ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.58315660
2	L-phenylalanine catabolic process (GO:0006559)	7.58315660
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.26454667
4	L-phenylalanine metabolic process (GO:0006558)	7.26454667
5	aromatic amino acid family catabolic process (GO:0009074)	6.71927985
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.23581369
7	indole-containing compound catabolic process (GO:0042436)	5.96691858
8	indolalkylamine catabolic process (GO:0046218)	5.96691858
9	tryptophan catabolic process (GO:0006569)	5.96691858
10	bile acid biosynthetic process (GO:0006699)	5.90006070
11	kynurenine metabolic process (GO:0070189)	5.71774621
12	biotin metabolic process (GO:0006768)	5.66556612
13	glyoxylate metabolic process (GO:0046487)	5.65886730
14	tryptophan metabolic process (GO:0006568)	5.60621883
15	high-density lipoprotein particle remodeling (GO:0034375)	5.57279740
16	glucocorticoid biosynthetic process (GO:0006704)	5.53108561
17	alpha-linolenic acid metabolic process (GO:0036109)	5.50707649
18	urea cycle (GO:0000050)	5.34382569
19	urea metabolic process (GO:0019627)	5.34382569
20	negative regulation of fibrinolysis (GO:0051918)	5.33538289
21	regulation of fibrinolysis (GO:0051917)	5.22746311
22	sulfur amino acid catabolic process (GO:0000098)	5.20300485
23	peptidyl-glutamic acid carboxylation (GO:0017187)	5.11334478
24	protein carboxylation (GO:0018214)	5.11334478
25	regulation of cholesterol esterification (GO:0010872)	5.07890844
26	cysteine metabolic process (GO:0006534)	5.03215770
27	bile acid metabolic process (GO:0008206)	5.02208447
28	complement activation, alternative pathway (GO:0006957)	4.96506414
29	nitrogen cycle metabolic process (GO:0071941)	4.95908238
30	regulation of protein activation cascade (GO:2000257)	4.95347317
31	aromatic amino acid family metabolic process (GO:0009072)	4.89183042
32	reverse cholesterol transport (GO:0043691)	4.87614297
33	serine family amino acid catabolic process (GO:0009071)	4.84487619
34	plasma lipoprotein particle remodeling (GO:0034369)	4.78858855
35	protein-lipid complex remodeling (GO:0034368)	4.78858855
36	macromolecular complex remodeling (GO:0034367)	4.78858855
37	tyrosine metabolic process (GO:0006570)	4.74134018
38	coenzyme catabolic process (GO:0009109)	4.68710939
39	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.64879260
40	regulation of complement activation (GO:0030449)	4.59597111
41	regulation of triglyceride catabolic process (GO:0010896)	4.56737131
42	alpha-amino acid catabolic process (GO:1901606)	4.51751847
43	homocysteine metabolic process (GO:0050667)	4.51543135
44	cellular ketone body metabolic process (GO:0046950)	4.51427995
45	phospholipid efflux (GO:0033700)	4.48790345
46	negative regulation of cholesterol transport (GO:0032375)	4.44924857
47	negative regulation of sterol transport (GO:0032372)	4.44924857
48	triglyceride homeostasis (GO:0070328)	4.40864974
49	acylglycerol homeostasis (GO:0055090)	4.40864974
50	plasma lipoprotein particle clearance (GO:0034381)	4.36051410
51	cellular biogenic amine catabolic process (GO:0042402)	4.32698793
52	amine catabolic process (GO:0009310)	4.32698793
53	indolalkylamine metabolic process (GO:0006586)	4.27902515
54	low-density lipoprotein particle remodeling (GO:0034374)	4.26534453
55	regulation of cholesterol biosynthetic process (GO:0045540)	4.26364188
56	cholesterol efflux (GO:0033344)	4.24838313
57	bile acid and bile salt transport (GO:0015721)	4.22568277
58	imidazole-containing compound metabolic process (GO:0052803)	4.20704385
59	amino-acid betaine metabolic process (GO:0006577)	4.20037638
60	glutamate metabolic process (GO:0006536)	4.17551397
61	cellular amino acid catabolic process (GO:0009063)	4.16794323
62	cellular glucuronidation (GO:0052695)	4.15758304
63	glycine metabolic process (GO:0006544)	4.14560097
64	aldehyde catabolic process (GO:0046185)	4.13776005
65	ethanol oxidation (GO:0006069)	4.10184358
66	arginine metabolic process (GO:0006525)	4.08714879
67	cellular modified amino acid catabolic process (GO:0042219)	4.02104661
68	cofactor catabolic process (GO:0051187)	4.00882567
69	serine family amino acid metabolic process (GO:0009069)	3.98147816
70	lysine metabolic process (GO:0006553)	3.97307302
71	lysine catabolic process (GO:0006554)	3.97307302
72	plasma lipoprotein particle assembly (GO:0034377)	3.95971624
73	benzene-containing compound metabolic process (GO:0042537)	3.95932096
74	ketone body metabolic process (GO:1902224)	3.94026789
75	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.91757905
76	acetyl-CoA metabolic process (GO:0006084)	3.90037898
77	serine family amino acid biosynthetic process (GO:0009070)	3.89005105
78	drug catabolic process (GO:0042737)	3.88409330
79	fibrinolysis (GO:0042730)	3.83878982
80	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	3.82396081
81	very-low-density lipoprotein particle assembly (GO:0034379)	3.80635875
82	uronic acid metabolic process (GO:0006063)	3.78295464
83	glucuronate metabolic process (GO:0019585)	3.78295464
84	dicarboxylic acid biosynthetic process (GO:0043650)	3.78121211
85	blood coagulation, intrinsic pathway (GO:0007597)	3.76039733
86	positive regulation of triglyceride lipase activity (GO:0061365)	3.72477333
87	positive regulation of lipoprotein lipase activity (GO:0051006)	3.72477333
88	acyl-CoA biosynthetic process (GO:0071616)	3.72268545
89	thioester biosynthetic process (GO:0035384)	3.72268545
90	short-chain fatty acid metabolic process (GO:0046459)	3.72187340
91	negative regulation of lipase activity (GO:0060192)	3.71991733
92	low-density lipoprotein particle clearance (GO:0034383)	3.70164296
93	glucocorticoid metabolic process (GO:0008211)	3.68083489
94	carboxylic acid catabolic process (GO:0046395)	3.64166803
95	organic acid catabolic process (GO:0016054)	3.64166803
96	plasma lipoprotein particle organization (GO:0071827)	3.63417964
97	cholesterol homeostasis (GO:0042632)	3.61959924
98	very long-chain fatty acid metabolic process (GO:0000038)	3.61517980
99	NAD biosynthetic process (GO:0009435)	3.57123119
100	heme transport (GO:0015886)	3.56795474
101	regulation of bile acid biosynthetic process (GO:0070857)	3.56229272
102	opsonization (GO:0008228)	3.55700883
103	protein activation cascade (GO:0072376)	3.55051767
104	sterol homeostasis (GO:0055092)	3.55033031
105	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.54230688
106	complement activation, classical pathway (GO:0006958)	3.53963865
107	protein-lipid complex assembly (GO:0065005)	3.52271901
108	complement activation (GO:0006956)	3.51560182
109	phospholipid homeostasis (GO:0055091)	3.48826865
110	nicotinamide nucleotide biosynthetic process (GO:0019359)	3.47970404
111	* cholesterol biosynthetic process (GO:0006695)	3.44290834
112	androgen biosynthetic process (GO:0006702)	3.41544923
113	regulation of cholesterol metabolic process (GO:0090181)	3.41370752
114	estrogen biosynthetic process (GO:0006703)	3.39518930
115	coenzyme A biosynthetic process (GO:0015937)	3.32101987
116	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	3.28714056
117	fatty-acyl-CoA metabolic process (GO:0035337)	3.25900676
118	pyrimidine nucleobase catabolic process (GO:0006208)	3.22920627
119	coenzyme A metabolic process (GO:0015936)	3.14050599
120	* sterol biosynthetic process (GO:0016126)	3.08413229
121	L-serine metabolic process (GO:0006563)	3.07563051
122	triglyceride biosynthetic process (GO:0019432)	3.00099674
123	acylglycerol biosynthetic process (GO:0046463)	2.96176661
124	neutral lipid biosynthetic process (GO:0046460)	2.96176661
125	C21-steroid hormone biosynthetic process (GO:0006700)	2.91821314
126	neurotransmitter catabolic process (GO:0042135)	2.87635543
127	acyl-CoA metabolic process (GO:0006637)	2.86931463
128	thioester metabolic process (GO:0035383)	2.86931463
129	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.85865307
130	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.85865307
131	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.85865307
132	carnitine shuttle (GO:0006853)	2.80995410
133	sex differentiation (GO:0007548)	2.80961653
134	fatty acid elongation (GO:0030497)	2.76919198
135	fatty acid transmembrane transport (GO:1902001)	2.76777920
136	response to follicle-stimulating hormone (GO:0032354)	2.70676026
137	diacylglycerol metabolic process (GO:0046339)	2.69515181
138	linoleic acid metabolic process (GO:0043651)	2.66689771
139	response to phenylpropanoid (GO:0080184)	2.59688782
140	regulation of glycogen (starch) synthase activity (GO:2000465)	2.56858642
141	ethanol metabolic process (GO:0006067)	2.51106052
142	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.50085616
143	regulation of cholesterol storage (GO:0010885)	2.50065929
144	fatty acid homeostasis (GO:0055089)	2.48199445
145	epithelial cell maturation (GO:0002070)	2.44337225
146	acylglycerol catabolic process (GO:0046464)	2.41970071
147	neutral lipid catabolic process (GO:0046461)	2.41970071
148	nucleobase catabolic process (GO:0046113)	2.41588130
149	triglyceride catabolic process (GO:0019433)	2.41337657
150	branched-chain amino acid catabolic process (GO:0009083)	2.41314379
151	fatty acid beta-oxidation (GO:0006635)	2.39679698
152	regulation of sequestering of triglyceride (GO:0010889)	2.38821933
153	positive regulation of hormone metabolic process (GO:0032352)	2.35837031
154	fatty acid catabolic process (GO:0009062)	2.35764127
155	monocarboxylic acid catabolic process (GO:0072329)	2.34658679
156	proline metabolic process (GO:0006560)	2.33434261
157	* steroid biosynthetic process (GO:0006694)	2.33289720
158	hormone biosynthetic process (GO:0042446)	2.32513868
159	toxin metabolic process (GO:0009404)	2.31708972
160	ketone biosynthetic process (GO:0042181)	2.30899249
161	carnitine metabolic process (GO:0009437)	2.30404881
162	axonal fasciculation (GO:0007413)	2.29758040
163	cellular response to gonadotropin stimulus (GO:0071371)	2.29606858
164	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.29452141
165	regulation of cholesterol homeostasis (GO:2000188)	2.29245581
166	* sterol metabolic process (GO:0016125)	2.28487171
167	epoxygenase P450 pathway (GO:0019373)	2.27532941
168	regulation of plasminogen activation (GO:0010755)	2.26278098

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.89601771
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.70068767
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.61217906
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.09303398
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.20579845
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.89523721
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.80047352
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.40217997
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.79907005
10	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.75639703
11	EZH2_22144423_ChIP-Seq_EOC_Human	3.34994504
12	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.16897649
13	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.15863688
14	LXR_22292898_ChIP-Seq_THP-1_Human	2.01626011
15	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.3067955
16	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.90126936
17	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.86596220
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.79821655
19	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.73338821
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.72388410
21	* HTT_18923047_ChIP-ChIP_STHdh_Human	1.70330307
22	* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.69857375
23	P68_20966046_ChIP-Seq_HELA_Human	1.67254001
24	* RACK7_27058665_Chip-Seq_MCF-7_Human	1.63785723
25	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.59700596
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.57389980
27	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53136758
28	* SMC4_20622854_ChIP-Seq_HELA_Human	1.49734478
29	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.49662807
30	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.47249393
31	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.46944126
32	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.44481218
33	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.42668892
34	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.40977570
35	CREB1_26743006_Chip-Seq_LNCaP_Human	1.37758783
36	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.37244432
37	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.36632584
38	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.36587663
39	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.36029366
40	* XRN2_22483619_ChIP-Seq_HELA_Human	1.35758055
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32361936
42	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.32223692
43	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.30969193
44	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.30540839
45	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.28653771
46	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.27828027
47	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.27828027
48	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.27638692
49	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.26320129
50	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22829650
51	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20920210
52	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20280543
53	KDM2B_26808549_Chip-Seq_K562_Human	1.20260286
54	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.18880796
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17790848
56	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.17522053
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13925644
58	* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.13163514
59	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.12983272
60	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.12200064
61	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.12058910
62	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.11605669
63	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.10165458
64	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.09933235
65	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.06942181
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05690288
67	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.05537310
68	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.05470314
69	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.04904889
70	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.04899687
71	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.04725836
72	TAF15_26573619_Chip-Seq_HEK293_Human	1.04455231
73	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.04406617
74	CLOCK_20551151_ChIP-Seq_293T_Human	1.02737081
75	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.02060115
76	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.01478074
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.01148972
78	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.99088892
79	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.98046880
80	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.96861658
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95840694
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95697679
83	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.95264034
84	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.94800364
85	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.94079915
86	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93088055
87	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.92736366
88	E2F1_20622854_ChIP-Seq_HELA_Human	0.91688411
89	PHF8_20622854_ChIP-Seq_HELA_Human	0.90840465
90	* BCL6_27268052_Chip-Seq_Bcells_Human	0.90804250
91	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.90795278
92	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.90780673
93	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.89876845
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.89569970
95	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.89162708
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.83501003
97	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.83321231
98	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.82366478
99	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.79141441
100	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.79141441
101	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.76251920
102	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.75258849
103	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.74665754
104	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.74615533
105	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.72928109
106	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.71501492
107	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.70355634
108	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.67326142
109	GATA4_25053715_ChIP-Seq_YYC3_Human	0.66311772
110	GBX2_23144817_ChIP-Seq_PC3_Human	0.66236488
111	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.65025540
112	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.62991523
113	MYC_19915707_ChIP-ChIP_AK7_Human	0.60108913
114	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.59246387
115	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.59152112
116	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.58710570
117	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.58074457
118	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.58010648
119	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.57203946
120	* PIAS1_25552417_ChIP-Seq_VCAP_Human	0.55952925
121	GATA1_22025678_ChIP-Seq_K562_Human	0.55630318
122	NCOR_22424771_ChIP-Seq_293T_Human	0.55038484
123	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.53260475
124	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.53158873
125	EGR1_19032775_ChIP-ChIP_M12_Human	0.52817073
126	* SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.52673850
127	* CBP_21632823_ChIP-Seq_H3396_Human	0.52649803
128	* AR_20517297_ChIP-Seq_VCAP_Human	0.52149714
129	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.52103071
130	BCAT_22108803_ChIP-Seq_LS180_Human	0.52078470
131	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.51896295
132	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.50646851
133	IRF1_19129219_ChIP-ChIP_H3396_Human	0.49944606
134	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.49848470
135	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.49004423
136	* FOXA1_25552417_ChIP-Seq_VCAP_Human	0.48347865
137	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.48312149
138	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.48237352
139	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.47985598
140	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.47963387
141	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.47899014
142	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.47855442
143	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.47538610
144	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.47358028
145	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.47247381
146	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.46525003
147	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.45926695
148	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.45908709
149	STAT1_17558387_ChIP-Seq_HELA_Human	0.45766850
150	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.45673360
151	ZNF263_19887448_ChIP-Seq_K562_Human	0.45269875
152	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.44013820
153	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.43836679
154	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.43802052
155	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.43770503
156	P53_21459846_ChIP-Seq_SAOS-2_Human	0.43714449
157	CEBPB_22108803_ChIP-Seq_LS180_Human	0.42290162
158	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.42164359
159	TAF2_19829295_ChIP-Seq_ESCs_Human	0.42066809
160	OCT4_20526341_ChIP-Seq_ESCs_Human	0.41663354
161	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.40941565
162	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.40214014
163	* CTCF_27219007_Chip-Seq_Bcells_Human	0.40163636
164	P300_19829295_ChIP-Seq_ESCs_Human	0.39997908
165	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.39979794
166	* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.39529379
167	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.38751879
168	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.38249239
169	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.38125994

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.29435497
2	MP0005360_urolithiasis	7.45171401
3	MP0005085_abnormal_gallbladder_physiolo	6.38887119
4	MP0005365_abnormal_bile_salt	5.93349536
5	MP0008875_abnormal_xenobiotic_pharmacok	5.12714149
6	MP0003806_abnormal_nucleotide_metabolis	4.32010662
7	MP0003252_abnormal_bile_duct	3.60881191
8	MP0010329_abnormal_lipoprotein_level	3.51692431
9	MP0009840_abnormal_foam_cell	3.41561544
10	MP0005083_abnormal_biliary_tract	3.16879013
11	MP0003195_calcinosis	2.98113229
12	MP0005332_abnormal_amino_acid	2.79528016
13	MP0002909_abnormal_adrenal_gland	2.77169258
14	MP0003122_maternal_imprinting	2.66085068
15	MP0000537_abnormal_urethra_morphology	2.52268532
16	MP0002653_abnormal_ependyma_morphology	2.48841305
17	MP0001666_abnormal_nutrient_absorption	2.44184590
18	MP0000566_synostosis	2.42651107
19	MP0003315_abnormal_perineum_morphology	2.41294337
20	MP0003123_paternal_imprinting	2.28632680
21	MP0004185_abnormal_adipocyte_glucose	2.16866940
22	MP0004019_abnormal_vitamin_homeostasis	2.14421475
23	MP0002118_abnormal_lipid_homeostasis	2.12427447
24	MP0003868_abnormal_feces_composition	2.01381969
25	MP0003191_abnormal_cellular_cholesterol	2.00403766
26	MP0000609_abnormal_liver_physiology	1.96877495
27	MP0003011_delayed_dark_adaptation	1.94202450
28	MP0004145_abnormal_muscle_electrophysio	1.89896163
29	MP0005666_abnormal_adipose_tissue	1.86723565
30	MP0001529_abnormal_vocalization	1.84503527
31	MP0004858_abnormal_nervous_system	1.83825949
32	MP0009697_abnormal_copulation	1.73877459
33	MP0005319_abnormal_enzyme/_coenzyme	1.70860880
34	MP0002138_abnormal_hepatobiliary_system	1.70244411
35	MP0005584_abnormal_enzyme/coenzyme_acti	1.62986495
36	MP0005451_abnormal_body_composition	1.59241110
37	MP0000778_abnormal_nervous_system	1.58951585
38	MP0003879_abnormal_hair_cell	1.54751556
39	MP0005645_abnormal_hypothalamus_physiol	1.51395783
40	MP0001984_abnormal_olfaction	1.48832497
41	* MP0001764_abnormal_homeostasis	1.45983468
42	MP0003878_abnormal_ear_physiology	1.43915870
43	MP0005377_hearing/vestibular/ear_phenot	1.43915870
44	MP0003121_genomic_imprinting	1.39845016
45	MP0005394_taste/olfaction_phenotype	1.39841012
46	MP0005499_abnormal_olfactory_system	1.39841012
47	MP0005423_abnormal_somatic_nervous	1.36679158
48	MP0003787_abnormal_imprinting	1.35937039
49	MP0002557_abnormal_social/conspecific_i	1.34150185
50	MP0003136_yellow_coat_color	1.33533639
51	MP0003656_abnormal_erythrocyte_physiolo	1.30990539
52	MP0003186_abnormal_redox_activity	1.30447444
53	MP0003942_abnormal_urinary_system	1.26111316
54	MP0000604_amyloidosis	1.23999133
55	MP0002249_abnormal_larynx_morphology	1.23396831
56	MP0008789_abnormal_olfactory_epithelium	1.22515172
57	MP0002009_preneoplasia	1.16434430
58	MP0006292_abnormal_olfactory_placode	1.15919555
59	MP0001485_abnormal_pinna_reflex	1.14800235
60	MP0004133_heterotaxia	1.14421133
61	MP0005647_abnormal_sex_gland	1.11982530
62	MP0003283_abnormal_digestive_organ	1.10604584
63	MP0009643_abnormal_urine_homeostasis	1.10313135
64	MP0000631_abnormal_neuroendocrine_gland	1.08442724
65	MP0005375_adipose_tissue_phenotype	1.07984224
66	MP0003329_amyloid_beta_deposits	1.07152587
67	MP0000026_abnormal_inner_ear	1.06893130
68	MP0000538_abnormal_urinary_bladder	1.06279078
69	MP0000955_abnormal_spinal_cord	1.06108379
70	MP0010030_abnormal_orbit_morphology	1.04598116
71	MP0009764_decreased_sensitivity_to	1.03354320
72	MP0002796_impaired_skin_barrier	1.00327642
73	MP0002234_abnormal_pharynx_morphology	1.00312072
74	MP0003690_abnormal_glial_cell	0.99397727
75	MP0003880_abnormal_central_pattern	0.98925926
76	MP0000598_abnormal_liver_morphology	0.98399395
77	MP0005636_abnormal_mineral_homeostasis	0.94125348
78	MP0004270_analgesia	0.93413094
79	MP0005408_hypopigmentation	0.91337253
80	MP0002638_abnormal_pupillary_reflex	0.90635141
81	MP0002736_abnormal_nociception_after	0.90542570
82	MP0004742_abnormal_vestibular_system	0.87310037
83	MP0002184_abnormal_innervation	0.87263999
84	MP0003938_abnormal_ear_development	0.86323794
85	MP0009763_increased_sensitivity_to	0.86082097
86	MP0002254_reproductive_system_inflammat	0.83455616
87	MP0009642_abnormal_blood_homeostasis	0.82692400
88	MP0002876_abnormal_thyroid_physiology	0.82512351
89	MP0005187_abnormal_penis_morphology	0.82247965
90	MP0010234_abnormal_vibrissa_follicle	0.82132979
91	MP0006036_abnormal_mitochondrial_physio	0.81581206
92	MP0002697_abnormal_eye_size	0.81337937
93	MP0001919_abnormal_reproductive_system	0.80990910
94	MP0009780_abnormal_chondrocyte_physiolo	0.80491753
95	MP0002735_abnormal_chemical_nociception	0.80442924
96	MP0001968_abnormal_touch/_nociception	0.79573437
97	MP0002160_abnormal_reproductive_system	0.79269552
98	MP0008995_early_reproductive_senescence	0.79243964
99	MP0000534_abnormal_ureter_morphology	0.79124717
100	MP0004859_abnormal_synaptic_plasticity	0.78599664
101	MP0001944_abnormal_pancreas_morphology	0.78246288
102	MP0002078_abnormal_glucose_homeostasis	0.76764748
103	MP0002734_abnormal_mechanical_nocicepti	0.75384089
104	MP0003635_abnormal_synaptic_transmissio	0.75330080
105	MP0009765_abnormal_xenobiotic_induced	0.74621304
106	MP0002063_abnormal_learning/memory/cond	0.74605620
107	MP0002572_abnormal_emotion/affect_behav	0.74297968
108	MP0005084_abnormal_gallbladder_morpholo	0.74214920
109	MP0008469_abnormal_protein_level	0.74187472
110	MP0000639_abnormal_adrenal_gland	0.73949058
111	MP0004233_abnormal_muscle_weight	0.73767313
112	MP0000647_abnormal_sebaceous_gland	0.72960012
113	MP0001905_abnormal_dopamine_level	0.72833938
114	MP0001188_hyperpigmentation	0.72779820
115	* MP0005376_homeostasis/metabolism_phenot	0.72755242
116	MP0005535_abnormal_body_temperature	0.72446191
117	MP0002152_abnormal_brain_morphology	0.72170596
118	MP0001661_extended_life_span	0.72086686
119	MP0002970_abnormal_white_adipose	0.72067422
120	MP0001486_abnormal_startle_reflex	0.71942711
121	MP0005220_abnormal_exocrine_pancreas	0.70729952
122	MP0005334_abnormal_fat_pad	0.69522694
123	MP0002971_abnormal_brown_adipose	0.63759359
124	MP0009053_abnormal_anal_canal	0.59189846
125	MP0006035_abnormal_mitochondrial_morpho	0.57519772
126	MP0005448_abnormal_energy_balance	0.57487439
127	MP0005266_abnormal_metabolism	0.57312508
128	MP0004142_abnormal_muscle_tone	0.55659774
129	MP0003718_maternal_effect	0.55637383
130	MP0008874_decreased_physiological_sensi	0.55239247
131	MP0004381_abnormal_hair_follicle	0.53648308
132	MP0005670_abnormal_white_adipose	0.53543281
133	MP0002822_catalepsy	0.52810191
134	MP0010368_abnormal_lymphatic_system	0.52089075
135	MP0001756_abnormal_urination	0.51744814
136	MP0006276_abnormal_autonomic_nervous	0.50151387
137	MP0008872_abnormal_physiological_respon	0.50027384
138	MP0009379_abnormal_foot_pigmentation	0.48385914
139	MP0003638_abnormal_response/metabolism_	0.46858364
140	MP0000920_abnormal_myelination	0.45784229
141	MP0004782_abnormal_surfactant_physiolog	0.45022636
142	MP0004130_abnormal_muscle_cell	0.44022754
143	MP0005395_other_phenotype	0.43859826
144	MP0003075_altered_response_to	0.43682353
145	MP0003953_abnormal_hormone_level	0.43639540
146	MP0000579_abnormal_nail_morphology	0.38932239
147	MP0001324_abnormal_eye_pigmentation	0.36972937
148	MP0005248_abnormal_Harderian_gland	0.36821917
149	MP0004043_abnormal_pH_regulation	0.36167667
150	MP0003632_abnormal_nervous_system	0.34942636
151	MP0005551_abnormal_eye_electrophysiolog	0.34883680
152	MP0003705_abnormal_hypodermis_morpholog	0.34698333
153	MP0004883_abnormal_blood_vessel	0.34615511
154	MP0000230_abnormal_systemic_arterial	0.33535055
155	MP0002090_abnormal_vision	0.32995053
156	MP0009672_abnormal_birth_weight	0.31944575
157	MP0005166_decreased_susceptibility_to	0.30696015
158	MP0008873_increased_physiological_sensi	0.29790627
159	MP0002928_abnormal_bile_duct	0.28932902
160	MP0002136_abnormal_kidney_physiology	0.28848343
161	MP0002069_abnormal_eating/drinking_beha	0.28703948
162	MP0009384_cardiac_valve_regurgitation	0.28433821
163	MP0005464_abnormal_platelet_physiology	0.27574830
164	MP0003631_nervous_system_phenotype	0.27434795
165	MP0003633_abnormal_nervous_system	0.26461523
166	MP0002132_abnormal_respiratory_system	0.26279401
167	MP0001881_abnormal_mammary_gland	0.25494412
168	MP0003959_abnormal_lean_body	0.25451489
169	MP0005646_abnormal_pituitary_gland	0.24587518
170	MP0005164_abnormal_response_to	0.24516075
171	MP0002229_neurodegeneration	0.24470835

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.49720276
2	Intrahepatic cholestasis (HP:0001406)	7.48587088
3	Deep venous thrombosis (HP:0002625)	7.08964676
4	Prolonged partial thromboplastin time (HP:0003645)	6.47660089
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.38751116
6	Xanthomatosis (HP:0000991)	6.18330577
7	Hypobetalipoproteinemia (HP:0003563)	6.17852194
8	Hyperlipoproteinemia (HP:0010980)	5.46909983
9	Complement deficiency (HP:0004431)	4.90305940
10	Joint hemorrhage (HP:0005261)	4.64642171
11	Hypolipoproteinemia (HP:0010981)	4.54419678
12	Hyperglycinemia (HP:0002154)	4.42259404
13	Hyperammonemia (HP:0001987)	4.37255137
14	Epidermoid cyst (HP:0200040)	4.35461164
15	Abnormality of methionine metabolism (HP:0010901)	4.33282226
16	Testicular atrophy (HP:0000029)	4.16078490
17	Fat malabsorption (HP:0002630)	4.15119044
18	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.14789188
19	Myokymia (HP:0002411)	4.13941448
20	Ketosis (HP:0001946)	4.11805887
21	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.09302273
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.07774434
23	Abnormality of the common coagulation pathway (HP:0010990)	4.04714198
24	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.96904750
25	Abnormality of serine family amino acid metabolism (HP:0010894)	3.94951369
26	Abnormality of glycine metabolism (HP:0010895)	3.94951369
27	Hypoalphalipoproteinemia (HP:0003233)	3.90428311
28	Hyperglycinuria (HP:0003108)	3.82673435
29	Conjugated hyperbilirubinemia (HP:0002908)	3.70733649
30	Abnormality of pyrimidine metabolism (HP:0004353)	3.53015184
31	Abnormality of complement system (HP:0005339)	3.53002185
32	Hypercholesterolemia (HP:0003124)	3.48896329
33	Hypoglycemic coma (HP:0001325)	3.47448127
34	Abnormality of the intrinsic pathway (HP:0010989)	3.45462584
35	Hyperbilirubinemia (HP:0002904)	3.30113446
36	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.26105198
37	Steatorrhea (HP:0002570)	3.17475791
38	Abnormality of fatty-acid metabolism (HP:0004359)	3.16850420
39	Abnormality of serum amino acid levels (HP:0003112)	3.03008203
40	Delayed CNS myelination (HP:0002188)	3.02873684
41	Ketoacidosis (HP:0001993)	2.90629875
42	Bifid scrotum (HP:0000048)	2.88832726
43	Enlarged penis (HP:0000040)	2.79541148
44	Abnormality of nucleobase metabolism (HP:0010932)	2.78151906
45	Spontaneous abortion (HP:0005268)	2.77922815
46	Cerebral edema (HP:0002181)	2.73858415
47	Lethargy (HP:0001254)	2.73291843
48	Hypochromic microcytic anemia (HP:0004840)	2.70676346
49	Metabolic acidosis (HP:0001942)	2.70074407
50	Hepatocellular carcinoma (HP:0001402)	2.68490868
51	Skin nodule (HP:0200036)	2.67852490
52	Oligomenorrhea (HP:0000876)	2.66808292
53	Growth hormone excess (HP:0000845)	2.66207619
54	Testicular neoplasm (HP:0010788)	2.63769201
55	Vascular calcification (HP:0004934)	2.55695926
56	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.53357400
57	Dicarboxylic aciduria (HP:0003215)	2.53357400
58	Amyloidosis (HP:0011034)	2.50435412
59	Acanthocytosis (HP:0001927)	2.50084924
60	Gonadotropin excess (HP:0000837)	2.48890900
61	Abnormal gallbladder morphology (HP:0012437)	2.48004441
62	Septate vagina (HP:0001153)	2.47388653
63	Abnormal gallbladder physiology (HP:0012438)	2.47242886
64	Cholecystitis (HP:0001082)	2.47242886
65	Abnormality of the axillary hair (HP:0100134)	2.45911152
66	Abnormality of secondary sexual hair (HP:0009888)	2.45911152
67	Irritability (HP:0000737)	2.45599322
68	Polyphagia (HP:0002591)	2.44891967
69	Myocardial infarction (HP:0001658)	2.44607661
70	Systemic lupus erythematosus (HP:0002725)	2.41406410
71	Hypoglycemic seizures (HP:0002173)	2.40950217
72	Abnormality of purine metabolism (HP:0004352)	2.40720266
73	Abnormal tarsal ossification (HP:0008369)	2.38345926
74	Mitral stenosis (HP:0001718)	2.34765106
75	Brushfield spots (HP:0001088)	2.34422911
76	Hyperpituitarism (HP:0010514)	2.32042775
77	Cholelithiasis (HP:0001081)	2.30399999
78	Neonatal onset (HP:0003623)	2.30014945
79	Partial duplication of thumb phalanx (HP:0009944)	2.29115903
80	Bronchomalacia (HP:0002780)	2.27721646
81	Abnormality of the aortic arch (HP:0012303)	2.24596048
82	Glomerulonephritis (HP:0000099)	2.22425107
83	Hypophosphatemic rickets (HP:0004912)	2.21573552
84	Malnutrition (HP:0004395)	2.20024052
85	Cardiovascular calcification (HP:0011915)	2.19725445
86	Male pseudohermaphroditism (HP:0000037)	2.18967836
87	Vomiting (HP:0002013)	2.18763360
88	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18272248
89	Abnormality of alanine metabolism (HP:0010916)	2.18272248
90	Hyperalaninemia (HP:0003348)	2.18272248
91	Renal salt wasting (HP:0000127)	2.17594170
92	Abnormality of carpal bone ossification (HP:0006257)	2.15600069
93	Enlarged kidneys (HP:0000105)	2.15520826
94	Gout (HP:0001997)	2.14803707
95	Opisthotonus (HP:0002179)	2.14128039
96	Abnormality of the gallbladder (HP:0005264)	2.13707876
97	Hyperthyroidism (HP:0000836)	2.13130813
98	Sensorimotor neuropathy (HP:0007141)	2.11570542
99	Spastic diplegia (HP:0001264)	2.09726023
100	Status epilepticus (HP:0002133)	2.09297812
101	Rickets (HP:0002748)	2.07524506
102	Recurrent gram-negative bacterial infections (HP:0005420)	2.06349928
103	Spastic paraparesis (HP:0002313)	2.00056202
104	Absent hair (HP:0002298)	1.99983973
105	Menorrhagia (HP:0000132)	1.98502395
106	Pancreatitis (HP:0001733)	1.98360149
107	Gingival bleeding (HP:0000225)	1.98356744
108	Poor suck (HP:0002033)	1.93761409
109	Concave nail (HP:0001598)	1.92690271
110	Neurofibrillary tangles (HP:0002185)	1.92601282
111	Late onset (HP:0003584)	1.91706611
112	Epiphyseal stippling (HP:0010655)	1.91163771
113	Alkalosis (HP:0001948)	1.90566949
114	Hyperinsulinemic hypoglycemia (HP:0000825)	1.88681691
115	Increased muscle lipid content (HP:0009058)	1.88327227
116	Abnormality of vitamin metabolism (HP:0100508)	1.86997902
117	Acute encephalopathy (HP:0006846)	1.85528732
118	Generalized aminoaciduria (HP:0002909)	1.85178218
119	Partial duplication of the phalanx of hand (HP:0009999)	1.84807272
120	Abnormality of the phalanges of the hallux (HP:0010057)	1.84264835
121	11 pairs of ribs (HP:0000878)	1.83539054
122	Flat acetabular roof (HP:0003180)	1.83457699
123	Precocious puberty (HP:0000826)	1.83274424
124	Choanal stenosis (HP:0000452)	1.82124390
125	Increased serum pyruvate (HP:0003542)	1.81937593
126	Abnormality of glycolysis (HP:0004366)	1.81937593
127	Abnormality of the parathyroid morphology (HP:0011766)	1.81371401
128	Poikilocytosis (HP:0004447)	1.80401096
129	Renal dysplasia (HP:0000110)	1.80107132
130	Hemorrhage of the eye (HP:0011885)	1.79225983
131	Glycosuria (HP:0003076)	1.78043743
132	Abnormality of urine glucose concentration (HP:0011016)	1.78043743
133	Hypoplastic pelvis (HP:0008839)	1.77975107
134	Elevated hepatic transaminases (HP:0002910)	1.77960290
135	Esophageal varix (HP:0002040)	1.76355346
136	Hepatoblastoma (HP:0002884)	1.76256455
137	Hydroxyprolinuria (HP:0003080)	1.76111520
138	Abnormality of proline metabolism (HP:0010907)	1.76111520
139	Hyperventilation (HP:0002883)	1.75591669
140	Renal cortical cysts (HP:0000803)	1.75542141
141	Decreased circulating renin level (HP:0003351)	1.75502395
142	Cerebral palsy (HP:0100021)	1.69671273
143	Calf muscle hypertrophy (HP:0008981)	1.69213335
144	Abnormal urine phosphate concentration (HP:0012599)	1.68126755
145	Abnormal hand bone ossification (HP:0010660)	1.68051513
146	Lymphangioma (HP:0100764)	1.67859364
147	Synostosis involving the elbow (HP:0003938)	1.67716584
148	Humeroradial synostosis (HP:0003041)	1.67716584
149	Short femoral neck (HP:0100864)	1.66897728
150	Abnormal epiphyseal ossification (HP:0010656)	1.65720624
151	Gait imbalance (HP:0002141)	1.64095270
152	Azoospermia (HP:0000027)	1.64035871
153	Hepatic necrosis (HP:0002605)	1.63377005
154	Rib fusion (HP:0000902)	1.62643997
155	Generalized hypotonia (HP:0001290)	1.61043659
156	Abnormal sex determination (HP:0012244)	1.59156058
157	Sex reversal (HP:0012245)	1.59156058
158	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.56599346
159	Abnormal ossification of hand bones (HP:0005921)	1.55512849
160	Bifid tongue (HP:0010297)	1.54228167
161	Aplasia/hypoplasia of the femur (HP:0005613)	1.53098602
162	Pachygyria (HP:0001302)	1.52552094
163	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.52386800
164	Scrotal hypoplasia (HP:0000046)	1.51937845
165	Hyperphosphaturia (HP:0003109)	1.51423338
166	Septo-optic dysplasia (HP:0100842)	1.49442985
167	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.48974907
168	Cortical dysplasia (HP:0002539)	1.46496291
169	Hypoplasia of the uterus (HP:0000013)	1.45814979
170	Hepatocellular necrosis (HP:0001404)	1.45573017
171	Turricephaly (HP:0000262)	1.43134844
172	Maternal diabetes (HP:0009800)	1.42686772
173	Self-mutilation (HP:0000742)	1.42035795
174	Flattened epiphyses (HP:0003071)	1.41244310

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	6.28925203
2	SIK1	4.71169240
3	CAMK1D	4.20789651
4	TRIB3	4.17751881
5	FGFR4	3.96813248
6	ERBB4	3.21703374
7	CAMK1G	3.14150857
8	TNK2	3.05571531
9	CASK	3.05379805
10	ERN1	2.99520649
11	INSRR	2.90336155
12	TAOK1	2.83070744
13	PIM2	2.77848642
14	PRKD3	2.70587897
15	TAOK3	2.47641094
16	MAP2K4	2.34327948
17	EPHA2	2.20135934
18	EEF2K	1.95961011
19	PKN2	1.90697850
20	MST1R	1.89669748
21	EPHB1	1.77517308
22	FER	1.71975459
23	MARK2	1.69726681
24	MAPK11	1.67252115
25	PBK	1.63657104
26	DAPK2	1.63056775
27	PIK3CG	1.58997671
28	EPHA4	1.57842760
29	PRKD2	1.55640214
30	TESK1	1.54026872
31	ARAF	1.51429103
32	TESK2	1.50816077
33	FGFR2	1.50690225
34	ABL2	1.44527883
35	SMG1	1.38771319
36	PKN1	1.38593942
37	PRKCI	1.38529162
38	MAPKAPK3	1.31557157
39	STK38L	1.30206101
40	GRK6	1.27064795
41	MAPK15	1.22712992
42	CSNK1G3	1.19907940
43	MET	1.13226649
44	STK39	1.12831477
45	MAPK4	1.12756831
46	CSNK1G1	1.11580304
47	PRKCZ	1.10016784
48	ERBB2	1.08789833
49	CAMK2G	1.07903771
50	FLT3	1.07686389
51	ILK	1.04164145
52	MINK1	1.03222608
53	CSNK1G2	1.03158887
54	VRK2	1.02256929
55	CAMK1	1.01645864
56	SGK494	1.00620095
57	SGK223	1.00620095
58	IRAK2	0.98934430
59	MARK1	0.94869806
60	PRKCG	0.94831640
61	NTRK1	0.91460202
62	CSNK1A1L	0.88830480
63	JAK2	0.87705147
64	MAPK12	0.87138699
65	TNIK	0.86668864
66	CDK7	0.86253559
67	IRAK1	0.86039302
68	OXSR1	0.85844875
69	NTRK3	0.85573421
70	NEK9	0.84827282
71	DYRK2	0.83501865
72	MTOR	0.83236285
73	AKT3	0.83175539
74	PRKAA2	0.81744102
75	SIK3	0.81366966
76	PRKACG	0.79817577
77	AURKA	0.78853840
78	MAP2K6	0.78685432
79	TAF1	0.77614288
80	DYRK3	0.77309611
81	EPHA3	0.76735054
82	TYK2	0.76550413
83	LRRK2	0.75329214
84	MAP3K7	0.72800541
85	GSK3A	0.72159415
86	PINK1	0.71650370
87	TYRO3	0.71300713
88	GRK1	0.71136744
89	AKT2	0.70608010
90	MUSK	0.70435188
91	PRKCQ	0.68896002
92	LATS1	0.68239721
93	RPS6KA2	0.66453800
94	ADRBK2	0.64499220
95	CAMKK1	0.64438810
96	SGK2	0.63736976
97	PRKD1	0.63163666
98	DYRK1B	0.59432765
99	MAP3K4	0.58910993
100	LIMK1	0.58232030
101	PAK3	0.57558074
102	BCR	0.57413240
103	FRK	0.56713520
104	DAPK3	0.56316512
105	MAP2K7	0.55650788
106	MAP3K14	0.53780116
107	NTRK2	0.53694973
108	MAPK7	0.53364702
109	GRK5	0.53303096
110	CAMK2A	0.52886579
111	PTK6	0.51742772
112	PRKAA1	0.51615187
113	CDK9	0.50707084
114	MAP2K2	0.49896862
115	SGK3	0.48920681
116	RPS6KB2	0.48523459
117	PDPK1	0.48499649
118	CDK5	0.47237945
119	CAMK2B	0.47037191
120	SCYL2	0.46841978
121	STK16	0.45688057
122	PTK2	0.43902318
123	WNK4	0.43767083
124	RIPK1	0.42918048
125	TAOK2	0.41970901
126	STK11	0.41967385
127	CSNK1A1	0.41783030
128	GRK7	0.41097018
129	MAPK13	0.40512955
130	CSK	0.40076540
131	ICK	0.39589858
132	CSNK1E	0.39173606
133	PRKACA	0.39099777
134	TBK1	0.38243614
135	TIE1	0.37843231
136	PRKCA	0.37841841
137	MAP3K11	0.37815591
138	IGF1R	0.37693114
139	MAP4K2	0.37370651
140	EPHB2	0.36687712
141	RET	0.36657607
142	KDR	0.34868899
143	MAP2K1	0.33659812
144	JAK1	0.32920884
145	BRAF	0.32913452
146	LMTK2	0.32489488
147	ADRBK1	0.32200261
148	PHKG1	0.30500636
149	PHKG2	0.30500636
150	PRKG1	0.30398716
151	CAMK4	0.28683360

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.43435010
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.25500704
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.18410076
4	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.05194298
5	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.04574729
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.88842917
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.63057576
8	Complement and coagulation cascades_Homo sapiens_hsa04610	2.58626266
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.58035479
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.51697041
11	Fatty acid degradation_Homo sapiens_hsa00071	2.43146393
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.40797014
13	Butanoate metabolism_Homo sapiens_hsa00650	2.36753218
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.23993952
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.21625218
16	Peroxisome_Homo sapiens_hsa04146	2.15717359
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.12783800
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.00799658
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.99117647
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.99007319
21	* Steroid biosynthesis_Homo sapiens_hsa00100	1.95616201
22	Histidine metabolism_Homo sapiens_hsa00340	1.93317197
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.92645600
24	Propanoate metabolism_Homo sapiens_hsa00640	1.90440202
25	Fatty acid elongation_Homo sapiens_hsa00062	1.79387928
26	PPAR signaling pathway_Homo sapiens_hsa03320	1.77912696
27	Retinol metabolism_Homo sapiens_hsa00830	1.74172784
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.66090169
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.65089123
30	beta-Alanine metabolism_Homo sapiens_hsa00410	1.64566968
31	Caffeine metabolism_Homo sapiens_hsa00232	1.57869815
32	Sulfur metabolism_Homo sapiens_hsa00920	1.55272303
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.54991230
34	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.54279405
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.53790142
36	Phenylalanine metabolism_Homo sapiens_hsa00360	1.48784206
37	Bile secretion_Homo sapiens_hsa04976	1.44812907
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.43430277
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.37792511
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.36593786
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.31387584
42	Folate biosynthesis_Homo sapiens_hsa00790	1.26920234
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.23458325
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16509600
45	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.15430729
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12209382
47	ABC transporters_Homo sapiens_hsa02010	1.12175342
48	Fat digestion and absorption_Homo sapiens_hsa04975	1.11476797
49	Sulfur relay system_Homo sapiens_hsa04122	1.08259319
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.05847276
51	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04786189
52	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.04769061
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.02005532
54	Carbon metabolism_Homo sapiens_hsa01200	0.99518490
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97512089
56	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.90867859
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.87640339
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86868029
59	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.85808817
60	Ribosome_Homo sapiens_hsa03010	0.84782895
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.84745429
62	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.81236340
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78745315
64	Glutathione metabolism_Homo sapiens_hsa00480	0.73427158
65	Huntingtons disease_Homo sapiens_hsa05016	0.73164753
66	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.69362193
67	Notch signaling pathway_Homo sapiens_hsa04330	0.68712639
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68677773
69	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.67791277
70	Lysine degradation_Homo sapiens_hsa00310	0.64706866
71	One carbon pool by folate_Homo sapiens_hsa00670	0.62064099
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61463426
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.59345468
74	Nicotine addiction_Homo sapiens_hsa05033	0.59098560
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.57496041
76	* Metabolic pathways_Homo sapiens_hsa01100	0.53867818
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.53532904
78	Axon guidance_Homo sapiens_hsa04360	0.51589358
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50358018
80	Pentose phosphate pathway_Homo sapiens_hsa00030	0.49285186
81	Cocaine addiction_Homo sapiens_hsa05030	0.48933524
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45454998
83	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.45212245
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40892966
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37837370
86	Prion diseases_Homo sapiens_hsa05020	0.37085027
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36713940
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.33993580
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29899249
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.26920507
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.26116756
92	Serotonergic synapse_Homo sapiens_hsa04726	0.25550144
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25194105
94	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.20886669
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.20428463
96	Galactose metabolism_Homo sapiens_hsa00052	0.18877892
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17895786
98	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.15433289
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.14181566
100	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.09793203
101	Insulin resistance_Homo sapiens_hsa04931	0.05855368
102	Oxidative phosphorylation_Homo sapiens_hsa00190	0.05816240
103	Ether lipid metabolism_Homo sapiens_hsa00565	0.05001746
104	Mineral absorption_Homo sapiens_hsa04978	-0.2214053
105	Renin-angiotensin system_Homo sapiens_hsa04614	-0.2100801
106	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2067965
107	GABAergic synapse_Homo sapiens_hsa04727	-0.2033051
108	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	-0.1973963
109	Hepatitis C_Homo sapiens_hsa05160	-0.1927526
110	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1907161
111	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1879702
112	Protein export_Homo sapiens_hsa03060	-0.1593409
113	African trypanosomiasis_Homo sapiens_hsa05143	-0.1140662
114	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0932012
115	Parkinsons disease_Homo sapiens_hsa05012	-0.0796029
116	Alzheimers disease_Homo sapiens_hsa05010	-0.0767298
117	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.0645019
118	Regulation of autophagy_Homo sapiens_hsa04140	-0.0631331
119	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	-0.0616586
120	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0586299
121	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.0534985
122	Glucagon signaling pathway_Homo sapiens_hsa04922	-0.0358302
123	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0089303

TM7SF2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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