ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	angiotensin maturation (GO:0002003)	9.86170243
2	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	8.36980716
3	epoxygenase P450 pathway (GO:0019373)	7.88847806
4	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	7.11390627
5	regulation of guanylate cyclase activity (GO:0031282)	6.92972038
6	NADH metabolic process (GO:0006734)	6.90327792
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.64174624
8	L-phenylalanine catabolic process (GO:0006559)	6.64174624
9	fat-soluble vitamin biosynthetic process (GO:0042362)	6.58470847
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.39567264
11	L-phenylalanine metabolic process (GO:0006558)	6.39567264
12	hormone catabolic process (GO:0042447)	6.02518166
13	fructose metabolic process (GO:0006000)	5.90267513
14	high-density lipoprotein particle remodeling (GO:0034375)	5.89589785
15	aromatic amino acid family catabolic process (GO:0009074)	5.88309195
16	regulation of cholesterol esterification (GO:0010872)	5.79111536
17	lipoprotein transport (GO:0042953)	5.76946969
18	intestinal cholesterol absorption (GO:0030299)	5.76383223
19	urea metabolic process (GO:0019627)	5.55765285
20	urea cycle (GO:0000050)	5.55765285
21	regulation of triglyceride catabolic process (GO:0010896)	5.51616600
22	phospholipid efflux (GO:0033700)	5.47567561
23	reverse cholesterol transport (GO:0043691)	5.34632875
24	indole-containing compound catabolic process (GO:0042436)	5.22641158
25	indolalkylamine catabolic process (GO:0046218)	5.22641158
26	tryptophan catabolic process (GO:0006569)	5.22641158
27	positive regulation of guanylate cyclase activity (GO:0031284)	5.18658672
28	plasma lipoprotein particle remodeling (GO:0034369)	5.15590588
29	protein-lipid complex remodeling (GO:0034368)	5.15590588
30	macromolecular complex remodeling (GO:0034367)	5.15590588
31	kynurenine metabolic process (GO:0070189)	5.14834392
32	alpha-linolenic acid metabolic process (GO:0036109)	5.09942582
33	nitrogen cycle metabolic process (GO:0071941)	5.09626973
34	cysteine metabolic process (GO:0006534)	5.09582692
35	glyoxylate metabolic process (GO:0046487)	5.08098858
36	negative regulation of cholesterol transport (GO:0032375)	5.06100163
37	negative regulation of sterol transport (GO:0032372)	5.06100163
38	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	5.04243273
39	endocrine process (GO:0050886)	5.04243273
40	regulation of systemic arterial blood pressure by hormone (GO:0001990)	5.04243273
41	bile acid biosynthetic process (GO:0006699)	4.98965042
42	intestinal absorption (GO:0050892)	4.98828361
43	negative regulation of leukocyte chemotaxis (GO:0002689)	4.98196699
44	tryptophan metabolic process (GO:0006568)	4.91091283
45	cholesterol efflux (GO:0033344)	4.88576728
46	sulfur amino acid catabolic process (GO:0000098)	4.87110737
47	negative regulation of fibrinolysis (GO:0051918)	4.87000792
48	bile acid and bile salt transport (GO:0015721)	4.85452724
49	diacylglycerol metabolic process (GO:0046339)	4.85126644
50	plasma lipoprotein particle assembly (GO:0034377)	4.84676886
51	drug catabolic process (GO:0042737)	4.82585472
52	positive regulation of lipoprotein lipase activity (GO:0051006)	4.72070922
53	positive regulation of triglyceride lipase activity (GO:0061365)	4.72070922
54	triglyceride homeostasis (GO:0070328)	4.69023188
55	acylglycerol homeostasis (GO:0055090)	4.69023188
56	regulation of fibrinolysis (GO:0051917)	4.64908819
57	bile acid metabolic process (GO:0008206)	4.62482774
58	homocysteine metabolic process (GO:0050667)	4.62220768
59	peptidyl-glutamic acid carboxylation (GO:0017187)	4.59821649
60	protein carboxylation (GO:0018214)	4.59821649
61	regulation of systemic arterial blood pressure (GO:0003073)	4.51790464
62	flavonoid metabolic process (GO:0009812)	4.49538868
63	serine family amino acid catabolic process (GO:0009071)	4.48839682
64	plasma lipoprotein particle clearance (GO:0034381)	4.44073297
65	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.43001823
66	protein-lipid complex assembly (GO:0065005)	4.41283674
67	very-low-density lipoprotein particle assembly (GO:0034379)	4.35775276
68	regulation of protein activation cascade (GO:2000257)	4.33437717
69	regulation of cGMP biosynthetic process (GO:0030826)	4.30038360
70	alkaloid metabolic process (GO:0009820)	4.29999255
71	aromatic amino acid family metabolic process (GO:0009072)	4.27675756
72	regulation of bile acid biosynthetic process (GO:0070857)	4.27232997
73	complement activation, alternative pathway (GO:0006957)	4.26195254
74	renal system process involved in regulation of blood volume (GO:0001977)	4.26130710
75	amino-acid betaine metabolic process (GO:0006577)	4.24457780
76	cellular glucuronidation (GO:0052695)	4.24141124
77	cholesterol homeostasis (GO:0042632)	4.23795191
78	adhesion of symbiont to host cell (GO:0044650)	4.21917432
79	virion attachment to host cell (GO:0019062)	4.21917432
80	lysine catabolic process (GO:0006554)	4.19540602
81	lysine metabolic process (GO:0006553)	4.19540602
82	sterol homeostasis (GO:0055092)	4.17420555
83	lipoprotein metabolic process (GO:0042157)	4.16433118
84	tyrosine metabolic process (GO:0006570)	4.14793794
85	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.13012899
86	cellular ketone body metabolic process (GO:0046950)	4.11790866
87	plasma lipoprotein particle organization (GO:0071827)	4.07798186
88	alpha-amino acid catabolic process (GO:1901606)	4.04697377
89	vitamin transmembrane transport (GO:0035461)	4.04501507
90	peptide catabolic process (GO:0043171)	4.03063946
91	omega-hydroxylase P450 pathway (GO:0097267)	4.02847162
92	positive regulation of lipid catabolic process (GO:0050996)	4.01376210
93	regulation of complement activation (GO:0030449)	3.99005986
94	low-density lipoprotein particle remodeling (GO:0034374)	3.95516638
95	glutamate metabolic process (GO:0006536)	3.92773369
96	regulation of cholesterol homeostasis (GO:2000188)	3.91496027
97	regulation of cellular extravasation (GO:0002691)	3.89918677
98	arginine metabolic process (GO:0006525)	3.89910262
99	peptide hormone processing (GO:0016486)	3.89160713
100	protein-lipid complex subunit organization (GO:0071825)	3.87562043
101	phospholipid homeostasis (GO:0055091)	3.87234187
102	vitamin transport (GO:0051180)	3.79763692
103	glucuronate metabolic process (GO:0019585)	3.77629365
104	uronic acid metabolic process (GO:0006063)	3.77629365
105	drug metabolic process (GO:0017144)	3.75961737
106	cellular amino acid catabolic process (GO:0009063)	3.75812876
107	benzene-containing compound metabolic process (GO:0042537)	3.73073350
108	cellular modified amino acid catabolic process (GO:0042219)	3.72046596
109	indolalkylamine metabolic process (GO:0006586)	3.68660779
110	glycine metabolic process (GO:0006544)	3.68600443
111	midgut development (GO:0007494)	3.67803135
112	imidazole-containing compound metabolic process (GO:0052803)	3.66978075
113	serine family amino acid metabolic process (GO:0009069)	3.66632539
114	coenzyme catabolic process (GO:0009109)	3.65789237
115	negative regulation of lipase activity (GO:0060192)	3.65146727
116	adhesion of symbiont to host (GO:0044406)	3.64487272
117	regulation of cGMP metabolic process (GO:0030823)	3.63565369
118	serine family amino acid biosynthetic process (GO:0009070)	3.63237832
119	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.61448214
120	digestion (GO:0007586)	3.58946638
121	cellular biogenic amine catabolic process (GO:0042402)	3.58560755
122	amine catabolic process (GO:0009310)	3.58560755
123	exogenous drug catabolic process (GO:0042738)	3.57641401
124	ketone body metabolic process (GO:1902224)	3.55460529
125	sterol transport (GO:0015918)	3.54884146
126	cholesterol transport (GO:0030301)	3.54884146
127	regulation of macrophage chemotaxis (GO:0010758)	3.54151313
128	heme transport (GO:0015886)	3.53382559
129	antibacterial humoral response (GO:0019731)	3.53122838
130	positive regulation of triglyceride metabolic process (GO:0090208)	3.52491980
131	dicarboxylic acid biosynthetic process (GO:0043650)	3.51701820
132	ethanol oxidation (GO:0006069)	3.51574905
133	vitamin biosynthetic process (GO:0009110)	3.48724535
134	glutamine family amino acid biosynthetic process (GO:0009084)	3.48648149
135	fat-soluble vitamin metabolic process (GO:0006775)	3.48180850
136	drug transmembrane transport (GO:0006855)	3.47595152
137	response to nitrosative stress (GO:0051409)	3.46609787
138	maintenance of gastrointestinal epithelium (GO:0030277)	3.43912253
139	urate metabolic process (GO:0046415)	3.43741304
140	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.42626094
141	antimicrobial humoral response (GO:0019730)	3.42223086
142	vitamin A metabolic process (GO:0006776)	3.40574705
143	positive regulation of pseudopodium assembly (GO:0031274)	3.39552469
144	glycerol metabolic process (GO:0006071)	3.34735110
145	L-ascorbic acid metabolic process (GO:0019852)	3.29786056
146	drinking behavior (GO:0042756)	3.29413848
147	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.28504402
148	drug transport (GO:0015893)	3.21790941
149	cellular response to nitric oxide (GO:0071732)	3.18363632
150	ethanol metabolic process (GO:0006067)	3.18039192
151	glycolipid catabolic process (GO:0019377)	3.15380084
152	regulation of vitamin metabolic process (GO:0030656)	3.09477468
153	positive regulation of cGMP biosynthetic process (GO:0030828)	3.08906099
154	glycosphingolipid catabolic process (GO:0046479)	3.07940317
155	positive regulation of glycoprotein metabolic process (GO:1903020)	3.07581170
156	proline metabolic process (GO:0006560)	3.07074554
157	alditol metabolic process (GO:0019400)	3.06818930
158	phenylpropanoid metabolic process (GO:0009698)	3.06209275
159	regulation of pseudopodium assembly (GO:0031272)	3.01489001

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.85302578
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.87368529
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.33188684
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.20801620
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.72199921
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.71670612
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.66328795
8	* NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.78822594
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.46756804
10	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.49575396
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.28442784
12	* ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.0030269
13	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.90119161
14	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.70885504
15	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68606381
16	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.66143891
17	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.65875762
18	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.65846587
19	CLOCK_20551151_ChIP-Seq_293T_Human	1.60757885
20	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.54550386
21	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.53221346
22	GATA4_25053715_ChIP-Seq_YYC3_Human	1.44880381
23	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.39072981
24	HTT_18923047_ChIP-ChIP_STHdh_Human	1.37401772
25	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.37341280
26	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.36700530
27	GATA1_22025678_ChIP-Seq_K562_Human	1.30393772
28	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.26653034
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.25508867
30	SA1_27219007_Chip-Seq_Bcells_Human	1.21009816
31	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.20006132
32	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.17250155
33	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.13740280
34	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.11551758
35	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.07747028
36	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.03931332
37	BCL6_27268052_Chip-Seq_Bcells_Human	1.02336551
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01911241
39	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00101308
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98653006
41	GATA6_25053715_ChIP-Seq_YYC3_Human	0.98646842
42	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.98495500
43	MYC_19829295_ChIP-Seq_ESCs_Human	0.97554520
44	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.97470849
45	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97159654
46	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.95632950
47	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.95363044
48	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92591006
49	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.92481786
50	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.92006137
51	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.91520800
52	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.91340719
53	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.90471887
54	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.90459000
55	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.89990739
56	SOX2_20726797_ChIP-Seq_SW620_Human	0.89269069
57	STAT1_20625510_ChIP-Seq_HELA_Human	0.88164572
58	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.86720465
59	CDX2_22108803_ChIP-Seq_LS180_Human	0.85373733
60	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.85300664
61	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.83152472
62	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.82914723
63	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.82584065
64	SOX2_21211035_ChIP-Seq_LN229_Human	0.82377450
65	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.82131393
66	KLF5_25053715_ChIP-Seq_YYC3_Human	0.81572663
67	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.80891476
68	RXR_22108803_ChIP-Seq_LS180_Human	0.80801487
69	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.79930256
70	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.79441058
71	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.79409597
72	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.78275912
73	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.77585693
74	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.76714859
75	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.76606829
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.74895140
77	ZNF263_19887448_ChIP-Seq_K562_Human	0.74620489
78	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.74457213
79	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.74408620
80	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.74274096
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.74113294
82	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.73558865
83	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.73235390
84	* LXR_22292898_ChIP-Seq_THP-1_Human	0.72622669
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.72067307
86	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.71787596
87	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.71640955
88	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.71591051
89	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.70641651
90	* SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.70588584
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.70473168
92	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.70428732
93	GATA2_19941826_ChIP-Seq_K562_Human	0.70037211
94	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.69710271
95	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.69619774
96	EGR1_19032775_ChIP-ChIP_M12_Human	0.69374393
97	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.66722629
98	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.65419754
99	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.63319315
100	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.62673657
101	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.61887199
102	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.61017897
103	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.60669999
104	MYC_19915707_ChIP-ChIP_AK7_Human	0.60513886
105	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.60404756
106	GATA1_19941826_ChIP-Seq_K562_Human	0.60177739
107	CEBPB_22108803_ChIP-Seq_LS180_Human	0.59702517
108	STAT1_17558387_ChIP-Seq_HELA_Human	0.58851660
109	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.58196671
110	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.57907556
111	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.57549173
112	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.57497156
113	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.55952623
114	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.55946197
115	RACK7_27058665_Chip-Seq_MCF-7_Human	0.55330034
116	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.55309251
117	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.55309251
118	TAF2_19829295_ChIP-Seq_ESCs_Human	0.54044243
119	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.53913107
120	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.53825455
121	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.53730826
122	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.53723737
123	AR_20517297_ChIP-Seq_VCAP_Human	0.52717112
124	BCAT_22108803_ChIP-Seq_LS180_Human	0.52626016
125	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.51874108
126	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.50845346
127	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.50773892
128	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.50136449
129	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.49082243
130	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.49039228
131	P53_21459846_ChIP-Seq_SAOS-2_Human	0.48450969
132	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.48040373
133	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.48006223
134	CBP_21632823_ChIP-Seq_H3396_Human	0.47982371
135	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.47797362
136	BCOR_27268052_Chip-Seq_Bcells_Human	0.46938362
137	* CTCF_27219007_Chip-Seq_Bcells_Human	0.44543678
138	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.44497065
139	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.43820893

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	8.91260858
2	MP0002139_abnormal_hepatobiliary_system	7.81377212
3	MP0005085_abnormal_gallbladder_physiolo	5.97344975
4	MP0005365_abnormal_bile_salt	5.48596837
5	MP0008875_abnormal_xenobiotic_pharmacok	5.02725154
6	MP0009840_abnormal_foam_cell	3.98970951
7	MP0003252_abnormal_bile_duct	3.95059651
8	MP0009379_abnormal_foot_pigmentation	3.83318978
9	MP0003806_abnormal_nucleotide_metabolis	3.73603681
10	MP0001666_abnormal_nutrient_absorption	3.73586116
11	MP0010329_abnormal_lipoprotein_level	3.67489189
12	MP0005332_abnormal_amino_acid	2.63218944
13	MP0005083_abnormal_biliary_tract	2.44479418
14	MP0003191_abnormal_cellular_cholesterol	2.37701994
15	MP0004019_abnormal_vitamin_homeostasis	2.35443879
16	MP0003195_calcinosis	2.22813019
17	MP0000609_abnormal_liver_physiology	2.00673115
18	MP0002118_abnormal_lipid_homeostasis	2.00550436
19	MP0005409_darkened_coat_color	1.81863348
20	MP0009697_abnormal_copulation	1.69837468
21	MP0005319_abnormal_enzyme/_coenzyme	1.66027771
22	MP0003868_abnormal_feces_composition	1.64502891
23	MP0002138_abnormal_hepatobiliary_system	1.61761205
24	MP0001664_abnormal_digestion	1.53927488
25	MP0003879_abnormal_hair_cell	1.52814050
26	MP0001764_abnormal_homeostasis	1.51193648
27	MP0005451_abnormal_body_composition	1.49579912
28	MP0001188_hyperpigmentation	1.48264149
29	MP0005584_abnormal_enzyme/coenzyme_acti	1.43921107
30	MP0004858_abnormal_nervous_system	1.41909926
31	MP0010234_abnormal_vibrissa_follicle	1.37990379
32	MP0000566_synostosis	1.36199049
33	MP0000678_abnormal_parathyroid_gland	1.35594998
34	MP0009643_abnormal_urine_homeostasis	1.35371261
35	MP0003705_abnormal_hypodermis_morpholog	1.34824220
36	MP0000490_abnormal_crypts_of	1.26456234
37	MP0000604_amyloidosis	1.14516961
38	MP0002254_reproductive_system_inflammat	1.13996511
39	MP0005084_abnormal_gallbladder_morpholo	1.13506942
40	MP0003656_abnormal_erythrocyte_physiolo	1.11831779
41	MP0000537_abnormal_urethra_morphology	1.11615436
42	MP0004270_analgesia	1.09944282
43	MP0004264_abnormal_extraembryonic_tissu	1.07051875
44	MP0002098_abnormal_vibrissa_morphology	1.04858964
45	MP0000598_abnormal_liver_morphology	1.03510289
46	MP0002822_catalepsy	1.00948269
47	MP0003011_delayed_dark_adaptation	0.98016670
48	MP0001485_abnormal_pinna_reflex	0.97164307
49	MP0002876_abnormal_thyroid_physiology	0.95313144
50	MP0005636_abnormal_mineral_homeostasis	0.94253462
51	MP0009764_decreased_sensitivity_to	0.89879427
52	MP0003186_abnormal_redox_activity	0.87051057
53	MP0009642_abnormal_blood_homeostasis	0.86766088
54	MP0010352_gastrointestinal_tract_polyps	0.86462301
55	MP0005448_abnormal_energy_balance	0.84564039
56	MP0009763_increased_sensitivity_to	0.80578045
57	MP0008469_abnormal_protein_level	0.78168257
58	MP0005376_homeostasis/metabolism_phenot	0.77646663
59	MP0001501_abnormal_sleep_pattern	0.76330228
60	MP0004742_abnormal_vestibular_system	0.76221664
61	MP0009765_abnormal_xenobiotic_induced	0.74369734
62	MP0009053_abnormal_anal_canal	0.74132146
63	MP0002078_abnormal_glucose_homeostasis	0.72482822
64	MP0005266_abnormal_metabolism	0.70902472
65	MP0005408_hypopigmentation	0.70062955
66	MP0005647_abnormal_sex_gland	0.69820905
67	MP0003183_abnormal_peptide_metabolism	0.69652440
68	MP0002971_abnormal_brown_adipose	0.68454877
69	MP0000462_abnormal_digestive_system	0.65941153
70	MP0006036_abnormal_mitochondrial_physio	0.65100576
71	MP0004043_abnormal_pH_regulation	0.64578977
72	MP0010678_abnormal_skin_adnexa	0.63583565
73	MP0003718_maternal_effect	0.63553150
74	MP0005334_abnormal_fat_pad	0.62824749
75	MP0003329_amyloid_beta_deposits	0.62309639
76	MP0002249_abnormal_larynx_morphology	0.60594801
77	MP0001873_stomach_inflammation	0.58979759
78	MP0001756_abnormal_urination	0.57861591
79	MP0010368_abnormal_lymphatic_system	0.57678691
80	MP0000427_abnormal_hair_cycle	0.56931369
81	MP0008872_abnormal_physiological_respon	0.56768383
82	MP0002136_abnormal_kidney_physiology	0.56199476
83	MP0000383_abnormal_hair_follicle	0.55976573
84	MP0002796_impaired_skin_barrier	0.55697077
85	MP0004147_increased_porphyrin_level	0.55062728
86	MP0006138_congestive_heart_failure	0.52220521
87	MP0005535_abnormal_body_temperature	0.51983590
88	MP0000538_abnormal_urinary_bladder	0.51388644
89	MP0003638_abnormal_response/metabolism_	0.50716192
90	MP0005464_abnormal_platelet_physiology	0.50345850
91	MP0002896_abnormal_bone_mineralization	0.49845108
92	MP0005220_abnormal_exocrine_pancreas	0.47682107
93	MP0000516_abnormal_urinary_system	0.47461214
94	MP0005367_renal/urinary_system_phenotyp	0.47461214
95	MP0003690_abnormal_glial_cell	0.47446345
96	MP0001663_abnormal_digestive_system	0.46540307
97	MP0008873_increased_physiological_sensi	0.46143430
98	MP0001727_abnormal_embryo_implantation	0.46041447
99	MP0005501_abnormal_skin_physiology	0.45986824
100	MP0000639_abnormal_adrenal_gland	0.45760907
101	MP0005166_decreased_susceptibility_to	0.45750409
102	MP0003300_gastrointestinal_ulcer	0.44391391
103	MP0003878_abnormal_ear_physiology	0.44362129
104	MP0005377_hearing/vestibular/ear_phenot	0.44362129
105	MP0005395_other_phenotype	0.44237168
106	MP0005670_abnormal_white_adipose	0.44230480
107	MP0005381_digestive/alimentary_phenotyp	0.43796318
108	MP0009785_altered_susceptibility_to	0.43031349
109	MP0005167_abnormal_blood-brain_barrier	0.42888947
110	MP0003315_abnormal_perineum_morphology	0.42568990
111	MP0003953_abnormal_hormone_level	0.41999093
112	MP0010155_abnormal_intestine_physiology	0.41330307
113	MP0006035_abnormal_mitochondrial_morpho	0.38706118
114	MP0009115_abnormal_fat_cell	0.37624354
115	MP0000230_abnormal_systemic_arterial	0.36800075
116	MP0003075_altered_response_to	0.36379444
117	MP0000249_abnormal_blood_vessel	0.35783569
118	MP0000477_abnormal_intestine_morphology	0.35686441
119	MP0005248_abnormal_Harderian_gland	0.35660517
120	MP0001661_extended_life_span	0.35208762
121	MP0008874_decreased_physiological_sensi	0.34953068
122	MP0004782_abnormal_surfactant_physiolog	0.32783148
123	MP0003866_abnormal_defecation	0.32670925
124	MP0003436_decreased_susceptibility_to	0.32588126
125	MP0005666_abnormal_adipose_tissue	0.32017420
126	MP0004130_abnormal_muscle_cell	0.31982222
127	MP0003453_abnormal_keratinocyte_physiol	0.31263285
128	MP0001765_abnormal_ion_homeostasis	0.30730389
129	MP0001881_abnormal_mammary_gland	0.30632615
130	MP0001845_abnormal_inflammatory_respons	0.29872800
131	MP0009384_cardiac_valve_regurgitation	0.29826699

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	7.25189274
2	Intrahepatic cholestasis (HP:0001406)	6.71465323
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.60813608
4	Deep venous thrombosis (HP:0002625)	6.53166611
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.45629909
6	Xanthomatosis (HP:0000991)	6.13607939
7	Prolonged partial thromboplastin time (HP:0003645)	5.71369646
8	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.43969751
9	Hypolipoproteinemia (HP:0010981)	5.18007881
10	Hyperlipoproteinemia (HP:0010980)	4.97622882
11	Abnormality of the vitamin B12 metabolism (HP:0004341)	4.64676029
12	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.59791006
13	Hyperammonemia (HP:0001987)	4.47884526
14	Widely patent fontanelles and sutures (HP:0004492)	4.44824726
15	Fat malabsorption (HP:0002630)	4.39817138
16	Chronic diarrhea (HP:0002028)	4.34430604
17	Abnormality of vitamin B metabolism (HP:0004340)	4.32771036
18	Hyperglycinuria (HP:0003108)	4.31293025
19	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.30913447
20	Conjugated hyperbilirubinemia (HP:0002908)	4.28643819
21	Epidermoid cyst (HP:0200040)	4.27832100
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.27197356
23	Complement deficiency (HP:0004431)	4.11333972
24	Joint hemorrhage (HP:0005261)	4.07522397
25	Hypoalphalipoproteinemia (HP:0003233)	4.05431191
26	Abnormality of the common coagulation pathway (HP:0010990)	4.01876575
27	Abnormality of serine family amino acid metabolism (HP:0010894)	3.99596950
28	Abnormality of glycine metabolism (HP:0010895)	3.99596950
29	Ketosis (HP:0001946)	3.91047503
30	Hyperglycinemia (HP:0002154)	3.82475783
31	Hypercholesterolemia (HP:0003124)	3.79871128
32	Acanthocytosis (HP:0001927)	3.74388217
33	Hypoglycemic coma (HP:0001325)	3.70795391
34	Abnormality of methionine metabolism (HP:0010901)	3.66292631
35	Abnormality of pyrimidine metabolism (HP:0004353)	3.55413272
36	Potter facies (HP:0002009)	3.47205262
37	Facial shape deformation (HP:0011334)	3.47205262
38	Hyperphosphaturia (HP:0003109)	3.38043483
39	Hyperbilirubinemia (HP:0002904)	3.35762626
40	Malnutrition (HP:0004395)	3.34629829
41	Abnormality of the intrinsic pathway (HP:0010989)	3.33114982
42	Wide cranial sutures (HP:0010537)	3.30187131
43	Increased purine levels (HP:0004368)	3.28591058
44	Hyperuricemia (HP:0002149)	3.28591058
45	Abnormal urine phosphate concentration (HP:0012599)	3.28318707
46	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.22988084
47	Thin bony cortex (HP:0002753)	3.21649158
48	Abnormality of fatty-acid metabolism (HP:0004359)	3.18767464
49	Abnormality of nucleobase metabolism (HP:0010932)	3.17827180
50	Hyperparathyroidism (HP:0000843)	3.16102754
51	Ketoacidosis (HP:0001993)	3.00816528
52	Abnormality of purine metabolism (HP:0004352)	2.99034135
53	Abnormality of complement system (HP:0005339)	2.98218281
54	Hydroxyprolinuria (HP:0003080)	2.98188685
55	Abnormality of proline metabolism (HP:0010907)	2.98188685
56	Metabolic acidosis (HP:0001942)	2.97655348
57	Congenital sensorineural hearing impairment (HP:0008527)	2.96104093
58	Ileus (HP:0002595)	2.87944654
59	Megaloblastic anemia (HP:0001889)	2.86727840
60	Spontaneous abortion (HP:0005268)	2.82902098
61	Hypophosphatemia (HP:0002148)	2.80838229
62	Steatorrhea (HP:0002570)	2.78538316
63	Delayed CNS myelination (HP:0002188)	2.74194010
64	Abdominal distention (HP:0003270)	2.71976826
65	Hepatocellular carcinoma (HP:0001402)	2.68881936
66	Poikilocytosis (HP:0004447)	2.68064085
67	Skin nodule (HP:0200036)	2.64004236
68	Decreased circulating renin level (HP:0003351)	2.61011934
69	Abnormal gallbladder physiology (HP:0012438)	2.60604645
70	Cholecystitis (HP:0001082)	2.60604645
71	Vascular calcification (HP:0004934)	2.58093227
72	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.57139723
73	Osteolytic defects of the hand bones (HP:0009699)	2.57139723
74	Abnormality of serum amino acid levels (HP:0003112)	2.55251365
75	Myocardial infarction (HP:0001658)	2.51437412
76	Lethargy (HP:0001254)	2.49545005
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.48696279
78	Dicarboxylic aciduria (HP:0003215)	2.48696279
79	Nephritis (HP:0000123)	2.45239217
80	Amyloidosis (HP:0011034)	2.44201103
81	Abnormal gallbladder morphology (HP:0012437)	2.43648506
82	Cholelithiasis (HP:0001081)	2.39672779
83	Hypochromic microcytic anemia (HP:0004840)	2.37700975
84	Hypoglycemic seizures (HP:0002173)	2.36367452
85	Cerebral palsy (HP:0100021)	2.35188712
86	Systemic lupus erythematosus (HP:0002725)	2.34237157
87	Gout (HP:0001997)	2.34091045
88	Late onset (HP:0003584)	2.32465163
89	Irritability (HP:0000737)	2.30978903
90	Glycosuria (HP:0003076)	2.29743019
91	Abnormality of urine glucose concentration (HP:0011016)	2.29743019
92	Metabolic alkalosis (HP:0200114)	2.28752498
93	Focal segmental glomerulosclerosis (HP:0000097)	2.28734546
94	Esophageal varix (HP:0002040)	2.28238140
95	Cardiovascular calcification (HP:0011915)	2.27402319
96	Delayed epiphyseal ossification (HP:0002663)	2.25196688
97	Pancreatitis (HP:0001733)	2.23749035
98	Renal tubular dysfunction (HP:0000124)	2.22803626
99	Glomerulonephritis (HP:0000099)	2.21326061
100	Protuberant abdomen (HP:0001538)	2.19230219
101	Spastic diplegia (HP:0001264)	2.19224515
102	Posterior subcapsular cataract (HP:0007787)	2.14797818
103	Sensorimotor neuropathy (HP:0007141)	2.13508341
104	Cerebral edema (HP:0002181)	2.12055911
105	Reticulocytosis (HP:0001923)	2.10973834
106	Vomiting (HP:0002013)	2.08911030
107	Generalized aminoaciduria (HP:0002909)	2.06310693
108	Hypotension (HP:0002615)	2.06009988
109	Abnormal glucose tolerance (HP:0001952)	2.05232141
110	Abnormality of vitamin metabolism (HP:0100508)	2.04910501
111	Amblyopia (HP:0000646)	2.04353503
112	Renal tubular acidosis (HP:0001947)	2.03608971
113	Pigmentary retinal degeneration (HP:0001146)	2.03080198
114	Proximal tubulopathy (HP:0000114)	1.98913286
115	Abnormality of alkaline phosphatase activity (HP:0004379)	1.98433308
116	Abnormal enzyme/coenzyme activity (HP:0012379)	1.98015147
117	Abnormality of the gallbladder (HP:0005264)	1.97865056
118	Enlarged epiphyses (HP:0010580)	1.97794768
119	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96750599
120	Mitral stenosis (HP:0001718)	1.95419585
121	Menorrhagia (HP:0000132)	1.95102787
122	Nephrolithiasis (HP:0000787)	1.93687633
123	Neonatal onset (HP:0003623)	1.93246903
124	Gingival bleeding (HP:0000225)	1.93077506
125	Abnormality of transition element cation homeostasis (HP:0011030)	1.92238670
126	Rickets (HP:0002748)	1.91925979
127	Increased mean platelet volume (HP:0011877)	1.91525169
128	Brushfield spots (HP:0001088)	1.89685158
129	Abnormality of renin-angiotensin system (HP:0000847)	1.88514776
130	Confusion (HP:0001289)	1.88257890
131	Enlarged kidneys (HP:0000105)	1.88215087
132	Abnormal cartilage morphology (HP:0002763)	1.86355794
133	Nausea (HP:0002018)	1.85739575
134	Hyperactive renin-angiotensin system (HP:0000841)	1.85530140
135	Hemorrhage of the eye (HP:0011885)	1.85018765
136	Alkalosis (HP:0001948)	1.84144154
137	Abnormality of the costochondral junction (HP:0000919)	1.82760373
138	Autoimmune thrombocytopenia (HP:0001973)	1.81772933
139	Elevated alkaline phosphatase (HP:0003155)	1.74502561
140	Villous atrophy (HP:0011473)	1.71796292
141	Abnormality of small intestinal villus morphology (HP:0011472)	1.71796292
142	Glomerulosclerosis (HP:0000096)	1.71364237
143	Hyperphosphatemia (HP:0002905)	1.70942096
144	Growth hormone excess (HP:0000845)	1.70613653

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BRSK2	6.76839581
2	ACVR1B	6.29736928
3	BCKDK	5.52955243
4	ERN1	4.35512365
5	FRK	4.26186489
6	WEE1	3.91106431
7	FGFR4	3.59090212
8	SIK1	3.56427157
9	MST1R	3.54665730
10	BRSK1	2.88750205
11	GRK6	2.57147912
12	TAOK3	2.56441197
13	INSRR	2.30944100
14	SMG1	2.20819593
15	RIPK1	2.18923187
16	PTK6	2.11296841
17	ERBB4	2.01351306
18	PKN2	1.87772674
19	CASK	1.81990370
20	MAP2K4	1.75459768
21	AKT3	1.61680561
22	MAP3K10	1.60771117
23	MAPK11	1.60019009
24	MAP2K2	1.59046702
25	LMTK2	1.54155005
26	TYK2	1.47889164
27	TNIK	1.46591294
28	LATS1	1.45426382
29	PRKG2	1.42881983
30	PDK2	1.36874241
31	MET	1.34719419
32	FLT3	1.34425919
33	MAP3K11	1.34268056
34	TRIB3	1.33478866
35	MAP3K7	1.33113196
36	DDR2	1.29776097
37	MAP3K12	1.28443047
38	PRKAA2	1.25223100
39	MAP3K3	1.24534788
40	DAPK2	1.22900087
41	PIK3CG	1.21008520
42	KDR	1.13121729
43	PTK2	1.08107626
44	MAP3K2	1.06095562
45	MAP2K6	1.04226748
46	ERBB2	1.01545413
47	TBK1	1.01212375
48	EPHB1	0.98534342
49	ABL2	0.97419694
50	STK39	0.97144828
51	PIK3CA	0.95413915
52	PBK	0.94993815
53	MST4	0.92023342
54	EPHA2	0.91879572
55	TAF1	0.91062772
56	JAK2	0.88014188
57	NME1	0.87631972
58	OXSR1	0.87285152
59	NUAK1	0.85834190
60	MATK	0.84300403
61	TESK1	0.84287184
62	MAP2K3	0.83206558
63	VRK2	0.81959464
64	PRKCZ	0.80922556
65	MAPK4	0.78686080
66	IRAK3	0.78651343
67	EPHB2	0.78553790
68	MAP3K14	0.76163371
69	MAP2K1	0.74607438
70	PRKACG	0.73130710
71	CSK	0.72360538
72	BMPR1B	0.71543916
73	PRKAA1	0.69427161
74	NEK9	0.68063548
75	TAOK1	0.67165248
76	CAMK2G	0.67135909
77	DYRK1B	0.66456760
78	JAK1	0.64010245
79	FGFR3	0.63890640
80	ICK	0.61832017
81	GSK3A	0.61631890
82	BLK	0.61433233
83	CDK6	0.61046953
84	PDPK1	0.60945910
85	FGFR2	0.60611482
86	TAOK2	0.60326729
87	MAP3K1	0.56426084
88	CDC42BPA	0.54700227
89	SGK3	0.54056072
90	BMX	0.53858360
91	KSR2	0.52518335
92	PRKCQ	0.50421952
93	STK38L	0.49568842
94	GRK1	0.49557423
95	MAPK15	0.47750416
96	PDGFRA	0.46326590
97	MELK	0.44864198
98	GRK5	0.44843901
99	STK24	0.44688464
100	MYLK	0.43388053
101	EPHA4	0.42809583
102	MAPK12	0.42697726
103	FER	0.41245787
104	TIE1	0.39274218
105	PAK4	0.38300462
106	IKBKE	0.37538763
107	PRKCA	0.37513355
108	CAMK2D	0.37060399
109	EPHA3	0.36874499
110	PRPF4B	0.36226571
111	MAP3K5	0.36073880
112	PINK1	0.35053494
113	MAP3K8	0.34934261
114	MAP3K6	0.34767524
115	PDK1	0.34140752
116	CAMK2B	0.34104402
117	TYRO3	0.33087846
118	TESK2	0.32090283
119	SRC	0.31893544
120	PAK3	0.31520051
121	HIPK2	0.29856826
122	MAP4K1	0.29284661
123	TGFBR2	0.29254933
124	CAMK1D	0.28851191
125	IGF1R	0.27289520
126	WNK4	0.26547802
127	PRKG1	0.26512732
128	NLK	0.25945986
129	UHMK1	0.25658504
130	STK10	0.25134976
131	MAPK7	0.24606424
132	CDK4	0.23628154
133	RET	0.23348646
134	PIM1	0.22326803
135	FYN	0.20572126
136	WNK3	0.19391820
137	PRKCD	0.19245889
138	CDK9	0.18359199
139	DAPK3	0.18176915
140	STK11	0.18090032
141	MAP3K13	0.16781380
142	YES1	0.16272434
143	PRKACA	0.14571672
144	FGR	0.11473240
145	CSF1R	0.10704379

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.78148609
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.44659915
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.36390843
4	Arginine biosynthesis_Homo sapiens_hsa00220	3.02357186
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.89877715
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.59213995
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.45752185
8	Fat digestion and absorption_Homo sapiens_hsa04975	2.45361657
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.42718149
10	Fatty acid degradation_Homo sapiens_hsa00071	2.38435297
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.28554726
12	Complement and coagulation cascades_Homo sapiens_hsa04610	2.25460587
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.21296137
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.16914586
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.14660418
16	Histidine metabolism_Homo sapiens_hsa00340	2.07585612
17	Caffeine metabolism_Homo sapiens_hsa00232	2.01814885
18	Butanoate metabolism_Homo sapiens_hsa00650	1.95156513
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.94379788
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.89830707
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.88885634
22	Peroxisome_Homo sapiens_hsa04146	1.86494749
23	Bile secretion_Homo sapiens_hsa04976	1.86355997
24	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.81046502
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.76909009
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.72471679
27	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.70842239
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.70639245
29	Sulfur metabolism_Homo sapiens_hsa00920	1.69665251
30	Fatty acid metabolism_Homo sapiens_hsa01212	1.67598435
31	Propanoate metabolism_Homo sapiens_hsa00640	1.67440633
32	Retinol metabolism_Homo sapiens_hsa00830	1.60930813
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.60118861
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.59298237
35	Folate biosynthesis_Homo sapiens_hsa00790	1.57460581
36	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.51451620
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48983187
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.44278300
39	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.41272813
40	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.40692710
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.40482811
42	Phenylalanine metabolism_Homo sapiens_hsa00360	1.37312413
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.34393585
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.25800797
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.23174915
46	ABC transporters_Homo sapiens_hsa02010	1.21240926
47	Tyrosine metabolism_Homo sapiens_hsa00350	1.19835586
48	Fatty acid elongation_Homo sapiens_hsa00062	1.19578748
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18740494
50	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.16374752
51	Steroid biosynthesis_Homo sapiens_hsa00100	1.16109389
52	Carbon metabolism_Homo sapiens_hsa01200	1.15692875
53	Arginine and proline metabolism_Homo sapiens_hsa00330	1.11139828
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.10586234
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98611779
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96489895
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.92591555
58	Glutathione metabolism_Homo sapiens_hsa00480	0.90564259
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90079885
60	Renin-angiotensin system_Homo sapiens_hsa04614	0.87152822
61	Galactose metabolism_Homo sapiens_hsa00052	0.86414202
62	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85254217
63	Lysine degradation_Homo sapiens_hsa00310	0.73030736
64	Sulfur relay system_Homo sapiens_hsa04122	0.72694357
65	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.68878217
66	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.68812968
67	Asthma_Homo sapiens_hsa05310	0.68763254
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.68208218
69	Mineral absorption_Homo sapiens_hsa04978	0.65517343
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53083784
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49147719
72	Pancreatic secretion_Homo sapiens_hsa04972	0.47574661
73	Metabolic pathways_Homo sapiens_hsa01100	0.47296397
74	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45889269
75	One carbon pool by folate_Homo sapiens_hsa00670	0.45252110
76	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.41773319
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41605729
78	Allograft rejection_Homo sapiens_hsa05330	0.34705945
79	Linoleic acid metabolism_Homo sapiens_hsa00591	0.33942967
80	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.32095219
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30780689
82	Graft-versus-host disease_Homo sapiens_hsa05332	0.27500561
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.26231316
84	Cocaine addiction_Homo sapiens_hsa05030	0.23243571
85	Other glycan degradation_Homo sapiens_hsa00511	0.22686253
86	Renin secretion_Homo sapiens_hsa04924	0.20736339
87	Insulin resistance_Homo sapiens_hsa04931	0.19338004
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.18267698
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.17731058
90	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.15455528
91	Pertussis_Homo sapiens_hsa05133	0.15403217
92	Type I diabetes mellitus_Homo sapiens_hsa04940	0.14782999
93	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.14266016
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.10892209
95	Regulation of autophagy_Homo sapiens_hsa04140	0.10055668
96	Antigen processing and presentation_Homo sapiens_hsa04612	0.07274085
97	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.06333756
98	Serotonergic synapse_Homo sapiens_hsa04726	0.05480302
99	Insulin secretion_Homo sapiens_hsa04911	0.05417977
100	Prion diseases_Homo sapiens_hsa05020	0.03886866
101	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.00844006
102	Glucagon signaling pathway_Homo sapiens_hsa04922	0.00557991
103	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.2253241
104	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	-0.2154480
105	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.2038124
106	Bladder cancer_Homo sapiens_hsa05219	-0.2003820
107	Ether lipid metabolism_Homo sapiens_hsa00565	-0.1466247
108	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.1432505
109	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1400942
110	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1380157
111	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1376514
112	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	-0.1206910
113	Hepatitis C_Homo sapiens_hsa05160	-0.1039755
114	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0950709
115	African trypanosomiasis_Homo sapiens_hsa05143	-0.0614861
116	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0302278
117	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0247820
118	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.0173117
119	Amphetamine addiction_Homo sapiens_hsa05031	-0.0135871
120	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	-0.0077609

TM6SF2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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