TMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.30639827
2multicellular organism reproduction (GO:0032504)9.28878630
3fusion of sperm to egg plasma membrane (GO:0007342)8.72185544
4reproduction (GO:0000003)7.31544944
5acrosome reaction (GO:0007340)7.14969486
6behavioral response to nicotine (GO:0035095)6.99745143
7motile cilium assembly (GO:0044458)6.67942906
8adenine nucleotide transport (GO:0051503)6.60073962
9plasma membrane fusion (GO:0045026)6.56151364
10acrosome assembly (GO:0001675)6.43084861
11sperm-egg recognition (GO:0035036)6.41114073
12purine ribonucleotide transport (GO:0015868)6.23940234
13centriole assembly (GO:0098534)5.95768967
14bone trabecula formation (GO:0060346)5.87367579
15cell-cell recognition (GO:0009988)5.79027722
16axonemal dynein complex assembly (GO:0070286)5.73568179
17purine nucleotide transport (GO:0015865)5.62456194
18positive regulation of hair cycle (GO:0042635)5.55345628
19positive regulation of hair follicle development (GO:0051798)5.55345628
20single fertilization (GO:0007338)5.39947843
21piRNA metabolic process (GO:0034587)5.39821354
22microtubule depolymerization (GO:0007019)5.39066392
23epithelial cilium movement (GO:0003351)5.27793230
24sperm motility (GO:0030317)5.23281896
25positive regulation of fibroblast migration (GO:0010763)5.14317238
26cilium movement (GO:0003341)4.57191365
27activated T cell proliferation (GO:0050798)4.37261266
28response to parathyroid hormone (GO:0071107)4.35847072
29spermatid nucleus differentiation (GO:0007289)4.33316776
30male meiosis (GO:0007140)4.23915841
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.22789268
32sensory perception of taste (GO:0050909)4.20917517
33regulation of hair follicle development (GO:0051797)4.20864832
34DNA methylation involved in gamete generation (GO:0043046)4.20649675
35binding of sperm to zona pellucida (GO:0007339)4.05441784
36superoxide anion generation (GO:0042554)4.03649982
37meiotic chromosome segregation (GO:0045132)3.98089220
38startle response (GO:0001964)3.97443851
39regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.91955604
40fertilization (GO:0009566)3.88745836
41regulation of RIG-I signaling pathway (GO:0039535)3.87965326
42opioid receptor signaling pathway (GO:0038003)3.85137637
43glycine transport (GO:0015816)3.85078356
44histone H2B ubiquitination (GO:0033523)3.84616511
45spermatid development (GO:0007286)3.82388535
46calcium ion-dependent exocytosis (GO:0017156)3.81623889
47response to pheromone (GO:0019236)3.71776346
48L-fucose catabolic process (GO:0042355)3.68247707
49fucose catabolic process (GO:0019317)3.68247707
50L-fucose metabolic process (GO:0042354)3.68247707
51positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.60408571
52positive regulation of cell cycle G2/M phase transition (GO:1902751)3.60408571
53phosphatidylinositol acyl-chain remodeling (GO:0036149)3.60191677
54sperm capacitation (GO:0048240)3.59453052
55L-amino acid import (GO:0043092)3.57243257
56glycerophospholipid catabolic process (GO:0046475)3.51624385
57righting reflex (GO:0060013)3.44804800
58phosphatidylserine acyl-chain remodeling (GO:0036150)3.44748102
59synaptic transmission, cholinergic (GO:0007271)3.40130110
60kidney morphogenesis (GO:0060993)3.37401029
61nucleotide transport (GO:0006862)3.36531647
62positive regulation of prostaglandin secretion (GO:0032308)3.33730804
63detection of light stimulus involved in sensory perception (GO:0050962)3.33369945
64detection of light stimulus involved in visual perception (GO:0050908)3.33369945
65axoneme assembly (GO:0035082)3.31974160
66indolalkylamine metabolic process (GO:0006586)3.31042408
67protein neddylation (GO:0045116)3.30641742
68cornea development in camera-type eye (GO:0061303)3.26393920
69response to water (GO:0009415)3.25906495
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25738475
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.25738475
72NADH dehydrogenase complex assembly (GO:0010257)3.25738475
73protein-cofactor linkage (GO:0018065)3.23523755
74positive regulation of fatty acid transport (GO:2000193)3.22423518
75regulation of hair cycle (GO:0042634)3.22323527
76parturition (GO:0007567)3.21686206
77notochord development (GO:0030903)3.16057785
78cranial nerve morphogenesis (GO:0021602)3.15772606
79cell recognition (GO:0008037)3.15670098
80detection of calcium ion (GO:0005513)3.15486299
81phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.11737639
82kynurenine metabolic process (GO:0070189)3.08757660
83primary amino compound metabolic process (GO:1901160)3.07990821
84response to dietary excess (GO:0002021)3.07637200
85microtubule polymerization or depolymerization (GO:0031109)3.06129650
86synapsis (GO:0007129)3.05799879
87indole-containing compound catabolic process (GO:0042436)3.03649699
88indolalkylamine catabolic process (GO:0046218)3.03649699
89tryptophan catabolic process (GO:0006569)3.03649699
90phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.02380456
91protein polyglutamylation (GO:0018095)3.00283035
92regulation of hippo signaling (GO:0035330)2.99157749
93neuronal action potential (GO:0019228)2.98140660
94protein complex biogenesis (GO:0070271)2.96746677
95platelet dense granule organization (GO:0060155)2.95802140
96regulation of action potential (GO:0098900)2.93859506
97regulation of non-canonical Wnt signaling pathway (GO:2000050)2.93376665
98pyrimidine nucleobase catabolic process (GO:0006208)2.93139279
99DNA deamination (GO:0045006)2.90159343
100rhodopsin mediated signaling pathway (GO:0016056)2.88562772
101serotonin metabolic process (GO:0042428)2.86538021
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86362986
103ventricular system development (GO:0021591)2.86020637
104positive regulation of icosanoid secretion (GO:0032305)2.85092906
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83052320
106indole-containing compound metabolic process (GO:0042430)2.82597263
107behavioral response to ethanol (GO:0048149)2.81070744
108spermatogenesis (GO:0007283)2.80811220
109male gamete generation (GO:0048232)2.80739331
110nonmotile primary cilium assembly (GO:0035058)2.80219331
111eosinophil chemotaxis (GO:0048245)2.77043973
112mitochondrial respiratory chain complex assembly (GO:0033108)2.76895236
113regulation of cilium movement (GO:0003352)2.76244930
114water-soluble vitamin biosynthetic process (GO:0042364)2.75309861
115regulation of rhodopsin mediated signaling pathway (GO:0022400)2.74907350
116synaptonemal complex organization (GO:0070193)2.73289523
117positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.72977641
118NAD biosynthetic process (GO:0009435)2.71848160
119nucleoside transport (GO:0015858)2.69128496
120cellular ketone body metabolic process (GO:0046950)2.69110177
121negative regulation of reactive oxygen species metabolic process (GO:2000378)2.68757282
122preassembly of GPI anchor in ER membrane (GO:0016254)2.67384875
123respiratory chain complex IV assembly (GO:0008535)2.66729974
124chromosome organization involved in meiosis (GO:0070192)2.64809904
125cilium morphogenesis (GO:0060271)2.64016615
126smoothened signaling pathway (GO:0007224)2.63716100
127gamete generation (GO:0007276)2.63382899
128regulation of microtubule-based movement (GO:0060632)2.62971563
129photoreceptor cell maintenance (GO:0045494)2.61786678
130hematopoietic stem cell proliferation (GO:0071425)2.61504660
131cellular response to vitamin D (GO:0071305)2.61209983
132regulation of fibroblast migration (GO:0010762)2.60731129
133dopamine transport (GO:0015872)2.59929768
134* detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58251623
135G-protein coupled receptor internalization (GO:0002031)2.56434612
136nephron epithelium morphogenesis (GO:0072088)2.55894624
137nephron tubule morphogenesis (GO:0072078)2.55894624
138regulation of neurotransmitter uptake (GO:0051580)2.55871687
139phosphatidylcholine acyl-chain remodeling (GO:0036151)2.55584208
140myoblast fusion (GO:0007520)2.55223470
141transmission of nerve impulse (GO:0019226)2.55211684
142synaptonemal complex assembly (GO:0007130)2.55150490
143regulation of prostaglandin secretion (GO:0032306)2.54959359
144centriole replication (GO:0007099)2.53257858
145photoreceptor cell development (GO:0042461)2.52004833
146membrane depolarization during action potential (GO:0086010)2.50468390
147amine catabolic process (GO:0009310)2.50069134
148cellular biogenic amine catabolic process (GO:0042402)2.50069134
149tryptophan metabolic process (GO:0006568)2.49392998
150amino acid import (GO:0043090)2.49176607
151positive regulation of oligodendrocyte differentiation (GO:0048714)2.48182992
152cilium organization (GO:0044782)2.46991234
153ketone body metabolic process (GO:1902224)2.46880357
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45097821
155anterograde synaptic vesicle transport (GO:0048490)2.44931813
156nucleobase catabolic process (GO:0046113)2.44673390
157male meiosis I (GO:0007141)2.44442103
158sulfation (GO:0051923)2.44286732
159regulation of nuclear cell cycle DNA replication (GO:0033262)2.44223226
160negative regulation of telomere maintenance (GO:0032205)2.44151864
161cilium assembly (GO:0042384)2.42938081
162left/right axis specification (GO:0070986)2.42878147
163regulation of telomere maintenance (GO:0032204)2.42041391
164negative regulation of mast cell activation (GO:0033004)2.41689159
165neuronal action potential propagation (GO:0019227)2.41418609
166intraciliary transport (GO:0042073)2.41325301
167ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.40572835
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.39676477
169extracellular negative regulation of signal transduction (GO:1900116)2.39340190
170extracellular regulation of signal transduction (GO:1900115)2.39340190
171action potential (GO:0001508)2.39253607
172eosinophil migration (GO:0072677)2.35231488
173* reflex (GO:0060004)2.35079373
174regulation of meiosis I (GO:0060631)2.34510800
175vocalization behavior (GO:0071625)2.33654955
176protein localization to cilium (GO:0061512)2.33267222
177female gonad development (GO:0008585)2.31812038
178skeletal muscle fiber development (GO:0048741)2.30535805
179positive regulation of DNA-templated transcription, initiation (GO:2000144)2.30472176
180autophagic vacuole fusion (GO:0000046)2.29876412
181meiotic cell cycle (GO:0051321)2.29076278
182cellular process involved in reproduction in multicellular organism (GO:0022412)2.29043374
183cell wall macromolecule catabolic process (GO:0016998)10.0407830
184cell wall macromolecule metabolic process (GO:0044036)10.0407830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.02385589
2ZNF274_21170338_ChIP-Seq_K562_Hela3.71109826
3EZH2_22144423_ChIP-Seq_EOC_Human3.35651926
4GBX2_23144817_ChIP-Seq_PC3_Human2.99862551
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.92592885
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.88566032
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71336323
8PCGF2_27294783_Chip-Seq_NPCs_Mouse2.62016546
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59386852
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54369355
11SUZ12_27294783_Chip-Seq_NPCs_Mouse2.42594871
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.40102097
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.20668189
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16521484
15KDM2B_26808549_Chip-Seq_REH_Human2.00237250
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99435753
17EZH2_27294783_Chip-Seq_NPCs_Mouse1.98546512
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94173909
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91354350
20EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.91043479
21TAF15_26573619_Chip-Seq_HEK293_Human1.90324374
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.89803870
23EWS_26573619_Chip-Seq_HEK293_Human1.87754510
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87176833
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84429959
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82803740
27* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.82473481
28SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82209399
29P53_22387025_ChIP-Seq_ESCs_Mouse1.81121126
30CMYC_18555785_Chip-Seq_ESCs_Mouse1.80927398
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77710656
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73825407
33STAT3_18555785_Chip-Seq_ESCs_Mouse1.73267913
34BCAT_22108803_ChIP-Seq_LS180_Human1.72070483
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70491416
36EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.70452654
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.69402583
38P300_18555785_Chip-Seq_ESCs_Mouse1.68291750
39IRF1_19129219_ChIP-ChIP_H3396_Human1.66979106
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.66286655
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63655939
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.61019923
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60427380
44NMYC_18555785_Chip-Seq_ESCs_Mouse1.59593535
45CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.59036784
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56503279
47SOX2_18555785_Chip-Seq_ESCs_Mouse1.54187860
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53668087
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53295485
50TP53_22573176_ChIP-Seq_HFKS_Human1.52834976
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52786233
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.52396589
53RUNX1_27457419_Chip-Seq_LIVER_Mouse1.52395100
54KLF4_18555785_Chip-Seq_ESCs_Mouse1.51162530
55PU1_27457419_Chip-Seq_LIVER_Mouse1.50269454
56VDR_22108803_ChIP-Seq_LS180_Human1.49723607
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49301875
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49301875
59* AR_25329375_ChIP-Seq_VCAP_Human1.48647911
60ESRRB_18555785_Chip-Seq_ESCs_Mouse1.48089047
61OCT4_21477851_ChIP-Seq_ESCs_Mouse1.47472367
62SMAD1_18555785_Chip-Seq_ESCs_Mouse1.46013386
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45615904
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.44885256
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44640781
66CTCF_18555785_Chip-Seq_ESCs_Mouse1.44272439
67IGF1R_20145208_ChIP-Seq_DFB_Human1.43781359
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42339530
69CBP_20019798_ChIP-Seq_JUKART_Human1.42339530
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42213106
71* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41006753
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40329821
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.39530752
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38999382
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36924058
76SMAD4_21799915_ChIP-Seq_A2780_Human1.36699226
77ZFX_18555785_Chip-Seq_ESCs_Mouse1.36430930
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36337886
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36224200
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35108658
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34854290
82MYC_18940864_ChIP-ChIP_HL60_Human1.33551320
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32352174
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32104330
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.30303108
86FUS_26573619_Chip-Seq_HEK293_Human1.29558525
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29488355
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.29140687
89* REST_21632747_ChIP-Seq_MESCs_Mouse1.28535978
90TCF4_22108803_ChIP-Seq_LS180_Human1.27361974
91* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27177149
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26549976
93* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26473989
94* FOXA1_25329375_ChIP-Seq_VCAP_Human1.26473989
95P300_19829295_ChIP-Seq_ESCs_Human1.25770141
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25629260
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25228704
98AR_21572438_ChIP-Seq_LNCaP_Human1.24779120
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24670979
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.24051261
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23429234
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23349286
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.22372144
104* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21520933
105CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21135309
106* REST_18959480_ChIP-ChIP_MESCs_Mouse1.20967273
107NCOR_22424771_ChIP-Seq_293T_Human1.20911785
108HOXB7_26014856_ChIP-Seq_BT474_Human1.20333221
109STAT3_23295773_ChIP-Seq_U87_Human1.19763970
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19411247
111SOX2_19829295_ChIP-Seq_ESCs_Human1.19378189
112NANOG_19829295_ChIP-Seq_ESCs_Human1.19378189
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18520465
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18356223
115RNF2_27304074_Chip-Seq_NSC_Mouse1.18249420
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.18060447
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16559112
118ER_23166858_ChIP-Seq_MCF-7_Human1.16532508
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16506115
120ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14793606
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14741708
122* TCF4_23295773_ChIP-Seq_U87_Human1.13804632
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.13472880
124STAT1_17558387_ChIP-Seq_HELA_Human1.13286407
125GABP_17652178_ChIP-ChIP_JURKAT_Human1.12935557
126SALL1_21062744_ChIP-ChIP_HESCs_Human1.12557542
127TP53_18474530_ChIP-ChIP_U2OS_Human1.11922036
128EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10740117
129RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10740117
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.10100329
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08706388
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08139878
133TP63_17297297_ChIP-ChIP_HaCaT_Human1.08058758
134RNF2_27304074_Chip-Seq_ESCs_Mouse1.07936066
135* RUNX2_22187159_ChIP-Seq_PCA_Human1.07410965
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07272711
137* AR_20517297_ChIP-Seq_VCAP_Human1.07120305
138GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06995116
139FOXH1_21741376_ChIP-Seq_EPCs_Human1.05755970
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05410039
141EZH2_27304074_Chip-Seq_ESCs_Mouse1.05296897
142FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04237288
143NANOG_20526341_ChIP-Seq_ESCs_Human1.03995848
144MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03734415
145ERA_21632823_ChIP-Seq_H3396_Human1.03607254
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03419711
147* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02871868
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.02101466
149HTT_18923047_ChIP-ChIP_STHdh_Human1.01786851
150DROSHA_22980978_ChIP-Seq_HELA_Human1.01232181
151* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99195936
152MYC_19829295_ChIP-Seq_ESCs_Human0.98427626
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98141488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.92012844
2MP0000566_synostosis4.08136279
3MP0001188_hyperpigmentation2.92225026
4MP0003136_yellow_coat_color2.83967159
5MP0004484_altered_response_of2.73583028
6MP0003698_abnormal_male_reproductive2.72224838
7MP0003195_calcinosis2.64345573
8MP0008877_abnormal_DNA_methylation2.56740620
9* MP0002102_abnormal_ear_morphology2.49099754
10MP0005409_darkened_coat_color2.47811370
11MP0003879_abnormal_hair_cell2.35642629
12MP0005623_abnormal_meninges_morphology2.34904806
13MP0002735_abnormal_chemical_nociception2.30143692
14MP0006292_abnormal_olfactory_placode2.28228687
15MP0002837_dystrophic_cardiac_calcinosis2.25601002
16MP0001986_abnormal_taste_sensitivity2.21076916
17MP0001486_abnormal_startle_reflex2.20625990
18MP0009046_muscle_twitch2.17781843
19MP0001929_abnormal_gametogenesis2.16999572
20MP0000678_abnormal_parathyroid_gland2.12209359
21MP0002638_abnormal_pupillary_reflex2.08288721
22MP0002163_abnormal_gland_morphology2.06350140
23MP0008872_abnormal_physiological_respon2.04208479
24MP0000579_abnormal_nail_morphology2.00727104
25MP0001968_abnormal_touch/_nociception2.00192266
26MP0008875_abnormal_xenobiotic_pharmacok1.94866206
27MP0004133_heterotaxia1.94166815
28MP0004742_abnormal_vestibular_system1.94053208
29MP0010386_abnormal_urinary_bladder1.93964195
30MP0008057_abnormal_DNA_replication1.90505560
31MP0004885_abnormal_endolymph1.89933961
32MP0005645_abnormal_hypothalamus_physiol1.89716378
33MP0001485_abnormal_pinna_reflex1.83763050
34MP0002876_abnormal_thyroid_physiology1.82278542
35MP0002210_abnormal_sex_determination1.80509195
36MP0008775_abnormal_heart_ventricle1.79602020
37MP0004142_abnormal_muscle_tone1.75297072
38* MP0001963_abnormal_hearing_physiology1.70401123
39* MP0000026_abnormal_inner_ear1.67575065
40MP0002733_abnormal_thermal_nociception1.66379658
41MP0009764_decreased_sensitivity_to1.65902857
42MP0002653_abnormal_ependyma_morphology1.65518760
43MP0002736_abnormal_nociception_after1.64282724
44MP0001501_abnormal_sleep_pattern1.61908917
45MP0003011_delayed_dark_adaptation1.60832186
46MP0000631_abnormal_neuroendocrine_gland1.59001153
47MP0002234_abnormal_pharynx_morphology1.57434265
48MP0009785_altered_susceptibility_to1.57380080
49MP0005451_abnormal_body_composition1.56100016
50MP0000427_abnormal_hair_cycle1.56074687
51MP0000372_irregular_coat_pigmentation1.52160022
52MP0005379_endocrine/exocrine_gland_phen1.50955218
53MP0002067_abnormal_sensory_capabilities1.47362627
54MP0002161_abnormal_fertility/fecundity1.44645763
55MP0005646_abnormal_pituitary_gland1.44069218
56MP0001529_abnormal_vocalization1.40766822
57MP0002249_abnormal_larynx_morphology1.40687014
58MP0003787_abnormal_imprinting1.39886856
59MP0001145_abnormal_male_reproductive1.37912185
60MP0005377_hearing/vestibular/ear_phenot1.34585889
61MP0003878_abnormal_ear_physiology1.34585889
62MP0004145_abnormal_muscle_electrophysio1.34438910
63MP0005423_abnormal_somatic_nervous1.33934634
64MP0000569_abnormal_digit_pigmentation1.33103402
65MP0002938_white_spotting1.32480695
66MP0001790_abnormal_immune_system1.32062105
67MP0005387_immune_system_phenotype1.32062105
68MP0004147_increased_porphyrin_level1.31868136
69MP0006072_abnormal_retinal_apoptosis1.30124144
70MP0000653_abnormal_sex_gland1.29627585
71MP0005386_behavior/neurological_phenoty1.28377055
72MP0004924_abnormal_behavior1.28377055
73MP0000778_abnormal_nervous_system1.26966024
74MP0003880_abnormal_central_pattern1.24918934
75MP0002168_other_aberrant_phenotype1.24876901
76MP0005167_abnormal_blood-brain_barrier1.23666353
77MP0009745_abnormal_behavioral_response1.23471597
78MP0003941_abnormal_skin_development1.23255283
79MP0002909_abnormal_adrenal_gland1.23165090
80MP0002160_abnormal_reproductive_system1.22668645
81MP0000490_abnormal_crypts_of1.21940288
82MP0000230_abnormal_systemic_arterial1.20681039
83MP0000383_abnormal_hair_follicle1.19786292
84MP0003121_genomic_imprinting1.19498316
85MP0008789_abnormal_olfactory_epithelium1.17232041
86MP0005389_reproductive_system_phenotype1.14909329
87MP0000343_altered_response_to1.14354788
88MP0002734_abnormal_mechanical_nocicepti1.14246403
89MP0005195_abnormal_posterior_eye1.13480394
90MP0003635_abnormal_synaptic_transmissio1.11208191
91MP0002282_abnormal_trachea_morphology1.09750495
92MP0001727_abnormal_embryo_implantation1.05664148
93MP0002557_abnormal_social/conspecific_i1.04727567
94MP0004036_abnormal_muscle_relaxation1.01776919
95MP0003718_maternal_effect0.99132024
96MP0003938_abnormal_ear_development0.98732377
97MP0001502_abnormal_circadian_rhythm0.97570181
98MP0002064_seizures0.97504855
99MP0004859_abnormal_synaptic_plasticity0.97455450
100MP0002572_abnormal_emotion/affect_behav0.96169403
101MP0002063_abnormal_learning/memory/cond0.93489115
102MP0003890_abnormal_embryonic-extraembry0.93415159
103MP0001440_abnormal_grooming_behavior0.92498165
104MP0001905_abnormal_dopamine_level0.92386339
105MP0004782_abnormal_surfactant_physiolog0.90932705
106MP0005084_abnormal_gallbladder_morpholo0.90222362
107MP0001984_abnormal_olfaction0.90025898
108MP0004215_abnormal_myocardial_fiber0.89233796
109MP0005448_abnormal_energy_balance0.88083049
110MP0002184_abnormal_innervation0.88032294
111MP0005647_abnormal_sex_gland0.85830555
112MP0002229_neurodegeneration0.84805489
113MP0006276_abnormal_autonomic_nervous0.84358732
114MP0002272_abnormal_nervous_system0.84009300
115MP0002148_abnormal_hypersensitivity_rea0.83696742
116MP0000049_abnormal_middle_ear0.83256084
117MP0001346_abnormal_lacrimal_gland0.83134649
118MP0003646_muscle_fatigue0.82907044
119MP0003122_maternal_imprinting0.82044984
120MP0005551_abnormal_eye_electrophysiolog0.81568772
121MP0000015_abnormal_ear_pigmentation0.81150708
122MP0000462_abnormal_digestive_system0.80717495
123MP0002419_abnormal_innate_immunity0.80435209
124MP0003137_abnormal_impulse_conducting0.78883056
125MP0005253_abnormal_eye_physiology0.78505781
126MP0008995_early_reproductive_senescence0.77174258
127MP0009384_cardiac_valve_regurgitation0.76856794
128MP0001765_abnormal_ion_homeostasis0.75744733
129MP0009697_abnormal_copulation0.75693554
130MP0008260_abnormal_autophagy0.75581574
131MP0003119_abnormal_digestive_system0.75292729
132MP0001764_abnormal_homeostasis0.74821252
133MP0005499_abnormal_olfactory_system0.74674281
134MP0005394_taste/olfaction_phenotype0.74674281
135MP0004019_abnormal_vitamin_homeostasis0.74570835
136MP0004085_abnormal_heartbeat0.73997531
137MP0004043_abnormal_pH_regulation0.70929058
138MP0000538_abnormal_urinary_bladder0.70695688
139MP0002277_abnormal_respiratory_mucosa0.70545156
140MP0004233_abnormal_muscle_weight0.70376047
141MP0006082_CNS_inflammation0.69570689
142MP0001835_abnormal_antigen_presentation0.68003705
143* MP0002752_abnormal_somatic_nervous0.67434882
144MP0004510_myositis0.67136302
145MP0000681_abnormal_thyroid_gland0.65016883
146MP0004858_abnormal_nervous_system0.63600425
147MP0001970_abnormal_pain_threshold0.62736614
148MP0005503_abnormal_tendon_morphology0.61149301
149MP0001119_abnormal_female_reproductive0.60347306
150MP0005025_abnormal_response_to0.59486728
151MP0003183_abnormal_peptide_metabolism0.59282284

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.42323182
2Absent/shortened dynein arms (HP:0200106)7.65483275
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.65483275
4Abnormal respiratory motile cilium physiology (HP:0012261)5.66495811
5Abnormal respiratory motile cilium morphology (HP:0005938)5.64434582
6Abnormal respiratory epithelium morphology (HP:0012253)5.64434582
7Oligodactyly (hands) (HP:0001180)5.26493799
8Tetany (HP:0001281)5.23850340
9Abnormal ciliary motility (HP:0012262)5.11869453
10Split foot (HP:0001839)4.83030390
11Pancreatic cysts (HP:0001737)4.61490186
12Pancreatic fibrosis (HP:0100732)4.41180575
13Rhinitis (HP:0012384)4.34203347
14Molar tooth sign on MRI (HP:0002419)4.11319513
15Abnormality of midbrain morphology (HP:0002418)4.11319513
16True hermaphroditism (HP:0010459)3.91737096
17Severe visual impairment (HP:0001141)3.86054611
18Congenital stationary night blindness (HP:0007642)3.78720749
19Pendular nystagmus (HP:0012043)3.64038281
20Oligodactyly (HP:0012165)3.43486774
21Type II lissencephaly (HP:0007260)3.36230354
22Hyperventilation (HP:0002883)3.33715525
23Absent hand (HP:0004050)3.31944184
24Panhypogammaglobulinemia (HP:0003139)3.24127711
25Abnormality of the renal cortex (HP:0011035)3.22322353
26Chronic bronchitis (HP:0004469)3.18480824
27Nasal polyposis (HP:0100582)3.15180660
28Hyperphosphatemia (HP:0002905)3.14774819
29Abnormality of macular pigmentation (HP:0008002)3.02608641
30Chronic hepatic failure (HP:0100626)3.00184888
31Febrile seizures (HP:0002373)2.98641370
32Abolished electroretinogram (ERG) (HP:0000550)2.97555533
33Tubular atrophy (HP:0000092)2.96377676
34Decreased central vision (HP:0007663)2.95700624
35Medial flaring of the eyebrow (HP:0010747)2.90103277
36Hypomagnesemia (HP:0002917)2.78584486
37Cystic liver disease (HP:0006706)2.78551106
38Type 2 muscle fiber atrophy (HP:0003554)2.73126894
39Upper limb muscle weakness (HP:0003484)2.69657317
40Gait imbalance (HP:0002141)2.68429659
41Attenuation of retinal blood vessels (HP:0007843)2.64334636
42Recurrent sinusitis (HP:0011108)2.61808569
43Increased circulating renin level (HP:0000848)2.61348845
44Increased corneal curvature (HP:0100692)2.60259001
45Keratoconus (HP:0000563)2.60259001
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.60141203
47Congenital primary aphakia (HP:0007707)2.57800240
48Abnormal rod and cone electroretinograms (HP:0008323)2.54476530
49Sclerocornea (HP:0000647)2.53813865
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.49930394
51Abnormal drinking behavior (HP:0030082)2.46618549
52Polydipsia (HP:0001959)2.46618549
53Lissencephaly (HP:0001339)2.45895769
54Nonprogressive disorder (HP:0003680)2.44717863
55Bronchiectasis (HP:0002110)2.44213280
56Decreased circulating renin level (HP:0003351)2.39991999
57Infertility (HP:0000789)2.39600667
58Nephrogenic diabetes insipidus (HP:0009806)2.38644330
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37958051
60Polyuria (HP:0000103)2.35911946
61Anencephaly (HP:0002323)2.35814881
62Unilateral renal agenesis (HP:0000122)2.34718928
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.34147520
64Abnormality of the nasal mucosa (HP:0000433)2.33664166
65Inability to walk (HP:0002540)2.33160025
66Protruding tongue (HP:0010808)2.30188553
67Broad-based gait (HP:0002136)2.29578197
68Severe Myopia (HP:0011003)2.28873994
69Renal cortical cysts (HP:0000803)2.26621605
70Focal motor seizures (HP:0011153)2.25435913
71Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24978838
72Cerebellar dysplasia (HP:0007033)2.24182359
73Congenital hepatic fibrosis (HP:0002612)2.22526662
74Progressive cerebellar ataxia (HP:0002073)2.22469966
75Action tremor (HP:0002345)2.18754400
76Stomatitis (HP:0010280)2.17323858
77Asplenia (HP:0001746)2.15074201
78Nephronophthisis (HP:0000090)2.13550008
79Thyroid-stimulating hormone excess (HP:0002925)2.13103679
80Optic neuritis (HP:0100653)2.13001773
81Retrobulbar optic neuritis (HP:0100654)2.13001773
82Hypoplasia of the pons (HP:0012110)2.12678407
83Bony spicule pigmentary retinopathy (HP:0007737)2.12181055
84Postaxial foot polydactyly (HP:0001830)2.12116343
85Congenital sensorineural hearing impairment (HP:0008527)2.11810010
86Fatigable weakness (HP:0003473)2.10989477
87Abnormality of the neuromuscular junction (HP:0003398)2.10989477
88Abnormality of the pons (HP:0007361)2.09020695
89Furrowed tongue (HP:0000221)2.07938486
90Pachygyria (HP:0001302)2.07920788
91Chorioretinal atrophy (HP:0000533)2.07665162
92Abnormality of the fovea (HP:0000493)2.06340698
93Abnormality of the labia minora (HP:0012880)2.06205046
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04659983
95Hypoplasia of the fovea (HP:0007750)2.03073386
96Aplasia/Hypoplasia of the fovea (HP:0008060)2.03073386
97Vaginal atresia (HP:0000148)2.02989910
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.02487614
99Renal dysplasia (HP:0000110)2.02334536
100Male pseudohermaphroditism (HP:0000037)2.02246240
101Bile duct proliferation (HP:0001408)2.01590074
102Abnormal biliary tract physiology (HP:0012439)2.01590074
103Abnormality of magnesium homeostasis (HP:0004921)2.00539883
104Acute necrotizing encephalopathy (HP:0006965)1.98397392
105Limb dystonia (HP:0002451)1.97741081
106Abnormality of alanine metabolism (HP:0010916)1.97565996
107Hyperalaninemia (HP:0003348)1.97565996
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97565996
109Alveolar cell carcinoma (HP:0006519)1.97139744
110Muscle fiber atrophy (HP:0100295)1.96819967
111Polyphagia (HP:0002591)1.96614768
112Chronic otitis media (HP:0000389)1.95518030
113Poor suck (HP:0002033)1.95260388
114Enlarged kidneys (HP:0000105)1.94811324
115Hypothermia (HP:0002045)1.94268436
116Genital tract atresia (HP:0001827)1.93971825
117Retinal dysplasia (HP:0007973)1.93867340
118Abnormal urine output (HP:0012590)1.92051434
119Gaze-evoked nystagmus (HP:0000640)1.91788508
120Distal lower limb amyotrophy (HP:0008944)1.91130707
121Menstrual irregularities (HP:0000858)1.90318593
122Patellar aplasia (HP:0006443)1.89485282
123Concave nail (HP:0001598)1.89085225
124Recurrent cutaneous fungal infections (HP:0011370)1.88336161
125Chronic mucocutaneous candidiasis (HP:0002728)1.88336161
126Resting tremor (HP:0002322)1.87896457
127Gonadotropin excess (HP:0000837)1.86144667
128Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85895115
129Elfin facies (HP:0004428)1.85381914
130Optic nerve hypoplasia (HP:0000609)1.83470554
131Postaxial hand polydactyly (HP:0001162)1.82059525
132Chronic sinusitis (HP:0011109)1.80864468
133Large for gestational age (HP:0001520)1.79621079
134Aplasia/Hypoplasia of the patella (HP:0006498)1.79457640
135Aplasia/Hypoplasia of the lens (HP:0008063)1.77807087
136Dandy-Walker malformation (HP:0001305)1.77505269
137Optic disc pallor (HP:0000543)1.77332921
138Abnormality of the renal medulla (HP:0100957)1.76471111
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75100117
140Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74668511
141Abnormality of renal excretion (HP:0011036)1.74661417
142Occipital encephalocele (HP:0002085)1.74577505
143Conical tooth (HP:0000698)1.74107996
144Focal seizures (HP:0007359)1.73843841
145Poor coordination (HP:0002370)1.73685637
146Agammaglobulinemia (HP:0004432)1.73650549
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73584001
148Absent epiphyses (HP:0010577)1.73584001
149Acute encephalopathy (HP:0006846)1.73384567
150Genetic anticipation (HP:0003743)1.72297731
151Preaxial hand polydactyly (HP:0001177)1.71936572
152Abnormality of abdominal situs (HP:0011620)1.71866544
153Abdominal situs inversus (HP:0003363)1.71866544
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71519970
155Esotropia (HP:0000565)1.71508213
156Distal lower limb muscle weakness (HP:0009053)1.71105396
157Abnormality of the renal collecting system (HP:0004742)1.70979739
158Recurrent gram-negative bacterial infections (HP:0005420)1.69743723
159Overriding aorta (HP:0002623)1.69525664
160Congenital, generalized hypertrichosis (HP:0004540)1.69441208
161Progressive macrocephaly (HP:0004481)1.69336496
162Progressive inability to walk (HP:0002505)1.68702843
163Clumsiness (HP:0002312)1.68470952
164Disinhibition (HP:0000734)1.68135463
165Double outlet right ventricle (HP:0001719)1.67548952
166Congenital malformation of the right heart (HP:0011723)1.67548952
167Neoplasm of the tracheobronchial system (HP:0100552)1.66560481
168Bronchitis (HP:0012387)1.65964998
169Recurrent fungal infections (HP:0002841)1.65852931
170Orchitis (HP:0100796)1.65820494
171Renovascular hypertension (HP:0100817)1.64403289
172Abnormality of renin-angiotensin system (HP:0000847)1.63228211
173Spastic tetraparesis (HP:0001285)1.62965554
174Weak cry (HP:0001612)1.62363541
175Lower limb amyotrophy (HP:0007210)1.61842731
176Depression (HP:0000716)1.61188671
177Generalized tonic-clonic seizures (HP:0002069)1.60363173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.85511574
2CASK4.72335725
3PDK44.16452146
4PDK34.16452146
5TLK13.70483918
6IRAK33.04099890
7PDK22.96136231
8PRPF4B2.75384835
9EIF2AK22.66732447
10MST42.61489348
11ZAK2.60239590
12NTRK32.55269021
13MAP4K22.49429614
14NTRK22.08784436
15NTRK12.06637736
16TAOK32.06145417
17MAP3K42.03170365
18NUAK11.95630481
19BLK1.88589280
20BMPR1B1.83877009
21GRK71.82545082
22PINK11.81128857
23OBSCN1.75905432
24MAP3K141.70649138
25IRAK11.63518238
26STK391.63116709
27MAP2K71.62498727
28SGK21.57890303
29ACVR1B1.49826333
30DYRK21.49097624
31NME11.41570470
32MKNK21.40743681
33YES11.38201686
34TGFBR21.37978228
35GRK11.32743616
36PKN11.28450551
37MAPK131.28330278
38TNIK1.24987869
39TNK21.22092752
40GRK51.21659869
41ADRBK21.20804219
42IKBKE1.19712376
43SGK2231.13610871
44SGK4941.13610871
45STK161.13376826
46PAK31.11635060
47PRKD31.11015147
48BMPR21.11010625
49CAMKK21.09578916
50SIK21.09434790
51WNK41.08278627
52MUSK1.07037506
53TIE11.06133093
54MST1R1.05463483
55DYRK31.05062873
56INSRR1.04284491
57PAK61.02494818
58SGK31.01507731
59IRAK41.01165037
60CDK191.00832210
61PIK3CA1.00706523
62MAP3K90.99625073
63PRKCG0.97556791
64MOS0.94307729
65PLK20.91043137
66BCKDK0.90024281
67RIPK40.88164233
68WNK30.87444740
69PDK10.87075204
70CAMK1G0.86459988
71FES0.85889031
72TRIM280.85836280
73OXSR10.79678845
74DAPK20.78268271
75WNK10.77666042
76STK40.76816267
77TXK0.74794962
78PLK40.71408119
79CAMK2A0.70603822
80BRAF0.70393320
81STK100.68291986
82PRKCE0.67538820
83TEC0.66282086
84EPHA40.63813512
85SGK10.62992091
86BRSK20.61999930
87PHKG10.61734115
88PHKG20.61734115
89ERBB20.61021654
90TBK10.59103962
91RPS6KB10.58371700
92STK30.56462726
93CAMK40.56267347
94CAMK1D0.55243290
95CSNK1G20.53778343
96MAPKAPK30.53714355
97PRKCQ0.53391311
98SYK0.52838055
99IKBKB0.52754597
100FGR0.52653776
101DDR20.52148573
102CSNK1G30.51858376
103STK110.51850032
104STK38L0.51669596
105CSNK1G10.50438560
106TGFBR10.49732349
107CAMK10.48917477
108MKNK10.48893085
109PLK30.48518571
110KIT0.46909560
111MELK0.46858134
112FGFR20.46628998
113DYRK1A0.46506048
114ADRBK10.45392162
115CLK10.43508294
116RPS6KA50.43458099
117PRKCI0.42701807
118JAK10.42529509
119FER0.41161138
120BCR0.40910114
121MAP2K60.40698188
122LYN0.40474850
123TRPM70.40279442
124PTK2B0.39977138
125PRKCZ0.39940528
126MAP2K40.39197380
127MAPK150.38996285
128VRK10.37911111
129CSNK1A10.37415653
130MAP3K70.37410150
131PRKACA0.37108333
132CAMKK10.35352413
133PIM10.34793459
134MARK10.34777245
135MAP3K50.34579605
136PRKCA0.34426544
137TTK0.34038500
138MAPK120.33919374
139PRKAA20.33417677
140CSNK1D0.33089588
141MAPKAPK50.32721619
142PRKAA10.32461511
143PRKG10.31181440
144TAOK20.31158500
145NLK0.31029761
146RPS6KA60.30863659
147EPHB20.30812491
148CAMK2G0.30528273
149PRKD20.29467086
150MINK10.29155628
151CHEK20.29030766
152AKT30.28997854
153MAP3K130.28309752
154EGFR0.27449289
155FYN0.27159511

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.60479559
2Taste transduction_Homo sapiens_hsa047422.45852915
3Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.20199785
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18959016
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10222627
6Butanoate metabolism_Homo sapiens_hsa006502.10151377
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08955405
8Vitamin B6 metabolism_Homo sapiens_hsa007502.00831112
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.99747970
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91592856
11Histidine metabolism_Homo sapiens_hsa003401.89797511
12Selenocompound metabolism_Homo sapiens_hsa004501.80898319
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74915763
14Nicotine addiction_Homo sapiens_hsa050331.73659224
15Oxidative phosphorylation_Homo sapiens_hsa001901.70349834
16Ovarian steroidogenesis_Homo sapiens_hsa049131.63716812
17Morphine addiction_Homo sapiens_hsa050321.62475001
18Phagosome_Homo sapiens_hsa041451.60943160
19Insulin secretion_Homo sapiens_hsa049111.59846491
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.57265946
21Caffeine metabolism_Homo sapiens_hsa002321.54927251
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54065370
23Olfactory transduction_Homo sapiens_hsa047401.54010145
24Collecting duct acid secretion_Homo sapiens_hsa049661.51474706
25Linoleic acid metabolism_Homo sapiens_hsa005911.49501741
26Fatty acid biosynthesis_Homo sapiens_hsa000611.46726340
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.44668394
28Calcium signaling pathway_Homo sapiens_hsa040201.40344366
29Primary immunodeficiency_Homo sapiens_hsa053401.38327783
30beta-Alanine metabolism_Homo sapiens_hsa004101.38233051
31Synaptic vesicle cycle_Homo sapiens_hsa047211.34983286
32Fat digestion and absorption_Homo sapiens_hsa049751.34817637
33Tryptophan metabolism_Homo sapiens_hsa003801.33801936
34Homologous recombination_Homo sapiens_hsa034401.32825612
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.32535006
36Propanoate metabolism_Homo sapiens_hsa006401.30750315
37Ether lipid metabolism_Homo sapiens_hsa005651.30299041
38Glutamatergic synapse_Homo sapiens_hsa047241.29704726
39Rheumatoid arthritis_Homo sapiens_hsa053231.29636128
40TNF signaling pathway_Homo sapiens_hsa046681.28368358
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26682984
42Circadian entrainment_Homo sapiens_hsa047131.23674436
43Regulation of autophagy_Homo sapiens_hsa041401.23487901
44cAMP signaling pathway_Homo sapiens_hsa040241.23399494
45Sulfur relay system_Homo sapiens_hsa041221.23266841
46Parkinsons disease_Homo sapiens_hsa050121.20640344
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19121085
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17428594
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.16787350
50Dorso-ventral axis formation_Homo sapiens_hsa043201.15991207
51Renin secretion_Homo sapiens_hsa049241.15146130
52One carbon pool by folate_Homo sapiens_hsa006701.15098807
53GABAergic synapse_Homo sapiens_hsa047271.14969763
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14123678
55Arachidonic acid metabolism_Homo sapiens_hsa005901.12439379
56Axon guidance_Homo sapiens_hsa043601.11347802
57RNA polymerase_Homo sapiens_hsa030201.08654430
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.03743911
59Amphetamine addiction_Homo sapiens_hsa050311.02017676
60Cardiac muscle contraction_Homo sapiens_hsa042601.01975470
61Serotonergic synapse_Homo sapiens_hsa047261.00043771
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99966147
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99628651
64Salivary secretion_Homo sapiens_hsa049700.98360569
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98296331
66RNA degradation_Homo sapiens_hsa030180.98296178
67Chemokine signaling pathway_Homo sapiens_hsa040620.98140033
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96954731
69Phenylalanine metabolism_Homo sapiens_hsa003600.92960935
70Peroxisome_Homo sapiens_hsa041460.92719822
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90941189
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90587478
73Protein export_Homo sapiens_hsa030600.90338774
74Hedgehog signaling pathway_Homo sapiens_hsa043400.88694476
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86678452
76Long-term potentiation_Homo sapiens_hsa047200.86149592
77Leishmaniasis_Homo sapiens_hsa051400.85660807
78PPAR signaling pathway_Homo sapiens_hsa033200.84787969
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84771875
80Basal cell carcinoma_Homo sapiens_hsa052170.83901631
81Huntingtons disease_Homo sapiens_hsa050160.82989188
82ABC transporters_Homo sapiens_hsa020100.82586675
83Malaria_Homo sapiens_hsa051440.82553174
84Tuberculosis_Homo sapiens_hsa051520.82454450
85Long-term depression_Homo sapiens_hsa047300.82180595
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80006850
87African trypanosomiasis_Homo sapiens_hsa051430.78566449
88Cholinergic synapse_Homo sapiens_hsa047250.78332623
89Inositol phosphate metabolism_Homo sapiens_hsa005620.78043536
90Vitamin digestion and absorption_Homo sapiens_hsa049770.77870468
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76832978
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76259053
93Ras signaling pathway_Homo sapiens_hsa040140.75329965
94Hematopoietic cell lineage_Homo sapiens_hsa046400.75250259
95Retinol metabolism_Homo sapiens_hsa008300.73268931
96Phototransduction_Homo sapiens_hsa047440.72846065
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72263798
98Alzheimers disease_Homo sapiens_hsa050100.71777025
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.69187052
100Allograft rejection_Homo sapiens_hsa053300.68435270
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68362863
102Pyruvate metabolism_Homo sapiens_hsa006200.68091597
103Chemical carcinogenesis_Homo sapiens_hsa052040.66740847
104B cell receptor signaling pathway_Homo sapiens_hsa046620.66030883
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65624639
106Tyrosine metabolism_Homo sapiens_hsa003500.64436853
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64434684
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62096829
109Graft-versus-host disease_Homo sapiens_hsa053320.61827926
110Type I diabetes mellitus_Homo sapiens_hsa049400.59996899
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59267235
112Steroid biosynthesis_Homo sapiens_hsa001000.58905547
113Glycerolipid metabolism_Homo sapiens_hsa005610.58658631
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56665035
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.56046210
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55622821
117Estrogen signaling pathway_Homo sapiens_hsa049150.55405860
118Measles_Homo sapiens_hsa051620.55366032
119Glucagon signaling pathway_Homo sapiens_hsa049220.54368221
120Purine metabolism_Homo sapiens_hsa002300.54157938
121Metabolic pathways_Homo sapiens_hsa011000.52723941
122Basal transcription factors_Homo sapiens_hsa030220.52509085
123Dopaminergic synapse_Homo sapiens_hsa047280.52330388
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52163095
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51317029
126Fanconi anemia pathway_Homo sapiens_hsa034600.50711246
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.50348769
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49212969
129Osteoclast differentiation_Homo sapiens_hsa043800.49142635
130MAPK signaling pathway_Homo sapiens_hsa040100.48014047
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47682808
132Ribosome_Homo sapiens_hsa030100.47479087
133Oxytocin signaling pathway_Homo sapiens_hsa049210.47313048
134Cocaine addiction_Homo sapiens_hsa050300.46828909
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44695012
136Herpes simplex infection_Homo sapiens_hsa051680.44220484
137Melanogenesis_Homo sapiens_hsa049160.44202590
138T cell receptor signaling pathway_Homo sapiens_hsa046600.44051806
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.43538077
140Fatty acid elongation_Homo sapiens_hsa000620.41221071
141Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40686361
142Gastric acid secretion_Homo sapiens_hsa049710.39742822
143Pancreatic secretion_Homo sapiens_hsa049720.38754855
144Mismatch repair_Homo sapiens_hsa034300.38102557
145Circadian rhythm_Homo sapiens_hsa047100.37359066

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