TM9SF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.19851657
2COPI coating of Golgi vesicle (GO:0048205)6.19851657
3L-phenylalanine catabolic process (GO:0006559)4.74207991
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.74207991
5L-phenylalanine metabolic process (GO:0006558)4.57950392
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.57950392
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.56998240
8alpha-linolenic acid metabolic process (GO:0036109)4.33539309
9cysteine metabolic process (GO:0006534)4.32188385
10COPII vesicle coating (GO:0048208)4.25286526
11protein retention in ER lumen (GO:0006621)4.15072815
12sulfur amino acid catabolic process (GO:0000098)4.05123019
13angiotensin maturation (GO:0002003)3.95012510
14very-low-density lipoprotein particle assembly (GO:0034379)3.81612934
15lysine metabolic process (GO:0006553)3.81362453
16lysine catabolic process (GO:0006554)3.81362453
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.71166721
18glycosphingolipid catabolic process (GO:0046479)3.64130900
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.62956547
20glycolipid catabolic process (GO:0019377)3.60361927
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.54386043
22intestinal cholesterol absorption (GO:0030299)3.52316197
23exocrine pancreas development (GO:0031017)3.49612654
24regulation of cholesterol homeostasis (GO:2000188)3.49271458
25aromatic amino acid family catabolic process (GO:0009074)3.48798360
26UDP-N-acetylglucosamine metabolic process (GO:0006047)3.46042457
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.45821664
28intestinal absorption (GO:0050892)3.45494585
294-hydroxyproline metabolic process (GO:0019471)3.43268316
30cell adhesion mediated by integrin (GO:0033627)3.35214593
31desmosome organization (GO:0002934)3.35000855
32drug transmembrane transport (GO:0006855)3.32828929
33negative regulation of protein activation cascade (GO:2000258)3.31771590
34positive regulation of nuclease activity (GO:0032075)3.28613629
35negative regulation of complement activation (GO:0045916)3.27973898
36L-serine transport (GO:0015825)3.26886592
37protein carboxylation (GO:0018214)3.26101190
38peptidyl-glutamic acid carboxylation (GO:0017187)3.26101190
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23288720
40homocysteine metabolic process (GO:0050667)3.21642910
41bile acid biosynthetic process (GO:0006699)3.21009878
42ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.18620407
43glyoxylate metabolic process (GO:0046487)3.18364818
44reverse cholesterol transport (GO:0043691)3.16608278
45cellular modified amino acid catabolic process (GO:0042219)3.15028041
46valine metabolic process (GO:0006573)3.12727315
47phospholipid efflux (GO:0033700)3.12610029
48negative regulation of fibrinolysis (GO:0051918)3.10317867
49cellular glucuronidation (GO:0052695)3.08059667
50negative regulation of humoral immune response (GO:0002921)3.07157200
51membrane budding (GO:0006900)3.06403457
52bile acid metabolic process (GO:0008206)3.06247586
53ceramide catabolic process (GO:0046514)3.06196063
54endoplasmic reticulum unfolded protein response (GO:0030968)3.04217351
55regulation of protein activation cascade (GO:2000257)3.04164368
56negative regulation of protein localization to plasma membrane (GO:1903077)3.03293073
57fatty acid beta-oxidation (GO:0006635)2.99901564
58high-density lipoprotein particle remodeling (GO:0034375)2.99821790
59glucuronate metabolic process (GO:0019585)2.99687224
60uronic acid metabolic process (GO:0006063)2.99687224
61positive regulation of glycoprotein metabolic process (GO:1903020)2.99005357
62negative regulation of sterol transport (GO:0032372)2.97380468
63negative regulation of cholesterol transport (GO:0032375)2.97380468
64fatty acid oxidation (GO:0019395)2.97075316
65NADH metabolic process (GO:0006734)2.95501438
66amyloid precursor protein catabolic process (GO:0042987)2.95295777
67glycoside metabolic process (GO:0016137)2.94861097
68regulation of complement activation (GO:0030449)2.94327833
69cellular response to unfolded protein (GO:0034620)2.92856526
70membrane protein ectodomain proteolysis (GO:0006509)2.92702322
71vesicle coating (GO:0006901)2.91908817
72short-chain fatty acid metabolic process (GO:0046459)2.91630434
73regulation of nuclease activity (GO:0032069)2.91317155
74lipoprotein metabolic process (GO:0042157)2.91196333
75lipid oxidation (GO:0034440)2.91186180
76signal peptide processing (GO:0006465)2.91002627
77complement activation, alternative pathway (GO:0006957)2.89779222
78peptide catabolic process (GO:0043171)2.89500215
79transcytosis (GO:0045056)2.87791790
80peptide hormone processing (GO:0016486)2.87619655
81positive regulation of glycolytic process (GO:0045821)2.87366833
82ER-nucleus signaling pathway (GO:0006984)2.86878228
83bile acid and bile salt transport (GO:0015721)2.86709435
84aspartate family amino acid catabolic process (GO:0009068)2.84898570
85intestinal epithelial cell development (GO:0060576)2.83453701
86regulation of cholesterol biosynthetic process (GO:0045540)2.82761883
87fatty acid catabolic process (GO:0009062)2.82352928
88nucleotide-sugar biosynthetic process (GO:0009226)2.81491378
89sequestering of metal ion (GO:0051238)2.81348552
90protein N-linked glycosylation via asparagine (GO:0018279)2.81078819
91sphingolipid catabolic process (GO:0030149)2.80113427
92endocrine pancreas development (GO:0031018)2.79773629
93positive regulation of fatty acid biosynthetic process (GO:0045723)2.79326470
94membrane lipid catabolic process (GO:0046466)2.79251465
95sphingomyelin metabolic process (GO:0006684)2.79064140
96tricarboxylic acid metabolic process (GO:0072350)2.79036364
97regulation of fibrinolysis (GO:0051917)2.78689233
98lung epithelium development (GO:0060428)2.78291962
99negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.77968642
100cellular response to topologically incorrect protein (GO:0035967)2.77907974
101cellular ketone body metabolic process (GO:0046950)2.77900833
102peptidyl-asparagine modification (GO:0018196)2.77755127
103long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77735221
104amino-acid betaine metabolic process (GO:0006577)2.77429085
105regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.75900599
106oligosaccharide biosynthetic process (GO:0009312)2.75545878
107keratan sulfate catabolic process (GO:0042340)2.74706006
108regulation of transforming growth factor beta1 production (GO:0032908)2.73875786
109protein maturation by protein folding (GO:0022417)2.73853049
110fat-soluble vitamin biosynthetic process (GO:0042362)2.73588535
111plasma lipoprotein particle clearance (GO:0034381)2.73522395
112regulation of triglyceride catabolic process (GO:0010896)2.73141905
113kynurenine metabolic process (GO:0070189)2.72279387
114triglyceride homeostasis (GO:0070328)2.72032502
115acylglycerol homeostasis (GO:0055090)2.72032502
116ER to Golgi vesicle-mediated transport (GO:0006888)2.71733849
117urea metabolic process (GO:0019627)2.71726383
118urea cycle (GO:0000050)2.71726383
119primary alcohol catabolic process (GO:0034310)2.71286566
120drug transport (GO:0015893)2.70535570
121pyrimidine-containing compound transmembrane transport (GO:0072531)2.70081351
122serine transport (GO:0032329)2.70051129
123response to mercury ion (GO:0046689)2.69502522
124apoptotic cell clearance (GO:0043277)2.68487560
125ethanol oxidation (GO:0006069)2.67590433
126protein-lipid complex assembly (GO:0065005)2.67572821
127protein N-linked glycosylation (GO:0006487)2.67369318
1282-oxoglutarate metabolic process (GO:0006103)2.67293900
129glutamate metabolic process (GO:0006536)2.66891089
130nitrogen cycle metabolic process (GO:0071941)2.65667159
131lipoprotein transport (GO:0042953)2.65495086
132regulation of cholesterol metabolic process (GO:0090181)2.64821352
133drug catabolic process (GO:0042737)2.64104014
134plasma lipoprotein particle remodeling (GO:0034369)2.63304304
135protein-lipid complex remodeling (GO:0034368)2.63304304
136macromolecular complex remodeling (GO:0034367)2.63304304
137oligosaccharide catabolic process (GO:0009313)2.63155142
138cellular copper ion homeostasis (GO:0006878)2.62369113
139positive regulation of fatty acid beta-oxidation (GO:0032000)2.62294999
140toxin metabolic process (GO:0009404)2.62218806
141positive regulation of triglyceride metabolic process (GO:0090208)2.61470424
142monocarboxylic acid catabolic process (GO:0072329)2.61318034
143protein localization to endosome (GO:0036010)2.61001105
144regulation of cholesterol esterification (GO:0010872)2.59258903
145beta-amyloid metabolic process (GO:0050435)2.59180908
146response to endoplasmic reticulum stress (GO:0034976)2.58703427
147regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.58122440
148maintenance of gastrointestinal epithelium (GO:0030277)2.57977575
149iron ion import (GO:0097286)2.57588004
150long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.56537471
151vitamin transmembrane transport (GO:0035461)2.56368314
152low-density lipoprotein particle clearance (GO:0034383)2.55617272
153epoxygenase P450 pathway (GO:0019373)2.55590865
154regulation of Golgi to plasma membrane protein transport (GO:0042996)2.55221696
155plasma lipoprotein particle assembly (GO:0034377)2.54770435
156ethanol metabolic process (GO:0006067)2.52897727
157cholesterol efflux (GO:0033344)2.52667044
158hemidesmosome assembly (GO:0031581)2.51733427
159very long-chain fatty acid metabolic process (GO:0000038)2.51115720
160zinc ion transport (GO:0006829)2.50565818
161regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.45827147
162polyketide metabolic process (GO:0030638)2.43384071
163doxorubicin metabolic process (GO:0044598)2.43384071
164daunorubicin metabolic process (GO:0044597)2.43384071
165nucleotide transmembrane transport (GO:1901679)2.41339491
166amyloid precursor protein metabolic process (GO:0042982)2.39736984
167positive regulation of glycoprotein biosynthetic process (GO:0010560)2.39522262
168mRNA modification (GO:0016556)2.37445543
169phospholipid homeostasis (GO:0055091)2.36664767
170fatty-acyl-CoA biosynthetic process (GO:0046949)2.36373256
171calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.35536981
172nucleotide-sugar metabolic process (GO:0009225)2.34597743
173polyol transport (GO:0015791)2.32918206
174regulation of apoptotic cell clearance (GO:2000425)2.32701970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.16598017
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.26914913
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.63553899
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.39779141
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75705039
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.66242945
7CLOCK_20551151_ChIP-Seq_293T_Human3.65146819
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.13829983
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.08578837
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96799321
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.93013143
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.52963859
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.44856509
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44296042
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.37492188
16SOX2_27498859_Chip-Seq_STOMACH_Mouse2.31412974
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26299823
18GATA1_22025678_ChIP-Seq_K562_Human2.13657914
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10776074
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.09285069
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99013969
22SOX2_20726797_ChIP-Seq_SW620_Human1.97330933
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.96201611
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92852168
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.87317693
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85414713
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83290119
28* GATA4_25053715_ChIP-Seq_YYC3_Human1.82858369
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.82001117
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78319149
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68009032
32ZNF263_19887448_ChIP-Seq_K562_Human1.66927849
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.66683040
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63049227
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.62325771
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57737775
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56393824
38* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50452764
39* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49970641
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49292645
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47359695
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47359695
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44262009
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.41813234
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.41711177
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.40306522
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39390566
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36883960
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36183870
50TFEB_21752829_ChIP-Seq_HELA_Human1.33822968
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32803803
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29773124
53ELK1_19687146_ChIP-ChIP_HELA_Human1.29475964
54* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27559193
55* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27368723
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27266388
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26305902
58* GATA6_25053715_ChIP-Seq_YYC3_Human1.25311148
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24972029
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.24795501
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24281143
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23938377
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.23937511
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20792778
65CJUN_26792858_Chip-Seq_BT549_Human1.18860529
66* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18787205
67FOXA1_25552417_ChIP-Seq_VCAP_Human1.17719265
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14509342
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14195618
70* ELF5_23300383_ChIP-Seq_T47D_Human1.12996032
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12376434
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10482222
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10383689
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09521774
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09364701
76* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08179082
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.07748960
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05833024
79AR_21909140_ChIP-Seq_LNCAP_Human1.04626345
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04458526
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.03674761
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03672516
83* HNF4A_19822575_ChIP-Seq_HepG2_Human1.03049668
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.01346439
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.01296685
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.01296685
87BRD4_25478319_ChIP-Seq_HGPS_Human1.00799544
88* ATF3_27146783_Chip-Seq_COLON_Human1.00722660
89GATA1_19941826_ChIP-Seq_K562_Human1.00160245
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99136308
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.98596354
92* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98542273
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97648347
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97261332
95BCAT_22108803_ChIP-Seq_LS180_Human0.96882576
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96222022
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96126784
98* RACK7_27058665_Chip-Seq_MCF-7_Human0.94741676
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93867984
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93723055
101EOMES_21245162_ChIP-Seq_HESCs_Human0.92864254
102HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92552358
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91442435
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91254803
105* RUNX1_27514584_Chip-Seq_MCF-7_Human0.90661569
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90545310
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90278434
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90036327
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90011329
110P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87678006
111* TP63_23658742_ChIP-Seq_EP156T_Human0.86917334
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84930569
113GATA2_19941826_ChIP-Seq_K562_Human0.84816054
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.84141973
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83574345
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.83189760
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82214280
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82036834
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81698740
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.81128069
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81120328
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79453734
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79410161
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77836883
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77034742
126LXR_22292898_ChIP-Seq_THP-1_Human0.75744699
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75458831
128CDX2_22108803_ChIP-Seq_LS180_Human0.72302137
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.70291603
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69797486
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68000132
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.67852158
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67384904
134SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67384904
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.66468756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.23106451
2MP0005360_urolithiasis4.69474132
3MP0005365_abnormal_bile_salt4.28835400
4MP0005085_abnormal_gallbladder_physiolo3.63524995
5MP0008875_abnormal_xenobiotic_pharmacok3.16012392
6MP0003195_calcinosis3.10269839
7MP0001666_abnormal_nutrient_absorption2.96226620
8MP0010234_abnormal_vibrissa_follicle2.77040871
9MP0009780_abnormal_chondrocyte_physiolo2.71010574
10MP0003252_abnormal_bile_duct2.67999797
11MP0009840_abnormal_foam_cell2.46659615
12MP0003300_gastrointestinal_ulcer2.41773820
13MP0003283_abnormal_digestive_organ2.32060039
14MP0004782_abnormal_surfactant_physiolog2.31979407
15MP0003806_abnormal_nucleotide_metabolis2.31716576
16MP0010329_abnormal_lipoprotein_level2.26693325
17MP0003941_abnormal_skin_development2.19597287
18MP0008438_abnormal_cutaneous_collagen2.17469426
19MP0004043_abnormal_pH_regulation2.15403380
20MP0005332_abnormal_amino_acid2.11810457
21MP0006054_spinal_hemorrhage2.10974497
22MP0003705_abnormal_hypodermis_morpholog2.05657624
23MP0002009_preneoplasia2.04761452
24MP0004264_abnormal_extraembryonic_tissu2.01138800
25MP0005083_abnormal_biliary_tract1.99033751
26MP0005220_abnormal_exocrine_pancreas1.97066320
27MP0000013_abnormal_adipose_tissue1.94911015
28MP0002138_abnormal_hepatobiliary_system1.90155334
29MP0009384_cardiac_valve_regurgitation1.90006398
30MP0010368_abnormal_lymphatic_system1.87207135
31MP0009643_abnormal_urine_homeostasis1.84661302
32MP0008260_abnormal_autophagy1.77366607
33MP0002796_impaired_skin_barrier1.74850299
34MP0003868_abnormal_feces_composition1.71493293
35MP0008004_abnormal_stomach_pH1.71277846
36MP0005058_abnormal_lysosome_morphology1.69871635
37MP0002166_altered_tumor_susceptibility1.66466337
38MP0003191_abnormal_cellular_cholesterol1.65165810
39MP0003183_abnormal_peptide_metabolism1.60085366
40MP0004272_abnormal_basement_membrane1.56832036
41MP0002909_abnormal_adrenal_gland1.53026104
42MP0000462_abnormal_digestive_system1.52877818
43MP0002118_abnormal_lipid_homeostasis1.52172170
44MP0001944_abnormal_pancreas_morphology1.45942437
45MP0000609_abnormal_liver_physiology1.44661993
46MP0003329_amyloid_beta_deposits1.40162200
47MP0002877_abnormal_melanocyte_morpholog1.39602287
48MP0004019_abnormal_vitamin_homeostasis1.37540136
49MP0000465_gastrointestinal_hemorrhage1.34797693
50MP0002098_abnormal_vibrissa_morphology1.34587610
51MP0003172_abnormal_lysosome_physiology1.32808936
52MP0006082_CNS_inflammation1.31350216
53MP0001765_abnormal_ion_homeostasis1.29810083
54MP0000604_amyloidosis1.29076159
55MP0002254_reproductive_system_inflammat1.25439463
56MP0001756_abnormal_urination1.22830756
57MP0005275_abnormal_skin_tensile1.21910061
58MP0005636_abnormal_mineral_homeostasis1.18818961
59MP0002896_abnormal_bone_mineralization1.18481075
60MP0003950_abnormal_plasma_membrane1.18459636
61MP0002837_dystrophic_cardiac_calcinosis1.17161863
62MP0002006_tumorigenesis1.12565132
63MP0010155_abnormal_intestine_physiology1.12397753
64MP0002090_abnormal_vision1.11638370
65MP0005319_abnormal_enzyme/_coenzyme1.10245335
66MP0001958_emphysema1.09971609
67MP0005409_darkened_coat_color1.08539534
68MP0002078_abnormal_glucose_homeostasis1.07866200
69MP0001661_extended_life_span1.07388744
70MP0001216_abnormal_epidermal_layer1.06342336
71MP0000003_abnormal_adipose_tissue1.06221428
72MP0002693_abnormal_pancreas_physiology1.04975666
73MP0001915_intracranial_hemorrhage1.03570181
74MP0005248_abnormal_Harderian_gland1.01319791
75MP0005084_abnormal_gallbladder_morpholo1.01102306
76MP0005501_abnormal_skin_physiology0.99265717
77MP0005408_hypopigmentation0.95158677
78MP0003221_abnormal_cardiomyocyte_apopto0.94707558
79MP0009697_abnormal_copulation0.92099787
80MP0000383_abnormal_hair_follicle0.91841178
81MP0001764_abnormal_homeostasis0.90914495
82MP0005584_abnormal_enzyme/coenzyme_acti0.89438362
83MP0003566_abnormal_cell_adhesion0.89069038
84MP0000377_abnormal_hair_follicle0.88191033
85MP0000537_abnormal_urethra_morphology0.87038506
86MP0000627_abnormal_mammary_gland0.84541403
87MP0005164_abnormal_response_to0.84134917
88MP0003656_abnormal_erythrocyte_physiolo0.83909920
89MP0003724_increased_susceptibility_to0.82613080
90MP0000490_abnormal_crypts_of0.82005931
91MP0004130_abnormal_muscle_cell0.81998943
92MP0002928_abnormal_bile_duct0.81697540
93MP0009053_abnormal_anal_canal0.80773001
94MP0002136_abnormal_kidney_physiology0.80594339
95MP0005310_abnormal_salivary_gland0.80572931
96MP0000477_abnormal_intestine_morphology0.79379632
97MP0002295_abnormal_pulmonary_circulatio0.79335540
98MP0010386_abnormal_urinary_bladder0.79037229
99MP0004185_abnormal_adipocyte_glucose0.76358724
100MP0000566_synostosis0.76310399
101MP0008961_abnormal_basal_metabolism0.76093541
102MP0010352_gastrointestinal_tract_polyps0.75428928
103MP0005381_digestive/alimentary_phenotyp0.75250402
104MP0002168_other_aberrant_phenotype0.74446522
105MP0005375_adipose_tissue_phenotype0.74370174
106MP0010678_abnormal_skin_adnexa0.74301763
107MP0000538_abnormal_urinary_bladder0.72714127
108MP0001299_abnormal_eye_distance/0.71416631
109MP0000598_abnormal_liver_morphology0.71256279
110MP0005023_abnormal_wound_healing0.70899398
111MP0004883_abnormal_blood_vessel0.70527670
112MP0001873_stomach_inflammation0.70358626
113MP0003186_abnormal_redox_activity0.70352760
114MP0005367_renal/urinary_system_phenotyp0.69577566
115MP0000516_abnormal_urinary_system0.69577566
116MP0003448_altered_tumor_morphology0.68882391
117MP0001879_abnormal_lymphatic_vessel0.67995197
118MP0005166_decreased_susceptibility_to0.67990772
119MP0001664_abnormal_digestion0.67647607
120MP0003959_abnormal_lean_body0.67210344
121MP0005666_abnormal_adipose_tissue0.66746773
122MP0001270_distended_abdomen0.66032131
123MP0000467_abnormal_esophagus_morphology0.65244188
124MP0009642_abnormal_blood_homeostasis0.65217931
125MP0003890_abnormal_embryonic-extraembry0.65077349
126MP0000230_abnormal_systemic_arterial0.64952444
127MP0002060_abnormal_skin_morphology0.63943689
128MP0000858_altered_metastatic_potential0.63936664
129MP0000613_abnormal_salivary_gland0.63765574
130MP0000639_abnormal_adrenal_gland0.62576452
131MP0008469_abnormal_protein_level0.62446857
132MP0005379_endocrine/exocrine_gland_phen0.61444052
133MP0003091_abnormal_cell_migration0.61063337
134MP0005165_increased_susceptibility_to0.60886688
135MP0003075_altered_response_to0.60608998
136MP0009785_altered_susceptibility_to0.59858199
137MP0000163_abnormal_cartilage_morphology0.59352902
138MP0001881_abnormal_mammary_gland0.59060181
139MP0005257_abnormal_intraocular_pressure0.58667555
140MP0003453_abnormal_keratinocyte_physiol0.57978304
141MP0005451_abnormal_body_composition0.57644264
142MP0002133_abnormal_respiratory_system0.57620367
143MP0005388_respiratory_system_phenotype0.57620367
144MP0002971_abnormal_brown_adipose0.56479489
145MP0002419_abnormal_innate_immunity0.56321220
146MP0004957_abnormal_blastocyst_morpholog0.56263926

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.81035806
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.52158005
3Intrahepatic cholestasis (HP:0001406)4.40830382
4Xanthomatosis (HP:0000991)4.04642672
5Deep venous thrombosis (HP:0002625)3.99829003
6Ketoacidosis (HP:0001993)3.98286117
7Hypoglycemic seizures (HP:0002173)3.91803074
8Hyperinsulinemic hypoglycemia (HP:0000825)3.82505550
9Ketosis (HP:0001946)3.54306809
10Loss of speech (HP:0002371)3.39395834
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.38465937
12Hypobetalipoproteinemia (HP:0003563)3.20218458
13Abnormality of the intrinsic pathway (HP:0010989)3.19724920
14Systemic lupus erythematosus (HP:0002725)3.18278528
15Abnormality of liposaccharide metabolism (HP:0010968)3.15893983
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.15893983
17Abnormality of glycolipid metabolism (HP:0010969)3.15893983
18Abnormality of the common coagulation pathway (HP:0010990)3.14542010
19Fat malabsorption (HP:0002630)3.11954012
20Symptomatic seizures (HP:0011145)3.11399970
21Tetraparesis (HP:0002273)3.10027959
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.08375503
23Gout (HP:0001997)2.98199600
24Late onset (HP:0003584)2.90865561
25Complement deficiency (HP:0004431)2.89248858
26Dysostosis multiplex (HP:0000943)2.87649648
27Hyperglycemia (HP:0003074)2.80094200
28Glomerulonephritis (HP:0000099)2.80039843
29Mucopolysacchariduria (HP:0008155)2.77044622
30Urinary glycosaminoglycan excretion (HP:0003541)2.77044622
31Hypolipoproteinemia (HP:0010981)2.75908397
32Hyperammonemia (HP:0001987)2.72806703
33Abnormality of purine metabolism (HP:0004352)2.63735992
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.62362351
35Flat acetabular roof (HP:0003180)2.58343552
36Hyperlipoproteinemia (HP:0010980)2.57959622
37Hypoalphalipoproteinemia (HP:0003233)2.57803875
38Prolonged partial thromboplastin time (HP:0003645)2.53960785
39Abdominal distention (HP:0003270)2.53791905
40Osteolytic defects of the hand bones (HP:0009699)2.53396823
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.53396823
42Conjugated hyperbilirubinemia (HP:0002908)2.52216418
43Abnormality of the pancreatic islet cells (HP:0006476)2.50710425
44Abnormality of endocrine pancreas physiology (HP:0012093)2.50710425
45Papillary thyroid carcinoma (HP:0002895)2.49614706
46Abnormality of fatty-acid metabolism (HP:0004359)2.47281249
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46821906
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46821906
49Abnormality of polysaccharide metabolism (HP:0011012)2.46821906
50Protuberant abdomen (HP:0001538)2.46048080
51Abnormality of the distal phalanges of the toes (HP:0010182)2.45498905
52Lower limb hyperreflexia (HP:0002395)2.43485169
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43399575
54Generalized aminoaciduria (HP:0002909)2.43137118
55Hyperglycinuria (HP:0003108)2.41488967
56Abnormality of glycine metabolism (HP:0010895)2.35469850
57Abnormality of serine family amino acid metabolism (HP:0010894)2.35469850
58Hydroxyprolinuria (HP:0003080)2.34214072
59Abnormality of proline metabolism (HP:0010907)2.34214072
60Skin nodule (HP:0200036)2.34164570
61Esophageal varix (HP:0002040)2.33910637
62Vacuolated lymphocytes (HP:0001922)2.33579932
63Malnutrition (HP:0004395)2.33475052
64Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31972120
65Reduced antithrombin III activity (HP:0001976)2.31804810
66Epidermoid cyst (HP:0200040)2.25753149
67Protrusio acetabuli (HP:0003179)2.25382584
68Aortic aneurysm (HP:0004942)2.25225233
69Hyperactive renin-angiotensin system (HP:0000841)2.24109356
70Abnormality of complement system (HP:0005339)2.24102259
71Steatorrhea (HP:0002570)2.23929303
72Pancreatic islet-cell hyperplasia (HP:0004510)2.23897350
73Periodontitis (HP:0000704)2.21720055
74Back pain (HP:0003418)2.21493293
75Abnormality of sulfur amino acid metabolism (HP:0004339)2.19842374
76Premature rupture of membranes (HP:0001788)2.18193725
77Right ventricular cardiomyopathy (HP:0011663)2.16337579
78Aortic dissection (HP:0002647)2.14787633
79Disinhibition (HP:0000734)2.14578227
80Chronic diarrhea (HP:0002028)2.13835540
81Alopecia of scalp (HP:0002293)2.13599452
82Insulin resistance (HP:0000855)2.10056187
83Cervical subluxation (HP:0003308)2.09570686
84Abnormal foot bone ossification (HP:0010675)2.09106011
85Neurofibrillary tangles (HP:0002185)2.08668243
86Proximal tubulopathy (HP:0000114)2.05032611
87Amyloidosis (HP:0011034)2.02956983
88Myocardial infarction (HP:0001658)2.02614822
89Curly hair (HP:0002212)2.00314633
90Progressive neurologic deterioration (HP:0002344)2.00151565
91Vertebral compression fractures (HP:0002953)1.99566637
92Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98895825
93Aneurysm (HP:0002617)1.98735680
94Insulin-resistant diabetes mellitus (HP:0000831)1.96118423
95Plantar hyperkeratosis (HP:0007556)1.95359511
96Beaking of vertebral bodies (HP:0004568)1.94375888
97Hyperglycinemia (HP:0002154)1.94369540
98Sensorimotor neuropathy (HP:0007141)1.94341719
99Bilateral sensorineural hearing impairment (HP:0008619)1.93717841
100Abnormality of chloride homeostasis (HP:0011422)1.93627199
101Facial shape deformation (HP:0011334)1.93286150
102Potter facies (HP:0002009)1.93286150
103Abnormal protein glycosylation (HP:0012346)1.92906562
104Abnormal glycosylation (HP:0012345)1.92906562
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92906562
106Abnormal protein N-linked glycosylation (HP:0012347)1.92906562
107Gingival bleeding (HP:0000225)1.92506817
108Abnormal tarsal ossification (HP:0008369)1.89915430
109Retinal atrophy (HP:0001105)1.88996083
110Hyperbilirubinemia (HP:0002904)1.88950598
111Abnormality of nucleobase metabolism (HP:0010932)1.88067148
112Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87857278
113Abnormality of macrophages (HP:0004311)1.87740873
114Pili torti (HP:0003777)1.87105428
115Eczematoid dermatitis (HP:0000976)1.86601977
116Irritability (HP:0000737)1.85620546
117Cerebral inclusion bodies (HP:0100314)1.85289203
118Termporal pattern (HP:0011008)1.84797556
119Insidious onset (HP:0003587)1.84797556
120Acanthocytosis (HP:0001927)1.84237806
121Palmar hyperkeratosis (HP:0010765)1.83157966
122Patchy hypopigmentation of hair (HP:0011365)1.82789620
123Cerebral aneurysm (HP:0004944)1.82126437
124Increased purine levels (HP:0004368)1.82031150
125Hyperuricemia (HP:0002149)1.82031150
126Abnormal biliary tract morphology (HP:0012440)1.82002733
127Short nail (HP:0001799)1.81622063
128Vascular tortuosity (HP:0004948)1.80820702
129Abnormality of the lumbar spine (HP:0100712)1.80455196
130Hypotension (HP:0002615)1.80214383
131Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80166743
132Dicarboxylic aciduria (HP:0003215)1.80166743
133Long toe (HP:0010511)1.79671045
134Cardiovascular calcification (HP:0011915)1.79654729
135Elevated alkaline phosphatase (HP:0003155)1.79628747
136Abnormal enzyme/coenzyme activity (HP:0012379)1.79237066
137Hypokalemic alkalosis (HP:0001949)1.79236296
138Widely patent fontanelles and sutures (HP:0004492)1.78854807
139Palmoplantar hyperkeratosis (HP:0000972)1.78036641
140Abnormal cartilage morphology (HP:0002763)1.77607313
141Rhinitis (HP:0012384)1.76991416
142Hypercholesterolemia (HP:0003124)1.76522532
143Abnormality of the costochondral junction (HP:0000919)1.76237850
144Abnormality of vitamin metabolism (HP:0100508)1.74786784
145Abnormality of alkaline phosphatase activity (HP:0004379)1.74777261
146Arterial tortuosity (HP:0005116)1.74634300
147Vertebral hypoplasia (HP:0008417)1.74417105
148Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74417105
149Vascular calcification (HP:0004934)1.73474360
150Mitral stenosis (HP:0001718)1.72907995
151Recurrent abscess formation (HP:0002722)1.72555500
152Increased CSF protein (HP:0002922)1.72469779
153Hand muscle atrophy (HP:0009130)1.72025678
154Increased serum pyruvate (HP:0003542)1.71615860
155Nephritis (HP:0000123)1.71437385
156Distal upper limb amyotrophy (HP:0007149)1.71133626
157Upper limb amyotrophy (HP:0009129)1.71133626
158Pathologic fracture (HP:0002756)1.69665925
159Abnormality of glycolysis (HP:0004366)1.68826695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.94788979
2FRK3.70772523
3EIF2AK33.40877567
4INSRR3.19428744
5BCKDK2.83876504
6MAPK152.79019638
7TAOK32.74023559
8BCR2.69271963
9EIF2AK12.61901791
10TRIB32.53137354
11MAP3K122.38576127
12MAP3K22.29970426
13WNK42.27267864
14SCYL22.17996916
15ERBB32.17068358
16SIK11.97277264
17FGFR41.96930969
18KSR21.93185007
19LATS11.92212886
20PKN21.92189180
21PTK61.90120869
22PDGFRA1.89967053
23TRIM281.88447132
24LMTK21.87233102
25MET1.86663211
26FLT31.81795223
27TSSK61.79425256
28EPHB11.70425479
29MST1R1.69519869
30YES11.64649808
31STK241.63711122
32PTK21.56250261
33MAP4K21.42414640
34STK38L1.42412704
35NTRK11.42013720
36PBK1.41243200
37FGFR31.39179517
38PASK1.38448218
39PIK3CG1.37141426
40FER1.36527757
41WNK31.35441482
42STK391.34041081
43TESK11.30807159
44TGFBR21.29943465
45TTK1.29674084
46CDK61.25834847
47EPHA21.25142483
48RIPK11.25105165
49MST41.20071170
50MAP3K11.17039712
51TIE11.16130419
52LRRK21.15483255
53EPHA31.14816058
54PAK31.10618604
55DDR21.09244318
56PRKG21.05968013
57NEK11.05736091
58CAMKK21.03084508
59NEK91.02448883
60SRPK11.01887789
61AKT31.01383877
62RET0.99973893
63HIPK20.98871610
64FGFR20.97848266
65KDR0.97509418
66DYRK1B0.96041027
67PDK40.94374787
68PDK30.94374787
69MAPKAPK30.91942381
70CSNK1G30.91741163
71OXSR10.90237408
72BMPR20.89943890
73MAP2K10.89814939
74CLK10.88804830
75TTN0.88644876
76CSNK1G10.88356778
77MAP2K20.87827578
78TAOK10.83056323
79EPHB20.81830409
80CSNK1A1L0.79612063
81SIK30.79339591
82ERBB40.78567966
83JAK20.78326031
84MAP3K30.77635699
85PRKD30.77409129
86PLK20.72149668
87MAP3K140.72044314
88MAP3K50.71680121
89CSNK1G20.71208103
90PAK20.71005239
91FGR0.69225764
92PAK40.68768150
93MAP3K60.68603474
94MATK0.68412829
95NEK60.67370459
96FGFR10.64060639
97JAK30.63023473
98PDK20.62532803
99CSK0.62126950
100JAK10.60689117
101LIMK10.60217038
102RPS6KA40.58842807
103MAPK110.57158505
104NLK0.56763588
105IRAK10.56538480
106IGF1R0.55990128
107STK100.55824362
108ITK0.54556750
109MOS0.54460583
110PDGFRB0.54101018
111PRKCE0.53964307
112CAMK1D0.53621239
113GSK3A0.51624369
114PRKAA20.51560200
115MAP3K130.50912850
116NUAK10.50782655
117MYLK0.49428500
118BLK0.48082840
119TYK20.45179843
120MELK0.44705354
121EGFR0.42497505
122KSR10.42198468
123TGFBR10.40530860
124TRPM70.40185404
125ARAF0.40006697
126MAP3K90.37865997
127PDPK10.36730507
128TBK10.35134895
129PRKCI0.34942462
130PRKCH0.34727154
131MAP3K80.34706473
132BRSK20.34097238
133CSF1R0.33828522
134PRKAA10.33523750
135DMPK0.33169134
136PRKD10.32996167
137ROCK10.31808313
138STK30.30775933
139ERBB20.30584882
140ACVR1B0.30238987
141PLK30.29777968
142SRC0.28982633
143PIM20.28565752
144TESK20.22558654

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.61878916
2Nitrogen metabolism_Homo sapiens_hsa009103.34989120
3Sulfur metabolism_Homo sapiens_hsa009202.97995357
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.68590452
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67183993
6Fatty acid degradation_Homo sapiens_hsa000712.44757420
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40544010
8Tryptophan metabolism_Homo sapiens_hsa003802.20510871
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04199326
10Protein export_Homo sapiens_hsa030602.02505801
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93055357
12Propanoate metabolism_Homo sapiens_hsa006401.84972362
13Fatty acid metabolism_Homo sapiens_hsa012121.84267979
14Arginine biosynthesis_Homo sapiens_hsa002201.81366745
15Selenocompound metabolism_Homo sapiens_hsa004501.80579646
16Caffeine metabolism_Homo sapiens_hsa002321.78526411
17Histidine metabolism_Homo sapiens_hsa003401.78400202
18Butanoate metabolism_Homo sapiens_hsa006501.78256819
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77662789
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77603169
21Fat digestion and absorption_Homo sapiens_hsa049751.75453101
22Complement and coagulation cascades_Homo sapiens_hsa046101.65454102
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64051581
24Bile secretion_Homo sapiens_hsa049761.62244356
25Sphingolipid metabolism_Homo sapiens_hsa006001.60567084
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57344023
27PPAR signaling pathway_Homo sapiens_hsa033201.54874196
28Folate biosynthesis_Homo sapiens_hsa007901.52248197
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50880437
30Starch and sucrose metabolism_Homo sapiens_hsa005001.48166054
31Peroxisome_Homo sapiens_hsa041461.46489879
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39078754
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37655157
34Pyruvate metabolism_Homo sapiens_hsa006201.25914867
35Fatty acid elongation_Homo sapiens_hsa000621.19790654
36beta-Alanine metabolism_Homo sapiens_hsa004101.12635542
37Vitamin digestion and absorption_Homo sapiens_hsa049771.11412104
38Chemical carcinogenesis_Homo sapiens_hsa052041.08605483
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07945399
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04827269
41ABC transporters_Homo sapiens_hsa020101.04665177
42Protein digestion and absorption_Homo sapiens_hsa049741.04442615
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00058625
44N-Glycan biosynthesis_Homo sapiens_hsa005100.99402462
45Phagosome_Homo sapiens_hsa041450.98559951
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98397931
47Lysosome_Homo sapiens_hsa041420.96250170
48Carbon metabolism_Homo sapiens_hsa012000.95221216
49Phenylalanine metabolism_Homo sapiens_hsa003600.94518007
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93871852
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93692576
52Arginine and proline metabolism_Homo sapiens_hsa003300.92812930
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91368666
54Renin-angiotensin system_Homo sapiens_hsa046140.86828442
55Legionellosis_Homo sapiens_hsa051340.83596556
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.83008033
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81219218
58Mineral absorption_Homo sapiens_hsa049780.80300619
59Other glycan degradation_Homo sapiens_hsa005110.79194789
60Steroid biosynthesis_Homo sapiens_hsa001000.77483304
61Vitamin B6 metabolism_Homo sapiens_hsa007500.76048568
62Glycerolipid metabolism_Homo sapiens_hsa005610.76028936
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.75997020
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.75885153
65Arachidonic acid metabolism_Homo sapiens_hsa005900.74900276
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.74064266
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73089628
68Pancreatic secretion_Homo sapiens_hsa049720.71245765
69Biosynthesis of amino acids_Homo sapiens_hsa012300.70723702
70Thyroid hormone synthesis_Homo sapiens_hsa049180.70549330
71Insulin resistance_Homo sapiens_hsa049310.70485923
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69381162
73Tyrosine metabolism_Homo sapiens_hsa003500.68177382
74Collecting duct acid secretion_Homo sapiens_hsa049660.68062144
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67950330
76Prion diseases_Homo sapiens_hsa050200.67663511
77Glutathione metabolism_Homo sapiens_hsa004800.67063945
78Galactose metabolism_Homo sapiens_hsa000520.66730337
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66363556
80Vibrio cholerae infection_Homo sapiens_hsa051100.65860490
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65534619
82Staphylococcus aureus infection_Homo sapiens_hsa051500.63610450
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63447939
84Proteasome_Homo sapiens_hsa030500.61777662
85Retinol metabolism_Homo sapiens_hsa008300.60158020
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59166986
87Pertussis_Homo sapiens_hsa051330.58823381
88ECM-receptor interaction_Homo sapiens_hsa045120.56389028
89Bladder cancer_Homo sapiens_hsa052190.55489300
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.54347923
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54341448
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54339249
93Lysine degradation_Homo sapiens_hsa003100.53360601
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51673848
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51642669
96Ether lipid metabolism_Homo sapiens_hsa005650.49098568
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.49033463
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48513563
99Adherens junction_Homo sapiens_hsa045200.48002895
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47656050
101Pentose phosphate pathway_Homo sapiens_hsa000300.47101032
102Fatty acid biosynthesis_Homo sapiens_hsa000610.46777077
103Insulin secretion_Homo sapiens_hsa049110.43634386
104Shigellosis_Homo sapiens_hsa051310.42258666
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.41947235
106Salmonella infection_Homo sapiens_hsa051320.39470042
107Focal adhesion_Homo sapiens_hsa045100.39290622
108Hepatitis C_Homo sapiens_hsa051600.35851590
109Tuberculosis_Homo sapiens_hsa051520.35263043
110Glucagon signaling pathway_Homo sapiens_hsa049220.34672655
111AMPK signaling pathway_Homo sapiens_hsa041520.33673418
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33611801
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33281356
114Non-homologous end-joining_Homo sapiens_hsa034500.32852462
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32300933
116Linoleic acid metabolism_Homo sapiens_hsa005910.30902516
117Sulfur relay system_Homo sapiens_hsa041220.30096335
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.29628766
119Type II diabetes mellitus_Homo sapiens_hsa049300.27698376
120Fructose and mannose metabolism_Homo sapiens_hsa000510.27485299
121Metabolic pathways_Homo sapiens_hsa011000.27361359
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26097253
123Dorso-ventral axis formation_Homo sapiens_hsa043200.24079634
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23640348
125Amoebiasis_Homo sapiens_hsa051460.22971154

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