002693_abnormal_pancreas_physiology1.70742354
32MP0003186_abnormal_redox_activity1.64231106
33MP0005408_hypopigmentation1.58913529
34MP0004142_abnormal_muscle_tone1.58297463
35MP0002735_abnormal_chemical_nociception1.55160387
36MP0008875_abnormal_xenobiotic_pharmacok1.50848916
37MP0003787_abnormal_imprinting1.49464922
38MP0002733_abnormal_thermal_nociception1.48856521
39MP0002653_abnormal_ependyma_morphology1.48161176
40MP0004270_analgesia1.47071147
41MP0004885_abnormal_endolymph1.47006968
42MP0001970_abnormal_pain_threshold1.45115368
43MP0000427_abnormal_hair_cycle1.44753930
44MP0001968_abnormal_touch/_nociception1.44463443
45MP0001944_abnormal_pancreas_morphology1.44442150
46MP0005636_abnormal_mineral_homeostasis1.41983567
47MP0000372_irregular_coat_pigmentation1.40818248
48MP0004145_abnormal_muscle_electrophysio1.40381726
49MP0006072_abnormal_retinal_apoptosis1.36950892
50MP0002272_abnormal_nervous_system1.36169351
51MP0000749_muscle_degeneration1.35396110
52MP0005075_abnormal_melanosome_morpholog1.32736453
53MP0004215_abnormal_myocardial_fiber1.32334025
54MP0002095_abnormal_skin_pigmentation1.32249568
55MP0005220_abnormal_exocrine_pancreas1.32240541
56MP0001486_abnormal_startle_reflex1.30615662
57MP0002736_abnormal_nociception_after1.29841774
58MP0003329_amyloid_beta_deposits1.29310753
59MP0002876_abnormal_thyroid_physiology1.28249054
60MP0005058_abnormal_lysosome_morphology1.26722738
61MP0001502_abnormal_circadian_rhythm1.26173267
62MP0008872_abnormal_physiological_respon1.24657089
63MP0002160_abnormal_reproductive_system1.24402746
64MP0005645_abnormal_hypothalamus_physiol1.23721973
65MP0002928_abnormal_bile_duct1.21427064
66MP0000678_abnormal_parathyroid_gland1.21324190
67MP0001485_abnormal_pinna_reflex1.21182383
68MP0000230_abnormal_systemic_arterial1.21115474
69MP0003724_increased_susceptibility_to1.20807767
70MP0005535_abnormal_body_temperature1.20616268
71MP0003183_abnormal_peptide_metabolism1.19809083
72MP0005171_absent_coat_pigmentation1.19679650
73MP0002234_abnormal_pharynx_morphology1.18648572
74MP0005389_reproductive_system_phenotype1.16224704
75MP0000383_abnormal_hair_follicle1.15023128
76MP0001542_abnormal_bone_strength1.14726029
77MP0006035_abnormal_mitochondrial_morpho1.12555641
78MP0005551_abnormal_eye_electrophysiolog1.12522903
79MP0005085_abnormal_gallbladder_physiolo1.10172236
80MP0008995_early_reproductive_senescence1.09244445
81MP0004036_abnormal_muscle_relaxation1.06918888
82MP0003806_abnormal_nucleotide_metabolis1.05957872
83MP0004484_altered_response_of1.05743141
84MP0003122_maternal_imprinting1.04952310
85MP0004133_heterotaxia1.03628102
86MP0002184_abnormal_innervation1.03257184
87MP0003635_abnormal_synaptic_transmissio1.02988152
88MP0009697_abnormal_copulation1.02072761
89MP0003879_abnormal_hair_cell1.02019008
90MP0005332_abnormal_amino_acid1.01931494
91MP0000538_abnormal_urinary_bladder1.00327692
92MP0002557_abnormal_social/conspecific_i1.00179423
93MP0009745_abnormal_behavioral_response0.99890231
94MP0004924_abnormal_behavior0.99077467
95MP0005386_behavior/neurological_phenoty0.99077467
96MP0003718_maternal_effect0.98857938
97MP0003136_yellow_coat_color0.98592118
98MP0002277_abnormal_respiratory_mucosa0.98116160
99MP0001756_abnormal_urination0.98066205
100MP0009643_abnormal_urine_homeostasis0.97625278
101MP0000681_abnormal_thyroid_gland0.97551293
102MP0005365_abnormal_bile_salt0.97126841
103MP0001324_abnormal_eye_pigmentation0.96510340
104MP0005410_abnormal_fertilization0.96135876
105MP0000631_abnormal_neuroendocrine_gland0.95607768
106MP0002064_seizures0.95350285
107MP0002877_abnormal_melanocyte_morpholog0.94019947
108MP0000647_abnormal_sebaceous_gland0.93881875
109MP0001765_abnormal_ion_homeostasis0.92913223
110MP0004742_abnormal_vestibular_system0.92215373
111MP0000015_abnormal_ear_pigmentation0.92202094
112MP0003283_abnormal_digestive_organ0.90220241
113MP0005195_abnormal_posterior_eye0.90026254
114MP0002332_abnormal_exercise_endurance0.89818849
115MP0002078_abnormal_glucose_homeostasis0.89464638
116MP0005253_abnormal_eye_physiology0.88852032
117MP0002295_abnormal_pulmonary_circulatio0.88833313
118MP0005165_increased_susceptibility_to0.87006299
119MP0010329_abnormal_lipoprotein_level0.86811514
120MP0005367_renal/urinary_system_phenotyp0.86763808
121MP0000516_abnormal_urinary_system0.86763808
122MP0002090_abnormal_vision0.84694605
123MP0002067_abnormal_sensory_capabilities0.82993711
124MP0008789_abnormal_olfactory_epithelium0.81985826
125MP0001664_abnormal_digestion0.81858652
126MP0004859_abnormal_synaptic_plasticity0.80812334
127MP0001764_abnormal_homeostasis0.80568773
128MP0002572_abnormal_emotion/affect_behav0.80400558
129MP0008058_abnormal_DNA_repair0.79149844
130MP0002972_abnormal_cardiac_muscle0.78828145
131MP0002751_abnormal_autonomic_nervous0.76867083
132MP0002229_neurodegeneration0.76650472
133MP0009780_abnormal_chondrocyte_physiolo0.75778508
134MP0001501_abnormal_sleep_pattern0.75771689
135MP0000955_abnormal_spinal_cord0.75560586
136MP0003959_abnormal_lean_body0.74295295
137MP0002063_abnormal_learning/memory/cond0.74090494
138MP0000639_abnormal_adrenal_gland0.73767080
139MP0005391_vision/eye_phenotype0.73050461
140MP0002138_abnormal_hepatobiliary_system0.71439409
141MP0008260_abnormal_autophagy0.71172126
142MP0004147_increased_porphyrin_level0.71000163
143MP0001879_abnormal_lymphatic_vessel0.69898173
144MP0000462_abnormal_digestive_system0.69611913
145MP0004858_abnormal_nervous_system0.69328952
146MP0001270_distended_abdomen0.68880462
147MP0005595_abnormal_vascular_smooth0.66704752

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.83398488
2Abnormal mitochondria in muscle tissue (HP:0008316)5.59141408
3Acute encephalopathy (HP:0006846)4.95567102
4Mitochondrial inheritance (HP:0001427)4.92228031
5Progressive macrocephaly (HP:0004481)4.69429865
6Hepatocellular necrosis (HP:0001404)4.41832490
7Hepatic necrosis (HP:0002605)4.40861552
8Increased CSF lactate (HP:0002490)4.34168120
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.96578349
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.96578349
11Molar tooth sign on MRI (HP:0002419)3.85753312
12Abnormality of midbrain morphology (HP:0002418)3.85753312
13Nephronophthisis (HP:0000090)3.58758437
14Abnormality of the renal cortex (HP:0011035)3.45831127
15Lipid accumulation in hepatocytes (HP:0006561)3.38838557
16Increased hepatocellular lipid droplets (HP:0006565)3.36932959
17Congenital stationary night blindness (HP:0007642)3.34651585
18Generalized aminoaciduria (HP:0002909)3.29547717
19Lactic acidosis (HP:0003128)3.25826866
20Pheochromocytoma (HP:0002666)3.24548578
21Abnormality of the renal medulla (HP:0100957)3.20435759
22Retinal dysplasia (HP:0007973)3.19165686
23Hypothermia (HP:0002045)3.16083932
24Neuroendocrine neoplasm (HP:0100634)3.09603368
25Increased intramyocellular lipid droplets (HP:0012240)3.08303584
26Cerebral edema (HP:0002181)3.06556910
27Respiratory failure (HP:0002878)3.05379563
28Exercise intolerance (HP:0003546)2.97263893
29Optic disc pallor (HP:0000543)2.96811271
30Attenuation of retinal blood vessels (HP:0007843)2.96201764
31Renal Fanconi syndrome (HP:0001994)2.95422605
32Abnormal protein glycosylation (HP:0012346)2.92979048
33Abnormal glycosylation (HP:0012345)2.92979048
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92979048
35Abnormal protein N-linked glycosylation (HP:0012347)2.92979048
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92118349
37Type I transferrin isoform profile (HP:0003642)2.88493504
38Symptomatic seizures (HP:0011145)2.87341784
39Increased muscle lipid content (HP:0009058)2.87073576
40Tubular atrophy (HP:0000092)2.79363166
41Renal cortical cysts (HP:0000803)2.77899810
42Abnormality of alanine metabolism (HP:0010916)2.74989032
43Hyperalaninemia (HP:0003348)2.74989032
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74989032
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74311869
46Hypoglycemic seizures (HP:0002173)2.71456742
47Abnormal drinking behavior (HP:0030082)2.70201398
48Polydipsia (HP:0001959)2.70201398
49Chronic hepatic failure (HP:0100626)2.69053841
50Gaze-evoked nystagmus (HP:0000640)2.68751506
513-Methylglutaconic aciduria (HP:0003535)2.68751337
52Medial flaring of the eyebrow (HP:0010747)2.67249832
53Increased serum lactate (HP:0002151)2.63468178
54Cystic liver disease (HP:0006706)2.59074821
55Hypoglycemic coma (HP:0001325)2.58349159
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58043276
57Abolished electroretinogram (ERG) (HP:0000550)2.50427528
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49815426
59Hyperphosphaturia (HP:0003109)2.48432905
60Type II lissencephaly (HP:0007260)2.48140836
61Fair hair (HP:0002286)2.45628252
62Increased serum pyruvate (HP:0003542)2.42841821
63Abnormality of glycolysis (HP:0004366)2.42841821
64Abnormality of magnesium homeostasis (HP:0004921)2.41777251
65Methylmalonic acidemia (HP:0002912)2.39624208
66Ketoacidosis (HP:0001993)2.38824047
67Furrowed tongue (HP:0000221)2.38384307
68Large for gestational age (HP:0001520)2.38198179
69Increased corneal curvature (HP:0100692)2.38044470
70Keratoconus (HP:0000563)2.38044470
71Abnormality of urine glucose concentration (HP:0011016)2.36292826
72Glycosuria (HP:0003076)2.36292826
73Irregular epiphyses (HP:0010582)2.33775673
74Abnormality of renal resorption (HP:0011038)2.31926764
75Gait imbalance (HP:0002141)2.31898144
76Congenital primary aphakia (HP:0007707)2.30376447
77Congenital, generalized hypertrichosis (HP:0004540)2.27526312
78Leukodystrophy (HP:0002415)2.26955740
79Progressive neurologic deterioration (HP:0002344)2.25418152
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.23916554
81Decreased central vision (HP:0007663)2.22662205
82Nephrogenic diabetes insipidus (HP:0009806)2.18743918
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18196362
84Exertional dyspnea (HP:0002875)2.17510178
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.16836215
86Hyperinsulinemic hypoglycemia (HP:0000825)2.16562345
87Vacuolated lymphocytes (HP:0001922)2.16078603
88Split foot (HP:0001839)2.16025338
89Abnormal biliary tract physiology (HP:0012439)2.15518219
90Bile duct proliferation (HP:0001408)2.15518219
91Reduced antithrombin III activity (HP:0001976)2.15370256
92Hypomagnesemia (HP:0002917)2.13787288
93Pendular nystagmus (HP:0012043)2.13603292
94Sclerocornea (HP:0000647)2.10030199
95Congenital hepatic fibrosis (HP:0002612)2.09776252
96Intestinal atresia (HP:0011100)2.09220249
97Polyuria (HP:0000103)2.08488320
98Hemiparesis (HP:0001269)2.08021985
99Irregular vertebral endplates (HP:0003301)2.07615398
100Flat capital femoral epiphysis (HP:0003370)2.07024718
101X-linked dominant inheritance (HP:0001423)2.06570652
102Lethargy (HP:0001254)2.05584335
103Inability to walk (HP:0002540)2.04713265
104Febrile seizures (HP:0002373)2.04075991
105Abnormality of calcium-phosphate metabolism (HP:0100530)2.01556800
106Abnormal respiratory motile cilium morphology (HP:0005938)1.99999653
107Abnormal respiratory epithelium morphology (HP:0012253)1.99999653
108Focal motor seizures (HP:0011153)1.99878293
109Absent speech (HP:0001344)1.99419179
110Pancreatic fibrosis (HP:0100732)1.99416600
111Abnormal ciliary motility (HP:0012262)1.99333542
112Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98599893
113Aplasia/hypoplasia of the uterus (HP:0008684)1.98314396
114Delayed epiphyseal ossification (HP:0002663)1.96526925
115Cerebellar dysplasia (HP:0007033)1.96141391
116Methylmalonic aciduria (HP:0012120)1.95754955
117Anencephaly (HP:0002323)1.93650348
118CNS demyelination (HP:0007305)1.93205616
119Postaxial hand polydactyly (HP:0001162)1.92156218
120Postaxial foot polydactyly (HP:0001830)1.92053502
121Delusions (HP:0000746)1.91748361
122Male pseudohermaphroditism (HP:0000037)1.91588307
123Poor suck (HP:0002033)1.91355893
124Vaginal atresia (HP:0000148)1.90995776
125Progressive cerebellar ataxia (HP:0002073)1.90330456
126Ketosis (HP:0001946)1.90197370
127Short tibia (HP:0005736)1.89922136
128Abnormal respiratory motile cilium physiology (HP:0012261)1.88676765
129Emotional lability (HP:0000712)1.88461219
130Broad-based gait (HP:0002136)1.88324340
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88081413
132Stomach cancer (HP:0012126)1.86961181
133Congenital sensorineural hearing impairment (HP:0008527)1.86623743
134Genital tract atresia (HP:0001827)1.85923230
135Concave nail (HP:0001598)1.85137845
136True hermaphroditism (HP:0010459)1.84062664
137Absent/shortened dynein arms (HP:0200106)1.83310885
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.83310885
139Progressive inability to walk (HP:0002505)1.82907088
140Renal tubular dysfunction (HP:0000124)1.82077177
141Rhinitis (HP:0012384)1.80898390
142Abnormal urine phosphate concentration (HP:0012599)1.80879651
143Generalized hypopigmentation of hair (HP:0011358)1.80060658
144Abnormality of the vertebral endplates (HP:0005106)1.79593273
145Bony spicule pigmentary retinopathy (HP:0007737)1.78486319
146Proximal tubulopathy (HP:0000114)1.76987932
147Abnormality of the fovea (HP:0000493)1.76602113
148Abnormality of vitamin B metabolism (HP:0004340)1.76435537
149Respiratory difficulties (HP:0002880)1.75691003
150Ragged-red muscle fibers (HP:0003200)1.75065296
151Abnormal tarsal ossification (HP:0008369)1.74477515
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71686903
153Dicarboxylic aciduria (HP:0003215)1.71686903
154Esotropia (HP:0000565)1.71234417
155Abnormal pancreas size (HP:0012094)1.69541070
156Unsteady gait (HP:0002317)1.68943171
157Abnormality of fatty-acid metabolism (HP:0004359)1.68912080
158Pancreatic cysts (HP:0001737)1.68436590
159Decreased circulating renin level (HP:0003351)1.63662167
160Hyperactive renin-angiotensin system (HP:0000841)1.62423833
161Abnormal rod and cone electroretinograms (HP:0008323)1.61439350
162Hyperventilation (HP:0002883)1.60350263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.49930052
2ARAF3.76008730
3NME13.35111016
4STK163.29673198
5CDK193.23978091
6MAP3K123.19718656
7MAP4K22.59533866
8BMPR22.52055236
9PBK2.45125085
10NUAK12.37736139
11MAP3K42.08496137
12EIF2AK32.01026324
13GRK11.95415164
14BCKDK1.94096113
15MAP2K71.89925338
16WNK41.85756125
17BCR1.69656904
18IRAK11.69414620
19PINK11.67085993
20TRIM281.60317767
21TAOK31.57440750
22CAMKK21.52947445
23INSRR1.50389817
24BRAF1.48712101
25MUSK1.48649663
26ACVR1B1.45047464
27RIPK41.42667455
28KSR21.42001060
29BUB11.41327286
30CDK81.38509686
31MOS1.35743939
32WNK31.35501035
33STK38L1.31834057
34PIM21.31304067
35TLK11.31078209
36BMPR1B1.30676132
37MKNK21.28047606
38MYLK1.27357598
39LIMK11.24831293
40DYRK21.21338026
41MAP3K21.18509185
42CSNK1G21.18306058
43NTRK31.16345429
44MAPK151.15420411
45STK241.13308367
46CSNK1G11.13001779
47CASK1.12448499
48STK391.07745336
49KDR1.06111427
50DYRK31.04773948
51CAMK2D1.00290579
52MAP3K131.00093687
53TESK20.99549839
54NME20.99086137
55FGFR20.98970429
56CAMK2B0.97782224
57TNIK0.97533511
58MINK10.95824872
59EIF2AK10.95740858
60GRK70.95579513
61ADRBK10.94589697
62DAPK20.93453707
63VRK10.92862808
64ERBB30.91994240
65CCNB10.90261367
66MAPK130.90050374
67MARK10.89184898
68NTRK10.87514572
69CSNK1A1L0.86459202
70RAF10.85155985
71IRAK30.84414889
72MAP3K110.82723866
73MST40.81181363
74IRAK40.80618958
75TXK0.79763221
76PRKCG0.78915153
77OXSR10.77861458
78IRAK20.76901185
79TGFBR10.76091812
80ABL20.75405467
81CAMK2G0.75101521
82PASK0.74949113
83MAP3K90.74631763
84PNCK0.74316628
85EPHA40.74143784
86STK30.73584691
87CAMK2A0.71937024
88OBSCN0.71038094
89ADRBK20.70952807
90PTK2B0.70919907
91GRK50.70895202
92HIPK20.70090704
93PHKG20.69122219
94PHKG10.69122219
95RPS6KA50.68329441
96PLK30.67541227
97TEC0.67308732
98KSR10.66069470
99IKBKB0.66058940
100MAPKAPK50.65812722
101PIK3CA0.65344998
102PLK40.64579616
103MKNK10.63911044
104ZAK0.63907000
105PIK3CG0.63455675
106MAP2K10.62834499
107MAP3K10.62320090
108VRK20.61839181
109PDK20.60606057
110SIK30.59696439
111NLK0.55430311
112FER0.54785292
113ERBB40.54573032
114SCYL20.51807268
115PRKCE0.50991711
116PLK20.50854547
117KIT0.50491050
118MAP2K40.50459985
119PRKD30.49077401
120CSNK1G30.49042357
121PAK30.48461386
122DYRK1A0.47897327
123PRKCQ0.47385197
124TBK10.47100211
125TESK10.46935377
126PRKACA0.46585520
127ZAP700.46062244
128MAPKAPK30.44786107
129PRKG20.43752764
130BRSK20.43544555
131EPHA30.43448596
132UHMK10.42503833
133TIE10.42366567
134PKN10.42042927
135FLT30.41933376
136IKBKE0.41677195
137PRKG10.41599274
138DAPK30.41583751
139RPS6KA40.40672992
140YES10.40407059
141MAP2K60.38098263
142CSNK1A10.38098063
143CAMK10.37254076
144STK110.36353347
145CSNK1D0.36250926
146PRKACB0.33230462
147ABL10.32685453
148TNK20.31514669
149PRKAA20.30951311

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.54452637
2Oxidative phosphorylation_Homo sapiens_hsa001905.40980525
3Parkinsons disease_Homo sapiens_hsa050124.54992512
4Alzheimers disease_Homo sapiens_hsa050103.47110350
5Huntingtons disease_Homo sapiens_hsa050163.22328978
6Proteasome_Homo sapiens_hsa030503.01741261
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.91333134
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.80061563
9Nitrogen metabolism_Homo sapiens_hsa009102.71416945
10Sulfur metabolism_Homo sapiens_hsa009202.51401554
11Collecting duct acid secretion_Homo sapiens_hsa049662.18735482
12Folate biosynthesis_Homo sapiens_hsa007902.13074970
13Cardiac muscle contraction_Homo sapiens_hsa042602.10657199
14Vibrio cholerae infection_Homo sapiens_hsa051102.00960677
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96749191
16RNA polymerase_Homo sapiens_hsa030201.89489806
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77945550
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75278478
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64732729
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62057455
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60077210
22Ribosome_Homo sapiens_hsa030101.56762135
23Selenocompound metabolism_Homo sapiens_hsa004501.51326858
24Regulation of autophagy_Homo sapiens_hsa041401.44375206
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.42187282
26Homologous recombination_Homo sapiens_hsa034401.39128514
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37551693
28Synaptic vesicle cycle_Homo sapiens_hsa047211.37318519
29Fatty acid elongation_Homo sapiens_hsa000621.31557886
30Tryptophan metabolism_Homo sapiens_hsa003801.31030489
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24044019
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21298168
33Fanconi anemia pathway_Homo sapiens_hsa034601.20242617
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19559326
35N-Glycan biosynthesis_Homo sapiens_hsa005101.18146884
36Caffeine metabolism_Homo sapiens_hsa002321.16232204
37Pyrimidine metabolism_Homo sapiens_hsa002401.07537710
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.03465466
39Chemical carcinogenesis_Homo sapiens_hsa052041.01245042
40Rheumatoid arthritis_Homo sapiens_hsa053230.98655290
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95313797
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94324964
43Olfactory transduction_Homo sapiens_hsa047400.91728475
44Insulin secretion_Homo sapiens_hsa049110.90537463
45Serotonergic synapse_Homo sapiens_hsa047260.90050141
46ABC transporters_Homo sapiens_hsa020100.88183262
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88017986
48Retinol metabolism_Homo sapiens_hsa008300.87815137
49Other glycan degradation_Homo sapiens_hsa005110.86247580
50Phototransduction_Homo sapiens_hsa047440.85679028
51Metabolic pathways_Homo sapiens_hsa011000.85653441
52Sphingolipid metabolism_Homo sapiens_hsa006000.85378254
53Type I diabetes mellitus_Homo sapiens_hsa049400.84434458
54Pyruvate metabolism_Homo sapiens_hsa006200.82497230
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81418068
56Sulfur relay system_Homo sapiens_hsa041220.80892238
57One carbon pool by folate_Homo sapiens_hsa006700.79314071
58Purine metabolism_Homo sapiens_hsa002300.78883450
59Taste transduction_Homo sapiens_hsa047420.77248957
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.77046501
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75894120
62Propanoate metabolism_Homo sapiens_hsa006400.72893522
63GABAergic synapse_Homo sapiens_hsa047270.72625768
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72498206
65Nicotine addiction_Homo sapiens_hsa050330.72019143
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71549326
67Peroxisome_Homo sapiens_hsa041460.70490570
68Non-homologous end-joining_Homo sapiens_hsa034500.66142791
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66069685
70Circadian rhythm_Homo sapiens_hsa047100.65392969
71beta-Alanine metabolism_Homo sapiens_hsa004100.64470296
72Steroid biosynthesis_Homo sapiens_hsa001000.64097298
73Asthma_Homo sapiens_hsa053100.63856876
74Basal transcription factors_Homo sapiens_hsa030220.63452063
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63413215
76Lysosome_Homo sapiens_hsa041420.63294538
77Dopaminergic synapse_Homo sapiens_hsa047280.63157207
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60117808
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59779589
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59405735
81Pancreatic secretion_Homo sapiens_hsa049720.56490377
82Galactose metabolism_Homo sapiens_hsa000520.56391235
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55398242
84Ovarian steroidogenesis_Homo sapiens_hsa049130.54604532
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53797929
86Phagosome_Homo sapiens_hsa041450.52751911
87Prion diseases_Homo sapiens_hsa050200.52091940
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50871846
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50403195
90Dorso-ventral axis formation_Homo sapiens_hsa043200.48570845
91Butanoate metabolism_Homo sapiens_hsa006500.48524703
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48507060
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47734189
94Circadian entrainment_Homo sapiens_hsa047130.47679016
95Salivary secretion_Homo sapiens_hsa049700.47453475
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47018769
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46875186
98Glutathione metabolism_Homo sapiens_hsa004800.44774199
99Amphetamine addiction_Homo sapiens_hsa050310.44272322
100Arginine and proline metabolism_Homo sapiens_hsa003300.43956972
101Cocaine addiction_Homo sapiens_hsa050300.42539025
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42147560
103Fructose and mannose metabolism_Homo sapiens_hsa000510.39956056
104Vitamin digestion and absorption_Homo sapiens_hsa049770.39538123
105Long-term potentiation_Homo sapiens_hsa047200.39462630
106Mineral absorption_Homo sapiens_hsa049780.39428650
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37486150
108RNA degradation_Homo sapiens_hsa030180.35193238
109Morphine addiction_Homo sapiens_hsa050320.35016008
110African trypanosomiasis_Homo sapiens_hsa051430.34811005
111Calcium signaling pathway_Homo sapiens_hsa040200.34333237
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33327974
113Carbon metabolism_Homo sapiens_hsa012000.32720566
114Fatty acid metabolism_Homo sapiens_hsa012120.32679864
115Arachidonic acid metabolism_Homo sapiens_hsa005900.32280508
116Long-term depression_Homo sapiens_hsa047300.31333202
117Histidine metabolism_Homo sapiens_hsa003400.30641305
118Ether lipid metabolism_Homo sapiens_hsa005650.29450240
119Primary immunodeficiency_Homo sapiens_hsa053400.29205943
120Cholinergic synapse_Homo sapiens_hsa047250.28639763
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27972343
122Starch and sucrose metabolism_Homo sapiens_hsa005000.27347779
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27279824
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27041586
125Glutamatergic synapse_Homo sapiens_hsa047240.26234397
126Fat digestion and absorption_Homo sapiens_hsa049750.25689175
127Fatty acid degradation_Homo sapiens_hsa000710.25333616
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.24531493
129Alcoholism_Homo sapiens_hsa050340.23107463
130Renin-angiotensin system_Homo sapiens_hsa046140.21091674
131Malaria_Homo sapiens_hsa051440.18798077
132Thyroid cancer_Homo sapiens_hsa052160.16471447
133Pentose phosphate pathway_Homo sapiens_hsa000300.11211004
134Nucleotide excision repair_Homo sapiens_hsa034200.10918468
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10105531
136Linoleic acid metabolism_Homo sapiens_hsa005910.09746702

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