TM9SF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.26788851
2Golgi transport vesicle coating (GO:0048200)6.26788851
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.03371331
4protein retention in ER lumen (GO:0006621)4.81823063
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.97337678
6very-low-density lipoprotein particle assembly (GO:0034379)3.82176765
7plasma lipoprotein particle assembly (GO:0034377)3.75714163
8pinocytosis (GO:0006907)3.60470626
9protein-lipid complex assembly (GO:0065005)3.59478610
10proline biosynthetic process (GO:0006561)3.56903749
11apoptotic cell clearance (GO:0043277)3.55445282
12alpha-linolenic acid metabolic process (GO:0036109)3.49400414
13desmosome organization (GO:0002934)3.48011738
14regulation of extracellular matrix disassembly (GO:0010715)3.47493516
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.46711141
16vesicle coating (GO:0006901)3.40406446
17positive regulation of extracellular matrix organization (GO:1903055)3.37945752
18COPII vesicle coating (GO:0048208)3.36587774
19glucose 6-phosphate metabolic process (GO:0051156)3.35966442
20regulation of cholesterol biosynthetic process (GO:0045540)3.29531083
21cell-substrate junction assembly (GO:0007044)3.27786004
22cell-substrate adherens junction assembly (GO:0007045)3.27124313
23focal adhesion assembly (GO:0048041)3.27124313
24protein localization to endosome (GO:0036010)3.26037190
25adherens junction assembly (GO:0034333)3.22447667
26positive regulation of nuclease activity (GO:0032075)3.21906866
27exocrine pancreas development (GO:0031017)3.14349697
28regulation of fibrinolysis (GO:0051917)3.13397758
29hemidesmosome assembly (GO:0031581)3.11011628
30regulation of extracellular matrix organization (GO:1903053)3.10968515
31embryonic process involved in female pregnancy (GO:0060136)3.07678355
32alanine transport (GO:0032328)3.04296607
33protein carboxylation (GO:0018214)3.01659078
34peptidyl-glutamic acid carboxylation (GO:0017187)3.01659078
35endoplasmic reticulum unfolded protein response (GO:0030968)3.00890181
36peptidyl-proline hydroxylation (GO:0019511)2.96111474
37regulation of early endosome to late endosome transport (GO:2000641)2.92170364
38cellular response to unfolded protein (GO:0034620)2.90768065
394-hydroxyproline metabolic process (GO:0019471)2.89750180
40regulation of cholesterol homeostasis (GO:2000188)2.88407682
41epithelial cell-cell adhesion (GO:0090136)2.87220043
42keratan sulfate catabolic process (GO:0042340)2.85712416
43regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81571952
44ER-nucleus signaling pathway (GO:0006984)2.81488167
45regulation of nuclease activity (GO:0032069)2.80370425
46proline metabolic process (GO:0006560)2.79818975
47mannose metabolic process (GO:0006013)2.78495892
48cell adhesion mediated by integrin (GO:0033627)2.77825000
49sulfur amino acid catabolic process (GO:0000098)2.76377900
50L-alpha-amino acid transmembrane transport (GO:1902475)2.75617989
51protein hydroxylation (GO:0018126)2.73191348
52regulation of NFAT protein import into nucleus (GO:0051532)2.72887622
53regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72708638
54tooth mineralization (GO:0034505)2.72586648
55response to laminar fluid shear stress (GO:0034616)2.71443198
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71330770
57semaphorin-plexin signaling pathway (GO:0071526)2.69105155
58protein maturation by protein folding (GO:0022417)2.68884570
59dicarboxylic acid biosynthetic process (GO:0043650)2.68836742
60cell-cell junction maintenance (GO:0045217)2.67901698
61cellular response to topologically incorrect protein (GO:0035967)2.65975293
62pentose-phosphate shunt (GO:0006098)2.65817650
63branching involved in mammary gland duct morphogenesis (GO:0060444)2.65591644
64cellular response to epidermal growth factor stimulus (GO:0071364)2.65394245
65regulation of fatty acid beta-oxidation (GO:0031998)2.64814409
66regulation of plasminogen activation (GO:0010755)2.64342294
67cellular copper ion homeostasis (GO:0006878)2.63959180
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61923707
69activation of Rac GTPase activity (GO:0032863)2.60553352
70negative regulation of fatty acid transport (GO:2000192)2.59603663
71basement membrane organization (GO:0071711)2.59388172
72positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58536961
73low-density lipoprotein particle clearance (GO:0034383)2.55523218
74regulation of glucose import in response to insulin stimulus (GO:2001273)2.54118866
75heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.53343827
76regulation of apoptotic cell clearance (GO:2000425)2.52521523
77urea cycle (GO:0000050)2.52317671
78urea metabolic process (GO:0019627)2.52317671
79barbed-end actin filament capping (GO:0051016)2.51918810
80hypotonic response (GO:0006971)2.50752750
81glucose catabolic process (GO:0006007)2.50081113
82peptide catabolic process (GO:0043171)2.49805644
83tricarboxylic acid metabolic process (GO:0072350)2.48781716
84modulation by virus of host morphology or physiology (GO:0019048)2.48382421
85receptor catabolic process (GO:0032801)2.48048586
86negative regulation of fibrinolysis (GO:0051918)2.48024411
87positive regulation of fatty acid beta-oxidation (GO:0032000)2.47483525
88regulation of cholesterol esterification (GO:0010872)2.46980587
89regulation of cholesterol metabolic process (GO:0090181)2.45708505
90positive regulation of glycogen biosynthetic process (GO:0045725)2.44451192
91embryo implantation (GO:0007566)2.42943276
92glutamine family amino acid biosynthetic process (GO:0009084)2.41544523
93insulin-like growth factor receptor signaling pathway (GO:0048009)2.41443533
94intestinal cholesterol absorption (GO:0030299)2.41199410
95NADPH regeneration (GO:0006740)2.40573994
96cellular modified amino acid catabolic process (GO:0042219)2.38607859
97membrane protein ectodomain proteolysis (GO:0006509)2.38067190
98homocysteine metabolic process (GO:0050667)2.38037221
99epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37887596
100response to endoplasmic reticulum stress (GO:0034976)2.37432315
101triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.36954716
102cholesterol efflux (GO:0033344)2.36417098
103macroautophagy (GO:0016236)2.36208588
104regulation of superoxide anion generation (GO:0032928)2.36189708
105positive regulation of phagocytosis (GO:0050766)2.35625215
106apoptotic process involved in morphogenesis (GO:0060561)2.33429195
107positive regulation of hormone biosynthetic process (GO:0046886)2.32809699
108endodermal cell differentiation (GO:0035987)2.31836233
109plasma lipoprotein particle organization (GO:0071827)2.31731524
110protein-lipid complex subunit organization (GO:0071825)2.31601988
111platelet degranulation (GO:0002576)2.30560836
112cellular response to prostaglandin stimulus (GO:0071379)2.30357192
113stress fiber assembly (GO:0043149)2.30041402
114negative regulation of cell size (GO:0045792)2.30041189
115low-density lipoprotein particle remodeling (GO:0034374)2.29728772
116oxaloacetate metabolic process (GO:0006107)2.27412467
117hyaluronan metabolic process (GO:0030212)2.27194833
118sulfur compound catabolic process (GO:0044273)2.26283971
119phospholipid homeostasis (GO:0055091)2.25529772
120regulation of cholesterol storage (GO:0010885)2.25276142
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.24561285
122L-phenylalanine catabolic process (GO:0006559)2.24561285
123reverse cholesterol transport (GO:0043691)2.23995896
124neuron projection extension involved in neuron projection guidance (GO:1902284)2.22920395
125axon extension involved in axon guidance (GO:0048846)2.22920395
126negative regulation of lipid transport (GO:0032369)2.22788158
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.20084316
128complement activation, alternative pathway (GO:0006957)2.20008404
129modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.19916840
130positive regulation by organism of defense response of other organism involved in symbiotic interact2.19916840
131modulation by symbiont of host immune response (GO:0052553)2.19916840
132positive regulation by symbiont of host defense response (GO:0052509)2.19916840
133modulation by symbiont of host defense response (GO:0052031)2.19916840
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.19916840
135skin morphogenesis (GO:0043589)2.19649674
136polarized epithelial cell differentiation (GO:0030859)2.19476752
137L-phenylalanine metabolic process (GO:0006558)2.19023724
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.19023724
139heparan sulfate proteoglycan metabolic process (GO:0030201)2.18594230
140glyoxylate metabolic process (GO:0046487)2.18097079
141regulation of protein activation cascade (GO:2000257)2.17151924
1422-oxoglutarate metabolic process (GO:0006103)2.13992467
143positive regulation of p38MAPK cascade (GO:1900745)2.12340462
144linoleic acid metabolic process (GO:0043651)2.12038720
145plasma lipoprotein particle clearance (GO:0034381)2.11741096
146chondroitin sulfate catabolic process (GO:0030207)2.11038695
147pyrimidine nucleobase catabolic process (GO:0006208)2.10765521
148regulation of complement activation (GO:0030449)2.09719199
149peptidyl-asparagine modification (GO:0018196)2.09342891
150protein N-linked glycosylation via asparagine (GO:0018279)2.08522637
151lipoprotein metabolic process (GO:0042157)2.08114521
152positive regulation of triglyceride biosynthetic process (GO:0010867)2.07217389
153response to unfolded protein (GO:0006986)2.06885290
154positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.06859931
155valine metabolic process (GO:0006573)2.06526598
156glial cell migration (GO:0008347)2.04664206
157lysine catabolic process (GO:0006554)2.03932226
158lysine metabolic process (GO:0006553)2.03932226
159maternal placenta development (GO:0001893)2.03699765
160positive regulation of glycogen metabolic process (GO:0070875)2.03184843
161positive regulation of fatty acid oxidation (GO:0046321)2.03033778
162nitrogen cycle metabolic process (GO:0071941)2.02305877
163cytoskeletal anchoring at plasma membrane (GO:0007016)2.01842212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.07671656
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.99704798
3ZNF263_19887448_ChIP-Seq_K562_Human2.99210916
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.98203983
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72030959
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.65218946
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61585387
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55020003
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.48316943
10CLOCK_20551151_ChIP-Seq_293T_Human2.39284351
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.36754011
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.22060735
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.17284259
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.12404949
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.11288311
16MYC_22102868_ChIP-Seq_BL_Human2.02191992
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.99452994
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94912109
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.90097050
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81466220
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80293354
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79460905
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78799708
24LXR_22292898_ChIP-Seq_THP-1_Human1.71943506
25* TCF7_22412390_ChIP-Seq_EML_Mouse1.70785694
26VDR_21846776_ChIP-Seq_THP-1_Human1.69946016
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67684230
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.66485738
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64453832
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61357724
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60452554
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56701105
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56205672
34TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.54652161
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54521576
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53124694
37* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52065869
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49923080
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47111359
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.45871800
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44998641
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44021347
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43203550
44KDM2B_26808549_Chip-Seq_K562_Human1.42986114
45KDM2B_26808549_Chip-Seq_DND41_Human1.41750097
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40975568
47ATF3_27146783_Chip-Seq_COLON_Human1.39496158
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38770452
49RACK7_27058665_Chip-Seq_MCF-7_Human1.33724905
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33124569
51* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32840787
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.31604256
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31105585
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30025272
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28908214
56AR_21909140_ChIP-Seq_LNCAP_Human1.28415447
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27174564
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25996644
59* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24241937
60TP53_22127205_ChIP-Seq_IMR90_Human1.22301175
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22102283
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21364831
63* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20769593
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20550171
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.20480296
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20242536
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20187008
68* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19991843
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19628405
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18184904
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17916430
72* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17523943
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17381620
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.17360055
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16952583
76SOX2_20726797_ChIP-Seq_SW620_Human1.15922569
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15857483
78AHR_22903824_ChIP-Seq_MCF-7_Human1.14976842
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14418799
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14377424
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.14361161
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14047809
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13857763
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12555881
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11802806
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11788850
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11393642
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11249121
89CJUN_26792858_Chip-Seq_BT549_Human1.10455270
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10148264
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09959298
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09734984
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09704769
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09456591
95* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09248302
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08735275
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08498100
98DROSHA_22980978_ChIP-Seq_HELA_Human1.08389412
99NCOR1_26117541_ChIP-Seq_K562_Human1.07371138
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06276219
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05789878
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05625462
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05393925
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05286303
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04926306
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04197108
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.03681724
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03070098
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02769666
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.02299745
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01626836
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01191937
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.00959852
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00457532
115* EP300_21415370_ChIP-Seq_HL-1_Mouse1.00260154
116SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00231813
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00231590
118SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00184341
119RXR_22108803_ChIP-Seq_LS180_Human0.99670735
120STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99508509
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99298485
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99120120
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99120120
124GATA6_25053715_ChIP-Seq_YYC3_Human0.98442069
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98222990
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98138423
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97652966
128* SMC4_20622854_ChIP-Seq_HELA_Human0.96680400
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96365729
130CREB1_26743006_Chip-Seq_LNCaP_Human0.95609904
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94763582
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.92961646
133AR_19668381_ChIP-Seq_PC3_Human0.92903041
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92882452
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.92573867
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92425879
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91614809
138SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91466887
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90553599
140* TBX20_22080862_ChIP-Seq_HEART_Mouse0.90049714
141* TBX20_22328084_ChIP-Seq_HEART_Mouse0.90049714
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89582555
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89526395
144EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89526395
145SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89076035
146TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88877360
147CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88595866
148GATA2_21666600_ChIP-Seq_HMVEC_Human0.88498438
149TP53_16413492_ChIP-PET_HCT116_Human0.88395408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.63494428
2MP0002139_abnormal_hepatobiliary_system3.38064147
3MP0003705_abnormal_hypodermis_morpholog3.16870111
4MP0009780_abnormal_chondrocyte_physiolo3.08393969
5MP0005365_abnormal_bile_salt3.06567630
6MP0005451_abnormal_body_composition2.93267411
7MP0003172_abnormal_lysosome_physiology2.81349214
8MP0005058_abnormal_lysosome_morphology2.80178343
9MP0004272_abnormal_basement_membrane2.63278597
10MP0005409_darkened_coat_color2.39848777
11MP0003183_abnormal_peptide_metabolism2.39143338
12MP0005083_abnormal_biliary_tract2.37585696
13MP0004858_abnormal_nervous_system2.34493060
14MP0003283_abnormal_digestive_organ2.22134406
15MP0009840_abnormal_foam_cell2.20294517
16MP0008260_abnormal_autophagy2.18920433
17MP0010329_abnormal_lipoprotein_level1.93895610
18MP0005503_abnormal_tendon_morphology1.92980411
19MP0005085_abnormal_gallbladder_physiolo1.91151449
20MP0009384_cardiac_valve_regurgitation1.86165505
21MP0005275_abnormal_skin_tensile1.84910412
22MP0000569_abnormal_digit_pigmentation1.77754504
23MP0004233_abnormal_muscle_weight1.75771669
24MP0002909_abnormal_adrenal_gland1.74732997
25MP0000566_synostosis1.70206445
26MP0005360_urolithiasis1.69317640
27MP0003300_gastrointestinal_ulcer1.67190610
28MP0005076_abnormal_cell_differentiation1.67060176
29MP0003566_abnormal_cell_adhesion1.65184111
30MP0003252_abnormal_bile_duct1.63363285
31MP0003453_abnormal_keratinocyte_physiol1.59984764
32MP0000858_altered_metastatic_potential1.56374900
33MP0000678_abnormal_parathyroid_gland1.54866318
34MP0002837_dystrophic_cardiac_calcinosis1.54362600
35MP0002060_abnormal_skin_morphology1.50366684
36MP0003690_abnormal_glial_cell1.49525922
37MP0001666_abnormal_nutrient_absorption1.49187366
38MP0002896_abnormal_bone_mineralization1.48015789
39MP0010352_gastrointestinal_tract_polyps1.47976279
40MP0003941_abnormal_skin_development1.47841296
41MP0010368_abnormal_lymphatic_system1.47305842
42MP0001849_ear_inflammation1.46116938
43MP0002796_impaired_skin_barrier1.45959600
44MP0003191_abnormal_cellular_cholesterol1.45532200
45MP0000013_abnormal_adipose_tissue1.45045506
46MP0005220_abnormal_exocrine_pancreas1.44639635
47MP0003195_calcinosis1.43044457
48MP0003279_aneurysm1.40387708
49MP0010386_abnormal_urinary_bladder1.37398217
50MP0002295_abnormal_pulmonary_circulatio1.37226456
51MP0003122_maternal_imprinting1.36385634
52MP0000604_amyloidosis1.34541238
53MP0005023_abnormal_wound_healing1.32529953
54MP0004859_abnormal_synaptic_plasticity1.32321591
55MP0004185_abnormal_adipocyte_glucose1.31217680
56MP0002089_abnormal_postnatal_growth/wei1.29288779
57MP0003045_fibrosis1.25584371
58MP0008875_abnormal_xenobiotic_pharmacok1.23665623
59MP0005501_abnormal_skin_physiology1.21723485
60MP0003436_decreased_susceptibility_to1.21238118
61MP0002877_abnormal_melanocyte_morpholog1.19661374
62MP0001944_abnormal_pancreas_morphology1.19290518
63MP0005408_hypopigmentation1.19040909
64MP0008961_abnormal_basal_metabolism1.17114650
65MP0004264_abnormal_extraembryonic_tissu1.13390435
66MP0002118_abnormal_lipid_homeostasis1.12546393
67MP0000537_abnormal_urethra_morphology1.11595285
68MP0006054_spinal_hemorrhage1.10235980
69MP0000767_abnormal_smooth_muscle1.09635239
70MP0000534_abnormal_ureter_morphology1.09615110
71MP0003075_altered_response_to1.09528680
72MP0002078_abnormal_glucose_homeostasis1.07244020
73MP0001756_abnormal_urination1.06319525
74MP0001730_embryonic_growth_arrest1.05677666
75MP0000609_abnormal_liver_physiology1.04505341
76MP0005621_abnormal_cell_physiology1.03233035
77MP0003329_amyloid_beta_deposits1.03177500
78MP0005257_abnormal_intraocular_pressure1.02678102
79MP0005508_abnormal_skeleton_morphology1.02329390
80MP0000003_abnormal_adipose_tissue1.02149321
81MP0005332_abnormal_amino_acid1.02032772
82MP0002168_other_aberrant_phenotype1.00696564
83MP0001299_abnormal_eye_distance/1.00197036
84MP0003942_abnormal_urinary_system0.99261777
85MP0002090_abnormal_vision0.98933718
86MP0005319_abnormal_enzyme/_coenzyme0.96624417
87MP0003303_peritoneal_inflammation0.94693079
88MP0002086_abnormal_extraembryonic_tissu0.94507771
89MP0000762_abnormal_tongue_morphology0.92745198
90MP0002693_abnormal_pancreas_physiology0.92523839
91MP0001958_emphysema0.92103541
92MP0005623_abnormal_meninges_morphology0.89068437
93MP0001216_abnormal_epidermal_layer0.88323591
94MP0002396_abnormal_hematopoietic_system0.88123010
95MP0000579_abnormal_nail_morphology0.87234095
96MP0005464_abnormal_platelet_physiology0.87115656
97MP0009672_abnormal_birth_weight0.86803057
98MP0000751_myopathy0.86700497
99MP0005375_adipose_tissue_phenotype0.85957432
100MP0010630_abnormal_cardiac_muscle0.85579643
101MP0002108_abnormal_muscle_morphology0.84670499
102MP0004947_skin_inflammation0.84563996
103MP0000467_abnormal_esophagus_morphology0.84334435
104MP0001533_abnormal_skeleton_physiology0.83112449
105MP0000733_abnormal_muscle_development0.82773110
106MP0005670_abnormal_white_adipose0.81699950
107MP0010030_abnormal_orbit_morphology0.81302730
108MP0000163_abnormal_cartilage_morphology0.81245029
109MP0009643_abnormal_urine_homeostasis0.79985400
110MP0003984_embryonic_growth_retardation0.79890214
111MP0005666_abnormal_adipose_tissue0.79620038
112MP0005448_abnormal_energy_balance0.78575052
113MP0000639_abnormal_adrenal_gland0.78068955
114MP0002998_abnormal_bone_remodeling0.77493128
115MP0001915_intracranial_hemorrhage0.77187820
116MP0004130_abnormal_muscle_cell0.77014591
117MP0010234_abnormal_vibrissa_follicle0.76373507
118MP0002115_abnormal_skeleton_extremities0.75401011
119MP0003091_abnormal_cell_migration0.74825060
120MP0009053_abnormal_anal_canal0.72926281
121MP0003953_abnormal_hormone_level0.72799405
122MP0002088_abnormal_embryonic_growth/wei0.72592853
123MP0005164_abnormal_response_to0.72385545
124MP0005390_skeleton_phenotype0.72295179
125MP0005384_cellular_phenotype0.72197359
126MP0002080_prenatal_lethality0.71665695
127MP0003868_abnormal_feces_composition0.71229131
128MP0002098_abnormal_vibrissa_morphology0.71139727
129MP0004782_abnormal_surfactant_physiolog0.71134503
130MP0002928_abnormal_bile_duct0.71026629
131MP0001672_abnormal_embryogenesis/_devel0.70681708
132MP0005380_embryogenesis_phenotype0.70681708
133MP0001614_abnormal_blood_vessel0.70510495
134MP0009931_abnormal_skin_appearance0.69821906
135MP0002269_muscular_atrophy0.69767699
136MP0000598_abnormal_liver_morphology0.69756322
137MP0005248_abnormal_Harderian_gland0.68745205
138MP0001348_abnormal_lacrimal_gland0.68514849
139MP0003656_abnormal_erythrocyte_physiolo0.67161222
140MP0003634_abnormal_glial_cell0.67145542
141MP0002925_abnormal_cardiovascular_devel0.66616061
142MP0003950_abnormal_plasma_membrane0.66331425
143MP0003115_abnormal_respiratory_system0.64558646
144MP0000627_abnormal_mammary_gland0.64358990
145MP0000462_abnormal_digestive_system0.64330185
146MP0009115_abnormal_fat_cell0.63427256
147MP0002135_abnormal_kidney_morphology0.62098990
148MP0003123_paternal_imprinting0.60450046
149MP0003385_abnormal_body_wall0.59258205

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)4.78822313
2Mucopolysacchariduria (HP:0008155)3.78825779
3Urinary glycosaminoglycan excretion (HP:0003541)3.78825779
4Protrusio acetabuli (HP:0003179)3.56508042
5Abnormality of mucopolysaccharide metabolism (HP:0011020)3.51113565
6Abnormality of polysaccharide metabolism (HP:0011012)3.51113565
7Abnormality of glycosaminoglycan metabolism (HP:0004371)3.51113565
8Dysostosis multiplex (HP:0000943)3.15753586
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.15633195
10Turricephaly (HP:0000262)2.95299237
11Shallow orbits (HP:0000586)2.88410429
12Cerebral aneurysm (HP:0004944)2.86099187
13Hand muscle atrophy (HP:0009130)2.84051452
14Thin bony cortex (HP:0002753)2.82355291
15Asymmetry of the thorax (HP:0001555)2.79406316
16Abnormality of carpal bone ossification (HP:0006257)2.77478476
17Deep venous thrombosis (HP:0002625)2.68373400
18Premature rupture of membranes (HP:0001788)2.66052217
19Vacuolated lymphocytes (HP:0001922)2.62485791
20Broad metatarsal (HP:0001783)2.61260702
21Hyperacusis (HP:0010780)2.57383446
22Hypoglycemic coma (HP:0001325)2.56713806
23Upper limb amyotrophy (HP:0009129)2.54637769
24Distal upper limb amyotrophy (HP:0007149)2.54637769
25Hemorrhage of the eye (HP:0011885)2.52493190
26Symptomatic seizures (HP:0011145)2.46874374
27Abnormality of the intrinsic pathway (HP:0010989)2.46221040
28Abnormal ossification of hand bones (HP:0005921)2.45716170
29Hyperinsulinemic hypoglycemia (HP:0000825)2.39626680
30Hypoglycemic seizures (HP:0002173)2.36820879
31Ketoacidosis (HP:0001993)2.34243818
32Late onset (HP:0003584)2.34130280
33Increased cerebral lipofuscin (HP:0011813)2.32093176
34Fragile skin (HP:0001030)2.32023796
35Aneurysm (HP:0002617)2.31409855
36Atrophic scars (HP:0001075)2.30777322
37Bladder diverticulum (HP:0000015)2.27192835
38Ulnar bowing (HP:0003031)2.26001840
39Hypercholesterolemia (HP:0003124)2.25241319
40Peritonitis (HP:0002586)2.24353705
41Abnormality of the common coagulation pathway (HP:0010990)2.22475931
42Abnormality of the Achilles tendon (HP:0005109)2.22236085
43Right ventricular cardiomyopathy (HP:0011663)2.19416928
44Abnormality of dentin (HP:0010299)2.16733137
45Broad palm (HP:0001169)2.13089123
46Disproportionate tall stature (HP:0001519)2.12978492
47Wormian bones (HP:0002645)2.12873081
48Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.10792492
49Vertebral hypoplasia (HP:0008417)2.10792492
50Joint hemorrhage (HP:0005261)2.10564222
51Protuberant abdomen (HP:0001538)2.10115935
52Small epiphyses (HP:0010585)2.09977770
53Complement deficiency (HP:0004431)2.09127068
54Beaking of vertebral bodies (HP:0004568)2.07924742
55Menorrhagia (HP:0000132)2.07646754
56Neurofibrillary tangles (HP:0002185)2.05044745
57Long toe (HP:0010511)2.03899403
58Advanced eruption of teeth (HP:0006288)2.03881876
59Achilles tendon contracture (HP:0001771)2.03745039
60Skin nodule (HP:0200036)2.03476238
61Lymphangioma (HP:0100764)2.03337525
62Cupped ribs (HP:0000887)2.01636800
63Systemic lupus erythematosus (HP:0002725)2.00771395
64Bronchomalacia (HP:0002780)2.00691848
65Ankyloglossia (HP:0010296)2.00244428
66Hypoplasia of the odontoid process (HP:0003311)1.99929677
67Coxa vara (HP:0002812)1.99635979
68Striae distensae (HP:0001065)1.98738592
69Vascular tortuosity (HP:0004948)1.98002028
70Prolonged partial thromboplastin time (HP:0003645)1.96611498
71Neonatal short-limb short stature (HP:0008921)1.95694094
72Abnormal hand bone ossification (HP:0010660)1.95449842
73Cerebral inclusion bodies (HP:0100314)1.95262261
74Hepatoblastoma (HP:0002884)1.93443752
75Abnormal tarsal ossification (HP:0008369)1.92376199
76Aortic dissection (HP:0002647)1.91873704
77Back pain (HP:0003418)1.91822608
78Arterial tortuosity (HP:0005116)1.90402342
79J-shaped sella turcica (HP:0002680)1.90121430
80Ankle contracture (HP:0006466)1.89184012
81Ketosis (HP:0001946)1.88868775
82Mitral stenosis (HP:0001718)1.88065501
83Generalized aminoaciduria (HP:0002909)1.87402804
84Biconcave vertebral bodies (HP:0004586)1.87230008
85Neonatal death (HP:0003811)1.87079048
86Broad face (HP:0000283)1.85522555
87Insomnia (HP:0100785)1.85488533
88Xanthomatosis (HP:0000991)1.84359592
89Abnormal delivery (HP:0001787)1.83918694
90Gout (HP:0001997)1.83717452
91Aortic aneurysm (HP:0004942)1.83710299
92Focal segmental glomerulosclerosis (HP:0000097)1.83427337
93Flared iliac wings (HP:0002869)1.83411969
94Abnormal gallbladder physiology (HP:0012438)1.83265275
95Cholecystitis (HP:0001082)1.83265275
96Ovoid vertebral bodies (HP:0003300)1.83166435
97Increased connective tissue (HP:0009025)1.82356692
98Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81441809
99Dislocated radial head (HP:0003083)1.80151326
100Enlarged penis (HP:0000040)1.80000527
101Abnormality of oral frenula (HP:0000190)1.79288251
102Mitral regurgitation (HP:0001653)1.79006738
103Abnormality of endocrine pancreas physiology (HP:0012093)1.76595251
104Abnormality of the pancreatic islet cells (HP:0006476)1.76595251
105Distal lower limb amyotrophy (HP:0008944)1.76315296
106Abnormality of calcium-phosphate metabolism (HP:0100530)1.74386927
107Abnormality of the odontoid process (HP:0003310)1.74370102
108Dilatation of the ascending aorta (HP:0005111)1.74242996
109Hyperglycemia (HP:0003074)1.72994920
110Short nail (HP:0001799)1.72455452
111Soft skin (HP:0000977)1.71150906
112Spinal rigidity (HP:0003306)1.70835929
113Renal duplication (HP:0000075)1.70698730
114Blue sclerae (HP:0000592)1.70498671
115Pterygium (HP:0001059)1.69953193
116Increased neuronal autofluorescent lipopigment (HP:0002074)1.69143972
117Abnormal foot bone ossification (HP:0010675)1.68854470
118Abnormality of the lumbar spine (HP:0100712)1.68217051
119Cardiovascular calcification (HP:0011915)1.68140603
120Myocardial infarction (HP:0001658)1.67448292
121Abnormality of the acetabulum (HP:0003170)1.66508113
122Vascular calcification (HP:0004934)1.66244336
123Arnold-Chiari malformation (HP:0002308)1.65784406
124Glomerulonephritis (HP:0000099)1.65628416
125Growth hormone excess (HP:0000845)1.65331262
126Joint laxity (HP:0001388)1.65264263
127Femoral bowing (HP:0002980)1.65243138
128Natal tooth (HP:0000695)1.63487872
129Amyloidosis (HP:0011034)1.63363734
130Subacute progressive viral hepatitis (HP:0006572)1.63176203
131Conjugated hyperbilirubinemia (HP:0002908)1.62607702
132Gingival overgrowth (HP:0000212)1.62517697
133Premature skin wrinkling (HP:0100678)1.62342533
134Abnormality of the radial head (HP:0003995)1.62272853
135Epidermoid cyst (HP:0200040)1.61631763
136Asymmetric septal hypertrophy (HP:0001670)1.61505152
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.61272483
138Osteolytic defects of the hand bones (HP:0009699)1.61272483
139Breech presentation (HP:0001623)1.61204442
140Abnormality of the distal phalanx of the thumb (HP:0009617)1.60928596
141Macroorchidism (HP:0000053)1.60834541
142Mitral valve prolapse (HP:0001634)1.60621590
143Tibial bowing (HP:0002982)1.59546729
144Disproportionate short-trunk short stature (HP:0003521)1.58941923
145Hypercortisolism (HP:0001578)1.58449076
146Joint stiffness (HP:0001387)1.58230554
147Abnormality of glycolipid metabolism (HP:0010969)1.58217941
148Abnormality of liposaccharide metabolism (HP:0010968)1.58217941
149Abnormality of glycosphingolipid metabolism (HP:0004343)1.58217941
150Osteopenia (HP:0000938)1.57770125
151Flat acetabular roof (HP:0003180)1.57186934
152Hyperextensible skin (HP:0000974)1.56367362
153Vertebral compression fractures (HP:0002953)1.55639193
154Abdominal distention (HP:0003270)1.55621445
155Deviation of the hallux (HP:0010051)1.55526154
156Abnormality of complement system (HP:0005339)1.54883077
157Deformed sella turcica (HP:0002681)1.54825273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.76091396
2TRIB33.71897478
3SMG13.20288552
4SIK12.94398784
5PRKD32.85910719
6RIPK12.80908915
7PDGFRA2.50188522
8PRPF4B2.29924044
9DDR22.28159852
10INSRR2.15627444
11IRAK32.07896357
12PKN21.98337722
13CAMK1D1.90792852
14LMTK21.88435934
15MST1R1.86638228
16PTK61.82851558
17AKT31.80097186
18PTK21.56846154
19FRK1.53498070
20FGFR41.52705531
21CAMK1G1.52042321
22DAPK21.49297073
23TGFBR21.38222075
24SIK21.38190176
25MAP3K101.34866767
26CAMKK11.34683118
27MAP3K91.30993422
28CCNB11.28450016
29NTRK31.26794348
30MET1.24826937
31FER1.23031492
32MAP3K31.22765584
33SGK31.22617288
34BCKDK1.18443873
35EPHA31.15692721
36TTN1.15365791
37SGK21.14954196
38LATS21.10715520
39CDK191.09499070
40SCYL21.08529200
41MAPK151.07920882
42CDK121.07591338
43MAP2K31.06347752
44BMX1.06073382
45NTRK11.05099983
46EPHB11.04776801
47PAK31.00767651
48EEF2K0.93967924
49MTOR0.93878358
50RPS6KA20.93187038
51MARK10.93043459
52CAMKK20.92690842
53PDPK10.92024282
54PASK0.91174688
55LATS10.90918466
56ARAF0.90270702
57PAK40.90182555
58SIK30.89074606
59EPHB20.87400902
60MAP3K20.87132398
61MAP2K40.86752108
62TAOK20.85460559
63ERBB20.83285922
64NEK90.82064156
65JAK10.81090914
66MINK10.79472393
67PRKCH0.78675397
68MOS0.78532889
69DAPK10.77118602
70CDC42BPA0.76806862
71PAK60.75170368
72MARK20.75156801
73PRKD20.75057097
74CDK70.74400411
75NME20.72280418
76TYRO30.72149553
77ALK0.71700230
78FGFR30.70559338
79MAPK110.70442669
80EIF2AK10.70400072
81PAK20.67922697
82DMPK0.65898248
83MAP3K130.65715035
84CDK60.64886181
85FGR0.64593888
86FGFR10.63966866
87ERBB40.63788911
88MAP2K10.63744763
89BRAF0.63539324
90TAOK10.63276490
91BRD40.62313055
92TESK20.61386050
93MAP3K40.60339402
94TYK20.60015013
95RPS6KB20.57916439
96RET0.57813571
97CDK90.57375717
98ZAP700.56708868
99LRRK20.55977534
100WNK10.55139391
101MAP3K80.54672836
102PDGFRB0.54237310
103JAK20.54024630
104TAOK30.53934575
105SGK4940.53202880
106SGK2230.53202880
107ICK0.52258181
108CHUK0.50860034
109DYRK1B0.49660557
110CAMK40.49211998
111HIPK20.48815720
112SRC0.48427551
113ERBB30.45447015
114MAPKAPK30.45097223
115MAP3K60.44098702
116TESK10.44083998
117IGF1R0.43417018
118ROCK10.43257686
119MELK0.43179901
120STK380.42728620
121YES10.42611889
122EPHA20.42437375
123MAP3K10.42143909
124PDK10.42098413
125RIPK40.41605386
126NEK10.41479944
127KSR20.40630382
128PIK3CG0.40374014
129CDK40.39713563
130PIM20.39460551
131WNK30.38888478
132MATK0.38782291
133PRKAA10.37517890
134CDK50.37259675
135KSR10.37176296
136PRKACG0.36224262
137NTRK20.36119775
138CDK80.35118794
139PRKG20.34807154
140MAPKAPK20.34578059
141TBK10.34470316
142MAP3K70.34121912
143CSF1R0.31425416
144MAP3K140.31146480
145BRSK10.30768501
146ROCK20.28961998

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.50430682
2Nitrogen metabolism_Homo sapiens_hsa009102.34363525
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.16105915
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07612610
5Lysosome_Homo sapiens_hsa041421.73104551
6Fatty acid degradation_Homo sapiens_hsa000711.70302998
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68784352
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64808714
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.64074073
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60821162
11Non-small cell lung cancer_Homo sapiens_hsa052231.54235178
12Arginine biosynthesis_Homo sapiens_hsa002201.53672586
13Thyroid cancer_Homo sapiens_hsa052161.49874899
14Fatty acid metabolism_Homo sapiens_hsa012121.47094090
15Tryptophan metabolism_Homo sapiens_hsa003801.44508942
16Complement and coagulation cascades_Homo sapiens_hsa046101.42895021
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42812076
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41687502
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38058436
20Pentose phosphate pathway_Homo sapiens_hsa000301.37501715
21Type II diabetes mellitus_Homo sapiens_hsa049301.36953907
22Pancreatic cancer_Homo sapiens_hsa052121.35637008
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33806558
24Galactose metabolism_Homo sapiens_hsa000521.31007289
25Other glycan degradation_Homo sapiens_hsa005111.30791114
26PPAR signaling pathway_Homo sapiens_hsa033201.28972487
27Acute myeloid leukemia_Homo sapiens_hsa052211.26465465
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.25730540
29Small cell lung cancer_Homo sapiens_hsa052221.24618408
30Insulin secretion_Homo sapiens_hsa049111.23613238
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20767366
32Staphylococcus aureus infection_Homo sapiens_hsa051501.20634799
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19813521
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17501903
35Notch signaling pathway_Homo sapiens_hsa043301.16944663
36N-Glycan biosynthesis_Homo sapiens_hsa005101.16329024
37Starch and sucrose metabolism_Homo sapiens_hsa005001.15094384
38VEGF signaling pathway_Homo sapiens_hsa043701.14162772
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13666589
40Bile secretion_Homo sapiens_hsa049761.13190311
41Butanoate metabolism_Homo sapiens_hsa006501.10325499
42Renal cell carcinoma_Homo sapiens_hsa052111.09667946
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08881704
44Prion diseases_Homo sapiens_hsa050201.08641057
45Lysine degradation_Homo sapiens_hsa003101.07521429
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03362635
47ErbB signaling pathway_Homo sapiens_hsa040120.98819752
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96281793
49Vibrio cholerae infection_Homo sapiens_hsa051100.95087231
50Insulin resistance_Homo sapiens_hsa049310.94638534
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.93871270
52Synaptic vesicle cycle_Homo sapiens_hsa047210.92742160
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92073250
54Focal adhesion_Homo sapiens_hsa045100.90827489
55MicroRNAs in cancer_Homo sapiens_hsa052060.90408933
56Prostate cancer_Homo sapiens_hsa052150.88353549
57HIF-1 signaling pathway_Homo sapiens_hsa040660.85724779
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.85575963
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84414507
60Bladder cancer_Homo sapiens_hsa052190.83585080
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83521553
62Sulfur metabolism_Homo sapiens_hsa009200.82372317
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82088514
64Hepatitis C_Homo sapiens_hsa051600.81424639
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81334368
66Phenylalanine metabolism_Homo sapiens_hsa003600.81294904
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78859431
68Selenocompound metabolism_Homo sapiens_hsa004500.78808755
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78427710
70Proteoglycans in cancer_Homo sapiens_hsa052050.77922395
71ECM-receptor interaction_Homo sapiens_hsa045120.77318465
72beta-Alanine metabolism_Homo sapiens_hsa004100.77274481
73Fat digestion and absorption_Homo sapiens_hsa049750.77057081
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76665032
75Amoebiasis_Homo sapiens_hsa051460.76496932
76Choline metabolism in cancer_Homo sapiens_hsa052310.76030299
77Protein digestion and absorption_Homo sapiens_hsa049740.73955863
78Glucagon signaling pathway_Homo sapiens_hsa049220.73866862
79Fructose and mannose metabolism_Homo sapiens_hsa000510.72781658
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72722063
81Endocytosis_Homo sapiens_hsa041440.72693578
82Dilated cardiomyopathy_Homo sapiens_hsa054140.71992191
83GnRH signaling pathway_Homo sapiens_hsa049120.71666662
84Adherens junction_Homo sapiens_hsa045200.70685732
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68950126
86Vitamin digestion and absorption_Homo sapiens_hsa049770.68926644
87Caffeine metabolism_Homo sapiens_hsa002320.68732494
88Inositol phosphate metabolism_Homo sapiens_hsa005620.66330524
89Insulin signaling pathway_Homo sapiens_hsa049100.65721915
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65624106
91Hepatitis B_Homo sapiens_hsa051610.65543054
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65184092
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64615566
94Cocaine addiction_Homo sapiens_hsa050300.64039106
95Vitamin B6 metabolism_Homo sapiens_hsa007500.63906344
96Biosynthesis of amino acids_Homo sapiens_hsa012300.62654443
97Fatty acid biosynthesis_Homo sapiens_hsa000610.61849936
98ABC transporters_Homo sapiens_hsa020100.61401353
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.61168811
100Shigellosis_Homo sapiens_hsa051310.60431823
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60280713
102Thyroid hormone synthesis_Homo sapiens_hsa049180.60153523
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.59007453
104Renin-angiotensin system_Homo sapiens_hsa046140.58571348
105Colorectal cancer_Homo sapiens_hsa052100.58092826
106Phagosome_Homo sapiens_hsa041450.57176554
107Sphingolipid metabolism_Homo sapiens_hsa006000.57042642
108Carbon metabolism_Homo sapiens_hsa012000.56957775
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.56873138
110Chronic myeloid leukemia_Homo sapiens_hsa052200.54587197
111AMPK signaling pathway_Homo sapiens_hsa041520.53197787
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52804882
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52242362
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52168641
115Toxoplasmosis_Homo sapiens_hsa051450.52124493
116Pertussis_Homo sapiens_hsa051330.51259107
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.50809527
118Estrogen signaling pathway_Homo sapiens_hsa049150.49814473
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49156194
120Legionellosis_Homo sapiens_hsa051340.48647572
121Apoptosis_Homo sapiens_hsa042100.48014131
122Glioma_Homo sapiens_hsa052140.47522285
123Salmonella infection_Homo sapiens_hsa051320.47300695
124Propanoate metabolism_Homo sapiens_hsa006400.46708466
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46332929
126mTOR signaling pathway_Homo sapiens_hsa041500.45219564
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44915451
128Pancreatic secretion_Homo sapiens_hsa049720.44875254
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42837038
130Histidine metabolism_Homo sapiens_hsa003400.42705741
131Endometrial cancer_Homo sapiens_hsa052130.41898024
132Peroxisome_Homo sapiens_hsa041460.38673408
133GABAergic synapse_Homo sapiens_hsa047270.38309457
134Prolactin signaling pathway_Homo sapiens_hsa049170.38084568
135Chemical carcinogenesis_Homo sapiens_hsa052040.37906332
136Mineral absorption_Homo sapiens_hsa049780.37788878
137Steroid biosynthesis_Homo sapiens_hsa001000.36605461
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.36116807
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35798147
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35792678

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