TM4SF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.90979626
2negative regulation of complement activation (GO:0045916)5.40921650
3negative regulation of protein activation cascade (GO:2000258)5.24970048
4vascular endothelial growth factor signaling pathway (GO:0038084)5.03102999
5glomerular visceral epithelial cell development (GO:0072015)4.98932708
6cell adhesion mediated by integrin (GO:0033627)4.98144787
7protein hydroxylation (GO:0018126)4.86957474
8retina vasculature morphogenesis in camera-type eye (GO:0061299)4.84891404
9glomerular epithelial cell development (GO:0072310)4.83717181
10peptidyl-proline hydroxylation (GO:0019511)4.83469869
11glomerular basement membrane development (GO:0032836)4.76083739
12lymphangiogenesis (GO:0001946)4.69426801
13chondrocyte proliferation (GO:0035988)4.58740816
14endothelium development (GO:0003158)4.45713011
15hepatocyte differentiation (GO:0070365)4.33999975
16Golgi transport vesicle coating (GO:0048200)4.25734262
17COPI coating of Golgi vesicle (GO:0048205)4.25734262
18renal filtration (GO:0097205)4.14864090
19endothelial cell morphogenesis (GO:0001886)4.11751979
20cell migration involved in sprouting angiogenesis (GO:0002042)4.10438198
21wound healing, spreading of epidermal cells (GO:0035313)4.08717994
22positive regulation of endothelial cell apoptotic process (GO:2000353)4.07742207
23mesodermal cell differentiation (GO:0048333)3.89806553
24intestinal cholesterol absorption (GO:0030299)3.89478098
25cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.88572756
26desmosome organization (GO:0002934)3.87313864
27glomerular filtration (GO:0003094)3.84261508
28vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.81247934
29negative regulation of humoral immune response (GO:0002921)3.80337543
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73862190
31regulation of complement activation (GO:0030449)3.69539256
32neuron projection extension involved in neuron projection guidance (GO:1902284)3.65666512
33axon extension involved in axon guidance (GO:0048846)3.65666512
34nucleotide-sugar biosynthetic process (GO:0009226)3.62488504
35collagen fibril organization (GO:0030199)3.61786032
36regulation of metalloenzyme activity (GO:0048552)3.61151002
37regulation of protein activation cascade (GO:2000257)3.56406369
38blood vessel endothelial cell migration (GO:0043534)3.51243951
39protein retention in ER lumen (GO:0006621)3.49113453
40regulation of transforming growth factor beta1 production (GO:0032908)3.45455384
41ER overload response (GO:0006983)3.44211064
42L-phenylalanine metabolic process (GO:0006558)3.43925793
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.43925793
44cilium movement (GO:0003341)3.43891824
45protein localization to cell surface (GO:0034394)3.39914297
46lung vasculature development (GO:0060426)3.30331331
47negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.30318491
48wound healing, spreading of cells (GO:0044319)3.30018308
49Notch signaling involved in heart development (GO:0061314)3.27558222
50positive regulation of p38MAPK cascade (GO:1900745)3.27347410
51positive regulation of odontogenesis (GO:0042482)3.27058110
52smooth muscle tissue development (GO:0048745)3.25296061
53fibrinolysis (GO:0042730)3.24517948
54blood vessel maturation (GO:0001955)3.21123106
55regulation of endothelial cell differentiation (GO:0045601)3.17335411
56regulation of integrin-mediated signaling pathway (GO:2001044)3.14785986
57substrate-dependent cell migration (GO:0006929)3.14758880
58surfactant homeostasis (GO:0043129)3.12557985
59hemidesmosome assembly (GO:0031581)3.12433768
60COPII vesicle coating (GO:0048208)3.12120287
61basement membrane organization (GO:0071711)3.10813517
62skin morphogenesis (GO:0043589)3.09518526
63sequestering of extracellular ligand from receptor (GO:0035581)3.08430981
64blood vessel remodeling (GO:0001974)3.06995845
65hippo signaling (GO:0035329)3.06079801
66bundle of His cell to Purkinje myocyte communication (GO:0086069)3.05970636
67protein heterotrimerization (GO:0070208)3.05681415
68membrane budding (GO:0006900)3.04480871
69negative regulation of fibrinolysis (GO:0051918)3.04470077
70endodermal cell differentiation (GO:0035987)2.99830525
714-hydroxyproline metabolic process (GO:0019471)2.98708712
72sprouting angiogenesis (GO:0002040)2.98304905
73retinal metabolic process (GO:0042574)2.97032903
74iron ion import (GO:0097286)2.94578212
75low-density lipoprotein particle clearance (GO:0034383)2.93673408
76dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92590606
77regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.91784292
78regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91505701
79neural crest cell development (GO:0014032)2.90174707
80regulation of cholesterol homeostasis (GO:2000188)2.89405838
81protein carboxylation (GO:0018214)2.86948990
82peptidyl-glutamic acid carboxylation (GO:0017187)2.86948990
83coronary vasculature morphogenesis (GO:0060977)2.86384706
84mesenchymal-epithelial cell signaling (GO:0060638)2.85451137
85regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85226658
86plasma membrane repair (GO:0001778)2.84999913
87kidney mesenchyme development (GO:0072074)2.84871282
88endothelial cell differentiation (GO:0045446)2.84657072
89protein maturation by protein folding (GO:0022417)2.84616384
90metanephric mesenchyme development (GO:0072075)2.84531696
91glomerulus development (GO:0032835)2.83430403
92regulation of vasculogenesis (GO:2001212)2.82893718
93cardiac epithelial to mesenchymal transition (GO:0060317)2.82520642
94axoneme assembly (GO:0035082)2.81781320
95negative regulation of coagulation (GO:0050819)2.81531045
96axonemal dynein complex assembly (GO:0070286)2.80461866
97regulation of transmission of nerve impulse (GO:0051969)2.79688791
98regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.78335783
99epithelial cell-cell adhesion (GO:0090136)2.77645310
100heart trabecula formation (GO:0060347)2.77443543
101positive regulation of transforming growth factor beta production (GO:0071636)2.77127310
102regulation of extracellular matrix organization (GO:1903053)2.76916309
103substrate adhesion-dependent cell spreading (GO:0034446)2.76313157
104UDP-N-acetylglucosamine metabolic process (GO:0006047)2.76115309
105atrioventricular valve morphogenesis (GO:0003181)2.75105801
106branching involved in salivary gland morphogenesis (GO:0060445)2.74049645
107daunorubicin metabolic process (GO:0044597)2.73963447
108polyketide metabolic process (GO:0030638)2.73963447
109doxorubicin metabolic process (GO:0044598)2.73963447
110activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.73346303
111positive regulation of astrocyte differentiation (GO:0048711)2.73337920
112apoptotic cell clearance (GO:0043277)2.72756508
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71204489
114endocardial cushion morphogenesis (GO:0003203)2.71202748
115ribosome assembly (GO:0042255)2.70313606
116mesenchymal cell development (GO:0014031)2.69021252
117patterning of blood vessels (GO:0001569)2.68861446
118vasculogenesis (GO:0001570)2.68120861
119positive regulation of endothelial cell migration (GO:0010595)2.68073387
120bone remodeling (GO:0046849)2.67565007
121response to fluid shear stress (GO:0034405)2.67148776
122endothelial cell chemotaxis (GO:0035767)2.66897075
123venous blood vessel morphogenesis (GO:0048845)2.66436262
124positive regulation of epithelial cell migration (GO:0010634)2.66147201
125regulation of plasminogen activation (GO:0010755)2.66060047
126ganglion development (GO:0061548)2.66032053
127positive regulation of epithelial to mesenchymal transition (GO:0010718)2.65534225
128regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65395759
129artery development (GO:0060840)2.63498687
130membrane raft organization (GO:0031579)2.63340594
131collagen metabolic process (GO:0032963)2.62311021
132adhesion of symbiont to host (GO:0044406)2.61515878
133regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.59224678
134endoplasmic reticulum unfolded protein response (GO:0030968)2.58903946
135morphogenesis of an endothelium (GO:0003159)2.58079353
136endothelial tube morphogenesis (GO:0061154)2.58079353
137positive regulation of nuclease activity (GO:0032075)2.57500451
138inositol phosphate-mediated signaling (GO:0048016)2.57297178
139cell-substrate junction assembly (GO:0007044)2.56703295
140regulation of tight junction assembly (GO:2000810)2.56652865
141positive regulation of extracellular matrix organization (GO:1903055)2.55836032
142regulation of type B pancreatic cell apoptotic process (GO:2000674)2.55804658
143stress fiber assembly (GO:0043149)2.55756112
144germ cell migration (GO:0008354)2.55511730
145endocrine hormone secretion (GO:0060986)2.55265183
146endothelial cell migration (GO:0043542)2.55180641
147blood vessel morphogenesis (GO:0048514)2.54915620
148positive regulation of cell junction assembly (GO:1901890)2.54727668
149positive regulation of focal adhesion assembly (GO:0051894)2.54727668
150muscle cell migration (GO:0014812)2.54075928
151positive regulation of adherens junction organization (GO:1903393)2.53995835
152heart valve morphogenesis (GO:0003179)2.53909445
153positive regulation of osteoblast proliferation (GO:0033690)2.53406181
154cell migration involved in heart development (GO:0060973)2.53405511
155multicellular organismal macromolecule metabolic process (GO:0044259)2.53141180
156positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.53025401
157ER-nucleus signaling pathway (GO:0006984)2.52889115
158positive regulation of blood vessel endothelial cell migration (GO:0043536)2.52606470
159hyaluronan catabolic process (GO:0030214)2.52392781
160erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50946663
161L-phenylalanine catabolic process (GO:0006559)2.50946663
162regulation of transforming growth factor beta production (GO:0071634)2.50450796
163notochord development (GO:0030903)2.49061851
164aminoglycoside antibiotic metabolic process (GO:0030647)2.47733881
165angiogenesis involved in wound healing (GO:0060055)2.44953966
166negative regulation of dendrite morphogenesis (GO:0050774)2.44894059
167regulation of anoikis (GO:2000209)2.44443930
168negative regulation of hemostasis (GO:1900047)2.44191113
169negative regulation of blood coagulation (GO:0030195)2.44191113
170negative regulation of wound healing (GO:0061045)2.42504175
171tonic smooth muscle contraction (GO:0014820)2.41264736
172negative regulation of chondrocyte differentiation (GO:0032331)2.41264245
173nephron tubule formation (GO:0072079)2.41029368
174cellular response to unfolded protein (GO:0034620)2.40558326
175regulation of fibrinolysis (GO:0051917)2.39916120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRIM28_21343339_ChIP-Seq_HEK293_Human5.52726228
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.04636501
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.88226056
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.71599754
5ZNF263_19887448_ChIP-Seq_K562_Human3.48459719
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25310483
7CLOCK_20551151_ChIP-Seq_293T_Human3.10249323
8* CJUN_26792858_Chip-Seq_BT549_Human2.69573603
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59566123
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.42647805
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.39532792
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.37833539
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.33477693
14* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.28178345
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.15723699
16* GATA2_21666600_ChIP-Seq_HMVEC_Human2.15302716
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.08138006
18AR_21909140_ChIP-Seq_LNCAP_Human2.05619545
19FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.05029932
20NRF2_20460467_ChIP-Seq_MEFs_Mouse2.04301974
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.04301974
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03752813
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94522521
24ATF3_27146783_Chip-Seq_COLON_Human1.92562692
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.92382412
26* ESR1_21235772_ChIP-Seq_MCF-7_Human1.92364718
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90793497
28SOX2_20726797_ChIP-Seq_SW620_Human1.88787665
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88482473
30* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87917500
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86362297
32* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86362297
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.85078407
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84967584
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.83363167
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81062639
37TP53_18474530_ChIP-ChIP_U2OS_Human1.80216023
38* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.77051578
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76739600
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75309687
41GATA6_25053715_ChIP-Seq_YYC3_Human1.74710730
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.74581982
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73753060
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.68614071
45* SMAD_19615063_ChIP-ChIP_OVARY_Human1.65159695
46* BRD4_25478319_ChIP-Seq_HGPS_Human1.64057044
47EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.60564404
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59724219
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58677812
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57409091
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57166651
52* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54560523
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53616658
54* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52715928
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48911693
56RACK7_27058665_Chip-Seq_MCF-7_Human1.48862749
57TP53_16413492_ChIP-PET_HCT116_Human1.47206389
58* FOXO3_23340844_ChIP-Seq_DLD1_Human1.46087072
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45330070
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45268696
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44070493
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43265252
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41558533
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39970877
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.39335160
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38856014
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.37138110
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33741990
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33174974
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31715718
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.30809763
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29317694
73* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27969724
74* TBX20_22328084_ChIP-Seq_HEART_Mouse1.25621824
75* TBX20_22080862_ChIP-Seq_HEART_Mouse1.25621824
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.24938034
77AHR_22903824_ChIP-Seq_MCF-7_Human1.24887258
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.24241848
79SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23954689
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23424501
81BCAT_22108803_ChIP-Seq_LS180_Human1.20121414
82* FOXA2_19822575_ChIP-Seq_HepG2_Human1.19556624
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19546775
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18832208
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18135917
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.17405835
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16706148
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.16453223
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16434634
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16204280
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.15741928
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.15078355
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.13903074
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13517448
95EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13235895
96RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13235895
97AR_21572438_ChIP-Seq_LNCaP_Human1.11718948
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11197238
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08399468
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08220286
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07910595
102SOX17_20123909_ChIP-Seq_XEN_Mouse1.07782299
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07060703
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06000646
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.05873001
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05483604
107RXR_22108803_ChIP-Seq_LS180_Human1.05130762
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04636665
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03675925
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03353547
111TP63_23658742_ChIP-Seq_EP156T_Human1.03137682
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02155106
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01344906
114* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00784133
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99367477
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99136636
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97227290
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95227686
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94510470
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94493854
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94107883
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.94041996
123KLF5_25053715_ChIP-Seq_YYC3_Human0.93814948
124TP53_22127205_ChIP-Seq_IMR90_Human0.93545768
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93402683
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92726911
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92280853
128* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92009816
129MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91370317
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90252482
131SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89730885
132SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88283771
133* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85480293
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.85175190
135JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84802456
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80094980
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.79737953
138* GATA4_25053715_ChIP-Seq_YYC3_Human0.78512739
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77955102
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.77834206
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77599412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.93546722
2MP0010368_abnormal_lymphatic_system4.43805868
3MP0004272_abnormal_basement_membrane4.25363987
4MP0005623_abnormal_meninges_morphology4.05900411
5MP0001879_abnormal_lymphatic_vessel4.01640975
6MP0005275_abnormal_skin_tensile3.70236076
7MP0003279_aneurysm3.36079919
8MP0003705_abnormal_hypodermis_morpholog3.10578027
9MP0005503_abnormal_tendon_morphology3.09914848
10MP0001958_emphysema2.74667217
11MP0009384_cardiac_valve_regurgitation2.65226975
12MP0006054_spinal_hemorrhage2.34578008
13MP0003724_increased_susceptibility_to2.19285068
14MP0003566_abnormal_cell_adhesion2.17047852
15MP0003091_abnormal_cell_migration1.98866687
16MP0000767_abnormal_smooth_muscle1.93798626
17MP0005083_abnormal_biliary_tract1.90889857
18MP0000003_abnormal_adipose_tissue1.90779398
19MP0002295_abnormal_pulmonary_circulatio1.88836547
20MP0005023_abnormal_wound_healing1.83519620
21MP0003191_abnormal_cellular_cholesterol1.83296537
22MP0005167_abnormal_blood-brain_barrier1.83050649
23MP0003950_abnormal_plasma_membrane1.81142942
24MP0009840_abnormal_foam_cell1.77506650
25MP0008004_abnormal_stomach_pH1.71792042
26MP0004084_abnormal_cardiac_muscle1.70039301
27MP0002282_abnormal_trachea_morphology1.69649693
28MP0003195_calcinosis1.66907939
29MP0009780_abnormal_chondrocyte_physiolo1.65225321
30MP0004233_abnormal_muscle_weight1.62006280
31MP0005670_abnormal_white_adipose1.57017541
32MP0005508_abnormal_skeleton_morphology1.54264108
33MP0003868_abnormal_feces_composition1.53261273
34MP0003453_abnormal_keratinocyte_physiol1.51177001
35MP0003828_pulmonary_edema1.51147381
36MP0001666_abnormal_nutrient_absorption1.46977729
37MP0002060_abnormal_skin_morphology1.46176563
38MP0000013_abnormal_adipose_tissue1.45311517
39MP0005595_abnormal_vascular_smooth1.43883764
40MP0002896_abnormal_bone_mineralization1.43429433
41MP0010030_abnormal_orbit_morphology1.41994525
42MP0005164_abnormal_response_to1.41575296
43MP0003045_fibrosis1.41318759
44MP0001542_abnormal_bone_strength1.38083883
45MP0000750_abnormal_muscle_regeneration1.36478770
46MP0002796_impaired_skin_barrier1.34002737
47MP0002139_abnormal_hepatobiliary_system1.33863323
48MP0005165_increased_susceptibility_to1.32401522
49MP0005365_abnormal_bile_salt1.32378785
50MP0010352_gastrointestinal_tract_polyps1.30879647
51MP0002108_abnormal_muscle_morphology1.24973061
52MP0004883_abnormal_blood_vessel1.23638335
53MP0002128_abnormal_blood_circulation1.22692916
54MP0006138_congestive_heart_failure1.21700342
55MP0005171_absent_coat_pigmentation1.21692892
56MP0005375_adipose_tissue_phenotype1.20454657
57MP0009250_abnormal_appendicular_skeleto1.18774250
58MP0000733_abnormal_muscle_development1.18540589
59MP0005360_urolithiasis1.17790836
60MP0010678_abnormal_skin_adnexa1.17430337
61MP0002877_abnormal_melanocyte_morpholog1.17160278
62MP0001614_abnormal_blood_vessel1.16961801
63MP0009379_abnormal_foot_pigmentation1.16801249
64MP0002925_abnormal_cardiovascular_devel1.14420074
65MP0002168_other_aberrant_phenotype1.13690236
66MP0001216_abnormal_epidermal_layer1.11734754
67MP0003385_abnormal_body_wall1.11162173
68MP0002138_abnormal_hepatobiliary_system1.10930804
69MP0000249_abnormal_blood_vessel1.10785878
70MP0005058_abnormal_lysosome_morphology1.10231831
71MP0004484_altered_response_of1.08972857
72MP0008875_abnormal_xenobiotic_pharmacok1.08926352
73MP0005408_hypopigmentation1.08648656
74MP0000163_abnormal_cartilage_morphology1.08258411
75MP0003300_gastrointestinal_ulcer1.07151336
76MP0000858_altered_metastatic_potential1.06543322
77MP0003942_abnormal_urinary_system1.06363981
78MP0005076_abnormal_cell_differentiation1.06095939
79MP0005388_respiratory_system_phenotype1.05348347
80MP0002133_abnormal_respiratory_system1.05348347
81MP0000534_abnormal_ureter_morphology1.03361701
82MP0005501_abnormal_skin_physiology1.03036794
83MP0001853_heart_inflammation1.02831979
84MP0010386_abnormal_urinary_bladder1.02821056
85MP0003941_abnormal_skin_development1.00761580
86MP0003252_abnormal_bile_duct0.99289222
87MP0000343_altered_response_to0.99239972
88MP0005085_abnormal_gallbladder_physiolo0.99020714
89MP0005084_abnormal_gallbladder_morpholo0.97958665
90MP0009697_abnormal_copulation0.95682454
91MP0000749_muscle_degeneration0.95676267
92MP0004782_abnormal_surfactant_physiolog0.93050686
93MP0001851_eye_inflammation0.92962536
94MP0003943_abnormal_hepatobiliary_system0.92476109
95MP0002972_abnormal_cardiac_muscle0.92308902
96MP0008260_abnormal_autophagy0.91962409
97MP0005390_skeleton_phenotype0.89292787
98MP0000627_abnormal_mammary_gland0.89245021
99MP0000762_abnormal_tongue_morphology0.88136457
100MP0005620_abnormal_muscle_contractility0.87056562
101MP0005330_cardiomyopathy0.86902600
102MP0001243_abnormal_dermal_layer0.85148287
103MP0001299_abnormal_eye_distance/0.82826705
104MP0008775_abnormal_heart_ventricle0.82282936
105MP0002249_abnormal_larynx_morphology0.81196466
106MP0009053_abnormal_anal_canal0.81035187
107MP0010630_abnormal_cardiac_muscle0.80995124
108MP0002086_abnormal_extraembryonic_tissu0.80917970
109MP0001348_abnormal_lacrimal_gland0.80472872
110MP0002115_abnormal_skeleton_extremities0.80370308
111MP0005166_decreased_susceptibility_to0.79976408
112MP0002933_joint_inflammation0.79620542
113MP0001544_abnormal_cardiovascular_syste0.79223672
114MP0005385_cardiovascular_system_phenoty0.79223672
115MP0005409_darkened_coat_color0.78970248
116MP0005332_abnormal_amino_acid0.78310542
117MP0005666_abnormal_adipose_tissue0.78107695
118MP0010234_abnormal_vibrissa_follicle0.78041507
119MP0000613_abnormal_salivary_gland0.77301255
120MP0002113_abnormal_skeleton_development0.76613498
121MP0002332_abnormal_exercise_endurance0.76599065
122MP0005197_abnormal_uvea_morphology0.76499224
123MP0002998_abnormal_bone_remodeling0.75734134
124MP0002166_altered_tumor_susceptibility0.75427997
125MP0002127_abnormal_cardiovascular_syste0.75168666
126MP0010771_integument_phenotype0.74623928
127MP0003937_abnormal_limbs/digits/tail_de0.73839440
128MP0004264_abnormal_extraembryonic_tissu0.73823419
129MP0004036_abnormal_muscle_relaxation0.73694404
130MP0000537_abnormal_urethra_morphology0.73631259
131MP0000049_abnormal_middle_ear0.73039649
132MP0005193_abnormal_anterior_eye0.72786500
133MP0005621_abnormal_cell_physiology0.72757548
134MP0008007_abnormal_cellular_replicative0.72273379
135MP0002932_abnormal_joint_morphology0.72208483
136MP0001175_abnormal_lung_morphology0.71947312
137MP0001533_abnormal_skeleton_physiology0.71012908
138MP0002089_abnormal_postnatal_growth/wei0.70897361
139MP0001661_extended_life_span0.70237414
140MP0000467_abnormal_esophagus_morphology0.70182013
141MP0000230_abnormal_systemic_arterial0.69511316
142MP0000751_myopathy0.69207298
143MP0003115_abnormal_respiratory_system0.68779172
144MP0000609_abnormal_liver_physiology0.68752211
145MP0009278_abnormal_bone_marrow0.68730009
146MP0002269_muscular_atrophy0.68513384
147MP0000516_abnormal_urinary_system0.67963255
148MP0005367_renal/urinary_system_phenotyp0.67963255
149MP0001915_intracranial_hemorrhage0.67612561
150MP0003935_abnormal_craniofacial_develop0.66719588
151MP0003448_altered_tumor_morphology0.66666011
152MP0005257_abnormal_intraocular_pressure0.66412933

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.96117506
2Protrusio acetabuli (HP:0003179)5.42051470
3Vascular calcification (HP:0004934)4.47847904
4Aortic aneurysm (HP:0004942)4.41925367
5Abnormal respiratory motile cilium physiology (HP:0012261)4.34876002
6Abnormal ciliary motility (HP:0012262)4.28702867
7Aortic dissection (HP:0002647)4.22187716
8Abnormality of dentin (HP:0010299)3.89601126
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.85873265
10Deep venous thrombosis (HP:0002625)3.83315897
11Atrophic scars (HP:0001075)3.79114921
12Rhinitis (HP:0012384)3.69202315
13Broad metatarsal (HP:0001783)3.69196338
14Shallow orbits (HP:0000586)3.55744380
15Spinal rigidity (HP:0003306)3.54612234
16Vascular tortuosity (HP:0004948)3.54261590
17Cerebral aneurysm (HP:0004944)3.46658384
18Short nail (HP:0001799)3.33559549
19Mitral stenosis (HP:0001718)3.25136624
20Ankle contracture (HP:0006466)3.20566837
21Nuclear cataract (HP:0100018)3.17347782
22Neonatal short-limb short stature (HP:0008921)3.10462109
23Tetraparesis (HP:0002273)3.08360013
24Increased connective tissue (HP:0009025)3.01525261
25Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98066891
26Short hallux (HP:0010109)2.97138283
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.94960936
28Follicular hyperkeratosis (HP:0007502)2.94175229
29Alopecia of scalp (HP:0002293)2.92250471
30Small epiphyses (HP:0010585)2.84568458
31Abnormality of the nasal mucosa (HP:0000433)2.81362239
32Soft skin (HP:0000977)2.81193834
33Arterial tortuosity (HP:0005116)2.79776980
34Abnormal respiratory motile cilium morphology (HP:0005938)2.76454408
35Abnormal respiratory epithelium morphology (HP:0012253)2.76454408
36Fragile skin (HP:0001030)2.76434932
37Pulmonary artery stenosis (HP:0004415)2.75454417
38Dilatation of the ascending aorta (HP:0005111)2.74319330
39Abnormality of the intrinsic pathway (HP:0010989)2.72635393
40Wormian bones (HP:0002645)2.72457567
41Aplasia/Hypoplasia of the hallux (HP:0008362)2.68473579
42Abnormality of carpal bone ossification (HP:0006257)2.68262799
43Abnormality of the nasal septum (HP:0000419)2.67586239
44Hematochezia (HP:0002573)2.64734461
45Cervical subluxation (HP:0003308)2.62872659
46Peritonitis (HP:0002586)2.62614255
47Bladder diverticulum (HP:0000015)2.60794064
48Hydroxyprolinuria (HP:0003080)2.59663991
49Abnormality of proline metabolism (HP:0010907)2.59663991
50Mesangial abnormality (HP:0001966)2.59245936
51Polycythemia (HP:0001901)2.53100185
52Venous abnormality (HP:0002624)2.51725738
53Abnormality of the common coagulation pathway (HP:0010990)2.50725089
54Aneurysm (HP:0002617)2.49454845
55Venous insufficiency (HP:0005293)2.46916681
56Focal segmental glomerulosclerosis (HP:0000097)2.45348607
57Abnormality of the Achilles tendon (HP:0005109)2.43782146
58Hypoplasia of the iris (HP:0007676)2.40246507
59Reduced subcutaneous adipose tissue (HP:0003758)2.38867230
60Glucose intolerance (HP:0000833)2.38137747
61Chronic bronchitis (HP:0004469)2.36394182
62Bronchomalacia (HP:0002780)2.35934796
63Mitral valve prolapse (HP:0001634)2.35777272
64Fat malabsorption (HP:0002630)2.32765283
65Flat acetabular roof (HP:0003180)2.32012432
66Prolonged partial thromboplastin time (HP:0003645)2.31970561
67Zonular cataract (HP:0010920)2.30240271
68Conjugated hyperbilirubinemia (HP:0002908)2.29738562
69Steatorrhea (HP:0002570)2.28331132
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.27283406
71Osteolytic defects of the hand bones (HP:0009699)2.27283406
72Congenital, generalized hypertrichosis (HP:0004540)2.26993588
73Hypobetalipoproteinemia (HP:0003563)2.26179236
74Bifid uvula (HP:0000193)2.25799924
75Pterygium (HP:0001059)2.23824231
76Stage 5 chronic kidney disease (HP:0003774)2.21711617
77Abnormality of the distal phalanges of the toes (HP:0010182)2.20826148
78Wrist flexion contracture (HP:0001239)2.20491020
79Chondrocalcinosis (HP:0000934)2.20230004
80Hypercholesterolemia (HP:0003124)2.18752914
81Joint hemorrhage (HP:0005261)2.17856883
82Menorrhagia (HP:0000132)2.17748328
83Complement deficiency (HP:0004431)2.17214950
84Overgrowth (HP:0001548)2.16547897
85Right ventricular cardiomyopathy (HP:0011663)2.16510650
86Blue sclerae (HP:0000592)2.15492556
87Coronal craniosynostosis (HP:0004440)2.15156469
88Trismus (HP:0000211)2.13812939
89Sparse eyelashes (HP:0000653)2.13360414
90Sensory axonal neuropathy (HP:0003390)2.12800567
91Abnormality of complement system (HP:0005339)2.11307914
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11030998
93Abnormality of the acetabulum (HP:0003170)2.10965189
94Abnormality of Sharpey fibers (HP:0100685)2.10003935
95Myocardial infarction (HP:0001658)2.08768477
96Abnormal ossification of hand bones (HP:0005921)2.07943752
97Scapular winging (HP:0003691)2.07761400
98Increased variability in muscle fiber diameter (HP:0003557)2.06731861
99Coxa vara (HP:0002812)2.05758139
100Back pain (HP:0003418)2.05664220
101Round ear (HP:0100830)2.05087055
102Abnormal tarsal ossification (HP:0008369)2.03875365
103Vertebral compression fractures (HP:0002953)2.00458444
104Glossoptosis (HP:0000162)1.99815357
105Hypolipoproteinemia (HP:0010981)1.99419523
106Submucous cleft hard palate (HP:0000176)1.97832692
107Onycholysis (HP:0001806)1.97037252
108Abnormal hand bone ossification (HP:0010660)1.95515205
109Aplasia involving bones of the extremities (HP:0009825)1.94642090
110Aplasia involving bones of the upper limbs (HP:0009823)1.94642090
111Aplasia of the phalanges of the hand (HP:0009802)1.94642090
112Distal upper limb amyotrophy (HP:0007149)1.93571027
113Upper limb amyotrophy (HP:0009129)1.93571027
114Abnormal delivery (HP:0001787)1.93354456
115Type 1 muscle fiber predominance (HP:0003803)1.93316443
116Achilles tendon contracture (HP:0001771)1.93027313
117Glomerulonephritis (HP:0000099)1.92664029
118Polar cataract (HP:0010696)1.92438624
119Mitral regurgitation (HP:0001653)1.92081492
120Lymphangioma (HP:0100764)1.92073281
121Abnormality of glycolysis (HP:0004366)1.91340180
122Camptodactyly of toe (HP:0001836)1.91216316
123Hypokinesia (HP:0002375)1.90937171
124Hemorrhage of the eye (HP:0011885)1.89679366
125Esophageal varix (HP:0002040)1.87823467
126Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87398178
127Increased density of long bones (HP:0006392)1.87207709
128Knee flexion contracture (HP:0006380)1.86522709
129Subacute progressive viral hepatitis (HP:0006572)1.86292424
130Hyperextensible skin (HP:0000974)1.84599315
131Mesomelia (HP:0003027)1.84166502
132Abnormality of skeletal muscle fiber size (HP:0012084)1.84010901
133Acanthosis nigricans (HP:0000956)1.83239320
134Biconcave vertebral bodies (HP:0004586)1.83184338
135Nonimmune hydrops fetalis (HP:0001790)1.81575012
136Muscle fiber splitting (HP:0003555)1.80665328
137Glomerulosclerosis (HP:0000096)1.79691860
138Increased serum pyruvate (HP:0003542)1.79613740
139Exocrine pancreatic insufficiency (HP:0001738)1.79396548
140Tubular atrophy (HP:0000092)1.78627517
141Cardiovascular calcification (HP:0011915)1.78536562
142Bell-shaped thorax (HP:0001591)1.77019904
143Broad face (HP:0000283)1.76829640
144Subcapsular cataract (HP:0000523)1.76003938
145Wide anterior fontanel (HP:0000260)1.74378221
146Bronchiectasis (HP:0002110)1.73037824
147Distal lower limb muscle weakness (HP:0009053)1.72665966
148Asymmetry of the thorax (HP:0001555)1.72490347
149Hepatocellular carcinoma (HP:0001402)1.72240084
150Chronic sinusitis (HP:0011109)1.71582569
151Abnormality of the anterior chamber (HP:0000593)1.71572370
152Axonal loss (HP:0003447)1.70341636
153Hyporeflexia of lower limbs (HP:0002600)1.70277530
154Absent toe (HP:0010760)1.70159073
155Spondylolisthesis (HP:0003302)1.69578796
156Micronodular cirrhosis (HP:0001413)1.68297193
157Hypophosphatemic rickets (HP:0004912)1.67475934
158Striae distensae (HP:0001065)1.66840330
159Femoral bowing (HP:0002980)1.66282680
160Joint laxity (HP:0001388)1.65723090
161Nasal polyposis (HP:0100582)1.65313757
162Xanthomatosis (HP:0000991)1.65210420
163Elbow flexion contracture (HP:0002987)1.65185788
164Hypoalbuminemia (HP:0003073)1.65030687
165Abnormal albumin level (HP:0012116)1.65030687
166Distal lower limb amyotrophy (HP:0008944)1.64438875
167Difficulty climbing stairs (HP:0003551)1.63134902
168Fused cervical vertebrae (HP:0002949)1.63035551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.77520853
2KDR3.46784566
3EPHA23.09720706
4TTN3.08724857
5EPHB22.85222723
6TGFBR22.84423256
7MYLK2.73214544
8MAP3K122.66316976
9DDR22.63055059
10PDGFRA2.48995089
11LATS12.48792821
12MAPK152.37644578
13PAK22.29914042
14IRAK32.25110590
15LMTK22.20444564
16SIK32.17482997
17BRSK22.16853457
18FER2.15356921
19TRPM72.11766293
20TGFBR12.04560856
21MST41.97373697
22LATS21.90020082
23PTK2B1.86479782
24ERBB41.84071925
25FRK1.80630333
26DMPK1.75572936
27EPHA31.71673478
28LRRK21.71658420
29RIPK11.65086641
30EIF2AK11.58729176
31PTK21.58580880
32EIF2AK31.55405076
33PAK41.54454051
34TRIB31.45549191
35MAP3K31.42353671
36ERN11.40999348
37TRIM281.39045046
38PAK31.35576796
39CDK81.34821142
40ARAF1.34464537
41EPHB11.30516562
42PTK61.26655821
43SIK11.25671684
44MET1.25188256
45ERBB31.22996963
46ROCK11.22179089
47PBK1.19003410
48NEK91.18373617
49MOS1.18071983
50BMX1.17052562
51ICK1.13101381
52BRSK11.10746650
53WNK41.09535116
54PIM21.05725124
55STK101.04721460
56TESK11.03785788
57PDK21.02542988
58NUAK11.02063148
59PRKG21.01007122
60MAP3K91.00790548
61NEK10.99817201
62GRK10.99039019
63LIMK10.98195359
64WEE10.98028314
65RPS6KA40.97788176
66STK390.94294467
67STK30.88068528
68PDGFRB0.87541695
69GSK3A0.86741582
70ROCK20.86534391
71NME20.85030168
72STK380.83407336
73MAP2K10.82442992
74MST1R0.81914565
75PRKD10.81450362
76MAP3K130.78765320
77MAPKAPK30.78272990
78PIK3CA0.77854920
79ILK0.76357940
80PRKD20.71956633
81ZAK0.69906711
82NEK60.69198175
83INSR0.67052804
84PKN20.64064591
85PRKCE0.63606933
86MAP2K30.62102032
87AKT30.61526683
88CDK120.59270703
89TAOK20.58490098
90STK240.58143128
91KSR10.57625921
92STK38L0.56296880
93IGF1R0.54537114
94CSK0.53840944
95ABL20.53517733
96FGFR20.52708156
97FGFR10.52618212
98MAP2K20.52044393
99BCR0.51206873
100MTOR0.50546105
101BMPR20.49999873
102PRKCH0.49944698
103WNK10.48593950
104FLT30.48298712
105MAPKAPK50.47174109
106FGFR30.46669549
107NTRK10.44517421
108SRC0.43590233
109OXSR10.43077399
110ADRBK10.42952932
111CDK60.42280072
112PRKCI0.42033109
113EGFR0.40499670
114MAPKAPK20.39879951
115JAK10.39566275
116AKT20.39518592
117MAPK120.39081230
118FGFR40.38862716
119PIK3CG0.38112506
120PDPK10.38021456
121PLK20.37731864
122MELK0.36916086
123CDC42BPA0.36850117
124MAP3K20.36755865
125ABL10.36623672
126MAPK70.35481944
127NLK0.34825796
128MAP3K10.34344649
129TSSK60.33834893
130MATK0.32696462
131MAP3K80.32179445
132EEF2K0.31228912
133YES10.28735195
134MAP3K140.28658218
135MAPK110.28561691
136DAPK10.28465568
137ERBB20.28382266
138PRKAA20.27570455
139RPS6KB20.27333593
140DAPK30.26530250
141CAMKK20.26150905
142RET0.25285139
143DYRK1B0.25205314
144PAK10.24414229
145TBK10.23326284

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.30186693
2Focal adhesion_Homo sapiens_hsa045103.37191530
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65803189
4Adherens junction_Homo sapiens_hsa045202.57167555
5Malaria_Homo sapiens_hsa051442.52344933
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.40087735
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.39293700
8Proteoglycans in cancer_Homo sapiens_hsa052052.37218683
9Dilated cardiomyopathy_Homo sapiens_hsa054142.31363576
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.25752178
11Small cell lung cancer_Homo sapiens_hsa052222.21782001
12TGF-beta signaling pathway_Homo sapiens_hsa043502.14806345
13Amoebiasis_Homo sapiens_hsa051462.04254505
14Leukocyte transendothelial migration_Homo sapiens_hsa046702.02610477
15Fructose and mannose metabolism_Homo sapiens_hsa000511.97546073
16Arginine biosynthesis_Homo sapiens_hsa002201.90088290
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89108173
18Circadian rhythm_Homo sapiens_hsa047101.88153449
19Galactose metabolism_Homo sapiens_hsa000521.81069782
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78650300
21Nitrogen metabolism_Homo sapiens_hsa009101.76504455
22Hippo signaling pathway_Homo sapiens_hsa043901.73583149
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.71549925
24Bladder cancer_Homo sapiens_hsa052191.68963959
25N-Glycan biosynthesis_Homo sapiens_hsa005101.68446618
26Protein digestion and absorption_Homo sapiens_hsa049741.66417142
27Tight junction_Homo sapiens_hsa045301.63738856
28Other glycan degradation_Homo sapiens_hsa005111.55615997
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53043561
30Rap1 signaling pathway_Homo sapiens_hsa040151.50425063
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.47628171
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45453816
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43482458
34Sulfur metabolism_Homo sapiens_hsa009201.41920379
35Viral myocarditis_Homo sapiens_hsa054161.41575923
36Biosynthesis of amino acids_Homo sapiens_hsa012301.38207673
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35514904
38Axon guidance_Homo sapiens_hsa043601.34460250
39MicroRNAs in cancer_Homo sapiens_hsa052061.34391884
40Phenylalanine metabolism_Homo sapiens_hsa003601.31484037
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30767555
42Platelet activation_Homo sapiens_hsa046111.27412979
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27123075
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25172935
45TNF signaling pathway_Homo sapiens_hsa046681.25092953
46Starch and sucrose metabolism_Homo sapiens_hsa005001.24858434
47Pentose phosphate pathway_Homo sapiens_hsa000301.23696360
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22533432
49Pathways in cancer_Homo sapiens_hsa052001.22405855
50Sphingolipid metabolism_Homo sapiens_hsa006001.18505542
51Melanoma_Homo sapiens_hsa052181.17569799
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.16569938
53Arginine and proline metabolism_Homo sapiens_hsa003301.07868246
54Basal cell carcinoma_Homo sapiens_hsa052171.06373541
55Steroid biosynthesis_Homo sapiens_hsa001001.05982294
56Fat digestion and absorption_Homo sapiens_hsa049751.05792332
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05705564
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05335906
59Proteasome_Homo sapiens_hsa030501.04820181
60Pancreatic secretion_Homo sapiens_hsa049721.03333343
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02207150
62Toxoplasmosis_Homo sapiens_hsa051451.02190159
63Renal cell carcinoma_Homo sapiens_hsa052111.02072084
64Prostate cancer_Homo sapiens_hsa052150.99912804
65Complement and coagulation cascades_Homo sapiens_hsa046100.96895682
66Ras signaling pathway_Homo sapiens_hsa040140.96720195
67African trypanosomiasis_Homo sapiens_hsa051430.96290906
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95084891
69Ovarian steroidogenesis_Homo sapiens_hsa049130.94945388
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93231251
71Dorso-ventral axis formation_Homo sapiens_hsa043200.93039708
72Vibrio cholerae infection_Homo sapiens_hsa051100.92122831
73Gap junction_Homo sapiens_hsa045400.89752322
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88593551
75Legionellosis_Homo sapiens_hsa051340.88252742
76Shigellosis_Homo sapiens_hsa051310.86148667
77HIF-1 signaling pathway_Homo sapiens_hsa040660.86041542
78Salmonella infection_Homo sapiens_hsa051320.85622979
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83222269
80Vitamin B6 metabolism_Homo sapiens_hsa007500.82826295
81Pancreatic cancer_Homo sapiens_hsa052120.81505042
82Wnt signaling pathway_Homo sapiens_hsa043100.81377591
83Chronic myeloid leukemia_Homo sapiens_hsa052200.80862462
84Fatty acid biosynthesis_Homo sapiens_hsa000610.79673596
85Carbon metabolism_Homo sapiens_hsa012000.76674051
86Protein export_Homo sapiens_hsa030600.76298438
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76186774
88Rheumatoid arthritis_Homo sapiens_hsa053230.75338711
89Notch signaling pathway_Homo sapiens_hsa043300.74967060
90Tyrosine metabolism_Homo sapiens_hsa003500.73764421
91HTLV-I infection_Homo sapiens_hsa051660.72632725
92Phagosome_Homo sapiens_hsa041450.72316623
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70920588
94Estrogen signaling pathway_Homo sapiens_hsa049150.70894604
95Melanogenesis_Homo sapiens_hsa049160.70384657
96PPAR signaling pathway_Homo sapiens_hsa033200.68115720
97Selenocompound metabolism_Homo sapiens_hsa004500.65760811
98Thyroid hormone synthesis_Homo sapiens_hsa049180.65504347
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64954147
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64755924
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62234289
102Hedgehog signaling pathway_Homo sapiens_hsa043400.61956297
103Hematopoietic cell lineage_Homo sapiens_hsa046400.60542884
104Chemical carcinogenesis_Homo sapiens_hsa052040.59278687
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58558268
106Pertussis_Homo sapiens_hsa051330.57810147
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57798659
108Pyruvate metabolism_Homo sapiens_hsa006200.57546233
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57501621
110VEGF signaling pathway_Homo sapiens_hsa043700.57497740
111Renin-angiotensin system_Homo sapiens_hsa046140.56926949
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56650464
113Apoptosis_Homo sapiens_hsa042100.56598585
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56004177
115Folate biosynthesis_Homo sapiens_hsa007900.55311064
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52334131
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.52265774
118Renin secretion_Homo sapiens_hsa049240.52078074
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51502655
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50820532
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50309982
122Glioma_Homo sapiens_hsa052140.50056631
123Glucagon signaling pathway_Homo sapiens_hsa049220.49892480
124Mineral absorption_Homo sapiens_hsa049780.49528711
125Endocytosis_Homo sapiens_hsa041440.49500637
126Vitamin digestion and absorption_Homo sapiens_hsa049770.49143327
127GnRH signaling pathway_Homo sapiens_hsa049120.48412301
128Hepatitis C_Homo sapiens_hsa051600.46545887
129Oxytocin signaling pathway_Homo sapiens_hsa049210.46355377
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46148176
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.44513481
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.44337024
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44335496
134ErbB signaling pathway_Homo sapiens_hsa040120.44047003
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43956988
136MAPK signaling pathway_Homo sapiens_hsa040100.43917812
137Arachidonic acid metabolism_Homo sapiens_hsa005900.42661200
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.41806338
139Thyroid cancer_Homo sapiens_hsa052160.40946995
140Bile secretion_Homo sapiens_hsa049760.40891024
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.40764268
142Lysosome_Homo sapiens_hsa041420.38313781
143Insulin resistance_Homo sapiens_hsa049310.37032930
144Gastric acid secretion_Homo sapiens_hsa049710.36918917
145p53 signaling pathway_Homo sapiens_hsa041150.36385350
146Endometrial cancer_Homo sapiens_hsa052130.34269511
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.33800510
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33063417
149Glutathione metabolism_Homo sapiens_hsa004800.31800045
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31316232
151Prion diseases_Homo sapiens_hsa050200.31229138

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