TM4SF19-TCTEX1D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)8.12006392
2oligosaccharide catabolic process (GO:0009313)6.40573324
3glycosphingolipid catabolic process (GO:0046479)6.22353038
4regulation of syncytium formation by plasma membrane fusion (GO:0060142)5.81052436
5glycolipid catabolic process (GO:0019377)5.58878236
6amino sugar catabolic process (GO:0046348)5.33445504
7ceramide catabolic process (GO:0046514)4.97854303
8cellular response to thyroid hormone stimulus (GO:0097067)4.72563561
9regulation of mononuclear cell migration (GO:0071675)4.68284416
10eosinophil chemotaxis (GO:0048245)4.62549527
11regulation of vitamin D biosynthetic process (GO:0060556)4.57711423
12osteoclast differentiation (GO:0030316)4.54734900
13regulation of monocyte differentiation (GO:0045655)4.54478838
14negative regulation of interleukin-12 production (GO:0032695)4.53588002
15regulation of cholesterol storage (GO:0010885)4.52405512
16response to peptidoglycan (GO:0032494)4.27201157
17myeloid dendritic cell differentiation (GO:0043011)4.21960159
18lipopolysaccharide-mediated signaling pathway (GO:0031663)4.16677425
19eosinophil migration (GO:0072677)4.10406957
20monocyte chemotaxis (GO:0002548)4.00180041
21negative regulation of nitric oxide biosynthetic process (GO:0045019)3.96655144
22neutrophil activation involved in immune response (GO:0002283)3.92276603
23response to thyroid hormone (GO:0097066)3.91952097
24membrane lipid catabolic process (GO:0046466)3.88907420
25sphingolipid catabolic process (GO:0030149)3.85574112
26N-acetylneuraminate metabolic process (GO:0006054)3.84319980
27glucosamine-containing compound catabolic process (GO:1901072)3.83722586
28myeloid dendritic cell activation (GO:0001773)3.74856878
29positive regulation of bone remodeling (GO:0046852)3.68626305
30positive regulation of bone resorption (GO:0045780)3.68626305
31regulation of vitamin metabolic process (GO:0030656)3.59760910
32positive regulation of osteoclast differentiation (GO:0045672)3.57450682
33positive regulation of monocyte chemotaxis (GO:0090026)3.49294101
34positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.46888630
35regulation of podosome assembly (GO:0071801)3.46637505
36fat-soluble vitamin biosynthetic process (GO:0042362)3.40940379
37decidualization (GO:0046697)3.36986538
38regulation of lymphocyte chemotaxis (GO:1901623)3.33399551
39positive regulation of chemokine biosynthetic process (GO:0045080)3.22442554
40cellular extravasation (GO:0045123)3.18798193
41dendritic cell differentiation (GO:0097028)3.17947983
42NIK/NF-kappaB signaling (GO:0038061)3.17779885
43macrophage differentiation (GO:0030225)3.15629732
44macrophage activation involved in immune response (GO:0002281)3.10643232
45positive regulation of tissue remodeling (GO:0034105)3.10523199
46regulation of membrane protein ectodomain proteolysis (GO:0051043)3.10411046
47positive regulation of leukocyte degranulation (GO:0043302)3.08627553
48negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.08060082
49ganglioside metabolic process (GO:0001573)3.07493922
50cellular response to arsenic-containing substance (GO:0071243)3.06917608
51phagosome maturation (GO:0090382)3.06824627
52positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05475520
53regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.05156997
54granulocyte activation (GO:0036230)3.04452979
55negative regulation of myeloid cell apoptotic process (GO:0033033)3.01080965
56positive regulation of mast cell activation (GO:0033005)2.99798492
57immunoglobulin mediated immune response (GO:0016064)2.98825263
58negative regulation of lipid storage (GO:0010888)2.97814058
59positive regulation of heat generation (GO:0031652)2.96142994
60T-helper 1 type immune response (GO:0042088)2.95907181
61barbed-end actin filament capping (GO:0051016)2.95887735
62germinal center formation (GO:0002467)2.95612478
63regulation of mast cell degranulation (GO:0043304)2.91249199
64regulation of macrophage chemotaxis (GO:0010758)2.90242854
65regulation of cytokine secretion involved in immune response (GO:0002739)2.89586447
66positive regulation of gamma-delta T cell activation (GO:0046645)2.86444961
67cellular response to lipopolysaccharide (GO:0071222)2.84135098
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.80217651
69positive regulation of mast cell degranulation (GO:0043306)2.80217651
70regulation of fever generation (GO:0031620)2.78641198
71regulation of chronic inflammatory response (GO:0002676)2.78487223
72cellular response to molecule of bacterial origin (GO:0071219)2.75866835
73regulation of chemokine biosynthetic process (GO:0045073)2.73890785
74response to protozoan (GO:0001562)2.73643433
75regulation of lymphocyte migration (GO:2000401)2.73377044
76pinocytosis (GO:0006907)2.72121057
77keratan sulfate catabolic process (GO:0042340)2.71562344
78detection of molecule of bacterial origin (GO:0032490)2.70230219
79positive regulation of interleukin-6 production (GO:0032755)2.69444438
80regulation of superoxide anion generation (GO:0032928)2.68906216
81positive regulation of cholesterol efflux (GO:0010875)2.68656007
82protein localization to endosome (GO:0036010)2.68042165
83regulation of monocyte chemotaxis (GO:0090025)2.67955389
84vitamin D metabolic process (GO:0042359)2.66667109
85regulation of mast cell activation involved in immune response (GO:0033006)2.66419394
86positive regulation of cellular amide metabolic process (GO:0034250)2.64992582
87intracellular pH reduction (GO:0051452)2.63651134
88positive regulation of macrophage differentiation (GO:0045651)2.63218183
89positive regulation of lymphocyte migration (GO:2000403)2.63046252
90transferrin transport (GO:0033572)2.62872085
91regulation of T-helper 1 cell differentiation (GO:0045625)2.62377506
92regulation of mast cell activation (GO:0033003)2.61706102
93regulation of leukocyte degranulation (GO:0043300)2.61213917
94myeloid cell activation involved in immune response (GO:0002275)2.60639513
95apoptotic cell clearance (GO:0043277)2.59884331
96positive regulation of NF-kappaB import into nucleus (GO:0042346)2.59841782
97granulocyte chemotaxis (GO:0071621)2.58199649
98regulation of nitric oxide biosynthetic process (GO:0045428)2.57618834
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57275447
100interferon-gamma-mediated signaling pathway (GO:0060333)2.56874826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.89446475
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.78991713
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.66289244
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.19734516
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.89511777
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.61488107
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.49222042
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41676875
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.13411345
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.98580577
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86440073
12VDR_24787735_ChIP-Seq_THP-1_Human2.37957559
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34869776
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27387177
15BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21707088
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19097713
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18327480
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17839950
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15978278
20SPI1_23547873_ChIP-Seq_NB4_Human2.15850460
21SPI1_23127762_ChIP-Seq_K562_Human2.13480889
22VDR_24763502_ChIP-Seq_THP-1_Human2.01986642
23VDR_21846776_ChIP-Seq_THP-1_Human2.00631108
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00058855
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.96690375
26SCL_19346495_ChIP-Seq_HPC-7_Human1.84477962
27GATA1_22025678_ChIP-Seq_K562_Human1.81256043
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80114201
29TFEB_21752829_ChIP-Seq_HELA_Human1.77586136
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77546253
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72405129
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72075692
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.68004327
34CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67674677
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.65086917
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65023897
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64186075
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62014183
39LXR_22292898_ChIP-Seq_THP-1_Human1.56860813
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56485609
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55971967
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54493252
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51392962
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50952844
45PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47974212
46PU_27001747_Chip-Seq_BMDM_Mouse1.45591737
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43912386
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43623180
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.40826912
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34838574
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34447749
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33843930
53SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33824885
54MAF_26560356_Chip-Seq_TH1_Human1.33597273
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31267740
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28696148
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27851468
58GATA1_19941826_ChIP-Seq_K562_Human1.26852682
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25793657
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24590841
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21812318
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20057877
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16238617
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15959285
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.15472263
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13894274
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13605912
68MYB_26560356_Chip-Seq_TH2_Human1.10996797
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.10641548
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08989414
71BCL6_27268052_Chip-Seq_Bcells_Human1.07254598
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04008402
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03648504
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03213771
75STAT1_20625510_ChIP-Seq_HELA_Human1.01370727
76GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98041328
77ELF1_20517297_ChIP-Seq_JURKAT_Human0.97480317
78UTX_26944678_Chip-Seq_JUKART_Human0.97373766
79NCOR1_26117541_ChIP-Seq_K562_Human0.97020179
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96875416
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96126375
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96071998
83BCOR_27268052_Chip-Seq_Bcells_Human0.95966635
84RUNX_20019798_ChIP-Seq_JUKART_Human0.93827060
85MAF_26560356_Chip-Seq_TH2_Human0.93506312
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93284038
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92132115
88RXR_22158963_ChIP-Seq_LIVER_Mouse0.92131483
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.91500698
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90608607
91KDM2B_26808549_Chip-Seq_DND41_Human0.90132852
92TCF7_22412390_ChIP-Seq_EML_Mouse0.88624640
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88264120
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85620815
95MYC_22102868_ChIP-Seq_BL_Human0.85501457
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.84235283
97GATA2_19941826_ChIP-Seq_K562_Human0.83721729
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.82340782
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81415820
100GATA3_26560356_Chip-Seq_TH2_Human0.80736284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.63929711
2MP0009840_abnormal_foam_cell4.05854167
3MP0003303_peritoneal_inflammation3.73347631
4MP0002139_abnormal_hepatobiliary_system3.58897388
5MP0006082_CNS_inflammation3.32193098
6MP0002148_abnormal_hypersensitivity_rea3.11379931
7MP0000604_amyloidosis3.09258758
8MP0003191_abnormal_cellular_cholesterol3.06898114
9MP0003172_abnormal_lysosome_physiology3.00187224
10MP0003436_decreased_susceptibility_to2.93340203
11MP0000343_altered_response_to2.66335143
12MP0002419_abnormal_innate_immunity2.56250898
13MP0003806_abnormal_nucleotide_metabolis2.55777282
14MP0009785_altered_susceptibility_to2.54849945
15MP0004510_myositis2.54352936
16MP0003724_increased_susceptibility_to2.39270409
17MP0005451_abnormal_body_composition2.35099759
18MP0005671_abnormal_response_to2.27930898
19MP0005000_abnormal_immune_tolerance2.18747972
20MP0009278_abnormal_bone_marrow2.16697866
21MP0001835_abnormal_antigen_presentation2.11923159
22MP0001853_heart_inflammation2.10980615
23MP0003075_altered_response_to2.08716932
24MP0009764_decreased_sensitivity_to2.07332428
25MP0005025_abnormal_response_to2.05128019
26MP0003329_amyloid_beta_deposits2.01609778
27MP0003300_gastrointestinal_ulcer2.01021447
28MP0005397_hematopoietic_system_phenotyp1.93351981
29MP0001545_abnormal_hematopoietic_system1.93351981
30MP0001790_abnormal_immune_system1.91486828
31MP0005387_immune_system_phenotype1.91486828
32MP0002998_abnormal_bone_remodeling1.90618177
33MP0002452_abnormal_antigen_presenting1.87134152
34MP0005167_abnormal_blood-brain_barrier1.83252921
35MP0001533_abnormal_skeleton_physiology1.81537333
36MP0002877_abnormal_melanocyte_morpholog1.72373187
37MP0002723_abnormal_immune_serum1.68662024
38MP0003195_calcinosis1.62337693
39MP0003656_abnormal_erythrocyte_physiolo1.62223088
40MP0001845_abnormal_inflammatory_respons1.59996832
41MP0003453_abnormal_keratinocyte_physiol1.59427656
42MP0005464_abnormal_platelet_physiology1.58075154
43MP0003690_abnormal_glial_cell1.51084679
44MP0004947_skin_inflammation1.51036064
45MP0008004_abnormal_stomach_pH1.50852387
46MP0009333_abnormal_splenocyte_physiolog1.46846138
47MP0002405_respiratory_system_inflammati1.46046851
48MP0002420_abnormal_adaptive_immunity1.45609152
49MP0008469_abnormal_protein_level1.44184902
50MP0001819_abnormal_immune_cell1.44090213
51MP0005310_abnormal_salivary_gland1.43732130
52MP0001800_abnormal_humoral_immune1.40489303
53MP0006054_spinal_hemorrhage1.39334641
54MP0003448_altered_tumor_morphology1.35135813
55MP0000685_abnormal_immune_system1.34291944
56MP0005166_decreased_susceptibility_to1.30573185
57MP0002254_reproductive_system_inflammat1.27802682
58MP0000920_abnormal_myelination1.26206347
59MP0000858_altered_metastatic_potential1.25352474
60MP0002837_dystrophic_cardiac_calcinosis1.24203297
61MP0005365_abnormal_bile_salt1.15575433
62MP0010155_abnormal_intestine_physiology1.11436505
63MP0005164_abnormal_response_to1.03485947
64MP0008260_abnormal_autophagy1.02226368
65MP0002090_abnormal_vision0.97456969
66MP0000716_abnormal_immune_system0.97288580
67MP0005647_abnormal_sex_gland0.94540747
68MP0000371_diluted_coat_color0.91709179
69MP0001727_abnormal_embryo_implantation0.91115341
70MP0005165_increased_susceptibility_to0.89460126
71MP0005257_abnormal_intraocular_pressure0.88296740
72MP0004883_abnormal_blood_vessel0.88163541
73MP0009763_increased_sensitivity_to0.86849803
74MP0003795_abnormal_bone_structure0.85888761
75MP0003634_abnormal_glial_cell0.84205393
76MP0004808_abnormal_hematopoietic_stem0.82993266
77MP0010307_abnormal_tumor_latency0.81408474
78MP0003091_abnormal_cell_migration0.81079112
79MP0005390_skeleton_phenotype0.79373546
80MP0002332_abnormal_exercise_endurance0.78880462
81MP0002429_abnormal_blood_cell0.75464398
82MP0005410_abnormal_fertilization0.74467019
83MP0009765_abnormal_xenobiotic_induced0.73009951
84MP0008874_decreased_physiological_sensi0.70394504
85MP0002398_abnormal_bone_marrow0.70107136
86MP0005319_abnormal_enzyme/_coenzyme0.69796208
87MP0003828_pulmonary_edema0.69443464
88MP0000689_abnormal_spleen_morphology0.68411843
89MP0000609_abnormal_liver_physiology0.66287835
90MP0005023_abnormal_wound_healing0.64809081
91MP0000465_gastrointestinal_hemorrhage0.62609088
92MP0000249_abnormal_blood_vessel0.61342424
93MP0003950_abnormal_plasma_membrane0.61271206
94MP0004019_abnormal_vitamin_homeostasis0.60369698
95MP0003633_abnormal_nervous_system0.59244383
96MP0001542_abnormal_bone_strength0.59063430
97MP0002722_abnormal_immune_system0.57213385
98MP0002933_joint_inflammation0.56820154
99MP0005595_abnormal_vascular_smooth0.56747935
100MP0005584_abnormal_enzyme/coenzyme_acti0.55636044

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)9.69993458
2Abnormality of liposaccharide metabolism (HP:0010968)9.69993458
3Abnormality of glycosphingolipid metabolism (HP:0004343)9.69993458
4Vacuolated lymphocytes (HP:0001922)6.27104991
5Increased cerebral lipofuscin (HP:0011813)5.71453187
6Abnormality of macrophages (HP:0004311)5.05991645
7Loss of speech (HP:0002371)4.96140061
8Dysostosis multiplex (HP:0000943)4.80242409
9Disinhibition (HP:0000734)4.74856364
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.57817472
11Neurofibrillary tangles (HP:0002185)4.00255766
12Systemic lupus erythematosus (HP:0002725)3.90777026
13Recurrent bacterial skin infections (HP:0005406)3.82136094
14Myocardial infarction (HP:0001658)3.76254142
15Mutism (HP:0002300)3.71495465
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.71293878
17Abnormality of polysaccharide metabolism (HP:0011012)3.71293878
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.71293878
19Eczematoid dermatitis (HP:0000976)3.65308657
20Recurrent abscess formation (HP:0002722)3.65231054
21Urinary glycosaminoglycan excretion (HP:0003541)3.54940360
22Mucopolysacchariduria (HP:0008155)3.54940360
23Autoimmune thrombocytopenia (HP:0001973)3.54138643
24Axonal loss (HP:0003447)3.51973036
25Nuclear cataract (HP:0100018)3.45324427
26Recurrent gram-negative bacterial infections (HP:0005420)3.45109625
27Apathy (HP:0000741)3.44377031
28Diminished motivation (HP:0000745)3.42657589
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.32621054
30Metaphyseal irregularity (HP:0003025)3.25744632
31Mediastinal lymphadenopathy (HP:0100721)2.97570775
32Agnosia (HP:0010524)2.92882744
33Cerebral inclusion bodies (HP:0100314)2.89935753
34Upper motor neuron abnormality (HP:0002127)2.83927483
35Hepatosplenomegaly (HP:0001433)2.78773805
36Progressive neurologic deterioration (HP:0002344)2.78136574
37Stomatitis (HP:0010280)2.71850524
38Increased serum ferritin (HP:0003281)2.68458733
39Purpura (HP:0000979)2.66108246
40Neuronal loss in central nervous system (HP:0002529)2.62241068
41Prolonged neonatal jaundice (HP:0006579)2.58076361
42Inappropriate behavior (HP:0000719)2.56979781
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.52674278
44Petechiae (HP:0000967)2.48433881
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.45820874
46Chronic obstructive pulmonary disease (HP:0006510)2.40454298
47Obstructive lung disease (HP:0006536)2.40454298
48Personality changes (HP:0000751)2.38761273
49Dementia (HP:0000726)2.34963609
50Nausea (HP:0002018)2.33265282
51Xanthomatosis (HP:0000991)2.33198258
52Abnormality of the periventricular white matter (HP:0002518)2.28655738
53Protuberant abdomen (HP:0001538)2.28164942
54Poor head control (HP:0002421)2.27994319
55Asymmetric septal hypertrophy (HP:0001670)2.25090355
56Multiple enchondromatosis (HP:0005701)2.19960433
57Supranuclear gaze palsy (HP:0000605)2.19576021
58Interstitial pulmonary disease (HP:0006530)2.16621432
59Pathologic fracture (HP:0002756)2.16185405
60Hematochezia (HP:0002573)2.12564135
61Increased CSF protein (HP:0002922)2.10901539
62Bone pain (HP:0002653)2.10724216
63Amyloidosis (HP:0011034)2.09877445
64Glomerulonephritis (HP:0000099)2.09687221
65Retinal atrophy (HP:0001105)2.06962303
66Abnormality of iron homeostasis (HP:0011031)2.05435082
67Orchitis (HP:0100796)2.05341395
68Peripheral demyelination (HP:0011096)2.04896114
69J-shaped sella turcica (HP:0002680)2.04648794
70Generalized aminoaciduria (HP:0002909)2.04480018
71Retrobulbar optic neuritis (HP:0100654)2.03358457
72Optic neuritis (HP:0100653)2.03358457
73Cardiomegaly (HP:0001640)2.03068737
74Myositis (HP:0100614)2.01357151
75Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97768028
76Vertebral compression fractures (HP:0002953)1.97051915
77Gingivitis (HP:0000230)1.95821039
78Recurrent skin infections (HP:0001581)1.88921357
79Basal ganglia calcification (HP:0002135)1.85459406
80Global brain atrophy (HP:0002283)1.82741126
81Malnutrition (HP:0004395)1.77680217
82Paralysis (HP:0003470)1.77509382
83Thoracic kyphosis (HP:0002942)1.77133781
84Polyneuropathy (HP:0001271)1.76309994
85Tetraparesis (HP:0002273)1.71731161
86Abnormality of transition element cation homeostasis (HP:0011030)1.71644417
87Pulmonary infiltrates (HP:0002113)1.68301744
88Abnormal trabecular bone morphology (HP:0100671)1.68115899
89Abnormality of the lumbar spine (HP:0100712)1.67880261
90T lymphocytopenia (HP:0005403)1.67762965
91Segmental peripheral demyelination/remyelination (HP:0003481)1.66267229
92Neoplasm of head and neck (HP:0012288)1.66196318
93Esophageal neoplasm (HP:0100751)1.66196318
94Thin bony cortex (HP:0002753)1.65060368
95Hypophosphatemia (HP:0002148)1.64360006
96Conjunctival telangiectasia (HP:0000524)1.63779401
97Symptomatic seizures (HP:0011145)1.56648083
98Complement deficiency (HP:0004431)1.56559780
99Multiple lipomas (HP:0001012)1.56521064
100Splenomegaly (HP:0001744)1.56109696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.89372811
2NME25.53621944
3BLK3.36402366
4GRK72.87132474
5TAOK22.84361242
6MAP3K142.60825291
7MAP3K112.41610681
8DDR22.36822499
9MAP2K32.18828124
10TBK12.07963271
11MAP3K32.01119323
12MATK1.99151784
13PIM21.93946090
14FGR1.91932895
15RIPK41.91007712
16ABL21.90827593
17ACVR1B1.84270485
18CSK1.83303841
19TAOK11.80178980
20TESK21.75446916
21MOS1.67766550
22TGFBR21.63785843
23IKBKB1.60226491
24CAMKK21.53958908
25IRAK41.51742407
26TYK21.46156308
27MAP3K131.41068487
28IKBKE1.30970809
29LIMK11.28416425
30PRPF4B1.28207556
31MAP3K11.26934274
32CAMK1D1.23392101
33PDK21.22918919
34ARAF1.21355934
35MAP3K51.18993591
36ZAP701.18805793
37ADRBK21.15771971
38CDC42BPA1.10979686
39TESK11.07546951
40MAP4K11.03896828
41MAP2K61.00892825
42NEK91.00453303
43BMPR20.95924418
44ERN10.94100848
45JAK30.94036693
46MARK30.93197958
47PAK40.87396631
48RIPK10.84338026
49SYK0.80793242
50LYN0.79312133
51CHUK0.79262977
52STK100.63528128
53TXK0.63365058
54ERBB40.63095718
55IRAK20.60747054
56PDPK10.53536749
57TTN0.51897123
58JAK20.50981105
59LCK0.50148514
60CAMK1G0.49147066
61PBK0.48176992
62CSF1R0.48155660
63MAP3K80.47386311
64HCK0.47264287
65BMX0.46411563
66PDK10.45208538
67PIM10.44991733
68MAPK40.44842885
69ABL10.43069665
70RPS6KC10.42680196
71RPS6KL10.42680196
72RPS6KA20.41280028
73CDK60.41226977
74PRKG20.40946947
75TAOK30.40928443
76JAK10.40109838
77MAP3K120.38739689
78MAPK120.38319056
79DYRK30.38165076
80BRAF0.36057699
81KIT0.35612969
82DAPK20.34813818
83TYRO30.32662666
84BTK0.31155871
85PDGFRA0.31151967
86KSR20.31116059
87RPS6KA60.30770646
88SCYL20.30086740
89STK240.28392960
90DAPK30.28066936
91CCNB10.27918971
92IRAK10.25689330
93EGFR0.24279607
94CSNK1G30.23811015
95CLK10.23497418
96GSK3A0.23281092
97CAMK2G0.22756011
98PAK10.22212893
99MAPK70.20919045
100ICK0.20673165

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.44103197
2Lysosome_Homo sapiens_hsa041424.13537258
3Rheumatoid arthritis_Homo sapiens_hsa053233.27459537
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.27137433
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.92363632
6Osteoclast differentiation_Homo sapiens_hsa043802.52784961
7Staphylococcus aureus infection_Homo sapiens_hsa051502.49927940
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.47815692
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.29320485
10Leishmaniasis_Homo sapiens_hsa051402.28212390
11Tuberculosis_Homo sapiens_hsa051522.10511370
12Collecting duct acid secretion_Homo sapiens_hsa049662.05427795
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.00305110
14Phagosome_Homo sapiens_hsa041451.96300590
15Asthma_Homo sapiens_hsa053101.94242869
16Malaria_Homo sapiens_hsa051441.90961638
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.84977097
18Allograft rejection_Homo sapiens_hsa053301.83192603
19TNF signaling pathway_Homo sapiens_hsa046681.80994098
20Pertussis_Homo sapiens_hsa051331.79219880
21Legionellosis_Homo sapiens_hsa051341.76640064
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.71721996
23Salmonella infection_Homo sapiens_hsa051321.71659213
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70635712
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70468952
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59672943
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50581479
28Graft-versus-host disease_Homo sapiens_hsa053321.49706990
29Vibrio cholerae infection_Homo sapiens_hsa051101.44801363
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39495788
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36400541
32Autoimmune thyroid disease_Homo sapiens_hsa053201.35878193
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.34193810
34Antigen processing and presentation_Homo sapiens_hsa046121.33541311
35Toxoplasmosis_Homo sapiens_hsa051451.25095581
36Type I diabetes mellitus_Homo sapiens_hsa049401.21209357
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19791978
38Influenza A_Homo sapiens_hsa051641.17644806
39Galactose metabolism_Homo sapiens_hsa000521.13696776
40Hematopoietic cell lineage_Homo sapiens_hsa046401.12381710
41Bladder cancer_Homo sapiens_hsa052191.10067182
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.07023899
43Sphingolipid metabolism_Homo sapiens_hsa006001.06836468
44Sulfur metabolism_Homo sapiens_hsa009201.02374799
45Shigellosis_Homo sapiens_hsa051311.01890657
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99333936
47B cell receptor signaling pathway_Homo sapiens_hsa046620.98574693
48Chemokine signaling pathway_Homo sapiens_hsa040620.98521320
49Viral myocarditis_Homo sapiens_hsa054160.89198926
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88324654
51PPAR signaling pathway_Homo sapiens_hsa033200.87785785
52Prion diseases_Homo sapiens_hsa050200.87699385
53African trypanosomiasis_Homo sapiens_hsa051430.87396461
54Apoptosis_Homo sapiens_hsa042100.82013437
55Herpes simplex infection_Homo sapiens_hsa051680.81663992
56Hepatitis C_Homo sapiens_hsa051600.80760743
57Mineral absorption_Homo sapiens_hsa049780.78767195
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73739857
59Complement and coagulation cascades_Homo sapiens_hsa046100.71884377
60Fructose and mannose metabolism_Homo sapiens_hsa000510.71755358
61Synaptic vesicle cycle_Homo sapiens_hsa047210.69721699
62Hepatitis B_Homo sapiens_hsa051610.67729160
63Steroid biosynthesis_Homo sapiens_hsa001000.67178710
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66721772
65Pentose phosphate pathway_Homo sapiens_hsa000300.66378822
66Amoebiasis_Homo sapiens_hsa051460.65079695
67Measles_Homo sapiens_hsa051620.63698959
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.61796437
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61154096
70Acute myeloid leukemia_Homo sapiens_hsa052210.61097502
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60470279
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59779935
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.58444866
74VEGF signaling pathway_Homo sapiens_hsa043700.53939925
75Glutathione metabolism_Homo sapiens_hsa004800.50488790
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.50473071
77T cell receptor signaling pathway_Homo sapiens_hsa046600.46349517
78Epstein-Barr virus infection_Homo sapiens_hsa051690.44310327
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.40815187
80HIF-1 signaling pathway_Homo sapiens_hsa040660.40579185
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.39927396
82Type II diabetes mellitus_Homo sapiens_hsa049300.38471834
83Prolactin signaling pathway_Homo sapiens_hsa049170.37022883
84Endocytosis_Homo sapiens_hsa041440.30495832
85Platelet activation_Homo sapiens_hsa046110.26871701
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25893578
87Renin-angiotensin system_Homo sapiens_hsa046140.23820444
88Fatty acid elongation_Homo sapiens_hsa000620.21795212
89Fatty acid biosynthesis_Homo sapiens_hsa000610.20381546
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19744281
91Notch signaling pathway_Homo sapiens_hsa043300.19002448
92GnRH signaling pathway_Homo sapiens_hsa049120.18689279
93HTLV-I infection_Homo sapiens_hsa051660.16865117
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14115893
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14111462
96Viral carcinogenesis_Homo sapiens_hsa052030.13477606
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13100995
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12714863
99Tryptophan metabolism_Homo sapiens_hsa003800.12171358
100Pancreatic cancer_Homo sapiens_hsa052120.11250835

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