TM4SF20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.49682626
2regulation of guanylate cyclase activity (GO:0031282)8.00900201
3angiotensin maturation (GO:0002003)7.68654649
4flavonoid metabolic process (GO:0009812)6.59434227
5lipoprotein transport (GO:0042953)6.41725805
6positive regulation of guanylate cyclase activity (GO:0031284)6.39567782
7vitamin A metabolic process (GO:0006776)6.17120755
8epoxygenase P450 pathway (GO:0019373)5.82270895
9digestive system process (GO:0022600)5.55886617
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.52823616
11fat-soluble vitamin biosynthetic process (GO:0042362)5.49802757
12UDP-N-acetylglucosamine metabolic process (GO:0006047)5.40655502
13regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.23047026
14endocrine process (GO:0050886)5.23047026
15regulation of systemic arterial blood pressure by hormone (GO:0001990)5.23047026
16regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.20137358
17actin filament depolymerization (GO:0030042)5.17803646
18virion attachment to host cell (GO:0019062)5.08129839
19adhesion of symbiont to host cell (GO:0044650)5.08129839
20purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.02688434
213-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.02688434
22fructose metabolic process (GO:0006000)4.97408188
23regulation of cGMP biosynthetic process (GO:0030826)4.90965436
24regulation of respiratory burst (GO:0060263)4.89872911
25regulation of bile acid biosynthetic process (GO:0070857)4.88381987
26drug catabolic process (GO:0042737)4.83162163
27regulation of triglyceride catabolic process (GO:0010896)4.74999695
28regulation of systemic arterial blood pressure (GO:0003073)4.74569631
29intestinal epithelial cell development (GO:0060576)4.66735380
30drug metabolic process (GO:0017144)4.56436609
31uronic acid metabolic process (GO:0006063)4.56197127
32glucuronate metabolic process (GO:0019585)4.56197127
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.50922303
34maintenance of gastrointestinal epithelium (GO:0030277)4.47731190
35sulfation (GO:0051923)4.38196005
36arginine metabolic process (GO:0006525)4.34895583
37positive regulation of lipoprotein lipase activity (GO:0051006)4.34778115
38positive regulation of triglyceride lipase activity (GO:0061365)4.34778115
39phospholipid efflux (GO:0033700)4.31826188
40membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.28246760
41sulfate transmembrane transport (GO:1902358)4.24745284
42transepithelial transport (GO:0070633)4.23099069
43plasma lipoprotein particle assembly (GO:0034377)4.17146561
44regulation of cGMP metabolic process (GO:0030823)4.11293891
45positive regulation of respiratory burst (GO:0060267)4.09604459
46antibacterial humoral response (GO:0019731)4.09189791
47adhesion of symbiont to host (GO:0044406)4.08358409
48positive regulation of glycoprotein biosynthetic process (GO:0010560)4.06585807
49calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.06530331
50modified amino acid transport (GO:0072337)4.06250037
51regulation of cholesterol esterification (GO:0010872)4.01285172
52antimicrobial humoral response (GO:0019730)4.00734240
53sperm capacitation (GO:0048240)3.98075835
54peptide catabolic process (GO:0043171)3.98062378
55positive regulation of pseudopodium assembly (GO:0031274)3.96604512
56glucose 6-phosphate metabolic process (GO:0051156)3.92134852
57bicarbonate transport (GO:0015701)3.90902716
58protein-lipid complex assembly (GO:0065005)3.90723596
59glycolipid catabolic process (GO:0019377)3.90304932
60purine nucleotide salvage (GO:0032261)3.89762769
61regulation of cellular extravasation (GO:0002691)3.88281486
62glycosphingolipid catabolic process (GO:0046479)3.81460152
63membrane repolarization during action potential (GO:0086011)3.78784711
64O-glycan processing (GO:0016266)3.76396885
65positive regulation of cGMP biosynthetic process (GO:0030828)3.75154804
66very-low-density lipoprotein particle assembly (GO:0034379)3.75044306
67regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.74714492
68vitamin transmembrane transport (GO:0035461)3.73349708
69thyroid hormone metabolic process (GO:0042403)3.72772752
70transcytosis (GO:0045056)3.69261860
71bile acid and bile salt transport (GO:0015721)3.68856496
72lipoprotein metabolic process (GO:0042157)3.67589724
73response to hepatocyte growth factor (GO:0035728)3.65563239
74cellular response to hepatocyte growth factor stimulus (GO:0035729)3.65563239
75positive regulation of glycoprotein metabolic process (GO:1903020)3.63411077
76nitrogen cycle metabolic process (GO:0071941)3.62309279
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60246942
78regulation of chemokine secretion (GO:0090196)3.59931130
79diacylglycerol metabolic process (GO:0046339)3.59735664
80alkaloid metabolic process (GO:0009820)3.58218536
81cytidine deamination (GO:0009972)3.57464928
82cytidine metabolic process (GO:0046087)3.57464928
83cytidine catabolic process (GO:0006216)3.57464928
84digestion (GO:0007586)3.55611009
85regulation of pseudopodium assembly (GO:0031272)3.54835594
86innate immune response in mucosa (GO:0002227)3.53928538
87renal system process involved in regulation of blood volume (GO:0001977)3.53692172
88sulfate transport (GO:0008272)3.53135787
89negative regulation of keratinocyte proliferation (GO:0010839)3.52365703
90sulfur compound transport (GO:0072348)3.52145014
91drinking behavior (GO:0042756)3.51744775
92NADH metabolic process (GO:0006734)3.50336210
93ventricular cardiac muscle cell action potential (GO:0086005)3.42560175
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42402503
95cholesterol efflux (GO:0033344)3.42261546
96vitamin transport (GO:0051180)3.41887533
97glomerular filtration (GO:0003094)3.39317734
98cholesterol homeostasis (GO:0042632)3.39286042
99sterol homeostasis (GO:0055092)3.37968538
100fat-soluble vitamin metabolic process (GO:0006775)3.34097196
101bile acid metabolic process (GO:0008206)3.31460443
102cholesterol transport (GO:0030301)3.31299939
103sterol transport (GO:0015918)3.31299939
104glutamine family amino acid biosynthetic process (GO:0009084)3.29855692
105cellular response to nitric oxide (GO:0071732)3.28979808
106antigen processing and presentation of endogenous antigen (GO:0019883)3.28885884
107epithelial structure maintenance (GO:0010669)3.28426325
108regulation of protein glycosylation (GO:0060049)3.25967892
109glycerol metabolic process (GO:0006071)3.25943908
110glycosylceramide metabolic process (GO:0006677)3.25280949
111positive regulation of cGMP metabolic process (GO:0030825)3.23345581
112ceramide catabolic process (GO:0046514)3.22818244
113mRNA modification (GO:0016556)3.20651931
114glycoside metabolic process (GO:0016137)3.20309158
115negative regulation of sterol transport (GO:0032372)3.19794653
116negative regulation of cholesterol transport (GO:0032375)3.19794653
117cyclooxygenase pathway (GO:0019371)3.18345795
118disruption of cells of other organism (GO:0044364)3.17728109
119killing of cells of other organism (GO:0031640)3.17728109
120auditory receptor cell differentiation (GO:0042491)3.17479053
121regulation of digestive system process (GO:0044058)3.16146189
122midgut development (GO:0007494)3.15921469
123nucleotide-sugar biosynthetic process (GO:0009226)3.13255488
124arginine catabolic process (GO:0006527)3.11879131
125hepatocyte apoptotic process (GO:0097284)3.11832953
126vitamin biosynthetic process (GO:0009110)3.09632567
127cGMP-mediated signaling (GO:0019934)3.09231654
128mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08338687
129defense response to fungus (GO:0050832)3.07904003
130cGMP biosynthetic process (GO:0006182)3.07286329
131nucleoside diphosphate biosynthetic process (GO:0009133)3.07021826
132glomerulus development (GO:0032835)3.06924482
133regulation of vitamin metabolic process (GO:0030656)3.05775684
134regulation of hydrogen peroxide metabolic process (GO:0010310)3.05343928
135mucosal immune response (GO:0002385)3.04252327
136renal filtration (GO:0097205)3.04040261
137response to nitric oxide (GO:0071731)3.03589126
138positive regulation of T cell differentiation in thymus (GO:0033089)3.03513502
139cellular glucuronidation (GO:0052695)3.02431718
140eosinophil chemotaxis (GO:0048245)3.01983293
141positive regulation of fatty acid biosynthetic process (GO:0045723)3.01661261
142sexual reproduction (GO:0019953)3.00964696
143GDP-mannose metabolic process (GO:0019673)3.00479020
144hormone catabolic process (GO:0042447)2.99877924
145receptor guanylyl cyclase signaling pathway (GO:0007168)2.99724833
146regulation of cholesterol homeostasis (GO:2000188)2.97899183
147phenylpropanoid metabolic process (GO:0009698)2.92769997
148exogenous drug catabolic process (GO:0042738)2.90308022
149urea metabolic process (GO:0019627)2.90001017
150urea cycle (GO:0000050)2.90001017
151regulation of viral release from host cell (GO:1902186)2.89925636
152diol metabolic process (GO:0034311)2.89445540
153homocysteine metabolic process (GO:0050667)2.89341110
154proline biosynthetic process (GO:0006561)2.88173412
155peptide hormone processing (GO:0016486)2.87847390
156organ or tissue specific immune response (GO:0002251)2.85852042
157drug transport (GO:0015893)2.85719250
158intestinal absorption (GO:0050892)11.6790964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human6.32066021
2HNF4A_19761587_ChIP-ChIP_CACO-2_Human4.30627907
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.19686135
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.83005678
5* GATA4_25053715_ChIP-Seq_YYC3_Human3.62910993
6GATA6_25053715_ChIP-Seq_YYC3_Human3.33245482
7SOX2_20726797_ChIP-Seq_SW620_Human3.22647914
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.21142635
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90969031
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.85035749
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.79626403
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.62438951
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62036749
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.50825928
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.33319649
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.30446900
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25077935
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.12397921
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12162298
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.11950475
21TP63_17297297_ChIP-ChIP_HaCaT_Human11.7930560
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.86728250
23KLF5_25053715_ChIP-Seq_YYC3_Human1.85969844
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85604064
25AR_21909140_ChIP-Seq_LNCAP_Human1.82673948
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79560007
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79477626
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.71377293
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71239099
30* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60792005
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.55251046
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.55035409
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53883629
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53185549
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.51559109
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43324753
37HNF4A_19822575_ChIP-Seq_HepG2_Human1.43317766
38FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42928730
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42880233
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35805980
41VDR_22108803_ChIP-Seq_LS180_Human1.34392005
42ATF3_27146783_Chip-Seq_COLON_Human1.34223920
43RACK7_27058665_Chip-Seq_MCF-7_Human1.31855749
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30776392
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29939573
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28718340
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24387807
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21300254
49RXR_22108803_ChIP-Seq_LS180_Human1.19380414
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19219853
51EGR1_19032775_ChIP-ChIP_M12_Human1.17290861
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14748372
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12309455
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11185035
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11185035
56CEBPB_22108803_ChIP-Seq_LS180_Human1.09860724
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07161998
58* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06601309
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05792199
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05517441
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.05457685
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04844867
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02925456
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02775669
65SA1_27219007_Chip-Seq_Bcells_Human1.01926078
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01639564
67LXR_22292898_ChIP-Seq_THP-1_Human1.01568291
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.99652023
69ELF5_23300383_ChIP-Seq_T47D_Human0.99418104
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99029315
71FOXA2_19822575_ChIP-Seq_HepG2_Human0.97648511
72STAT1_20625510_ChIP-Seq_HELA_Human0.96955992
73P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96467906
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96006208
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95334208
76TAF2_19829295_ChIP-Seq_ESCs_Human0.95251166
77ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95128185
78* NANOG_20526341_ChIP-Seq_ESCs_Human0.94739601
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94521884
80GATA3_24758297_ChIP-Seq_MCF-7_Human0.93740248
81GATA2_19941826_ChIP-Seq_K562_Human0.92481489
82CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92355866
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92252828
84NCOR_22424771_ChIP-Seq_293T_Human0.91585177
85HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90470966
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90387241
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90286119
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89441378
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89348828
90* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88677971
91P53_21459846_ChIP-Seq_SAOS-2_Human0.88543590
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88301182
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88107726
94AR_20517297_ChIP-Seq_VCAP_Human0.87806998
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87794804
96CREB1_26743006_Chip-Seq_LNCaP_Human0.87532881
97VDR_24787735_ChIP-Seq_THP-1_Human0.87220472
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86511874
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.86034748
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85978314
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85066161
102ZNF263_19887448_ChIP-Seq_K562_Human0.84977126
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84962427
104GATA1_22025678_ChIP-Seq_K562_Human0.84875685
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84014124
106DROSHA_22980978_ChIP-Seq_HELA_Human0.84010052
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83954714
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83815454
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.83802007
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83664969
111TCF4_22108803_ChIP-Seq_LS180_Human0.83343936
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83274807
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82735489
114BCAT_22108803_ChIP-Seq_LS180_Human0.82305867
115PHF8_20622854_ChIP-Seq_HELA_Human0.81975407
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81637428
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81562184
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81147529
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.80293707
120CTCF_27219007_Chip-Seq_Bcells_Human0.79762288
121TP63_23658742_ChIP-Seq_EP156T_Human0.77550742
122GATA1_19941826_ChIP-Seq_K562_Human0.77517344
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77394641
124TP63_22573176_ChIP-Seq_HFKS_Human0.77195540
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77087688
126CDX2_22108803_ChIP-Seq_LS180_Human0.76934244
127* FOXA1_25552417_ChIP-Seq_VCAP_Human0.76277241
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75558535
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.74983352
130* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74723937
131* FOXA1_25329375_ChIP-Seq_VCAP_Human0.74723937
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73008435
133ZNF217_24962896_ChIP-Seq_MCF-7_Human0.72929430
134JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72161345
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70255965
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69819906
137* MYC_19829295_ChIP-Seq_ESCs_Human0.69692556
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.68480493
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.66429968
140BCL6_27268052_Chip-Seq_Bcells_Human0.66309404
141TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.65782698
142STAT1_17558387_ChIP-Seq_HELA_Human0.64753661
143BCOR_27268052_Chip-Seq_Bcells_Human0.64123179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.17232590
2MP0001666_abnormal_nutrient_absorption5.23334657
3MP0000462_abnormal_digestive_system4.09464377
4MP0010234_abnormal_vibrissa_follicle3.96522496
5MP0009379_abnormal_foot_pigmentation3.89802058
6MP0004264_abnormal_extraembryonic_tissu3.65979920
7MP0005085_abnormal_gallbladder_physiolo3.40967552
8MP0002139_abnormal_hepatobiliary_system3.27511251
9MP0003866_abnormal_defecation3.12957437
10MP0003252_abnormal_bile_duct3.00418757
11MP0009840_abnormal_foam_cell2.90799962
12MP0001663_abnormal_digestive_system2.74994675
13MP0005381_digestive/alimentary_phenotyp2.61340465
14MP0010155_abnormal_intestine_physiology2.59928663
15MP0003300_gastrointestinal_ulcer2.58017547
16MP0003183_abnormal_peptide_metabolism2.51012220
17MP0001873_stomach_inflammation2.47607972
18MP0000490_abnormal_crypts_of2.44330014
19MP0008875_abnormal_xenobiotic_pharmacok2.37142672
20MP0000537_abnormal_urethra_morphology2.33628431
21MP0002822_catalepsy2.31369868
22MP0001664_abnormal_digestion2.17405922
23MP0008004_abnormal_stomach_pH2.06179155
24MP0010329_abnormal_lipoprotein_level2.02172481
25MP0004019_abnormal_vitamin_homeostasis1.98471994
26MP0000477_abnormal_intestine_morphology1.92998075
27MP0004858_abnormal_nervous_system1.90138982
28MP0005365_abnormal_bile_salt1.80460606
29MP0004147_increased_porphyrin_level1.77760974
30MP0005409_darkened_coat_color1.73141268
31MP0009697_abnormal_copulation1.72364832
32MP0000538_abnormal_urinary_bladder1.70084758
33MP0010352_gastrointestinal_tract_polyps1.68664479
34MP0004043_abnormal_pH_regulation1.64134841
35MP0005377_hearing/vestibular/ear_phenot1.63327936
36MP0003878_abnormal_ear_physiology1.63327936
37MP0004782_abnormal_surfactant_physiolog1.59661496
38MP0001501_abnormal_sleep_pattern1.52638723
39MP0006054_spinal_hemorrhage1.44959105
40MP0003283_abnormal_digestive_organ1.44026873
41MP0008872_abnormal_physiological_respon1.42900801
42MP0005084_abnormal_gallbladder_morpholo1.34996791
43MP0002277_abnormal_respiratory_mucosa1.23289435
44MP0003693_abnormal_embryo_hatching1.22596014
45MP0002796_impaired_skin_barrier1.19795956
46MP0003806_abnormal_nucleotide_metabolis1.15977032
47MP0009643_abnormal_urine_homeostasis1.13640718
48MP0005670_abnormal_white_adipose1.11590674
49MP0004270_analgesia1.09156876
50MP0001849_ear_inflammation1.08067802
51MP0001756_abnormal_urination1.06779193
52MP0005448_abnormal_energy_balance1.04269428
53MP0003705_abnormal_hypodermis_morpholog1.03630206
54MP0003315_abnormal_perineum_morphology0.97386550
55MP0000230_abnormal_systemic_arterial0.97371702
56MP0005535_abnormal_body_temperature0.94798342
57MP0002098_abnormal_vibrissa_morphology0.93367292
58MP0005167_abnormal_blood-brain_barrier0.93017940
59MP0000470_abnormal_stomach_morphology0.92922489
60MP0000467_abnormal_esophagus_morphology0.92690800
61MP0002089_abnormal_postnatal_growth/wei0.92317110
62MP0003453_abnormal_keratinocyte_physiol0.92097716
63MP0009785_altered_susceptibility_to0.92024606
64MP0002254_reproductive_system_inflammat0.91882594
65MP0001765_abnormal_ion_homeostasis0.91472153
66MP0001485_abnormal_pinna_reflex0.90539624
67MP0005584_abnormal_enzyme/coenzyme_acti0.89804046
68MP0003718_maternal_effect0.89613785
69MP0003724_increased_susceptibility_to0.89231853
70MP0000613_abnormal_salivary_gland0.89129697
71MP0009384_cardiac_valve_regurgitation0.88596332
72MP0002132_abnormal_respiratory_system0.88561546
73MP0005636_abnormal_mineral_homeostasis0.87903819
74MP0005332_abnormal_amino_acid0.87118753
75MP0002876_abnormal_thyroid_physiology0.83094767
76MP0010678_abnormal_skin_adnexa0.82521790
77MP0000566_synostosis0.82419669
78MP0004947_skin_inflammation0.81553731
79MP0003191_abnormal_cellular_cholesterol0.80908338
80MP0005451_abnormal_body_composition0.79043087
81MP0003329_amyloid_beta_deposits0.78486761
82MP0001835_abnormal_antigen_presentation0.78456918
83MP0001790_abnormal_immune_system0.77859362
84MP0005387_immune_system_phenotype0.77859362
85MP0009764_decreased_sensitivity_to0.77481112
86MP0002971_abnormal_brown_adipose0.77444247
87MP0008469_abnormal_protein_level0.77076296
88MP0000678_abnormal_parathyroid_gland0.76710301
89MP0002163_abnormal_gland_morphology0.75892559
90MP0005501_abnormal_skin_physiology0.75778706
91MP0002166_altered_tumor_susceptibility0.74601612
92MP0000465_gastrointestinal_hemorrhage0.74366220
93MP0005166_decreased_susceptibility_to0.73914615
94MP0003868_abnormal_feces_composition0.73396165
95MP0008775_abnormal_heart_ventricle0.71899165
96MP0000609_abnormal_liver_physiology0.71217483
97MP0000604_amyloidosis0.71005282
98MP0005025_abnormal_response_to0.70717737
99MP0005174_abnormal_tail_pigmentation0.70092223
100MP0002118_abnormal_lipid_homeostasis0.69363538
101MP0005671_abnormal_response_to0.68452581
102MP0003941_abnormal_skin_development0.68361344
103MP0009115_abnormal_fat_cell0.68030243
104MP0001764_abnormal_homeostasis0.66476819
105MP0001216_abnormal_epidermal_layer0.66229261
106MP0003436_decreased_susceptibility_to0.62705514
107MP0001881_abnormal_mammary_gland0.62448583
108MP0005319_abnormal_enzyme/_coenzyme0.62044893
109MP0002136_abnormal_kidney_physiology0.61287184
110MP0006082_CNS_inflammation0.59327523
111MP0000249_abnormal_blood_vessel0.56950872
112MP0003787_abnormal_imprinting0.55983316
113MP0009333_abnormal_splenocyte_physiolog0.55383663
114MP0003123_paternal_imprinting0.54454401
115MP0005367_renal/urinary_system_phenotyp0.54388728
116MP0000516_abnormal_urinary_system0.54388728
117MP0009053_abnormal_anal_canal0.54326004
118MP0000015_abnormal_ear_pigmentation0.53112171
119MP0003119_abnormal_digestive_system0.53104907
120MP0003953_abnormal_hormone_level0.52989661
121MP0002896_abnormal_bone_mineralization0.52870603
122MP0002148_abnormal_hypersensitivity_rea0.51291668
123MP0002078_abnormal_glucose_homeostasis0.51031128
124MP0000681_abnormal_thyroid_gland0.50335177
125MP0002396_abnormal_hematopoietic_system0.49681118
126MP0002060_abnormal_skin_morphology0.49506635
127MP0004957_abnormal_blastocyst_morpholog0.49499996
128MP0005165_increased_susceptibility_to0.48962871
129MP0002006_tumorigenesis0.47305718
130MP0005334_abnormal_fat_pad0.46708281
131MP0004484_altered_response_of0.46545507
132MP0005266_abnormal_metabolism0.46125139
133MP0003950_abnormal_plasma_membrane0.46018563
134MP0003879_abnormal_hair_cell0.44518040
135MP0010386_abnormal_urinary_bladder0.44178820
136MP0009780_abnormal_chondrocyte_physiolo0.42402113
137MP0009642_abnormal_blood_homeostasis0.41650415
138MP0005310_abnormal_salivary_gland0.41619694
139MP0002138_abnormal_hepatobiliary_system0.41165132
140MP0001845_abnormal_inflammatory_respons0.41106254
141MP0001188_hyperpigmentation0.39534460

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)9.42457958
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.56240632
3Ventricular fibrillation (HP:0001663)5.53592824
4Right ventricular cardiomyopathy (HP:0011663)5.20737419
5Malnutrition (HP:0004395)5.17904201
6Acanthocytosis (HP:0001927)4.87735518
7Hypobetalipoproteinemia (HP:0003563)4.83187186
8Conjugated hyperbilirubinemia (HP:0002908)4.81131848
9Autoimmune thrombocytopenia (HP:0001973)4.61366695
10Systemic lupus erythematosus (HP:0002725)4.34847483
11Congenital sensorineural hearing impairment (HP:0008527)4.30450302
12Autoimmune hemolytic anemia (HP:0001890)4.21581115
13Confusion (HP:0001289)4.03943628
14Glycosuria (HP:0003076)3.80779537
15Abnormality of urine glucose concentration (HP:0011016)3.80779537
16Rectal prolapse (HP:0002035)3.78052937
17Abnormality of proline metabolism (HP:0010907)3.76891507
18Hydroxyprolinuria (HP:0003080)3.76891507
19Abdominal distention (HP:0003270)3.75032745
20Pustule (HP:0200039)3.61511299
21Decreased circulating renin level (HP:0003351)3.47988407
22Abnormality of glycine metabolism (HP:0010895)3.47638749
23Abnormality of serine family amino acid metabolism (HP:0010894)3.47638749
24Cupped ribs (HP:0000887)3.44582875
25Chronic diarrhea (HP:0002028)3.38161733
26Abnormal hemoglobin (HP:0011902)3.37806142
27Fat malabsorption (HP:0002630)3.33743081
28Gastrointestinal dysmotility (HP:0002579)3.27716597
29Alkalosis (HP:0001948)3.22123422
30Abnormal biliary tract morphology (HP:0012440)3.14253013
31Cheilitis (HP:0100825)3.06158817
32Facial shape deformation (HP:0011334)3.04058183
33Potter facies (HP:0002009)3.04058183
34Villous atrophy (HP:0011473)3.00088090
35Abnormality of small intestinal villus morphology (HP:0011472)3.00088090
36Hyperuricemia (HP:0002149)2.91268884
37Increased purine levels (HP:0004368)2.91268884
38Abnormality of the vitamin B12 metabolism (HP:0004341)2.89484159
39Dehydration (HP:0001944)2.84269635
40Syncope (HP:0001279)2.83469661
41Abnormality of chloride homeostasis (HP:0011422)2.83440241
42Woolly hair (HP:0002224)2.83391408
43Eczematoid dermatitis (HP:0000976)2.80583336
44Widely patent fontanelles and sutures (HP:0004492)2.80550593
45B lymphocytopenia (HP:0010976)2.78745648
46Abnormality of B cell number (HP:0010975)2.78745648
47Mesangial abnormality (HP:0001966)2.78550403
48Poikilocytosis (HP:0004447)2.76023030
49Xanthomatosis (HP:0000991)2.75432954
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.75361672
51Steatorrhea (HP:0002570)2.75285966
52Hyperphosphaturia (HP:0003109)2.73199137
53Pigmentary retinal degeneration (HP:0001146)2.72976300
54Abnormality of renin-angiotensin system (HP:0000847)2.70185386
55Abnormality of vitamin B metabolism (HP:0004340)2.68603501
56Intrahepatic cholestasis (HP:0001406)2.68521895
57Hypolipoproteinemia (HP:0010981)2.68414835
58Hypophosphatemia (HP:0002148)2.57579916
59Pili torti (HP:0003777)2.53142486
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.52834025
61Hyperactive renin-angiotensin system (HP:0000841)2.52644250
62Palpitations (HP:0001962)2.51942639
63Abnormality of the gastric mucosa (HP:0004295)2.50134444
64Cerebral palsy (HP:0100021)2.48434498
65Hyperglycinuria (HP:0003108)2.46239553
66Biliary tract neoplasm (HP:0100574)2.44267308
67Thin bony cortex (HP:0002753)2.43611590
68Megaloblastic anemia (HP:0001889)2.41849206
69Abnormality of nucleobase metabolism (HP:0010932)2.41324196
70Focal segmental glomerulosclerosis (HP:0000097)2.40446134
71Ventricular arrhythmia (HP:0004308)2.39113439
72Lipid accumulation in hepatocytes (HP:0006561)2.36465400
73Fragile skin (HP:0001030)2.35503633
74Hypoalbuminemia (HP:0003073)2.35174628
75Abnormal albumin level (HP:0012116)2.35174628
76Micronodular cirrhosis (HP:0001413)2.34714926
77Pancreatitis (HP:0001733)2.34482791
78Male infertility (HP:0003251)2.34125355
79Increased muscle lipid content (HP:0009058)2.32256107
80Severe combined immunodeficiency (HP:0004430)2.31386829
81Glomerulonephritis (HP:0000099)2.31190274
82Ankyloglossia (HP:0010296)2.30219518
83Enlarged epiphyses (HP:0010580)2.28663483
84Abnormal urine phosphate concentration (HP:0012599)2.27683855
85Combined immunodeficiency (HP:0005387)2.27391962
86Abnormality of magnesium homeostasis (HP:0004921)2.26958560
87Symptomatic seizures (HP:0011145)2.25471017
88Flat acetabular roof (HP:0003180)2.25441810
89Nephritis (HP:0000123)2.25051538
90Increased IgE level (HP:0003212)2.24725354
91Hemorrhage of the eye (HP:0011885)2.24182218
92Abnormality of vitamin metabolism (HP:0100508)2.23973534
93Hepatic necrosis (HP:0002605)2.23179394
94Hypotension (HP:0002615)2.21389455
95Increased intramyocellular lipid droplets (HP:0012240)2.20077857
96Premature loss of primary teeth (HP:0006323)2.18233878
97Increased mean platelet volume (HP:0011877)2.18196880
98Dicarboxylic aciduria (HP:0003215)2.16848487
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16848487
100Increased hepatocellular lipid droplets (HP:0006565)2.14978462
101Hyperammonemia (HP:0001987)2.14821948
102Epidermoid cyst (HP:0200040)2.13448862
103Milia (HP:0001056)2.12873057
104Nausea (HP:0002018)2.11016170
105Hyperphosphatemia (HP:0002905)2.09083561
106Hepatocellular necrosis (HP:0001404)2.06108151
107Abnormality of purine metabolism (HP:0004352)2.05631964
108Goiter (HP:0000853)2.04449416
109Abnormality of sulfur amino acid metabolism (HP:0004339)2.04011591
110Wide cranial sutures (HP:0010537)2.03117271
111Macrocytic anemia (HP:0001972)2.03071962
112Gingivitis (HP:0000230)2.02717247
113Abnormality of pyrimidine metabolism (HP:0004353)2.02709068
114Abnormal glucose tolerance (HP:0001952)2.02641422
115Abnormality of complement system (HP:0005339)2.02158201
116Prolonged QT interval (HP:0001657)2.01639864
117Metabolic alkalosis (HP:0200114)2.00921104
118Abnormality of placental membranes (HP:0011409)2.00880407
119Amniotic constriction ring (HP:0009775)2.00880407
120Abnormal EKG (HP:0003115)2.00604183
121Subcapsular cataract (HP:0000523)1.99802944
122Complement deficiency (HP:0004431)1.99676723
123Reticulocytopenia (HP:0001896)1.98944894
124Plantar hyperkeratosis (HP:0007556)1.98485297
125Metabolic acidosis (HP:0001942)1.98351344
126Hyperparathyroidism (HP:0000843)1.96636241
127Fragile nails (HP:0001808)1.95692596
128Proximal tubulopathy (HP:0000114)1.95398252
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94633823
130Protuberant abdomen (HP:0001538)1.93855503
131Mildly elevated creatine phosphokinase (HP:0008180)1.93115101
132Chorioretinal atrophy (HP:0000533)1.93089232
133Gout (HP:0001997)1.93025960
134Nephrolithiasis (HP:0000787)1.92053008
135Abnormality of the costochondral junction (HP:0000919)1.89022729
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88804921
137Lethargy (HP:0001254)1.88201858
138Mitochondrial inheritance (HP:0001427)1.87749358
139Irritability (HP:0000737)1.87190909
140Trismus (HP:0000211)1.87165940
141Abnormality of the 1st metacarpal (HP:0010009)1.87076147
142Posterior subcapsular cataract (HP:0007787)1.86702582
143Delayed epiphyseal ossification (HP:0002663)1.86155732
144Glomerulosclerosis (HP:0000096)1.84357300
145Colon cancer (HP:0003003)1.83845461
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83722551
147Abnormal platelet volume (HP:0011876)1.83669229
148Renal tubular acidosis (HP:0001947)1.81870452
149Growth hormone excess (HP:0000845)1.78267543
150Vomiting (HP:0002013)1.69362322
151Hypocalcemia (HP:0002901)1.68843968
152Skin rash (HP:0000988)1.65839004
153Hypokalemia (HP:0002900)1.65549090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK27.53363220
2FRK5.58193167
3MST1R5.46654438
4NME14.27457233
5MST44.00259137
6PRKG23.46248149
7NUAK12.80258592
8MAP2K22.74603634
9EPHA32.20700422
10TNIK2.08512696
11EPHA22.03827722
12PBK2.02237994
13MAP3K21.97314861
14MAP2K61.96044528
15PIK3CA1.93901804
16EPHB21.88620687
17FGFR41.79179938
18GRK61.76990838
19RIPK11.74637930
20MET1.68195525
21NLK1.63832794
22PTK61.62546105
23TYK21.54401554
24STK391.53424699
25TTK1.41353910
26ADRBK21.39916869
27TESK11.39176962
28MAP3K101.30498670
29MAP3K111.30481222
30TAOK31.25670354
31CASK1.23794634
32EPHA41.19651608
33STK241.18666832
34KSR21.10268544
35ERBB21.09027392
36FGFR31.08732649
37MYLK1.06946619
38IRAK11.06325707
39MAP3K80.92722693
40IRAK30.89514820
41MAP2K10.87816376
42DDR20.87246450
43BMPR20.82885501
44AKT30.80235731
45AURKB0.80007377
46TLK10.79111285
47MATK0.78421910
48ERN10.77893843
49PRKCI0.76826191
50OXSR10.71821028
51PTK20.70180191
52MAP3K10.69173700
53PRKAA20.66471547
54PKN20.64858162
55DAPK20.64221795
56TAOK10.60817392
57SCYL20.60339704
58MAPK110.60338558
59STK100.60259249
60PAK40.58074228
61GRK10.57879093
62KIT0.54941310
63PRKCZ0.54692172
64FER0.51714328
65WNK40.51636299
66BMX0.51524550
67PDK10.51322131
68PASK0.50505384
69JAK10.50256186
70TESK20.48724961
71MAP3K70.47442163
72CAMK2D0.47086000
73IKBKE0.46690637
74PIM10.45969813
75STK38L0.43471231
76CSF1R0.39867467
77SYK0.39022781
78PRKCD0.38621291
79TEC0.38611696
80CDK90.38393815
81JAK20.38321837
82ERBB40.37646721
83LATS10.36925785
84MAP3K120.36823722
85PRKAA10.35858572
86ITK0.34996481
87NME20.34599187
88TBK10.33901896
89PAK10.33666716
90PRKCA0.33495379
91ABL20.32843857
92PIM20.32763637
93CAMK2G0.30657254
94BCR0.30272635
95FYN0.29636547
96PAK30.29466531
97MUSK0.29263412
98LIMK10.29239943
99DMPK0.28690003
100CSNK1A10.28096227
101YES10.27673873
102PRKCE0.27491384
103MAP3K30.27286089
104MELK0.27137799
105TXK0.27039000
106BMPR1B0.25995781
107CAMK2A0.25695666
108LYN0.25533129
109DAPK10.25505774
110IGF1R0.25346076
111MAPKAPK20.24582898
112PRKACA0.23446722
113RET0.23343833
114ROCK10.23096589
115JAK30.23040998
116MAP4K10.22887713
117CAMK2B0.21792480
118RIPK40.21166816
119ZAP700.20784732
120PDPK10.19926648
121RPS6KB20.19918775
122PRKACG0.19821949
123LRRK20.19806782
124CSK0.18547611
125ACVR1B0.18326536
126CDK190.18124018
127NEK90.17332558
128SRC0.17130214
129CDK60.16830146
130EPHB10.15551574
131DYRK1B0.15359726
132CAMKK10.14451938
133FGR0.14306520
134CDC42BPA0.14248379
135PRKCQ0.13749055
136PDGFRA0.12874234
137EIF2AK10.12872918
138PDK20.12392393
139MAP3K90.12318699
140BLK0.11095041

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.32564834
2Mineral absorption_Homo sapiens_hsa049784.45063995
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.23755333
4Renin-angiotensin system_Homo sapiens_hsa046143.22177391
5Vitamin digestion and absorption_Homo sapiens_hsa049773.14153038
6Sulfur metabolism_Homo sapiens_hsa009203.07510099
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.68545978
8Folate biosynthesis_Homo sapiens_hsa007902.52841274
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49200239
10Galactose metabolism_Homo sapiens_hsa000522.34395923
11Fructose and mannose metabolism_Homo sapiens_hsa000512.21343883
12Bile secretion_Homo sapiens_hsa049762.19951576
13Protein digestion and absorption_Homo sapiens_hsa049742.18648711
14Starch and sucrose metabolism_Homo sapiens_hsa005002.17642013
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.10968265
16Caffeine metabolism_Homo sapiens_hsa002321.98308943
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82125359
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79501042
19Histidine metabolism_Homo sapiens_hsa003401.78983279
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74933986
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74685107
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71074739
23Glutathione metabolism_Homo sapiens_hsa004801.70311656
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.57445805
25Asthma_Homo sapiens_hsa053101.56376500
26Nitrogen metabolism_Homo sapiens_hsa009101.55686250
27Glycerolipid metabolism_Homo sapiens_hsa005611.36124457
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33126160
29Tryptophan metabolism_Homo sapiens_hsa003801.32658608
30Ribosome_Homo sapiens_hsa030101.30393804
31Pentose phosphate pathway_Homo sapiens_hsa000301.28810469
32Fatty acid degradation_Homo sapiens_hsa000711.25316551
33Oxidative phosphorylation_Homo sapiens_hsa001901.20362734
34Allograft rejection_Homo sapiens_hsa053301.13084445
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10417061
36Parkinsons disease_Homo sapiens_hsa050121.09770934
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07151451
38Autoimmune thyroid disease_Homo sapiens_hsa053201.05467418
39Arginine and proline metabolism_Homo sapiens_hsa003301.05432000
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04336265
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01873880
42Graft-versus-host disease_Homo sapiens_hsa053321.01206516
43Arginine biosynthesis_Homo sapiens_hsa002200.97074618
44PPAR signaling pathway_Homo sapiens_hsa033200.96578070
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96320393
46Alzheimers disease_Homo sapiens_hsa050100.96316395
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95227255
48Thyroid hormone synthesis_Homo sapiens_hsa049180.93738062
49Staphylococcus aureus infection_Homo sapiens_hsa051500.91674556
50Sphingolipid metabolism_Homo sapiens_hsa006000.90302613
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90089210
52Pancreatic secretion_Homo sapiens_hsa049720.88902796
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86255873
54Type I diabetes mellitus_Homo sapiens_hsa049400.85504516
55Carbon metabolism_Homo sapiens_hsa012000.83846467
56Tight junction_Homo sapiens_hsa045300.83500030
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.82513354
58ABC transporters_Homo sapiens_hsa020100.81574471
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.79582087
60Chemical carcinogenesis_Homo sapiens_hsa052040.79215268
61Pyruvate metabolism_Homo sapiens_hsa006200.78630666
62Retinol metabolism_Homo sapiens_hsa008300.78599623
63Arachidonic acid metabolism_Homo sapiens_hsa005900.77877846
64Linoleic acid metabolism_Homo sapiens_hsa005910.77254235
65Huntingtons disease_Homo sapiens_hsa050160.71585472
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60821005
67Phenylalanine metabolism_Homo sapiens_hsa003600.60440022
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60127494
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59355103
70Butanoate metabolism_Homo sapiens_hsa006500.58928205
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58903623
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.57832138
73Bladder cancer_Homo sapiens_hsa052190.52990189
74beta-Alanine metabolism_Homo sapiens_hsa004100.52549253
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52106686
76Antigen processing and presentation_Homo sapiens_hsa046120.51832316
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.50444980
78Hepatitis C_Homo sapiens_hsa051600.49190187
79Metabolic pathways_Homo sapiens_hsa011000.48578480
80Cardiac muscle contraction_Homo sapiens_hsa042600.46833958
81Gastric acid secretion_Homo sapiens_hsa049710.46440399
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46223347
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46078089
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44362547
85Leishmaniasis_Homo sapiens_hsa051400.42369992
86Fatty acid biosynthesis_Homo sapiens_hsa000610.40843680
87Thyroid cancer_Homo sapiens_hsa052160.38179976
88Renin secretion_Homo sapiens_hsa049240.37930200
89Fatty acid metabolism_Homo sapiens_hsa012120.32525024
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.31795066
91Salmonella infection_Homo sapiens_hsa051320.31199749
92Selenocompound metabolism_Homo sapiens_hsa004500.31188087
93Ether lipid metabolism_Homo sapiens_hsa005650.29832088
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.29055296
95Salivary secretion_Homo sapiens_hsa049700.27726607
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25831255
97Other glycan degradation_Homo sapiens_hsa005110.25574630
98Biosynthesis of amino acids_Homo sapiens_hsa012300.24333159
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23561985
100Viral myocarditis_Homo sapiens_hsa054160.23356412
101Insulin resistance_Homo sapiens_hsa049310.23190190
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21671861
103African trypanosomiasis_Homo sapiens_hsa051430.20357116
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.20192954
105Vibrio cholerae infection_Homo sapiens_hsa051100.20161864
106Tyrosine metabolism_Homo sapiens_hsa003500.20152809
107Purine metabolism_Homo sapiens_hsa002300.19908707
108Propanoate metabolism_Homo sapiens_hsa006400.19728189
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19049702
110Adherens junction_Homo sapiens_hsa045200.17967799
111Peroxisome_Homo sapiens_hsa041460.16260012
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16038743
113GnRH signaling pathway_Homo sapiens_hsa049120.15878852
114Type II diabetes mellitus_Homo sapiens_hsa049300.14103687
115Toxoplasmosis_Homo sapiens_hsa051450.13193964
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12634636
117Influenza A_Homo sapiens_hsa051640.12267323
118Pertussis_Homo sapiens_hsa051330.11568006
119Steroid biosynthesis_Homo sapiens_hsa001000.11523202
120N-Glycan biosynthesis_Homo sapiens_hsa005100.11340509
121Sulfur relay system_Homo sapiens_hsa041220.11018199
122Insulin secretion_Homo sapiens_hsa049110.10874763
123Hematopoietic cell lineage_Homo sapiens_hsa046400.10360977
124Cocaine addiction_Homo sapiens_hsa050300.10029105
125Lysine degradation_Homo sapiens_hsa003100.07186400
126Serotonergic synapse_Homo sapiens_hsa047260.05997494
127Tuberculosis_Homo sapiens_hsa051520.04235969
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.03785158
129Rheumatoid arthritis_Homo sapiens_hsa053230.03218416
130Glucagon signaling pathway_Homo sapiens_hsa049220.02395986
131Ovarian steroidogenesis_Homo sapiens_hsa049130.00603434

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