ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.34943749
2	ATP synthesis coupled proton transport (GO:0015986)	7.00016122
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.00016122
4	ribosomal small subunit biogenesis (GO:0042274)	6.66177217
5	viral transcription (GO:0019083)	6.41228882
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.34092782
7	translational termination (GO:0006415)	6.18881920
8	chaperone-mediated protein transport (GO:0072321)	5.91067269
9	respiratory electron transport chain (GO:0022904)	5.65144541
10	cotranslational protein targeting to membrane (GO:0006613)	5.64188774
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.59898788
12	protein targeting to ER (GO:0045047)	5.55388105
13	ribosomal small subunit assembly (GO:0000028)	5.52062468
14	electron transport chain (GO:0022900)	5.49695316
15	protein localization to endoplasmic reticulum (GO:0070972)	5.33175597
16	protein neddylation (GO:0045116)	5.30613566
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.28706752
18	ribosomal large subunit biogenesis (GO:0042273)	5.15206115
19	translational elongation (GO:0006414)	5.04695471
20	cellular protein complex disassembly (GO:0043624)	4.97896797
21	viral life cycle (GO:0019058)	4.93790523
22	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.90664998
23	rhodopsin mediated signaling pathway (GO:0016056)	4.78622032
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.78343475
25	proteasome assembly (GO:0043248)	4.74768848
26	translational initiation (GO:0006413)	4.64920053
27	maturation of SSU-rRNA (GO:0030490)	4.60637333
28	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.52786230
29	protein complex biogenesis (GO:0070271)	4.42072662
30	GTP biosynthetic process (GO:0006183)	4.29181660
31	translation (GO:0006412)	4.29148922
32	protein complex disassembly (GO:0043241)	4.17823820
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.14975759
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.14975759
35	NADH dehydrogenase complex assembly (GO:0010257)	4.14975759
36	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.09549271
37	termination of RNA polymerase III transcription (GO:0006386)	4.09549271
38	macromolecular complex disassembly (GO:0032984)	3.99249075
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.97082009
40	regulation of mitochondrial translation (GO:0070129)	3.93991803
41	RNA catabolic process (GO:0006401)	3.88328610
42	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.85783546
43	sequestering of actin monomers (GO:0042989)	3.84949714
44	GMP metabolic process (GO:0046037)	3.83354973
45	protein targeting to mitochondrion (GO:0006626)	3.81553757
46	inner mitochondrial membrane organization (GO:0007007)	3.79316319
47	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.77755041
48	protein targeting to membrane (GO:0006612)	3.76648625
49	establishment of protein localization to mitochondrion (GO:0072655)	3.75822996
50	7-methylguanosine mRNA capping (GO:0006370)	3.72281743
51	7-methylguanosine RNA capping (GO:0009452)	3.69866021
52	RNA capping (GO:0036260)	3.69866021
53	guanosine-containing compound biosynthetic process (GO:1901070)	3.69660692
54	retinal cone cell development (GO:0046549)	3.68257480
55	chromatin remodeling at centromere (GO:0031055)	3.66357846
56	establishment of integrated proviral latency (GO:0075713)	3.66032643
57	UTP biosynthetic process (GO:0006228)	3.64572793
58	CENP-A containing nucleosome assembly (GO:0034080)	3.58518327
59	regulation of cellular amino acid metabolic process (GO:0006521)	3.53871724
60	cellular component biogenesis (GO:0044085)	3.52949342
61	hydrogen ion transmembrane transport (GO:1902600)	3.50406679
62	ribonucleoprotein complex biogenesis (GO:0022613)	3.49980017
63	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.49287309
64	protein localization to mitochondrion (GO:0070585)	3.48522459
65	negative regulation of ligase activity (GO:0051352)	3.48170546
66	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.48170546
67	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.44480538
68	rRNA modification (GO:0000154)	3.42185359
69	establishment of viral latency (GO:0019043)	3.40086448
70	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.37436333
71	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.34950789
72	cullin deneddylation (GO:0010388)	3.31362871
73	establishment of protein localization to membrane (GO:0090150)	3.31323682
74	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.30964777
75	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.28112769
76	oxidative phosphorylation (GO:0006119)	3.27452836
77	protein targeting (GO:0006605)	3.26809774
78	ATP biosynthetic process (GO:0006754)	3.26460352
79	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.26203329
80	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.26203329
81	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.25727012
82	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.25727012
83	intracellular protein transmembrane import (GO:0044743)	3.24944335
84	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.23498783
85	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.23498783
86	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.23498783
87	pseudouridine synthesis (GO:0001522)	3.23114486
88	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.18867430
89	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.18316458
90	nucleoside triphosphate biosynthetic process (GO:0009142)	3.17932739
91	mitochondrial transport (GO:0006839)	3.17879917
92	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.14908209
93	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.14908209
94	protein-cofactor linkage (GO:0018065)	3.14301860
95	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.11792692
96	spliceosomal snRNP assembly (GO:0000387)	3.11432036
97	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.10235493
98	proton transport (GO:0015992)	3.09010802
99	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.08748145
100	photoreceptor cell maintenance (GO:0045494)	3.08171616
101	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.07875104
102	establishment of protein localization to organelle (GO:0072594)	3.07501615
103	CTP biosynthetic process (GO:0006241)	3.06629342
104	CTP metabolic process (GO:0046036)	3.06629342
105	DNA damage response, detection of DNA damage (GO:0042769)	3.06161459
106	cytochrome complex assembly (GO:0017004)	3.06125591
107	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.04051308
108	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.04051308
109	respiratory chain complex IV assembly (GO:0008535)	3.03109288
110	spliceosomal complex assembly (GO:0000245)	3.03109186
111	rRNA processing (GO:0006364)	3.03057836
112	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02603923
113	protein deneddylation (GO:0000338)	3.00686578
114	mRNA catabolic process (GO:0006402)	2.99678655
115	hydrogen transport (GO:0006818)	2.99071303
116	water-soluble vitamin biosynthetic process (GO:0042364)	2.98078538
117	photoreceptor cell development (GO:0042461)	2.97020505
118	DNA deamination (GO:0045006)	2.96775392
119	peptidyl-histidine modification (GO:0018202)	2.95162743
120	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.94732835
121	UTP metabolic process (GO:0046051)	2.94387236
122	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.94342462
123	rRNA metabolic process (GO:0016072)	2.92173102
124	histone exchange (GO:0043486)	2.88023512
125	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.86405375

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.38556236
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.79607463
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.67907426
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.34066901
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.07861923
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.76441734
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.66546218
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.60867944
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.50781943
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.47532556
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.47454310
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.32321915
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.19686673
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.06441081
15	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.58853265
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.56864986
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.51853733
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.47946247
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.39500189
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.36029205
21	VDR_22108803_ChIP-Seq_LS180_Human	2.22987110
22	XRN2_22483619_ChIP-Seq_HELA_Human	2.22053990
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.21456510
24	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.21368479
25	TTF2_22483619_ChIP-Seq_HELA_Human	2.14537231
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.14101942
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10790300
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.07700905
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95525360
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.91399870
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.88965550
32	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.87318947
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.85920568
34	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.83199269
35	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.82417795
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.79837313
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.62835248
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.55656157
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54229028
40	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.54076396
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.51830713
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50785989
43	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.50338854
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39312317
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.39238437
46	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.36685129
47	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.32292654
48	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.27156159
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.26225868
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25916520
51	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.22757505
52	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.21331868
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20910351
54	FUS_26573619_Chip-Seq_HEK293_Human	1.20352395
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.19639322
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18251660
57	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.17867992
58	ZNF274_21170338_ChIP-Seq_K562_Hela	1.16866310
59	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.15451777
60	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.15413868
61	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13069107
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12751605
63	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.11233009
64	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.09490877
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08733342
66	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06902392
67	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.05897629
68	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.05332862
69	TAF15_26573619_Chip-Seq_HEK293_Human	1.03493803
70	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02854755
71	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02602651
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01221182
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00828918
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00704322
75	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.99379223
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98824463
77	TP53_22573176_ChIP-Seq_HFKS_Human	0.98594684
78	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.95592650
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95582541
80	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.94554197
81	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.92011465
82	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.89917801
83	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.87715722
84	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.87605159
85	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.87229200
86	E2F7_22180533_ChIP-Seq_HELA_Human	0.86226824
87	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.84280799
88	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.83800771
89	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.83361815
90	EZH2_22144423_ChIP-Seq_EOC_Human	0.83360323
91	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.83274221
92	EWS_26573619_Chip-Seq_HEK293_Human	0.83239298
93	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.82998532
94	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82470870
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.82247396
96	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.81096166
97	IGF1R_20145208_ChIP-Seq_DFB_Human	0.80731237
98	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.80395045
99	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.78314066
100	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.78036579
101	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.77946311
102	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.77461343
103	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.76415520
104	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.75638331
105	ER_23166858_ChIP-Seq_MCF-7_Human	0.75277083
106	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.74530949
107	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.74062865
108	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.72498781
109	AR_20517297_ChIP-Seq_VCAP_Human	0.71654099
110	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.71648272
111	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.71648272
112	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.71158871
113	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.70856632
114	HTT_18923047_ChIP-ChIP_STHdh_Human	0.69397347
115	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.68404902
116	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.68154920
117	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.67714947
118	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.67255951
119	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.67010320
120	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.66490878
121	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.65609583
122	KDM5A_27292631_Chip-Seq_BREAST_Human	0.65347752
123	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.65043190
124	STAT1_20625510_ChIP-Seq_HELA_Human	0.64042262
125	ELF5_23300383_ChIP-Seq_T47D_Human	0.63285333

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.94762080
2	MP0003011_delayed_dark_adaptation	4.27420342
3	MP0005551_abnormal_eye_electrophysiolog	4.11373159
4	MP0003880_abnormal_central_pattern	3.76739731
5	MP0006072_abnormal_retinal_apoptosis	3.56152156
6	MP0001529_abnormal_vocalization	3.10517816
7	MP0005253_abnormal_eye_physiology	3.06665316
8	MP0002638_abnormal_pupillary_reflex	2.76939980
9	MP0001986_abnormal_taste_sensitivity	2.61216855
10	MP0001905_abnormal_dopamine_level	2.54836941
11	MP0003806_abnormal_nucleotide_metabolis	2.47263543
12	MP0003136_yellow_coat_color	2.46731882
13	MP0006276_abnormal_autonomic_nervous	2.35905613
14	MP0006292_abnormal_olfactory_placode	2.29760122
15	MP0003693_abnormal_embryo_hatching	2.20014296
16	MP0005423_abnormal_somatic_nervous	2.02757386
17	MP0001188_hyperpigmentation	1.90890270
18	MP0005409_darkened_coat_color	1.80450870
19	MP0001293_anophthalmia	1.79832476
20	MP0008932_abnormal_embryonic_tissue	1.79594706
21	MP0002163_abnormal_gland_morphology	1.79583552
22	MP0005195_abnormal_posterior_eye	1.76204944
23	MP0004957_abnormal_blastocyst_morpholog	1.73290385
24	MP0002277_abnormal_respiratory_mucosa	1.68164031
25	MP0004142_abnormal_muscle_tone	1.65094662
26	MP0003950_abnormal_plasma_membrane	1.61984026
27	MP0002102_abnormal_ear_morphology	1.61597800
28	MP0008995_early_reproductive_senescence	1.56445539
29	MP0003315_abnormal_perineum_morphology	1.50155424
30	MP0008789_abnormal_olfactory_epithelium	1.49980479
31	MP0001968_abnormal_touch/_nociception	1.49492594
32	MP0002653_abnormal_ependyma_morphology	1.48541916
33	MP0000566_synostosis	1.47843640
34	MP0002736_abnormal_nociception_after	1.46975727
35	MP0009697_abnormal_copulation	1.44594242
36	MP0001727_abnormal_embryo_implantation	1.43298284
37	MP0003941_abnormal_skin_development	1.42843716
38	MP0002837_dystrophic_cardiac_calcinosis	1.42820442
39	MP0002734_abnormal_mechanical_nocicepti	1.42386652
40	MP0002752_abnormal_somatic_nervous	1.38349637
41	MP0002272_abnormal_nervous_system	1.35888426
42	MP0003718_maternal_effect	1.34788939
43	MP0008877_abnormal_DNA_methylation	1.34307192
44	MP0005391_vision/eye_phenotype	1.30938576
45	MP0000372_irregular_coat_pigmentation	1.29952223
46	MP0002229_neurodegeneration	1.28468065
47	MP0005379_endocrine/exocrine_gland_phen	1.28054451
48	MP0002938_white_spotting	1.25357123
49	MP0004742_abnormal_vestibular_system	1.24506218
50	MP0008058_abnormal_DNA_repair	1.19129565
51	MP0004381_abnormal_hair_follicle	1.19068187
52	MP0002751_abnormal_autonomic_nervous	1.18555347
53	MP0002095_abnormal_skin_pigmentation	1.15800501
54	MP0008057_abnormal_DNA_replication	1.14136920
55	MP0005394_taste/olfaction_phenotype	1.13885890
56	MP0005499_abnormal_olfactory_system	1.13885890
57	MP0001970_abnormal_pain_threshold	1.11314359
58	MP0001440_abnormal_grooming_behavior	1.10048253
59	MP0001984_abnormal_olfaction	1.09629702
60	MP0006035_abnormal_mitochondrial_morpho	1.09558214
61	MP0002735_abnormal_chemical_nociception	1.09182483
62	MP0002234_abnormal_pharynx_morphology	1.08224883
63	MP0005389_reproductive_system_phenotype	1.07694287
64	MP0002064_seizures	1.07445791
65	MP0002148_abnormal_hypersensitivity_rea	1.04784134
66	MP0001286_abnormal_eye_development	1.04467574
67	MP0008872_abnormal_physiological_respon	1.04166808
68	MP0010386_abnormal_urinary_bladder	1.02982114
69	MP0004133_heterotaxia	1.02471275
70	MP0001919_abnormal_reproductive_system	1.02229786
71	MP0003567_abnormal_fetal_cardiomyocyte	1.00863568
72	MP0001486_abnormal_startle_reflex	1.00300000
73	MP0006036_abnormal_mitochondrial_physio	0.99274547
74	MP0001324_abnormal_eye_pigmentation	0.98459231
75	MP0003077_abnormal_cell_cycle	0.97745416
76	MP0009745_abnormal_behavioral_response	0.97732624
77	MP0004270_analgesia	0.97012002
78	MP0001485_abnormal_pinna_reflex	0.96900819
79	MP0003878_abnormal_ear_physiology	0.95244513
80	MP0005377_hearing/vestibular/ear_phenot	0.95244513
81	MP0002882_abnormal_neuron_morphology	0.95212207
82	MP0003938_abnormal_ear_development	0.94434086
83	MP0004145_abnormal_muscle_electrophysio	0.94151076
84	MP0002210_abnormal_sex_determination	0.94078084
85	MP0009046_muscle_twitch	0.92775484
86	MP0005075_abnormal_melanosome_morpholog	0.92135574
87	MP0005171_absent_coat_pigmentation	0.91847253
88	MP0005645_abnormal_hypothalamus_physiol	0.91232186
89	MP0008875_abnormal_xenobiotic_pharmacok	0.91138874
90	MP0008007_abnormal_cellular_replicative	0.89691642
91	MP0003937_abnormal_limbs/digits/tail_de	0.89549380
92	MP0003122_maternal_imprinting	0.89416355
93	MP0002067_abnormal_sensory_capabilities	0.89332526
94	MP0002132_abnormal_respiratory_system	0.88000855
95	MP0002733_abnormal_thermal_nociception	0.87148829
96	MP0009333_abnormal_splenocyte_physiolog	0.87073424
97	MP0003786_premature_aging	0.87020228
98	MP0004924_abnormal_behavior	0.86866711
99	MP0005386_behavior/neurological_phenoty	0.86866711
100	MP0005646_abnormal_pituitary_gland	0.86232853
101	MP0002572_abnormal_emotion/affect_behav	0.86127861
102	MP0000026_abnormal_inner_ear	0.85406863
103	MP0000778_abnormal_nervous_system	0.84193251
104	MP0003121_genomic_imprinting	0.81348209
105	MP0001963_abnormal_hearing_physiology	0.80002373
106	MP0002697_abnormal_eye_size	0.79435536
107	MP0002090_abnormal_vision	0.79096231
108	MP0002184_abnormal_innervation	0.78970520
109	MP0010094_abnormal_chromosome_stability	0.78575029
110	MP0003283_abnormal_digestive_organ	0.78460403
111	MP0000920_abnormal_myelination	0.78275485
112	MP0003724_increased_susceptibility_to	0.78214024
113	MP0002233_abnormal_nose_morphology	0.77915606
114	MP0005174_abnormal_tail_pigmentation	0.77738577
115	MP0002282_abnormal_trachea_morphology	0.76399438
116	MP0005084_abnormal_gallbladder_morpholo	0.76066060
117	MP0001346_abnormal_lacrimal_gland	0.75518644
118	MP0005408_hypopigmentation	0.75269646
119	MP0004885_abnormal_endolymph	0.74346659
120	MP0003186_abnormal_redox_activity	0.73301302
121	MP0000631_abnormal_neuroendocrine_gland	0.71972551
122	MP0001145_abnormal_male_reproductive	0.71867369
123	MP0004147_increased_porphyrin_level	0.71714083
124	MP0009250_abnormal_appendicular_skeleto	0.70935253
125	MP0000049_abnormal_middle_ear	0.70219008
126	MP0000653_abnormal_sex_gland	0.69873707
127	MP0001764_abnormal_homeostasis	0.69438322
128	MP0003119_abnormal_digestive_system	0.69023151
129	MP0001542_abnormal_bone_strength	0.68834150
130	MP0003123_paternal_imprinting	0.68354895
131	MP0002876_abnormal_thyroid_physiology	0.68001571
132	MP0001929_abnormal_gametogenesis	0.67991858
133	MP0010030_abnormal_orbit_morphology	0.66671807
134	MP0003635_abnormal_synaptic_transmissio	0.63499153
135	MP0001501_abnormal_sleep_pattern	0.59490548
136	MP0005671_abnormal_response_to	0.59446506
137	MP0009785_altered_susceptibility_to	0.57746232
138	MP0002160_abnormal_reproductive_system	0.56695269
139	MP0002557_abnormal_social/conspecific_i	0.56688451
140	MP0003111_abnormal_nucleus_morphology	0.52354318

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.08433015
2	Congenital stationary night blindness (HP:0007642)	5.48502564
3	Mitochondrial inheritance (HP:0001427)	5.39434380
4	Abnormal mitochondria in muscle tissue (HP:0008316)	5.36905691
5	Progressive macrocephaly (HP:0004481)	5.11441130
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.05812600
7	Increased hepatocellular lipid droplets (HP:0006565)	4.64907869
8	Acute encephalopathy (HP:0006846)	4.58257806
9	Abnormal rod and cone electroretinograms (HP:0008323)	4.47779418
10	Abnormality of cells of the erythroid lineage (HP:0012130)	4.45831154
11	Increased CSF lactate (HP:0002490)	4.44767486
12	Hepatocellular necrosis (HP:0001404)	4.33537548
13	Optic disc pallor (HP:0000543)	4.31384519
14	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.07655096
15	Abnormal number of erythroid precursors (HP:0012131)	3.96803381
16	Renal Fanconi syndrome (HP:0001994)	3.96448633
17	Lipid accumulation in hepatocytes (HP:0006561)	3.91380172
18	Bony spicule pigmentary retinopathy (HP:0007737)	3.89785399
19	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.77104599
20	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.75168618
21	Reticulocytopenia (HP:0001896)	3.73440665
22	Dyschromatopsia (HP:0007641)	3.66316054
23	Attenuation of retinal blood vessels (HP:0007843)	3.54626614
24	Macrocytic anemia (HP:0001972)	3.50449566
25	Hepatic necrosis (HP:0002605)	3.48363003
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.38720673
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.38720673
28	Pendular nystagmus (HP:0012043)	3.38331883
29	3-Methylglutaconic aciduria (HP:0003535)	3.32932453
30	Exertional dyspnea (HP:0002875)	3.31882985
31	Increased intramyocellular lipid droplets (HP:0012240)	3.16086319
32	Exercise intolerance (HP:0003546)	3.09276418
33	Respiratory failure (HP:0002878)	3.06344456
34	Pallor (HP:0000980)	3.05164195
35	Septo-optic dysplasia (HP:0100842)	3.03285685
36	Parakeratosis (HP:0001036)	2.97127484
37	Abnormality of glycolysis (HP:0004366)	2.94011181
38	Increased serum pyruvate (HP:0003542)	2.94011181
39	Severe visual impairment (HP:0001141)	2.93720321
40	Leukodystrophy (HP:0002415)	2.89671587
41	Decreased central vision (HP:0007663)	2.88875953
42	Abnormality of macular pigmentation (HP:0008002)	2.87556697
43	Cerebral edema (HP:0002181)	2.81784835
44	Increased serum lactate (HP:0002151)	2.72788382
45	Abolished electroretinogram (ERG) (HP:0000550)	2.66267022
46	Respiratory difficulties (HP:0002880)	2.61893502
47	Medial flaring of the eyebrow (HP:0010747)	2.60303656
48	Congenital ichthyosiform erythroderma (HP:0007431)	2.59186904
49	Colon cancer (HP:0003003)	2.58726112
50	Oral leukoplakia (HP:0002745)	2.56829075
51	Abnormality of renal resorption (HP:0011038)	2.54854131
52	Pigmentary retinal degeneration (HP:0001146)	2.53292746
53	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.51457092
54	Lactic acidosis (HP:0003128)	2.50663943
55	Central scotoma (HP:0000603)	2.42118879
56	Increased muscle lipid content (HP:0009058)	2.40354434
57	Gait imbalance (HP:0002141)	2.39627090
58	Congenital primary aphakia (HP:0007707)	2.39098550
59	Increased corneal curvature (HP:0100692)	2.31376201
60	Keratoconus (HP:0000563)	2.31376201
61	Lethargy (HP:0001254)	2.31371222
62	Chorioretinal atrophy (HP:0000533)	2.29411635
63	Photophobia (HP:0000613)	2.22457883
64	Abnormality of midbrain morphology (HP:0002418)	2.21654428
65	Molar tooth sign on MRI (HP:0002419)	2.21654428
66	Nephrogenic diabetes insipidus (HP:0009806)	2.19942002
67	Methylmalonic acidemia (HP:0002912)	2.18714480
68	Retinitis pigmentosa (HP:0000510)	2.13811729
69	Cerebral hypomyelination (HP:0006808)	2.13727456
70	X-linked dominant inheritance (HP:0001423)	2.11907702
71	Scotoma (HP:0000575)	2.08549712
72	Generalized aminoaciduria (HP:0002909)	2.08276873
73	Hyperphosphaturia (HP:0003109)	2.06558966
74	Myokymia (HP:0002411)	2.05770117
75	Absent septum pellucidum (HP:0001331)	2.04657533
76	Absent thumb (HP:0009777)	2.04201606
77	Hyperglycinemia (HP:0002154)	2.03820150
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98480344
79	Methylmalonic aciduria (HP:0012120)	1.97918188
80	Breast hypoplasia (HP:0003187)	1.95765408
81	Bilateral microphthalmos (HP:0007633)	1.94585598
82	Vaginal atresia (HP:0000148)	1.93394134
83	Rib fusion (HP:0000902)	1.93076478
84	Triphalangeal thumb (HP:0001199)	1.93005829
85	Congenital sensorineural hearing impairment (HP:0008527)	1.92767342
86	Pancytopenia (HP:0001876)	1.92589877
87	Maternal diabetes (HP:0009800)	1.89418426
88	Abnormality of placental membranes (HP:0011409)	1.87394646
89	Amniotic constriction ring (HP:0009775)	1.87394646
90	Stenosis of the external auditory canal (HP:0000402)	1.87257494
91	Genital tract atresia (HP:0001827)	1.86495536
92	Pancreatic cysts (HP:0001737)	1.84114974
93	Abnormal pupillary function (HP:0007686)	1.83515660
94	Partial duplication of thumb phalanx (HP:0009944)	1.83282384
95	Partial duplication of the phalanx of hand (HP:0009999)	1.82129085
96	Type II diabetes mellitus (HP:0005978)	1.81677020
97	Depressed nasal ridge (HP:0000457)	1.81671094
98	Cleft eyelid (HP:0000625)	1.81014791
99	Aplastic anemia (HP:0001915)	1.80327767
100	Megaloblastic anemia (HP:0001889)	1.79510153
101	Degeneration of anterior horn cells (HP:0002398)	1.78164759
102	Abnormality of the anterior horn cell (HP:0006802)	1.78164759
103	Meckel diverticulum (HP:0002245)	1.78124421
104	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77773400
105	Emotional lability (HP:0000712)	1.76792377
106	True hermaphroditism (HP:0010459)	1.75689670
107	Nephronophthisis (HP:0000090)	1.75180531
108	Concave nail (HP:0001598)	1.74702295
109	Abnormality of the septum pellucidum (HP:0007375)	1.74098071
110	Optic nerve hypoplasia (HP:0000609)	1.73956101
111	Hypoplasia of the pons (HP:0012110)	1.72211389
112	Esophageal atresia (HP:0002032)	1.71560596
113	Congenital, generalized hypertrichosis (HP:0004540)	1.71044005
114	Pancreatic fibrosis (HP:0100732)	1.70791581
115	Constricted visual fields (HP:0001133)	1.70318202
116	Sensory axonal neuropathy (HP:0003390)	1.68616507
117	Abnormality of serum amino acid levels (HP:0003112)	1.68531440
118	Type I transferrin isoform profile (HP:0003642)	1.68479352
119	CNS demyelination (HP:0007305)	1.67776062
120	Anophthalmia (HP:0000528)	1.66273422
121	Abnormality of the ileum (HP:0001549)	1.66036779
122	Abnormality of the labia minora (HP:0012880)	1.65570663
123	Abnormal number of incisors (HP:0011064)	1.65487225
124	Abnormal urine phosphate concentration (HP:0012599)	1.64627298
125	Sparse eyelashes (HP:0000653)	1.64508035
126	Abnormal respiratory motile cilium physiology (HP:0012261)	1.64388860
127	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.64201346
128	Male pseudohermaphroditism (HP:0000037)	1.63747140
129	Progressive external ophthalmoplegia (HP:0000590)	1.63201823
130	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.62955362
131	Microvesicular hepatic steatosis (HP:0001414)	1.62773145
132	Abnormal respiratory motile cilium morphology (HP:0005938)	1.62030322
133	Abnormal respiratory epithelium morphology (HP:0012253)	1.62030322
134	Abnormality of dental color (HP:0011073)	1.61053351
135	Abnormal hemoglobin (HP:0011902)	1.60380990
136	Abnormality of the pons (HP:0007361)	1.58915235
137	Renal tubular dysfunction (HP:0000124)	1.57813379
138	Delusions (HP:0000746)	1.57540104
139	Hyperalaninemia (HP:0003348)	1.57529871
140	Abnormality of urine glucose concentration (HP:0011016)	1.56310251
141	Glycosuria (HP:0003076)	1.56310251
142	Hypothermia (HP:0002045)	1.55226516
143	Macular degeneration (HP:0000608)	1.55154039
144	Septate vagina (HP:0001153)	1.54112503
145	Sclerocornea (HP:0000647)	1.53376164

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.78290264
2	PBK	4.34874639
3	CDC7	3.31816950
4	NME2	3.28867449
5	STK16	3.26276097
6	EIF2AK1	3.11120322
7	TLK1	2.99929489
8	ZAK	2.95654371
9	BUB1	2.84143775
10	NME1	2.81346302
11	CDK19	2.47073979
12	EIF2AK3	2.43096006
13	MST4	2.25741127
14	SRPK1	2.19239697
15	PNCK	2.10687804
16	MAP3K12	2.06057825
17	TAF1	2.02127294
18	WEE1	2.02007370
19	VRK1	1.98327334
20	CASK	1.97212347
21	NUAK1	1.79239772
22	STK39	1.75689665
23	ARAF	1.65361438
24	GRK1	1.64344654
25	PIM2	1.63795986
26	TESK2	1.60926585
27	BCR	1.56852733
28	PASK	1.51248996
29	BCKDK	1.46422933
30	LIMK1	1.42475117
31	PLK4	1.35611295
32	TNIK	1.34559901
33	MAP4K2	1.34142612
34	BMPR1B	1.33912892
35	MKNK1	1.25038887
36	DYRK2	1.22692681
37	GRK7	1.19985545
38	GRK5	1.19471064
39	MKNK2	1.19185539
40	NEK1	1.17305701
41	OXSR1	1.13557952
42	TTK	1.06522706
43	IRAK2	1.02758162
44	CHEK2	1.02714807
45	MYLK	1.00035973
46	INSRR	0.99051877
47	BRSK2	0.98072907
48	EIF2AK2	0.97153552
49	BMPR2	0.90970424
50	IRAK4	0.90511725
51	ADRBK1	0.89913640
52	MARK1	0.89628745
53	ADRBK2	0.88600742
54	DYRK3	0.87902427
55	RPS6KA5	0.87091323
56	TSSK6	0.86199499
57	AURKA	0.85639455
58	BRAF	0.85589018
59	EPHB2	0.85554848
60	RIPK4	0.84053590
61	WNK4	0.83275819
62	TESK1	0.82990419
63	ABL2	0.82890473
64	PLK2	0.81242792
65	NEK2	0.80655163
66	BLK	0.80589913
67	PLK3	0.80572651
68	CSNK1G3	0.78214033
69	MAPK15	0.77492230
70	LRRK2	0.75434348
71	UHMK1	0.74912829
72	PRKCG	0.70367234
73	IRAK1	0.69706280
74	FES	0.68920860
75	IRAK3	0.68250923
76	MAP3K11	0.67761951
77	CAMK2B	0.67430474
78	PINK1	0.66837289
79	ATR	0.65780004
80	MAPKAPK5	0.65667085
81	CSNK2A1	0.64372469
82	MUSK	0.64057337
83	FGR	0.62209815
84	PDK2	0.60933398
85	MAP2K7	0.59611410
86	CAMK2D	0.59194756
87	PLK1	0.58837747
88	MAPK13	0.57510300
89	CSNK2A2	0.57357477
90	MAP3K4	0.56488572
91	CSNK1G2	0.54765072
92	STK4	0.54509877
93	TXK	0.53278063
94	CDK14	0.53046067
95	YES1	0.52539226
96	DAPK3	0.50651667
97	TEC	0.50632187
98	PAK1	0.48530338
99	ACVR1B	0.47072672
100	KDR	0.46945821
101	CAMK2A	0.45908225
102	TAOK3	0.45645839
103	CDK11A	0.44796824
104	CLK1	0.43875530
105	CDK8	0.43551845
106	CDK3	0.43315756
107	AURKB	0.42782178
108	OBSCN	0.42117304
109	NEK6	0.41606923
110	CSNK1E	0.41229380
111	WNK3	0.40609707
112	CSNK1A1	0.40277581
113	TGFBR1	0.40174201
114	PRKCI	0.39972748
115	CCNB1	0.39784609
116	CSNK1G1	0.39184494
117	PIM1	0.38716664
118	IKBKB	0.38440134
119	LYN	0.38248188
120	PKN1	0.36875728
121	TIE1	0.35685590
122	CDK18	0.34754799
123	CDK15	0.33730580
124	CAMK2G	0.32969109
125	SYK	0.32800330
126	BRSK1	0.32577611
127	DAPK1	0.32188327
128	PRKACA	0.31362116
129	ILK	0.30796715
130	PRKCE	0.30320961
131	ROCK2	0.30106092
132	RPS6KA4	0.29724555
133	ATM	0.27476681
134	MINK1	0.25246526

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.39505594
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.13341185
3	Phototransduction_Homo sapiens_hsa04744	4.70448013
4	Parkinsons disease_Homo sapiens_hsa05012	4.32060984
5	Proteasome_Homo sapiens_hsa03050	4.14545383
6	Alzheimers disease_Homo sapiens_hsa05010	3.26936025
7	RNA polymerase_Homo sapiens_hsa03020	3.24921373
8	Huntingtons disease_Homo sapiens_hsa05016	3.24595460
9	Protein export_Homo sapiens_hsa03060	2.87639839
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.69766341
11	Spliceosome_Homo sapiens_hsa03040	2.06988140
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96832004
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.80219336
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.79164721
15	DNA replication_Homo sapiens_hsa03030	1.57985537
16	Mismatch repair_Homo sapiens_hsa03430	1.57250806
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.57046238
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.50865022
19	Homologous recombination_Homo sapiens_hsa03440	1.48388642
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.39439220
21	Basal transcription factors_Homo sapiens_hsa03022	1.35628677
22	One carbon pool by folate_Homo sapiens_hsa00670	1.25842410
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23750105
24	Purine metabolism_Homo sapiens_hsa00230	1.18698914
25	RNA transport_Homo sapiens_hsa03013	1.14401217
26	Vibrio cholerae infection_Homo sapiens_hsa05110	0.95906099
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95806250
28	RNA degradation_Homo sapiens_hsa03018	0.93416888
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.93140523
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92420717
31	Rheumatoid arthritis_Homo sapiens_hsa05323	0.87136317
32	Base excision repair_Homo sapiens_hsa03410	0.86105471
33	Graft-versus-host disease_Homo sapiens_hsa05332	0.84442402
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.82073280
35	Fanconi anemia pathway_Homo sapiens_hsa03460	0.81615194
36	Nicotine addiction_Homo sapiens_hsa05033	0.79471160
37	Sulfur metabolism_Homo sapiens_hsa00920	0.77448971
38	Fatty acid elongation_Homo sapiens_hsa00062	0.76458302
39	Pyruvate metabolism_Homo sapiens_hsa00620	0.76104802
40	Non-homologous end-joining_Homo sapiens_hsa03450	0.74454988
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.73589047
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.73087811
43	Serotonergic synapse_Homo sapiens_hsa04726	0.71944532
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70510695
45	Asthma_Homo sapiens_hsa05310	0.70382379
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67758962
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66999717
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66903386
49	Allograft rejection_Homo sapiens_hsa05330	0.66723774
50	Propanoate metabolism_Homo sapiens_hsa00640	0.65427824
51	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.63464774
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62056080
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61093261
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60836852
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60319713
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.59688994
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.58557942
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.58229060
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57583829
60	Metabolic pathways_Homo sapiens_hsa01100	0.56955379
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56725535
62	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54541642
63	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54531999
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.52627647
65	Sulfur relay system_Homo sapiens_hsa04122	0.52254083
66	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51803916
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51191494
68	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51015372
69	Cell cycle_Homo sapiens_hsa04110	0.50765640
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50296400
71	Peroxisome_Homo sapiens_hsa04146	0.50107279
72	Regulation of autophagy_Homo sapiens_hsa04140	0.49663949
73	Glutathione metabolism_Homo sapiens_hsa00480	0.49555991
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49522283
75	Alcoholism_Homo sapiens_hsa05034	0.49390395
76	Phagosome_Homo sapiens_hsa04145	0.49285481
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49270123
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.48930932
79	Caffeine metabolism_Homo sapiens_hsa00232	0.48728912
80	Butanoate metabolism_Homo sapiens_hsa00650	0.48544822
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47738355
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44629905
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.42751745
84	Tryptophan metabolism_Homo sapiens_hsa00380	0.42630513
85	Retinol metabolism_Homo sapiens_hsa00830	0.40629904
86	Folate biosynthesis_Homo sapiens_hsa00790	0.40258758
87	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.38606309
88	GABAergic synapse_Homo sapiens_hsa04727	0.38598151
89	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.33019782
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32035703
91	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.31901829
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31596851
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.30242205
94	Morphine addiction_Homo sapiens_hsa05032	0.29586004
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.29419031
96	Oocyte meiosis_Homo sapiens_hsa04114	0.27022892
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.26515135
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.25915056
99	Taste transduction_Homo sapiens_hsa04742	0.24634211
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.24493612
101	p53 signaling pathway_Homo sapiens_hsa04115	0.24181129
102	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.23735821
103	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.21688702
104	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.21081845
105	Dopaminergic synapse_Homo sapiens_hsa04728	0.19915256
106	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.19823022
107	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.19354299
108	beta-Alanine metabolism_Homo sapiens_hsa00410	0.19208894
109	African trypanosomiasis_Homo sapiens_hsa05143	0.19203724
110	Fatty acid degradation_Homo sapiens_hsa00071	0.18558637
111	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.18442095
112	Glutamatergic synapse_Homo sapiens_hsa04724	0.17917697
113	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.17174485
114	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.14799405
115	Long-term depression_Homo sapiens_hsa04730	0.12464948
116	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.12423346
117	Tyrosine metabolism_Homo sapiens_hsa00350	0.12036843
118	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.11813492
119	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.10959985
120	Cholinergic synapse_Homo sapiens_hsa04725	0.09865508
121	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.09072453
122	Mineral absorption_Homo sapiens_hsa04978	0.07640959
123	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.07378279
124	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.06537776
125	Circadian entrainment_Homo sapiens_hsa04713	0.05756675
126	Salmonella infection_Homo sapiens_hsa05132	0.05299240
127	Olfactory transduction_Homo sapiens_hsa04740	0.04694367
128	Antigen processing and presentation_Homo sapiens_hsa04612	0.04368146
129	Malaria_Homo sapiens_hsa05144	0.03553307
130	Pertussis_Homo sapiens_hsa05133	0.03280471
131	Axon guidance_Homo sapiens_hsa04360	0.03209825
132	Pentose phosphate pathway_Homo sapiens_hsa00030	0.02622428

TMA7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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