TMA16P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kynurenine metabolic process (GO:0070189)7.72899847
2indole-containing compound catabolic process (GO:0042436)7.25112370
3indolalkylamine catabolic process (GO:0046218)7.25112370
4tryptophan catabolic process (GO:0006569)7.25112370
5tryptophan metabolic process (GO:0006568)6.79045862
6negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.97560633
7cell wall macromolecule catabolic process (GO:0016998)5.64052757
8positive regulation of T cell differentiation in thymus (GO:0033089)5.61597177
9DNA deamination (GO:0045006)5.54287401
10indolalkylamine metabolic process (GO:0006586)5.19464132
11negative regulation of DNA-templated transcription, elongation (GO:0032785)4.85826773
12cytochrome complex assembly (GO:0017004)4.69512486
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.69052965
14cell wall macromolecule metabolic process (GO:0044036)4.68617406
15preassembly of GPI anchor in ER membrane (GO:0016254)4.68522709
16adaptation of signaling pathway (GO:0023058)4.66542321
17regulation of regulatory T cell differentiation (GO:0045589)4.60087067
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.49658737
19protein polyglutamylation (GO:0018095)4.47314569
20histone H2A ubiquitination (GO:0033522)4.38057530
21regulation of memory T cell differentiation (GO:0043380)4.35987743
22respiratory chain complex IV assembly (GO:0008535)4.31427889
23cellular biogenic amine catabolic process (GO:0042402)4.22993372
24amine catabolic process (GO:0009310)4.22993372
25cytidine deamination (GO:0009972)4.07587061
26cytidine metabolic process (GO:0046087)4.07587061
27cytidine catabolic process (GO:0006216)4.07587061
28somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.06518163
29isotype switching (GO:0045190)4.06518163
30somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.06518163
31regulation of T cell differentiation in thymus (GO:0033081)4.00879187
32NAD biosynthetic process (GO:0009435)3.96115300
33negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.91157100
34negative regulation of T-helper cell differentiation (GO:0045623)3.91157100
35indole-containing compound metabolic process (GO:0042430)3.85575499
36regulation of immunoglobulin secretion (GO:0051023)3.82776868
37kidney morphogenesis (GO:0060993)3.81277510
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80502199
39DNA double-strand break processing (GO:0000729)3.79326208
40negative regulation of T cell differentiation in thymus (GO:0033085)3.75412651
41cullin deneddylation (GO:0010388)3.73747966
42snRNA transcription (GO:0009301)3.72731258
43maturation of 5.8S rRNA (GO:0000460)3.71934645
44positive regulation of T cell cytokine production (GO:0002726)3.71211401
45benzene-containing compound metabolic process (GO:0042537)3.64982608
46DNA demethylation (GO:0080111)3.59692944
47non-recombinational repair (GO:0000726)3.58558466
48double-strand break repair via nonhomologous end joining (GO:0006303)3.58558466
49aromatic amino acid family catabolic process (GO:0009074)3.50558174
50iron ion import (GO:0097286)3.48178410
51pseudouridine synthesis (GO:0001522)3.46848659
52protein complex biogenesis (GO:0070271)3.45892885
53DNA catabolic process, exonucleolytic (GO:0000738)3.41307942
54negative regulation of alpha-beta T cell differentiation (GO:0046639)3.39936219
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.39697388
56oxidative phosphorylation (GO:0006119)3.38260234
57negative regulation of T cell mediated immunity (GO:0002710)3.35595132
58protein deneddylation (GO:0000338)3.35439481
59cellular response to interferon-beta (GO:0035458)3.34172472
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32583150
61regulation of mitotic spindle checkpoint (GO:1903504)3.32583150
62GPI anchor metabolic process (GO:0006505)3.27975000
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.27770914
64positive regulation of DNA repair (GO:0045739)3.24374939
65interferon-gamma production (GO:0032609)3.24154125
66piRNA metabolic process (GO:0034587)3.23405664
67response to gravity (GO:0009629)3.17617179
68regulation of T-helper 1 cell differentiation (GO:0045625)3.17543716
69copper ion transport (GO:0006825)3.11678836
70mitochondrial respiratory chain complex assembly (GO:0033108)3.09809269
71positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03605082
72negative regulation of T cell differentiation (GO:0045581)2.99562184
73GPI anchor biosynthetic process (GO:0006506)2.99233845
74ovulation cycle (GO:0042698)2.97134751
75response to interferon-beta (GO:0035456)2.97020992
76pyridine nucleotide biosynthetic process (GO:0019363)2.94453982
77nicotinamide nucleotide biosynthetic process (GO:0019359)2.94453982
78phosphatidylinositol acyl-chain remodeling (GO:0036149)2.93028445
79response to growth hormone (GO:0060416)2.91967131
80negative T cell selection (GO:0043383)2.91091516
81histone H2A monoubiquitination (GO:0035518)2.90602364
82negative regulation of mRNA processing (GO:0050686)2.90139245
83synapsis (GO:0007129)2.89309170
84regulation of T cell cytokine production (GO:0002724)2.88041597
85dicarboxylic acid biosynthetic process (GO:0043650)2.87797908
86positive T cell selection (GO:0043368)2.83776158
87B cell activation involved in immune response (GO:0002312)2.81543546
88regulation of thymocyte apoptotic process (GO:0070243)2.80343373
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80044817
90mitochondrial respiratory chain complex I assembly (GO:0032981)2.80044817
91NADH dehydrogenase complex assembly (GO:0010257)2.80044817
92aromatic amino acid family metabolic process (GO:0009072)2.79466567
93lysine catabolic process (GO:0006554)2.76912435
94lysine metabolic process (GO:0006553)2.76912435
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73626812
96regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.70324446
97maturation of SSU-rRNA (GO:0030490)2.68393952
98replication fork processing (GO:0031297)2.67592892
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67537353
100somite development (GO:0061053)2.67279439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.12647541
2ZNF274_21170338_ChIP-Seq_K562_Hela3.29969314
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18063511
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.13229031
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03704601
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03315633
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03116954
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69612674
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.40072263
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30083771
11VDR_22108803_ChIP-Seq_LS180_Human2.23248503
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16901746
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16262765
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11596917
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10709334
16VDR_23849224_ChIP-Seq_CD4+_Human2.08338811
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.06104813
18GBX2_23144817_ChIP-Seq_PC3_Human2.05478151
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.04832655
20CBP_20019798_ChIP-Seq_JUKART_Human2.04832655
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02395346
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01717733
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00612660
24E2F7_22180533_ChIP-Seq_HELA_Human1.93489984
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91185612
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83116778
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.82013903
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79910700
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78646303
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70013935
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.68672313
32EWS_26573619_Chip-Seq_HEK293_Human1.68321162
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66166883
34MYC_18940864_ChIP-ChIP_HL60_Human1.65908233
35FOXP3_21729870_ChIP-Seq_TREG_Human1.65574279
36ER_23166858_ChIP-Seq_MCF-7_Human1.64447905
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.56373798
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.56373798
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55450412
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54751298
41IGF1R_20145208_ChIP-Seq_DFB_Human1.50503024
42ELK1_19687146_ChIP-ChIP_HELA_Human1.49895103
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.49412650
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48716002
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47243640
46AR_20517297_ChIP-Seq_VCAP_Human1.47236054
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.46691889
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.45023672
49LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39971423
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39695384
51IRF1_19129219_ChIP-ChIP_H3396_Human1.38845997
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33719863
53TP53_22573176_ChIP-Seq_HFKS_Human1.32657291
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32059838
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.30069150
56P300_19829295_ChIP-Seq_ESCs_Human1.29701853
57HOXB7_26014856_ChIP-Seq_BT474_Human1.28904266
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25725236
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21331176
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.21253776
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18506925
62GATA3_26560356_Chip-Seq_TH2_Human1.17610441
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17475798
64TCF4_22108803_ChIP-Seq_LS180_Human1.15228782
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.13759220
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12626661
67NANOG_19829295_ChIP-Seq_ESCs_Human1.12345690
68SOX2_19829295_ChIP-Seq_ESCs_Human1.12345690
69NCOR_22424771_ChIP-Seq_293T_Human1.12095054
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11876847
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10588386
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10271953
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06477729
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05637902
75TAF15_26573619_Chip-Seq_HEK293_Human1.04346686
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04206272
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03149287
78BCAT_22108803_ChIP-Seq_LS180_Human1.02591018
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01889169
80GATA3_26560356_Chip-Seq_TH1_Human1.00707111
81ELF5_23300383_ChIP-Seq_T47D_Human1.00389058
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.00116141
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00005644
84STAT3_18555785_Chip-Seq_ESCs_Mouse0.99021502
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98953994
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98741688
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98406463
88CTCF_18555785_Chip-Seq_ESCs_Mouse0.97800802
89MYB_26560356_Chip-Seq_TH2_Human0.97613514
90CDX2_22108803_ChIP-Seq_LS180_Human0.96875512
91AR_25329375_ChIP-Seq_VCAP_Human0.96870329
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96258929
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94282534
94SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93936231
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.93457580
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92464017
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92460176
98P53_22387025_ChIP-Seq_ESCs_Mouse0.92170272
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91199411
100GABP_19822575_ChIP-Seq_HepG2_Human0.90319113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.31626179
2MP0008875_abnormal_xenobiotic_pharmacok4.75905446
3MP0001853_heart_inflammation3.06948816
4MP0006054_spinal_hemorrhage3.02501159
5MP0005671_abnormal_response_to2.82665205
6MP0003646_muscle_fatigue2.70047406
7MP0001835_abnormal_antigen_presentation2.51220535
8MP0001986_abnormal_taste_sensitivity2.47787278
9MP0006072_abnormal_retinal_apoptosis2.38305490
10MP0008877_abnormal_DNA_methylation2.33643329
11MP0002837_dystrophic_cardiac_calcinosis2.24966113
12MP0003252_abnormal_bile_duct2.24844352
13MP0003806_abnormal_nucleotide_metabolis2.24521564
14MP0005167_abnormal_blood-brain_barrier2.12618437
15MP0003866_abnormal_defecation2.09409049
16MP0008058_abnormal_DNA_repair2.04697319
17MP0005423_abnormal_somatic_nervous2.04455998
18MP0002653_abnormal_ependyma_morphology2.01974170
19MP0009053_abnormal_anal_canal1.99552653
20MP0009780_abnormal_chondrocyte_physiolo1.95966707
21MP0010094_abnormal_chromosome_stability1.93173759
22MP0002006_tumorigenesis1.81651805
23MP0008789_abnormal_olfactory_epithelium1.77279672
24MP0008775_abnormal_heart_ventricle1.74291077
25MP0004145_abnormal_muscle_electrophysio1.73972906
26MP0006292_abnormal_olfactory_placode1.72819998
27MP0002148_abnormal_hypersensitivity_rea1.66714188
28MP0003763_abnormal_thymus_physiology1.66381081
29MP0003656_abnormal_erythrocyte_physiolo1.65597905
30MP0003011_delayed_dark_adaptation1.65521403
31MP0003718_maternal_effect1.57271668
32MP0005360_urolithiasis1.52109172
33MP0005646_abnormal_pituitary_gland1.51261842
34MP0002166_altered_tumor_susceptibility1.51024287
35MP0001542_abnormal_bone_strength1.49980890
36MP0000537_abnormal_urethra_morphology1.45801544
37MP0005253_abnormal_eye_physiology1.43526980
38MP0005000_abnormal_immune_tolerance1.37011217
39MP0004381_abnormal_hair_follicle1.34674344
40MP0005636_abnormal_mineral_homeostasis1.32957020
41MP0005551_abnormal_eye_electrophysiolog1.31600739
42MP0003186_abnormal_redox_activity1.26096561
43MP0009785_altered_susceptibility_to1.23130411
44MP0009764_decreased_sensitivity_to1.22935300
45MP0001984_abnormal_olfaction1.21231869
46MP0010329_abnormal_lipoprotein_level1.15558472
47MP0008872_abnormal_physiological_respon1.11577893
48MP0002452_abnormal_antigen_presenting1.09429064
49MP0002736_abnormal_nociception_after1.07906426
50MP0004215_abnormal_myocardial_fiber1.07857233
51MP0000372_irregular_coat_pigmentation1.06397772
52MP0005394_taste/olfaction_phenotype1.04783575
53MP0005499_abnormal_olfactory_system1.04783575
54MP0000427_abnormal_hair_cycle1.03267485
55MP0001800_abnormal_humoral_immune1.02277322
56MP0004947_skin_inflammation1.00372033
57MP0002723_abnormal_immune_serum1.00094359
58MP0004185_abnormal_adipocyte_glucose0.97804789
59MP0001819_abnormal_immune_cell0.95488123
60MP0002277_abnormal_respiratory_mucosa0.94432509
61MP0002234_abnormal_pharynx_morphology0.93749053
62MP0004782_abnormal_surfactant_physiolog0.93487277
63MP0000689_abnormal_spleen_morphology0.92682360
64MP0005647_abnormal_sex_gland0.91897038
65MP0005220_abnormal_exocrine_pancreas0.91537778
66MP0002420_abnormal_adaptive_immunity0.91128823
67MP0005085_abnormal_gallbladder_physiolo0.90880373
68MP0002127_abnormal_cardiovascular_syste0.90845176
69MP0010155_abnormal_intestine_physiology0.89114584
70MP0002398_abnormal_bone_marrow0.87537426
71MP0002638_abnormal_pupillary_reflex0.85844020
72MP0003045_fibrosis0.85651799
73MP0009765_abnormal_xenobiotic_induced0.80944667
74MP0000685_abnormal_immune_system0.76879139
75MP0000383_abnormal_hair_follicle0.76388647
76MP0002876_abnormal_thyroid_physiology0.75473224
77MP0002928_abnormal_bile_duct0.74365932
78MP0001765_abnormal_ion_homeostasis0.73960830
79MP0005332_abnormal_amino_acid0.72968550
80MP0002693_abnormal_pancreas_physiology0.72102074
81MP0002102_abnormal_ear_morphology0.70379495
82MP0004142_abnormal_muscle_tone0.69660817
83MP0000230_abnormal_systemic_arterial0.66344033
84MP0001501_abnormal_sleep_pattern0.65992042
85MP0010678_abnormal_skin_adnexa0.65346981
86MP0001486_abnormal_startle_reflex0.65323957
87MP0005389_reproductive_system_phenotype0.63668429
88MP0005084_abnormal_gallbladder_morpholo0.63582426
89MP0001968_abnormal_touch/_nociception0.62198700
90MP0002419_abnormal_innate_immunity0.61453096
91MP0000703_abnormal_thymus_morphology0.61185240
92MP0004085_abnormal_heartbeat0.60146901
93MP0000716_abnormal_immune_system0.60109725
94MP0003868_abnormal_feces_composition0.58319988
95MP0005171_absent_coat_pigmentation0.57651773
96MP0005645_abnormal_hypothalamus_physiol0.57627775
97MP0002138_abnormal_hepatobiliary_system0.56901362
98MP0000631_abnormal_neuroendocrine_gland0.55884301
99MP0001845_abnormal_inflammatory_respons0.55200926
100MP0001790_abnormal_immune_system0.54969274

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.09368094
2Methylmalonic acidemia (HP:0002912)4.78446449
3Abnormality of the proximal phalanges of the hand (HP:0009834)3.81100034
4Pancreatic cysts (HP:0001737)3.66828846
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.65908198
6Abnormality of alanine metabolism (HP:0010916)3.65908198
7Hyperalaninemia (HP:0003348)3.65908198
8Methylmalonic aciduria (HP:0012120)3.50343172
9Aplastic anemia (HP:0001915)3.24067700
10Severe combined immunodeficiency (HP:0004430)3.23289171
11True hermaphroditism (HP:0010459)3.15531847
12Duplicated collecting system (HP:0000081)3.14297229
13Adactyly (HP:0009776)3.10896475
14Abnormality of the middle phalanges of the toes (HP:0010183)3.08755150
15Abnormality of the vitamin B12 metabolism (HP:0004341)3.07519083
16Abnormality of the renal collecting system (HP:0004742)3.07054751
17Abnormality of the phalanges of the 2nd finger (HP:0009541)3.05177562
18Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.05084121
19Fibular aplasia (HP:0002990)3.00180702
20Clubbing of toes (HP:0100760)2.99557674
21Abnormality of the ileum (HP:0001549)2.91332611
22Thyroiditis (HP:0100646)2.86053859
23Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.85224030
24Abnormality of vitamin B metabolism (HP:0004340)2.83826643
25Meckel diverticulum (HP:0002245)2.81042593
26Pancreatic fibrosis (HP:0100732)2.80393387
27Abnormality of the phalanges of the 5th finger (HP:0004213)2.76393162
28Renal cortical cysts (HP:0000803)2.74266790
29Hemiparesis (HP:0001269)2.71578213
30Increased hepatocellular lipid droplets (HP:0006565)2.70138158
31Lipid accumulation in hepatocytes (HP:0006561)2.66422021
32Increased serum lactate (HP:0002151)2.65947842
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.64814945
34Large for gestational age (HP:0001520)2.62747899
35Hyperglycinuria (HP:0003108)2.61923403
36Hepatocellular necrosis (HP:0001404)2.61874203
37Combined immunodeficiency (HP:0005387)2.58274382
38Hypoplasia of the uterus (HP:0000013)2.56978175
39Mitochondrial inheritance (HP:0001427)2.56742275
40Testicular atrophy (HP:0000029)2.51991119
41Abnormality of the carotid arteries (HP:0005344)2.51279490
42Hepatic necrosis (HP:0002605)2.47065864
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42586240
44Pigmentary retinal degeneration (HP:0001146)2.41891213
45IgG deficiency (HP:0004315)2.40119048
46Increased CSF lactate (HP:0002490)2.39492710
47Nephronophthisis (HP:0000090)2.35998388
48Symphalangism affecting the phalanges of the hand (HP:0009773)2.35105671
49Poor head control (HP:0002421)2.25050097
50Anomalous pulmonary venous return (HP:0010772)2.23298577
51Abnormality of the preputium (HP:0100587)2.22860553
52Aplasia/hypoplasia of the uterus (HP:0008684)2.21977883
53Spastic paraparesis (HP:0002313)2.19360203
54Short hallux (HP:0010109)2.18089685
55Pheochromocytoma (HP:0002666)2.15227067
56Tubulointerstitial fibrosis (HP:0005576)2.13835833
57Abnormality of glycine metabolism (HP:0010895)2.12225205
58Abnormality of serine family amino acid metabolism (HP:0010894)2.12225205
59Porencephaly (HP:0002132)2.11447540
60Cleft eyelid (HP:0000625)2.10784716
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10090401
62Cystic liver disease (HP:0006706)2.06997950
63Abnormal rod and cone electroretinograms (HP:0008323)2.05883460
64Abnormality of the renal cortex (HP:0011035)2.03738253
65Renal Fanconi syndrome (HP:0001994)2.03287544
66Tetraparesis (HP:0002273)1.99543594
67Abnormality of vitamin metabolism (HP:0100508)1.99227858
68Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98038475
69Petechiae (HP:0000967)1.97586770
70Aplasia/Hypoplasia of the hallux (HP:0008362)1.95998487
71Progressive microcephaly (HP:0000253)1.95944756
72Posterior subcapsular cataract (HP:0007787)1.94197466
73Prolonged neonatal jaundice (HP:0006579)1.94117546
74Neuroendocrine neoplasm (HP:0100634)1.92311722
75Increased intramyocellular lipid droplets (HP:0012240)1.92201413
76Neurodegeneration (HP:0002180)1.91587107
77Neoplasm of the adrenal gland (HP:0100631)1.91253981
78Absent/shortened dynein arms (HP:0200106)1.89500543
79Dynein arm defect of respiratory motile cilia (HP:0012255)1.89500543
80Abnormality of the pulmonary veins (HP:0011718)1.88702325
81Abolished electroretinogram (ERG) (HP:0000550)1.87585240
82Exertional dyspnea (HP:0002875)1.86996806
83Stomach cancer (HP:0012126)1.85919865
84Abnormality of proline metabolism (HP:0010907)1.85735674
85Hydroxyprolinuria (HP:0003080)1.85735674
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85676421
87Congenital, generalized hypertrichosis (HP:0004540)1.84957390
88Dysdiadochokinesis (HP:0002075)1.83641486
89Abnormality of chromosome stability (HP:0003220)1.82750260
90Ketoacidosis (HP:0001993)1.82415018
91T lymphocytopenia (HP:0005403)1.80032615
92Acute necrotizing encephalopathy (HP:0006965)1.79886612
93Abnormality of the diencephalon (HP:0010662)1.78784075
94Abnormality of the renal medulla (HP:0100957)1.78601984
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78050551
96Dicarboxylic aciduria (HP:0003215)1.78050551
97Molar tooth sign on MRI (HP:0002419)1.76986350
98Abnormality of midbrain morphology (HP:0002418)1.76986350
99Medial flaring of the eyebrow (HP:0010747)1.76557065
100Small intestinal stenosis (HP:0012848)1.76218724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.59412716
2MST43.77902912
3EIF2AK13.66068191
4FRK3.36793702
5GRK73.33716043
6TGFBR22.91249450
7NUAK12.82644702
8TLK12.62552812
9MOS2.60497167
10ZAK2.60296778
11EIF2AK32.57450960
12EPHA32.47569603
13STK102.26039348
14EIF2AK22.17510989
15VRK21.87220882
16MAP4K21.77847984
17GRK51.67928430
18KIT1.57562465
19WNK31.55529923
20TAOK31.55351048
21SRPK11.36990410
22BMPR1B1.31139560
23BUB11.27870769
24ACVR1B1.27154302
25MKNK11.18410664
26CDK81.12057092
27PHKG21.10509707
28PHKG11.10509707
29KDR1.08215873
30MAP4K10.97181925
31GRK10.96450443
32TGFBR10.95789035
33SYK0.95724437
34ATR0.94811083
35OXSR10.92621539
36DAPK20.90116758
37RPS6KA50.83408226
38PIK3CA0.82486036
39NEK20.80523759
40JAK10.79826286
41NEK10.78874763
42CHUK0.74864063
43MKNK20.74396072
44PAK60.73506729
45ITK0.73428044
46PASK0.71852772
47JAK20.70818267
48ADRBK10.69787005
49CSF1R0.68388375
50IKBKB0.68102958
51INSRR0.66513864
52MAP3K140.66142387
53RPS6KA40.64619351
54MAPK130.63552935
55TEC0.61332606
56NME10.60378069
57TSSK60.59868458
58PLK30.59516077
59PRKCI0.58114364
60LYN0.56816001
61CDC70.53740735
62PRKCQ0.53558173
63STK160.53455851
64VRK10.53328223
65TESK20.53118571
66IGF1R0.52504012
67TIE10.52136091
68EPHB10.51892055
69ADRBK20.47100606
70LCK0.44217840
71FGFR20.42531005
72TBK10.41626953
73DMPK0.40856358
74FES0.35969663
75BCKDK0.35449032
76OBSCN0.35247102
77PRKCE0.35029729
78ABL10.34168453
79RIPK40.34116855
80IRAK10.33194702
81STK390.32246560
82RAF10.32109013
83MUSK0.31739615
84NTRK30.31109560
85PDK10.30045277
86CASK0.29673722
87ILK0.28417914
88ATM0.28239007
89NEK60.26724844
90DAPK10.26627690
91ABL20.26059480
92PLK10.25166315
93WNK40.24526845
94STK38L0.22867639
95HCK0.22736983
96PRKACA0.21752038
97CDK60.21613246
98PRKG10.20482894
99CSNK1A1L0.20412714
100MAPKAPK20.20311679

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.05607740
2Antigen processing and presentation_Homo sapiens_hsa046122.51382424
3Proteasome_Homo sapiens_hsa030502.25759310
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24632040
5Caffeine metabolism_Homo sapiens_hsa0023210.4140809
6Nitrogen metabolism_Homo sapiens_hsa009101.93574138
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92849020
8Protein export_Homo sapiens_hsa030601.87024566
9RNA polymerase_Homo sapiens_hsa030201.86390098
10Tryptophan metabolism_Homo sapiens_hsa003801.85923877
11Graft-versus-host disease_Homo sapiens_hsa053321.82812909
12Propanoate metabolism_Homo sapiens_hsa006401.65831560
13Fanconi anemia pathway_Homo sapiens_hsa034601.63340468
14Oxidative phosphorylation_Homo sapiens_hsa001901.63078700
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.62290210
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60171319
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59063687
18Linoleic acid metabolism_Homo sapiens_hsa005911.54326651
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43945840
20RNA degradation_Homo sapiens_hsa030181.42430663
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33554880
22Phototransduction_Homo sapiens_hsa047441.31202989
23Chemical carcinogenesis_Homo sapiens_hsa052041.26017332
24Asthma_Homo sapiens_hsa053101.25861668
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24345352
26Parkinsons disease_Homo sapiens_hsa050121.19460171
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18454645
28Primary immunodeficiency_Homo sapiens_hsa053401.16537866
29One carbon pool by folate_Homo sapiens_hsa006701.14080606
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.06637687
31Dorso-ventral axis formation_Homo sapiens_hsa043201.05311035
32Mismatch repair_Homo sapiens_hsa034301.02793862
33Nicotine addiction_Homo sapiens_hsa050330.99858748
34Spliceosome_Homo sapiens_hsa030400.91735297
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90109232
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88744893
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88267466
38Olfactory transduction_Homo sapiens_hsa047400.87280719
39Homologous recombination_Homo sapiens_hsa034400.84797756
40DNA replication_Homo sapiens_hsa030300.84462788
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84064491
42Alzheimers disease_Homo sapiens_hsa050100.83103477
43Allograft rejection_Homo sapiens_hsa053300.82105748
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.77654891
45Arachidonic acid metabolism_Homo sapiens_hsa005900.76299566
46Ribosome_Homo sapiens_hsa030100.74984367
47Autoimmune thyroid disease_Homo sapiens_hsa053200.74878710
48Cardiac muscle contraction_Homo sapiens_hsa042600.67137628
49Ether lipid metabolism_Homo sapiens_hsa005650.66757809
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66510212
51Type I diabetes mellitus_Homo sapiens_hsa049400.64735934
52Huntingtons disease_Homo sapiens_hsa050160.61323507
53Taste transduction_Homo sapiens_hsa047420.60941385
54Purine metabolism_Homo sapiens_hsa002300.60498975
55Non-homologous end-joining_Homo sapiens_hsa034500.59198019
56Mineral absorption_Homo sapiens_hsa049780.56689232
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56195541
58Pyrimidine metabolism_Homo sapiens_hsa002400.55013119
59Salivary secretion_Homo sapiens_hsa049700.54397047
60Peroxisome_Homo sapiens_hsa041460.53089823
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52178013
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50951172
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47255381
64Lysine degradation_Homo sapiens_hsa003100.46557310
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.46293686
66Metabolic pathways_Homo sapiens_hsa011000.45672384
67GABAergic synapse_Homo sapiens_hsa047270.43610934
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43155594
69RNA transport_Homo sapiens_hsa030130.43127455
70Retinol metabolism_Homo sapiens_hsa008300.42262308
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40825811
72Hematopoietic cell lineage_Homo sapiens_hsa046400.40224402
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39735461
74Basal transcription factors_Homo sapiens_hsa030220.39559658
75Nucleotide excision repair_Homo sapiens_hsa034200.37983868
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35229095
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34260137
78Butanoate metabolism_Homo sapiens_hsa006500.33845846
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31113617
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30772755
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28597283
82Morphine addiction_Homo sapiens_hsa050320.28401606
83Carbon metabolism_Homo sapiens_hsa012000.27571321
84Legionellosis_Homo sapiens_hsa051340.27495338
85Malaria_Homo sapiens_hsa051440.26925090
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26564627
87beta-Alanine metabolism_Homo sapiens_hsa004100.26189141
88Fatty acid degradation_Homo sapiens_hsa000710.24629012
89Renin secretion_Homo sapiens_hsa049240.24405092
90Ovarian steroidogenesis_Homo sapiens_hsa049130.23693991
91Systemic lupus erythematosus_Homo sapiens_hsa053220.23436780
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23356622
93Oocyte meiosis_Homo sapiens_hsa041140.21916259
94Arginine biosynthesis_Homo sapiens_hsa002200.20709631
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.20354329
96Steroid biosynthesis_Homo sapiens_hsa001000.19970470
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19092590
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.18614263
99Serotonergic synapse_Homo sapiens_hsa047260.18223409
100Calcium signaling pathway_Homo sapiens_hsa040200.15285057

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