TM7SF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)9.30497978
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)8.86104618
3antigen processing and presentation of endogenous antigen (GO:0019883)7.35125385
4L-phenylalanine catabolic process (GO:0006559)7.09696900
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.09696900
6L-phenylalanine metabolic process (GO:0006558)6.71086598
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.71086598
8hemidesmosome assembly (GO:0031581)6.09860348
9aromatic amino acid family catabolic process (GO:0009074)5.63237739
10glyoxylate metabolic process (GO:0046487)5.60975640
11alpha-linolenic acid metabolic process (GO:0036109)5.35069304
12axon ensheathment in central nervous system (GO:0032291)5.10802792
13central nervous system myelination (GO:0022010)5.10802792
14serine family amino acid biosynthetic process (GO:0009070)5.07712874
15cysteine metabolic process (GO:0006534)5.06717713
16sulfur amino acid catabolic process (GO:0000098)5.02701675
17fatty acid elongation (GO:0030497)4.99854551
18L-serine metabolic process (GO:0006563)4.95551103
19heme transport (GO:0015886)4.92748012
20bile acid biosynthetic process (GO:0006699)4.83394292
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.60218362
22very long-chain fatty acid metabolic process (GO:0000038)4.45413614
23tyrosine metabolic process (GO:0006570)4.40498712
24homocysteine metabolic process (GO:0050667)4.40441626
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.37746714
26diol metabolic process (GO:0034311)4.35737531
27serine family amino acid metabolic process (GO:0009069)4.35430776
28tryptophan catabolic process (GO:0006569)4.31931981
29indole-containing compound catabolic process (GO:0042436)4.31931981
30indolalkylamine catabolic process (GO:0046218)4.31931981
31lysine metabolic process (GO:0006553)4.24440115
32lysine catabolic process (GO:0006554)4.24440115
33kynurenine metabolic process (GO:0070189)4.24019730
34DNA unwinding involved in DNA replication (GO:0006268)4.19495497
35tryptophan metabolic process (GO:0006568)4.18560092
36aromatic amino acid family metabolic process (GO:0009072)4.18141485
37protein carboxylation (GO:0018214)4.17448402
38peptidyl-glutamic acid carboxylation (GO:0017187)4.17448402
39glycine metabolic process (GO:0006544)4.13474949
40bile acid metabolic process (GO:0008206)4.07878892
41regulation of protein activation cascade (GO:2000257)4.05336728
42ethanol oxidation (GO:0006069)4.02936135
43sphingoid metabolic process (GO:0046519)4.02259240
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01813321
45branched-chain amino acid catabolic process (GO:0009083)3.99760558
46high-density lipoprotein particle remodeling (GO:0034375)3.96693575
47dopamine transport (GO:0015872)3.94752727
48mRNA splice site selection (GO:0006376)3.94380258
49serine family amino acid catabolic process (GO:0009071)3.93244303
50aspartate family amino acid catabolic process (GO:0009068)3.91568513
51short-chain fatty acid metabolic process (GO:0046459)3.89445012
52alpha-amino acid catabolic process (GO:1901606)3.88443743
53complement activation, alternative pathway (GO:0006957)3.85952565
54regulation of complement activation (GO:0030449)3.85845984
55cholesterol biosynthetic process (GO:0006695)3.83061749
56negative regulation of fibrinolysis (GO:0051918)3.80039257
57imidazole-containing compound metabolic process (GO:0052803)3.76402713
58drug transmembrane transport (GO:0006855)3.75746297
59acetyl-CoA metabolic process (GO:0006084)3.75541144
60amino-acid betaine metabolic process (GO:0006577)3.75523940
61cellular amino acid catabolic process (GO:0009063)3.75463514
62cellular modified amino acid catabolic process (GO:0042219)3.74528772
63coenzyme catabolic process (GO:0009109)3.74487012
64response to methylmercury (GO:0051597)3.72444053
65fatty-acyl-CoA biosynthetic process (GO:0046949)3.70163116
66regulation of fibrinolysis (GO:0051917)3.67228643
67urea metabolic process (GO:0019627)3.62669185
68urea cycle (GO:0000050)3.62669185
69glutamate metabolic process (GO:0006536)3.61980306
70long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.61644336
71iron coordination entity transport (GO:1901678)3.57374361
72trophectodermal cell differentiation (GO:0001829)3.56484542
73cellular ketone body metabolic process (GO:0046950)3.55592027
74iron ion import (GO:0097286)3.53823757
75polyketide metabolic process (GO:0030638)3.52177777
76doxorubicin metabolic process (GO:0044598)3.52177777
77daunorubicin metabolic process (GO:0044597)3.52177777
78branched-chain amino acid metabolic process (GO:0009081)3.52175865
79protein-lipid complex remodeling (GO:0034368)3.52040343
80macromolecular complex remodeling (GO:0034367)3.52040343
81plasma lipoprotein particle remodeling (GO:0034369)3.52040343
82reverse cholesterol transport (GO:0043691)3.50664627
83regulation of cholesterol biosynthetic process (GO:0045540)3.50157558
84regulation of cholesterol metabolic process (GO:0090181)3.49442336
85response to mercury ion (GO:0046689)3.48955284
86ribosomal small subunit assembly (GO:0000028)3.45225268
87very-low-density lipoprotein particle assembly (GO:0034379)3.43742922
88thioester biosynthetic process (GO:0035384)3.43121118
89acyl-CoA biosynthetic process (GO:0071616)3.43121118
90intra-S DNA damage checkpoint (GO:0031573)3.42857158
91response to nitrosative stress (GO:0051409)3.41307319
92ketone body metabolic process (GO:1902224)3.40294194
93acyl-CoA metabolic process (GO:0006637)3.40064465
94thioester metabolic process (GO:0035383)3.40064465
95aldehyde catabolic process (GO:0046185)3.38835351
96regulation of cholesterol esterification (GO:0010872)3.38357642
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38199126
98fatty-acyl-CoA metabolic process (GO:0035337)3.35251274
99nitrogen cycle metabolic process (GO:0071941)3.34962564
100plasma lipoprotein particle clearance (GO:0034381)3.33996997
101NADPH regeneration (GO:0006740)3.33841786
102drug metabolic process (GO:0017144)3.31989090
103cofactor catabolic process (GO:0051187)3.31262465
104DNA integration (GO:0015074)3.30532949
105regulation of triglyceride catabolic process (GO:0010896)3.30465616
106cellular glucuronidation (GO:0052695)3.30244796
107carboxylic acid catabolic process (GO:0046395)3.29873024
108organic acid catabolic process (GO:0016054)3.29873024
109fatty acid beta-oxidation (GO:0006635)3.29156452
110sterol biosynthetic process (GO:0016126)3.28634912
111opsonization (GO:0008228)3.28256870
112low-density lipoprotein particle remodeling (GO:0034374)3.28244907
113fatty acid oxidation (GO:0019395)3.26907196
114negative regulation of sterol transport (GO:0032372)3.26479236
115negative regulation of cholesterol transport (GO:0032375)3.26479236
116viral transcription (GO:0019083)3.25151097
117aminoglycoside antibiotic metabolic process (GO:0030647)3.24531233
118killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.23542960
119disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.23542960
120myelin maintenance (GO:0043217)3.22616562
121lipid oxidation (GO:0034440)3.19879548
122blood coagulation, intrinsic pathway (GO:0007597)3.19721262
123cholesterol efflux (GO:0033344)3.18630344
124pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.17196713
125translational termination (GO:0006415)3.15089614
126protein retention in ER lumen (GO:0006621)3.15072285
127hormone catabolic process (GO:0042447)3.09440653
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06539229
129G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.06048678
130response to folic acid (GO:0051593)3.01683576
131toxin transport (GO:1901998)3.01660770
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01462351
133pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.98710341
134translational elongation (GO:0006414)2.98553495
135DNA-dependent DNA replication (GO:0006261)2.96798663
136auditory receptor cell differentiation (GO:0042491)2.95609051
137cotranslational protein targeting to membrane (GO:0006613)2.92062101
138heart trabecula morphogenesis (GO:0061384)2.91989118
139positive regulation of response to tumor cell (GO:0002836)2.91091943
140positive regulation of immune response to tumor cell (GO:0002839)2.91091943
141regulation of immune response to tumor cell (GO:0002837)2.91091943
142regulation of response to tumor cell (GO:0002834)2.91091943
143skeletal muscle tissue regeneration (GO:0043403)2.90131837
144receptor recycling (GO:0001881)2.89961103
145desmosome organization (GO:0002934)2.88301577
146protein targeting to ER (GO:0045047)2.87489672
147protein localization to endoplasmic reticulum (GO:0070972)2.82659314
148exogenous drug catabolic process (GO:0042738)2.80371735
149calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.77214280
150regulation of early endosome to late endosome transport (GO:2000641)2.77125149
151establishment of protein localization to endoplasmic reticulum (GO:0072599)2.75271522
152positive regulation of icosanoid secretion (GO:0032305)2.71681821
153zinc ion transmembrane transport (GO:0071577)2.66198401
154pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.64148011
155ribosomal small subunit biogenesis (GO:0042274)2.63995304
156drug catabolic process (GO:0042737)2.62777762
157nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60825454
158uronic acid metabolic process (GO:0006063)2.60038109
159glucuronate metabolic process (GO:0019585)2.60038109
160hepatocyte differentiation (GO:0070365)2.57595939
161fibrinolysis (GO:0042730)2.54746124
162gap junction assembly (GO:0016264)2.51850125
163ER overload response (GO:0006983)2.50152493
164proline biosynthetic process (GO:0006561)2.48909510
165blood vessel maturation (GO:0001955)2.48742036
166viral life cycle (GO:0019058)2.47307002
167hyaluronan catabolic process (GO:0030214)2.46299267
168trabecula morphogenesis (GO:0061383)2.45144721
169purine ribonucleotide transport (GO:0015868)2.44397108
170regulation of icosanoid secretion (GO:0032303)2.40122639
171monoamine transport (GO:0015844)2.38990625
172heme biosynthetic process (GO:0006783)2.36103953
173definitive hemopoiesis (GO:0060216)2.34902268
174cell adhesion mediated by integrin (GO:0033627)2.33387851
175deoxyribose phosphate catabolic process (GO:0046386)2.32972332
176peptidyl-asparagine modification (GO:0018196)2.30387252
177protein N-linked glycosylation via asparagine (GO:0018279)2.30308375
178intestinal cholesterol absorption (GO:0030299)2.29684612
179drug transport (GO:0015893)2.29380907
180cellular protein complex disassembly (GO:0043624)2.27679065
181tight junction assembly (GO:0070830)2.27613239
182protein N-linked glycosylation (GO:0006487)2.27438844
183regulation of translational fidelity (GO:0006450)2.25031216
184antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)10.0724413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.82425073
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.54629839
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.52537624
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.50826965
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.11577716
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.05726594
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.93294141
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.84604321
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.47405798
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.35350451
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.28182137
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74356288
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70260474
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65680056
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64039685
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20579826
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17057772
18E2F7_22180533_ChIP-Seq_HELA_Human2.00281550
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99651325
20VDR_21846776_ChIP-Seq_THP-1_Human1.99585625
21AR_21909140_ChIP-Seq_LNCAP_Human1.94613752
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93068104
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91286144
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87679265
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86553226
26* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82774691
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75481350
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73921205
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70450558
30* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68081464
31CLOCK_20551151_ChIP-Seq_293T_Human1.67104450
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65814714
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64828265
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56229033
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56229033
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56229033
37XRN2_22483619_ChIP-Seq_HELA_Human1.55461598
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55262630
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54395247
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51105203
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50487390
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49274511
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48858120
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.43636066
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43306236
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.40752576
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39860848
48TP53_22127205_ChIP-Seq_IMR90_Human1.36499582
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35592395
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.35230253
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35217683
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.34486343
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32131711
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32025485
55TTF2_22483619_ChIP-Seq_HELA_Human1.25776086
56* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25441352
57GATA1_22025678_ChIP-Seq_K562_Human1.24911221
58DCP1A_22483619_ChIP-Seq_HELA_Human1.24846919
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24798772
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24798772
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24173085
62ZNF263_19887448_ChIP-Seq_K562_Human1.23505405
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21481517
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21050847
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20947781
66* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18364431
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.17548026
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17457070
69GABP_19822575_ChIP-Seq_HepG2_Human1.17158229
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16425440
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16119296
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16048460
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15171946
74KDM5A_27292631_Chip-Seq_BREAST_Human1.13432753
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12745624
76VDR_24763502_ChIP-Seq_THP-1_Human1.12612423
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12554861
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12210138
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11980049
80TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11935613
81* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11133898
82HNF4A_19822575_ChIP-Seq_HepG2_Human1.10754930
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10225057
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09899891
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.09235009
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08699038
87* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07467835
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07285947
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07156924
90GATA6_25053715_ChIP-Seq_YYC3_Human1.06916979
91* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06629069
92MYC_22102868_ChIP-Seq_BL_Human1.06287623
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06030640
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05950262
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05586681
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.05160466
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04792751
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04311189
99HTT_18923047_ChIP-ChIP_STHdh_Human1.02336070
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02033929
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01746328
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01352175
103ATF3_27146783_Chip-Seq_COLON_Human1.00338874
104EOMES_21245162_ChIP-Seq_HESCs_Human1.00222966
105GATA1_19941826_ChIP-Seq_K562_Human1.00192424
106TFEB_21752829_ChIP-Seq_HELA_Human0.99395173
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.98372624
108* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97710661
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92715102
110* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91382933
111IRF1_19129219_ChIP-ChIP_H3396_Human0.91127305
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90881414
113FOXM1_23109430_ChIP-Seq_U2OS_Human0.90291957
114* VDR_23849224_ChIP-Seq_CD4+_Human0.90048976
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89595674
116CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89251899
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88953742
118KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88501797
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88198953
120SCL_19346495_ChIP-Seq_HPC-7_Human0.88169002
121* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87131366
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87029249
123RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85957617
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85754514
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.85473403
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85330780
127* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85160494
128ELK1_19687146_ChIP-ChIP_HELA_Human0.84587574
129BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83949526
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83450096
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83309403
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82375135
133GATA4_25053715_ChIP-Seq_YYC3_Human0.81509936
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80660397
135* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80559859
136* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.78619625
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77893629
138POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76685777
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.76079628
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75426514
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74409542
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.73335117
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72678104
144* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.71113019
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70545975
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70098356
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69258402
148NELFA_20434984_ChIP-Seq_ESCs_Mouse0.67596926
149* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66260741
150AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65859801
151SRF_21415370_ChIP-Seq_HL-1_Mouse0.65242837
152OCT4_18692474_ChIP-Seq_MEFs_Mouse0.64615557
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64030918
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64030918
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.63635456
156EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.62587012
157STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.62095597
158TRIM28_21343339_ChIP-Seq_HEK293_Human0.61210747
159* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.60475766
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.59922104
161TBX5_21415370_ChIP-Seq_HL-1_Mouse0.59494204
162KLF4_18555785_ChIP-Seq_MESCs_Mouse0.58951733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.51689335
2MP0005360_urolithiasis6.21076130
3MP0003806_abnormal_nucleotide_metabolis5.85496048
4MP0005085_abnormal_gallbladder_physiolo4.99183770
5MP0010234_abnormal_vibrissa_follicle4.62389457
6MP0005365_abnormal_bile_salt4.55553681
7MP0008875_abnormal_xenobiotic_pharmacok4.19031011
8MP0009840_abnormal_foam_cell3.71670835
9MP0003252_abnormal_bile_duct3.11731807
10MP0001835_abnormal_antigen_presentation3.05371001
11MP0003195_calcinosis2.90259102
12MP0005332_abnormal_amino_acid2.77126206
13MP0000920_abnormal_myelination2.75293379
14MP0010094_abnormal_chromosome_stability2.62171891
15MP0010329_abnormal_lipoprotein_level2.52441674
16MP0003690_abnormal_glial_cell2.30610560
17MP0002396_abnormal_hematopoietic_system2.29615851
18MP0003191_abnormal_cellular_cholesterol2.02415287
19MP0003186_abnormal_redox_activity1.97505619
20MP0003329_amyloid_beta_deposits1.95242432
21MP0003656_abnormal_erythrocyte_physiolo1.93072476
22MP0008438_abnormal_cutaneous_collagen1.90070925
23MP0002118_abnormal_lipid_homeostasis1.89317544
24MP0005408_hypopigmentation1.89041962
25MP0005083_abnormal_biliary_tract1.86801071
26MP0000858_altered_metastatic_potential1.85773111
27MP0001666_abnormal_nutrient_absorption1.82865874
28MP0004019_abnormal_vitamin_homeostasis1.73484476
29MP0004043_abnormal_pH_regulation1.68643292
30MP0005501_abnormal_skin_physiology1.68524621
31MP0000627_abnormal_mammary_gland1.68292425
32MP0003950_abnormal_plasma_membrane1.67204319
33MP0000609_abnormal_liver_physiology1.62980434
34MP0005464_abnormal_platelet_physiology1.62591979
35MP0002796_impaired_skin_barrier1.62269176
36MP0004885_abnormal_endolymph1.61250936
37MP0005584_abnormal_enzyme/coenzyme_acti1.59724211
38MP0005171_absent_coat_pigmentation1.58266242
39MP0009379_abnormal_foot_pigmentation1.57238600
40MP0000566_synostosis1.52413503
41MP0003011_delayed_dark_adaptation1.49842384
42MP0000762_abnormal_tongue_morphology1.47256792
43MP0009643_abnormal_urine_homeostasis1.44919409
44MP0001661_extended_life_span1.43739824
45MP0004147_increased_porphyrin_level1.43002295
46MP0005058_abnormal_lysosome_morphology1.41569519
47MP0000604_amyloidosis1.41381383
48MP0003136_yellow_coat_color1.41155699
49MP0005319_abnormal_enzyme/_coenzyme1.39210691
50MP0003566_abnormal_cell_adhesion1.38674553
51MP0002060_abnormal_skin_morphology1.38322359
52MP0003172_abnormal_lysosome_physiology1.36032289
53MP0003941_abnormal_skin_development1.34204955
54MP0001764_abnormal_homeostasis1.30253048
55MP0003868_abnormal_feces_composition1.27597638
56MP0002098_abnormal_vibrissa_morphology1.27422269
57MP0003705_abnormal_hypodermis_morpholog1.21771755
58MP0002234_abnormal_pharynx_morphology1.21085721
59MP0001545_abnormal_hematopoietic_system1.16384418
60MP0005397_hematopoietic_system_phenotyp1.16384418
61MP0003632_abnormal_nervous_system1.15884805
62MP0000490_abnormal_crypts_of1.14818235
63MP0002160_abnormal_reproductive_system1.10937515
64MP0004782_abnormal_surfactant_physiolog1.10720769
65MP0000383_abnormal_hair_follicle1.08642657
66MP0000013_abnormal_adipose_tissue1.04417866
67MP0005075_abnormal_melanosome_morpholog1.03604104
68MP0009384_cardiac_valve_regurgitation1.03314773
69MP0000462_abnormal_digestive_system1.03186398
70MP0003634_abnormal_glial_cell1.01355958
71MP0006036_abnormal_mitochondrial_physio1.00514471
72MP0000598_abnormal_liver_morphology1.00282030
73MP0010771_integument_phenotype0.99433766
74MP0009931_abnormal_skin_appearance0.98427253
75MP0005451_abnormal_body_composition0.98120683
76MP0004264_abnormal_extraembryonic_tissu0.97203433
77MP0001216_abnormal_epidermal_layer0.97019954
78MP0003111_abnormal_nucleus_morphology0.93504547
79MP0001881_abnormal_mammary_gland0.91721452
80MP0004808_abnormal_hematopoietic_stem0.90936180
81MP0005636_abnormal_mineral_homeostasis0.89908112
82MP0005174_abnormal_tail_pigmentation0.89251710
83MP0003183_abnormal_peptide_metabolism0.87536075
84MP0003315_abnormal_perineum_morphology0.87475466
85MP0001849_ear_inflammation0.86482076
86MP0003300_gastrointestinal_ulcer0.85999882
87MP0010307_abnormal_tumor_latency0.85071053
88MP0003453_abnormal_keratinocyte_physiol0.84884952
89MP0004381_abnormal_hair_follicle0.84503767
90MP0009053_abnormal_anal_canal0.84027966
91MP0006054_spinal_hemorrhage0.83654276
92MP0002138_abnormal_hepatobiliary_system0.82845640
93MP0005410_abnormal_fertilization0.82385986
94MP0000639_abnormal_adrenal_gland0.81903453
95MP0009763_increased_sensitivity_to0.81764265
96MP0005376_homeostasis/metabolism_phenot0.81642126
97MP0000613_abnormal_salivary_gland0.81357904
98MP0003075_altered_response_to0.77296244
99MP0005266_abnormal_metabolism0.77232162
100MP0004142_abnormal_muscle_tone0.75256588
101MP0004272_abnormal_basement_membrane0.74617107
102MP0009765_abnormal_xenobiotic_induced0.74312331
103MP0000358_abnormal_cell_content/0.73473179
104MP0003943_abnormal_hepatobiliary_system0.72746084
105MP0001485_abnormal_pinna_reflex0.71901355
106MP0003631_nervous_system_phenotype0.70980774
107MP0005389_reproductive_system_phenotype0.70890077
108MP0003567_abnormal_fetal_cardiomyocyte0.70708506
109MP0002229_neurodegeneration0.69797076
110MP0002295_abnormal_pulmonary_circulatio0.69700237
111MP0000678_abnormal_parathyroid_gland0.68776896
112MP0000350_abnormal_cell_proliferation0.68564929
113MP0005647_abnormal_sex_gland0.67293237
114MP0001348_abnormal_lacrimal_gland0.66945614
115MP0002089_abnormal_postnatal_growth/wei0.66506109
116MP0002095_abnormal_skin_pigmentation0.65298776
117MP0002090_abnormal_vision0.65297989
118MP0008932_abnormal_embryonic_tissue0.63935656
119MP0000747_muscle_weakness0.63594793
120MP0003633_abnormal_nervous_system0.61778507
121MP0001915_intracranial_hemorrhage0.59332538
122MP0003718_maternal_effect0.58643308
123MP0005220_abnormal_exocrine_pancreas0.56523528
124MP0009642_abnormal_blood_homeostasis0.53934915
125MP0001529_abnormal_vocalization0.53514445
126MP0008873_increased_physiological_sensi0.52612806
127MP0005395_other_phenotype0.52473703
128MP0004133_heterotaxia0.51798177
129MP0001756_abnormal_urination0.49058354
130MP0005023_abnormal_wound_healing0.47329629
131MP0000579_abnormal_nail_morphology0.46119300
132MP0010678_abnormal_skin_adnexa0.46081164
133MP0006035_abnormal_mitochondrial_morpho0.45914252
134MP0002136_abnormal_kidney_physiology0.45599842
135MP0000467_abnormal_esophagus_morphology0.45293482
136MP0003283_abnormal_digestive_organ0.44645647
137MP0002092_abnormal_eye_morphology0.44380158
138MP0001958_emphysema0.43552690
139MP0000465_gastrointestinal_hemorrhage0.42582692
140MP0001324_abnormal_eye_pigmentation0.41936197
141MP0008057_abnormal_DNA_replication0.41349802
142MP0008469_abnormal_protein_level0.40653116
143MP0000372_irregular_coat_pigmentation0.39024091
144MP0002078_abnormal_glucose_homeostasis0.38862513
145MP0009697_abnormal_copulation0.38861022
146MP0001293_anophthalmia0.38465826
147MP0002877_abnormal_melanocyte_morpholog0.37393150
148MP0001243_abnormal_dermal_layer0.37376861
149MP0009764_decreased_sensitivity_to0.36167368
150MP0005167_abnormal_blood-brain_barrier0.35969789
151MP0005164_abnormal_response_to0.35606242

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)7.54119960
2Chronic sinusitis (HP:0011109)6.40392117
3Intrahepatic cholestasis (HP:0001406)6.24515421
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.23106134
5Abnormality of the nasal mucosa (HP:0000433)6.19850597
6Deep venous thrombosis (HP:0002625)5.33390105
7Recurrent bronchitis (HP:0002837)5.07113691
8Xanthomatosis (HP:0000991)5.05381582
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.97148644
10Hypothermia (HP:0002045)4.78699973
11Hyperlipoproteinemia (HP:0010980)4.50132232
12Hypobetalipoproteinemia (HP:0003563)4.49963364
13Prolonged partial thromboplastin time (HP:0003645)4.47251924
14Thick nail (HP:0001805)4.35946044
15Onycholysis (HP:0001806)4.12066467
16Plantar hyperkeratosis (HP:0007556)4.05566276
17Hyperammonemia (HP:0001987)3.89869590
18Abnormality of serine family amino acid metabolism (HP:0010894)3.87994771
19Abnormality of glycine metabolism (HP:0010895)3.87994771
20Ketosis (HP:0001946)3.85589633
21Abnormality of methionine metabolism (HP:0010901)3.83372562
22Hypoglycemic coma (HP:0001325)3.77981905
23Abnormal rod and cone electroretinograms (HP:0008323)3.77897236
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.75382697
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.68416428
26Neurofibrillary tangles (HP:0002185)3.68380642
27Delayed CNS myelination (HP:0002188)3.47564226
28Hyperglycinemia (HP:0002154)3.38003938
29Complement deficiency (HP:0004431)3.33950887
30Hyperglycinuria (HP:0003108)3.32291307
31Milia (HP:0001056)3.32116020
32Fragile nails (HP:0001808)3.31540361
33Abnormality of fatty-acid metabolism (HP:0004359)3.29047049
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28479743
35Palmoplantar hyperkeratosis (HP:0000972)3.28038563
36Abnormality of the common coagulation pathway (HP:0010990)3.26394924
37Hypolipoproteinemia (HP:0010981)3.24818919
38Fat malabsorption (HP:0002630)3.23894214
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.18901934
40Degeneration of the lateral corticospinal tracts (HP:0002314)3.18901934
41Abnormality of pyrimidine metabolism (HP:0004353)3.18694524
42Acute lymphatic leukemia (HP:0006721)3.17752027
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.17274044
44Periodontitis (HP:0000704)3.10688963
45Palmar hyperkeratosis (HP:0010765)3.07325360
46Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05935349
47Epidermoid cyst (HP:0200040)3.05807125
48Joint hemorrhage (HP:0005261)3.03847398
49Abnormality of glycolipid metabolism (HP:0010969)2.99195500
50Abnormality of liposaccharide metabolism (HP:0010968)2.99195500
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.99195500
52Pustule (HP:0200039)2.93779642
53Amyloidosis (HP:0011034)2.92178257
54Abnormality of the intrinsic pathway (HP:0010989)2.88995653
55Flattened epiphyses (HP:0003071)2.86828330
56Thoracic kyphosis (HP:0002942)2.84877852
57Abnormality of nail color (HP:0100643)2.82881142
58Ketoacidosis (HP:0001993)2.81898329
59Cerebral inclusion bodies (HP:0100314)2.81856948
60Hyperbilirubinemia (HP:0002904)2.81059888
61Spastic diplegia (HP:0001264)2.80278568
62Agammaglobulinemia (HP:0004432)2.79121901
63Bronchitis (HP:0012387)2.77230040
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70094621
65Dicarboxylic aciduria (HP:0003215)2.70094621
66Steatorrhea (HP:0002570)2.68285883
67Hypoalphalipoproteinemia (HP:0003233)2.67553904
68Pili torti (HP:0003777)2.67330921
69Spastic paraparesis (HP:0002313)2.66298371
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.64260049
71Global brain atrophy (HP:0002283)2.59520743
72Abnormality of serum amino acid levels (HP:0003112)2.55440840
73Mitral stenosis (HP:0001718)2.54847760
7411 pairs of ribs (HP:0000878)2.52838412
75Thrombocytosis (HP:0001894)2.51374260
76Increased cerebral lipofuscin (HP:0011813)2.48311399
77Hepatocellular carcinoma (HP:0001402)2.48263420
78Axonal loss (HP:0003447)2.47224850
79Abnormality of the corticospinal tract (HP:0002492)2.44762656
80Abnormality of nucleobase metabolism (HP:0010932)2.42391714
81Hypercholesterolemia (HP:0003124)2.40663028
82Ectopia lentis (HP:0001083)2.40520752
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39651180
84Atrophic scars (HP:0001075)2.39137813
85Emphysema (HP:0002097)2.37141007
86Abnormality of the thoracic spine (HP:0100711)2.36795578
87Albinism (HP:0001022)2.36570844
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33035169
89Abnormality of complement system (HP:0005339)2.32618161
90Pancreatic islet-cell hyperplasia (HP:0004510)2.31845853
91Termporal pattern (HP:0011008)2.28405536
92Insidious onset (HP:0003587)2.28405536
93Dysostosis multiplex (HP:0000943)2.26977562
94Vacuolated lymphocytes (HP:0001922)2.26872537
95Cerebral hypomyelination (HP:0006808)2.26454220
96Cholecystitis (HP:0001082)2.26296348
97Abnormal gallbladder physiology (HP:0012438)2.26296348
98Amelogenesis imperfecta (HP:0000705)2.25772166
99Hypochromic microcytic anemia (HP:0004840)2.25084464
100Hypoglycemic seizures (HP:0002173)2.24974810
101Irritability (HP:0000737)2.23327781
102Lethargy (HP:0001254)2.23206208
103Vascular calcification (HP:0004934)2.21977779
104Osteolytic defects of the phalanges of the hand (HP:0009771)2.18400915
105Osteolytic defects of the hand bones (HP:0009699)2.18400915
106Generalized aminoaciduria (HP:0002909)2.18001068
107Abnormal hair laboratory examination (HP:0003328)2.16713676
108Brushfield spots (HP:0001088)2.16472581
109Enlarged epiphyses (HP:0010580)2.14572013
110Metabolic acidosis (HP:0001942)2.13343032
111Increased serum pyruvate (HP:0003542)2.12638392
112Abnormality of glycolysis (HP:0004366)2.12638392
113Abnormal auditory evoked potentials (HP:0006958)2.12090639
114Abnormal gallbladder morphology (HP:0012437)2.09659350
115Hypophosphatemic rickets (HP:0004912)2.08272966
116Cardiovascular calcification (HP:0011915)2.07404321
117Conjugated hyperbilirubinemia (HP:0002908)2.05581156
118Abnormality of purine metabolism (HP:0004352)2.04240308
119Peripheral demyelination (HP:0011096)2.03347031
120Alkalosis (HP:0001948)2.03256013
121Nail dystrophy (HP:0008404)2.02380533
122Epiphyseal stippling (HP:0010655)2.02321957
123Skin nodule (HP:0200036)2.00840022
124Gout (HP:0001997)2.00231110
125Chronic otitis media (HP:0000389)11.0872924
126Generalized amyotrophy (HP:0003700)1.99929412
127Hypoplasia of the fovea (HP:0007750)1.99648879
128Aplasia/Hypoplasia of the fovea (HP:0008060)1.99648879
129Confusion (HP:0001289)1.98953430
130Ankyloglossia (HP:0010296)1.98784126
131Hyperinsulinemic hypoglycemia (HP:0000825)1.98593672
132Cerebral edema (HP:0002181)1.97886827
133Abnormal cartilage morphology (HP:0002763)1.97096854
134Intention tremor (HP:0002080)1.96680963
135Flat acetabular roof (HP:0003180)1.96579413
136Acanthocytosis (HP:0001927)1.95574003
137Congenital stationary night blindness (HP:0007642)1.95017410
138Abnormality of vitamin metabolism (HP:0100508)1.92468942
139Abnormal blistering of the skin (HP:0008066)1.91731307
140Paraparesis (HP:0002385)1.91633566
141Peripheral hypomyelination (HP:0007182)1.91314298
142Malnutrition (HP:0004395)1.90941239
143Increased circulating renin level (HP:0000848)1.90826382
144Cholelithiasis (HP:0001081)1.90334833
145Abnormality of oral frenula (HP:0000190)1.88766466
146Hemorrhage of the eye (HP:0011885)1.88192477
147Megaloblastic anemia (HP:0001889)1.88085740
148Abnormal enzyme/coenzyme activity (HP:0012379)1.87751752
149Abnormality of the alveolar ridges (HP:0006477)1.87699827
150Opisthotonus (HP:0002179)1.86856688
151Back pain (HP:0003418)1.85598029
152Turricephaly (HP:0000262)1.83883888
153White forelock (HP:0002211)1.82863891
154Rickets (HP:0002748)1.80552009
155Abnormality of the pancreatic islet cells (HP:0006476)1.80182744
156Abnormality of endocrine pancreas physiology (HP:0012093)1.80182744
157Vomiting (HP:0002013)1.79758675
158Skin ulcer (HP:0200042)1.79724274
159Glycosuria (HP:0003076)1.79523209
160Ridged nail (HP:0001807)1.78579962
161Missing ribs (HP:0000921)1.78491717
162Impulsivity (HP:0100710)1.78139287
163Abnormality of cells of the erythroid lineage (HP:0012130)1.77387554
164Central scotoma (HP:0000603)1.77170858
165Constricted visual fields (HP:0001133)1.77156659
166Pseudobulbar signs (HP:0002200)1.75472188
167Glomerulosclerosis (HP:0000096)1.74921110
168Focal segmental glomerulosclerosis (HP:0000097)1.74569096
169Mucopolysacchariduria (HP:0008155)1.74192421
170Urinary glycosaminoglycan excretion (HP:0003541)1.74192421
171Alopecia of scalp (HP:0002293)1.72813479
172Patchy hypopigmentation of hair (HP:0011365)1.72669537
173Bony spicule pigmentary retinopathy (HP:0007737)1.72202207
174Premature loss of primary teeth (HP:0006323)1.70426863
175Abnormal number of erythroid precursors (HP:0012131)1.70236054
176Severe visual impairment (HP:0001141)1.68858660
177B lymphocytopenia (HP:0010976)1.67588995
178Increased serum ferritin (HP:0003281)1.67378757
179Personality changes (HP:0000751)1.66164897
180Reduced antithrombin III activity (HP:0001976)1.63423202
181Abnormality of macular pigmentation (HP:0008002)1.63275150
182Abnormality of polysaccharide metabolism (HP:0011012)1.63172035
183Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63172035
184Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63172035
185Natal tooth (HP:0000695)1.62658357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.26358844
2ARAF4.56461113
3EPHB14.40370657
4STK394.25514869
5TLK13.43502746
6MAP3K93.39787523
7OXSR13.35813575
8MET3.16382559
9TESK22.71705878
10MAP3K142.48145246
11WNK42.27373848
12BRAF2.21416561
13SIK12.19875482
14BMPR22.17186487
15MAPKAPK52.10345543
16PIM21.94976874
17NME21.89872116
18PKN21.79090083
19WEE11.63283733
20FGFR21.61706938
21PBK1.56421304
22ERBB41.55284132
23CSNK1G31.52279863
24MAP3K121.48748084
25NTRK11.47120751
26STK161.46614658
27MST1R1.46382257
28INSRR1.42132090
29PKN11.41007979
30SCYL21.38709501
31ILK1.37915465
32CSNK1A1L1.36931958
33RAF11.32892047
34LRRK21.32228824
35CSNK1G11.31359263
36TAOK31.22594991
37ERN11.22491435
38TYRO31.18646088
39CDK121.18532085
40GSK3A1.18210981
41TTK1.16766781
42KSR21.12843055
43ABL21.12153706
44MAPK151.11111754
45PTK61.08454657
46MAP3K81.06916508
47STK38L1.06743330
48CLK11.04696957
49LIMK11.03766090
50FLT31.03082485
51ICK0.99878359
52CSNK1G20.98588927
53LATS10.96013751
54SGK2230.92230238
55SGK4940.92230238
56DDR20.92137432
57IRAK30.91713612
58IRAK20.91149300
59MAP3K60.90028149
60LMTK20.88156080
61TRIB30.87241329
62MAPK110.87068774
63ROCK20.86146873
64UHMK10.86138514
65BUB10.82109672
66BMX0.81330967
67WNK30.81222338
68CSK0.80417843
69FGFR40.78988719
70PAK40.77381321
71BRD40.76055317
72NEK20.73940439
73MAP3K20.72568293
74WNK10.72383540
75RPS6KB20.69824982
76BTK0.68429522
77CDK70.65901850
78ATR0.65857143
79IKBKB0.64933949
80VRK20.64305894
81KIT0.64186295
82MATK0.64138861
83MAP2K20.63592957
84JAK20.61928374
85NEK10.61898570
86GRK60.61687163
87PAK20.61626138
88TRPM70.59496208
89CAMK2B0.58734612
90BRSK20.58294074
91STK100.57227562
92CDC70.56766801
93MAP3K70.55764867
94CAMK2G0.55500994
95CSNK1D0.55426409
96KDR0.55205659
97EIF2AK10.52392758
98DYRK20.51051538
99KSR10.50972432
100MOS0.50421355
101PTK20.49720422
102VRK10.49541513
103CDK190.48687109
104EEF2K0.47498993
105ZAK0.47074136
106IRAK10.45971777
107MAP3K10.45474731
108RET0.44679396
109TGFBR10.44343369
110CAMK2D0.43934963
111AURKB0.42707534
112CSF1R0.42019607
113FES0.41060620
114PAK30.40301826
115PASK0.39593649
116MAP3K110.39387106
117PDPK10.39233349
118TESK10.38066416
119PRKCQ0.37913249
120MAP3K130.37582293
121PINK10.37449881
122CHUK0.36759259
123MAPK40.36475222
124SRPK10.36474983
125PRKD30.36428002
126MAPKAPK30.36307727
127ERBB20.36263655
128DAPK10.35566213
129PAK10.35246640
130PRKD10.35048888
131CDK60.33840084
132EPHA40.33693498
133PRPF4B0.33535030
134STK40.33248934
135MTOR0.33181468
136PRKACB0.32963449
137CHEK10.32223678
138EPHA20.32007380
139CDK40.31348803
140NEK90.29682804
141STK30.29570602
142PLK10.29204452
143CHEK20.28112624
144SMG10.27897734
145AURKA0.26590072
146DAPK30.25890046
147MAP2K60.25497775
148MAP2K30.24545131
149CSNK2A10.24534085
150ZAP700.23272825
151MAP2K10.23130847
152RPS6KA40.22668768
153EIF2AK30.22630495
154IGF1R0.22590026
155MAP3K50.21797552
156ATM0.20509945
157TYK20.19065670
158AKT20.18588407
159CSNK2A20.18540301

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.76687169
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.35652207
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.27277173
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.93901725
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88520285
6Fatty acid elongation_Homo sapiens_hsa000622.52920569
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52613540
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40909536
9Fatty acid degradation_Homo sapiens_hsa000712.33006064
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29992836
11Steroid biosynthesis_Homo sapiens_hsa001002.25390910
12Arginine biosynthesis_Homo sapiens_hsa002202.24517056
13Butanoate metabolism_Homo sapiens_hsa006502.24507543
14Histidine metabolism_Homo sapiens_hsa003402.11952379
15Tryptophan metabolism_Homo sapiens_hsa003802.10264896
16Peroxisome_Homo sapiens_hsa041462.07507418
17Ribosome_Homo sapiens_hsa030102.07413635
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06803154
19Propanoate metabolism_Homo sapiens_hsa006402.02099315
20Fatty acid metabolism_Homo sapiens_hsa012122.00416847
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98340105
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92601481
23Sulfur metabolism_Homo sapiens_hsa009201.90986596
24Complement and coagulation cascades_Homo sapiens_hsa046101.85162355
25Folate biosynthesis_Homo sapiens_hsa007901.82614760
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78589966
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75083940
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70306114
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65999942
30Base excision repair_Homo sapiens_hsa034101.65893596
31Chemical carcinogenesis_Homo sapiens_hsa052041.64529651
32Selenocompound metabolism_Homo sapiens_hsa004501.63062749
33Homologous recombination_Homo sapiens_hsa034401.58738543
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.58561812
35Vitamin B6 metabolism_Homo sapiens_hsa007501.54913864
36beta-Alanine metabolism_Homo sapiens_hsa004101.51334186
37PPAR signaling pathway_Homo sapiens_hsa033201.50193966
38Biosynthesis of amino acids_Homo sapiens_hsa012301.46232808
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35713172
40Glutathione metabolism_Homo sapiens_hsa004801.35287507
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.34898735
42Arginine and proline metabolism_Homo sapiens_hsa003301.34204774
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.31740509
44Pyruvate metabolism_Homo sapiens_hsa006201.30933408
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30135471
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30106547
47Retinol metabolism_Homo sapiens_hsa008301.29706325
48Bile secretion_Homo sapiens_hsa049761.29270251
49Bladder cancer_Homo sapiens_hsa052191.27671678
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26680878
51Carbon metabolism_Homo sapiens_hsa012001.23969357
52Pyrimidine metabolism_Homo sapiens_hsa002401.21196374
53Pancreatic cancer_Homo sapiens_hsa052121.18862349
54Tyrosine metabolism_Homo sapiens_hsa003501.17523039
55Thyroid cancer_Homo sapiens_hsa052161.15930833
56Starch and sucrose metabolism_Homo sapiens_hsa005001.15668574
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.15148361
58One carbon pool by folate_Homo sapiens_hsa006701.14377062
59Small cell lung cancer_Homo sapiens_hsa052221.06796309
60ABC transporters_Homo sapiens_hsa020101.06248081
61Chronic myeloid leukemia_Homo sapiens_hsa052201.06171674
62Vitamin digestion and absorption_Homo sapiens_hsa049771.03530692
63Pentose phosphate pathway_Homo sapiens_hsa000301.02548238
64p53 signaling pathway_Homo sapiens_hsa041151.01791943
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96304786
66Caffeine metabolism_Homo sapiens_hsa002320.95927447
67Phenylalanine metabolism_Homo sapiens_hsa003600.93265999
68Sulfur relay system_Homo sapiens_hsa041220.91569277
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91168063
70Acute myeloid leukemia_Homo sapiens_hsa052210.87038712
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.86896967
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85515827
73Fat digestion and absorption_Homo sapiens_hsa049750.82218424
74Staphylococcus aureus infection_Homo sapiens_hsa051500.79964924
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77680481
76Lysine degradation_Homo sapiens_hsa003100.77079308
77Ether lipid metabolism_Homo sapiens_hsa005650.73068880
78Antigen processing and presentation_Homo sapiens_hsa046120.72506083
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68994062
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68856727
81Fatty acid biosynthesis_Homo sapiens_hsa000610.65809265
82Metabolic pathways_Homo sapiens_hsa011000.65653755
83Fanconi anemia pathway_Homo sapiens_hsa034600.65123005
84Spliceosome_Homo sapiens_hsa030400.64974946
85Hepatitis C_Homo sapiens_hsa051600.62823241
86Non-homologous end-joining_Homo sapiens_hsa034500.60683413
87Linoleic acid metabolism_Homo sapiens_hsa005910.60525625
88Inositol phosphate metabolism_Homo sapiens_hsa005620.59806114
89Apoptosis_Homo sapiens_hsa042100.59461587
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59122886
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.56267893
92Protein export_Homo sapiens_hsa030600.53877699
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50184299
94Glycerolipid metabolism_Homo sapiens_hsa005610.47587645
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44268496
96Non-small cell lung cancer_Homo sapiens_hsa052230.42590572
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41534446
98DNA replication_Homo sapiens_hsa030300.40904777
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.36841617
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34748021
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.32862072
102Other glycan degradation_Homo sapiens_hsa005110.27157364
103Lysosome_Homo sapiens_hsa041420.26817133
104Prion diseases_Homo sapiens_hsa050200.23392981
105Renin-angiotensin system_Homo sapiens_hsa046140.22702118
106Fructose and mannose metabolism_Homo sapiens_hsa000510.21841635
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21388223
108Sphingolipid metabolism_Homo sapiens_hsa006000.19802500
109Mismatch repair_Homo sapiens_hsa034300.19284540
110Arachidonic acid metabolism_Homo sapiens_hsa005900.18941192
111Galactose metabolism_Homo sapiens_hsa000520.18711489
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18672385
113N-Glycan biosynthesis_Homo sapiens_hsa005100.16557103
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.16473242
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.07263353
116Ovarian steroidogenesis_Homo sapiens_hsa049130.06285632
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.03268413
118ECM-receptor interaction_Homo sapiens_hsa045120.02641120
119Thyroid hormone synthesis_Homo sapiens_hsa049180.02132148
120Nucleotide excision repair_Homo sapiens_hsa03420-0.0575384
121Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0572573
122Insulin resistance_Homo sapiens_hsa04931-0.0529942
123AMPK signaling pathway_Homo sapiens_hsa04152-0.0450772
124Protein digestion and absorption_Homo sapiens_hsa04974-0.0438046
125Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0401043
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0182865

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