TMA16P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kynurenine metabolic process (GO:0070189)7.47941654
2indole-containing compound catabolic process (GO:0042436)6.69493065
3indolalkylamine catabolic process (GO:0046218)6.69493065
4tryptophan catabolic process (GO:0006569)6.69493065
5positive regulation of T cell differentiation in thymus (GO:0033089)5.95465277
6tryptophan metabolic process (GO:0006568)5.67014818
7DNA deamination (GO:0045006)5.49457349
8negative regulation of nitric-oxide synthase activity (GO:0051001)5.41925059
9negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.36031562
10protein polyglutamylation (GO:0018095)5.17786706
11regulation of regulatory T cell differentiation (GO:0045589)5.08178720
12regulation of memory T cell differentiation (GO:0043380)5.07923927
13positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc5.00692132
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.89160559
15cytochrome complex assembly (GO:0017004)4.81455114
16response to gravity (GO:0009629)4.68889378
17respiratory chain complex IV assembly (GO:0008535)4.62281445
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60489643
19amine catabolic process (GO:0009310)4.57989420
20cellular biogenic amine catabolic process (GO:0042402)4.57989420
21regulation of immunoglobulin secretion (GO:0051023)4.42119219
22positive regulation of T cell cytokine production (GO:0002726)4.38017104
23negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.33210462
24negative regulation of T-helper cell differentiation (GO:0045623)4.33210462
25negative regulation of DNA-templated transcription, elongation (GO:0032785)4.28832248
26cytidine metabolic process (GO:0046087)4.23932644
27cytidine catabolic process (GO:0006216)4.23932644
28cytidine deamination (GO:0009972)4.23932644
29double-strand break repair via nonhomologous end joining (GO:0006303)4.22684164
30non-recombinational repair (GO:0000726)4.22684164
31organelle disassembly (GO:1903008)4.20612080
32DNA double-strand break processing (GO:0000729)4.18894425
33indolalkylamine metabolic process (GO:0006586)4.17608177
34ribonucleoprotein complex disassembly (GO:0032988)4.17314740
35regulation of skeletal muscle contraction (GO:0014819)4.11308373
36negative regulation of protein localization to cell surface (GO:2000009)4.05600301
37DNA catabolic process, exonucleolytic (GO:0000738)4.03403938
38regulation of sarcomere organization (GO:0060297)4.02600538
39kidney morphogenesis (GO:0060993)4.00077134
40regulation of T cell differentiation in thymus (GO:0033081)3.82484174
41regulation of T-helper 1 cell differentiation (GO:0045625)3.81817086
42benzene-containing compound metabolic process (GO:0042537)3.80970461
43regulation of thymocyte apoptotic process (GO:0070243)3.79703368
44cellular response to interferon-beta (GO:0035458)3.78575286
45negative regulation of monooxygenase activity (GO:0032769)3.74738067
46negative regulation of T cell differentiation in thymus (GO:0033085)3.70671591
47protein neddylation (GO:0045116)3.67314173
48somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.65306852
49somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.65306852
50isotype switching (GO:0045190)3.65306852
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.63434242
52negative regulation of alpha-beta T cell differentiation (GO:0046639)3.61773595
53aromatic amino acid family catabolic process (GO:0009074)3.56794370
54DNA demethylation (GO:0080111)3.51971779
55negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.50202514
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.49742104
57negative regulation of organelle assembly (GO:1902116)3.46368027
58pyrimidine ribonucleoside catabolic process (GO:0046133)3.44064959
59protein complex biogenesis (GO:0070271)3.43336811
60NAD biosynthetic process (GO:0009435)3.42444066
61maturation of 5.8S rRNA (GO:0000460)3.41725603
62negative regulation of muscle hypertrophy (GO:0014741)3.39065228
63intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.35727491
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.25354714
65negative regulation of thymocyte apoptotic process (GO:0070244)3.24618327
66regulation of T cell cytokine production (GO:0002724)3.24541766
67negative regulation of heart growth (GO:0061117)3.23821412
68negative regulation of cardiac muscle tissue growth (GO:0055022)3.23821412
69response to interferon-beta (GO:0035456)3.21002952
70positive regulation of protein homodimerization activity (GO:0090073)3.20276740
71oxidative phosphorylation (GO:0006119)3.19238116
72pseudouridine synthesis (GO:0001522)3.13888043
73negative regulation of T cell differentiation (GO:0045581)3.11038176
74adaptation of signaling pathway (GO:0023058)3.09667324
75negative regulation of T cell mediated immunity (GO:0002710)3.09288813
76positive regulation of type 2 immune response (GO:0002830)3.08804647
77glycine transport (GO:0015816)3.07899705
78mitochondrial respiratory chain complex assembly (GO:0033108)3.06359364
79postreplication repair (GO:0006301)3.05391489
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03818412
81positive regulation of T cell apoptotic process (GO:0070234)2.94925237
82cellular response to vitamin D (GO:0071305)2.94163504
83histone H2A ubiquitination (GO:0033522)2.93567603
84cullin deneddylation (GO:0010388)2.92824800
85regulation of alpha-beta T cell proliferation (GO:0046640)2.92533506
86preassembly of GPI anchor in ER membrane (GO:0016254)2.92087226
87plasma membrane repair (GO:0001778)2.89422491
88negative regulation of cardiac muscle hypertrophy (GO:0010614)2.87684301
89indole-containing compound metabolic process (GO:0042430)2.86949328
90negative regulation of heart rate (GO:0010459)2.86375906
91positive regulation of DNA repair (GO:0045739)2.82344817
92negative regulation of interleukin-17 production (GO:0032700)2.81666144
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80457308
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.80457308
95NADH dehydrogenase complex assembly (GO:0010257)2.80457308
96negative regulation of potassium ion transmembrane transport (GO:1901380)2.77795720
97pyrimidine nucleoside catabolic process (GO:0046135)2.77584425
98proline transport (GO:0015824)2.75053876
99positive regulation of DNA recombination (GO:0045911)2.74578293
100regulation of T-helper 2 cell differentiation (GO:0045628)2.72232694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.83287970
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.75239251
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.71223996
4ZNF274_21170338_ChIP-Seq_K562_Hela3.51592293
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.95294848
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71325773
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.31623731
8IGF1R_20145208_ChIP-Seq_DFB_Human2.31338218
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30639939
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22925624
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.21689413
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19603104
13GBX2_23144817_ChIP-Seq_PC3_Human2.18904555
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17178738
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09852809
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.06562544
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02073163
18E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98221478
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97010507
20CBP_20019798_ChIP-Seq_JUKART_Human1.91909050
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91909050
22EWS_26573619_Chip-Seq_HEK293_Human1.89117926
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78452587
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76311657
25MYC_18940864_ChIP-ChIP_HL60_Human1.75963334
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.74846150
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73438099
28AUTS2_25519132_ChIP-Seq_293T-REX_Human1.64372618
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64078155
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60694408
31ELK1_19687146_ChIP-ChIP_HELA_Human1.58334583
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56924761
33LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51479939
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47963756
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46987083
36AR_20517297_ChIP-Seq_VCAP_Human1.42452345
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41811195
38VDR_23849224_ChIP-Seq_CD4+_Human1.39223965
39HOXB7_26014856_ChIP-Seq_BT474_Human1.38852821
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38437750
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35029596
42GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.34735595
43GATA3_26560356_Chip-Seq_TH2_Human1.30555217
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27782475
45TAF15_26573619_Chip-Seq_HEK293_Human1.26251602
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26058660
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.26058660
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25624182
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25624182
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25624182
51ER_23166858_ChIP-Seq_MCF-7_Human1.24518283
52TP53_22573176_ChIP-Seq_HFKS_Human1.24485966
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24439897
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24390949
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24186412
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.23955993
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22546375
58FOXP3_21729870_ChIP-Seq_TREG_Human1.22003501
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21810059
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21532614
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20792064
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20608466
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20460164
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19668069
65NCOR_22424771_ChIP-Seq_293T_Human1.17593525
66TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15111046
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14766255
68SPI1_20517297_ChIP-Seq_HL60_Human1.13616542
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.11617569
70IRF1_19129219_ChIP-ChIP_H3396_Human1.09773715
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09098016
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.08977383
73P300_19829295_ChIP-Seq_ESCs_Human1.08198417
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07471230
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06028579
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05483097
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04089624
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.03827149
79SALL4_22934838_ChIP-ChIP_CD34+_Human1.03316036
80E2F7_22180533_ChIP-Seq_HELA_Human1.00938683
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.00803863
82AR_25329375_ChIP-Seq_VCAP_Human1.00203606
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97431507
84SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96866066
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96547682
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95458796
87NANOG_19829295_ChIP-Seq_ESCs_Human0.94929631
88SOX2_19829295_ChIP-Seq_ESCs_Human0.94929631
89P53_22387025_ChIP-Seq_ESCs_Mouse0.94336922
90HTT_18923047_ChIP-ChIP_STHdh_Human0.94309123
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92755328
92TAF2_19829295_ChIP-Seq_ESCs_Human0.92302405
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91963658
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.91494972
95GATA3_27048872_Chip-Seq_THYMUS_Human0.90014282
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89297889
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89034194
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87348913
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87054219
100CTCF_18555785_Chip-Seq_ESCs_Mouse0.86717469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.81632154
2MP0002102_abnormal_ear_morphology4.13469997
3MP0003950_abnormal_plasma_membrane3.80083265
4MP0006054_spinal_hemorrhage3.49072346
5MP0005671_abnormal_response_to3.17518553
6MP0004147_increased_porphyrin_level3.02935081
7MP0009780_abnormal_chondrocyte_physiolo2.86352518
8MP0003252_abnormal_bile_duct2.79569112
9MP0003806_abnormal_nucleotide_metabolis2.69754707
10MP0001835_abnormal_antigen_presentation2.66042348
11MP0001853_heart_inflammation2.26925486
12MP0009053_abnormal_anal_canal2.26437903
13MP0008775_abnormal_heart_ventricle2.25804437
14MP0008058_abnormal_DNA_repair2.23596285
15MP0005464_abnormal_platelet_physiology2.19295528
16MP0002653_abnormal_ependyma_morphology2.11891896
17MP0003724_increased_susceptibility_to2.10736920
18MP0001986_abnormal_taste_sensitivity2.05956402
19MP0008789_abnormal_olfactory_epithelium2.03374859
20MP0003866_abnormal_defecation1.96143413
21MP0004084_abnormal_cardiac_muscle1.92378982
22MP0001542_abnormal_bone_strength1.91124257
23MP0008872_abnormal_physiological_respon1.90839869
24MP0010234_abnormal_vibrissa_follicle1.90536040
25MP0005084_abnormal_gallbladder_morpholo1.82153470
26MP0010094_abnormal_chromosome_stability1.77766893
27MP0006072_abnormal_retinal_apoptosis1.76853904
28MP0004215_abnormal_myocardial_fiber1.76337912
29MP0002148_abnormal_hypersensitivity_rea1.75962271
30MP0003763_abnormal_thymus_physiology1.75939334
31MP0002006_tumorigenesis1.68651316
32MP0009785_altered_susceptibility_to1.58738970
33MP0005000_abnormal_immune_tolerance1.57287388
34MP0010155_abnormal_intestine_physiology1.47727236
35MP0004145_abnormal_muscle_electrophysio1.47298566
36MP0002166_altered_tumor_susceptibility1.46399788
37MP0005167_abnormal_blood-brain_barrier1.43463567
38MP0005394_taste/olfaction_phenotype1.42428592
39MP0005499_abnormal_olfactory_system1.42428592
40MP0005646_abnormal_pituitary_gland1.37374376
41MP0008877_abnormal_DNA_methylation1.36736153
42MP0003186_abnormal_redox_activity1.35329292
43MP0000230_abnormal_systemic_arterial1.34205898
44MP0000685_abnormal_immune_system1.31307466
45MP0000749_muscle_degeneration1.31170085
46MP0010329_abnormal_lipoprotein_level1.26906224
47MP0002837_dystrophic_cardiac_calcinosis1.24785972
48MP0003718_maternal_effect1.19964380
49MP0000467_abnormal_esophagus_morphology1.17995336
50MP0002452_abnormal_antigen_presenting1.16037627
51MP0004947_skin_inflammation1.10126246
52MP0002723_abnormal_immune_serum1.06385983
53MP0001486_abnormal_startle_reflex0.98064513
54MP0001800_abnormal_humoral_immune0.97725127
55MP0002127_abnormal_cardiovascular_syste0.97671050
56MP0005083_abnormal_biliary_tract0.97272491
57MP0000689_abnormal_spleen_morphology0.96689016
58MP0005423_abnormal_somatic_nervous0.95359783
59MP0002398_abnormal_bone_marrow0.94083549
60MP0009764_decreased_sensitivity_to0.91160615
61MP0005636_abnormal_mineral_homeostasis0.90296985
62MP0005085_abnormal_gallbladder_physiolo0.89892903
63MP0002928_abnormal_bile_duct0.89252873
64MP0001819_abnormal_immune_cell0.87859013
65MP0003011_delayed_dark_adaptation0.85480469
66MP0002420_abnormal_adaptive_immunity0.83149276
67MP0001765_abnormal_ion_homeostasis0.83114699
68MP0004381_abnormal_hair_follicle0.81355364
69MP0009763_increased_sensitivity_to0.80579558
70MP0001533_abnormal_skeleton_physiology0.79804664
71MP0008004_abnormal_stomach_pH0.79609924
72MP0001529_abnormal_vocalization0.78308057
73MP0005171_absent_coat_pigmentation0.77375632
74MP0003045_fibrosis0.76953208
75MP0005330_cardiomyopathy0.76458714
76MP0000490_abnormal_crypts_of0.75495269
77MP0003656_abnormal_erythrocyte_physiolo0.74586408
78MP0005165_increased_susceptibility_to0.72973850
79MP0000343_altered_response_to0.72577191
80MP0003436_decreased_susceptibility_to0.69625000
81MP0005253_abnormal_eye_physiology0.69544107
82MP0000703_abnormal_thymus_morphology0.68814277
83MP0004782_abnormal_surfactant_physiolog0.66685832
84MP0000427_abnormal_hair_cycle0.65001770
85MP0000858_altered_metastatic_potential0.64804743
86MP0003828_pulmonary_edema0.64705802
87MP0005623_abnormal_meninges_morphology0.64160816
88MP0001845_abnormal_inflammatory_respons0.63686467
89MP0001790_abnormal_immune_system0.63387866
90MP0005387_immune_system_phenotype0.63387866
91MP0001661_extended_life_span0.62464628
92MP0005319_abnormal_enzyme/_coenzyme0.62098073
93MP0005647_abnormal_sex_gland0.61064207
94MP0005220_abnormal_exocrine_pancreas0.60284236
95MP0003137_abnormal_impulse_conducting0.59924539
96MP0003448_altered_tumor_morphology0.59763083
97MP0002736_abnormal_nociception_after0.59722728
98MP0000716_abnormal_immune_system0.59449072
99MP0009765_abnormal_xenobiotic_induced0.58593859
100MP0002019_abnormal_tumor_incidence0.58146647

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.47571043
2Petechiae (HP:0000967)5.12150057
3Methylmalonic acidemia (HP:0002912)4.82417863
4Aplastic anemia (HP:0001915)4.13259134
5Renal cortical cysts (HP:0000803)3.87997117
6Purpura (HP:0000979)3.72157237
7Abnormality of alanine metabolism (HP:0010916)3.69726682
8Hyperalaninemia (HP:0003348)3.69726682
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.69726682
10Prolonged bleeding time (HP:0003010)3.49376047
11Subaortic stenosis (HP:0001682)3.35919637
12Abnormality of the left ventricular outflow tract (HP:0011103)3.35919637
13Abnormality of the vitamin B12 metabolism (HP:0004341)3.19585188
14Methylmalonic aciduria (HP:0012120)3.15966168
15Calf muscle hypertrophy (HP:0008981)3.15435278
16Hepatosplenomegaly (HP:0001433)3.08605511
17Tubulointerstitial fibrosis (HP:0005576)2.96577175
18Abnormality of the proximal phalanges of the hand (HP:0009834)2.96530907
19Abnormality of vitamin B metabolism (HP:0004340)2.93973725
20Thyroiditis (HP:0100646)2.86828670
21Hepatic necrosis (HP:0002605)2.80839074
22Abnormality of the renal cortex (HP:0011035)2.80479282
23Hepatocellular necrosis (HP:0001404)2.79516335
24Exercise-induced muscle cramps (HP:0003710)2.79338756
25Muscle hypertrophy of the lower extremities (HP:0008968)2.77672768
26Severe combined immunodeficiency (HP:0004430)2.75228415
27Exercise-induced myalgia (HP:0003738)2.67434146
28Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.65916479
29Prolonged neonatal jaundice (HP:0006579)2.63975357
30Pigmentary retinal degeneration (HP:0001146)2.55274286
31Anomalous pulmonary venous return (HP:0010772)2.54058303
32Increased serum lactate (HP:0002151)2.49190215
33Hemiparesis (HP:0001269)2.47871009
34Mitochondrial inheritance (HP:0001427)2.45512189
35Testicular atrophy (HP:0000029)2.43382864
36Abnormality of the phalanges of the 5th finger (HP:0004213)2.40231866
37Hypoplasia of the uterus (HP:0000013)2.38049196
38Fibular aplasia (HP:0002990)2.38041533
39Myotonia (HP:0002486)2.37684707
40Hypoplasia of the fovea (HP:0007750)2.37139211
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.37139211
42Poor head control (HP:0002421)2.33397747
43Abnormality of the ileum (HP:0001549)2.32951874
44Cleft eyelid (HP:0000625)2.32694572
45Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32331021
46Symphalangism affecting the phalanges of the hand (HP:0009773)2.31230797
47Pancreatic cysts (HP:0001737)2.27724461
48Hyperglycinuria (HP:0003108)2.27112195
49Abnormality of the pulmonary veins (HP:0011718)2.26361015
50Type 2 muscle fiber atrophy (HP:0003554)2.25379652
51Sudden death (HP:0001699)2.22687826
52Systemic lupus erythematosus (HP:0002725)2.22677768
53Abnormality of the middle phalanges of the toes (HP:0010183)2.21577526
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.21335812
55Combined immunodeficiency (HP:0005387)2.21335703
56Palpebral edema (HP:0100540)2.20113210
57Meckel diverticulum (HP:0002245)2.18190958
58Porencephaly (HP:0002132)2.16412400
59Increased CSF lactate (HP:0002490)2.15886388
60Dyschromatopsia (HP:0007641)2.15173201
61Abnormality of proline metabolism (HP:0010907)2.14619067
62Hydroxyprolinuria (HP:0003080)2.14619067
63Abnormality of the carotid arteries (HP:0005344)2.12230291
64Basal ganglia calcification (HP:0002135)2.10451403
65Clubbing of toes (HP:0100760)2.10208014
66Increased hepatocellular lipid droplets (HP:0006565)2.08140967
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07547706
68Renal Fanconi syndrome (HP:0001994)2.07387023
69Tubulointerstitial abnormality (HP:0001969)2.03557857
70Lipid accumulation in hepatocytes (HP:0006561)2.03050134
71Adactyly (HP:0009776)2.01478890
72Tetraparesis (HP:0002273)1.98810602
73Curly hair (HP:0002212)1.94664284
74IgG deficiency (HP:0004315)1.93749335
75Abnormality of glycine metabolism (HP:0010895)1.93270398
76Abnormality of serine family amino acid metabolism (HP:0010894)1.93270398
77Dynein arm defect of respiratory motile cilia (HP:0012255)1.92898666
78Absent/shortened dynein arms (HP:0200106)1.92898666
79Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.90730760
80Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.89712795
81Pancreatic fibrosis (HP:0100732)1.89488801
82Hemorrhage of the eye (HP:0011885)1.88798503
83Abnormality of vitamin metabolism (HP:0100508)1.88016172
84Increased intramyocellular lipid droplets (HP:0012240)1.86545117
85Abnormality of the fovea (HP:0000493)1.83693620
86Lower limb hyperreflexia (HP:0002395)1.83176861
87Menorrhagia (HP:0000132)1.81646981
88Hypoplasia of the thymus (HP:0000778)1.80248926
89Congenital, generalized hypertrichosis (HP:0004540)1.79605876
90Autoimmune hemolytic anemia (HP:0001890)1.79447627
91Periorbital edema (HP:0100539)1.79346934
92Abnormality of the preputium (HP:0100587)1.78764701
93T lymphocytopenia (HP:0005403)1.78354204
94Aplasia/hypoplasia of the uterus (HP:0008684)1.78134767
95Abnormality of transition element cation homeostasis (HP:0011030)1.75859085
96Conical tooth (HP:0000698)1.75354023
97Abnormality of B cell number (HP:0010975)1.75310153
98Asplenia (HP:0001746)1.75145819
99Epistaxis (HP:0000421)1.74757915
100Muscle fiber atrophy (HP:0100295)1.72877784

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.30469348
2TXK3.72713795
3EIF2AK13.72017345
4TLK13.40746107
5EIF2AK33.08207474
6CDK83.00078459
7ZAK2.95147397
8FRK2.94167791
9NUAK12.33750916
10VRK22.13914861
11MAPKAPK52.05423789
12GRK71.99019427
13MAP3K141.91193392
14TAOK31.81264477
15MUSK1.74088542
16EIF2AK21.71640352
17TESK21.67207895
18KDR1.67094357
19EPHA31.65804397
20GRK51.59963452
21CCNB11.57147633
22PAK61.47762986
23SYK1.45763910
24MOS1.38473215
25KIT1.31299733
26RPS6KA41.29936991
27BUB11.26345077
28MYLK1.24791530
29IKBKB1.22678704
30BMPR1B1.19071727
31MAP4K11.17678920
32VRK11.16396346
33PLK31.12522131
34MAP4K21.10078850
35DMPK1.09784353
36STK101.09699535
37TGFBR21.09436063
38TEC1.07739064
39PIK3CA1.02147490
40GRK11.00382446
41TGFBR10.98790746
42BTK0.98308231
43JAK10.91328128
44ATR0.88703946
45WNK30.86909031
46ZAP700.86736343
47ACVR1B0.84797064
48DAPK20.79978171
49PHKG10.78454081
50PHKG20.78454081
51RPS6KA50.77314289
52LYN0.75983708
53SRPK10.73704340
54PIK3CG0.72528668
55CHUK0.70801013
56CSF1R0.70157582
57FLT30.68169901
58ILK0.68050387
59PASK0.67640768
60RIPK40.66762977
61STK160.62371037
62PRKCQ0.62310267
63ADRBK20.61551516
64LCK0.58541351
65PTK2B0.58493753
66TNK20.57520158
67TIE10.55648770
68INSRR0.54339418
69PLK20.53514686
70NEK10.51733062
71GRK60.51481612
72MKNK10.50619841
73TBK10.48644486
74CDK90.48369842
75HCK0.46718593
76STK38L0.46235218
77ADRBK10.45703515
78PRKACB0.45218870
79JAK20.44475091
80PRKCI0.44341312
81FGFR20.41119689
82ITK0.39591744
83ABL10.38894145
84MAP2K20.38469215
85ABL20.35464491
86CDC70.33217587
87PAK10.31816011
88TYK20.31800368
89WNK40.30645136
90CDK60.30341634
91STK240.29354328
92IKBKE0.28968348
93PRKCE0.28931055
94CSNK1D0.26630436
95PLK10.26246091
96IGF1R0.26180429
97SCYL20.26090817
98HIPK20.24520668
99TSSK60.24327004
100CDK40.23836562

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.17525960
2Graft-versus-host disease_Homo sapiens_hsa053322.08964295
3Antigen processing and presentation_Homo sapiens_hsa046122.07432101
4Caffeine metabolism_Homo sapiens_hsa0023211.2445059
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92713633
6Tryptophan metabolism_Homo sapiens_hsa003801.91503975
7Drug metabolism - other enzymes_Homo sapiens_hsa009831.89429241
8Proteasome_Homo sapiens_hsa030501.86547473
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81085255
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74664274
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70902960
12Mismatch repair_Homo sapiens_hsa034301.66225797
13Oxidative phosphorylation_Homo sapiens_hsa001901.57333621
14Protein export_Homo sapiens_hsa030601.52321207
15Asthma_Homo sapiens_hsa053101.49544794
16Primary immunodeficiency_Homo sapiens_hsa053401.49261491
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.48410001
18Fanconi anemia pathway_Homo sapiens_hsa034601.43151078
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38862978
20Propanoate metabolism_Homo sapiens_hsa006401.34636753
21RNA polymerase_Homo sapiens_hsa030201.28028035
22Parkinsons disease_Homo sapiens_hsa050121.22710019
23Linoleic acid metabolism_Homo sapiens_hsa005911.19715101
24One carbon pool by folate_Homo sapiens_hsa006701.15597991
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14994695
26Allograft rejection_Homo sapiens_hsa053301.13059305
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11424361
28Chemical carcinogenesis_Homo sapiens_hsa052041.10834432
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03912393
30Autoimmune thyroid disease_Homo sapiens_hsa053201.03183036
31Arachidonic acid metabolism_Homo sapiens_hsa005900.97246102
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96858170
33Phototransduction_Homo sapiens_hsa047440.96415512
34Non-homologous end-joining_Homo sapiens_hsa034500.94116314
35Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93503658
36Lysine degradation_Homo sapiens_hsa003100.88628038
37Olfactory transduction_Homo sapiens_hsa047400.88426856
38beta-Alanine metabolism_Homo sapiens_hsa004100.87349208
39Homologous recombination_Homo sapiens_hsa034400.86949513
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85844507
41Type I diabetes mellitus_Homo sapiens_hsa049400.84993650
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.82792664
43Legionellosis_Homo sapiens_hsa051340.80595591
44Systemic lupus erythematosus_Homo sapiens_hsa053220.79177528
45Hematopoietic cell lineage_Homo sapiens_hsa046400.78769547
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77582372
47Spliceosome_Homo sapiens_hsa030400.76419461
48Alzheimers disease_Homo sapiens_hsa050100.72742238
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72557755
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71351335
51Cardiac muscle contraction_Homo sapiens_hsa042600.69265388
52Platelet activation_Homo sapiens_hsa046110.68426643
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66501930
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61722216
55RNA degradation_Homo sapiens_hsa030180.61597886
56DNA replication_Homo sapiens_hsa030300.60648685
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59314914
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59057994
59Malaria_Homo sapiens_hsa051440.53300087
60Serotonergic synapse_Homo sapiens_hsa047260.52259244
61B cell receptor signaling pathway_Homo sapiens_hsa046620.51729735
62Huntingtons disease_Homo sapiens_hsa050160.48987676
63Pyrimidine metabolism_Homo sapiens_hsa002400.48929674
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48627514
65Regulation of autophagy_Homo sapiens_hsa041400.45829432
66Viral myocarditis_Homo sapiens_hsa054160.44568626
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43839423
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42803290
69Glycerolipid metabolism_Homo sapiens_hsa005610.42658713
70Purine metabolism_Homo sapiens_hsa002300.42478755
71Rheumatoid arthritis_Homo sapiens_hsa053230.39442710
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.37536858
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36082675
74Retinol metabolism_Homo sapiens_hsa008300.34171036
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33533259
76GABAergic synapse_Homo sapiens_hsa047270.30712714
77Renin secretion_Homo sapiens_hsa049240.29324637
78Histidine metabolism_Homo sapiens_hsa003400.29138565
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27123078
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27056955
81Metabolic pathways_Homo sapiens_hsa011000.26910521
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26312237
83Taste transduction_Homo sapiens_hsa047420.26051884
84Alcoholism_Homo sapiens_hsa050340.25231049
85T cell receptor signaling pathway_Homo sapiens_hsa046600.24258386
86Pancreatic secretion_Homo sapiens_hsa049720.23871160
87Ribosome_Homo sapiens_hsa030100.23480868
88Nucleotide excision repair_Homo sapiens_hsa034200.23115389
89Morphine addiction_Homo sapiens_hsa050320.22441259
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.22429534
91Staphylococcus aureus infection_Homo sapiens_hsa051500.22370349
92Pyruvate metabolism_Homo sapiens_hsa006200.22363829
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.21760777
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21238580
95Shigellosis_Homo sapiens_hsa051310.20726372
96Herpes simplex infection_Homo sapiens_hsa051680.19324928
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.17017791
98RNA transport_Homo sapiens_hsa030130.15631341
99Leishmaniasis_Homo sapiens_hsa051400.15182742
100Chemokine signaling pathway_Homo sapiens_hsa040620.14800762

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