TM4SF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiogenesis involved in wound healing (GO:0060055)8.14437095
2blood vessel maturation (GO:0001955)7.57083598
3sprouting angiogenesis (GO:0002040)7.45502609
4lymphangiogenesis (GO:0001946)6.97537902
5positive regulation of vasculogenesis (GO:2001214)6.74735294
6vascular endothelial growth factor signaling pathway (GO:0038084)6.20566668
7regulation of vasculogenesis (GO:2001212)6.12305292
8endothelial tube morphogenesis (GO:0061154)5.85377164
9morphogenesis of an endothelium (GO:0003159)5.85377164
10negative regulation of blood vessel endothelial cell migration (GO:0043537)5.79063781
11lymph vessel development (GO:0001945)5.55647935
12retina vasculature morphogenesis in camera-type eye (GO:0061299)5.53041719
13endothelial cell proliferation (GO:0001935)5.48722697
14cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.16045075
15proteasome assembly (GO:0043248)4.80037561
16endothelial cell differentiation (GO:0045446)4.75802801
17positive regulation of odontogenesis (GO:0042482)4.74096997
18regulation of endothelial cell differentiation (GO:0045601)4.53235037
19regulation of sarcomere organization (GO:0060297)4.44082000
20artery development (GO:0060840)4.43136597
21Notch signaling involved in heart development (GO:0061314)4.34920610
22labyrinthine layer development (GO:0060711)4.32968628
23patterning of blood vessels (GO:0001569)4.26383646
24thrombin receptor signaling pathway (GO:0070493)4.16276418
25basement membrane organization (GO:0071711)4.14134206
26positive regulation of cell junction assembly (GO:1901890)4.13918019
27positive regulation of focal adhesion assembly (GO:0051894)4.13918019
28negative regulation of endothelial cell migration (GO:0010596)4.06741470
29wound healing, spreading of epidermal cells (GO:0035313)4.03378574
30regulation of blood vessel endothelial cell migration (GO:0043535)3.96346251
31ventricular trabecula myocardium morphogenesis (GO:0003222)3.91098484
32positive regulation of endothelial cell differentiation (GO:0045603)3.89896525
33establishment of endothelial barrier (GO:0061028)3.80126004
34positive regulation of adherens junction organization (GO:1903393)3.76572712
35heart trabecula morphogenesis (GO:0061384)3.72011499
36negative regulation of endothelial cell apoptotic process (GO:2000352)3.69852947
37angiogenesis (GO:0001525)3.68901933
38positive regulation of urine volume (GO:0035810)3.63522546
39heart trabecula formation (GO:0060347)3.62329419
40histamine secretion (GO:0001821)3.61792657
41cell migration involved in sprouting angiogenesis (GO:0002042)3.60815971
42regulation of chemokine-mediated signaling pathway (GO:0070099)3.60394682
43regulation of endothelial cell migration (GO:0010594)3.59637915
44glomerular filtration (GO:0003094)3.59074125
45heme transport (GO:0015886)3.59073699
46trabecula morphogenesis (GO:0061383)3.54484784
47positive regulation of cell size (GO:0045793)3.54472763
48artery smooth muscle contraction (GO:0014824)3.48701549
49vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.47275329
50gap junction assembly (GO:0016264)3.46270299
51heart valve formation (GO:0003188)3.39954216
52negative regulation of glycogen biosynthetic process (GO:0045719)3.36838849
53regulation of integrin-mediated signaling pathway (GO:2001044)3.32839597
54renal filtration (GO:0097205)3.32136539
55negative regulation of protein autophosphorylation (GO:0031953)3.27382234
56histamine transport (GO:0051608)3.27337276
57tonic smooth muscle contraction (GO:0014820)3.26118647
58platelet dense granule organization (GO:0060155)3.25484326
59terpenoid biosynthetic process (GO:0016114)3.19534019
60regulation of establishment or maintenance of cell polarity (GO:0032878)3.19504689
61inositol phosphate-mediated signaling (GO:0048016)3.15214062
62regulation of endothelial cell apoptotic process (GO:2000351)3.13261835
63regulation of positive chemotaxis (GO:0050926)3.12380219
64substrate adhesion-dependent cell spreading (GO:0034446)3.11832785
65regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.10280952
66embryonic heart tube development (GO:0035050)3.07298425
67positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.05467473
68vasculogenesis (GO:0001570)3.04309895
69regulation of cell-substrate junction assembly (GO:0090109)3.02127896
70regulation of focal adhesion assembly (GO:0051893)3.02127896
71blood vessel endothelial cell migration (GO:0043534)3.02051573
72mRNA transcription from RNA polymerase II promoter (GO:0042789)3.01983402
73negative regulation of epithelial cell migration (GO:0010633)3.00321172
74negative regulation of vascular permeability (GO:0043116)2.96103183
75ether lipid metabolic process (GO:0046485)2.96070266
76transcytosis (GO:0045056)2.95819380
77regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.95511065
78atrial cardiac muscle cell action potential (GO:0086014)2.94406255
79negative regulation of axon extension involved in axon guidance (GO:0048843)2.92923868
80negative regulation of focal adhesion assembly (GO:0051895)2.90748850
81negative regulation of cell junction assembly (GO:1901889)2.90748850
82negative regulation of adherens junction organization (GO:1903392)2.90748850
83nephron epithelium development (GO:0072009)2.90047522
84Rap protein signal transduction (GO:0032486)2.87460295
85regulation of adherens junction organization (GO:1903391)2.85971931
86organ formation (GO:0048645)2.83852081
87negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.83642055
88negative regulation of protein localization to cell surface (GO:2000009)2.83575873
89endothelial cell morphogenesis (GO:0001886)2.81592166
90positive regulation of endothelial cell migration (GO:0010595)2.81476679
91heparin metabolic process (GO:0030202)2.79518066
92heparin biosynthetic process (GO:0030210)2.79518066
93phospholipid homeostasis (GO:0055091)2.79428526
94regulation of vascular permeability (GO:0043114)2.78493605
95negative regulation of DNA biosynthetic process (GO:2000279)2.73880307
96endoderm formation (GO:0001706)2.73184254
97triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.71661580
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71633412
99negative regulation of angiogenesis (GO:0016525)2.69855057
100endothelium development (GO:0003158)11.6737912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_21666600_ChIP-Seq_HMVEC_Human5.35014618
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.50248929
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.41373167
4VDR_22108803_ChIP-Seq_LS180_Human2.79892093
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.71978890
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.60324502
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46322715
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.45325786
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41356104
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.32944545
11ELK1_19687146_ChIP-ChIP_HELA_Human2.28003991
12* CJUN_26792858_Chip-Seq_BT549_Human2.22764804
13SALL4_18804426_ChIP-ChIP_XEN_Mouse2.16356857
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.13648335
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08008084
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06957446
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05483125
18* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03635457
19BCAT_22108803_ChIP-Seq_LS180_Human1.88174006
20P300_19829295_ChIP-Seq_ESCs_Human1.81934695
21CDX2_22108803_ChIP-Seq_LS180_Human1.71770046
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69939719
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68432881
24EWS_26573619_Chip-Seq_HEK293_Human1.66480949
25* BRD4_25478319_ChIP-Seq_HGPS_Human1.65460078
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63692170
27GBX2_23144817_ChIP-Seq_PC3_Human1.58370039
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.55121542
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54791647
30* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53568868
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52940850
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51034438
33TCF4_22108803_ChIP-Seq_LS180_Human1.50826722
34* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48027913
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.45041769
36AHR_22903824_ChIP-Seq_MCF-7_Human1.44443763
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43182534
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43049313
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43049313
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39581998
41SOX2_20726797_ChIP-Seq_SW620_Human1.39372132
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.31802040
43* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30767086
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30325487
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.29642663
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26325976
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26325976
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26325976
49ZNF274_21170338_ChIP-Seq_K562_Hela1.24493590
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22897263
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22897263
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.22202535
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.20709619
54* GATA4_25053715_ChIP-Seq_YYC3_Human1.20696538
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19340285
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.16135441
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.15820679
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13470824
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12766628
60TP53_18474530_ChIP-ChIP_U2OS_Human1.12746830
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.12420027
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12075153
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.11989487
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09227869
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.08819652
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06334769
67SOX2_19829295_ChIP-Seq_ESCs_Human1.05407623
68NANOG_19829295_ChIP-Seq_ESCs_Human1.05407623
69* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04892549
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04577176
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.03759234
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03298573
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.03237981
74TP63_23658742_ChIP-Seq_EP156T_Human1.01677847
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.00437420
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.00437420
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00095662
78TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99429677
79MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98890025
80RUNX2_22187159_ChIP-Seq_PCA_Human0.98781444
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98377283
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98052263
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97746260
84FUS_26573619_Chip-Seq_HEK293_Human0.96441550
85TAF15_26573619_Chip-Seq_HEK293_Human0.96121260
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96048991
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95288178
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94478474
89CBP_20019798_ChIP-Seq_JUKART_Human0.94478474
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.93121526
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92480767
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91329138
93CBP_21632823_ChIP-Seq_H3396_Human0.91154946
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90526068
95* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90124641
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.90099279
97AR_20517297_ChIP-Seq_VCAP_Human0.89887824
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.89844470
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89498603
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87069239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.47388478
2MP0001879_abnormal_lymphatic_vessel6.96482962
3MP0006054_spinal_hemorrhage6.30012045
4MP0004272_abnormal_basement_membrane5.09795460
5MP0005167_abnormal_blood-brain_barrier4.22971014
6MP0003195_calcinosis4.06936114
7MP0002138_abnormal_hepatobiliary_system3.58440809
8MP0003828_pulmonary_edema2.58787755
9MP0003950_abnormal_plasma_membrane2.57801357
10MP0000767_abnormal_smooth_muscle2.50001729
11MP0005084_abnormal_gallbladder_morpholo2.39704745
12MP0000465_gastrointestinal_hemorrhage2.31436100
13MP0004484_altered_response_of2.20497897
14MP0005165_increased_susceptibility_to2.16975706
15MP0003724_increased_susceptibility_to1.95190685
16MP0005595_abnormal_vascular_smooth1.91359748
17MP0004215_abnormal_myocardial_fiber1.84869099
18MP0006138_congestive_heart_failure1.84435561
19MP0003279_aneurysm1.79171398
20MP0002127_abnormal_cardiovascular_syste1.65632350
21MP0001915_intracranial_hemorrhage1.63402681
22MP0002332_abnormal_exercise_endurance1.52068070
23MP0001614_abnormal_blood_vessel1.51890678
24MP0002972_abnormal_cardiac_muscle1.44446931
25MP0002925_abnormal_cardiovascular_devel1.41778845
26MP0004084_abnormal_cardiac_muscle1.40551923
27MP0003943_abnormal_hepatobiliary_system1.28972319
28MP0005620_abnormal_muscle_contractility1.28250489
29MP0003566_abnormal_cell_adhesion1.27781239
30MP0005085_abnormal_gallbladder_physiolo1.25200086
31MP0000003_abnormal_adipose_tissue1.23868894
32MP0003011_delayed_dark_adaptation1.23180349
33MP0000013_abnormal_adipose_tissue1.21838245
34MP0000249_abnormal_blood_vessel1.19933684
35MP0002128_abnormal_blood_circulation1.19433543
36MP0005670_abnormal_white_adipose1.18192046
37MP0005367_renal/urinary_system_phenotyp1.17830529
38MP0000516_abnormal_urinary_system1.17830529
39MP0005330_cardiomyopathy1.14138363
40MP0001544_abnormal_cardiovascular_syste1.13944962
41MP0005385_cardiovascular_system_phenoty1.13944962
42MP0010234_abnormal_vibrissa_follicle1.13078048
43MP0002168_other_aberrant_phenotype1.12951952
44MP0005187_abnormal_penis_morphology1.06798483
45MP0004085_abnormal_heartbeat1.06645329
46MP0000749_muscle_degeneration1.05987289
47MP0000230_abnormal_systemic_arterial0.99806251
48MP0002933_joint_inflammation0.94911008
49MP0003941_abnormal_skin_development0.94818871
50MP0005623_abnormal_meninges_morphology0.93552280
51MP0008775_abnormal_heart_ventricle0.93353687
52MP0006276_abnormal_autonomic_nervous0.92840283
53MP0004036_abnormal_muscle_relaxation0.91339714
54MP0003984_embryonic_growth_retardation0.91216370
55MP0002086_abnormal_extraembryonic_tissu0.90439630
56MP0002088_abnormal_embryonic_growth/wei0.89422168
57MP0000467_abnormal_esophagus_morphology0.82804936
58MP0001784_abnormal_fluid_regulation0.81616344
59MP0002295_abnormal_pulmonary_circulatio0.81509236
60MP0000266_abnormal_heart_morphology0.80858829
61MP0009697_abnormal_copulation0.79186793
62MP0010630_abnormal_cardiac_muscle0.78335483
63MP0010678_abnormal_skin_adnexa0.77330037
64MP0000537_abnormal_urethra_morphology0.73064188
65MP0001191_abnormal_skin_condition0.72205828
66MP0000613_abnormal_salivary_gland0.69238707
67MP0003638_abnormal_response/metabolism_0.67115600
68MP0003186_abnormal_redox_activity0.67022312
69MP0005395_other_phenotype0.66613259
70MP0003091_abnormal_cell_migration0.65737550
71MP0002928_abnormal_bile_duct0.64870157
72MP0009053_abnormal_anal_canal0.64195618
73MP0005380_embryogenesis_phenotype0.62188881
74MP0001672_abnormal_embryogenesis/_devel0.62188881
75MP0003868_abnormal_feces_composition0.62114379
76MP0004019_abnormal_vitamin_homeostasis0.60202693
77MP0004782_abnormal_surfactant_physiolog0.60037245
78MP0000647_abnormal_sebaceous_gland0.58632658
79MP0002736_abnormal_nociception_after0.57959348
80MP0001485_abnormal_pinna_reflex0.56214598
81MP0005083_abnormal_biliary_tract0.55045359
82MP0004145_abnormal_muscle_electrophysio0.54798399
83MP0003935_abnormal_craniofacial_develop0.52838413
84MP0005375_adipose_tissue_phenotype0.52715059
85MP0002896_abnormal_bone_mineralization0.52598221
86MP0003119_abnormal_digestive_system0.50499766
87MP0000751_myopathy0.50442181
88MP0001756_abnormal_urination0.48525957
89MP0004147_increased_porphyrin_level0.48166254
90MP0005197_abnormal_uvea_morphology0.47986571
91MP0004885_abnormal_endolymph0.47968165
92MP0004233_abnormal_muscle_weight0.46482353
93MP0003633_abnormal_nervous_system0.42882859
94MP0002638_abnormal_pupillary_reflex0.42801597
95MP0008007_abnormal_cellular_replicative0.42713961
96MP0003045_fibrosis0.42223761
97MP0002133_abnormal_respiratory_system0.42206844
98MP0005388_respiratory_system_phenotype0.42206844
99MP0005193_abnormal_anterior_eye0.41709998
100MP0000762_abnormal_tongue_morphology0.41432251

Predicted human phenotypes

RankGene SetZ-score
1Stenosis of the external auditory canal (HP:0000402)6.82050742
2Myocardial infarction (HP:0001658)4.71635056
3Hematochezia (HP:0002573)4.68733307
4Cerebral hemorrhage (HP:0001342)4.64080582
5Nonimmune hydrops fetalis (HP:0001790)4.38693327
6Hyperlipoproteinemia (HP:0010980)4.05737512
7Tetraparesis (HP:0002273)3.95767839
8Delayed CNS myelination (HP:0002188)3.76222002
9Nuclear cataract (HP:0100018)3.70639520
10Congenital, generalized hypertrichosis (HP:0004540)3.69942391
11Arterial tortuosity (HP:0005116)3.51712541
12Abnormality of macular pigmentation (HP:0008002)3.49744332
13Spontaneous hematomas (HP:0007420)3.47559992
14Vascular calcification (HP:0004934)3.41392476
15Lymphangioma (HP:0100764)3.35207429
16Esophageal varix (HP:0002040)3.32633186
17Hypophosphatemic rickets (HP:0004912)3.30784939
18Cardiovascular calcification (HP:0011915)3.00126087
19Polycythemia (HP:0001901)2.99853542
20Large for gestational age (HP:0001520)2.96180460
21Portal hypertension (HP:0001409)2.87328770
22Vascular tortuosity (HP:0004948)2.86724969
23Hyporeflexia of lower limbs (HP:0002600)2.86041283
24Glossoptosis (HP:0000162)2.85367053
25Wrist flexion contracture (HP:0001239)2.85189216
26Muscle fiber splitting (HP:0003555)2.81034096
27Adactyly (HP:0009776)2.78938993
28Conjunctival telangiectasia (HP:0000524)2.71702903
29Absent eyebrow (HP:0002223)2.59777492
30Abnormality of proline metabolism (HP:0010907)2.59622895
31Hydroxyprolinuria (HP:0003080)2.59622895
32Abnormality of the hepatic vasculature (HP:0006707)2.56318477
33Exercise-induced muscle cramps (HP:0003710)2.51724892
34Capillary hemangiomas (HP:0005306)2.50729259
35Porencephaly (HP:0002132)2.49190354
36Parakeratosis (HP:0001036)2.49151020
37Hypoplasia of the uterus (HP:0000013)2.46060202
38Skull defect (HP:0001362)2.45828379
39Amniotic constriction ring (HP:0009775)2.39651609
40Abnormality of placental membranes (HP:0011409)2.39651609
41Aortic valve stenosis (HP:0001650)2.37571258
42Mitral stenosis (HP:0001718)2.28606236
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27047969
44Scotoma (HP:0000575)2.24584165
45Bifid uvula (HP:0000193)2.21515354
46Facial diplegia (HP:0001349)2.20722037
47Muscle fibrillation (HP:0010546)2.20306383
48Increased corneal curvature (HP:0100692)2.14902506
49Keratoconus (HP:0000563)2.14902506
50Cavernous hemangioma (HP:0001048)2.13007321
51Vertebral clefting (HP:0008428)2.11441817
52Lymphedema (HP:0001004)2.10642567
53Absent eyelashes (HP:0000561)2.08715168
54Palpebral edema (HP:0100540)2.08332010
55Aplasia/hypoplasia of the uterus (HP:0008684)2.08310767
56Zonular cataract (HP:0010920)2.06846535
57Cone-rod dystrophy (HP:0000548)2.06787287
58Areflexia of lower limbs (HP:0002522)2.01335827
59EMG: myopathic abnormalities (HP:0003458)2.00331435
60Short hallux (HP:0010109)1.99941156
61Intrahepatic cholestasis (HP:0001406)1.99412286
62Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99055459
63Increased serum pyruvate (HP:0003542)1.96750755
64High pitched voice (HP:0001620)1.96346872
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.95642543
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93105416
67Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90974420
68Methylmalonic aciduria (HP:0012120)1.89843180
69Atrioventricular block (HP:0001678)1.88392223
70Degeneration of anterior horn cells (HP:0002398)1.87254341
71Abnormality of the anterior horn cell (HP:0006802)1.87254341
72Choroideremia (HP:0001139)1.86066321
73Congenital ichthyosiform erythroderma (HP:0007431)1.84201522
74Abnormality of the nasal mucosa (HP:0000433)1.82879745
75Centrally nucleated skeletal muscle fibers (HP:0003687)1.82059733
76Spinal rigidity (HP:0003306)1.81410697
77Cerebral aneurysm (HP:0004944)1.80657677
78Spinal muscular atrophy (HP:0007269)1.79822532
79Vertebral hypoplasia (HP:0008417)1.79091467
80Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79091467
81Aplasia/Hypoplasia of the hallux (HP:0008362)1.74493449
82Visceral angiomatosis (HP:0100761)1.72438153
83Hydroureter (HP:0000072)1.71842649
84Dry hair (HP:0011359)1.69802529
85Nemaline bodies (HP:0003798)1.69308846
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68006981
87Full cheeks (HP:0000293)1.67983339
88Abnormality of methionine metabolism (HP:0010901)1.67855432
89Heart block (HP:0012722)1.67564604
90Subcapsular cataract (HP:0000523)1.66434692
91Hemangiomatosis (HP:0007461)1.63851984
92Decreased central vision (HP:0007663)1.62573683
93Pendular nystagmus (HP:0012043)1.62243206
94Hypothermia (HP:0002045)1.62180894
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61761793
96Absent epiphyses (HP:0010577)1.61761793
97Fibular aplasia (HP:0002990)1.60963216
98Woolly hair (HP:0002224)1.59857683
99Attenuation of retinal blood vessels (HP:0007843)1.58868266
100J-shaped sella turcica (HP:0002680)1.58841052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.78069804
2MAP3K123.76009455
3MST43.22233943
4MYLK2.28106652
5EPHB22.26695465
6EIF2AK32.26295173
7FER2.19734949
8TIE111.4735908
9STK391.84696982
10BMPR1B1.81185545
11SIK31.61804177
12PDK21.50797699
13PAK41.50595679
14TRIM281.46732331
15EPHA21.32929856
16BRSK21.30796572
17TGFBR21.29513170
18MET1.28180049
19MAP3K91.28048737
20PTK2B1.26035476
21OXSR11.23727743
22TEC1.21011211
23GRK11.20205333
24FRK1.10591407
25FES1.10564771
26PLK21.08440443
27TGFBR11.01608170
28ILK1.00837706
29ROCK10.99255764
30PTK20.97229748
31STK100.90827777
32TSSK60.87143038
33BCR0.86109182
34MAP3K130.84831140
35VRK20.83496870
36CDK80.77904561
37PRKG20.76180521
38ARAF0.75939937
39NEK90.74575326
40PLK30.73653197
41MOS0.73383198
42MKNK20.72473718
43WEE10.69482854
44ERBB40.67101295
45ROCK20.66154867
46PBK0.62393094
47EIF2AK10.59422902
48LIMK10.57122012
49PRKCE0.55112514
50TAF10.54431420
51YES10.54280386
52MAP3K30.52956086
53LATS20.51732400
54VRK10.51477867
55TESK10.47732372
56NTRK10.47611545
57MST1R0.47535237
58NUAK10.47336436
59ABL20.46195289
60PINK10.46132804
61FLT30.40631997
62BRSK10.39844534
63CASK0.39197088
64IGF1R0.38830310
65AKT30.37183243
66TNIK0.37072798
67SRPK10.34836925
68TRPM70.34411001
69BUB10.34132725
70EGFR0.33528236
71DAPK10.32832758
72CSK0.32396978
73GRK50.31139506
74FGFR20.30765636
75PKN10.28830117
76MINK10.28451879
77OBSCN0.27703554
78PAK30.27391579
79KSR10.26849645
80DAPK30.26662962
81INSRR0.24971453
82NLK0.24656872
83MAPK70.23646013
84ADRBK10.23131211
85FGFR10.23076812
86MAP2K10.22526452
87MAPK130.22296994
88PAK20.21481749
89PRKCQ0.21361362
90STK160.20885305
91MAP4K20.20628997
92ERBB30.19637999
93FGR0.19392466
94GSK3A0.19276467
95STK38L0.17898000
96MAPK120.17540154
97RIPK10.17120632
98CDK90.16115661
99CCNB10.14732921
100PRKG10.14534777

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.05586466
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.53098981
3Protein export_Homo sapiens_hsa030602.48026536
4Nitrogen metabolism_Homo sapiens_hsa009102.36939386
5ECM-receptor interaction_Homo sapiens_hsa045122.16539556
6Leukocyte transendothelial migration_Homo sapiens_hsa046702.09484501
7Tight junction_Homo sapiens_hsa045302.01384226
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96806553
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91955411
10Focal adhesion_Homo sapiens_hsa045101.90191828
11Adherens junction_Homo sapiens_hsa045201.88850388
12Fatty acid elongation_Homo sapiens_hsa000621.88703499
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.86397465
14HIF-1 signaling pathway_Homo sapiens_hsa040661.80403930
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.62864602
16Rap1 signaling pathway_Homo sapiens_hsa040151.61287948
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59152263
18Complement and coagulation cascades_Homo sapiens_hsa046101.56607704
19Parkinsons disease_Homo sapiens_hsa050121.53649259
20Renin-angiotensin system_Homo sapiens_hsa046141.51285622
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50427099
22Sulfur metabolism_Homo sapiens_hsa009201.49047607
23Ras signaling pathway_Homo sapiens_hsa040141.48448340
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45836831
25Steroid biosynthesis_Homo sapiens_hsa001001.45717241
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45247802
27Sphingolipid metabolism_Homo sapiens_hsa006001.42493983
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41724766
29Oxidative phosphorylation_Homo sapiens_hsa001901.39930471
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34707286
31Glutathione metabolism_Homo sapiens_hsa004801.34481910
32Propanoate metabolism_Homo sapiens_hsa006401.28397217
33Caffeine metabolism_Homo sapiens_hsa002321.27033610
34Basal transcription factors_Homo sapiens_hsa030221.26141439
35Alzheimers disease_Homo sapiens_hsa050101.23861262
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18349157
37Vitamin digestion and absorption_Homo sapiens_hsa049771.17589181
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17075481
39ABC transporters_Homo sapiens_hsa020101.16686708
40Dorso-ventral axis formation_Homo sapiens_hsa043201.13908925
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12271217
42Phototransduction_Homo sapiens_hsa047441.10294920
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09690432
44Axon guidance_Homo sapiens_hsa043601.09509111
45Fatty acid degradation_Homo sapiens_hsa000711.07704971
46Selenocompound metabolism_Homo sapiens_hsa004501.04288874
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03539781
48Circadian rhythm_Homo sapiens_hsa047101.01893890
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99728185
50Retinol metabolism_Homo sapiens_hsa008300.98792315
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97642343
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96178069
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94309027
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.87892008
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86678445
56Tryptophan metabolism_Homo sapiens_hsa003800.84080835
57Chemical carcinogenesis_Homo sapiens_hsa052040.83300974
58Regulation of autophagy_Homo sapiens_hsa041400.82888758
59Dilated cardiomyopathy_Homo sapiens_hsa054140.82754665
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82665961
61Huntingtons disease_Homo sapiens_hsa050160.82141694
62TGF-beta signaling pathway_Homo sapiens_hsa043500.81525562
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78414720
64Fatty acid metabolism_Homo sapiens_hsa012120.76056467
65Pyruvate metabolism_Homo sapiens_hsa006200.74163655
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73568420
67Starch and sucrose metabolism_Homo sapiens_hsa005000.73162741
68Glycerolipid metabolism_Homo sapiens_hsa005610.71192193
69Histidine metabolism_Homo sapiens_hsa003400.70749454
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70670187
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69597709
72Arginine and proline metabolism_Homo sapiens_hsa003300.69337318
73beta-Alanine metabolism_Homo sapiens_hsa004100.67961428
74Bile secretion_Homo sapiens_hsa049760.67793710
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67198892
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65862925
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64259992
78Protein digestion and absorption_Homo sapiens_hsa049740.62809135
79Platelet activation_Homo sapiens_hsa046110.57863243
80Proteoglycans in cancer_Homo sapiens_hsa052050.54684308
81Hippo signaling pathway_Homo sapiens_hsa043900.52930796
82N-Glycan biosynthesis_Homo sapiens_hsa005100.49957772
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47700194
84African trypanosomiasis_Homo sapiens_hsa051430.46230677
85Galactose metabolism_Homo sapiens_hsa000520.44172847
86Morphine addiction_Homo sapiens_hsa050320.43774554
87Pathways in cancer_Homo sapiens_hsa052000.43495172
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43359811
89Vibrio cholerae infection_Homo sapiens_hsa051100.43125896
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42451494
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42154189
92PPAR signaling pathway_Homo sapiens_hsa033200.42042944
93Shigellosis_Homo sapiens_hsa051310.41041264
94Pancreatic secretion_Homo sapiens_hsa049720.40251223
95Prion diseases_Homo sapiens_hsa050200.40234245
96Linoleic acid metabolism_Homo sapiens_hsa005910.38471958
97Ovarian steroidogenesis_Homo sapiens_hsa049130.38319913
98Ether lipid metabolism_Homo sapiens_hsa005650.35659540
99Serotonergic synapse_Homo sapiens_hsa047260.34591108
100Small cell lung cancer_Homo sapiens_hsa052220.34187962

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