TM9SF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.43197637
2COPI coating of Golgi vesicle (GO:0048205)4.43197637
3L-phenylalanine catabolic process (GO:0006559)4.37679363
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.37679363
5protein maturation by protein folding (GO:0022417)4.36422174
6L-phenylalanine metabolic process (GO:0006558)4.32242353
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.32242353
8aromatic amino acid family catabolic process (GO:0009074)4.08649958
9skin morphogenesis (GO:0043589)3.87488751
10indole-containing compound catabolic process (GO:0042436)3.86994512
11indolalkylamine catabolic process (GO:0046218)3.86994512
12tryptophan catabolic process (GO:0006569)3.86994512
13sulfur amino acid catabolic process (GO:0000098)3.85423472
14protein carboxylation (GO:0018214)3.81233104
15peptidyl-glutamic acid carboxylation (GO:0017187)3.81233104
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.79994615
17cell adhesion mediated by integrin (GO:0033627)3.77685436
18cysteine metabolic process (GO:0006534)3.76051640
19tryptophan metabolic process (GO:0006568)3.71557634
20alpha-linolenic acid metabolic process (GO:0036109)3.63912728
21protein retention in ER lumen (GO:0006621)3.61620296
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.60225227
23glyoxylate metabolic process (GO:0046487)3.59772484
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58969513
25kynurenine metabolic process (GO:0070189)3.58020443
26negative regulation of fibrinolysis (GO:0051918)3.44206655
27peptidyl-proline hydroxylation (GO:0019511)3.41227403
28lysine metabolic process (GO:0006553)3.41178591
29lysine catabolic process (GO:0006554)3.41178591
30desmosome organization (GO:0002934)3.40581674
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.36862417
32hemidesmosome assembly (GO:0031581)3.36458616
33homocysteine metabolic process (GO:0050667)3.34606213
34bile acid biosynthetic process (GO:0006699)3.33995835
35type B pancreatic cell proliferation (GO:0044342)3.32708740
36intestinal cholesterol absorption (GO:0030299)3.32063011
37valine metabolic process (GO:0006573)3.30798563
38axonemal dynein complex assembly (GO:0070286)3.29876289
39regulation of fibrinolysis (GO:0051917)3.27737291
40amino-acid betaine metabolic process (GO:0006577)3.27179009
41signal peptide processing (GO:0006465)3.20661783
42drug transmembrane transport (GO:0006855)3.20593898
43regulation of protein activation cascade (GO:2000257)3.17266510
44complement activation, alternative pathway (GO:0006957)3.16585039
45proline biosynthetic process (GO:0006561)3.16399558
46lipopolysaccharide biosynthetic process (GO:0009103)3.16153807
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13761105
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13761105
49amyloid precursor protein catabolic process (GO:0042987)3.11280378
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.10136607
51high-density lipoprotein particle remodeling (GO:0034375)3.08490848
52protein hydroxylation (GO:0018126)3.07717293
534-hydroxyproline metabolic process (GO:0019471)3.06533816
54basement membrane organization (GO:0071711)3.05905216
55regulation of complement activation (GO:0030449)3.02889856
56GDP-mannose metabolic process (GO:0019673)3.00372152
57drug transport (GO:0015893)2.99123994
58regulation of cholesterol homeostasis (GO:2000188)2.95416689
59cellular modified amino acid catabolic process (GO:0042219)2.91900541
60aromatic amino acid family metabolic process (GO:0009072)2.91869099
61regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91634375
62reverse cholesterol transport (GO:0043691)2.91198487
63bile acid metabolic process (GO:0008206)2.89581375
64keratan sulfate catabolic process (GO:0042340)2.88819613
65COPII vesicle coating (GO:0048208)2.87798588
66ethanol oxidation (GO:0006069)2.87410305
67proline metabolic process (GO:0006560)2.85184346
68urate metabolic process (GO:0046415)2.84016778
69urea metabolic process (GO:0019627)2.80723352
70urea cycle (GO:0000050)2.80723352
71regulation of triglyceride catabolic process (GO:0010896)2.79305817
72negative regulation of protein activation cascade (GO:2000258)2.78720236
73zinc ion transmembrane transport (GO:0071577)2.78579987
74bile acid and bile salt transport (GO:0015721)2.77593441
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76175206
76regulation of plasminogen activation (GO:0010755)2.75295761
77phospholipid efflux (GO:0033700)2.74696067
78carnitine metabolic process (GO:0009437)2.74592017
79indolalkylamine metabolic process (GO:0006586)2.74269630
80serine family amino acid catabolic process (GO:0009071)2.73945532
81fatty acid beta-oxidation (GO:0006635)2.73849109
82negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73845429
83fibrinolysis (GO:0042730)2.73806938
84nitrogen cycle metabolic process (GO:0071941)2.71687300
85negative regulation of cholesterol transport (GO:0032375)2.71525877
86negative regulation of sterol transport (GO:0032372)2.71525877
87peptide catabolic process (GO:0043171)2.70942922
88antigen processing and presentation of endogenous antigen (GO:0019883)2.70926467
89fatty acid oxidation (GO:0019395)2.70800298
90negative regulation of complement activation (GO:0045916)2.69936589
91cellular biogenic amine catabolic process (GO:0042402)2.69324788
92amine catabolic process (GO:0009310)2.69324788
93acylglycerol homeostasis (GO:0055090)2.69275802
94triglyceride homeostasis (GO:0070328)2.69275802
95serine family amino acid biosynthetic process (GO:0009070)2.69173586
96regulation of metalloenzyme activity (GO:0048552)2.68279683
97cellular glucuronidation (GO:0052695)2.67587245
98nucleotide-sugar biosynthetic process (GO:0009226)2.66035075
99response to nitrosative stress (GO:0051409)2.65881895
100exocrine pancreas development (GO:0031017)2.65540396
101membrane protein ectodomain proteolysis (GO:0006509)2.65221082
102plasma lipoprotein particle clearance (GO:0034381)2.64450356
103plasma lipoprotein particle assembly (GO:0034377)2.63986638
104lipid oxidation (GO:0034440)2.63490975
105lipoprotein metabolic process (GO:0042157)2.63245548
106cellular copper ion homeostasis (GO:0006878)2.62129709
107protein-lipid complex remodeling (GO:0034368)2.61731754
108macromolecular complex remodeling (GO:0034367)2.61731754
109plasma lipoprotein particle remodeling (GO:0034369)2.61731754
110benzene-containing compound metabolic process (GO:0042537)2.61119655
111positive regulation of nuclease activity (GO:0032075)2.61030207
112endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.60800368
113L-serine transport (GO:0015825)2.60718637
114extracellular fibril organization (GO:0043206)2.60691164
115positive regulation of lipoprotein lipase activity (GO:0051006)2.60397583
116positive regulation of triglyceride lipase activity (GO:0061365)2.60397583
117hyaluronan catabolic process (GO:0030214)2.59385581
118polyketide metabolic process (GO:0030638)2.58037016
119doxorubicin metabolic process (GO:0044598)2.58037016
120daunorubicin metabolic process (GO:0044597)2.58037016
121glucuronate metabolic process (GO:0019585)2.57142339
122uronic acid metabolic process (GO:0006063)2.57142339
123tricarboxylic acid metabolic process (GO:0072350)2.56970898
124serine family amino acid metabolic process (GO:0009069)2.56929247
125positive regulation of triglyceride metabolic process (GO:0090208)2.56357572
126glycine metabolic process (GO:0006544)2.54616791
127aldehyde catabolic process (GO:0046185)2.54509350
128alpha-amino acid catabolic process (GO:1901606)2.53892991
129mannosylation (GO:0097502)2.53600229
130positive regulation of fatty acid biosynthetic process (GO:0045723)2.53565049
131regulation of cholesterol esterification (GO:0010872)2.53458469
132protein-lipid complex assembly (GO:0065005)2.52461148
133opsonization (GO:0008228)2.52339740
134endoplasmic reticulum unfolded protein response (GO:0030968)2.51092948
135apoptotic cell clearance (GO:0043277)2.49688402
136UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49409196
137regulation of cholesterol metabolic process (GO:0090181)2.49388630
138regulation of cholesterol biosynthetic process (GO:0045540)2.48319857
139branched-chain amino acid metabolic process (GO:0009081)2.47900352
140primary alcohol catabolic process (GO:0034310)2.47822412
141membrane protein intracellular domain proteolysis (GO:0031293)2.46972759
142sequestering of metal ion (GO:0051238)2.46692236
143glutamine family amino acid biosynthetic process (GO:0009084)2.46181636
144cellular response to unfolded protein (GO:0034620)2.45313449
145protein N-linked glycosylation via asparagine (GO:0018279)2.39408896
146negative regulation of chondrocyte differentiation (GO:0032331)2.39032604
147muscle cell migration (GO:0014812)2.38924337
148regulation of integrin-mediated signaling pathway (GO:2001044)2.38717253
149vesicle coating (GO:0006901)2.38438092
150membrane budding (GO:0006900)2.37881508
151peptidyl-asparagine modification (GO:0018196)2.37549987
152protein N-linked glycosylation (GO:0006487)2.36849476
153dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.36452933
154zinc ion transport (GO:0006829)2.36381229
155positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.35622064
156dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.34863871
157lipopolysaccharide metabolic process (GO:0008653)2.34456912
158aminoglycoside antibiotic metabolic process (GO:0030647)2.34117056
159negative regulation of humoral immune response (GO:0002921)2.31916129
160glucose catabolic process (GO:0006007)2.30966868
161galactose catabolic process (GO:0019388)2.30649464
162cellular response to topologically incorrect protein (GO:0035967)2.30123036
163cellular zinc ion homeostasis (GO:0006882)2.28232316
164G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.25732730
165very-low-density lipoprotein particle assembly (GO:0034379)2.25022083
166C-terminal protein lipidation (GO:0006501)2.24513233
167positive regulation of cellular amine metabolic process (GO:0033240)2.24441648
168ER-nucleus signaling pathway (GO:0006984)2.24263078
169negative regulation of coagulation (GO:0050819)2.23495646
170barbed-end actin filament capping (GO:0051016)2.23145206
171gap junction assembly (GO:0016264)2.22718840
172regulation of nuclease activity (GO:0032069)2.22286024
173galactose metabolic process (GO:0006012)2.22154249
174endodermal cell differentiation (GO:0035987)2.21329002
175nuclear envelope reassembly (GO:0031468)2.20336549
176mitotic nuclear envelope reassembly (GO:0007084)2.20336549
177motile cilium assembly (GO:0044458)2.17523418
178wound healing, spreading of epidermal cells (GO:0035313)2.17323889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.89276347
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.88422423
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.57587218
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.44281147
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.77829158
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.76840371
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.50000849
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.20462909
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.17626786
10ZNF263_19887448_ChIP-Seq_K562_Human3.07531638
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.78644910
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.77294341
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44733481
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.37949530
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.35186622
16CLOCK_20551151_ChIP-Seq_293T_Human2.33622629
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32495548
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32327509
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20125378
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18733779
21GATA1_22025678_ChIP-Seq_K562_Human2.14735880
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09703860
23ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.00659483
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.97244049
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92011058
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84543309
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78914328
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77721283
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77301829
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73957673
31* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71700303
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.64708722
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62204393
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62059670
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58487684
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58347333
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54946612
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54923058
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53315397
40GABP_19822575_ChIP-Seq_HepG2_Human1.51420013
41GATA4_25053715_ChIP-Seq_YYC3_Human1.48768717
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47754896
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47690390
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47024330
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46799912
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46118149
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45864258
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.45374562
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44606527
50* TP53_22127205_ChIP-Seq_IMR90_Human1.43744368
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42999127
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42103785
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41793238
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37097999
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.36931454
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34475641
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32921104
58* DCP1A_22483619_ChIP-Seq_HELA_Human1.32788449
59* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31294498
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30461497
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26380682
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25395424
63SCL_19346495_ChIP-Seq_HPC-7_Human1.25123315
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.24919674
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24556435
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23686679
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23437599
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23028923
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19840518
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.19626624
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.19481016
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18914649
73SOX2_20726797_ChIP-Seq_SW620_Human1.18252429
74* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17516731
75* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17232772
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15224533
77VDR_21846776_ChIP-Seq_THP-1_Human1.14630723
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.14621631
79LXR_22292898_ChIP-Seq_THP-1_Human1.14129830
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.13960366
81MAF_26560356_Chip-Seq_TH1_Human1.12963761
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12858418
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12118412
84MYB_26560356_Chip-Seq_TH2_Human1.11339239
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11277058
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10521165
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.10489451
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10360505
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09656172
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09652416
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09283333
92* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09227727
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08950640
94* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08797039
95CJUN_26792858_Chip-Seq_BT549_Human1.08748928
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08505688
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07446393
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.07273572
99RACK7_27058665_Chip-Seq_MCF-7_Human1.07247965
100TFEB_21752829_ChIP-Seq_HELA_Human1.06975595
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06169411
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05790364
103GATA6_25053715_ChIP-Seq_YYC3_Human1.05733395
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05555954
105EOMES_21245162_ChIP-Seq_HESCs_Human1.04014010
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03385914
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03270859
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02984186
109MYC_22102868_ChIP-Seq_BL_Human1.02777593
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02154399
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02093191
112MYB_26560356_Chip-Seq_TH1_Human1.01911090
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01534076
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01437749
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00995132
116UTX_26944678_Chip-Seq_JUKART_Human1.00443934
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00437460
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00374544
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99410788
120* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99348604
121CSB_26484114_Chip-Seq_FIBROBLAST_Human0.99322682
122VDR_24763502_ChIP-Seq_THP-1_Human0.98613842
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97248561
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97219925
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97176334
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97173181
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97026056
128SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96994385
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.96993991
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.96781965
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96475037
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96430016
133* SPI1_23547873_ChIP-Seq_NB4_Human0.96404596
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96261417
135BRD4_25478319_ChIP-Seq_HGPS_Human0.96105661
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95774715
137RARB_24833708_ChIP-Seq_LIVER_Mouse0.95420961
138* GABP_17652178_ChIP-ChIP_JURKAT_Human0.94981107
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93336869
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93155211
141* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92304880
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92049049
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.90386186
144* RUNX1_22412390_ChIP-Seq_EML_Mouse0.90254059
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89255034
146SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89165514
147SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89165514
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89004682
149AR_21909140_ChIP-Seq_LNCAP_Human0.88688018
150ATF3_27146783_Chip-Seq_COLON_Human0.87882155
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87360719
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86117933
153SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85746285
154RUNX_20019798_ChIP-Seq_JUKART_Human0.85638460
155CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85400117
156ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84888183
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84507160
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84291894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.57936556
2MP0005360_urolithiasis4.07507620
3MP0005365_abnormal_bile_salt3.57809056
4MP0005257_abnormal_intraocular_pressure3.55762304
5MP0005085_abnormal_gallbladder_physiolo3.40381073
6MP0008438_abnormal_cutaneous_collagen2.98960254
7MP0003252_abnormal_bile_duct2.76781521
8MP0009780_abnormal_chondrocyte_physiolo2.51761790
9MP0008875_abnormal_xenobiotic_pharmacok2.48680434
10MP0009840_abnormal_foam_cell2.46874904
11MP0005083_abnormal_biliary_tract2.35441105
12MP0001666_abnormal_nutrient_absorption2.22501655
13MP0003195_calcinosis2.14283923
14MP0006054_spinal_hemorrhage2.13862696
15MP0003806_abnormal_nucleotide_metabolis2.13151502
16MP0003705_abnormal_hypodermis_morpholog2.02898939
17MP0010030_abnormal_orbit_morphology1.95329401
18MP0003300_gastrointestinal_ulcer1.91136662
19MP0010329_abnormal_lipoprotein_level1.88501829
20MP0001849_ear_inflammation1.83108406
21MP0005408_hypopigmentation1.82427382
22MP0003191_abnormal_cellular_cholesterol1.79217473
23MP0005623_abnormal_meninges_morphology1.78348149
24MP0002138_abnormal_hepatobiliary_system1.77960348
25MP0008260_abnormal_autophagy1.76093850
26MP0003724_increased_susceptibility_to1.71748888
27MP0005332_abnormal_amino_acid1.70640664
28MP0009643_abnormal_urine_homeostasis1.69515607
29MP0005275_abnormal_skin_tensile1.65027666
30MP0003950_abnormal_plasma_membrane1.64415461
31MP0004019_abnormal_vitamin_homeostasis1.64335488
32MP0000516_abnormal_urinary_system1.59225266
33MP0005367_renal/urinary_system_phenotyp1.59225266
34MP0001542_abnormal_bone_strength1.55540319
35MP0004233_abnormal_muscle_weight1.55468455
36MP0005220_abnormal_exocrine_pancreas1.54740133
37MP0000609_abnormal_liver_physiology1.52255776
38MP0000013_abnormal_adipose_tissue1.47477359
39MP0004858_abnormal_nervous_system1.47361367
40MP0005058_abnormal_lysosome_morphology1.47232582
41MP0003279_aneurysm1.44184491
42MP0001958_emphysema1.41795946
43MP0001661_extended_life_span1.35623732
44MP0003436_decreased_susceptibility_to1.35210017
45MP0009053_abnormal_anal_canal1.33075140
46MP0003941_abnormal_skin_development1.32890586
47MP0005508_abnormal_skeleton_morphology1.31723072
48MP0003186_abnormal_redox_activity1.29446019
49MP0005164_abnormal_response_to1.27167367
50MP0005171_absent_coat_pigmentation1.25867676
51MP0005319_abnormal_enzyme/_coenzyme1.25198153
52MP0000467_abnormal_esophagus_morphology1.25016103
53MP0009384_cardiac_valve_regurgitation1.23871098
54MP0002060_abnormal_skin_morphology1.21764678
55MP0002282_abnormal_trachea_morphology1.21261365
56MP0000534_abnormal_ureter_morphology1.20911594
57MP0003942_abnormal_urinary_system1.18819090
58MP0003656_abnormal_erythrocyte_physiolo1.18187324
59MP0005503_abnormal_tendon_morphology1.18126228
60MP0002118_abnormal_lipid_homeostasis1.18008118
61MP0004272_abnormal_basement_membrane1.17351020
62MP0003566_abnormal_cell_adhesion1.17222582
63MP0005197_abnormal_uvea_morphology1.17193678
64MP0010234_abnormal_vibrissa_follicle1.15941806
65MP0000538_abnormal_urinary_bladder1.14498124
66MP0001835_abnormal_antigen_presentation1.08567072
67MP0000762_abnormal_tongue_morphology1.07337960
68MP0008469_abnormal_protein_level1.07262116
69MP0002933_joint_inflammation1.04922789
70MP0005023_abnormal_wound_healing1.04795646
71MP0005636_abnormal_mineral_homeostasis1.04362407
72MP0001533_abnormal_skeleton_physiology1.04291345
73MP0000598_abnormal_liver_morphology1.04267565
74MP0005084_abnormal_gallbladder_morpholo1.03887900
75MP0010368_abnormal_lymphatic_system1.02681305
76MP0002928_abnormal_bile_duct1.02351672
77MP0001243_abnormal_dermal_layer1.02205448
78MP0002909_abnormal_adrenal_gland1.02097671
79MP0005165_increased_susceptibility_to1.00556990
80MP0003868_abnormal_feces_composition0.99695183
81MP0009764_decreased_sensitivity_to0.99584520
82MP0005464_abnormal_platelet_physiology0.98665939
83MP0002136_abnormal_kidney_physiology0.98085732
84MP0000751_myopathy0.97868336
85MP0000003_abnormal_adipose_tissue0.96689395
86MP0001873_stomach_inflammation0.95215157
87MP0010155_abnormal_intestine_physiology0.95092700
88MP0002419_abnormal_innate_immunity0.94707829
89MP0000465_gastrointestinal_hemorrhage0.94452846
90MP0000358_abnormal_cell_content/0.94346673
91MP0002132_abnormal_respiratory_system0.93590277
92MP0002166_altered_tumor_susceptibility0.93201855
93MP0001845_abnormal_inflammatory_respons0.92759245
94MP0003011_delayed_dark_adaptation0.92571087
95MP0000685_abnormal_immune_system0.89757945
96MP0001764_abnormal_homeostasis0.88505981
97MP0009763_increased_sensitivity_to0.88236980
98MP0001915_intracranial_hemorrhage0.88046438
99MP0009785_altered_susceptibility_to0.87657643
100MP0004264_abnormal_extraembryonic_tissu0.87279072
101MP0004947_skin_inflammation0.87169846
102MP0002089_abnormal_postnatal_growth/wei0.87143168
103MP0000678_abnormal_parathyroid_gland0.86926962
104MP0005025_abnormal_response_to0.86104072
105MP0001944_abnormal_pancreas_morphology0.86056202
106MP0001756_abnormal_urination0.85273728
107MP0005501_abnormal_skin_physiology0.84914284
108MP0003385_abnormal_body_wall0.84077849
109MP0000858_altered_metastatic_potential0.83309435
110MP0005584_abnormal_enzyme/coenzyme_acti0.83166317
111MP0010771_integument_phenotype0.82824531
112MP0001216_abnormal_epidermal_layer0.82256469
113MP0005670_abnormal_white_adipose0.81982908
114MP0002396_abnormal_hematopoietic_system0.81939374
115MP0000579_abnormal_nail_morphology0.80854116
116MP0001790_abnormal_immune_system0.80325415
117MP0005387_immune_system_phenotype0.80325415
118MP0002254_reproductive_system_inflammat0.79953498
119MP0009333_abnormal_splenocyte_physiolog0.79394551
120MP0010352_gastrointestinal_tract_polyps0.78356178
121MP0003091_abnormal_cell_migration0.77058321
122MP0003303_peritoneal_inflammation0.76721908
123MP0000163_abnormal_cartilage_morphology0.76655267
124MP0000767_abnormal_smooth_muscle0.76497197
125MP0001270_distended_abdomen0.76064156
126MP0002938_white_spotting0.75470519
127MP0002896_abnormal_bone_mineralization0.75020926
128MP0005193_abnormal_anterior_eye0.74807594
129MP0002877_abnormal_melanocyte_morpholog0.74780339
130MP0009697_abnormal_copulation0.74300608
131MP0002693_abnormal_pancreas_physiology0.73130192
132MP0005595_abnormal_vascular_smooth0.72923122
133MP0009642_abnormal_blood_homeostasis0.72683241
134MP0000613_abnormal_salivary_gland0.71753914
135MP0003172_abnormal_lysosome_physiology0.71602989
136MP0005395_other_phenotype0.70814427
137MP0000371_diluted_coat_color0.70588649
138MP0005330_cardiomyopathy0.69823044
139MP0002168_other_aberrant_phenotype0.69714628
140MP0003453_abnormal_keratinocyte_physiol0.69701336
141MP0003795_abnormal_bone_structure0.69513546
142MP0000249_abnormal_blood_vessel0.69232862
143MP0002098_abnormal_vibrissa_morphology0.68800772
144MP0004883_abnormal_blood_vessel0.68732509
145MP0005410_abnormal_fertilization0.67986277
146MP0001853_heart_inflammation0.67298133
147MP0005451_abnormal_body_composition0.67265102
148MP0002135_abnormal_kidney_morphology0.66589953
149MP0005390_skeleton_phenotype0.66266717
150MP0004043_abnormal_pH_regulation0.65860321
151MP0002998_abnormal_bone_remodeling0.65409748
152MP0005000_abnormal_immune_tolerance0.64925057
153MP0002653_abnormal_ependyma_morphology0.64704519
154MP0004782_abnormal_surfactant_physiolog0.64630342
155MP0002452_abnormal_antigen_presenting0.64568666
156MP0002405_respiratory_system_inflammati0.62715146
157MP0002295_abnormal_pulmonary_circulatio0.62703615
158MP0001800_abnormal_humoral_immune0.60118880

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.26761751
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.22239302
3Intrahepatic cholestasis (HP:0001406)4.14976534
4Deep venous thrombosis (HP:0002625)4.05925618
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.87639140
6Xanthomatosis (HP:0000991)3.84804600
7Prolonged partial thromboplastin time (HP:0003645)3.45623525
8Abnormality of the intrinsic pathway (HP:0010989)3.37821333
9Short nail (HP:0001799)3.35191028
10Abnormality of the common coagulation pathway (HP:0010990)3.27974484
11Premature rupture of membranes (HP:0001788)3.18216700
12Abnormality of dentin (HP:0010299)3.14204744
13Generalized aminoaciduria (HP:0002909)3.04662288
14Vacuolated lymphocytes (HP:0001922)3.02736281
15Ketosis (HP:0001946)3.01631834
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.01135324
17Protrusio acetabuli (HP:0003179)2.99846929
18Nonimmune hydrops fetalis (HP:0001790)2.99468599
19Hypobetalipoproteinemia (HP:0003563)2.96936406
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94468357
21Complement deficiency (HP:0004431)2.92900015
22Joint hemorrhage (HP:0005261)2.86691060
23Follicular hyperkeratosis (HP:0007502)2.86636889
24Fat malabsorption (HP:0002630)2.85408087
25Ketoacidosis (HP:0001993)2.84740453
26Hypoglycemic seizures (HP:0002173)2.84602105
27Abnormality of the distal phalanges of the toes (HP:0010182)2.84140881
28Conjugated hyperbilirubinemia (HP:0002908)2.83966538
29Abnormality of fatty-acid metabolism (HP:0004359)2.72000677
30Myocardial infarction (HP:0001658)2.64631560
31Vascular tortuosity (HP:0004948)2.64066272
32Hyperinsulinemic hypoglycemia (HP:0000825)2.62336305
33Abnormality of glycolipid metabolism (HP:0010969)2.61883977
34Abnormality of liposaccharide metabolism (HP:0010968)2.61883977
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.61883977
36Hypolipoproteinemia (HP:0010981)2.59249802
37Hypoalphalipoproteinemia (HP:0003233)2.54061397
38Urinary glycosaminoglycan excretion (HP:0003541)2.53591302
39Mucopolysacchariduria (HP:0008155)2.53591302
40Hyperammonemia (HP:0001987)2.53142323
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.53089099
42Cardiovascular calcification (HP:0011915)2.52220073
43Glucose intolerance (HP:0000833)2.52110402
44Abnormality of purine metabolism (HP:0004352)2.51358644
45Hyperlipoproteinemia (HP:0010980)2.49712034
46Abnormality of carpal bone ossification (HP:0006257)2.48609353
47Abnormality of the umbilical cord (HP:0010881)2.46780112
48Abnormality of complement system (HP:0005339)2.46677353
49Arterial tortuosity (HP:0005116)2.46658677
50Abnormality of nucleobase metabolism (HP:0010932)2.45726117
51Hyperglycinuria (HP:0003108)2.42567635
52Vascular calcification (HP:0004934)2.42317321
53Hand muscle atrophy (HP:0009130)2.41844203
54Hyperbilirubinemia (HP:0002904)2.40644139
55Abnormality of the acetabulum (HP:0003170)2.40109250
56Upper limb amyotrophy (HP:0009129)2.39870069
57Distal upper limb amyotrophy (HP:0007149)2.39870069
58Natal tooth (HP:0000695)2.37976796
59Type I transferrin isoform profile (HP:0003642)2.36463337
60Cervical subluxation (HP:0003308)2.35377030
61Abnormality of pyrimidine metabolism (HP:0004353)2.34461064
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32297569
63Abnormality of polysaccharide metabolism (HP:0011012)2.32297569
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32297569
65Late onset (HP:0003584)2.31538318
66Peritonitis (HP:0002586)2.31420889
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29653666
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28415710
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25528867
70Abnormal respiratory motile cilium physiology (HP:0012261)2.23963821
71Abnormal respiratory motile cilium morphology (HP:0005938)2.23167865
72Abnormal respiratory epithelium morphology (HP:0012253)2.23167865
73Epidermoid cyst (HP:0200040)2.21885691
74Abnormal protein glycosylation (HP:0012346)2.21229733
75Abnormal glycosylation (HP:0012345)2.21229733
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21229733
77Abnormal protein N-linked glycosylation (HP:0012347)2.21229733
78Systemic lupus erythematosus (HP:0002725)2.21011951
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20004136
80Steatorrhea (HP:0002570)2.19611158
81Mitral stenosis (HP:0001718)2.19265126
82Dicarboxylic aciduria (HP:0003215)2.18490457
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18490457
84Ectopia lentis (HP:0001083)2.16095272
85Symptomatic seizures (HP:0011145)2.15222110
86Hepatocellular carcinoma (HP:0001402)2.14798029
87Atelectasis (HP:0100750)2.14624087
88Glomerulonephritis (HP:0000099)2.14616395
89Abnormality of serine family amino acid metabolism (HP:0010894)2.14499971
90Abnormality of glycine metabolism (HP:0010895)2.14499971
91Dysostosis multiplex (HP:0000943)2.13463156
92Esophageal varix (HP:0002040)2.13405846
93Abnormality of proline metabolism (HP:0010907)2.13017281
94Hydroxyprolinuria (HP:0003080)2.13017281
95Occipital encephalocele (HP:0002085)2.12814976
96Abnormal gallbladder physiology (HP:0012438)2.12770754
97Cholecystitis (HP:0001082)2.12770754
98Elbow flexion contracture (HP:0002987)2.10633791
99Rhinitis (HP:0012384)2.10591749
100Hypokinesia (HP:0002375)2.10340650
101Abnormal ciliary motility (HP:0012262)2.10289731
102Gout (HP:0001997)2.10007008
103Abnormal delivery (HP:0001787)2.08605216
104Recurrent gram-negative bacterial infections (HP:0005420)2.08496958
105Fragile skin (HP:0001030)2.08219333
106Wormian bones (HP:0002645)2.06031610
107Abnormal enzyme/coenzyme activity (HP:0012379)2.04717426
108Proximal tubulopathy (HP:0000114)2.03473202
109Abnormal umbilical cord blood vessels (HP:0011403)2.02163154
110Single umbilical artery (HP:0001195)2.02163154
111Abnormality of the fetal cardiovascular system (HP:0010948)2.02163154
112Abnormality of the Achilles tendon (HP:0005109)1.99271904
113Bladder diverticulum (HP:0000015)1.98822004
114Atrophic scars (HP:0001075)1.98508409
115Vertebral compression fractures (HP:0002953)1.98362758
116Elevated alkaline phosphatase (HP:0003155)1.97570511
117Aortic dissection (HP:0002647)1.96470614
118Opisthotonus (HP:0002179)1.95973461
119Menorrhagia (HP:0000132)1.94446070
120Achilles tendon contracture (HP:0001771)1.93510834
121Nephritis (HP:0000123)1.93093068
122Abnormalities of placenta or umbilical cord (HP:0001194)1.93069361
123Gingival bleeding (HP:0000225)1.92867126
124Reduced antithrombin III activity (HP:0001976)1.92601472
125Spinal rigidity (HP:0003306)1.92544397
126Ulnar bowing (HP:0003031)1.92087541
127Abnormality of alkaline phosphatase activity (HP:0004379)1.91955296
128Prolonged neonatal jaundice (HP:0006579)1.91846420
129Abnormality of methionine metabolism (HP:0010901)1.90916261
130Abnormal ossification of hand bones (HP:0005921)1.90856435
131Back pain (HP:0003418)1.90365004
132Beaking of vertebral bodies (HP:0004568)1.90037430
133Long toe (HP:0010511)1.89536337
134Aortic aneurysm (HP:0004942)1.88810789
135Entropion (HP:0000621)1.88769757
136Hemorrhage of the eye (HP:0011885)1.88333084
137Pterygium (HP:0001059)1.86914048
138Ovoid vertebral bodies (HP:0003300)1.86758019
139Microglossia (HP:0000171)1.86673287
140Abnormal cartilage morphology (HP:0002763)1.86438411
141Pancreatitis (HP:0001733)1.85671612
142Testicular atrophy (HP:0000029)1.84834990
143Generalized amyotrophy (HP:0003700)1.84546293
144Blue sclerae (HP:0000592)1.82381035
145Osteolytic defects of the hand bones (HP:0009699)1.81265853
146Osteolytic defects of the phalanges of the hand (HP:0009771)1.81265853
147Metabolic acidosis (HP:0001942)1.80657151
148Coxa vara (HP:0002812)1.80422810
149Abnormality of transition element cation homeostasis (HP:0011030)1.80321230
150Nuclear cataract (HP:0100018)1.79828728
151Abdominal distention (HP:0003270)1.79429013
152Spondylolisthesis (HP:0003302)1.78243973
153Joint stiffness (HP:0001387)1.78114279
154Insulin resistance (HP:0000855)1.78061649
155Soft skin (HP:0000977)1.77997977
156Flat acetabular roof (HP:0003180)1.77412937
157Rough bone trabeculation (HP:0100670)1.77376214
158Biconcave vertebral bodies (HP:0004586)1.77258380
159Abnormality of the pancreatic islet cells (HP:0006476)1.76945023
160Abnormality of endocrine pancreas physiology (HP:0012093)1.76945023
161Ankle contracture (HP:0006466)1.75317323
162White forelock (HP:0002211)1.74846779
163Patchy hypopigmentation of hair (HP:0011365)1.74455210
164Abnormal hand bone ossification (HP:0010660)1.72909899
165Skin nodule (HP:0200036)1.72138353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.22369249
2BCKDK3.52055049
3SIK12.88942666
4TRIB32.73149296
5INSRR2.60149131
6IRAK32.56268234
7LIMK12.55734271
8LMTK22.46725994
9KDR2.37140076
10FLT32.31771877
11PKN22.14297083
12FGFR42.03881954
13ARAF2.02875902
14EPHA22.01408374
15EIF2AK11.94345896
16MAPKAPK31.93934084
17PTK61.90306948
18VRK21.86689495
19BLK1.84549309
20MAP4K11.81827252
21TAOK31.75827231
22RIPK11.71178606
23NEK91.66475454
24MAP3K101.64750365
25TYK21.62492664
26IRAK41.61202465
27NTRK11.58039088
28TGFBR21.55083102
29ICK1.51334952
30MAP3K121.47561726
31JAK31.47123940
32NEK11.42634266
33ZAP701.41646921
34LRRK21.37167504
35PASK1.36392922
36SMG11.35945095
37MAP3K31.33904718
38PTK21.33631468
39PRKD21.31436198
40NME21.30568737
41TBK11.23882615
42CSK1.21727853
43MAPK151.21695772
44LATS11.19542554
45JAK11.18447277
46MST1R1.18339050
47STK101.17728009
48TIE11.15109940
49PIK3CG1.12644742
50MYLK1.12575736
51TEC1.11476849
52ERBB41.09496608
53EPHB11.07502120
54PDK21.07338063
55TTN1.06599361
56PRKCI1.03883969
57MAP2K31.03361549
58PTK2B1.01647577
59TESK11.01401500
60MAP3K141.00554587
61BTK0.99352844
62RPS6KA40.96153005
63TESK20.95858801
64CDK80.95607307
65PAK40.95500161
66MAP2K20.94661241
67BCR0.93420039
68PIM20.93053819
69PDGFRA0.92336271
70STK380.88927034
71KIT0.86358946
72IRAK10.86062755
73CSF1R0.85967170
74IKBKE0.84143724
75CDK70.83579557
76MET0.81313999
77PIK3CA0.79436974
78EEF2K0.78526680
79STK30.78100456
80TRPM70.77423307
81PRKD30.77002281
82PBK0.76359521
83EPHA30.75927542
84MUSK0.75512146
85DDR20.74375857
86CSNK1G30.73313523
87CSNK1A1L0.72568365
88MAP3K110.71311025
89DYRK1B0.71080657
90FRK0.70137816
91STK160.69835182
92ITK0.69731317
93PAK20.69547604
94ILK0.69141490
95BRSK10.68700426
96CDK90.65853005
97WNK40.65810687
98JAK20.63777831
99MAPK110.61215340
100SCYL20.61167359
101NLK0.58802466
102PRKG20.57151732
103CDK60.56834639
104GSK3A0.55943208
105CCNB10.55248443
106MOS0.54332342
107GRK10.53944106
108IKBKB0.53421284
109NUAK10.52968280
110CAMK2G0.52730591
111AURKA0.52590156
112STK240.52227708
113RPS6KA20.51767651
114CHUK0.50383379
115BUB10.49931853
116LYN0.49736546
117TXK0.49695723
118CSNK1G10.49157451
119EPHB20.48289965
120TAOK10.47957321
121TTK0.47743788
122AKT20.47379083
123MAPKAPK20.46566107
124BRSK20.45734593
125LATS20.44914727
126STK38L0.43341474
127MTOR0.42120581
128MAP3K80.41629395
129FER0.41154975
130EIF2AK30.39745212
131ROCK20.39705234
132ADRBK10.39650317
133IGF1R0.39235585
134LCK0.39231053
135ROCK10.39094242
136PAK10.39058797
137IRAK20.38696672
138PRKD10.38461756
139PDGFRB0.35923871
140ERBB20.35859520
141ABL20.35750362
142MST40.35471103
143STK40.35061216
144NME10.35028506
145TGFBR10.34536045
146CAMK2D0.33656762
147FGFR10.33371352
148GRK60.31697233
149CSNK1G20.31690111
150MAP3K70.31640100
151MAP2K10.30502585
152PRKCE0.26848717
153PLK20.26005475
154SRC0.25319468

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.05973926
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90523289
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.71296381
4Tryptophan metabolism_Homo sapiens_hsa003802.51209112
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48021512
6Fatty acid degradation_Homo sapiens_hsa000712.45047522
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25548531
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12579820
9Complement and coagulation cascades_Homo sapiens_hsa046102.12544872
10Proteasome_Homo sapiens_hsa030502.11183022
11Sulfur metabolism_Homo sapiens_hsa009202.07339640
12Selenocompound metabolism_Homo sapiens_hsa004501.85904862
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83443374
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80582168
15Protein export_Homo sapiens_hsa030601.80408168
16Peroxisome_Homo sapiens_hsa041461.79450103
17Folate biosynthesis_Homo sapiens_hsa007901.78784652
18Staphylococcus aureus infection_Homo sapiens_hsa051501.78702485
19Caffeine metabolism_Homo sapiens_hsa002321.77289970
20Histidine metabolism_Homo sapiens_hsa003401.75023726
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68294229
22Vibrio cholerae infection_Homo sapiens_hsa051101.58906192
23Nitrogen metabolism_Homo sapiens_hsa009101.58839724
24beta-Alanine metabolism_Homo sapiens_hsa004101.58562557
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.57938622
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56911158
27Fatty acid metabolism_Homo sapiens_hsa012121.51768498
28Fructose and mannose metabolism_Homo sapiens_hsa000511.51502935
29Arginine biosynthesis_Homo sapiens_hsa002201.51275208
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50117185
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48693176
32Chemical carcinogenesis_Homo sapiens_hsa052041.47394198
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47056105
34Starch and sucrose metabolism_Homo sapiens_hsa005001.45516337
35Propanoate metabolism_Homo sapiens_hsa006401.43719242
36PPAR signaling pathway_Homo sapiens_hsa033201.42343842
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41341342
38Fat digestion and absorption_Homo sapiens_hsa049751.40069183
39Sphingolipid metabolism_Homo sapiens_hsa006001.36115803
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.35449956
41Butanoate metabolism_Homo sapiens_hsa006501.34567121
42Other glycan degradation_Homo sapiens_hsa005111.33364895
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27787254
44Vitamin digestion and absorption_Homo sapiens_hsa049771.27476343
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26886668
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.26398338
47ABC transporters_Homo sapiens_hsa020101.24483824
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23906811
49Retinol metabolism_Homo sapiens_hsa008301.23748920
50Phenylalanine metabolism_Homo sapiens_hsa003601.15868016
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12710736
52Lysine degradation_Homo sapiens_hsa003101.11907490
53Sulfur relay system_Homo sapiens_hsa041221.11423620
54One carbon pool by folate_Homo sapiens_hsa006701.09955336
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.09623127
56Glutathione metabolism_Homo sapiens_hsa004801.07831894
57Fatty acid elongation_Homo sapiens_hsa000621.02204431
58Arginine and proline metabolism_Homo sapiens_hsa003300.99213863
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99197410
60Bile secretion_Homo sapiens_hsa049760.98621639
61Lysosome_Homo sapiens_hsa041420.97267068
62Tyrosine metabolism_Homo sapiens_hsa003500.96636696
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94469220
64Fatty acid biosynthesis_Homo sapiens_hsa000610.94145025
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93554075
66Protein digestion and absorption_Homo sapiens_hsa049740.91548775
67N-Glycan biosynthesis_Homo sapiens_hsa005100.86916859
68Pyruvate metabolism_Homo sapiens_hsa006200.86354110
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85445887
70Renin-angiotensin system_Homo sapiens_hsa046140.83217544
71Carbon metabolism_Homo sapiens_hsa012000.82455710
72Galactose metabolism_Homo sapiens_hsa000520.82056628
73Pyrimidine metabolism_Homo sapiens_hsa002400.79834800
74Vitamin B6 metabolism_Homo sapiens_hsa007500.77041462
75Pentose phosphate pathway_Homo sapiens_hsa000300.75110348
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74302230
77Steroid biosynthesis_Homo sapiens_hsa001000.73044094
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.71949234
79ECM-receptor interaction_Homo sapiens_hsa045120.66801473
80Base excision repair_Homo sapiens_hsa034100.66663826
81Biosynthesis of amino acids_Homo sapiens_hsa012300.65665517
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63793536
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63299759
84Leishmaniasis_Homo sapiens_hsa051400.55631621
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.54958906
86Insulin resistance_Homo sapiens_hsa049310.53562464
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53426456
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53005550
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52487076
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.51876753
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51584105
92Antigen processing and presentation_Homo sapiens_hsa046120.51128588
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50742512
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50534143
95Legionellosis_Homo sapiens_hsa051340.50263324
96Proteoglycans in cancer_Homo sapiens_hsa052050.48500520
97Malaria_Homo sapiens_hsa051440.48348582
98Glycerolipid metabolism_Homo sapiens_hsa005610.47552782
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46526062
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46426023
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.45523916
102Hematopoietic cell lineage_Homo sapiens_hsa046400.42440380
103Metabolic pathways_Homo sapiens_hsa011000.40795904
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.40028261
105Small cell lung cancer_Homo sapiens_hsa052220.37667600
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36293737
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35782669
108Pertussis_Homo sapiens_hsa051330.35776106
109Notch signaling pathway_Homo sapiens_hsa043300.34399563
110Mineral absorption_Homo sapiens_hsa049780.33732189
111Huntingtons disease_Homo sapiens_hsa050160.33716602
112Hippo signaling pathway_Homo sapiens_hsa043900.33555452
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33485967
114Toxoplasmosis_Homo sapiens_hsa051450.33397276
115Prion diseases_Homo sapiens_hsa050200.33336369
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31804461
117Basal cell carcinoma_Homo sapiens_hsa052170.31670611
118Measles_Homo sapiens_hsa051620.29893259
119Amoebiasis_Homo sapiens_hsa051460.29796291
120Bladder cancer_Homo sapiens_hsa052190.27399745
121Focal adhesion_Homo sapiens_hsa045100.26267033
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26219015
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.25896732
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22445832
125Arachidonic acid metabolism_Homo sapiens_hsa005900.22322159
126Hepatitis C_Homo sapiens_hsa051600.20476976
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19991817

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