TM2D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.43766936
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.06167935
3axon ensheathment in central nervous system (GO:0032291)4.86924409
4central nervous system myelination (GO:0022010)4.86924409
5fatty acid elongation (GO:0030497)4.65414256
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.63942092
7protein maturation by protein folding (GO:0022417)4.59085132
8presynaptic membrane organization (GO:0097090)4.57248240
9ATP synthesis coupled proton transport (GO:0015986)4.45555387
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.45555387
11protein neddylation (GO:0045116)4.28043172
12presynaptic membrane assembly (GO:0097105)4.25119020
13chaperone-mediated protein transport (GO:0072321)4.21278611
14respiratory electron transport chain (GO:0022904)4.16181544
15electron transport chain (GO:0022900)4.06177327
16signal peptide processing (GO:0006465)4.03184819
17regulation of integrin-mediated signaling pathway (GO:2001044)4.03083097
18protein complex biogenesis (GO:0070271)4.01148249
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89402056
20regulation of cellular amino acid metabolic process (GO:0006521)3.88666746
21platelet dense granule organization (GO:0060155)3.81688728
22negative regulation of ligase activity (GO:0051352)3.73488165
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.73488165
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70441945
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.70441945
26NADH dehydrogenase complex assembly (GO:0010257)3.70441945
27mannosylation (GO:0097502)3.67124726
28long-chain fatty acid biosynthetic process (GO:0042759)3.64539223
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61537169
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.54713465
31nucleotide transmembrane transport (GO:1901679)3.50283411
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.50230281
33mitochondrial respiratory chain complex assembly (GO:0033108)3.47542277
34respiratory chain complex IV assembly (GO:0008535)3.35777211
35negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.28264301
36cullin deneddylation (GO:0010388)3.27133298
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21449463
38protein deneddylation (GO:0000338)3.20683559
39negative regulation of neurotransmitter secretion (GO:0046929)3.14941655
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13058088
41viral protein processing (GO:0019082)3.11034020
42cell adhesion mediated by integrin (GO:0033627)3.08891246
43cytochrome complex assembly (GO:0017004)3.03902095
44extracellular fibril organization (GO:0043206)3.03496622
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01860152
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.01825519
47ATP hydrolysis coupled proton transport (GO:0015991)3.01825519
48hydrogen ion transmembrane transport (GO:1902600)3.01453341
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00199218
50signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00199218
51negative regulation of neurotransmitter transport (GO:0051589)2.99537240
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97830700
53regulation of cellular amine metabolic process (GO:0033238)2.97760212
54lipopolysaccharide biosynthetic process (GO:0009103)2.97571385
55polyamine biosynthetic process (GO:0006596)2.96884380
56de novo protein folding (GO:0006458)2.96735648
57endothelium development (GO:0003158)2.96702132
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96310679
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96310679
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96310679
61cyclooxygenase pathway (GO:0019371)2.93230127
62aldehyde catabolic process (GO:0046185)2.90281275
63response to redox state (GO:0051775)2.89919598
64phagosome maturation (GO:0090382)2.89240224
65positive regulation of ligase activity (GO:0051351)2.88950487
66antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88906083
67proton transport (GO:0015992)2.88068173
68ribosome assembly (GO:0042255)2.85758700
69hydrogen transport (GO:0006818)2.83513762
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.83443849
71substantia nigra development (GO:0021762)2.82803188
72signal transduction involved in DNA damage checkpoint (GO:0072422)2.81925171
73signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81925171
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81174552
75regulation of ubiquitin-protein transferase activity (GO:0051438)2.80703276
76transferrin transport (GO:0033572)2.77835543
77neuron cell-cell adhesion (GO:0007158)2.75527401
78signal transduction involved in cell cycle checkpoint (GO:0072395)2.74508978
79cellular response to arsenic-containing substance (GO:0071243)2.74453791
80cholesterol biosynthetic process (GO:0006695)2.73505341
81GPI anchor biosynthetic process (GO:0006506)2.73110016
82establishment of integrated proviral latency (GO:0075713)2.72718433
83oligodendrocyte differentiation (GO:0048709)2.72604515
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.70727769
85L-phenylalanine catabolic process (GO:0006559)2.70727769
86regulation of ligase activity (GO:0051340)2.70712667
87COPI coating of Golgi vesicle (GO:0048205)2.69966625
88Golgi transport vesicle coating (GO:0048200)2.69966625
89regulation of autophagic vacuole assembly (GO:2000785)2.68261316
90fibril organization (GO:0097435)2.66413959
91de novo posttranslational protein folding (GO:0051084)2.66117016
92glutathione biosynthetic process (GO:0006750)2.63541622
93cell redox homeostasis (GO:0045454)2.63424497
94thrombin receptor signaling pathway (GO:0070493)2.63310574
95myelination (GO:0042552)2.59949889
96purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.59854863
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.59854863
98establishment of viral latency (GO:0019043)2.59592485
99dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.59369631
100amyloid precursor protein catabolic process (GO:0042987)2.58937127
101ferric iron transport (GO:0015682)2.57259169
102trivalent inorganic cation transport (GO:0072512)2.57259169
103nonribosomal peptide biosynthetic process (GO:0019184)2.56485439
104positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.55559379
105regulation of cytokine secretion involved in immune response (GO:0002739)2.55247233
106DNA double-strand break processing (GO:0000729)2.55160224
107nucleotide-sugar biosynthetic process (GO:0009226)2.55071356
108negative regulation of protein ubiquitination (GO:0031397)2.54630534
109GPI anchor metabolic process (GO:0006505)2.54414319
110ensheathment of neurons (GO:0007272)2.53504054
111axon ensheathment (GO:0008366)2.53504054
112negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.53359164
113negative regulation of platelet activation (GO:0010544)2.52682167
114amyloid precursor protein metabolic process (GO:0042982)2.48764767
115membrane assembly (GO:0071709)2.48061198
116sterol biosynthetic process (GO:0016126)2.47141509
117pH reduction (GO:0045851)2.46982903
118glycerophospholipid catabolic process (GO:0046475)2.46930118
119magnesium ion transport (GO:0015693)2.46328448
120polyamine metabolic process (GO:0006595)2.43705408
121ATP biosynthetic process (GO:0006754)2.43289098
122protein targeting to mitochondrion (GO:0006626)2.41305841
123negative regulation of mitochondrion organization (GO:0010823)2.41267662
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.41101668
125termination of RNA polymerase III transcription (GO:0006386)2.41101668
126regulation of mononuclear cell migration (GO:0071675)2.41039925
127lipopolysaccharide metabolic process (GO:0008653)2.40701786
128copper ion homeostasis (GO:0055070)2.39810803
129very long-chain fatty acid metabolic process (GO:0000038)2.39547100
130positive regulation of mitochondrial fission (GO:0090141)2.39536809
131purine nucleoside triphosphate biosynthetic process (GO:0009145)2.39372483
132purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.39229566
133isoprenoid biosynthetic process (GO:0008299)2.38730213
134regulation of catecholamine metabolic process (GO:0042069)2.38604801
135regulation of dopamine metabolic process (GO:0042053)2.38604801
136regulation of protein targeting to membrane (GO:0090313)2.38429561
137cellular copper ion homeostasis (GO:0006878)2.38202657
138RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37618679
139tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37618679
140regulation of fever generation (GO:0031620)2.37181863
141negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.37147146
142pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.37010476
143mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.36680887
144antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.35685838
145protein localization to mitochondrion (GO:0070585)2.35568103
146positive regulation of Rho protein signal transduction (GO:0035025)2.34085787
147glutathione derivative biosynthetic process (GO:1901687)2.34081994
148glutathione derivative metabolic process (GO:1901685)2.34081994
149mitotic nuclear envelope reassembly (GO:0007084)2.33932407
150nuclear envelope reassembly (GO:0031468)2.33932407
151intracellular pH reduction (GO:0051452)2.33283975
152regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.33272781
153L-methionine salvage (GO:0071267)2.33262204
154L-methionine biosynthetic process (GO:0071265)2.33262204
155amino acid salvage (GO:0043102)2.33262204
156L-phenylalanine metabolic process (GO:0006558)2.33134670
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.33134670
158regulation of collateral sprouting (GO:0048670)2.32888058
159membrane lipid catabolic process (GO:0046466)2.32451612
160mitotic metaphase plate congression (GO:0007080)2.32451479
161negative regulation of JAK-STAT cascade (GO:0046426)2.32182024
162keratan sulfate catabolic process (GO:0042340)2.31550418
163peroxisome fission (GO:0016559)2.31459410
164sequestering of actin monomers (GO:0042989)2.31343366
165pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.31132597
166dopamine biosynthetic process (GO:0042416)2.30613259
167platelet degranulation (GO:0002576)2.29132180
168positive regulation of cellular amine metabolic process (GO:0033240)2.28593253
169limb bud formation (GO:0060174)2.26229946
170nucleoside diphosphate catabolic process (GO:0009134)2.26092507
171positive regulation of amino acid transport (GO:0051957)2.25872152
172GTP biosynthetic process (GO:0006183)2.25021207
173regulation of vacuole organization (GO:0044088)2.25020358
174long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.24503749
175long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.24493181
176regulation of metalloenzyme activity (GO:0048552)2.24300525
177negative regulation of synaptic transmission, GABAergic (GO:0032229)2.23996710
178virion attachment to host cell (GO:0019062)2.21919236
179adhesion of symbiont to host cell (GO:0044650)2.21919236
180cofactor catabolic process (GO:0051187)2.21365147
181neutrophil activation involved in immune response (GO:0002283)2.21115365
182response to misfolded protein (GO:0051788)2.20926182
183negative regulation of protein localization to cell surface (GO:2000009)2.20129945
184neural nucleus development (GO:0048857)2.19692449
185positive regulation of protein homodimerization activity (GO:0090073)2.17924421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.43798466
2CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98167041
3EST1_17652178_ChIP-ChIP_JURKAT_Human2.91784091
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68139324
5ELK1_19687146_ChIP-ChIP_HELA_Human2.65254955
6CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44618461
7TAF15_26573619_Chip-Seq_HEK293_Human2.30836802
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27855345
9E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24333220
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.23545599
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18157592
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14570642
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14295354
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14272913
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12132493
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10114848
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09354797
18DCP1A_22483619_ChIP-Seq_HELA_Human2.07134311
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01716831
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01596512
21EZH2_22144423_ChIP-Seq_EOC_Human2.00531849
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96604420
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94196990
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93593373
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.90256674
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89230398
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88784562
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87659363
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.87564762
30VDR_22108803_ChIP-Seq_LS180_Human1.85324715
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82693386
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82103751
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80780073
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74932003
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74794061
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73967621
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72543335
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70597846
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.67863684
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65501586
41* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65367142
42* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.64187239
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62733941
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61835882
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61234485
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60489851
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60437945
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.60045021
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59949769
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.58745151
51ER_23166858_ChIP-Seq_MCF-7_Human1.58423443
52VDR_23849224_ChIP-Seq_CD4+_Human1.57705325
53TFEB_21752829_ChIP-Seq_HELA_Human1.56427532
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56325475
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.56323405
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55328131
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53189416
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49079486
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47218182
60P300_19829295_ChIP-Seq_ESCs_Human1.46322802
61NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.45619059
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45415249
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45415249
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45005374
65GABP_19822575_ChIP-Seq_HepG2_Human1.43726919
66* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43182804
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.40945967
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39687337
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39002485
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37859032
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34473981
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34074821
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33498342
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.33296896
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.32899656
76RNF2_27304074_Chip-Seq_NSC_Mouse1.29193163
77HTT_18923047_ChIP-ChIP_STHdh_Human1.27662802
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26657598
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24598420
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23660686
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23533841
82EOMES_21245162_ChIP-Seq_HESCs_Human1.23464559
83CLOCK_20551151_ChIP-Seq_293T_Human1.23017932
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22817709
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22471806
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22440124
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22393260
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22069246
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.21826337
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21591876
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19534993
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19033911
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19033911
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.18788711
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18134755
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18003859
97FOXP3_21729870_ChIP-Seq_TREG_Human1.17203343
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17073493
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.17021234
100EWS_26573619_Chip-Seq_HEK293_Human1.16675230
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.14904431
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13650913
103NANOG_19829295_ChIP-Seq_ESCs_Human1.13554146
104SOX2_19829295_ChIP-Seq_ESCs_Human1.13554146
105BRD4_25478319_ChIP-Seq_HGPS_Human1.13510033
106CJUN_26792858_Chip-Seq_BT549_Human1.12981935
107REST_21632747_ChIP-Seq_MESCs_Mouse1.12697719
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12674325
109SOX2_20726797_ChIP-Seq_SW620_Human1.12279251
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11498591
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10681567
112* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10361318
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.08834230
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.07997121
115JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06518542
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06282548
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.05419128
118BP1_19119308_ChIP-ChIP_Hs578T_Human1.05020001
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04746796
120MYC_18940864_ChIP-ChIP_HL60_Human1.04663335
121IGF1R_20145208_ChIP-Seq_DFB_Human1.04217152
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03512202
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02085337
124REST_18959480_ChIP-ChIP_MESCs_Mouse1.01954702
125* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00606893
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.00401594
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00309262
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99469504
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99255216
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99238700
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99036401
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.98899623
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98825315
134TTF2_22483619_ChIP-Seq_HELA_Human0.98587347
135AR_21909140_ChIP-Seq_LNCAP_Human0.98123894
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97982692
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97683739
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97009608
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.96977677
140SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96785018
141ELF5_23300383_ChIP-Seq_T47D_Human0.95745367
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94053246
143SMAD4_21799915_ChIP-Seq_A2780_Human0.93668329
144SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92899137
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.92056338
146P53_22387025_ChIP-Seq_ESCs_Mouse0.91935508
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91847951
148FUS_26573619_Chip-Seq_HEK293_Human0.91684122
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91421356
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91108178
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90683646
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90157423
153ZNF263_19887448_ChIP-Seq_K562_Human0.90052146
154* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88716293
155SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88671638
156IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88549896
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.88509475
158TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88486883
159ZNF274_21170338_ChIP-Seq_K562_Hela0.88481081
160WT1_19549856_ChIP-ChIP_CCG9911_Human0.86082479
161CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85589307
162CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85564607
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85449245
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.84582316
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84207185
166EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84118275
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83983753
168* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83548298
169P300_18555785_Chip-Seq_ESCs_Mouse0.83133240
170EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83094721
171JUN_21703547_ChIP-Seq_K562_Human0.83073554
172KDM2B_26808549_Chip-Seq_REH_Human0.82758674
173ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82542908
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82017973
175NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81868992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.75307664
2MP0003880_abnormal_central_pattern3.23471811
3MP0004272_abnormal_basement_membrane3.20489851
4MP0003941_abnormal_skin_development3.14471224
5MP0005464_abnormal_platelet_physiology2.97550677
6MP0001529_abnormal_vocalization2.75994979
7MP0009840_abnormal_foam_cell2.66026968
8MP0000920_abnormal_myelination2.65377058
9MP0002254_reproductive_system_inflammat2.61968071
10MP0001905_abnormal_dopamine_level2.61621461
11MP0000343_altered_response_to2.61589295
12MP0005171_absent_coat_pigmentation2.38706774
13MP0004043_abnormal_pH_regulation2.37096995
14MP0010386_abnormal_urinary_bladder2.18703322
15MP0003195_calcinosis2.10719347
16MP0009379_abnormal_foot_pigmentation2.04900154
17MP0006276_abnormal_autonomic_nervous2.03849797
18MP0005257_abnormal_intraocular_pressure1.96397697
19MP0005058_abnormal_lysosome_morphology1.93660798
20MP0003718_maternal_effect1.92120972
21MP0002876_abnormal_thyroid_physiology1.91956896
22MP0002272_abnormal_nervous_system1.90480815
23MP0002736_abnormal_nociception_after1.88221472
24MP0003566_abnormal_cell_adhesion1.85931225
25MP0005646_abnormal_pituitary_gland1.84017725
26MP0002064_seizures1.80207220
27MP0004270_analgesia1.78780580
28MP0005165_increased_susceptibility_to1.76067575
29MP0003806_abnormal_nucleotide_metabolis1.76055829
30MP0001188_hyperpigmentation1.75441929
31MP0003690_abnormal_glial_cell1.70569247
32MP0004142_abnormal_muscle_tone1.69503411
33MP0000358_abnormal_cell_content/1.68685788
34MP0003950_abnormal_plasma_membrane1.64911282
35MP0009745_abnormal_behavioral_response1.63199538
36MP0004147_increased_porphyrin_level1.59780667
37MP0003279_aneurysm1.58152795
38MP0010368_abnormal_lymphatic_system1.57421209
39MP0004742_abnormal_vestibular_system1.56991799
40MP0005451_abnormal_body_composition1.56391646
41MP0005084_abnormal_gallbladder_morpholo1.55846023
42MP0001986_abnormal_taste_sensitivity1.55567687
43MP0002735_abnormal_chemical_nociception1.53589032
44MP0002734_abnormal_mechanical_nocicepti1.51036242
45MP0002148_abnormal_hypersensitivity_rea1.50848208
46MP0009764_decreased_sensitivity_to1.48532058
47MP0001968_abnormal_touch/_nociception1.46474838
48MP0003183_abnormal_peptide_metabolism1.46207966
49MP0005645_abnormal_hypothalamus_physiol1.46166072
50MP0003186_abnormal_redox_activity1.45159387
51MP0003448_altered_tumor_morphology1.45080399
52MP0006035_abnormal_mitochondrial_morpho1.43569502
53MP0002139_abnormal_hepatobiliary_system1.43226726
54MP0008875_abnormal_xenobiotic_pharmacok1.43197290
55MP0005275_abnormal_skin_tensile1.42326652
56MP0001243_abnormal_dermal_layer1.41903010
57MP0002877_abnormal_melanocyte_morpholog1.39607360
58MP0000778_abnormal_nervous_system1.39214403
59MP0005167_abnormal_blood-brain_barrier1.37557468
60MP0009046_muscle_twitch1.36693434
61MP0000013_abnormal_adipose_tissue1.35579300
62MP0003724_increased_susceptibility_to1.32952825
63MP0002572_abnormal_emotion/affect_behav1.32332026
64MP0005623_abnormal_meninges_morphology1.31366870
65MP0008007_abnormal_cellular_replicative1.31046405
66MP0002638_abnormal_pupillary_reflex1.30382854
67MP0005409_darkened_coat_color1.29987740
68MP0002102_abnormal_ear_morphology1.29705228
69MP0002837_dystrophic_cardiac_calcinosis1.29567338
70MP0009384_cardiac_valve_regurgitation1.29096524
71MP0001984_abnormal_olfaction1.27881266
72MP0003634_abnormal_glial_cell1.27707179
73MP0003329_amyloid_beta_deposits1.27474590
74MP0003635_abnormal_synaptic_transmissio1.26937814
75MP0001501_abnormal_sleep_pattern1.26083573
76MP0000372_irregular_coat_pigmentation1.25863106
77MP0001486_abnormal_startle_reflex1.23868161
78MP0005408_hypopigmentation1.21277646
79MP0005023_abnormal_wound_healing1.21003606
80MP0001970_abnormal_pain_threshold1.20463626
81MP0003011_delayed_dark_adaptation1.19740282
82MP0008932_abnormal_embryonic_tissue1.18787108
83MP0000538_abnormal_urinary_bladder1.16252356
84MP0000516_abnormal_urinary_system1.15486007
85MP0005367_renal/urinary_system_phenotyp1.15486007
86MP0001502_abnormal_circadian_rhythm1.13700105
87MP0000647_abnormal_sebaceous_gland1.13528061
88MP0002067_abnormal_sensory_capabilities1.12676115
89MP0004510_myositis1.12577840
90MP0002295_abnormal_pulmonary_circulatio1.12045012
91MP0002063_abnormal_learning/memory/cond1.11728777
92MP0005360_urolithiasis1.10320843
93MP0009697_abnormal_copulation1.10252745
94MP0003136_yellow_coat_color1.09735492
95MP0005551_abnormal_eye_electrophysiolog1.09731620
96MP0003122_maternal_imprinting1.09390754
97MP0005332_abnormal_amino_acid1.09287778
98MP0005410_abnormal_fertilization1.09237139
99MP0002733_abnormal_thermal_nociception1.09166751
100MP0002229_neurodegeneration1.08929576
101MP0001879_abnormal_lymphatic_vessel1.07363328
102MP0005423_abnormal_somatic_nervous1.06908340
103MP0005503_abnormal_tendon_morphology1.05973183
104MP0003075_altered_response_to1.05950727
105MP0002090_abnormal_vision1.05764381
106MP0005379_endocrine/exocrine_gland_phen1.03953548
107MP0005164_abnormal_response_to1.03730496
108MP0005508_abnormal_skeleton_morphology1.01662453
109MP0005636_abnormal_mineral_homeostasis1.00940826
110MP0006082_CNS_inflammation1.00148401
111MP0004134_abnormal_chest_morphology0.99962468
112MP0001764_abnormal_homeostasis0.99903411
113MP0009780_abnormal_chondrocyte_physiolo0.96854850
114MP0006036_abnormal_mitochondrial_physio0.95989326
115MP0001849_ear_inflammation0.93857501
116MP0008058_abnormal_DNA_repair0.93375073
117MP0001440_abnormal_grooming_behavior0.93180519
118MP0004883_abnormal_blood_vessel0.92968451
119MP0010030_abnormal_orbit_morphology0.92456843
120MP0000230_abnormal_systemic_arterial0.91470427
121MP0001963_abnormal_hearing_physiology0.90836447
122MP0005535_abnormal_body_temperature0.90149021
123MP0009765_abnormal_xenobiotic_induced0.89467980
124MP0000681_abnormal_thyroid_gland0.89084507
125MP0003638_abnormal_response/metabolism_0.88509978
126MP0002557_abnormal_social/conspecific_i0.88313474
127MP0001664_abnormal_digestion0.87749742
128MP0008260_abnormal_autophagy0.87194204
129MP0005365_abnormal_bile_salt0.87091659
130MP0001853_heart_inflammation0.85944166
131MP0000631_abnormal_neuroendocrine_gland0.85482178
132MP0002998_abnormal_bone_remodeling0.84111404
133MP0004957_abnormal_blastocyst_morpholog0.83824082
134MP0001542_abnormal_bone_strength0.83814875
135MP0002066_abnormal_motor_capabilities/c0.82874128
136MP0001727_abnormal_embryo_implantation0.82372159
137MP0006072_abnormal_retinal_apoptosis0.81992498
138MP0000026_abnormal_inner_ear0.81725510
139MP0005193_abnormal_anterior_eye0.81626143
140MP0003795_abnormal_bone_structure0.81195350
141MP0009053_abnormal_anal_canal0.81013825
142MP0000015_abnormal_ear_pigmentation0.80495551
143MP0003693_abnormal_embryo_hatching0.80129740
144MP0008438_abnormal_cutaneous_collagen0.80036347
145MP0000604_amyloidosis0.79751762
146MP0002896_abnormal_bone_mineralization0.79573575
147MP0000858_altered_metastatic_potential0.78802855
148MP0002282_abnormal_trachea_morphology0.78199848
149MP0008004_abnormal_stomach_pH0.78040664
150MP0001299_abnormal_eye_distance/0.77468513
151MP0008873_increased_physiological_sensi0.77467994
152MP0009763_increased_sensitivity_to0.76378834
153MP0005197_abnormal_uvea_morphology0.76180189
154MP0001756_abnormal_urination0.75460603
155MP0005595_abnormal_vascular_smooth0.75238499
156MP0003191_abnormal_cellular_cholesterol0.74723426
157MP0004885_abnormal_endolymph0.74436463
158MP0010771_integument_phenotype0.73611664
159MP0000462_abnormal_digestive_system0.73549976
160MP0004924_abnormal_behavior0.73471730
161MP0005386_behavior/neurological_phenoty0.73471730
162MP0001533_abnormal_skeleton_physiology0.72576645
163MP0005501_abnormal_skin_physiology0.70713117
164MP0001191_abnormal_skin_condition0.67952567
165MP0005390_skeleton_phenotype0.66249835
166MP0002060_abnormal_skin_morphology0.63496988
167MP0010352_gastrointestinal_tract_polyps0.59912748
168MP0000537_abnormal_urethra_morphology0.57878195
169MP0002972_abnormal_cardiac_muscle0.57453143
170MP0005384_cellular_phenotype0.57115063

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.35553613
2Abnormal mitochondria in muscle tissue (HP:0008316)4.89814987
3Acute encephalopathy (HP:0006846)4.64461483
4Mitochondrial inheritance (HP:0001427)4.61888095
5Progressive macrocephaly (HP:0004481)4.33052875
6Hepatocellular necrosis (HP:0001404)4.08171132
7Petechiae (HP:0000967)3.88560360
8Abnormality of glycolipid metabolism (HP:0010969)3.77996622
9Abnormality of liposaccharide metabolism (HP:0010968)3.77996622
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.77996622
11Increased CSF lactate (HP:0002490)3.75615487
12Hepatic necrosis (HP:0002605)3.61139766
13Renal Fanconi syndrome (HP:0001994)3.50480046
143-Methylglutaconic aciduria (HP:0003535)3.50203282
15Abnormality of glycolysis (HP:0004366)3.45126038
16Increased serum pyruvate (HP:0003542)3.45126038
17Premature rupture of membranes (HP:0001788)3.41268012
18Purpura (HP:0000979)3.19247045
19Increased hepatocellular lipid droplets (HP:0006565)3.16839791
20Neuroendocrine neoplasm (HP:0100634)3.14170218
21Leukodystrophy (HP:0002415)3.13600638
22Tetraparesis (HP:0002273)3.13007478
23Cerebral edema (HP:0002181)3.08551215
24Menorrhagia (HP:0000132)3.06127413
25Increased mean platelet volume (HP:0011877)3.05445069
26Pheochromocytoma (HP:0002666)3.03759847
27Lipid accumulation in hepatocytes (HP:0006561)2.98947352
28Neurofibrillary tangles (HP:0002185)2.87228181
29Nausea (HP:0002018)2.84943273
30Hypothermia (HP:0002045)2.82995625
31Disinhibition (HP:0000734)2.81047154
32Retinal dysplasia (HP:0007973)2.80310059
33Mutism (HP:0002300)2.77475203
34Respiratory failure (HP:0002878)2.75230446
35Lactic acidosis (HP:0003128)2.74561386
36Optic disc pallor (HP:0000543)2.72765988
37Abnormality of renal resorption (HP:0011038)2.72297267
38Systemic lupus erythematosus (HP:0002725)2.70786871
39Increased intramyocellular lipid droplets (HP:0012240)2.68448330
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.63312851
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.59838389
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.59166621
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59154937
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57683795
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55449238
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.54722073
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.54327709
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54327709
49Sensory axonal neuropathy (HP:0003390)2.51525697
50Vacuolated lymphocytes (HP:0001922)2.49344347
51Loss of speech (HP:0002371)2.49305437
52Reduced antithrombin III activity (HP:0001976)2.47343331
53Exercise intolerance (HP:0003546)2.46933644
54Agnosia (HP:0010524)2.45446205
55Abnormal platelet volume (HP:0011876)2.44062953
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43665989
57Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43665989
58Abnormal protein glycosylation (HP:0012346)2.40780140
59Abnormal glycosylation (HP:0012345)2.40780140
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40780140
61Abnormal protein N-linked glycosylation (HP:0012347)2.40780140
62Nuclear cataract (HP:0100018)2.39739690
63Increased muscle lipid content (HP:0009058)2.38825871
64Medial flaring of the eyebrow (HP:0010747)2.38114939
65Sensorimotor neuropathy (HP:0007141)2.37924470
66Metaphyseal dysplasia (HP:0100255)2.35852479
67Increased serum lactate (HP:0002151)2.34871228
68Abnormality of urine glucose concentration (HP:0011016)2.33723747
69Glycosuria (HP:0003076)2.33723747
70Conjunctival telangiectasia (HP:0000524)2.30509432
71Prolonged partial thromboplastin time (HP:0003645)2.28368847
72Hypomagnesemia (HP:0002917)2.28287808
73Abnormality of methionine metabolism (HP:0010901)2.28230863
74Parakeratosis (HP:0001036)2.26975267
75Type II lissencephaly (HP:0007260)2.26904613
76Short middle phalanx of the 5th finger (HP:0004220)2.26717382
77Abnormal hair whorl (HP:0010721)2.25871124
78Methylmalonic acidemia (HP:0002912)2.25082663
79Methylmalonic aciduria (HP:0012120)2.24932193
80Cerebral hemorrhage (HP:0001342)2.23431643
81Intrahepatic cholestasis (HP:0001406)2.22012279
82Increased cerebral lipofuscin (HP:0011813)2.21384900
83Basal ganglia calcification (HP:0002135)2.21367481
84Abnormality of alanine metabolism (HP:0010916)2.18060099
85Hyperalaninemia (HP:0003348)2.18060099
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18060099
87Abnormality of magnesium homeostasis (HP:0004921)2.17696194
88Postnatal microcephaly (HP:0005484)2.13600002
89Myokymia (HP:0002411)2.12816733
90Abnormality of the basal ganglia (HP:0002134)2.10824954
91Poor suck (HP:0002033)2.09729552
92Renal tubular dysfunction (HP:0000124)2.09406787
93Degeneration of anterior horn cells (HP:0002398)2.06860683
94Abnormality of the anterior horn cell (HP:0006802)2.06860683
95Hyperventilation (HP:0002883)2.05819390
96Sparse eyelashes (HP:0000653)2.05602636
97Upper limb muscle weakness (HP:0003484)2.04826173
98Rough bone trabeculation (HP:0100670)2.04656229
99Generalized aminoaciduria (HP:0002909)2.04555348
100Spastic paraparesis (HP:0002313)2.03101774
101Nephrogenic diabetes insipidus (HP:0009806)2.02102568
102Gait imbalance (HP:0002141)2.01098693
103Vascular calcification (HP:0004934)2.00436580
104Increased neuronal autofluorescent lipopigment (HP:0002074)2.00410571
105Follicular hyperkeratosis (HP:0007502)1.99966393
106Cardiovascular calcification (HP:0011915)1.99419283
107Poor head control (HP:0002421)1.98723487
108Vaginal atresia (HP:0000148)1.97215196
109Congenital primary aphakia (HP:0007707)1.95432141
110Delusions (HP:0000746)1.94994577
111Polyphagia (HP:0002591)1.94724651
112Prolonged bleeding time (HP:0003010)1.94056600
113Exertional dyspnea (HP:0002875)1.93431738
114X-linked dominant inheritance (HP:0001423)1.89817726
115Abnormal trabecular bone morphology (HP:0100671)1.89648461
116Metabolic alkalosis (HP:0200114)1.89415832
117Patchy hypopigmentation of hair (HP:0011365)1.88853201
118Genital tract atresia (HP:0001827)1.88598462
119Beaking of vertebral bodies (HP:0004568)1.88039560
120Dry hair (HP:0011359)1.88032680
121Paralysis (HP:0003470)1.87536362
122Hypophosphatemic rickets (HP:0004912)1.86512464
123Congenital, generalized hypertrichosis (HP:0004540)1.85557570
124Lethargy (HP:0001254)1.85067866
125Abnormality of serum amino acid levels (HP:0003112)1.84215472
126Autoamputation (HP:0001218)1.83890768
127Limb dystonia (HP:0002451)1.83274005
128Prolonged neonatal jaundice (HP:0006579)1.81967238
129Hepatosplenomegaly (HP:0001433)1.81949367
130Bifid tongue (HP:0010297)1.80022564
131Irregular vertebral endplates (HP:0003301)1.78974057
132Abnormal pupillary function (HP:0007686)1.78753170
133CNS demyelination (HP:0007305)1.78719398
134Abnormal platelet function (HP:0011869)1.78492384
135Impaired platelet aggregation (HP:0003540)1.78492384
136Hyperphosphaturia (HP:0003109)1.78368179
137Vertebral compression fractures (HP:0002953)1.77244853
138Progressive neurologic deterioration (HP:0002344)1.76670916
139Congenital ichthyosiform erythroderma (HP:0007431)1.76417805
140Cerebral hypomyelination (HP:0006808)1.76190279
141Hyperglycinemia (HP:0002154)1.75755890
142Focal motor seizures (HP:0011153)1.75313691
143Delayed gross motor development (HP:0002194)1.75060568
144Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.75011972
145Fasciculations (HP:0002380)1.73759855
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.73715923
147Absent/shortened dynein arms (HP:0200106)1.73715923
148Opisthotonus (HP:0002179)1.72951472
149Poor speech (HP:0002465)1.72631606
150Type I transferrin isoform profile (HP:0003642)1.71072455
151Hypokalemic alkalosis (HP:0001949)1.70796197
152White forelock (HP:0002211)1.69822923
153Dysostosis multiplex (HP:0000943)1.69608155
154Conjugated hyperbilirubinemia (HP:0002908)1.69341506
155Thyroid-stimulating hormone excess (HP:0002925)1.68396259
156Atonic seizures (HP:0010819)1.67420049
157Vomiting (HP:0002013)1.66865484
158Lissencephaly (HP:0001339)1.65321993
159Abnormal ciliary motility (HP:0012262)1.64609422
160Increased circulating renin level (HP:0000848)1.64031154
161Thickened helices (HP:0000391)1.63579954
162Abnormality of dicarboxylic acid metabolism (HP:0010995)1.61709360
163Dicarboxylic aciduria (HP:0003215)1.61709360
164Respiratory difficulties (HP:0002880)1.59091958
165Cerebral inclusion bodies (HP:0100314)1.57069855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.61186331
2OXSR13.29455540
3NME23.14880873
4STK393.14503314
5STK162.93030873
6TRIM282.69200428
7BCR2.28718634
8MAP3K122.26869798
9CDK192.26667095
10BMPR1B1.99269290
11PRPF4B1.93018882
12BUB11.92375718
13WNK41.86551241
14MST41.80954458
15TNIK1.80469358
16ARAF1.78808076
17GRK71.70710669
18LIMK11.70363276
19TSSK61.63924002
20ADRBK21.63755469
21WNK31.63633231
22PBK1.62530052
23MYLK1.59826957
24SRPK11.59648543
25EIF2AK11.55696812
26MAPK131.53051238
27DYRK21.46842987
28MAPK151.45987750
29NEK11.45702081
30CSNK1G31.45080341
31BCKDK1.42590376
32MAPKAPK51.42110164
33SCYL21.40523592
34NME11.37436394
35MAP4K21.37274306
36ACVR1B1.36951691
37BMX1.35464336
38TAOK21.33615778
39EIF2AK31.32802549
40PLK31.32660469
41MAP2K71.27254842
42SIK31.26479765
43MARK11.20075047
44FER1.19830459
45PAK41.19437176
46TGFBR21.19341344
47PKN11.18352375
48DDR21.18054064
49CAMK2B1.17740337
50BMPR21.16881308
51VRK21.16291930
52NEK61.15177154
53VRK11.14455012
54BRAF1.13834782
55MET1.13739954
56TAOK31.10771613
57SGK4941.09729743
58SGK2231.09729743
59PNCK1.08829561
60CSNK1G11.06365114
61TIE11.02659911
62IRAK31.02263132
63CSNK1A1L1.02079460
64PIK3CG0.98571328
65NUAK10.96108745
66GRK50.95371323
67CSNK1G20.93738939
68EPHB20.93413626
69PRKCE0.93365303
70AKT30.91192504
71MKNK10.91138333
72MAP3K50.90445812
73EPHA40.89831421
74CAMK2G0.89492006
75IRAK40.88952498
76MUSK0.88792341
77UHMK10.87187098
78PTK2B0.85693087
79CAMK2D0.85128924
80INSRR0.83028536
81YES10.82876014
82RPS6KA40.82127023
83CAMK2A0.81100611
84TTK0.80988608
85PIM20.79689093
86STK30.77510947
87PAK10.75131543
88FGR0.74050244
89MKNK20.73224237
90IRAK10.72429522
91ROCK20.72273791
92MATK0.72241182
93PRKCG0.71526450
94EPHB10.70767617
95PLK10.68833009
96LATS20.68243889
97PLK20.64667063
98FGFR20.64259347
99DAPK10.63957790
100CDK50.62899583
101GRK10.60983902
102ADRBK10.60496516
103CCNB10.60347550
104TESK10.59681406
105CDC70.59355312
106TRPM70.58662394
107MAP2K20.58119230
108PTK20.57467662
109DYRK30.57166611
110ABL20.56984528
111MAP3K30.56343561
112ERBB40.56205216
113PAK20.55222685
114CDK80.54774103
115TGFBR10.54662249
116DAPK30.54386776
117PRKG20.54214414
118FLT30.54036996
119CSF1R0.53647064
120CDK140.52049414
121ZAK0.51460240
122CDK180.51114848
123AURKA0.51001554
124DAPK20.50085366
125IRAK20.48412330
126OBSCN0.47881931
127FES0.46815904
128KDR0.46089782
129MINK10.45105200
130ERBB30.45055566
131CSNK2A10.44834162
132CDK150.43556122
133TLK10.43411114
134PAK30.43316831
135MOS0.42889120
136NTRK10.42835074
137CSNK1A10.42542476
138GSK3A0.42479361
139FGFR10.42328939
140STK40.42324289
141PRKACA0.41991539
142MAP3K140.41989200
143KIT0.41829983
144WEE10.41496198
145PRKCD0.40718555
146CDK11A0.40686367
147MAP3K110.39625397
148PDK20.39005003
149NTRK30.37510302
150EPHA30.37492497
151TESK20.37052251
152PRKG10.35530224
153ILK0.35264269

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.67171681
2Protein export_Homo sapiens_hsa030603.74932614
3Parkinsons disease_Homo sapiens_hsa050123.52391737
4Sulfur metabolism_Homo sapiens_hsa009202.90814655
5Fatty acid elongation_Homo sapiens_hsa000622.88413399
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77816232
7Alzheimers disease_Homo sapiens_hsa050102.76442166
8Collecting duct acid secretion_Homo sapiens_hsa049662.63031140
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.35339444
10Huntingtons disease_Homo sapiens_hsa050162.26526264
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26523165
12Steroid biosynthesis_Homo sapiens_hsa001002.25163448
13Vibrio cholerae infection_Homo sapiens_hsa051102.06099293
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93768575
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90060977
16Proteasome_Homo sapiens_hsa030501.82792634
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68425097
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65737716
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61598155
20Histidine metabolism_Homo sapiens_hsa003401.59976630
21Rheumatoid arthritis_Homo sapiens_hsa053231.59393839
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53301291
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.41427822
24Synaptic vesicle cycle_Homo sapiens_hsa047211.38998355
25Butanoate metabolism_Homo sapiens_hsa006501.38914303
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38592966
27Ether lipid metabolism_Homo sapiens_hsa005651.33060097
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32611428
29Mismatch repair_Homo sapiens_hsa034301.30783712
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29316018
31Sphingolipid metabolism_Homo sapiens_hsa006001.29025535
32Cardiac muscle contraction_Homo sapiens_hsa042601.26242358
33Peroxisome_Homo sapiens_hsa041461.25861688
34Pyruvate metabolism_Homo sapiens_hsa006201.25092176
35Phagosome_Homo sapiens_hsa041451.21410159
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.18190893
37Propanoate metabolism_Homo sapiens_hsa006401.17856398
38Shigellosis_Homo sapiens_hsa051311.16841136
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10796861
40Lysosome_Homo sapiens_hsa041421.10316533
41Arachidonic acid metabolism_Homo sapiens_hsa005901.09541664
42Basal transcription factors_Homo sapiens_hsa030221.09062054
43ECM-receptor interaction_Homo sapiens_hsa045121.08753467
44Chemical carcinogenesis_Homo sapiens_hsa052041.08610144
45Glutathione metabolism_Homo sapiens_hsa004801.07660102
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.06934622
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05609748
48Pyrimidine metabolism_Homo sapiens_hsa002401.03299842
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00762557
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98372679
51Nicotine addiction_Homo sapiens_hsa050330.93661173
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92951694
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91290182
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88903573
55Metabolic pathways_Homo sapiens_hsa011000.88440371
56Folate biosynthesis_Homo sapiens_hsa007900.87404873
57Salmonella infection_Homo sapiens_hsa051320.85253788
58GABAergic synapse_Homo sapiens_hsa047270.85191865
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84272834
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83377283
61Other glycan degradation_Homo sapiens_hsa005110.82430318
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80775450
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80170330
64Linoleic acid metabolism_Homo sapiens_hsa005910.80021676
65Serotonergic synapse_Homo sapiens_hsa047260.80014266
66RNA polymerase_Homo sapiens_hsa030200.79951890
67Selenocompound metabolism_Homo sapiens_hsa004500.79355278
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77111536
69Regulation of autophagy_Homo sapiens_hsa041400.76968043
70Nucleotide excision repair_Homo sapiens_hsa034200.76843977
71Arginine and proline metabolism_Homo sapiens_hsa003300.76343745
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75782549
73Tyrosine metabolism_Homo sapiens_hsa003500.73484863
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71974231
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70754768
76Fatty acid metabolism_Homo sapiens_hsa012120.70205168
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67097866
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65372624
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64649728
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63929759
81Legionellosis_Homo sapiens_hsa051340.62442159
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.60649422
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59961685
84Morphine addiction_Homo sapiens_hsa050320.58826887
85beta-Alanine metabolism_Homo sapiens_hsa004100.58249048
86Galactose metabolism_Homo sapiens_hsa000520.58223328
87Tryptophan metabolism_Homo sapiens_hsa003800.56316277
88Fatty acid degradation_Homo sapiens_hsa000710.56176637
89Phototransduction_Homo sapiens_hsa047440.54612462
90Sulfur relay system_Homo sapiens_hsa041220.53371840
91Phenylalanine metabolism_Homo sapiens_hsa003600.52574340
92Cocaine addiction_Homo sapiens_hsa050300.50715218
93Base excision repair_Homo sapiens_hsa034100.50185192
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49370696
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48641402
96Retinol metabolism_Homo sapiens_hsa008300.48264611
97RNA transport_Homo sapiens_hsa030130.48234346
98Autoimmune thyroid disease_Homo sapiens_hsa053200.47418739
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.47238203
100Caffeine metabolism_Homo sapiens_hsa002320.46247038
101p53 signaling pathway_Homo sapiens_hsa041150.45485676
102Taste transduction_Homo sapiens_hsa047420.44895613
103Biosynthesis of amino acids_Homo sapiens_hsa012300.44794818
104Axon guidance_Homo sapiens_hsa043600.43617247
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43380545
106TGF-beta signaling pathway_Homo sapiens_hsa043500.43340907
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41961180
108Circadian entrainment_Homo sapiens_hsa047130.41038729
109Vitamin B6 metabolism_Homo sapiens_hsa007500.40833674
110Glutamatergic synapse_Homo sapiens_hsa047240.40415328
111RNA degradation_Homo sapiens_hsa030180.40331241
112Mineral absorption_Homo sapiens_hsa049780.39664809
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39197643
114Endocytosis_Homo sapiens_hsa041440.38984631
115Complement and coagulation cascades_Homo sapiens_hsa046100.38815976
116Malaria_Homo sapiens_hsa051440.36460601
117DNA replication_Homo sapiens_hsa030300.36041724
118N-Glycan biosynthesis_Homo sapiens_hsa005100.35944466
119Spliceosome_Homo sapiens_hsa030400.32516884
120Renin-angiotensin system_Homo sapiens_hsa046140.32178359
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30669396
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.28727684
123Purine metabolism_Homo sapiens_hsa002300.28512195
124Insulin secretion_Homo sapiens_hsa049110.28209807
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28108535
126Ribosome_Homo sapiens_hsa030100.26868615
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25355155
128Carbon metabolism_Homo sapiens_hsa012000.24934877
129Vitamin digestion and absorption_Homo sapiens_hsa049770.24000405
130Fructose and mannose metabolism_Homo sapiens_hsa000510.22931655
131Asthma_Homo sapiens_hsa053100.22806796
132Pertussis_Homo sapiens_hsa051330.21639977
133PPAR signaling pathway_Homo sapiens_hsa033200.20587598
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20205266

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