TMBIM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)4.79827160
2aldehyde catabolic process (GO:0046185)3.84992465
3L-phenylalanine catabolic process (GO:0006559)3.78959573
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.78959573
5aminoglycoside antibiotic metabolic process (GO:0030647)3.71426559
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.69193067
7L-phenylalanine metabolic process (GO:0006558)3.69193067
8drug transmembrane transport (GO:0006855)3.58700730
9urate metabolic process (GO:0046415)3.45123208
10glyoxylate metabolic process (GO:0046487)3.43345223
11drug transport (GO:0015893)3.35085948
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34966376
13cysteine metabolic process (GO:0006534)3.33437910
14water-soluble vitamin biosynthetic process (GO:0042364)3.32356890
15valine metabolic process (GO:0006573)3.27170581
16aromatic amino acid family catabolic process (GO:0009074)3.09012516
17ATP synthesis coupled proton transport (GO:0015986)3.09005209
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09005209
19branched-chain amino acid metabolic process (GO:0009081)3.08038181
20cytidine metabolic process (GO:0046087)3.07661129
21cytidine catabolic process (GO:0006216)3.07661129
22cytidine deamination (GO:0009972)3.07661129
23respiratory electron transport chain (GO:0022904)3.05762162
24branched-chain amino acid catabolic process (GO:0009083)3.03422376
25neutrophil activation involved in immune response (GO:0002283)3.01389904
26electron transport chain (GO:0022900)2.99713042
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90210661
28response to interferon-beta (GO:0035456)2.90078905
29glycoside metabolic process (GO:0016137)2.88418618
30endosome to melanosome transport (GO:0035646)2.85743413
31endosome to pigment granule transport (GO:0043485)2.85743413
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.84783539
33preassembly of GPI anchor in ER membrane (GO:0016254)2.84511978
34neutrophil activation (GO:0042119)2.83527125
35sulfur amino acid catabolic process (GO:0000098)2.83303034
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82455293
37respiratory burst (GO:0045730)2.82291223
38regulation of B cell receptor signaling pathway (GO:0050855)2.78774807
39organic cation transport (GO:0015695)2.77240914
40regulation of metalloenzyme activity (GO:0048552)2.77219925
41nucleotide transmembrane transport (GO:1901679)2.75233853
42amyloid precursor protein catabolic process (GO:0042987)2.74999443
43glutathione metabolic process (GO:0006749)2.72852345
44nonribosomal peptide biosynthetic process (GO:0019184)2.67614763
45lysine catabolic process (GO:0006554)2.67569621
46lysine metabolic process (GO:0006553)2.67569621
47regulation of regulatory T cell differentiation (GO:0045589)2.67521864
48uronic acid metabolic process (GO:0006063)2.67287557
49glucuronate metabolic process (GO:0019585)2.67287557
50response to mercury ion (GO:0046689)2.66758366
51tricarboxylic acid metabolic process (GO:0072350)2.64390262
52immunoglobulin mediated immune response (GO:0016064)2.63375835
53DNA deamination (GO:0045006)2.62014483
54fatty acid beta-oxidation (GO:0006635)2.60733550
55microglial cell activation (GO:0001774)2.60668181
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60189461
57glutathione derivative metabolic process (GO:1901685)2.59664359
58glutathione derivative biosynthetic process (GO:1901687)2.59664359
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58445112
60GPI anchor biosynthetic process (GO:0006506)2.56881038
61granulocyte activation (GO:0036230)2.54641534
62hydrogen peroxide catabolic process (GO:0042744)2.54412650
63pyrimidine ribonucleoside catabolic process (GO:0046133)2.54374153
64heme metabolic process (GO:0042168)2.54168486
65GPI anchor metabolic process (GO:0006505)2.54074916
66regulation of interleukin-8 secretion (GO:2000482)2.53749746
67short-chain fatty acid metabolic process (GO:0046459)2.53624424
68C-terminal protein lipidation (GO:0006501)2.53430154
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.53275420
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.53275420
71positive regulation of mast cell activation (GO:0033005)2.52565065
72adenosine metabolic process (GO:0046085)2.52129743
73negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.51417351
74tryptophan metabolic process (GO:0006568)2.51074050
75antigen processing and presentation via MHC class Ib (GO:0002475)2.50703006
76cofactor catabolic process (GO:0051187)2.50607611
77respiratory chain complex IV assembly (GO:0008535)2.50544229
78positive regulation of mast cell activation involved in immune response (GO:0033008)2.50054169
79positive regulation of mast cell degranulation (GO:0043306)2.50054169
80T-helper 1 type immune response (GO:0042088)2.49205218
81lipid oxidation (GO:0034440)2.49057287
82fatty acid oxidation (GO:0019395)2.48925233
83reactive oxygen species biosynthetic process (GO:1903409)2.46739061
84tryptophan catabolic process (GO:0006569)2.46599532
85indole-containing compound catabolic process (GO:0042436)2.46599532
86indolalkylamine catabolic process (GO:0046218)2.46599532
87hydrogen peroxide biosynthetic process (GO:0050665)2.46593933
88positive regulation of prostaglandin secretion (GO:0032308)2.46417202
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45956643
90glutathione biosynthetic process (GO:0006750)2.45823003
91cellular glucuronidation (GO:0052695)2.45558476
92positive regulation of cellular amine metabolic process (GO:0033240)2.45300398
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.44659552
94cytochrome complex assembly (GO:0017004)2.44184530
95protein complex biogenesis (GO:0070271)2.43700529
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.43565257
97hydrogen peroxide metabolic process (GO:0042743)2.42167427
98fatty acid catabolic process (GO:0009062)2.41079772
99toxin transport (GO:1901998)2.41064517
100ketone body metabolic process (GO:1902224)2.40788650
101dopamine transport (GO:0015872)2.40537095
102production of molecular mediator involved in inflammatory response (GO:0002532)2.40092440
103positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.38806844
104cellular ketone body metabolic process (GO:0046950)2.37932500
105regulation of T cell mediated cytotoxicity (GO:0001914)2.36676766
106mannosylation (GO:0097502)2.36557178
107aromatic amino acid family metabolic process (GO:0009072)2.36533910
108peptide catabolic process (GO:0043171)2.34254632
109protein neddylation (GO:0045116)2.33594921
110platelet dense granule organization (GO:0060155)2.33342457
111positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.32893741
112regulation of memory T cell differentiation (GO:0043380)2.32254087
113peptide metabolic process (GO:0006518)2.32088480
114mitochondrial respiratory chain complex I assembly (GO:0032981)2.31772992
115NADH dehydrogenase complex assembly (GO:0010257)2.31772992
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.31772992
117xenobiotic catabolic process (GO:0042178)2.31343475
118ribosomal small subunit assembly (GO:0000028)2.30357461
119nucleoside diphosphate catabolic process (GO:0009134)2.30166283
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.29778343
121negative regulation of cell killing (GO:0031342)2.29778343
122negative regulation of acute inflammatory response (GO:0002674)2.29403136
123proton transport (GO:0015992)2.29320396
124fatty acid elongation (GO:0030497)2.28542571
125regulation of inflammatory response to antigenic stimulus (GO:0002861)2.27919593
126positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27769489
127oxidative phosphorylation (GO:0006119)2.27513439
128hydrogen transport (GO:0006818)2.27034222
129regulation of mast cell activation (GO:0033003)2.26717276
130hydrogen ion transmembrane transport (GO:1902600)2.26690226
131antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.26222738
132response to nitrosative stress (GO:0051409)2.25988223
133positive regulation of gamma-delta T cell activation (GO:0046645)2.25776406
134sequestering of metal ion (GO:0051238)2.25651120
135heme biosynthetic process (GO:0006783)2.25263927
136cellular aldehyde metabolic process (GO:0006081)2.25176686
137antigen processing and presentation of endogenous antigen (GO:0019883)2.25046389
138positive regulation of interleukin-8 secretion (GO:2000484)2.25004524
139negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.24367573
140proteasome assembly (GO:0043248)2.24061566
141negative regulation of complement activation (GO:0045916)2.22903424
142eosinophil chemotaxis (GO:0048245)2.22384988
143mast cell activation (GO:0045576)2.22382076
144mitochondrial respiratory chain complex assembly (GO:0033108)2.22327920
145response to thyroid hormone (GO:0097066)2.21640031
146aspartate family amino acid catabolic process (GO:0009068)2.20163203
147positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.20012704
148indolalkylamine metabolic process (GO:0006586)2.19855014
149positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.19804135
150cellular response to interferon-beta (GO:0035458)2.19536590
151cellular response to interleukin-15 (GO:0071350)2.19524828
152monocarboxylic acid catabolic process (GO:0072329)2.19242778
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.19174617
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.19174617
155carbohydrate derivative transport (GO:1901264)2.18261487
156regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.18239840
157secretory granule organization (GO:0033363)2.17070859
158axoneme assembly (GO:0035082)2.16496012
159C-terminal protein amino acid modification (GO:0018410)2.16100020
160cellular response to zinc ion (GO:0071294)2.14581596
161negative regulation of humoral immune response (GO:0002921)2.13140671
162B cell mediated immunity (GO:0019724)2.12585459
163vitamin biosynthetic process (GO:0009110)2.12322867
164S-adenosylmethionine metabolic process (GO:0046500)2.11596045
165leukotriene biosynthetic process (GO:0019370)2.10881716
166negative regulation of mast cell activation (GO:0033004)2.10532831
167L-fucose catabolic process (GO:0042355)2.09814663
168fucose catabolic process (GO:0019317)2.09814663
169L-fucose metabolic process (GO:0042354)2.09814663
170regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.08927786
171positive regulation of interleukin-1 beta secretion (GO:0050718)2.08584257
172dendritic cell migration (GO:0036336)2.07263895
173regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.06749475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.42444843
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.95596015
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.55829923
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.27565079
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.99855443
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.88940919
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82083445
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.76071563
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74943988
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74551941
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.67647794
12* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67320385
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.59293292
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59002084
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56228670
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42703233
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36417138
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33893171
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.30173423
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.19080356
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.19024340
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.17824682
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09584200
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.04960199
25VDR_22108803_ChIP-Seq_LS180_Human1.99628207
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98266021
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94979190
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94583357
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93275307
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86427415
31* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84010858
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82578537
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80151363
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79619173
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79584595
36* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77939676
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77167617
38* EST1_17652178_ChIP-ChIP_JURKAT_Human1.76616674
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71418069
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70708107
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69119447
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68751691
43* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68727374
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.68447267
45ZNF274_21170338_ChIP-Seq_K562_Hela1.67788236
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67726910
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66310796
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63025893
49* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62733135
50* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60747546
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60379585
52GATA1_22025678_ChIP-Seq_K562_Human1.56461610
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54680105
54* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53753741
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52731665
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.51077660
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50230009
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48013245
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.47683043
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45029298
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42805449
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42665587
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42416665
64IGF1R_20145208_ChIP-Seq_DFB_Human1.42225989
65ER_23166858_ChIP-Seq_MCF-7_Human1.41596190
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.41460501
67* SPI1_23547873_ChIP-Seq_NB4_Human1.40856766
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40231906
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39745782
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36958622
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.36958622
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36504499
73GBX2_23144817_ChIP-Seq_PC3_Human1.36212797
74RUNX_20019798_ChIP-Seq_JUKART_Human1.35964680
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35527481
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34885773
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34744826
78* NANOG_19829295_ChIP-Seq_ESCs_Human1.32288571
79* SOX2_19829295_ChIP-Seq_ESCs_Human1.32288571
80P300_19829295_ChIP-Seq_ESCs_Human1.32012144
81MYB_26560356_Chip-Seq_TH2_Human1.31876948
82BCAT_22108803_ChIP-Seq_LS180_Human1.30550963
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29329731
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28509433
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.26534395
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26211666
87VDR_23849224_ChIP-Seq_CD4+_Human1.25982203
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24226048
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21373225
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.21337328
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20456151
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20332608
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19869924
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19409376
95HTT_18923047_ChIP-ChIP_STHdh_Human1.18589832
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18233582
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18070959
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16663439
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16648444
100EWS_26573619_Chip-Seq_HEK293_Human1.16591530
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16569430
102* DCP1A_22483619_ChIP-Seq_HELA_Human1.16339952
103SCL_19346495_ChIP-Seq_HPC-7_Human1.15089487
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.13888716
105TAF15_26573619_Chip-Seq_HEK293_Human1.13559773
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13559274
107TP53_22573176_ChIP-Seq_HFKS_Human1.13423934
108CDX2_22108803_ChIP-Seq_LS180_Human1.11796223
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10736067
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09785463
111* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09368986
112GATA3_27048872_Chip-Seq_THYMUS_Human1.09316302
113P53_22387025_ChIP-Seq_ESCs_Mouse1.08031298
114VDR_24787735_ChIP-Seq_THP-1_Human1.07253544
115FUS_26573619_Chip-Seq_HEK293_Human1.07234055
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07018404
117CBP_20019798_ChIP-Seq_JUKART_Human1.06936976
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06936976
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06160477
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06120813
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05549276
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05068524
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03860641
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03699046
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03190995
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02773948
127* FOXH1_21741376_ChIP-Seq_EPCs_Human1.02411670
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.99957821
129GATA3_21878914_ChIP-Seq_MCF-7_Human0.98272273
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98016933
131SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97840298
132SMRT_27268052_Chip-Seq_Bcells_Human0.97696307
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97238008
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96948970
135AR_20517297_ChIP-Seq_VCAP_Human0.96639190
136TCF4_22108803_ChIP-Seq_LS180_Human0.96379974
137NCOR_22424771_ChIP-Seq_293T_Human0.96231231
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.96110293
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96104566
140GATA3_26560356_Chip-Seq_TH2_Human0.95913585
141GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95722723
142* SOX2_20726797_ChIP-Seq_SW620_Human0.95633249
143TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95577409
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.95014394
145P300_18555785_Chip-Seq_ESCs_Mouse0.95011656
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.94598530
147PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94550192
148* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93704991
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93079503
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.92241221
151CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90106846
152TFEB_21752829_ChIP-Seq_HELA_Human0.89099323
153BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88227898
154GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87932740
155GABP_19822575_ChIP-Seq_HepG2_Human0.86904833
156CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84295087
157SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83906508
158GATA4_25053715_ChIP-Seq_YYC3_Human0.83410313
159PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83079463
160CTCF_26484167_Chip-Seq_Bcells_Mouse0.83044735
161TRIM28_21343339_ChIP-Seq_HEK293_Human0.82590848
162ELK1_19687146_ChIP-ChIP_HELA_Human0.81889506
163ERG_20517297_ChIP-Seq_VCAP_Human0.81883383
164ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81633064
165STAT1_20625510_ChIP-Seq_HELA_Human0.81466501
166MYC_18555785_ChIP-Seq_MESCs_Mouse0.78691309
167* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78453502
168PU_27001747_Chip-Seq_BMDM_Mouse0.77697619
169NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77150308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.80702024
2MP0002139_abnormal_hepatobiliary_system3.69903152
3MP0003195_calcinosis3.40728694
4MP0003806_abnormal_nucleotide_metabolis3.27601012
5MP0003186_abnormal_redox_activity3.16026554
6MP0004043_abnormal_pH_regulation3.07736696
7MP0005058_abnormal_lysosome_morphology2.88290426
8MP0005332_abnormal_amino_acid2.61347816
9MP0003724_increased_susceptibility_to2.58049242
10MP0001835_abnormal_antigen_presentation2.52940823
11MP0008875_abnormal_xenobiotic_pharmacok2.51095258
12MP0005365_abnormal_bile_salt2.37446378
13MP0009785_altered_susceptibility_to2.33107338
14MP0002138_abnormal_hepatobiliary_system2.32234803
15MP0005075_abnormal_melanosome_morpholog2.30239722
16MP0009643_abnormal_urine_homeostasis2.27467354
17MP0005085_abnormal_gallbladder_physiolo2.22094699
18MP0002837_dystrophic_cardiac_calcinosis2.21589235
19MP0002148_abnormal_hypersensitivity_rea2.17594955
20MP0004019_abnormal_vitamin_homeostasis2.08404092
21MP0009840_abnormal_foam_cell2.04239776
22MP0005636_abnormal_mineral_homeostasis2.04180771
23MP0003436_decreased_susceptibility_to2.00279853
24MP0006036_abnormal_mitochondrial_physio1.97018344
25MP0002277_abnormal_respiratory_mucosa1.96986132
26MP0003191_abnormal_cellular_cholesterol1.82242274
27MP0000685_abnormal_immune_system1.78968310
28MP0002163_abnormal_gland_morphology1.77494803
29MP0002419_abnormal_innate_immunity1.76399003
30MP0005025_abnormal_response_to1.71819546
31MP0004147_increased_porphyrin_level1.71796412
32MP0006082_CNS_inflammation1.64615799
33MP0008469_abnormal_protein_level1.64329183
34MP0003011_delayed_dark_adaptation1.64002494
35MP0005083_abnormal_biliary_tract1.62638655
36MP0003656_abnormal_erythrocyte_physiolo1.61581100
37MP0005584_abnormal_enzyme/coenzyme_acti1.60239629
38MP0005084_abnormal_gallbladder_morpholo1.59020547
39MP0001756_abnormal_urination1.57080896
40MP0005671_abnormal_response_to1.56311332
41MP0005000_abnormal_immune_tolerance1.56270622
42MP0009764_decreased_sensitivity_to1.55699309
43MP0001764_abnormal_homeostasis1.54217252
44MP0001666_abnormal_nutrient_absorption1.51137354
45MP0005319_abnormal_enzyme/_coenzyme1.50859421
46MP0003172_abnormal_lysosome_physiology1.48276066
47MP0005174_abnormal_tail_pigmentation1.45939070
48MP0001765_abnormal_ion_homeostasis1.45320696
49MP0005646_abnormal_pituitary_gland1.45311852
50MP0005387_immune_system_phenotype1.41132640
51MP0001790_abnormal_immune_system1.41132640
52MP0005464_abnormal_platelet_physiology1.40626608
53MP0000569_abnormal_digit_pigmentation1.39814308
54MP0003252_abnormal_bile_duct1.36313066
55MP0001853_heart_inflammation1.35138206
56MP0002136_abnormal_kidney_physiology1.34131289
57MP0001845_abnormal_inflammatory_respons1.29600500
58MP0006072_abnormal_retinal_apoptosis1.29441382
59MP0001533_abnormal_skeleton_physiology1.29124216
60MP0000343_altered_response_to1.27884071
61MP0008872_abnormal_physiological_respon1.22956008
62MP0002876_abnormal_thyroid_physiology1.21628953
63MP0005408_hypopigmentation1.21595777
64MP0002723_abnormal_immune_serum1.20367171
65MP0010329_abnormal_lipoprotein_level1.18955089
66MP0000015_abnormal_ear_pigmentation1.18276862
67MP0006054_spinal_hemorrhage1.18089471
68MP0002118_abnormal_lipid_homeostasis1.17114877
69MP0000920_abnormal_myelination1.15365854
70MP0002095_abnormal_skin_pigmentation1.14846397
71MP0002452_abnormal_antigen_presenting1.12901571
72MP0005451_abnormal_body_composition1.12855697
73MP0003183_abnormal_peptide_metabolism1.12719704
74MP0000609_abnormal_liver_physiology1.04776113
75MP0002909_abnormal_adrenal_gland1.04579204
76MP0008260_abnormal_autophagy1.03337496
77MP0000372_irregular_coat_pigmentation1.03119785
78MP0003075_altered_response_to1.01317074
79MP0005551_abnormal_eye_electrophysiolog1.00613758
80MP0000716_abnormal_immune_system0.99631045
81MP0000689_abnormal_spleen_morphology0.98422506
82MP0005253_abnormal_eye_physiology0.97345535
83MP0009763_increased_sensitivity_to0.94518821
84MP0001819_abnormal_immune_cell0.94405657
85MP0002420_abnormal_adaptive_immunity0.93650007
86MP0010155_abnormal_intestine_physiology0.93364371
87MP0001800_abnormal_humoral_immune0.93248887
88MP0005410_abnormal_fertilization0.93238566
89MP0003646_muscle_fatigue0.93169625
90MP0000230_abnormal_systemic_arterial0.91987477
91MP0010386_abnormal_urinary_bladder0.91934121
92MP0003763_abnormal_thymus_physiology0.91586207
93MP0006035_abnormal_mitochondrial_morpho0.87910824
94MP0002933_joint_inflammation0.87526712
95MP0004883_abnormal_blood_vessel0.87525477
96MP0000604_amyloidosis0.86934249
97MP0008877_abnormal_DNA_methylation0.86878464
98MP0001873_stomach_inflammation0.85829878
99MP0001542_abnormal_bone_strength0.85444209
100MP0009642_abnormal_blood_homeostasis0.85012919
101MP0004381_abnormal_hair_follicle0.84784972
102MP0009697_abnormal_copulation0.84490635
103MP0000427_abnormal_hair_cycle0.83842985
104MP0000465_gastrointestinal_hemorrhage0.83825987
105MP0005535_abnormal_body_temperature0.82165397
106MP0005645_abnormal_hypothalamus_physiol0.81297150
107MP0002693_abnormal_pancreas_physiology0.79482381
108MP0005164_abnormal_response_to0.79370849
109MP0002398_abnormal_bone_marrow0.79262037
110MP0003638_abnormal_response/metabolism_0.79198481
111MP0005376_homeostasis/metabolism_phenot0.78983398
112MP0005220_abnormal_exocrine_pancreas0.78905605
113MP0005310_abnormal_salivary_gland0.78710792
114MP0002006_tumorigenesis0.78068010
115MP0009333_abnormal_splenocyte_physiolog0.77392604
116MP0003866_abnormal_defecation0.76405316
117MP0009765_abnormal_xenobiotic_induced0.75782943
118MP0004782_abnormal_surfactant_physiolog0.75612969
119MP0005166_decreased_susceptibility_to0.72883411
120MP0003690_abnormal_glial_cell0.72391072
121MP0002132_abnormal_respiratory_system0.72009532
122MP0002405_respiratory_system_inflammati0.71099136
123MP0005379_endocrine/exocrine_gland_phen0.70596815
124MP0000538_abnormal_urinary_bladder0.70252925
125MP0000598_abnormal_liver_morphology0.70184030
126MP0001986_abnormal_taste_sensitivity0.70160588
127MP0005670_abnormal_white_adipose0.69765244
128MP0002166_altered_tumor_susceptibility0.68829955
129MP0002998_abnormal_bone_remodeling0.68321185

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)4.15238408
2Vacuolated lymphocytes (HP:0001922)3.96766851
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.80549511
4Stomatitis (HP:0010280)3.58916809
5Hepatic necrosis (HP:0002605)3.39245082
6Acute encephalopathy (HP:0006846)3.26975111
7Elevated erythrocyte sedimentation rate (HP:0003565)3.17475177
8Acute necrotizing encephalopathy (HP:0006965)3.16895977
9Abnormality of urine glucose concentration (HP:0011016)3.13729345
10Glycosuria (HP:0003076)3.13729345
11Abnormal mitochondria in muscle tissue (HP:0008316)3.07550540
12Hypokalemic alkalosis (HP:0001949)3.06535518
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.06365484
14Dicarboxylic aciduria (HP:0003215)3.06365484
15Proximal tubulopathy (HP:0000114)3.04882005
16Hepatocellular necrosis (HP:0001404)3.04829027
17Mitochondrial inheritance (HP:0001427)2.99753460
18Abnormality of fatty-acid metabolism (HP:0004359)2.98713264
19Gout (HP:0001997)2.90463850
20Cerebral edema (HP:0002181)2.90223053
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87707067
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87707067
23Abnormality of glycolipid metabolism (HP:0010969)2.86043549
24Abnormality of liposaccharide metabolism (HP:0010968)2.86043549
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.86043549
26Hypoglycemic coma (HP:0001325)2.84357983
27Metabolic alkalosis (HP:0200114)2.77022113
28Methylmalonic acidemia (HP:0002912)2.74651778
29Hypomagnesemia (HP:0002917)2.70421012
30Hyperactive renin-angiotensin system (HP:0000841)2.70061724
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69907215
32Abnormality of magnesium homeostasis (HP:0004921)2.69781517
33Renal Fanconi syndrome (HP:0001994)2.63234887
34Increased CSF lactate (HP:0002490)2.63030275
35Abnormality of macrophages (HP:0004311)2.58821664
36Hyperphosphaturia (HP:0003109)2.51375086
37Abnormality of renal resorption (HP:0011038)2.50168576
38Alkalosis (HP:0001948)2.49859488
39Increased intramyocellular lipid droplets (HP:0012240)2.49847200
40Increased muscle lipid content (HP:0009058)2.49564943
41Pancreatic cysts (HP:0001737)2.49559909
42Lactic acidosis (HP:0003128)2.48049471
43Abnormality of purine metabolism (HP:0004352)2.48040468
44Axonal loss (HP:0003447)2.47085287
45Ketoacidosis (HP:0001993)2.46854032
46Progressive macrocephaly (HP:0004481)2.46435919
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45404801
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.44747092
49Hypoplasia of the fovea (HP:0007750)2.44747092
50Increased circulating renin level (HP:0000848)2.43229730
51Hyperglycinuria (HP:0003108)2.42349836
52Abolished electroretinogram (ERG) (HP:0000550)2.41428298
53Recurrent abscess formation (HP:0002722)2.40816245
54Recurrent bacterial skin infections (HP:0005406)2.39273274
55Ketosis (HP:0001946)2.38285954
56Lethargy (HP:0001254)2.38042166
57IgG deficiency (HP:0004315)2.35872734
58Polyuria (HP:0000103)2.35652532
59Abnormality of chloride homeostasis (HP:0011422)2.35571272
60Abnormal urine output (HP:0012590)2.34480175
61Dysostosis multiplex (HP:0000943)2.34298473
62Abnormality of T cell number (HP:0011839)2.34193537
63Abnormality of renal excretion (HP:0011036)2.32994878
64Myositis (HP:0100614)2.31740123
65T lymphocytopenia (HP:0005403)2.31694009
66Thyroiditis (HP:0100646)2.30938375
67Lipid accumulation in hepatocytes (HP:0006561)2.30562180
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29587052
69Congenital, generalized hypertrichosis (HP:0004540)2.28648335
70Hypoproteinemia (HP:0003075)2.25961477
71Hypothermia (HP:0002045)2.24655474
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24153841
73Abnormality of the fovea (HP:0000493)2.23182608
74Abnormal rod and cone electroretinograms (HP:0008323)2.22770175
75Nausea (HP:0002018)2.22322059
76Vomiting (HP:0002013)2.22272234
77Congenital stationary night blindness (HP:0007642)2.21780253
78Congenital sensorineural hearing impairment (HP:0008527)2.21639618
79Intrahepatic cholestasis (HP:0001406)2.20896813
80Microvesicular hepatic steatosis (HP:0001414)2.20054355
81Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18980436
82Optic neuritis (HP:0100653)2.18484831
83Retrobulbar optic neuritis (HP:0100654)2.18484831
84Increased hepatocellular lipid droplets (HP:0006565)2.18191313
853-Methylglutaconic aciduria (HP:0003535)2.17884594
86Hyperammonemia (HP:0001987)2.17805440
87Petechiae (HP:0000967)2.17170489
88Abnormality of the renal cortex (HP:0011035)2.17166703
89Increased neuronal autofluorescent lipopigment (HP:0002074)2.16842731
90True hermaphroditism (HP:0010459)2.16695716
91Xanthomatosis (HP:0000991)2.16689599
92Metabolic acidosis (HP:0001942)2.15515419
93Methylmalonic aciduria (HP:0012120)2.14891406
94Abnormal urine phosphate concentration (HP:0012599)2.13810333
95Renal cortical cysts (HP:0000803)2.12714243
96Abnormality of glycine metabolism (HP:0010895)2.12548966
97Abnormality of serine family amino acid metabolism (HP:0010894)2.12548966
98Abnormality of vitamin B metabolism (HP:0004340)2.11696269
99Pancreatic fibrosis (HP:0100732)2.11474494
100Molar tooth sign on MRI (HP:0002419)2.09689814
101Abnormality of midbrain morphology (HP:0002418)2.09689814
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09049140
103Vascular calcification (HP:0004934)2.08896217
104Recurrent gram-negative bacterial infections (HP:0005420)2.07094906
105Abnormality of the prostate (HP:0008775)2.06959777
106Orchitis (HP:0100796)2.06779619
107Respiratory failure (HP:0002878)2.06115903
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06081756
109Decreased central vision (HP:0007663)2.04210610
110Reduced antithrombin III activity (HP:0001976)2.03772831
111Large for gestational age (HP:0001520)2.00117977
112Exertional dyspnea (HP:0002875)1.98954614
113Renal tubular dysfunction (HP:0000124)1.98469422
114Recurrent fungal infections (HP:0002841)1.98131963
115Hyperuricemia (HP:0002149)1.97450233
116Increased purine levels (HP:0004368)1.97450233
117Medial flaring of the eyebrow (HP:0010747)1.97141888
118Pulmonary infiltrates (HP:0002113)1.96940343
119Abnormality of renin-angiotensin system (HP:0000847)1.96688322
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96644078
121Spastic paraparesis (HP:0002313)1.96474007
122Attenuation of retinal blood vessels (HP:0007843)1.96199689
123Albinism (HP:0001022)1.96188141
124Exercise intolerance (HP:0003546)1.95724832
125Beaking of vertebral bodies (HP:0004568)1.95437118
126Polydipsia (HP:0001959)1.95363239
127Abnormal drinking behavior (HP:0030082)1.95363239
128Hyperaldosteronism (HP:0000859)1.94820691
129Abnormality of T cells (HP:0002843)1.93782466
130Opisthotonus (HP:0002179)1.93767602
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.93567748
132Absent/shortened dynein arms (HP:0200106)1.93567748
133Increased serum lactate (HP:0002151)1.92760807
134Progressive neurologic deterioration (HP:0002344)1.92565387
135Tetany (HP:0001281)1.92138931
136Recurrent skin infections (HP:0001581)1.91679603
137Abnormal tarsal ossification (HP:0008369)1.91376952
138Abnormality of nucleobase metabolism (HP:0010932)1.90773561
139Abnormality of B cell number (HP:0010975)1.89257425
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88863571
141Abnormality of polysaccharide metabolism (HP:0011012)1.88863571
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88863571
143Abnormal protein glycosylation (HP:0012346)1.87998307
144Abnormal glycosylation (HP:0012345)1.87998307
145Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87998307
146Abnormal protein N-linked glycosylation (HP:0012347)1.87998307
147Mucopolysacchariduria (HP:0008155)1.87968654
148Urinary glycosaminoglycan excretion (HP:0003541)1.87968654
149Renal salt wasting (HP:0000127)1.87164151
150Recurrent bronchitis (HP:0002837)1.86976890
151Type I transferrin isoform profile (HP:0003642)1.86881813
152Chronic mucocutaneous candidiasis (HP:0002728)1.82722090
153Recurrent cutaneous fungal infections (HP:0011370)1.82722090
154Conjunctival hamartoma (HP:0100780)1.82127755
155Obstructive lung disease (HP:0006536)1.78558764
156Chronic obstructive pulmonary disease (HP:0006510)1.78558764
157Aplasia/Hypoplasia of the macula (HP:0008059)1.78272615
158Aplasia/Hypoplasia affecting the retina (HP:0008061)1.77995687
159Hemoptysis (HP:0002105)1.77425823
160Eczematoid dermatitis (HP:0000976)1.75453676
161Abnormality of the vitamin B12 metabolism (HP:0004341)1.74747438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.37386568
2BCKDK3.30423878
3WNK43.01046600
4STK162.91544979
5PIM22.90772801
6PBK2.66292156
7OXSR12.56113492
8MST42.46808816
9IRAK32.45746304
10NUAK12.39487219
11STK392.37830560
12MAP4K22.31725645
13EIF2AK32.27795744
14ERN12.07599994
15ARAF2.03938127
16GRK11.99445834
17MAP3K141.94453244
18IRAK41.94414526
19TBK11.91745899
20EIF2AK11.89857563
21WNK31.69989370
22MYLK1.69947133
23MUSK1.66459969
24TEC1.57992901
25IKBKE1.41009296
26PINK11.37287137
27VRK21.34062187
28GRK61.32544819
29EPHB11.28905557
30IKBKB1.28136476
31FES1.28126702
32KDR1.27114539
33KIT1.25000319
34ERBB31.22692112
35BMPR1B1.22539208
36ABL21.22074874
37MAP3K31.21601074
38MAP3K121.20186424
39TYK21.19903931
40TLK11.16831785
41INSRR1.11950069
42MAPKAPK31.10976529
43NME11.08503791
44TESK21.07761912
45PIK3CG1.07623172
46FLT31.07611856
47ITK1.07150795
48CSK1.04872881
49BLK1.04557946
50IRAK11.02172068
51MAP4K11.01765292
52ADRBK21.01761602
53BTK1.01026818
54TIE10.99924454
55PTK2B0.99608591
56JAK30.99380332
57MAPKAPK50.99125237
58TESK10.98304438
59TAOK30.97358319
60MAP3K110.97304345
61FER0.97118917
62MAPK150.94036817
63TNK20.91452392
64MST1R0.88750459
65ZAP700.88467135
66BUB10.86427510
67MET0.86243315
68MAP2K30.85917324
69CAMKK20.84653916
70ADRBK10.84218587
71TXK0.79529386
72TGFBR20.79169185
73PDK20.77443386
74IRAK20.77279732
75MAP2K60.77202211
76PAK30.76241299
77LIMK10.75782370
78TRPM70.74701915
79PRKG20.73613295
80NEK90.72886911
81RIPK40.71201390
82CSF1R0.70293771
83CDK190.69286245
84LRRK20.66378392
85GRK70.66359631
86JAK10.66093503
87BMPR20.66067882
88BRAF0.66058647
89MARK30.65711503
90TRIM280.65126047
91BRSK20.65099973
92LYN0.64757832
93GRK50.64414589
94STK240.64382894
95PRKCD0.62845769
96NEK10.61178353
97SYK0.60617496
98DAPK20.60373445
99ZAK0.59835221
100FRK0.57435401
101ABL10.56780509
102VRK10.56378887
103PRKCI0.56073922
104LMTK20.54721895
105STK100.53803161
106CAMK2G0.53734019
107PIM10.52272547
108IGF1R0.51944769
109STK38L0.51576257
110CDK80.50888466
111HCK0.50539855
112PLK20.50023473
113MATK0.49520837
114PHKG10.48667225
115PHKG20.48667225
116FGR0.47936853
117ILK0.47585348
118DAPK10.47421281
119TGFBR10.46614869
120EIF2AK20.45308155
121CSNK1G20.44675691
122DAPK30.44660701
123NEK60.44408283
124MAP2K20.43350704
125CSNK1G30.41430082
126LCK0.41024323
127PRKCQ0.40054998
128CAMK2D0.39785577
129RPS6KB20.39692641
130ACVR1B0.37920876
131PIK3CA0.36253680
132MAP3K10.34267066
133RPS6KA50.33964462
134MOS0.33588543
135TNIK0.33114532
136PRKCE0.32392760
137MAPKAPK20.31230230
138NLK0.30939527

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.15005401
2Sulfur metabolism_Homo sapiens_hsa009202.92034172
3Oxidative phosphorylation_Homo sapiens_hsa001902.66864166
4Autoimmune thyroid disease_Homo sapiens_hsa053202.43359294
5Type I diabetes mellitus_Homo sapiens_hsa049402.42439139
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39184147
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26106267
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17539281
9Parkinsons disease_Homo sapiens_hsa050122.15184410
10Peroxisome_Homo sapiens_hsa041462.09790591
11Folate biosynthesis_Homo sapiens_hsa007902.08041961
12Proteasome_Homo sapiens_hsa030501.99723058
13Fatty acid elongation_Homo sapiens_hsa000621.96492678
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87670715
15Propanoate metabolism_Homo sapiens_hsa006401.80782395
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77642776
17Primary immunodeficiency_Homo sapiens_hsa053401.74505344
18Other glycan degradation_Homo sapiens_hsa005111.67701389
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67079691
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65458809
21Histidine metabolism_Homo sapiens_hsa003401.64884856
22Fatty acid degradation_Homo sapiens_hsa000711.64350069
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63659362
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63237831
25Ribosome_Homo sapiens_hsa030101.61381719
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59375661
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58916186
28Butanoate metabolism_Homo sapiens_hsa006501.55600047
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55385617
30Glutathione metabolism_Homo sapiens_hsa004801.55276767
31Antigen processing and presentation_Homo sapiens_hsa046121.50651744
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.48826378
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48618856
34Hematopoietic cell lineage_Homo sapiens_hsa046401.44570146
35Alzheimers disease_Homo sapiens_hsa050101.44374537
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.43018674
37Tryptophan metabolism_Homo sapiens_hsa003801.42688259
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39458848
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33465837
40Steroid biosynthesis_Homo sapiens_hsa001001.33395246
41Lysosome_Homo sapiens_hsa041421.32416362
42Chemical carcinogenesis_Homo sapiens_hsa052041.31951437
43Pyruvate metabolism_Homo sapiens_hsa006201.30624575
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30288836
45Huntingtons disease_Homo sapiens_hsa050161.19738952
46Sulfur relay system_Homo sapiens_hsa041221.19558278
47beta-Alanine metabolism_Homo sapiens_hsa004101.19101262
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14264756
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.12698664
50Vitamin digestion and absorption_Homo sapiens_hsa049771.12698177
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10911410
52Leishmaniasis_Homo sapiens_hsa051401.10783187
53Fatty acid metabolism_Homo sapiens_hsa012121.09327280
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09108730
55Arginine and proline metabolism_Homo sapiens_hsa003301.08798120
56Carbon metabolism_Homo sapiens_hsa012001.08115334
57Starch and sucrose metabolism_Homo sapiens_hsa005001.04884146
58Nitrogen metabolism_Homo sapiens_hsa009101.04046212
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02129172
60Arachidonic acid metabolism_Homo sapiens_hsa005901.00153648
61Rheumatoid arthritis_Homo sapiens_hsa053230.99420222
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.98529248
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97622140
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96949167
65Phenylalanine metabolism_Homo sapiens_hsa003600.96755134
66Collecting duct acid secretion_Homo sapiens_hsa049660.96584315
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95934742
68Selenocompound metabolism_Homo sapiens_hsa004500.94987069
69Pentose phosphate pathway_Homo sapiens_hsa000300.93079302
70Phototransduction_Homo sapiens_hsa047440.92159054
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91116353
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.90828656
73Retinol metabolism_Homo sapiens_hsa008300.89915037
74Staphylococcus aureus infection_Homo sapiens_hsa051500.89078186
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88768994
76Metabolic pathways_Homo sapiens_hsa011000.88464726
77Caffeine metabolism_Homo sapiens_hsa002320.85806195
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85559028
79Fructose and mannose metabolism_Homo sapiens_hsa000510.84793962
80PPAR signaling pathway_Homo sapiens_hsa033200.84266288
81Sphingolipid metabolism_Homo sapiens_hsa006000.81716979
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80181871
83Legionellosis_Homo sapiens_hsa051340.80064801
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74623827
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74606768
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74521331
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.73810113
88Regulation of autophagy_Homo sapiens_hsa041400.73138187
89Complement and coagulation cascades_Homo sapiens_hsa046100.73118361
90Phagosome_Homo sapiens_hsa041450.72745171
91Tyrosine metabolism_Homo sapiens_hsa003500.72297352
92Tuberculosis_Homo sapiens_hsa051520.72190946
93Vibrio cholerae infection_Homo sapiens_hsa051100.71726928
94Linoleic acid metabolism_Homo sapiens_hsa005910.71110325
95Galactose metabolism_Homo sapiens_hsa000520.70865531
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70845989
97Allograft rejection_Homo sapiens_hsa053300.70585015
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69184426
99Graft-versus-host disease_Homo sapiens_hsa053320.67300906
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66340960
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66182867
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.65552307
103Pyrimidine metabolism_Homo sapiens_hsa002400.63280543
104Homologous recombination_Homo sapiens_hsa034400.61412210
105Malaria_Homo sapiens_hsa051440.60685897
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60377101
107N-Glycan biosynthesis_Homo sapiens_hsa005100.59217341
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58945874
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.58471137
110Renin-angiotensin system_Homo sapiens_hsa046140.58009382
111Cardiac muscle contraction_Homo sapiens_hsa042600.56054698
112Biosynthesis of amino acids_Homo sapiens_hsa012300.55608031
113Viral myocarditis_Homo sapiens_hsa054160.54610446
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.53366283
115RNA degradation_Homo sapiens_hsa030180.52696342
116ABC transporters_Homo sapiens_hsa020100.51383088
117Glycerolipid metabolism_Homo sapiens_hsa005610.51376067
118Osteoclast differentiation_Homo sapiens_hsa043800.50090609
119Arginine biosynthesis_Homo sapiens_hsa002200.49245690
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49087149
121Mineral absorption_Homo sapiens_hsa049780.48434441
122RNA polymerase_Homo sapiens_hsa030200.48169300
123Pertussis_Homo sapiens_hsa051330.47338209
124Ether lipid metabolism_Homo sapiens_hsa005650.47329155
125Measles_Homo sapiens_hsa051620.45891885
126Fat digestion and absorption_Homo sapiens_hsa049750.44617619
127Asthma_Homo sapiens_hsa053100.44481924
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42142488
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.37380376
130Herpes simplex infection_Homo sapiens_hsa051680.35775979
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35559330

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