

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 7.52949680 |
| 2 | modulation by symbiont of host immune response (GO:0052553) | 7.52949680 |
| 3 | positive regulation by symbiont of host defense response (GO:0052509) | 7.52949680 |
| 4 | modulation by symbiont of host defense response (GO:0052031) | 7.52949680 |
| 5 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 7.52949680 |
| 6 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 7.52949680 |
| 7 | oligosaccharide catabolic process (GO:0009313) | 7.44482693 |
| 8 | glycolipid catabolic process (GO:0019377) | 6.39091641 |
| 9 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.95822232 |
| 10 | amino sugar catabolic process (GO:0046348) | 5.95050569 |
| 11 | ceramide catabolic process (GO:0046514) | 5.90382405 |
| 12 | regulation of interferon-beta biosynthetic process (GO:0045357) | 5.86537563 |
| 13 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 5.81784799 |
| 14 | neutrophil activation involved in immune response (GO:0002283) | 5.68372512 |
| 15 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 5.65172360 |
| 16 | macrophage activation involved in immune response (GO:0002281) | 5.28764028 |
| 17 | positive regulation of chemokine biosynthetic process (GO:0045080) | 5.28543543 |
| 18 | eosinophil chemotaxis (GO:0048245) | 5.14128974 |
| 19 | osteoclast differentiation (GO:0030316) | 5.03072087 |
| 20 | respiratory burst (GO:0045730) | 4.76089360 |
| 21 | regulation of monocyte differentiation (GO:0045655) | 4.61125310 |
| 22 | low-density lipoprotein particle clearance (GO:0034383) | 4.60057913 |
| 23 | glucosamine-containing compound catabolic process (GO:1901072) | 4.55897536 |
| 24 | eosinophil migration (GO:0072677) | 4.50199174 |
| 25 | granulocyte activation (GO:0036230) | 4.46735121 |
| 26 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.45738799 |
| 27 | response to host immune response (GO:0052572) | 4.45738799 |
| 28 | regulation of mononuclear cell migration (GO:0071675) | 4.45453555 |
| 29 | membrane lipid catabolic process (GO:0046466) | 4.43884745 |
| 30 | positive regulation of heat generation (GO:0031652) | 4.40200463 |
| 31 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 4.38697162 |
| 32 | sphingolipid catabolic process (GO:0030149) | 4.34525293 |
| 33 | negative regulation of interleukin-12 production (GO:0032695) | 4.33974348 |
| 34 | positive regulation of interferon-alpha production (GO:0032727) | 4.33894410 |
| 35 | positive regulation of monocyte chemotaxis (GO:0090026) | 4.29887624 |
| 36 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.25087973 |
| 37 | response to thyroid hormone (GO:0097066) | 4.23095583 |
| 38 | myeloid cell activation involved in immune response (GO:0002275) | 4.21297797 |
| 39 | regulation of interferon-alpha production (GO:0032647) | 4.13853890 |
| 40 | regulation of chemokine biosynthetic process (GO:0045073) | 4.13664211 |
| 41 | negative regulation of mast cell activation (GO:0033004) | 4.09656744 |
| 42 | regulation of vitamin D biosynthetic process (GO:0060556) | 4.08829579 |
| 43 | myeloid dendritic cell differentiation (GO:0043011) | 4.07156508 |
| 44 | ganglioside metabolic process (GO:0001573) | 4.03744848 |
| 45 | phagosome maturation (GO:0090382) | 4.02888055 |
| 46 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.99390486 |
| 47 | response to host (GO:0075136) | 3.99390486 |
| 48 | response to host defenses (GO:0052200) | 3.99390486 |
| 49 | monocyte chemotaxis (GO:0002548) | 3.97914837 |
| 50 | response to peptidoglycan (GO:0032494) | 3.97700720 |
| 51 | microglial cell activation (GO:0001774) | 3.97618962 |
| 52 | positive regulation of antigen processing and presentation (GO:0002579) | 3.92148838 |
| 53 | regulation of fever generation (GO:0031620) | 3.84069331 |
| 54 | macrophage activation (GO:0042116) | 3.83833681 |
| 55 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.82115768 |
| 56 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.81371318 |
| 57 | hydrogen peroxide biosynthetic process (GO:0050665) | 3.76336222 |
| 58 | positive regulation of osteoclast differentiation (GO:0045672) | 3.76236308 |
| 59 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.75047513 |
| 60 | positive regulation of macrophage derived foam cell differentiation (GO:0010744) | 3.66395087 |
| 61 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.65515502 |
| 62 | intracellular pH reduction (GO:0051452) | 3.65291822 |
| 63 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 3.63965155 |
| 64 | cellular extravasation (GO:0045123) | 3.62070599 |
| 65 | immunoglobulin mediated immune response (GO:0016064) | 3.60432035 |
| 66 | myeloid dendritic cell activation (GO:0001773) | 3.57082600 |
| 67 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 3.56844389 |
| 68 | positive regulation of tissue remodeling (GO:0034105) | 3.55788629 |
| 69 | positive regulation of macrophage cytokine production (GO:0060907) | 3.54952524 |
| 70 | N-acetylneuraminate metabolic process (GO:0006054) | 3.51265341 |
| 71 | phagocytosis, recognition (GO:0006910) | 3.50867638 |
| 72 | positive regulation of mast cell activation (GO:0033005) | 3.50030394 |
| 73 | positive regulation of cholesterol efflux (GO:0010875) | 3.49248712 |
| 74 | regulation of mast cell degranulation (GO:0043304) | 3.45979630 |
| 75 | detection of molecule of bacterial origin (GO:0032490) | 3.43070229 |
| 76 | positive regulation of leukocyte degranulation (GO:0043302) | 3.42615410 |
| 77 | regulation of cholesterol storage (GO:0010885) | 3.37975404 |
| 78 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.35317826 |
| 79 | macrophage chemotaxis (GO:0048246) | 3.34568558 |
| 80 | regulation of mast cell activation (GO:0033003) | 3.34488084 |
| 81 | vitamin D metabolic process (GO:0042359) | 3.34194851 |
| 82 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.33395434 |
| 83 | regulation of heat generation (GO:0031650) | 3.32128373 |
| 84 | regulation of macrophage derived foam cell differentiation (GO:0010743) | 3.31313800 |
| 85 | neutrophil activation (GO:0042119) | 3.31189964 |
| 86 | reactive oxygen species biosynthetic process (GO:1903409) | 3.29053412 |
| 87 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.28011375 |
| 88 | regulation of antigen processing and presentation (GO:0002577) | 3.26805627 |
| 89 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.22143344 |
| 90 | positive regulation of mast cell degranulation (GO:0043306) | 3.22143344 |
| 91 | plasma lipoprotein particle clearance (GO:0034381) | 3.17560960 |
| 92 | pH reduction (GO:0045851) | 3.17509343 |
| 93 | regulation of monocyte chemotaxis (GO:0090025) | 3.16521650 |
| 94 | decidualization (GO:0046697) | 3.16179856 |
| 95 | apoptotic cell clearance (GO:0043277) | 3.15947798 |
| 96 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.14814868 |
| 97 | transferrin transport (GO:0033572) | 3.14558399 |
| 98 | regulation of macrophage cytokine production (GO:0010935) | 3.12842327 |
| 99 | wound healing, spreading of epidermal cells (GO:0035313) | 3.11908962 |
| 100 | negative regulation of lipid storage (GO:0010888) | 3.09995036 |
| 101 | keratan sulfate catabolic process (GO:0042340) | 3.09552714 |
| 102 | cellular response to zinc ion (GO:0071294) | 3.09442854 |
| 103 | macrophage differentiation (GO:0030225) | 3.09277518 |
| 104 | regulation of vitamin metabolic process (GO:0030656) | 3.08168663 |
| 105 | pyrimidine-containing compound transmembrane transport (GO:0072531) | 3.06568574 |
| 106 | leukocyte degranulation (GO:0043299) | 3.06445036 |
| 107 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 3.05166061 |
| 108 | positive regulation of interferon-beta production (GO:0032728) | 3.03353483 |
| 109 | glycosphingolipid catabolic process (GO:0046479) | 3.02618390 |
| 110 | regulation of toll-like receptor 4 signaling pathway (GO:0034143) | 3.02209521 |
| 111 | natural killer cell mediated immunity (GO:0002228) | 3.02082274 |
| 112 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.02082274 |
| 113 | cellular response to arsenic-containing substance (GO:0071243) | 3.02075431 |
| 114 | dendritic cell differentiation (GO:0097028) | 3.01452206 |
| 115 | pinocytosis (GO:0006907) | 3.00570729 |
| 116 | positive regulation of sterol transport (GO:0032373) | 2.99526728 |
| 117 | positive regulation of cholesterol transport (GO:0032376) | 2.99526728 |
| 118 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.99502659 |
| 119 | superoxide anion generation (GO:0042554) | 2.99415426 |
| 120 | neutrophil mediated immunity (GO:0002446) | 2.98728278 |
| 121 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.95609281 |
| 122 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.95609281 |
| 123 | T-helper 1 type immune response (GO:0042088) | 2.95407527 |
| 124 | neutrophil chemotaxis (GO:0030593) | 2.94111679 |
| 125 | regulation of podosome assembly (GO:0071801) | 2.93548976 |
| 126 | myeloid cell homeostasis (GO:0002262) | 2.92518564 |
| 127 | myeloid leukocyte activation (GO:0002274) | 2.91989685 |
| 128 | defense response to protozoan (GO:0042832) | 2.91781251 |
| 129 | regulation of leukocyte degranulation (GO:0043300) | 2.91583987 |
| 130 | lymphocyte chemotaxis (GO:0048247) | 2.91133471 |
| 131 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.90997645 |
| 132 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 2.90835391 |
| 133 | response to lipoprotein particle (GO:0055094) | 2.90189708 |
| 134 | trivalent inorganic cation transport (GO:0072512) | 2.89194062 |
| 135 | ferric iron transport (GO:0015682) | 2.89194062 |
| 136 | positive regulation of lipid storage (GO:0010884) | 2.88490689 |
| 137 | regulation of lymphocyte chemotaxis (GO:1901623) | 2.88013680 |
| 138 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.87929028 |
| 139 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.87830134 |
| 140 | positive regulation of chemokine production (GO:0032722) | 2.86692344 |
| 141 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.86277949 |
| 142 | neutrophil migration (GO:1990266) | 2.85607683 |
| 143 | positive regulation of bone remodeling (GO:0046852) | 2.84500678 |
| 144 | positive regulation of bone resorption (GO:0045780) | 2.84500678 |
| 145 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 2.84302978 |
| 146 | response to muramyl dipeptide (GO:0032495) | 2.84185648 |
| 147 | positive regulation of lymphocyte migration (GO:2000403) | 2.83257946 |
| 148 | low-density lipoprotein particle remodeling (GO:0034374) | 2.83205417 |
| 149 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.82200813 |
| 150 | negative regulation of amino acid transport (GO:0051956) | 2.81509435 |
| 151 | negative regulation of response to reactive oxygen species (GO:1901032) | 2.81012419 |
| 152 | response to manganese ion (GO:0010042) | 2.79923635 |
| 153 | negative regulation of interleukin-1 beta production (GO:0032691) | 2.78929506 |
| 154 | negative regulation of hydrogen peroxide-induced cell death (GO:1903206) | 2.78096553 |
| 155 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.77040515 |
| 156 | regulation of bone resorption (GO:0045124) | 2.76141726 |
| 157 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 2.74308480 |
| 158 | iron ion import (GO:0097286) | 2.73512788 |
| 159 | lysosome organization (GO:0007040) | 2.71859855 |
| 160 | lytic vacuole organization (GO:0080171) | 2.71859855 |
| 161 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.71809005 |
| 162 | regulation of lipid storage (GO:0010883) | 2.70676453 |
| 163 | lipid storage (GO:0019915) | 2.70159408 |
| 164 | sphingosine metabolic process (GO:0006670) | 2.65433117 |
| 165 | protein localization to endosome (GO:0036010) | 2.64190985 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 8.40546231 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 6.66904367 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.70136844 |
| 4 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 4.82061624 |
| 5 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.40215070 |
| 6 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.28948281 |
| 7 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.71218766 |
| 8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.19684164 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.13652892 |
| 10 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.98793158 |
| 11 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.86854607 |
| 12 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.76696714 |
| 13 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.65009560 |
| 14 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.40401105 |
| 15 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 2.39180322 |
| 16 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.25821477 |
| 17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.20869437 |
| 18 | VDR_24787735_ChIP-Seq_THP-1_Human | 2.10392346 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.08809572 |
| 20 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.05275362 |
| 21 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.98845203 |
| 22 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.98728256 |
| 23 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.98246836 |
| 24 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.97061889 |
| 25 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.89348617 |
| 26 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.86591874 |
| 27 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.85916771 |
| 28 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.84927524 |
| 29 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.80987105 |
| 30 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.78307615 |
| 31 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.74419738 |
| 32 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.72221451 |
| 33 | SPI1_23127762_ChIP-Seq_K562_Human | 1.71718559 |
| 34 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70923295 |
| 35 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.67258233 |
| 36 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.65711704 |
| 37 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.61321093 |
| 38 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.58999325 |
| 39 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.58535930 |
| 40 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.53546288 |
| 41 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.49017656 |
| 42 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.47820262 |
| 43 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.46227750 |
| 44 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.42629968 |
| 45 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.42004332 |
| 46 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.36368004 |
| 47 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.33900390 |
| 48 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.27992415 |
| 49 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.27861410 |
| 50 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.27852484 |
| 51 | MYB_26560356_Chip-Seq_TH2_Human | 1.27171231 |
| 52 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25936569 |
| 53 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.25014583 |
| 54 | MAF_26560356_Chip-Seq_TH1_Human | 1.21678394 |
| 55 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.18662242 |
| 56 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.17272856 |
| 57 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.16809485 |
| 58 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.16809485 |
| 59 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.16369140 |
| 60 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.14951782 |
| 61 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.14443523 |
| 62 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.12174537 |
| 63 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.12171584 |
| 64 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.11087142 |
| 65 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.10630431 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.09544397 |
| 67 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.07044829 |
| 68 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.03842676 |
| 69 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.02734802 |
| 70 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.01327477 |
| 71 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.00308080 |
| 72 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98785182 |
| 73 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.98441672 |
| 74 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.97795984 |
| 75 | MYB_26560356_Chip-Seq_TH1_Human | 0.97399169 |
| 76 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.96819113 |
| 77 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.95999883 |
| 78 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.95373346 |
| 79 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.95330579 |
| 80 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.94412215 |
| 81 | UTX_26944678_Chip-Seq_JUKART_Human | 0.94410031 |
| 82 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.93360471 |
| 83 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.92130277 |
| 84 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.90973555 |
| 85 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90962152 |
| 86 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.90677931 |
| 87 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.90446546 |
| 88 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.90263487 |
| 89 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.89232817 |
| 90 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.88907095 |
| 91 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.88780592 |
| 92 | * GATA3_26560356_Chip-Seq_TH2_Human | 0.88678985 |
| 93 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.88575556 |
| 94 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88076106 |
| 95 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88045605 |
| 96 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.88032767 |
| 97 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.87659970 |
| 98 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.87330072 |
| 99 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.86769871 |
| 100 | CJUN_26792858_Chip-Seq_BT549_Human | 0.85758244 |
| 101 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.85751230 |
| 102 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.83360684 |
| 103 | GATA1_19941826_ChIP-Seq_K562_Human | 0.82872422 |
| 104 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.82384566 |
| 105 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.80363269 |
| 106 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.80026310 |
| 107 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.79328782 |
| 108 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.78536783 |
| 109 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.77986297 |
| 110 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.77615972 |
| 111 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.75941033 |
| 112 | GATA1_22025678_ChIP-Seq_K562_Human | 0.75925794 |
| 113 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.75145175 |
| 114 | GATA2_19941826_ChIP-Seq_K562_Human | 0.73385875 |
| 115 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.70622073 |
| 116 | * CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.69470869 |
| 117 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.69263283 |
| 118 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.68058922 |
| 119 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.64628664 |
| 120 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.63296141 |
| 121 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.62303060 |
| 122 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.62162972 |
| 123 | * EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.61558894 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006082_CNS_inflammation | 4.74677221 |
| 2 | MP0003303_peritoneal_inflammation | 4.60046047 |
| 3 | MP0005058_abnormal_lysosome_morphology | 4.55862437 |
| 4 | MP0003436_decreased_susceptibility_to | 4.14907086 |
| 5 | MP0002139_abnormal_hepatobiliary_system | 4.01596938 |
| 6 | MP0005257_abnormal_intraocular_pressure | 3.57169227 |
| 7 | MP0003172_abnormal_lysosome_physiology | 3.33360600 |
| 8 | MP0001835_abnormal_antigen_presentation | 3.18792773 |
| 9 | MP0002419_abnormal_innate_immunity | 3.14404607 |
| 10 | MP0009785_altered_susceptibility_to | 2.87712612 |
| 11 | MP0005000_abnormal_immune_tolerance | 2.67698712 |
| 12 | MP0003690_abnormal_glial_cell | 2.49427550 |
| 13 | MP0003329_amyloid_beta_deposits | 2.48521264 |
| 14 | MP0005025_abnormal_response_to | 2.45110353 |
| 15 | MP0002148_abnormal_hypersensitivity_rea | 2.40096892 |
| 16 | MP0009840_abnormal_foam_cell | 2.39323286 |
| 17 | MP0003191_abnormal_cellular_cholesterol | 2.35687984 |
| 18 | MP0003724_increased_susceptibility_to | 2.25058194 |
| 19 | MP0002452_abnormal_antigen_presenting | 2.24210286 |
| 20 | MP0005451_abnormal_body_composition | 2.20098697 |
| 21 | MP0001533_abnormal_skeleton_physiology | 2.19860251 |
| 22 | MP0003806_abnormal_nucleotide_metabolis | 2.15918546 |
| 23 | MP0004510_myositis | 2.13095113 |
| 24 | MP0002998_abnormal_bone_remodeling | 1.98393503 |
| 25 | MP0002723_abnormal_immune_serum | 1.95482938 |
| 26 | MP0002877_abnormal_melanocyte_morpholog | 1.88160485 |
| 27 | MP0000604_amyloidosis | 1.84393020 |
| 28 | MP0002405_respiratory_system_inflammati | 1.79822105 |
| 29 | MP0004947_skin_inflammation | 1.79250098 |
| 30 | MP0010386_abnormal_urinary_bladder | 1.78715998 |
| 31 | MP0001819_abnormal_immune_cell | 1.77526700 |
| 32 | MP0002420_abnormal_adaptive_immunity | 1.76850144 |
| 33 | MP0001790_abnormal_immune_system | 1.76645916 |
| 34 | MP0005387_immune_system_phenotype | 1.76645916 |
| 35 | MP0003448_altered_tumor_morphology | 1.73847548 |
| 36 | MP0003075_altered_response_to | 1.72158797 |
| 37 | MP0001800_abnormal_humoral_immune | 1.70931645 |
| 38 | MP0005167_abnormal_blood-brain_barrier | 1.70900893 |
| 39 | MP0005464_abnormal_platelet_physiology | 1.70807908 |
| 40 | MP0005365_abnormal_bile_salt | 1.67105689 |
| 41 | MP0002254_reproductive_system_inflammat | 1.64300063 |
| 42 | MP0009764_decreased_sensitivity_to | 1.61869476 |
| 43 | MP0001853_heart_inflammation | 1.61547498 |
| 44 | MP0000343_altered_response_to | 1.57776704 |
| 45 | MP0001845_abnormal_inflammatory_respons | 1.53540319 |
| 46 | MP0005166_decreased_susceptibility_to | 1.51162554 |
| 47 | MP0008469_abnormal_protein_level | 1.48408005 |
| 48 | MP0000858_altered_metastatic_potential | 1.46952010 |
| 49 | MP0005671_abnormal_response_to | 1.46077619 |
| 50 | MP0001851_eye_inflammation | 1.43659672 |
| 51 | MP0004130_abnormal_muscle_cell | 1.43328301 |
| 52 | MP0003300_gastrointestinal_ulcer | 1.41078124 |
| 53 | MP0000685_abnormal_immune_system | 1.39551852 |
| 54 | MP0003656_abnormal_erythrocyte_physiolo | 1.37661605 |
| 55 | MP0008438_abnormal_cutaneous_collagen | 1.37334652 |
| 56 | MP0000569_abnormal_digit_pigmentation | 1.36113691 |
| 57 | MP0003566_abnormal_cell_adhesion | 1.31466799 |
| 58 | MP0003705_abnormal_hypodermis_morpholog | 1.29269702 |
| 59 | MP0002090_abnormal_vision | 1.29030105 |
| 60 | MP0005647_abnormal_sex_gland | 1.25792123 |
| 61 | MP0000920_abnormal_myelination | 1.25669224 |
| 62 | MP0005310_abnormal_salivary_gland | 1.23831683 |
| 63 | MP0009333_abnormal_splenocyte_physiolog | 1.21472811 |
| 64 | MP0006054_spinal_hemorrhage | 1.19692618 |
| 65 | MP0001958_emphysema | 1.19063479 |
| 66 | MP0000716_abnormal_immune_system | 1.17564322 |
| 67 | MP0002837_dystrophic_cardiac_calcinosis | 1.15342395 |
| 68 | MP0002933_joint_inflammation | 1.14432219 |
| 69 | MP0005390_skeleton_phenotype | 1.10117032 |
| 70 | MP0004185_abnormal_adipocyte_glucose | 1.08721455 |
| 71 | MP0010307_abnormal_tumor_latency | 1.08172989 |
| 72 | MP0000689_abnormal_spleen_morphology | 1.06838955 |
| 73 | MP0003186_abnormal_redox_activity | 1.01681435 |
| 74 | MP0002006_tumorigenesis | 0.99513772 |
| 75 | MP0004019_abnormal_vitamin_homeostasis | 0.99050230 |
| 76 | MP0004883_abnormal_blood_vessel | 0.98502375 |
| 77 | MP0003632_abnormal_nervous_system | 0.97354877 |
| 78 | MP0005164_abnormal_response_to | 0.96072591 |
| 79 | MP0010155_abnormal_intestine_physiology | 0.95537160 |
| 80 | MP0008875_abnormal_xenobiotic_pharmacok | 0.94410247 |
| 81 | MP0002429_abnormal_blood_cell | 0.92272260 |
| 82 | MP0002398_abnormal_bone_marrow | 0.90740548 |
| 83 | MP0002722_abnormal_immune_system | 0.89847576 |
| 84 | MP0003828_pulmonary_edema | 0.89799602 |
| 85 | MP0003634_abnormal_glial_cell | 0.89699112 |
| 86 | MP0009278_abnormal_bone_marrow | 0.88662615 |
| 87 | MP0003279_aneurysm | 0.85146486 |
| 88 | MP0003795_abnormal_bone_structure | 0.82464427 |
| 89 | MP0005174_abnormal_tail_pigmentation | 0.78447474 |
| 90 | MP0000465_gastrointestinal_hemorrhage | 0.77533416 |
| 91 | MP0009763_increased_sensitivity_to | 0.77071664 |
| 92 | MP0010329_abnormal_lipoprotein_level | 0.75599936 |
| 93 | MP0003091_abnormal_cell_migration | 0.73132138 |
| 94 | MP0005410_abnormal_fertilization | 0.72984192 |
| 95 | MP0000015_abnormal_ear_pigmentation | 0.70322888 |
| 96 | MP0001727_abnormal_embryo_implantation | 0.69700502 |
| 97 | MP0003950_abnormal_plasma_membrane | 0.69598303 |
| 98 | MP0003646_muscle_fatigue | 0.68637369 |
| 99 | MP0005397_hematopoietic_system_phenotyp | 0.67794683 |
| 100 | MP0001545_abnormal_hematopoietic_system | 0.67794683 |
| 101 | MP0000249_abnormal_blood_vessel | 0.67194447 |
| 102 | MP0004742_abnormal_vestibular_system | 0.67126888 |
| 103 | MP0001501_abnormal_sleep_pattern | 0.67008072 |
| 104 | MP0003183_abnormal_peptide_metabolism | 0.66900088 |
| 105 | MP0005165_increased_susceptibility_to | 0.66605505 |
| 106 | MP0000371_diluted_coat_color | 0.66298451 |
| 107 | MP0003195_calcinosis | 0.66106545 |
| 108 | MP0010352_gastrointestinal_tract_polyps | 0.65693960 |
| 109 | MP0003633_abnormal_nervous_system | 0.65683041 |
| 110 | MP0005319_abnormal_enzyme/_coenzyme | 0.65571286 |
| 111 | MP0000609_abnormal_liver_physiology | 0.65391992 |
| 112 | MP0003631_nervous_system_phenotype | 0.64398866 |
| 113 | MP0005379_endocrine/exocrine_gland_phen | 0.62711979 |
| 114 | MP0001663_abnormal_digestive_system | 0.62125301 |
| 115 | MP0005595_abnormal_vascular_smooth | 0.62048220 |
| 116 | MP0002332_abnormal_exercise_endurance | 0.61675433 |
| 117 | MP0003453_abnormal_keratinocyte_physiol | 0.60812628 |
| 118 | MP0009115_abnormal_fat_cell | 0.59535423 |
| 119 | MP0000681_abnormal_thyroid_gland | 0.58671689 |
| 120 | MP0002136_abnormal_kidney_physiology | 0.58104066 |
| 121 | MP0005197_abnormal_uvea_morphology | 0.57946092 |
| 122 | MP0008004_abnormal_stomach_pH | 0.57695518 |
| 123 | MP0004808_abnormal_hematopoietic_stem | 0.57305405 |
| 124 | MP0008874_decreased_physiological_sensi | 0.54567598 |
| 125 | MP0004858_abnormal_nervous_system | 0.54501825 |
| 126 | MP0005076_abnormal_cell_differentiation | 0.54378280 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Increased cerebral lipofuscin (HP:0011813) | 7.97594702 |
| 2 | Recurrent gram-negative bacterial infections (HP:0005420) | 6.24420290 |
| 3 | Recurrent abscess formation (HP:0002722) | 6.23450209 |
| 4 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 6.14994270 |
| 5 | Vacuolated lymphocytes (HP:0001922) | 5.81798363 |
| 6 | Eczematoid dermatitis (HP:0000976) | 5.77397769 |
| 7 | Abnormality of macrophages (HP:0004311) | 5.40758586 |
| 8 | Recurrent bacterial skin infections (HP:0005406) | 5.38505587 |
| 9 | Abnormality of glycolipid metabolism (HP:0010969) | 5.22597829 |
| 10 | Abnormality of liposaccharide metabolism (HP:0010968) | 5.22597829 |
| 11 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 5.22597829 |
| 12 | Axonal loss (HP:0003447) | 4.95103211 |
| 13 | Dysostosis multiplex (HP:0000943) | 4.77544930 |
| 14 | Autoimmune thrombocytopenia (HP:0001973) | 4.37700421 |
| 15 | Loss of speech (HP:0002371) | 4.30486029 |
| 16 | Disinhibition (HP:0000734) | 4.30264873 |
| 17 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 4.23667051 |
| 18 | Urinary glycosaminoglycan excretion (HP:0003541) | 4.13901760 |
| 19 | Mucopolysacchariduria (HP:0008155) | 4.13901760 |
| 20 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 3.83683162 |
| 21 | Abnormality of polysaccharide metabolism (HP:0011012) | 3.83683162 |
| 22 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 3.83683162 |
| 23 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 3.82405889 |
| 24 | Chronic obstructive pulmonary disease (HP:0006510) | 3.64962242 |
| 25 | Obstructive lung disease (HP:0006536) | 3.64962242 |
| 26 | Mediastinal lymphadenopathy (HP:0100721) | 3.61835256 |
| 27 | Gingivitis (HP:0000230) | 3.54168229 |
| 28 | Myocardial infarction (HP:0001658) | 3.34183793 |
| 29 | Systemic lupus erythematosus (HP:0002725) | 3.28061244 |
| 30 | Hepatosplenomegaly (HP:0001433) | 3.25740232 |
| 31 | Metaphyseal irregularity (HP:0003025) | 3.25278068 |
| 32 | J-shaped sella turcica (HP:0002680) | 3.24174558 |
| 33 | Recurrent skin infections (HP:0001581) | 3.22453452 |
| 34 | Upper motor neuron abnormality (HP:0002127) | 3.20333975 |
| 35 | Global brain atrophy (HP:0002283) | 3.15618950 |
| 36 | Agnosia (HP:0010524) | 3.12248435 |
| 37 | Nausea (HP:0002018) | 3.05717044 |
| 38 | Peripheral demyelination (HP:0011096) | 2.99969303 |
| 39 | Nuclear cataract (HP:0100018) | 2.89903114 |
| 40 | Prostate neoplasm (HP:0100787) | 2.81977415 |
| 41 | Stomatitis (HP:0010280) | 2.79687452 |
| 42 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.75131728 |
| 43 | Asymmetric septal hypertrophy (HP:0001670) | 2.71889800 |
| 44 | Xanthomatosis (HP:0000991) | 2.71222363 |
| 45 | Neuronal loss in central nervous system (HP:0002529) | 2.70297138 |
| 46 | Conjunctival telangiectasia (HP:0000524) | 2.68477290 |
| 47 | Increased CSF protein (HP:0002922) | 2.67771102 |
| 48 | Tetraparesis (HP:0002273) | 2.65056077 |
| 49 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.64745906 |
| 50 | Abnormality of the lumbar spine (HP:0100712) | 2.56747520 |
| 51 | Recurrent fungal infections (HP:0002841) | 2.56171681 |
| 52 | Myositis (HP:0100614) | 2.53836836 |
| 53 | Esophageal neoplasm (HP:0100751) | 2.50834227 |
| 54 | Neoplasm of head and neck (HP:0012288) | 2.50834227 |
| 55 | Urticaria (HP:0001025) | 2.48956488 |
| 56 | Interstitial pulmonary disease (HP:0006530) | 2.46311955 |
| 57 | Basal ganglia calcification (HP:0002135) | 2.39251921 |
| 58 | Supranuclear gaze palsy (HP:0000605) | 2.39056463 |
| 59 | Generalized aminoaciduria (HP:0002909) | 2.36839847 |
| 60 | Protuberant abdomen (HP:0001538) | 2.35142660 |
| 61 | Increased serum ferritin (HP:0003281) | 2.34334786 |
| 62 | Multiple enchondromatosis (HP:0005701) | 2.32134153 |
| 63 | Poor head control (HP:0002421) | 2.30684341 |
| 64 | Orchitis (HP:0100796) | 2.30611664 |
| 65 | Dementia (HP:0000726) | 2.30111732 |
| 66 | Cellulitis (HP:0100658) | 2.28196054 |
| 67 | Pathologic fracture (HP:0002756) | 2.26441842 |
| 68 | Epidermoid cyst (HP:0200040) | 2.24790523 |
| 69 | Skin nodule (HP:0200036) | 2.20644663 |
| 70 | Abnormality of the periventricular white matter (HP:0002518) | 2.20561270 |
| 71 | Petechiae (HP:0000967) | 2.20440594 |
| 72 | Inappropriate behavior (HP:0000719) | 2.17283572 |
| 73 | Diminished motivation (HP:0000745) | 2.16229019 |
| 74 | Neurofibrillary tangles (HP:0002185) | 2.14193445 |
| 75 | Retinal atrophy (HP:0001105) | 2.13433576 |
| 76 | Periodontitis (HP:0000704) | 2.12952874 |
| 77 | Prolonged neonatal jaundice (HP:0006579) | 2.10874951 |
| 78 | Deformed sella turcica (HP:0002681) | 2.10781185 |
| 79 | Osteomyelitis (HP:0002754) | 2.10753643 |
| 80 | T lymphocytopenia (HP:0005403) | 2.10642995 |
| 81 | Apathy (HP:0000741) | 2.09285307 |
| 82 | Vasculitis (HP:0002633) | 2.09231766 |
| 83 | Thoracic kyphosis (HP:0002942) | 2.07802214 |
| 84 | Bone pain (HP:0002653) | 2.07650431 |
| 85 | Joint hemorrhage (HP:0005261) | 2.07454910 |
| 86 | Cardiomegaly (HP:0001640) | 2.04156489 |
| 87 | Purpura (HP:0000979) | 2.02366765 |
| 88 | Personality changes (HP:0000751) | 2.01664778 |
| 89 | Mucosal telangiectasiae (HP:0100579) | 1.99738678 |
| 90 | Clumsiness (HP:0002312) | 1.98625971 |
| 91 | Optic neuritis (HP:0100653) | 1.98589787 |
| 92 | Retrobulbar optic neuritis (HP:0100654) | 1.98589787 |
| 93 | Mutism (HP:0002300) | 1.97253896 |
| 94 | Paralysis (HP:0003470) | 1.97089274 |
| 95 | Vertebral compression fractures (HP:0002953) | 1.96489625 |
| 96 | Hematochezia (HP:0002573) | 1.95716132 |
| 97 | Spondylolisthesis (HP:0003302) | 1.94094317 |
| 98 | Ovoid vertebral bodies (HP:0003300) | 1.93657719 |
| 99 | Osteolytic defects of the hand bones (HP:0009699) | 1.91612332 |
| 100 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.91612332 |
| 101 | Glomerulonephritis (HP:0000099) | 1.91518051 |
| 102 | Hypercholesterolemia (HP:0003124) | 1.91235687 |
| 103 | Recurrent viral infections (HP:0004429) | 1.89869119 |
| 104 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.88062824 |
| 105 | Recurrent cutaneous fungal infections (HP:0011370) | 1.88062824 |
| 106 | Pustule (HP:0200039) | 1.85164809 |
| 107 | Abnormality of the prostate (HP:0008775) | 1.84735878 |
| 108 | Bone cyst (HP:0012062) | 1.84364185 |
| 109 | Cortical dysplasia (HP:0002539) | 1.84094129 |
| 110 | Spastic tetraparesis (HP:0001285) | 1.84000095 |
| 111 | Abnormality of iron homeostasis (HP:0011031) | 1.83409937 |
| 112 | Polyneuropathy (HP:0001271) | 1.80547362 |
| 113 | Abnormality of T cell number (HP:0011839) | 1.80207265 |
| 114 | Gingival bleeding (HP:0000225) | 1.80110538 |
| 115 | Esophageal varix (HP:0002040) | 1.79293278 |
| 116 | Progressive visual loss (HP:0000529) | 1.78196075 |
| 117 | Amaurosis fugax (HP:0100576) | 1.76452874 |
| 118 | Progressive neurologic deterioration (HP:0002344) | 1.75190233 |
| 119 | Cerebral inclusion bodies (HP:0100314) | 1.72145236 |
| 120 | Nephritis (HP:0000123) | 1.70580091 |
| 121 | Pulmonary infiltrates (HP:0002113) | 1.69946194 |
| 122 | Emphysema (HP:0002097) | 1.68340793 |
| 123 | Hypokinesia (HP:0002375) | 1.67725735 |
| 124 | Mesangial abnormality (HP:0001966) | 1.63241052 |
| 125 | Albinism (HP:0001022) | 1.62814739 |
| 126 | Multiple lipomas (HP:0001012) | 1.62576016 |
| 127 | Flat occiput (HP:0005469) | 1.59855455 |
| 128 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.59743773 |
| 129 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.59468296 |
| 130 | Combined immunodeficiency (HP:0005387) | 1.54605189 |
| 131 | Premature loss of primary teeth (HP:0006323) | 1.54061938 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERN1 | 4.87491885 |
| 2 | PBK | 4.32878745 |
| 3 | RIPK4 | 4.20644177 |
| 4 | TBK1 | 3.83768441 |
| 5 | ACVR1B | 3.45580720 |
| 6 | KIT | 2.71602898 |
| 7 | ADRBK2 | 2.66571710 |
| 8 | BLK | 2.48362040 |
| 9 | MUSK | 2.38999175 |
| 10 | DDR2 | 2.34667717 |
| 11 | ABL2 | 2.31394474 |
| 12 | IRAK3 | 2.29773730 |
| 13 | TRIB3 | 2.27501334 |
| 14 | IKBKB | 2.14764689 |
| 15 | TYK2 | 2.13180423 |
| 16 | TAOK2 | 2.05051722 |
| 17 | NME2 | 2.04402090 |
| 18 | MAP4K1 | 2.00268313 |
| 19 | SCYL2 | 1.99322521 |
| 20 | MAP3K14 | 1.89207353 |
| 21 | CDK12 | 1.62069842 |
| 22 | IRAK4 | 1.61719885 |
| 23 | BMX | 1.61229857 |
| 24 | TTN | 1.55633230 |
| 25 | HCK | 1.55562872 |
| 26 | FES | 1.51257697 |
| 27 | LIMK1 | 1.43547062 |
| 28 | MST1R | 1.42664869 |
| 29 | PKN2 | 1.40809726 |
| 30 | CSK | 1.40707035 |
| 31 | IKBKE | 1.39992154 |
| 32 | SYK | 1.38024009 |
| 33 | TAOK3 | 1.27828654 |
| 34 | CSF1R | 1.23375231 |
| 35 | MARK3 | 1.21833002 |
| 36 | PDK2 | 1.20957029 |
| 37 | TGFBR2 | 1.19798000 |
| 38 | ZAP70 | 1.18002184 |
| 39 | FGR | 1.13541522 |
| 40 | CDC42BPA | 1.11160157 |
| 41 | LYN | 1.11131938 |
| 42 | BTK | 1.10727959 |
| 43 | TESK2 | 1.08990981 |
| 44 | JAK1 | 1.07689960 |
| 45 | JAK2 | 1.07464756 |
| 46 | PTK6 | 1.07157726 |
| 47 | MAP2K6 | 1.05945416 |
| 48 | JAK3 | 1.05240110 |
| 49 | LRRK2 | 1.03323988 |
| 50 | LCK | 1.02589192 |
| 51 | PRKCH | 1.02211526 |
| 52 | MAP2K3 | 0.99816172 |
| 53 | RPS6KA4 | 0.96273071 |
| 54 | STK4 | 0.95057744 |
| 55 | PIM2 | 0.94849643 |
| 56 | SIK2 | 0.92047009 |
| 57 | ERBB4 | 0.89725035 |
| 58 | CHUK | 0.87064098 |
| 59 | STK10 | 0.85474527 |
| 60 | EGFR | 0.83913933 |
| 61 | RIPK1 | 0.83872157 |
| 62 | ABL1 | 0.82822077 |
| 63 | MATK | 0.80226200 |
| 64 | EPHB1 | 0.80214736 |
| 65 | MAP3K11 | 0.78707678 |
| 66 | NEK9 | 0.78228249 |
| 67 | MAP3K3 | 0.73955541 |
| 68 | MAP3K13 | 0.73815938 |
| 69 | PDPK1 | 0.73428508 |
| 70 | IRAK2 | 0.70366811 |
| 71 | ARAF | 0.68934891 |
| 72 | PRKCD | 0.67983065 |
| 73 | PDK1 | 0.67378495 |
| 74 | PIM1 | 0.66845304 |
| 75 | BMPR2 | 0.66023433 |
| 76 | TESK1 | 0.65262306 |
| 77 | TXK | 0.64588878 |
| 78 | RPS6KL1 | 0.64553159 |
| 79 | RPS6KC1 | 0.64553159 |
| 80 | FYN | 0.60692960 |
| 81 | MOS | 0.60169600 |
| 82 | MAP3K1 | 0.60080025 |
| 83 | KSR2 | 0.59739661 |
| 84 | CDK6 | 0.58036911 |
| 85 | TRPM7 | 0.57214359 |
| 86 | TEC | 0.55955739 |
| 87 | ITK | 0.53737128 |
| 88 | CLK1 | 0.53725960 |
| 89 | EIF2AK1 | 0.53371862 |
| 90 | PDGFRB | 0.52214358 |
| 91 | CAMK1G | 0.50818837 |
| 92 | MAPK12 | 0.50319022 |
| 93 | CAMK1D | 0.48470078 |
| 94 | CAMKK1 | 0.47464096 |
| 95 | EIF2AK3 | 0.46985826 |
| 96 | PAK4 | 0.46678235 |
| 97 | YES1 | 0.46244652 |
| 98 | DAPK3 | 0.44448243 |
| 99 | GRK7 | 0.43130723 |
| 100 | MAPK4 | 0.43121615 |
| 101 | GRK6 | 0.42412014 |
| 102 | CSNK1G3 | 0.41905038 |
| 103 | DAPK2 | 0.41631628 |
| 104 | CSNK1G2 | 0.41391148 |
| 105 | PRKG2 | 0.40876866 |
| 106 | ERBB3 | 0.40481603 |
| 107 | TAOK1 | 0.39440621 |
| 108 | CSNK1A1L | 0.38960255 |
| 109 | MAP3K8 | 0.38885530 |
| 110 | MAP3K9 | 0.38620663 |
| 111 | CAMK4 | 0.37437644 |
| 112 | PRPF4B | 0.37092629 |
| 113 | PIK3CG | 0.36003828 |
| 114 | SRC | 0.35951271 |
| 115 | IGF1R | 0.34878937 |
| 116 | CAMKK2 | 0.34695064 |
| 117 | ALK | 0.34486069 |
| 118 | INSR | 0.33479804 |
| 119 | MAP3K5 | 0.32983793 |
| 120 | KSR1 | 0.32380408 |
| 121 | BCKDK | 0.31408915 |
| 122 | RPS6KA2 | 0.30994359 |
| 123 | IRAK1 | 0.29606212 |
| 124 | PINK1 | 0.29568200 |
| 125 | CDK9 | 0.29254505 |
| 126 | GSK3A | 0.29042066 |
| 127 | TYRO3 | 0.29031305 |
| 128 | PRKCQ | 0.27908417 |
| 129 | RPS6KA1 | 0.27521941 |
| 130 | RPS6KA6 | 0.26671951 |
| 131 | MAP3K2 | 0.25386858 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Lysosome_Homo sapiens_hsa04142 | 4.08573555 |
| 2 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 3.47821206 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 3.38096767 |
| 4 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 3.27155108 |
| 5 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.75524946 |
| 6 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.72105296 |
| 7 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.67317702 |
| 8 | Phagosome_Homo sapiens_hsa04145 | 2.63783974 |
| 9 | Tuberculosis_Homo sapiens_hsa05152 | 2.57482343 |
| 10 | Legionellosis_Homo sapiens_hsa05134 | 2.44237371 |
| 11 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.38563585 |
| 12 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.32804254 |
| 13 | Malaria_Homo sapiens_hsa05144 | 2.31533250 |
| 14 | Pertussis_Homo sapiens_hsa05133 | 2.24228157 |
| 15 | Salmonella infection_Homo sapiens_hsa05132 | 2.05267472 |
| 16 | Other glycan degradation_Homo sapiens_hsa00511 | 1.96002178 |
| 17 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.91421233 |
| 18 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.90443298 |
| 19 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.79584275 |
| 20 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.79566001 |
| 21 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.53252345 |
| 22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.50226634 |
| 23 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.49974300 |
| 24 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.48527099 |
| 25 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.47071169 |
| 26 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.43948671 |
| 27 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.39173192 |
| 28 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.33884452 |
| 29 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.32477517 |
| 30 | Allograft rejection_Homo sapiens_hsa05330 | 1.24863472 |
| 31 | Measles_Homo sapiens_hsa05162 | 1.24568324 |
| 32 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.24224118 |
| 33 | Apoptosis_Homo sapiens_hsa04210 | 1.23660671 |
| 34 | Asthma_Homo sapiens_hsa05310 | 1.22442495 |
| 35 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.19546312 |
| 36 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.19309478 |
| 37 | Influenza A_Homo sapiens_hsa05164 | 1.17317542 |
| 38 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.13748813 |
| 39 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.11187470 |
| 40 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.10087888 |
| 41 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.09847736 |
| 42 | Mineral absorption_Homo sapiens_hsa04978 | 1.08034554 |
| 43 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.05953660 |
| 44 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.05931035 |
| 45 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.04247136 |
| 46 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.01990918 |
| 47 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.00836686 |
| 48 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.99928822 |
| 49 | Amoebiasis_Homo sapiens_hsa05146 | 0.99119865 |
| 50 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.98945658 |
| 51 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.89664556 |
| 52 | Shigellosis_Homo sapiens_hsa05131 | 0.88390415 |
| 53 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.87885489 |
| 54 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.83573389 |
| 55 | Prion diseases_Homo sapiens_hsa05020 | 0.81134028 |
| 56 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.80591980 |
| 57 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.78758043 |
| 58 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.71610036 |
| 59 | Bladder cancer_Homo sapiens_hsa05219 | 0.70997854 |
| 60 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.70967986 |
| 61 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.69874418 |
| 62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.69509544 |
| 63 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68532238 |
| 64 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.67461596 |
| 65 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.65977256 |
| 66 | Hepatitis B_Homo sapiens_hsa05161 | 0.63565039 |
| 67 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.62511067 |
| 68 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.58944474 |
| 69 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.58291633 |
| 70 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.56733735 |
| 71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.56142481 |
| 72 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.56117794 |
| 73 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.53436689 |
| 74 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.53251632 |
| 75 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.50817826 |
| 76 | Hepatitis C_Homo sapiens_hsa05160 | 0.50301283 |
| 77 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.49513401 |
| 78 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.47903790 |
| 79 | Platelet activation_Homo sapiens_hsa04611 | 0.47876613 |
| 80 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.47433435 |
| 81 | Galactose metabolism_Homo sapiens_hsa00052 | 0.47343819 |
| 82 | Endocytosis_Homo sapiens_hsa04144 | 0.47129672 |
| 83 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.46971452 |
| 84 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.44437314 |
| 85 | Viral myocarditis_Homo sapiens_hsa05416 | 0.43218214 |
| 86 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.43003532 |
| 87 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.42166020 |
| 88 | Insulin resistance_Homo sapiens_hsa04931 | 0.41873838 |
| 89 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.41502186 |
| 90 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.39582315 |
| 91 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.39281667 |
| 92 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.38753451 |
| 93 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.38717877 |
| 94 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38101449 |
| 95 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.37345071 |
| 96 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.37277366 |
| 97 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.33522138 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.31611347 |
| 99 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.30875119 |
| 100 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.29774447 |
| 101 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.27333368 |
| 102 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.26942952 |
| 103 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.26214674 |
| 104 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.25149290 |
| 105 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.24506833 |
| 106 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.24334622 |
| 107 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.23927108 |
| 108 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.23250845 |
| 109 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.21440598 |
| 110 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.16218204 |
| 111 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.14841950 |
| 112 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.14228877 |
| 113 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.13764481 |
| 114 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.11797896 |
| 115 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.09703440 |
| 116 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.07084499 |
| 117 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.04910897 |

