TM4SF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)7.91846343
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.46689510
3regulation of protein activation cascade (GO:2000257)7.40329036
4complement activation, alternative pathway (GO:0006957)7.20395219
5regulation of complement activation (GO:0030449)7.04701794
6negative regulation of fibrinolysis (GO:0051918)7.03312941
7flavonoid metabolic process (GO:0009812)6.94097274
8protein carboxylation (GO:0018214)6.85632200
9peptidyl-glutamic acid carboxylation (GO:0017187)6.85632200
10regulation of fibrinolysis (GO:0051917)6.85300531
11adhesion of symbiont to host cell (GO:0044650)6.61984132
12virion attachment to host cell (GO:0019062)6.61984132
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.21496372
14L-phenylalanine catabolic process (GO:0006559)6.21496372
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20303529
16phospholipid efflux (GO:0033700)5.95617932
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.88957607
18L-phenylalanine metabolic process (GO:0006558)5.88957607
19positive regulation of lipoprotein lipase activity (GO:0051006)5.85385890
20positive regulation of triglyceride lipase activity (GO:0061365)5.85385890
21regulation of cholesterol esterification (GO:0010872)5.72691054
22regulation of triglyceride catabolic process (GO:0010896)5.70390283
23digestive system process (GO:0022600)5.68473222
24actin filament depolymerization (GO:0030042)5.51616762
25plasma lipoprotein particle assembly (GO:0034377)5.48281009
26drug catabolic process (GO:0042737)5.43297074
27epoxygenase P450 pathway (GO:0019373)5.43269651
28glyoxylate metabolic process (GO:0046487)5.42578457
29blood coagulation, intrinsic pathway (GO:0007597)5.32899849
30adhesion of symbiont to host (GO:0044406)5.32776245
31regulation of plasminogen activation (GO:0010755)5.22186580
32protein-lipid complex assembly (GO:0065005)5.17820066
33low-density lipoprotein particle remodeling (GO:0034374)5.12399656
34modified amino acid transport (GO:0072337)4.99180056
35fibrinolysis (GO:0042730)4.83551538
36hormone catabolic process (GO:0042447)4.81235465
37lipoprotein metabolic process (GO:0042157)4.80575942
38cholesterol efflux (GO:0033344)4.77503075
39purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.73126066
403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.73126066
41plasma lipoprotein particle clearance (GO:0034381)4.64897914
42very-low-density lipoprotein particle assembly (GO:0034379)4.64309396
43peptide catabolic process (GO:0043171)4.61550967
44digestion (GO:0007586)4.51828513
45phenylpropanoid metabolic process (GO:0009698)4.51520812
46acylglycerol homeostasis (GO:0055090)4.49719339
47triglyceride homeostasis (GO:0070328)4.49719339
48diacylglycerol metabolic process (GO:0046339)4.49375962
49NADH metabolic process (GO:0006734)4.48780429
50negative regulation of protein activation cascade (GO:2000258)4.41587267
51acute-phase response (GO:0006953)4.41333152
52glucose 6-phosphate metabolic process (GO:0051156)4.40750275
53protein activation cascade (GO:0072376)4.39348896
54negative regulation of blood coagulation (GO:0030195)4.35156387
55negative regulation of hemostasis (GO:1900047)4.35156387
56bundle of His cell to Purkinje myocyte communication (GO:0086069)4.30299340
57purine nucleotide salvage (GO:0032261)4.28470213
58negative regulation of lipase activity (GO:0060192)4.28460601
59regulation of humoral immune response (GO:0002920)4.27937971
60proline metabolic process (GO:0006560)4.24594641
61drinking behavior (GO:0042756)4.21469246
62positive regulation of fatty acid biosynthetic process (GO:0045723)4.18263912
63complement activation, classical pathway (GO:0006958)4.17666998
64bile acid metabolic process (GO:0008206)4.17114195
65peptide hormone processing (GO:0016486)4.11270659
66exogenous drug catabolic process (GO:0042738)4.08399256
67response to hepatocyte growth factor (GO:0035728)4.05794928
68cellular response to hepatocyte growth factor stimulus (GO:0035729)4.05794928
69regulation of apoptotic cell clearance (GO:2000425)4.02384521
70transepithelial transport (GO:0070633)4.01109227
71negative regulation of coagulation (GO:0050819)4.00803190
72negative regulation of sterol transport (GO:0032372)4.00362543
73negative regulation of cholesterol transport (GO:0032375)4.00362543
74reverse cholesterol transport (GO:0043691)3.98920914
75sterol transport (GO:0015918)3.98765045
76cholesterol transport (GO:0030301)3.98765045
77cholesterol homeostasis (GO:0042632)3.97983846
78negative regulation of wound healing (GO:0061045)3.96855562
79aromatic amino acid family catabolic process (GO:0009074)3.95151826
80regulation of bile acid biosynthetic process (GO:0070857)3.94908316
81sterol homeostasis (GO:0055092)3.94622454
82complement activation (GO:0006956)3.94340981
83ethanol oxidation (GO:0006069)3.91985285
84oligosaccharide catabolic process (GO:0009313)3.84469096
85lipoprotein transport (GO:0042953)3.83316911
86bile acid biosynthetic process (GO:0006699)3.79483613
87sulfation (GO:0051923)3.78124016
88serine family amino acid catabolic process (GO:0009071)3.75689970
89bile acid and bile salt transport (GO:0015721)3.74880173
90arginine metabolic process (GO:0006525)3.73823053
91omega-hydroxylase P450 pathway (GO:0097267)3.72835747
92positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.70607892
93response to hydroperoxide (GO:0033194)3.69050642
94UDP-N-acetylglucosamine metabolic process (GO:0006047)3.68309705
95intestinal epithelial cell development (GO:0060576)3.64836004
96positive regulation of steroid metabolic process (GO:0045940)3.63204215
97negative regulation of complement activation (GO:0045916)3.62136979
98positive regulation of blood coagulation (GO:0030194)3.62061792
99positive regulation of hemostasis (GO:1900048)3.62061792
100glutamate metabolic process (GO:0006536)3.62061481
101sulfate transmembrane transport (GO:1902358)3.60707119
102regulation of digestive system process (GO:0044058)3.54805447
103positive regulation of triglyceride metabolic process (GO:0090208)3.53155258
104urea metabolic process (GO:0019627)3.52721104
105urea cycle (GO:0000050)3.52721104
106regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.51418564
107cytolysis (GO:0019835)3.50530783
108fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49510220
109acute inflammatory response (GO:0002526)3.49331650
110cytidine deamination (GO:0009972)3.47752751
111cytidine metabolic process (GO:0046087)3.47752751
112cytidine catabolic process (GO:0006216)3.47752751
113high-density lipoprotein particle remodeling (GO:0034375)3.45386447
114glutamine family amino acid biosynthetic process (GO:0009084)3.42331765
115sulfur compound transport (GO:0072348)3.38904997
116oxidative demethylation (GO:0070989)3.37829661
117plasma lipoprotein particle organization (GO:0071827)3.37085840
118regulation of lipoprotein particle clearance (GO:0010984)3.36707546
119activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.35111654
120lipid homeostasis (GO:0055088)3.34624241
121protein-lipid complex remodeling (GO:0034368)3.33643815
122macromolecular complex remodeling (GO:0034367)3.33643815
123plasma lipoprotein particle remodeling (GO:0034369)3.33643815
124protein-lipid complex subunit organization (GO:0071825)3.33024336
125innate immune response in mucosa (GO:0002227)3.32934883
126bicarbonate transport (GO:0015701)3.32135281
127sperm capacitation (GO:0048240)3.31374478
128polyol transport (GO:0015791)3.29267760
129negative regulation of digestive system process (GO:0060457)3.28703239
130phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.28102836
131regulation of systemic arterial blood pressure by hormone (GO:0001990)3.27823949
132regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.27823949
133endocrine process (GO:0050886)3.27823949
134response to phenylpropanoid (GO:0080184)3.27384783
135positive regulation of T cell differentiation in thymus (GO:0033089)3.27017373
136cellular glucuronidation (GO:0052695)3.25922555
137drug metabolic process (GO:0017144)3.25668818
138sphingomyelin metabolic process (GO:0006684)3.24288983
139regulation of lipoprotein metabolic process (GO:0050746)3.22243193
140regulation of Golgi to plasma membrane protein transport (GO:0042996)3.20816271
141regulation of cholesterol homeostasis (GO:2000188)3.19559042
142drug transport (GO:0015893)3.18241952
143nitrogen cycle metabolic process (GO:0071941)3.16685801
144calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.16204892
145thyroid hormone metabolic process (GO:0042403)3.15250783
146membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.11089498
147regulation of cellular extravasation (GO:0002691)3.07486041
148cellular carbohydrate catabolic process (GO:0044275)3.07224117
149fructose metabolic process (GO:0006000)3.06503423
150uronic acid metabolic process (GO:0006063)3.06270446
151glucuronate metabolic process (GO:0019585)3.06270446
152positive regulation of lipid catabolic process (GO:0050996)3.05051701
153intestinal absorption (GO:0050892)13.0711356
154intestinal cholesterol absorption (GO:0030299)11.8226157
155angiotensin maturation (GO:0002003)11.1399323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.87747482
2FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.20538020
3HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.91659462
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.88873188
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.42843604
6GATA4_25053715_ChIP-Seq_YYC3_Human3.41177447
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36213153
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.02731807
9GATA6_25053715_ChIP-Seq_YYC3_Human3.01654905
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.91382820
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.68138517
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66003804
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.65374247
14SOX2_20726797_ChIP-Seq_SW620_Human2.64969323
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.47980180
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.39746296
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15779652
18* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.04550049
19TP63_17297297_ChIP-ChIP_HaCaT_Human10.1373880
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95070544
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.94815317
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85757629
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85101568
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81410138
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80843821
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78303961
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77614178
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74245983
29KLF5_25053715_ChIP-Seq_YYC3_Human1.67968359
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65162647
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54303633
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51756865
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.50994288
34RACK7_27058665_Chip-Seq_MCF-7_Human1.50882236
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48744554
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48454077
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48401637
38ATF3_27146783_Chip-Seq_COLON_Human1.46977905
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45783074
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44440014
41GATA1_22025678_ChIP-Seq_K562_Human1.42397212
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40629506
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40352309
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38651393
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.38183740
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37110983
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34392545
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.32551600
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31255066
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30201391
51* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28497891
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25293348
53AR_21909140_ChIP-Seq_LNCAP_Human1.24984129
54ZNF263_19887448_ChIP-Seq_K562_Human1.24500619
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24145337
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.23341078
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.21725237
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19943077
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19830822
60GATA2_19941826_ChIP-Seq_K562_Human1.19184771
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15228896
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14538021
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14409683
64LXR_22292898_ChIP-Seq_THP-1_Human1.11894075
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10361444
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10093315
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09953103
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09922963
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09591603
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09337621
71CLOCK_20551151_ChIP-Seq_293T_Human1.08997667
72CREB1_26743006_Chip-Seq_LNCaP_Human1.07814785
73BCL6_27268052_Chip-Seq_Bcells_Human1.06135040
74BCOR_27268052_Chip-Seq_Bcells_Human1.05707411
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04692393
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04085575
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03115429
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01795658
79NANOG_20526341_ChIP-Seq_ESCs_Human1.01128588
80PHF8_20622854_ChIP-Seq_HELA_Human0.99811592
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97092986
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95561047
83FOXA2_19822575_ChIP-Seq_HepG2_Human0.94691211
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94544547
85ERG_21242973_ChIP-ChIP_JURKAT_Human0.94169368
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94077514
87RARA_24833708_ChIP-Seq_LIVER_Mouse0.93444174
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92476285
89TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90842494
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90813715
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90621445
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88058074
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87838170
94P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87291196
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87227468
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86170998
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86170553
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86154139
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85734045
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85051061
101* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84632749
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83001008
103E2F1_20622854_ChIP-Seq_HELA_Human0.82278623
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82202167
105TP63_22573176_ChIP-Seq_HFKS_Human0.82039952
106TET1_21451524_ChIP-Seq_MESCs_Mouse0.81848752
107GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81705205
108SA1_27219007_Chip-Seq_Bcells_Human0.81608330
109GATA1_26923725_Chip-Seq_HPCs_Mouse0.81502777
110CTCF_27219007_Chip-Seq_Bcells_Human0.80632678
111ELF5_23300383_ChIP-Seq_T47D_Human0.79850949
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79207520
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79050836
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.78818040
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78595914
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78595914
117NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78542395
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78530524
119* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78020024
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.76724287
121MYC_19829295_ChIP-Seq_ESCs_Human0.76582859
122SMC4_20622854_ChIP-Seq_HELA_Human0.76144061
123P68_20966046_ChIP-Seq_HELA_Human0.75690419
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.75658623
125GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75509328
126SOX2_21211035_ChIP-Seq_LN229_Human0.75373779
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75292619
128P300_27268052_Chip-Seq_Bcells_Human0.75117268
129NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75013267
130RAC3_21632823_ChIP-Seq_H3396_Human0.74432469
131* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74216893
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73595741
133STAT1_20625510_ChIP-Seq_HELA_Human0.72662672
134CEBPB_22108803_ChIP-Seq_LS180_Human0.71580935
135* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70078943
136* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.69355447
137RARB_24833708_ChIP-Seq_LIVER_Mouse0.68788891
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.67702892
139NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.67304861
140MYC_19915707_ChIP-ChIP_AK7_Human0.66367636
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64846341
142* CTCF_20526341_ChIP-Seq_ESCs_Human0.64771047
143POU5F1_16518401_ChIP-PET_MESCs_Mouse0.64238221
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.63995346
145SOX2_22085726_ChIP-Seq_NPCs_Mouse0.63478980
146HTT_18923047_ChIP-ChIP_STHdh_Human0.62701399
147ERA_21632823_ChIP-Seq_H3396_Human0.59968059
148STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.59910586
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.58940986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.72698132
2MP0001666_abnormal_nutrient_absorption5.93680088
3MP0009840_abnormal_foam_cell4.44564544
4MP0003195_calcinosis4.37210748
5MP0002139_abnormal_hepatobiliary_system3.90153542
6MP0003183_abnormal_peptide_metabolism3.76621358
7MP0010234_abnormal_vibrissa_follicle3.60425985
8MP0004264_abnormal_extraembryonic_tissu3.57260053
9MP0003868_abnormal_feces_composition3.35209057
10MP0000462_abnormal_digestive_system3.16964806
11MP0003252_abnormal_bile_duct2.97074498
12MP0008875_abnormal_xenobiotic_pharmacok2.93862713
13MP0005085_abnormal_gallbladder_physiolo2.72098555
14MP0003866_abnormal_defecation2.64403731
15MP0010329_abnormal_lipoprotein_level2.58147657
16MP0002254_reproductive_system_inflammat2.40618468
17MP0010352_gastrointestinal_tract_polyps2.36557807
18MP0001873_stomach_inflammation2.31705757
19MP0004019_abnormal_vitamin_homeostasis2.21760197
20MP0010155_abnormal_intestine_physiology2.00192664
21MP0001663_abnormal_digestive_system1.99797219
22MP0005381_digestive/alimentary_phenotyp1.88967772
23MP0000537_abnormal_urethra_morphology1.86116651
24MP0000490_abnormal_crypts_of1.84902072
25MP0009379_abnormal_foot_pigmentation1.83866559
26MP0005084_abnormal_gallbladder_morpholo1.74285312
27MP0004147_increased_porphyrin_level1.73013191
28MP0002822_catalepsy1.72317446
29MP0001664_abnormal_digestion1.69389003
30MP0003300_gastrointestinal_ulcer1.66258116
31MP0000477_abnormal_intestine_morphology1.58923522
32MP0005058_abnormal_lysosome_morphology1.58285612
33MP0009697_abnormal_copulation1.56867182
34MP0004043_abnormal_pH_regulation1.53244210
35MP0000538_abnormal_urinary_bladder1.50533726
36MP0005377_hearing/vestibular/ear_phenot1.49948536
37MP0003878_abnormal_ear_physiology1.49948536
38MP0005408_hypopigmentation1.49913710
39MP0003705_abnormal_hypodermis_morpholog1.43098578
40MP0003122_maternal_imprinting1.41875648
41MP0005448_abnormal_energy_balance1.39300748
42MP0002796_impaired_skin_barrier1.34090864
43MP0005332_abnormal_amino_acid1.29143201
44MP0003806_abnormal_nucleotide_metabolis1.28874596
45MP0005365_abnormal_bile_salt1.26385674
46MP0002089_abnormal_postnatal_growth/wei1.23984713
47MP0003191_abnormal_cellular_cholesterol1.20603285
48MP0009643_abnormal_urine_homeostasis1.18593393
49MP0000566_synostosis1.18286580
50MP0003718_maternal_effect1.15020702
51MP0008004_abnormal_stomach_pH1.09956216
52MP0008872_abnormal_physiological_respon1.07597440
53MP0003693_abnormal_embryo_hatching1.05169833
54MP0006054_spinal_hemorrhage1.03405077
55MP0000598_abnormal_liver_morphology1.02081437
56MP0005409_darkened_coat_color0.97406103
57MP0000609_abnormal_liver_physiology0.93968262
58MP0002132_abnormal_respiratory_system0.93889485
59MP0001915_intracranial_hemorrhage0.92712217
60MP0002876_abnormal_thyroid_physiology0.92485647
61MP0005670_abnormal_white_adipose0.91493492
62MP0002118_abnormal_lipid_homeostasis0.90699856
63MP0005464_abnormal_platelet_physiology0.87949489
64MP0005266_abnormal_metabolism0.85539079
65MP0003172_abnormal_lysosome_physiology0.84900928
66MP0004947_skin_inflammation0.84351410
67MP0002098_abnormal_vibrissa_morphology0.81209147
68MP0001849_ear_inflammation0.79496441
69MP0002971_abnormal_brown_adipose0.79092471
70MP0000467_abnormal_esophagus_morphology0.76875213
71MP0003123_paternal_imprinting0.76815011
72MP0005501_abnormal_skin_physiology0.76400168
73MP0001661_extended_life_span0.75269874
74MP0001764_abnormal_homeostasis0.74730087
75MP0003453_abnormal_keratinocyte_physiol0.73814655
76MP0002277_abnormal_respiratory_mucosa0.72947583
77MP0010368_abnormal_lymphatic_system0.71608711
78MP0000470_abnormal_stomach_morphology0.70607090
79MP0002078_abnormal_glucose_homeostasis0.69931527
80MP0005319_abnormal_enzyme/_coenzyme0.68839778
81MP0002136_abnormal_kidney_physiology0.68652234
82MP0005367_renal/urinary_system_phenotyp0.68643088
83MP0000516_abnormal_urinary_system0.68643088
84MP0005310_abnormal_salivary_gland0.67786312
85MP0009765_abnormal_xenobiotic_induced0.65745747
86MP0003283_abnormal_digestive_organ0.65661078
87MP0000678_abnormal_parathyroid_gland0.65250599
88MP0001756_abnormal_urination0.64819180
89MP0010678_abnormal_skin_adnexa0.64240210
90MP0005395_other_phenotype0.63526108
91MP0005166_decreased_susceptibility_to0.61202278
92MP0003315_abnormal_perineum_morphology0.60683977
93MP0009053_abnormal_anal_canal0.60601427
94MP0001765_abnormal_ion_homeostasis0.60062120
95MP0009333_abnormal_splenocyte_physiolog0.59689561
96MP0005451_abnormal_body_composition0.59258178
97MP0005636_abnormal_mineral_homeostasis0.58380976
98MP0000249_abnormal_blood_vessel0.58188758
99MP0004270_analgesia0.56314715
100MP0003879_abnormal_hair_cell0.55862826
101MP0005376_homeostasis/metabolism_phenot0.55185516
102MP0001216_abnormal_epidermal_layer0.54937884
103MP0000613_abnormal_salivary_gland0.54598009
104MP0002138_abnormal_hepatobiliary_system0.54050127
105MP0003638_abnormal_response/metabolism_0.53862447
106MP0002148_abnormal_hypersensitivity_rea0.53805411
107MP0005083_abnormal_biliary_tract0.53107131
108MP0005167_abnormal_blood-brain_barrier0.51693236
109MP0003186_abnormal_redox_activity0.51494526
110MP0009763_increased_sensitivity_to0.51306930
111MP0009642_abnormal_blood_homeostasis0.51099893
112MP0003953_abnormal_hormone_level0.50376346
113MP0001845_abnormal_inflammatory_respons0.49480486
114MP0001485_abnormal_pinna_reflex0.48536917
115MP0005584_abnormal_enzyme/coenzyme_acti0.48191890
116MP0003119_abnormal_digestive_system0.48011831
117MP0003941_abnormal_skin_development0.47961962
118MP0003329_amyloid_beta_deposits0.46321600
119MP0000003_abnormal_adipose_tissue0.46229143
120MP0001881_abnormal_mammary_gland0.45835424
121MP0004272_abnormal_basement_membrane0.44741034
122MP0009115_abnormal_fat_cell0.44722740
123MP0003011_delayed_dark_adaptation0.44186398
124MP0001191_abnormal_skin_condition0.43758599
125MP0005164_abnormal_response_to0.43592446
126MP0005535_abnormal_body_temperature0.42937140
127MP0008469_abnormal_protein_level0.42438766
128MP0003656_abnormal_erythrocyte_physiolo0.41879828
129MP0005174_abnormal_tail_pigmentation0.40870597
130MP0005334_abnormal_fat_pad0.39018276
131MP0000639_abnormal_adrenal_gland0.38973860
132MP0009384_cardiac_valve_regurgitation0.38472468
133MP0000604_amyloidosis0.37718902
134MP0005410_abnormal_fertilization0.36930391
135MP0005257_abnormal_intraocular_pressure0.36780705
136MP0002970_abnormal_white_adipose0.36627481
137MP0009764_decreased_sensitivity_to0.34613338
138MP0002909_abnormal_adrenal_gland0.33929260
139MP0005187_abnormal_penis_morphology0.31270840
140MP0002168_other_aberrant_phenotype0.30422659
141MP0003567_abnormal_fetal_cardiomyocyte0.30166732
142MP0004883_abnormal_blood_vessel0.29563257
143MP0002090_abnormal_vision0.29395039
144MP0000920_abnormal_myelination0.29122974
145MP0008260_abnormal_autophagy0.29121459
146MP0005220_abnormal_exocrine_pancreas0.28932354
147MP0003690_abnormal_glial_cell0.28242173
148MP0005023_abnormal_wound_healing0.27571972
149MP0009780_abnormal_chondrocyte_physiolo0.27429879
150MP0005666_abnormal_adipose_tissue0.27325255

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.40837135
2Prolonged partial thromboplastin time (HP:0003645)7.76838339
3Abnormality of glutamine family amino acid metabolism (HP:0010902)7.21794010
4Complement deficiency (HP:0004431)6.97066254
5Hypobetalipoproteinemia (HP:0003563)6.88153688
6Acanthocytosis (HP:0001927)6.62673558
7Autoimmune thrombocytopenia (HP:0001973)6.32303132
8Joint hemorrhage (HP:0005261)6.17062040
9Malnutrition (HP:0004395)6.02899816
10Abnormality of aromatic amino acid family metabolism (HP:0004338)6.00230902
11Systemic lupus erythematosus (HP:0002725)5.87665601
12Abnormality of complement system (HP:0005339)5.49327063
13Abnormality of proline metabolism (HP:0010907)5.43829780
14Hydroxyprolinuria (HP:0003080)5.43829780
15Glomerulonephritis (HP:0000099)5.18131972
16Abnormality of the common coagulation pathway (HP:0010990)4.92020106
17Autoimmune hemolytic anemia (HP:0001890)4.70829388
18Right ventricular cardiomyopathy (HP:0011663)4.56669598
19Spontaneous abortion (HP:0005268)4.37226081
20Conjugated hyperbilirubinemia (HP:0002908)4.34510166
21Cupped ribs (HP:0000887)4.26820309
22Pigmentary retinal degeneration (HP:0001146)4.12034597
23Hyperlipoproteinemia (HP:0010980)4.09499693
24Widely patent fontanelles and sutures (HP:0004492)3.91119188
25Abnormality of urine glucose concentration (HP:0011016)3.87431270
26Glycosuria (HP:0003076)3.87431270
27Poikilocytosis (HP:0004447)3.86953321
28Hemorrhage of the eye (HP:0011885)3.80297742
29Increased IgE level (HP:0003212)3.73910997
30Fat malabsorption (HP:0002630)3.73298638
31Hypolipoproteinemia (HP:0010981)3.70326735
32Abnormality of pyrimidine metabolism (HP:0004353)3.69857727
33Mesangial abnormality (HP:0001966)3.61476300
34Hyperglycinuria (HP:0003108)3.58768998
35Abdominal distention (HP:0003270)3.45778967
36Menorrhagia (HP:0000132)3.33600159
37Gingival bleeding (HP:0000225)3.25467412
38Chronic diarrhea (HP:0002028)3.23790726
39Severe combined immunodeficiency (HP:0004430)3.19101130
40Facial shape deformation (HP:0011334)3.17978749
41Potter facies (HP:0002009)3.17978749
42Nephritis (HP:0000123)3.16309578
43Vascular calcification (HP:0004934)3.14269750
44Hypoalphalipoproteinemia (HP:0003233)3.11676358
45Abnormality of B cell number (HP:0010975)3.10767927
46B lymphocytopenia (HP:0010976)3.10767927
47Combined immunodeficiency (HP:0005387)3.04651542
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.94651366
49Gastrointestinal dysmotility (HP:0002579)2.93841698
50Hyperphosphaturia (HP:0003109)2.93760702
51Purpura (HP:0000979)2.91457119
52Congenital sensorineural hearing impairment (HP:0008527)2.91030484
53Hyperglycinemia (HP:0002154)2.80950816
54Wide cranial sutures (HP:0010537)2.80589357
55Dehydration (HP:0001944)2.77864669
56Villous atrophy (HP:0011473)2.76511487
57Abnormality of small intestinal villus morphology (HP:0011472)2.76511487
58Ventricular fibrillation (HP:0001663)2.74877238
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74204894
60Cardiovascular calcification (HP:0011915)2.73424837
61Generalized aminoaciduria (HP:0002909)2.72834624
62Abnormality of vitamin B metabolism (HP:0004340)2.71174544
63Nausea (HP:0002018)2.70206405
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68407239
65Nephrolithiasis (HP:0000787)2.67991125
66Xanthomatosis (HP:0000991)2.67769284
67Reticulocytosis (HP:0001923)2.65424630
68Rectal prolapse (HP:0002035)2.63849377
69Abnormal glucose tolerance (HP:0001952)2.62770576
70Abnormality of purine metabolism (HP:0004352)2.61347543
71Hepatocellular carcinoma (HP:0001402)2.60615038
72Hypercholesterolemia (HP:0003124)2.56202410
73Abnormality of the intrinsic pathway (HP:0010989)2.53501614
74Increased mean platelet volume (HP:0011877)2.52230680
75Gout (HP:0001997)2.49918983
76Mitral stenosis (HP:0001718)2.48235045
77Thyroiditis (HP:0100646)2.47960805
78Proximal tubulopathy (HP:0000114)2.46340503
79Steatorrhea (HP:0002570)2.46145738
80Abnormal urine phosphate concentration (HP:0012599)2.44376096
81Delayed CNS myelination (HP:0002188)2.44192495
82Abnormality of the gastric mucosa (HP:0004295)2.44017188
83Abnormality of the Achilles tendon (HP:0005109)2.42866344
84Recurrent gram-negative bacterial infections (HP:0005420)2.42782835
85Thrombophlebitis (HP:0004418)2.42559961
86Abnormality of serine family amino acid metabolism (HP:0010894)2.40899602
87Abnormality of glycine metabolism (HP:0010895)2.40899602
88Palpitations (HP:0001962)2.38758360
89Hypophosphatemic rickets (HP:0004912)2.38149794
90Osteomalacia (HP:0002749)2.37340162
91Pustule (HP:0200039)2.36461060
92Rickets (HP:0002748)2.33769585
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33479104
94Cheilitis (HP:0100825)2.30855525
95Abnormality of vitamin metabolism (HP:0100508)2.30813455
96Enlarged kidneys (HP:0000105)2.29737974
97Abnormality of carpal bone ossification (HP:0006257)2.26573273
98Abnormal biliary tract morphology (HP:0012440)2.26137999
99Thin bony cortex (HP:0002753)2.24673110
100Abnormal tarsal ossification (HP:0008369)2.23219423
101Metabolic acidosis (HP:0001942)2.23173051
102Woolly hair (HP:0002224)2.20020631
103Confusion (HP:0001289)2.19642514
104Hyperammonemia (HP:0001987)2.18665779
105Pili torti (HP:0003777)2.17803440
106Abnormality of nucleobase metabolism (HP:0010932)2.16434991
107Abnormal platelet volume (HP:0011876)2.16013901
108Hyperparathyroidism (HP:0000843)2.14727883
109Syncope (HP:0001279)2.12136682
110Late onset (HP:0003584)2.11657757
111Intrahepatic cholestasis (HP:0001406)2.11602748
112Polycythemia (HP:0001901)2.10921414
113Abnormality of serum amino acid levels (HP:0003112)2.09325190
114Arthropathy (HP:0003040)2.08637405
115Reduced antithrombin III activity (HP:0001976)2.06334617
116Retinal atrophy (HP:0001105)2.05432584
117Myocardial infarction (HP:0001658)2.04409486
118Abnormality of sulfur amino acid metabolism (HP:0004339)2.04167856
119Megaloblastic anemia (HP:0001889)2.04000071
120Deep venous thrombosis (HP:0002625)10.1002363
121Amyloidosis (HP:0011034)1.98121697
122Pulmonary embolism (HP:0002204)1.97270166
123Skin nodule (HP:0200036)1.96840433
124Abnormality of eosinophils (HP:0001879)1.95649335
125Symptomatic seizures (HP:0011145)1.95338882
126Eosinophilia (HP:0001880)1.95154139
127Hypoalbuminemia (HP:0003073)1.94506599
128Abnormal albumin level (HP:0012116)1.94506599
129Epidermoid cyst (HP:0200040)1.93598465
130Hypophosphatemia (HP:0002148)1.92103457
131Abnormality of reticulocytes (HP:0004312)1.91534283
132Abnormal gallbladder physiology (HP:0012438)1.87261948
133Cholecystitis (HP:0001082)1.87261948
134Mucopolysacchariduria (HP:0008155)1.85911767
135Urinary glycosaminoglycan excretion (HP:0003541)1.85911767
136Hypoglycemic coma (HP:0001325)1.85391630
137Increased serum pyruvate (HP:0003542)1.84999212
138Granulocytopenia (HP:0001913)1.83958558
139Abnormality of chloride homeostasis (HP:0011422)1.82177655
140Flat acetabular roof (HP:0003180)1.81869506
141Gingivitis (HP:0000230)1.81167609
142Joint swelling (HP:0001386)1.80462698
143Increased serum ferritin (HP:0003281)1.80192960
144Myopathic facies (HP:0002058)1.80159774
145Hyperuricemia (HP:0002149)1.80013628
146Increased purine levels (HP:0004368)1.80013628
147Delayed epiphyseal ossification (HP:0002663)1.79816287
148Irritability (HP:0000737)1.79329863
149Alkalosis (HP:0001948)1.79014664
150Hyperbilirubinemia (HP:0002904)1.76346380
151Mildly elevated creatine phosphokinase (HP:0008180)1.75012139
152Abnormality of alkaline phosphatase activity (HP:0004379)1.74629416
153Posterior subcapsular cataract (HP:0007787)1.73873715
154Ketoacidosis (HP:0001993)1.73573000
155Abnormal enzyme/coenzyme activity (HP:0012379)1.72877827
156Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70362575
157Abnormality of polysaccharide metabolism (HP:0011012)1.70362575
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70362575
159Polygenic inheritance (HP:0010982)1.69290727
160Micronodular cirrhosis (HP:0001413)1.68336603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.45365101
2MST45.26842867
3FRK5.18900749
4MST1R4.28229677
5NME14.02764680
6PRKG23.62403529
7GRK63.59236303
8FGFR33.49137586
9MAP2K22.85098700
10NTRK32.71826699
11AKT32.28549622
12ACVR1B2.26526954
13EPHA22.25215458
14MAP3K102.23272260
15MAP3K22.21667892
16NUAK12.09103902
17TRIB32.04472430
18RIPK12.03847114
19PTK62.03652106
20PIK3CA1.98762064
21SIK11.95592354
22EPHB21.70184203
23ERN11.68333873
24PBK1.67543999
25MAP2K61.65996176
26TESK11.53855977
27PDGFRA1.47390852
28TESK21.42665479
29MET1.37124064
30MAP3K111.33428956
31EPHA41.27854918
32TYRO31.26793054
33MAP3K81.25729688
34STK101.25004985
35PRKCI1.22746235
36FGFR21.21375467
37PIK3CG1.21190920
38PIM21.20499103
39TTK1.19059012
40FGFR11.17973322
41TAOK11.11020908
42PDK11.08970407
43KSR21.04535788
44TBK11.00603364
45BCKDK0.99756855
46BMX0.98544880
47TYK20.96002593
48IRAK30.95698029
49EPHB10.93043541
50SCYL20.87826987
51PAK40.87212686
52PTK20.85921825
53RET0.85028656
54MATK0.84544517
55PRKCG0.82354308
56SIK20.81253661
57TAOK30.80663805
58CDC42BPA0.79105352
59DDR20.75522242
60ERBB20.75266296
61MAP4K10.74862958
62RIPK40.72626196
63TGFBR20.72227064
64FER0.71435448
65PRKAA20.70796458
66MAP3K10.70729596
67LRRK20.68747780
68MAP3K30.68379921
69PRKCZ0.64898792
70MAP3K140.61878608
71MAP2K10.61747074
72MYLK0.60319894
73MAPKAPK30.60293954
74CSF1R0.59214205
75MAPK110.58943226
76DYRK1B0.58762297
77ABL20.57484455
78BLK0.57313277
79STK390.56203893
80ERBB40.55035539
81WNK10.51985977
82SGK4940.51530072
83SGK2230.51530072
84MUSK0.51298595
85IGF1R0.50921868
86LATS10.50226426
87CSNK1E0.48716740
88SGK10.48438393
89ARAF0.46373846
90PRKG10.46274767
91FGFR40.46180243
92MAP3K90.45633584
93PAK10.45414662
94FGR0.44653445
95MAP2K30.44447282
96MAP3K70.43968584
97PRKACA0.43589251
98FLT30.43587134
99PKN20.43107067
100AURKB0.42086858
101MAP2K40.41527882
102NME20.41209549
103ZAP700.40620317
104CSNK1D0.40275197
105GRK10.38362145
106NLK0.37713662
107CDK120.37583040
108WNK40.37110152
109CSNK2A20.36362810
110PRKCB0.36203818
111MAP3K120.35563778
112NEK90.35534097
113SMG10.35238561
114NEK10.34351809
115PRKCD0.33982346
116EEF2K0.33025393
117CSNK2A10.32616923
118CDK60.32461839
119CSK0.32374606
120PDPK10.30287571
121RPS6KB10.29902230
122PRKCA0.29316215
123PRKCQ0.28885044
124MAPKAPK20.28228645
125IKBKE0.27579779
126EIF2AK10.27543819
127MAP3K60.26341863
128MAPK30.25962367
129CAMK2G0.25605241
130ICK0.25265515
131RPS6KA30.25058469
132PRKAA10.24412727
133SRC0.24147444
134CSNK1A10.23606351
135LIMK10.23356302
136CHUK0.22656377
137CDK40.21037184
138PRKACG0.20711132
139AKT20.20703633
140BRAF0.20311978
141JAK20.19583345
142MELK0.19541611
143GSK3A0.18879376
144IRAK40.18818532
145MAP3K130.18776474
146PDK20.18581397
147CDK70.16437574
148OXSR10.14927141
149PAK30.14251499

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.16462716
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.61205343
3Complement and coagulation cascades_Homo sapiens_hsa046104.37062360
4Renin-angiotensin system_Homo sapiens_hsa046144.30020152
5Vitamin digestion and absorption_Homo sapiens_hsa049774.19920871
6Mineral absorption_Homo sapiens_hsa049783.95446136
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40036176
8Primary bile acid biosynthesis_Homo sapiens_hsa001203.20274361
9Galactose metabolism_Homo sapiens_hsa000522.88200090
10Starch and sucrose metabolism_Homo sapiens_hsa005002.73496795
11Folate biosynthesis_Homo sapiens_hsa007902.63157308
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63008724
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.61681745
14Caffeine metabolism_Homo sapiens_hsa002322.47067386
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43213522
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.25953810
17Protein digestion and absorption_Homo sapiens_hsa049742.20717005
18Fructose and mannose metabolism_Homo sapiens_hsa000512.16758939
19Histidine metabolism_Homo sapiens_hsa003401.97466136
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83340518
21Sulfur metabolism_Homo sapiens_hsa009201.82154036
22Glutathione metabolism_Homo sapiens_hsa004801.79623820
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.77837134
24Bile secretion_Homo sapiens_hsa049761.76250646
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.73649258
26Tyrosine metabolism_Homo sapiens_hsa003501.66451295
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55013254
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44522353
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40102549
30Staphylococcus aureus infection_Homo sapiens_hsa051501.37321707
31Tryptophan metabolism_Homo sapiens_hsa003801.36541509
32Glycerolipid metabolism_Homo sapiens_hsa005611.36272427
33Arginine biosynthesis_Homo sapiens_hsa002201.32898086
34Arginine and proline metabolism_Homo sapiens_hsa003301.27315685
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21262838
36Sphingolipid metabolism_Homo sapiens_hsa006001.20801223
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18077370
38Nitrogen metabolism_Homo sapiens_hsa009101.15407422
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14602367
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14320296
41Pentose phosphate pathway_Homo sapiens_hsa000301.13702250
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12830178
43PPAR signaling pathway_Homo sapiens_hsa033201.10483247
44Prion diseases_Homo sapiens_hsa050201.10313420
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08617525
46Fatty acid degradation_Homo sapiens_hsa000711.08373019
47Sulfur relay system_Homo sapiens_hsa041221.07756506
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.05617696
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97152149
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96704347
51Other glycan degradation_Homo sapiens_hsa005110.95581646
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95073262
53Pyruvate metabolism_Homo sapiens_hsa006200.94786322
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93476040
55Chemical carcinogenesis_Homo sapiens_hsa052040.87205165
56Carbon metabolism_Homo sapiens_hsa012000.85121606
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83483410
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.82841208
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.78215624
60Retinol metabolism_Homo sapiens_hsa008300.74807172
61ABC transporters_Homo sapiens_hsa020100.71595330
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.70305718
63Vitamin B6 metabolism_Homo sapiens_hsa007500.69017530
64Propanoate metabolism_Homo sapiens_hsa006400.64270122
65Biosynthesis of amino acids_Homo sapiens_hsa012300.59932283
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58796992
67beta-Alanine metabolism_Homo sapiens_hsa004100.57626236
68Arachidonic acid metabolism_Homo sapiens_hsa005900.55428929
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.54090652
70Thyroid hormone synthesis_Homo sapiens_hsa049180.53979158
71Tight junction_Homo sapiens_hsa045300.50055307
72Fatty acid elongation_Homo sapiens_hsa000620.47975979
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40562907
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38021026
75Linoleic acid metabolism_Homo sapiens_hsa005910.37391753
76Insulin resistance_Homo sapiens_hsa049310.36660464
77Metabolic pathways_Homo sapiens_hsa011000.33843277
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.33188807
79Hepatitis C_Homo sapiens_hsa051600.33065324
80One carbon pool by folate_Homo sapiens_hsa006700.32875327
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.32756126
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30604819
83Glucagon signaling pathway_Homo sapiens_hsa049220.30210304
84Pancreatic secretion_Homo sapiens_hsa049720.28974163
85Parkinsons disease_Homo sapiens_hsa050120.28160596
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27601640
87Oxidative phosphorylation_Homo sapiens_hsa001900.27196266
88Thyroid cancer_Homo sapiens_hsa052160.26849225
89African trypanosomiasis_Homo sapiens_hsa051430.26839645
90Alzheimers disease_Homo sapiens_hsa050100.26422271
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.26354730
92Peroxisome_Homo sapiens_hsa041460.25670839
93Type II diabetes mellitus_Homo sapiens_hsa049300.23277887
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23223806
95Selenocompound metabolism_Homo sapiens_hsa004500.22773185
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22611900
97Bladder cancer_Homo sapiens_hsa052190.22291176
98Salmonella infection_Homo sapiens_hsa051320.22087155
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21271957
100N-Glycan biosynthesis_Homo sapiens_hsa005100.20417730
101Gastric acid secretion_Homo sapiens_hsa049710.20281129
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20004186
103Fatty acid metabolism_Homo sapiens_hsa012120.19165821
104Ether lipid metabolism_Homo sapiens_hsa005650.16190721
105Fatty acid biosynthesis_Homo sapiens_hsa000610.16070498
106Steroid biosynthesis_Homo sapiens_hsa001000.15193055
107Butanoate metabolism_Homo sapiens_hsa006500.13717898
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11834493
109Lysine degradation_Homo sapiens_hsa003100.11404632
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11254639
111Legionellosis_Homo sapiens_hsa051340.09900511
112Huntingtons disease_Homo sapiens_hsa050160.07022450
113AMPK signaling pathway_Homo sapiens_hsa041520.04690084
114Vibrio cholerae infection_Homo sapiens_hsa051100.04384468
115Apoptosis_Homo sapiens_hsa042100.02664729
116Influenza A_Homo sapiens_hsa051640.02534628
117Adherens junction_Homo sapiens_hsa045200.01735000
118Pertussis_Homo sapiens_hsa051330.01654510
119Lysosome_Homo sapiens_hsa04142-0.1054458
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0836982
121Insulin signaling pathway_Homo sapiens_hsa04910-0.0778132
122Amoebiasis_Homo sapiens_hsa05146-0.0682075
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0517706
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0384781
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0364582
126TNF signaling pathway_Homo sapiens_hsa04668-0.0357005
127Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0223243
128GnRH signaling pathway_Homo sapiens_hsa04912-0.0126592
129Primary immunodeficiency_Homo sapiens_hsa05340-0.0094044
130Phenylalanine metabolism_Homo sapiens_hsa00360-0.0092691
131Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0020102

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