TMA16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.82110139
2maturation of SSU-rRNA (GO:0030490)5.07838203
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.98849174
4ATP synthesis coupled proton transport (GO:0015986)4.98849174
5chaperone-mediated protein transport (GO:0072321)4.93473349
6ribosomal small subunit assembly (GO:0000028)4.91153513
7viral transcription (GO:0019083)4.85780698
8translational termination (GO:0006415)4.80220432
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.77195877
10ribosomal small subunit biogenesis (GO:0042274)4.69764335
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47611726
12cotranslational protein targeting to membrane (GO:0006613)4.42978756
13protein targeting to ER (GO:0045047)4.37961623
14establishment of integrated proviral latency (GO:0075713)4.30363225
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.21517604
16response to peptidoglycan (GO:0032494)4.16425379
17translational elongation (GO:0006414)4.15883038
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.14988500
19protein localization to endoplasmic reticulum (GO:0070972)4.08518110
20regulation of mitochondrial translation (GO:0070129)4.08100057
21superoxide anion generation (GO:0042554)4.00235594
22translational initiation (GO:0006413)4.00138182
23neutrophil activation involved in immune response (GO:0002283)3.96749295
24mitochondrial respiratory chain complex assembly (GO:0033108)3.94449200
25translation (GO:0006412)3.91453782
26protein complex biogenesis (GO:0070271)3.90201630
27respiratory electron transport chain (GO:0022904)3.89169613
28histone exchange (GO:0043486)3.86016508
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.84300266
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.81877077
31NADH dehydrogenase complex assembly (GO:0010257)3.81877077
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81877077
33DNA strand elongation involved in DNA replication (GO:0006271)3.79501911
34electron transport chain (GO:0022900)3.79390430
35pseudouridine synthesis (GO:0001522)3.74217498
36purine nucleobase biosynthetic process (GO:0009113)3.68512976
37telomere maintenance via semi-conservative replication (GO:0032201)3.67840880
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.66080279
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.65129857
40protein neddylation (GO:0045116)3.64934181
41cellular protein complex disassembly (GO:0043624)3.63735693
42viral life cycle (GO:0019058)3.63515382
43DNA strand elongation (GO:0022616)3.61956017
44protein localization to kinetochore (GO:0034501)3.58106731
45DNA replication-independent nucleosome organization (GO:0034724)3.52705125
46DNA replication-independent nucleosome assembly (GO:0006336)3.52705125
47nucleobase biosynthetic process (GO:0046112)3.52316028
48cellular component biogenesis (GO:0044085)3.51070632
49spliceosomal snRNP assembly (GO:0000387)3.48935252
50rRNA metabolic process (GO:0016072)3.48375134
51formation of translation preinitiation complex (GO:0001731)3.44672055
52negative regulation of ligase activity (GO:0051352)3.41009104
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41009104
54immunoglobulin mediated immune response (GO:0016064)3.39213999
55respiratory chain complex IV assembly (GO:0008535)3.35076651
56natural killer cell mediated immunity (GO:0002228)3.34375516
57natural killer cell mediated cytotoxicity (GO:0042267)3.34375516
58establishment of viral latency (GO:0019043)3.32666880
59protein targeting to mitochondrion (GO:0006626)3.30947738
60maturation of 5.8S rRNA (GO:0000460)3.30076423
61negative regulation by host of viral transcription (GO:0043922)3.29455652
62hydrogen peroxide biosynthetic process (GO:0050665)3.26681395
63telomere maintenance via recombination (GO:0000722)3.25819711
64histone mRNA metabolic process (GO:0008334)3.25674786
65IMP biosynthetic process (GO:0006188)3.24568189
66cytochrome complex assembly (GO:0017004)3.23765383
67positive regulation of interferon-alpha production (GO:0032727)3.22910821
68DNA damage response, detection of DNA damage (GO:0042769)3.20648482
69kinetochore assembly (GO:0051382)3.17716286
70DNA ligation (GO:0006266)3.17583055
71respiratory burst (GO:0045730)3.17242874
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17112571
73regulation of mitotic spindle checkpoint (GO:1903504)3.17112571
74DNA double-strand break processing (GO:0000729)3.16598148
75nuclear-transcribed mRNA catabolic process (GO:0000956)3.16160687
76mitotic recombination (GO:0006312)3.15762434
77protein complex disassembly (GO:0043241)3.14751652
78granulocyte activation (GO:0036230)3.14645774
79kinetochore organization (GO:0051383)3.11788725
80positive regulation by symbiont of host defense response (GO:0052509)3.09413469
81modulation by symbiont of host defense response (GO:0052031)3.09413469
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09413469
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09413469
84positive regulation by organism of defense response of other organism involved in symbiotic interact3.09413469
85modulation by symbiont of host immune response (GO:0052553)3.09413469
86macromolecular complex disassembly (GO:0032984)3.09305470
87regulation of RIG-I signaling pathway (GO:0039535)3.07500818
88regulation of helicase activity (GO:0051095)3.07024761
89establishment of protein localization to mitochondrion (GO:0072655)3.05073821
90regulation of interferon-alpha production (GO:0032647)3.03748286
91transcription-coupled nucleotide-excision repair (GO:0006283)3.03615657
92rRNA methylation (GO:0031167)3.03491215
93protein localization to mitochondrion (GO:0070585)3.03171932
94B cell mediated immunity (GO:0019724)3.03085904
95reactive oxygen species biosynthetic process (GO:1903409)3.02780679
96positive regulation of chemokine biosynthetic process (GO:0045080)3.01951068
97metaphase plate congression (GO:0051310)3.01456067
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01202306
99neutrophil activation (GO:0042119)2.99417691
100mRNA catabolic process (GO:0006402)2.99351444
101folic acid-containing compound biosynthetic process (GO:0009396)2.97615107
102oxidative phosphorylation (GO:0006119)2.96849112
103inner mitochondrial membrane organization (GO:0007007)2.95834150
104regulation of chemokine biosynthetic process (GO:0045073)2.95421110
105transcription from mitochondrial promoter (GO:0006390)2.95359076
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95086990
107proteasome assembly (GO:0043248)2.95077195
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94117819
109tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94117819
110cellular response to interferon-beta (GO:0035458)2.93818297
111ribosome assembly (GO:0042255)2.91443681
112lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85136923
113antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80820515
114negative regulation of viral genome replication (GO:0045071)2.80008653
115protein K6-linked ubiquitination (GO:0085020)2.77405916
116response to interferon-alpha (GO:0035455)2.76765278
117defense response to protozoan (GO:0042832)2.76711185
118cellular response to interferon-alpha (GO:0035457)2.76512424
119cellular response to type I interferon (GO:0071357)2.76492513
120type I interferon signaling pathway (GO:0060337)2.76492513
121mitotic metaphase plate congression (GO:0007080)2.75896786
122response to interferon-beta (GO:0035456)2.72744021
123positive regulation of interferon-beta production (GO:0032728)2.72515830
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.70368699
125response to type I interferon (GO:0034340)2.69442784
126positive regulation of type 2 immune response (GO:0002830)2.67124918
127regulation of activation of Janus kinase activity (GO:0010533)2.66352437
128regulation of fever generation (GO:0031620)2.66331601
129CENP-A containing nucleosome assembly (GO:0034080)2.65700171
130regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.65591446
131ribosomal large subunit biogenesis (GO:0042273)2.64704727
132transcription elongation from RNA polymerase III promoter (GO:0006385)2.64657935
133termination of RNA polymerase III transcription (GO:0006386)2.64657935
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64369356
135positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.62147743
136positive regulation of heat generation (GO:0031652)2.60097941
137ribosome biogenesis (GO:0042254)2.59435565
138DNA deamination (GO:0045006)2.57929330
139regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.57598491
140regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.57536609
141chromatin remodeling at centromere (GO:0031055)2.56772622
142rRNA modification (GO:0000154)2.55920895
143DNA replication checkpoint (GO:0000076)2.55558551
144positive regulation of lymphocyte migration (GO:2000403)2.54276304
145production of molecular mediator involved in inflammatory response (GO:0002532)2.54007537
146negative regulation of myeloid cell apoptotic process (GO:0033033)2.53437151
147leukocyte mediated cytotoxicity (GO:0001909)2.51986451
148positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.51648648
149meiotic chromosome segregation (GO:0045132)2.51257667
150transcription elongation from RNA polymerase I promoter (GO:0006362)2.50723852
151positive regulation of interleukin-17 production (GO:0032740)2.49885069
152regulation of immunoglobulin secretion (GO:0051023)2.48542367
153DNA catabolic process, exonucleolytic (GO:0000738)2.45335747
154NIK/NF-kappaB signaling (GO:0038061)2.45184173
155negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.44160409
156ribonucleoprotein complex biogenesis (GO:0022613)2.42579480
157regulation of double-strand break repair via homologous recombination (GO:0010569)2.42558133
158transcription from RNA polymerase I promoter (GO:0006360)2.41532505
159deoxyribonucleotide biosynthetic process (GO:0009263)2.40872509
160positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.40146094
161negative regulation of DNA-dependent DNA replication (GO:2000104)2.39538261
162DNA replication initiation (GO:0006270)2.39172810
163maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38431685
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.38141068
165anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.36844913
166regulation of vitamin D biosynthetic process (GO:0060556)2.36493919
167termination of RNA polymerase I transcription (GO:0006363)2.35316606
168cellular response to exogenous dsRNA (GO:0071360)2.35241280
169DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.34840596
170monocyte chemotaxis (GO:0002548)2.34453029
171signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.33920999
172signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.33920999
173signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.33920999
174positive regulation of T cell cytokine production (GO:0002726)2.33635239
175regulation of nuclear cell cycle DNA replication (GO:0033262)2.33542383
176T-helper 1 type immune response (GO:0042088)2.33117378
177pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.32981884
178rRNA processing (GO:0006364)2.32385368
179superoxide metabolic process (GO:0006801)2.31917396
180intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.31696158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.86002946
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.60836137
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.36157441
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.86900817
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63509625
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.30630210
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.03392591
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99415704
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95211077
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.76615079
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.74365451
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41256666
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40870150
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34476001
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32408403
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28427494
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.24960590
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.19823778
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16214762
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14721052
21ELK1_19687146_ChIP-ChIP_HELA_Human2.13973003
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12401838
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10048653
24VDR_23849224_ChIP-Seq_CD4+_Human2.10029481
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.08160805
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05367334
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03391866
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01026641
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92207023
30MYC_18940864_ChIP-ChIP_HL60_Human1.84779315
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83320763
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74787363
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.71435464
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71021198
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70929665
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70908646
37* SPI1_23547873_ChIP-Seq_NB4_Human1.66727339
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66408225
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64357111
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63444536
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62745477
42DCP1A_22483619_ChIP-Seq_HELA_Human1.61412348
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59634542
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56472760
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56067749
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53734600
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53590979
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49968319
49FOXP3_21729870_ChIP-Seq_TREG_Human1.48512105
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.46057020
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45087048
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45015033
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44681631
54EWS_26573619_Chip-Seq_HEK293_Human1.44520845
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43151950
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.40156027
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.37139980
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36613040
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.35574663
60VDR_22108803_ChIP-Seq_LS180_Human1.34262468
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33903303
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32249052
63XRN2_22483619_ChIP-Seq_HELA_Human1.32013300
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31975762
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30877403
66FUS_26573619_Chip-Seq_HEK293_Human1.29753695
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29121750
68ZNF274_21170338_ChIP-Seq_K562_Hela1.28620041
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.27886700
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24693069
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24632104
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22873508
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22442968
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22374917
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21347162
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.19938225
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.19640847
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19320886
79TTF2_22483619_ChIP-Seq_HELA_Human1.17232644
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.15500997
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14667263
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12685149
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10594328
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10129774
85GABP_19822575_ChIP-Seq_HepG2_Human1.08531431
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08106369
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08106369
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08106369
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08065893
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07844143
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07529381
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06838117
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05950660
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05859099
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05848492
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03246763
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00981167
98TFEB_21752829_ChIP-Seq_HELA_Human1.00873675
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00505708
100AR_21909140_ChIP-Seq_LNCAP_Human0.95815373
101THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94198172
102PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91851628
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91060075
104SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90634463
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90144387
106PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88631359
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86979903
108NFE2_27457419_Chip-Seq_LIVER_Mouse0.86500063
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.86486231
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84999941
111KDM5A_27292631_Chip-Seq_BREAST_Human0.84105289
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82455960
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81663549
114SALL1_21062744_ChIP-ChIP_HESCs_Human0.81649034
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.81619137
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80871267
117PU_27001747_Chip-Seq_BMDM_Mouse0.80620676
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80444497
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80224437
120IGF1R_20145208_ChIP-Seq_DFB_Human0.79992738
121IRF1_19129219_ChIP-ChIP_H3396_Human0.79620415
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78861178
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.75690277
124ELF5_23300383_ChIP-Seq_T47D_Human0.75462179
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73953509
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73563237
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72362261
128CIITA_25753668_ChIP-Seq_RAJI_Human0.69720779
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69643082
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68844428
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.67494818
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.67490692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.70935706
2MP0009785_altered_susceptibility_to3.63403948
3MP0002148_abnormal_hypersensitivity_rea3.42900167
4MP0009379_abnormal_foot_pigmentation3.33592042
5MP0003693_abnormal_embryo_hatching3.20968571
6MP0008057_abnormal_DNA_replication3.07742458
7MP0003724_increased_susceptibility_to2.90157785
8MP0003436_decreased_susceptibility_to2.71395289
9MP0008058_abnormal_DNA_repair2.71059294
10MP0005025_abnormal_response_to2.64337030
11MP0006082_CNS_inflammation2.63139966
12MP0010094_abnormal_chromosome_stability2.60243862
13MP0005000_abnormal_immune_tolerance2.59609962
14MP0002419_abnormal_innate_immunity2.57742904
15MP0003111_abnormal_nucleus_morphology2.52308488
16MP0009697_abnormal_copulation2.44482958
17MP0005671_abnormal_response_to2.39889307
18MP0003806_abnormal_nucleotide_metabolis2.27875631
19MP0003077_abnormal_cell_cycle2.23934636
20MP0002452_abnormal_antigen_presenting2.19471511
21MP0002723_abnormal_immune_serum2.16899898
22MP0008789_abnormal_olfactory_epithelium2.07114644
23MP0002938_white_spotting2.02766296
24MP0001800_abnormal_humoral_immune2.02322258
25MP0003136_yellow_coat_color1.99295575
26MP0009333_abnormal_splenocyte_physiolog1.97789109
27MP0001790_abnormal_immune_system1.91850804
28MP0005387_immune_system_phenotype1.91850804
29MP0004957_abnormal_blastocyst_morpholog1.89573121
30MP0001819_abnormal_immune_cell1.88856415
31MP0002420_abnormal_adaptive_immunity1.84725277
32MP0002277_abnormal_respiratory_mucosa1.78864608
33MP0003186_abnormal_redox_activity1.74353834
34MP0006072_abnormal_retinal_apoptosis1.73837640
35MP0003448_altered_tumor_morphology1.73746211
36MP0008007_abnormal_cellular_replicative1.73532379
37MP0000685_abnormal_immune_system1.72377573
38MP0006035_abnormal_mitochondrial_morpho1.66281568
39MP0003718_maternal_effect1.61563976
40MP0001529_abnormal_vocalization1.60817123
41MP0006292_abnormal_olfactory_placode1.60704205
42MP0003303_peritoneal_inflammation1.59563373
43MP0010307_abnormal_tumor_latency1.59186573
44MP0006036_abnormal_mitochondrial_physio1.58753844
45MP0001853_heart_inflammation1.57575880
46MP0008260_abnormal_autophagy1.56901867
47MP0002006_tumorigenesis1.53800963
48MP0000858_altered_metastatic_potential1.51018713
49MP0002160_abnormal_reproductive_system1.50479535
50MP0008932_abnormal_embryonic_tissue1.47663314
51MP0002405_respiratory_system_inflammati1.46931132
52MP0003890_abnormal_embryonic-extraembry1.46404162
53MP0010030_abnormal_orbit_morphology1.44280337
54MP0000716_abnormal_immune_system1.42998329
55MP0009764_decreased_sensitivity_to1.42519818
56MP0003567_abnormal_fetal_cardiomyocyte1.42368381
57MP0003786_premature_aging1.42036041
58MP0002398_abnormal_bone_marrow1.41963789
59MP0001845_abnormal_inflammatory_respons1.36622367
60MP0002234_abnormal_pharynx_morphology1.36065527
61MP0005394_taste/olfaction_phenotype1.34000734
62MP0005499_abnormal_olfactory_system1.34000734
63MP0008995_early_reproductive_senescence1.33335121
64MP0001533_abnormal_skeleton_physiology1.32547754
65MP0003937_abnormal_limbs/digits/tail_de1.31672328
66MP0002396_abnormal_hematopoietic_system1.31276233
67MP0003315_abnormal_perineum_morphology1.30215574
68MP0001697_abnormal_embryo_size1.28718985
69MP0005397_hematopoietic_system_phenotyp1.24350447
70MP0001545_abnormal_hematopoietic_system1.24350447
71MP0008469_abnormal_protein_level1.20812449
72MP0002429_abnormal_blood_cell1.20609095
73MP0001286_abnormal_eye_development1.20575499
74MP0004947_skin_inflammation1.20076339
75MP0005084_abnormal_gallbladder_morpholo1.19897512
76MP0000490_abnormal_crypts_of1.18712764
77MP0002085_abnormal_embryonic_tissue1.18235361
78MP0005464_abnormal_platelet_physiology1.17611129
79MP0000049_abnormal_middle_ear1.16974876
80MP0001293_anophthalmia1.16208965
81MP0002233_abnormal_nose_morphology1.15393202
82MP0000689_abnormal_spleen_morphology1.13923146
83MP0002722_abnormal_immune_system1.13316607
84MP0000383_abnormal_hair_follicle1.10357435
85MP0000015_abnormal_ear_pigmentation1.10158465
86MP0010155_abnormal_intestine_physiology1.09676359
87MP0002084_abnormal_developmental_patter1.09281759
88MP0005451_abnormal_body_composition1.08842999
89MP0001929_abnormal_gametogenesis1.07360430
90MP0001672_abnormal_embryogenesis/_devel1.06630890
91MP0005380_embryogenesis_phenotype1.06630890
92MP0003828_pulmonary_edema1.06470505
93MP0004808_abnormal_hematopoietic_stem1.05932791
94MP0002697_abnormal_eye_size1.05068568
95MP0005171_absent_coat_pigmentation1.05031276
96MP0000350_abnormal_cell_proliferation1.04594193
97MP0003941_abnormal_skin_development1.04566037
98MP0001145_abnormal_male_reproductive1.02911854
99MP0001485_abnormal_pinna_reflex1.02746489
100MP0002163_abnormal_gland_morphology1.02603612
101MP0004510_myositis1.02029636
102MP0005389_reproductive_system_phenotype1.01638281
103MP0000313_abnormal_cell_death1.01620780
104MP0001764_abnormal_homeostasis1.01315702
105MP0002837_dystrophic_cardiac_calcinosis0.99167669
106MP0000631_abnormal_neuroendocrine_gland0.99056166
107MP0000653_abnormal_sex_gland0.98660188
108MP0005174_abnormal_tail_pigmentation0.97470373
109MP0008877_abnormal_DNA_methylation0.95530606
110MP0000358_abnormal_cell_content/0.94261212
111MP0002080_prenatal_lethality0.93849239
112MP0009278_abnormal_bone_marrow0.93181053
113MP0003119_abnormal_digestive_system0.92888569
114MP0010352_gastrointestinal_tract_polyps0.91655432
115MP0003011_delayed_dark_adaptation0.91222282
116MP0002019_abnormal_tumor_incidence0.90143616
117MP0002111_abnormal_tail_morphology0.89073427
118MP0001188_hyperpigmentation0.88528438
119MP0000372_irregular_coat_pigmentation0.87502467
120MP0002095_abnormal_skin_pigmentation0.87169892
121MP0003763_abnormal_thymus_physiology0.85461917
122MP0002132_abnormal_respiratory_system0.84809455
123MP0003121_genomic_imprinting0.84137743
124MP0003984_embryonic_growth_retardation0.83675079
125MP0001881_abnormal_mammary_gland0.82809279
126MP0002088_abnormal_embryonic_growth/wei0.82753197
127MP0004147_increased_porphyrin_level0.82752112
128MP0000647_abnormal_sebaceous_gland0.81335937
129MP0002751_abnormal_autonomic_nervous0.79987982
130MP0004381_abnormal_hair_follicle0.79544905
131MP0005058_abnormal_lysosome_morphology0.77649085
132MP0002210_abnormal_sex_determination0.77452563
133MP0005391_vision/eye_phenotype0.77063625
134MP0005253_abnormal_eye_physiology0.75194991
135MP0003938_abnormal_ear_development0.74556379
136MP0002998_abnormal_bone_remodeling0.74438791
137MP0001346_abnormal_lacrimal_gland0.74062469
138MP0000343_altered_response_to0.74061594
139MP0000703_abnormal_thymus_morphology0.74010568
140MP0002102_abnormal_ear_morphology0.73937134
141MP0008004_abnormal_stomach_pH0.73748338
142MP0009250_abnormal_appendicular_skeleto0.73206947
143MP0005390_skeleton_phenotype0.72862965
144MP0000627_abnormal_mammary_gland0.72854652
145MP0005310_abnormal_salivary_gland0.72414734
146MP0009672_abnormal_birth_weight0.72157096
147MP0003123_paternal_imprinting0.71791683
148MP0004197_abnormal_fetal_growth/weight/0.71100827
149MP0001119_abnormal_female_reproductive0.70233489
150MP0000537_abnormal_urethra_morphology0.70173536
151MP0001730_embryonic_growth_arrest0.70018430
152MP0003755_abnormal_palate_morphology0.66923329
153MP0003698_abnormal_male_reproductive0.65940750
154MP0002638_abnormal_pupillary_reflex0.64205641
155MP0001986_abnormal_taste_sensitivity0.63341217
156MP0005408_hypopigmentation0.63281439
157MP0003950_abnormal_plasma_membrane0.63079748
158MP0004782_abnormal_surfactant_physiolog0.62950613
159MP0001919_abnormal_reproductive_system0.62931410
160MP0000579_abnormal_nail_morphology0.62503908
161MP0002736_abnormal_nociception_after0.62357922
162MP0008872_abnormal_physiological_respon0.61846500
163MP0009763_increased_sensitivity_to0.61181414
164MP0004215_abnormal_myocardial_fiber0.60929285
165MP0000371_diluted_coat_color0.60033252
166MP0003646_muscle_fatigue0.57047908
167MP0005395_other_phenotype0.55662413

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.70515401
2Acute necrotizing encephalopathy (HP:0006965)5.10364742
3Eczematoid dermatitis (HP:0000976)5.05118980
4Recurrent bacterial skin infections (HP:0005406)4.97511863
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.58140126
6Abnormal mitochondria in muscle tissue (HP:0008316)4.56503966
7Acute encephalopathy (HP:0006846)4.44144474
8Mitochondrial inheritance (HP:0001427)4.37373130
9Increased hepatocellular lipid droplets (HP:0006565)4.34499289
10Chromsome breakage (HP:0040012)4.30924962
11Progressive macrocephaly (HP:0004481)4.20449450
12Mediastinal lymphadenopathy (HP:0100721)4.14934404
13Increased CSF lactate (HP:0002490)4.10230958
14Lipid accumulation in hepatocytes (HP:0006561)3.93171648
15Recurrent gram-negative bacterial infections (HP:0005420)3.89907900
16Abnormality of cells of the erythroid lineage (HP:0012130)3.82074541
17Macrocytic anemia (HP:0001972)3.81151552
18Prostate neoplasm (HP:0100787)3.79593173
19Abnormal number of erythroid precursors (HP:0012131)3.76557700
20Hepatocellular necrosis (HP:0001404)3.66849012
21Stomatitis (HP:0010280)3.64996309
22Abnormality of macrophages (HP:0004311)3.64137384
23Chronic obstructive pulmonary disease (HP:0006510)3.59094203
24Obstructive lung disease (HP:0006536)3.59094203
25Birth length less than 3rd percentile (HP:0003561)3.45173686
26Cerebral edema (HP:0002181)3.39402176
27Hepatic necrosis (HP:0002605)3.36627378
28Colon cancer (HP:0003003)3.35415302
29Parakeratosis (HP:0001036)3.21607025
30Renal Fanconi syndrome (HP:0001994)3.10260039
31Duplicated collecting system (HP:0000081)3.10175817
32Recurrent skin infections (HP:0001581)3.05653925
33Elevated erythrocyte sedimentation rate (HP:0003565)3.04684061
34Increased IgM level (HP:0003496)3.01036896
35Aplastic anemia (HP:0001915)2.98818738
363-Methylglutaconic aciduria (HP:0003535)2.96065688
37Cleft eyelid (HP:0000625)2.95093886
38Increased serum lactate (HP:0002151)2.94023853
39Gingivitis (HP:0000230)2.89615988
40Methylmalonic acidemia (HP:0002912)2.81679964
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79698160
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79698160
43Recurrent pneumonia (HP:0006532)2.76805589
44Reticulocytopenia (HP:0001896)2.69111396
45Autoimmune thrombocytopenia (HP:0001973)2.68014958
46Recurrent fungal infections (HP:0002841)2.66801068
47Basal ganglia calcification (HP:0002135)2.65371138
48Leukodystrophy (HP:0002415)2.63386237
49Meckel diverticulum (HP:0002245)2.62648487
50Poor head control (HP:0002421)2.62262288
51Breast hypoplasia (HP:0003187)2.62183259
52Agnosia (HP:0010524)2.61106441
53Abnormality of the preputium (HP:0100587)2.60317449
54Lactic acidosis (HP:0003128)2.60073435
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57559760
56Abnormality of methionine metabolism (HP:0010901)2.57301882
57Abnormality of chromosome stability (HP:0003220)2.56993613
58Increased intramyocellular lipid droplets (HP:0012240)2.56886173
59Abnormality of the renal collecting system (HP:0004742)2.56004483
60Abnormality of the ileum (HP:0001549)2.52866287
61Congenital, generalized hypertrichosis (HP:0004540)2.50386122
62Respiratory failure (HP:0002878)2.49425829
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.49078300
64Oral leukoplakia (HP:0002745)2.49043869
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.47426017
66Type I transferrin isoform profile (HP:0003642)2.47191656
67Rough bone trabeculation (HP:0100670)2.46772036
68Optic neuritis (HP:0100653)2.46006951
69Retrobulbar optic neuritis (HP:0100654)2.46006951
70Bone marrow hypocellularity (HP:0005528)2.45387514
71Ectopic kidney (HP:0000086)2.42796159
72Abnormality of alanine metabolism (HP:0010916)2.42340172
73Hyperalaninemia (HP:0003348)2.42340172
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42340172
75Exercise intolerance (HP:0003546)2.41961778
76Vasculitis (HP:0002633)2.35916081
77Respiratory difficulties (HP:0002880)2.34904820
78Microvesicular hepatic steatosis (HP:0001414)2.33317055
79Increased serum pyruvate (HP:0003542)2.32875534
80Abnormality of the labia minora (HP:0012880)2.32435990
81Absent radius (HP:0003974)2.32087806
82Pustule (HP:0200039)2.31965330
83Clubbing of toes (HP:0100760)2.31672282
84Prolonged neonatal jaundice (HP:0006579)2.29110955
85Recurrent lower respiratory tract infections (HP:0002783)2.28554651
86Recurrent viral infections (HP:0004429)2.25523394
87Abnormal trabecular bone morphology (HP:0100671)2.23810291
88Methylmalonic aciduria (HP:0012120)2.22584861
89Carpal bone hypoplasia (HP:0001498)2.20558101
90Premature graying of hair (HP:0002216)2.20450589
91Optic disc pallor (HP:0000543)2.18641499
92Megaloblastic anemia (HP:0001889)2.18413270
93Abnormality of serum amino acid levels (HP:0003112)2.18365602
94Abnormal lung lobation (HP:0002101)2.17770364
95Chronic mucocutaneous candidiasis (HP:0002728)2.14854417
96Recurrent cutaneous fungal infections (HP:0011370)2.14854417
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14077150
98Abnormal protein N-linked glycosylation (HP:0012347)2.14077150
99Abnormal protein glycosylation (HP:0012346)2.14077150
100Abnormal glycosylation (HP:0012345)2.14077150
101Abnormality of the prostate (HP:0008775)2.10830289
102Absent forearm bone (HP:0003953)2.10513712
103Aplasia involving forearm bones (HP:0009822)2.10513712
104Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09232940
105Tracheoesophageal fistula (HP:0002575)2.08887489
106Hepatosplenomegaly (HP:0001433)2.07263309
107Lethargy (HP:0001254)2.07236937
108Leukopenia (HP:0001882)2.07112342
109Pancytopenia (HP:0001876)2.05789860
110Hyperglycinemia (HP:0002154)2.05418817
111Thick nail (HP:0001805)2.05008174
112Myelodysplasia (HP:0002863)2.04048607
113Orchitis (HP:0100796)2.03904502
114Leukocytosis (HP:0001974)2.03650249
115Increased muscle lipid content (HP:0009058)2.01241328
116Reduced antithrombin III activity (HP:0001976)2.00904299
117Abnormality of homocysteine metabolism (HP:0010919)2.00371441
118Homocystinuria (HP:0002156)2.00371441
119Stenosis of the external auditory canal (HP:0000402)1.99720473
120Lymphoma (HP:0002665)1.99171935
121Premature loss of primary teeth (HP:0006323)1.98856482
122Multiple enchondromatosis (HP:0005701)1.98666278
123Fused cervical vertebrae (HP:0002949)1.97320477
124Petechiae (HP:0000967)1.97067687
125Abnormality of the anterior horn cell (HP:0006802)1.96843191
126Degeneration of anterior horn cells (HP:0002398)1.96843191
127Pallor (HP:0000980)1.96838259
128Abnormality of glycolysis (HP:0004366)1.96409861
129Pancreatic cysts (HP:0001737)1.96272682
130Myositis (HP:0100614)1.96124975
131Abnormality of the duodenum (HP:0002246)1.95838848
132Absent septum pellucidum (HP:0001331)1.95826823
133Cellulitis (HP:0100658)1.94412730
134Abnormality of renal resorption (HP:0011038)1.94375099
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94074630
136Triphalangeal thumb (HP:0001199)1.91490528
137Pancreatic fibrosis (HP:0100732)1.91146163
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90603645
139Absent thumb (HP:0009777)1.89607034
140Patellar aplasia (HP:0006443)1.88366438
141Sparse eyelashes (HP:0000653)1.87907700
142IgG deficiency (HP:0004315)1.86217055
143Porencephaly (HP:0002132)1.85931008
144Septo-optic dysplasia (HP:0100842)1.85299936
145Hypoplasia of the pons (HP:0012110)1.83602421
146Amniotic constriction ring (HP:0009775)1.83494516
147Abnormality of placental membranes (HP:0011409)1.83494516
148Abnormality of the septum pellucidum (HP:0007375)1.83438253
149Nausea (HP:0002018)1.82307986
150Meningitis (HP:0001287)1.81715526
151Horseshoe kidney (HP:0000085)1.79982716
152Vacuolated lymphocytes (HP:0001922)1.79626626
153Pendular nystagmus (HP:0012043)1.79462475
154Small intestinal stenosis (HP:0012848)1.78777193
155Duodenal stenosis (HP:0100867)1.78777193
156Eosinophilia (HP:0001880)1.77676690
157Aplasia/Hypoplasia of the patella (HP:0006498)1.77567811
158Abnormal number of incisors (HP:0011064)1.77460542
159Abnormality of the pons (HP:0007361)1.77105789
160Impulsivity (HP:0100710)1.76110604
161Exertional dyspnea (HP:0002875)1.75859438
162Periodontitis (HP:0000704)1.74644847
163Molar tooth sign on MRI (HP:0002419)1.74373294
164Abnormality of midbrain morphology (HP:0002418)1.74373294
165Urticaria (HP:0001025)1.73830022
166Sloping forehead (HP:0000340)1.73356355
167CNS demyelination (HP:0007305)1.72811892
168Cerebral hypomyelination (HP:0006808)1.72356067
169Rectal fistula (HP:0100590)1.72134418
170Rectovaginal fistula (HP:0000143)1.72134418
171Abnormality of eosinophils (HP:0001879)1.72030358
172Abnormality of the carotid arteries (HP:0005344)1.71825857
173Conical tooth (HP:0000698)1.71766521
174Cellular immunodeficiency (HP:0005374)1.71569085
175Abnormality of T cell number (HP:0011839)1.70745123
176Amaurosis fugax (HP:0100576)1.69579655
177Abnormality of DNA repair (HP:0003254)1.68794722
178Granulocytopenia (HP:0001913)1.67894497
179Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67196494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.17045130
2VRK24.64585643
3IRAK33.21326579
4IRAK43.05664050
5MAP3K142.98654522
6EIF2AK12.92875777
7BLK2.62871489
8TAF12.58919432
9BUB12.57263310
10NUAK12.53915990
11RIPK42.48095059
12NEK12.37622903
13STK162.25959742
14WEE12.23588988
15PLK42.19551870
16NME22.18851167
17EIF2AK22.08571019
18IKBKB2.01607554
19PIM21.95473598
20SRPK11.95289626
21TXK1.92302644
22NME11.87790901
23EIF2AK31.74394500
24ZAK1.68183198
25TBK11.61489318
26MKNK11.59379320
27IKBKE1.56606629
28STK41.52987252
29TLK11.48888482
30YES11.48731224
31VRK11.47291012
32MKNK21.46521523
33TYK21.46084629
34MST41.44080873
35JAK31.39564987
36CDK191.35540610
37RPS6KA41.27688606
38TNIK1.23586020
39PIM11.21799494
40BRSK21.21080991
41WNK31.19639814
42CDC71.17455582
43PLK11.11771474
44PASK1.11377359
45BMPR21.09760686
46CCNB11.09446335
47NEK61.07848982
48TTK1.07405397
49ATR1.06376217
50MAPKAPK51.04804964
51CDK81.03173419
52TRIM281.01276116
53MARK30.98664354
54ABL20.98322046
55PLK30.98150267
56ACVR1B0.98143244
57CHUK0.96274500
58MAP4K10.95608466
59BRD40.94322284
60NEK20.93622161
61TSSK60.93523888
62CLK10.93499647
63MAP3K130.93245428
64CDK70.92751429
65BCR0.88437630
66BCKDK0.85254889
67LYN0.85113427
68NEK90.84150143
69PDK20.84072289
70EPHA20.83729540
71MAP4K20.81010043
72ERBB40.79932528
73PNCK0.79402397
74RPS6KB20.75047930
75KIT0.74240026
76AURKB0.73821647
77DYRK30.72248763
78AKT30.71919994
79PLK20.70820558
80STK38L0.70238026
81BRSK10.70154392
82CDK120.69508932
83IRAK10.68023143
84CHEK20.67115154
85ALK0.66857955
86MUSK0.66621080
87TESK20.65803901
88LCK0.65026486
89STK30.64739686
90TGFBR10.64346175
91RPS6KA50.63606979
92BMPR1B0.63435541
93OXSR10.60557671
94TEC0.60256487
95JAK10.60128604
96IRAK20.58144765
97CSNK1G10.56157140
98SYK0.55852961
99CSK0.55768610
100CSNK2A10.54347363
101CHEK10.54332939
102FGR0.54142747
103CDK40.53818690
104MELK0.53344764
105ARAF0.52072202
106CSNK1E0.52059386
107ADRBK20.50931426
108BTK0.50811852
109GRK10.50761019
110FGFR10.48042870
111DYRK20.47608922
112STK240.47337950
113DMPK0.47236975
114BRAF0.47162288
115ATM0.46656325
116MAP3K80.46414703
117CSNK1G30.45693214
118STK100.45453186
119PRKCD0.45408333
120HCK0.45250308
121BMX0.44309364
122MAP3K50.43496895
123ABL10.42418532
124CDK30.41368616
125CSNK2A20.40924855
126CSNK1G20.40256070
127MET0.39907962
128CDK20.39655253
129CDK10.39216062
130WNK40.37661447
131ZAP700.37525319
132DAPK10.37359531
133ERBB30.36007731
134AURKA0.35629740
135TRPM70.35580359
136SIK30.35473846
137CDK90.35098584
138SCYL20.33763152
139PRKDC0.33745708
140INSRR0.33403346
141STK390.32761097
142MAP3K100.32745368
143ILK0.29524034
144NLK0.29505223
145PRKCG0.27661393
146CSNK1A1L0.27334657
147KDR0.25960210
148FRK0.25284346
149PAK40.23868355

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.46724332
2Proteasome_Homo sapiens_hsa030503.15843594
3Parkinsons disease_Homo sapiens_hsa050123.11671279
4Graft-versus-host disease_Homo sapiens_hsa053322.94009923
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72524490
6RNA polymerase_Homo sapiens_hsa030202.66088256
7DNA replication_Homo sapiens_hsa030302.35043488
8Allograft rejection_Homo sapiens_hsa053302.33840281
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.19789192
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15767610
11Legionellosis_Homo sapiens_hsa051342.15301068
12Homologous recombination_Homo sapiens_hsa034402.13941180
13Leishmaniasis_Homo sapiens_hsa051402.04963397
14Mismatch repair_Homo sapiens_hsa034302.01783492
15Ribosome_Homo sapiens_hsa030101.99030848
16Alzheimers disease_Homo sapiens_hsa050101.95989102
17Fanconi anemia pathway_Homo sapiens_hsa034601.86438310
18Asthma_Homo sapiens_hsa053101.83776521
19Spliceosome_Homo sapiens_hsa030401.83330531
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81849604
21Pyrimidine metabolism_Homo sapiens_hsa002401.81247189
22Herpes simplex infection_Homo sapiens_hsa051681.80109925
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77893381
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76832387
25Type I diabetes mellitus_Homo sapiens_hsa049401.76197935
26Measles_Homo sapiens_hsa051621.71381571
27RNA transport_Homo sapiens_hsa030131.67827100
28Rheumatoid arthritis_Homo sapiens_hsa053231.66189018
29Basal transcription factors_Homo sapiens_hsa030221.63240566
30Base excision repair_Homo sapiens_hsa034101.61570451
31One carbon pool by folate_Homo sapiens_hsa006701.59966556
32Malaria_Homo sapiens_hsa051441.49773550
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.48068766
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47736572
35Nucleotide excision repair_Homo sapiens_hsa034201.45938036
36Influenza A_Homo sapiens_hsa051641.39370347
37Pertussis_Homo sapiens_hsa051331.35198324
38Staphylococcus aureus infection_Homo sapiens_hsa051501.33607012
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.31280526
40Cell cycle_Homo sapiens_hsa041101.30053945
41Autoimmune thyroid disease_Homo sapiens_hsa053201.27811381
42Hematopoietic cell lineage_Homo sapiens_hsa046401.27357106
43Non-homologous end-joining_Homo sapiens_hsa034501.27176531
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26688588
45Cardiac muscle contraction_Homo sapiens_hsa042601.26215369
46Pyruvate metabolism_Homo sapiens_hsa006201.25291309
47TNF signaling pathway_Homo sapiens_hsa046681.22703653
48Epstein-Barr virus infection_Homo sapiens_hsa051691.22624433
49Tuberculosis_Homo sapiens_hsa051521.22485040
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19019123
51Propanoate metabolism_Homo sapiens_hsa006401.17887601
52Selenocompound metabolism_Homo sapiens_hsa004501.17429255
53Salmonella infection_Homo sapiens_hsa051321.16650554
54RNA degradation_Homo sapiens_hsa030181.11004835
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08876516
56African trypanosomiasis_Homo sapiens_hsa051431.05907139
57p53 signaling pathway_Homo sapiens_hsa041151.04296872
58Antigen processing and presentation_Homo sapiens_hsa046120.97314092
59Osteoclast differentiation_Homo sapiens_hsa043800.96662081
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94748876
61Phagosome_Homo sapiens_hsa041450.94669837
62Purine metabolism_Homo sapiens_hsa002300.89728409
63Apoptosis_Homo sapiens_hsa042100.89154463
64Primary immunodeficiency_Homo sapiens_hsa053400.88194134
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85523678
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85482237
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.82724344
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81494300
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81410584
70Systemic lupus erythematosus_Homo sapiens_hsa053220.81231420
71Protein export_Homo sapiens_hsa030600.77732551
72Glutathione metabolism_Homo sapiens_hsa004800.76791237
73Steroid biosynthesis_Homo sapiens_hsa001000.74558362
74Caffeine metabolism_Homo sapiens_hsa002320.71402029
75Metabolic pathways_Homo sapiens_hsa011000.69941669
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68981371
77mRNA surveillance pathway_Homo sapiens_hsa030150.67875298
78Viral carcinogenesis_Homo sapiens_hsa052030.67610135
79Shigellosis_Homo sapiens_hsa051310.66370382
80Hepatitis B_Homo sapiens_hsa051610.65634662
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64312743
82Toxoplasmosis_Homo sapiens_hsa051450.63936050
83Chemokine signaling pathway_Homo sapiens_hsa040620.63084507
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62062615
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61680240
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60030070
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59501651
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59349037
89Hepatitis C_Homo sapiens_hsa051600.58322741
90Vitamin B6 metabolism_Homo sapiens_hsa007500.58214545
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56172954
92Oocyte meiosis_Homo sapiens_hsa041140.55167145
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53018203
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53010469
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.52970252
96Carbon metabolism_Homo sapiens_hsa012000.52771865
97Sphingolipid metabolism_Homo sapiens_hsa006000.52603927
98Sulfur relay system_Homo sapiens_hsa041220.52299312
99Fatty acid elongation_Homo sapiens_hsa000620.51124980
100Peroxisome_Homo sapiens_hsa041460.50002655
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49285296
102Viral myocarditis_Homo sapiens_hsa054160.48702439
103Biosynthesis of amino acids_Homo sapiens_hsa012300.48268648
104Lysosome_Homo sapiens_hsa041420.48038687
105Regulation of autophagy_Homo sapiens_hsa041400.47060086
106B cell receptor signaling pathway_Homo sapiens_hsa046620.46781481
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46255757
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45910053
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44983019
110Arachidonic acid metabolism_Homo sapiens_hsa005900.44871656
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44284761
112Vitamin digestion and absorption_Homo sapiens_hsa049770.43324908
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42645988
114HTLV-I infection_Homo sapiens_hsa051660.39404341
115Folate biosynthesis_Homo sapiens_hsa007900.37969550
116Collecting duct acid secretion_Homo sapiens_hsa049660.36873178
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36716956
118Tryptophan metabolism_Homo sapiens_hsa003800.36600087
119Basal cell carcinoma_Homo sapiens_hsa052170.36452577
120N-Glycan biosynthesis_Homo sapiens_hsa005100.36130133
121Pentose phosphate pathway_Homo sapiens_hsa000300.36057046
122Phototransduction_Homo sapiens_hsa047440.35347024
123Butanoate metabolism_Homo sapiens_hsa006500.33647461
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33233223
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32963344
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32705664
127Ether lipid metabolism_Homo sapiens_hsa005650.31048918
128Small cell lung cancer_Homo sapiens_hsa052220.30994460
129Retinol metabolism_Homo sapiens_hsa008300.30494538
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29305072
131T cell receptor signaling pathway_Homo sapiens_hsa046600.28161172
132Chemical carcinogenesis_Homo sapiens_hsa052040.27675803
133Nitrogen metabolism_Homo sapiens_hsa009100.27649491
134Huntingtons disease_Homo sapiens_hsa050160.26844999
135Oxidative phosphorylation_Homo sapiens_hsa001900.26759345
136TGF-beta signaling pathway_Homo sapiens_hsa043500.25615689
137MicroRNAs in cancer_Homo sapiens_hsa052060.25473679
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24867858
139Other glycan degradation_Homo sapiens_hsa005110.24468563
140Mineral absorption_Homo sapiens_hsa049780.22689462
141Fatty acid degradation_Homo sapiens_hsa000710.21617618
142beta-Alanine metabolism_Homo sapiens_hsa004100.20707683
143Sulfur metabolism_Homo sapiens_hsa009200.20263206
144Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20247076
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19668090
146Wnt signaling pathway_Homo sapiens_hsa043100.17528798
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.16681313
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16385241
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.14676845
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14534189
151Arginine and proline metabolism_Homo sapiens_hsa003300.13226892
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12879705
153Alcoholism_Homo sapiens_hsa050340.12583284
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12575192
155Fatty acid metabolism_Homo sapiens_hsa012120.11935907
156Hedgehog signaling pathway_Homo sapiens_hsa043400.11759782
157Hippo signaling pathway_Homo sapiens_hsa043900.11012520
158Linoleic acid metabolism_Homo sapiens_hsa005910.07659053
159Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05977208
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05801175
161Tyrosine metabolism_Homo sapiens_hsa003500.02923199

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