TMC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that is necesssary for mechanotransduction in cochlear hair cells of the inner ear. Mutations in this gene may underlie hereditary disorders of balance and hearing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)4.74063100
2presynaptic membrane assembly (GO:0097105)4.72596641
3indole-containing compound catabolic process (GO:0042436)4.69006349
4indolalkylamine catabolic process (GO:0046218)4.69006349
5tryptophan catabolic process (GO:0006569)4.69006349
6superoxide anion generation (GO:0042554)4.64997088
7presynaptic membrane organization (GO:0097090)4.52235389
8protein K11-linked deubiquitination (GO:0035871)4.21562016
9cilium or flagellum-dependent cell motility (GO:0001539)4.14613906
10neural tube formation (GO:0001841)4.13838719
11kynurenine metabolic process (GO:0070189)4.06275335
12tryptophan metabolic process (GO:0006568)3.97508103
13detection of light stimulus involved in sensory perception (GO:0050962)3.89076202
14detection of light stimulus involved in visual perception (GO:0050908)3.89076202
15signal peptide processing (GO:0006465)3.84249691
16limb bud formation (GO:0060174)3.67289147
17L-fucose catabolic process (GO:0042355)3.62600788
18fucose catabolic process (GO:0019317)3.62600788
19L-fucose metabolic process (GO:0042354)3.62600788
20indole-containing compound metabolic process (GO:0042430)3.61659733
21photoreceptor cell maintenance (GO:0045494)3.60851792
22negative regulation of mast cell activation (GO:0033004)3.60756568
23negative regulation of myoblast differentiation (GO:0045662)3.59691643
24negative regulation of cytosolic calcium ion concentration (GO:0051481)3.58750147
25serotonin receptor signaling pathway (GO:0007210)3.57259011
26startle response (GO:0001964)3.54963248
27long-chain fatty acid biosynthetic process (GO:0042759)3.54268638
28gamma-aminobutyric acid transport (GO:0015812)3.52151169
29regulation of activation of Janus kinase activity (GO:0010533)3.48564987
30* detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.46831039
31behavioral response to ethanol (GO:0048149)3.46792021
32neuron cell-cell adhesion (GO:0007158)3.40595109
33cellular ketone body metabolic process (GO:0046950)3.38553049
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38521438
35response to pheromone (GO:0019236)3.35841645
36cerebral cortex radially oriented cell migration (GO:0021799)3.35828455
37serotonin metabolic process (GO:0042428)3.32130207
38piRNA metabolic process (GO:0034587)3.31648816
39amine catabolic process (GO:0009310)3.26955556
40cellular biogenic amine catabolic process (GO:0042402)3.26955556
41proline transport (GO:0015824)3.16692208
42primary amino compound metabolic process (GO:1901160)3.15186621
43tachykinin receptor signaling pathway (GO:0007217)3.14486570
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13397003
45neuronal action potential (GO:0019228)3.11914161
46regulation of hippo signaling (GO:0035330)3.10403123
47ketone body metabolic process (GO:1902224)3.08395092
48axoneme assembly (GO:0035082)3.08225109
49retinal cone cell development (GO:0046549)3.05336617
50oligosaccharide catabolic process (GO:0009313)3.04391685
51positive regulation of cellular amide metabolic process (GO:0034250)3.02481204
52auditory receptor cell stereocilium organization (GO:0060088)3.02301548
53positive regulation of oligodendrocyte differentiation (GO:0048714)2.98530417
54positive regulation of protein homodimerization activity (GO:0090073)2.97360398
55cornea development in camera-type eye (GO:0061303)2.96359653
56detection of other organism (GO:0098543)2.95998144
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95339049
58sulfation (GO:0051923)2.95068485
59mesenchymal cell differentiation involved in kidney development (GO:0072161)2.93604866
60mesenchymal cell differentiation involved in renal system development (GO:2001012)2.93604866
61postsynaptic membrane organization (GO:0001941)2.92597372
62epithelial cilium movement (GO:0003351)2.92459198
63regulation of sarcomere organization (GO:0060297)2.90704988
64regulation of gene silencing by RNA (GO:0060966)2.87715264
65regulation of posttranscriptional gene silencing (GO:0060147)2.87715264
66regulation of gene silencing by miRNA (GO:0060964)2.87715264
67inner ear receptor stereocilium organization (GO:0060122)2.87231950
68extracellular negative regulation of signal transduction (GO:1900116)2.86545364
69extracellular regulation of signal transduction (GO:1900115)2.86545364
70cilium morphogenesis (GO:0060271)2.86224656
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82863184
72glycosphingolipid catabolic process (GO:0046479)2.82296202
73cell proliferation in forebrain (GO:0021846)2.82045201
74response to peptidoglycan (GO:0032494)2.81835218
75regulation of cilium movement (GO:0003352)2.79710321
76transmission of nerve impulse (GO:0019226)2.79592699
77regulation of collateral sprouting (GO:0048670)2.79241589
78ceramide catabolic process (GO:0046514)2.78783113
79cellular response to sterol (GO:0036315)2.78665079
80detection of bacterium (GO:0016045)2.78098342
81cilium movement (GO:0003341)2.76212264
82female gonad development (GO:0008585)2.74009162
83thyroid hormone metabolic process (GO:0042403)2.73063934
84benzene-containing compound metabolic process (GO:0042537)2.73022276
85regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.70814709
86positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.70814709
87neuronal action potential propagation (GO:0019227)2.69672160
88nonmotile primary cilium assembly (GO:0035058)2.69032347
89righting reflex (GO:0060013)2.68736887
90microtubule depolymerization (GO:0007019)2.68401327
91* reflex (GO:0060004)2.68058166
92prenylation (GO:0097354)2.67707752
93protein prenylation (GO:0018342)2.67707752
94centriole replication (GO:0007099)2.65828614
95negative regulation of T cell mediated immunity (GO:0002710)2.65232542
96cilium organization (GO:0044782)2.65196403
97photoreceptor cell development (GO:0042461)2.64498201
98monoubiquitinated protein deubiquitination (GO:0035520)2.63706808
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62136197
100negative regulation of translation, ncRNA-mediated (GO:0040033)2.62136197
101regulation of translation, ncRNA-mediated (GO:0045974)2.62136197
102regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.61796766
103cilium assembly (GO:0042384)2.60212466
104positive regulation of action potential (GO:0045760)2.58785600
105negative regulation of keratinocyte proliferation (GO:0010839)2.58515553
106dendritic cell chemotaxis (GO:0002407)2.58099445
107cAMP catabolic process (GO:0006198)2.57997917
108adenine nucleotide transport (GO:0051503)2.57551049
109opioid receptor signaling pathway (GO:0038003)2.57431476
110adaptation of signaling pathway (GO:0023058)2.57127917
111neurotransmitter-gated ion channel clustering (GO:0072578)2.57102366
112energy homeostasis (GO:0097009)2.56928673
113establishment of protein localization to Golgi (GO:0072600)2.56537967
114developmental pigmentation (GO:0048066)2.56255693
115regulation of glucokinase activity (GO:0033131)2.56207851
116regulation of hexokinase activity (GO:1903299)2.56207851
117regulation of timing of cell differentiation (GO:0048505)2.56184846
118regulation of action potential (GO:0098900)2.56086707
119natural killer cell activation involved in immune response (GO:0002323)2.55940752
120protein polyglutamylation (GO:0018095)2.55419153
121DNA double-strand break processing (GO:0000729)2.53893596
122positive regulation of heat generation (GO:0031652)2.53782110
123reciprocal DNA recombination (GO:0035825)2.53052021
124reciprocal meiotic recombination (GO:0007131)2.53052021
125NAD biosynthetic process (GO:0009435)2.52036295
126aromatic amino acid family catabolic process (GO:0009074)2.51738028
127cyclic nucleotide catabolic process (GO:0009214)2.51706299
128central nervous system neuron axonogenesis (GO:0021955)2.51280470
129regulation of rhodopsin mediated signaling pathway (GO:0022400)2.51235966
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49976963
131protein localization to cilium (GO:0061512)2.49152331
132membrane depolarization during action potential (GO:0086010)2.49018390
133protein localization to synapse (GO:0035418)2.48439949
134recombinational repair (GO:0000725)2.48256854
135glycolipid catabolic process (GO:0019377)2.48070049
136protein heterotetramerization (GO:0051290)2.47726460
137behavioral response to nicotine (GO:0035095)2.47536203
138L-methionine salvage (GO:0071267)2.47176713
139L-methionine biosynthetic process (GO:0071265)2.47176713
140amino acid salvage (GO:0043102)2.47176713
141replication fork processing (GO:0031297)2.46662059
142central nervous system myelination (GO:0022010)2.45477017
143axon ensheathment in central nervous system (GO:0032291)2.45477017
144double-strand break repair via homologous recombination (GO:0000724)2.45283581
145positive regulation of developmental pigmentation (GO:0048087)2.45164223
146lipoxygenase pathway (GO:0019372)2.44128276
147positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.44027951
148superoxide metabolic process (GO:0006801)2.42306876
149negative regulation of homotypic cell-cell adhesion (GO:0034111)2.38888548
150amino acid import (GO:0043090)2.38792039
151sympathetic nervous system development (GO:0048485)2.38619668
152negative regulation of protein localization to cell surface (GO:2000009)2.38355067
153positive regulation of uterine smooth muscle contraction (GO:0070474)2.37552386
154forebrain neuron differentiation (GO:0021879)2.37245369
155positive regulation of cell fate commitment (GO:0010455)2.37205688
156olfactory bulb development (GO:0021772)2.35239767
157cellular anion homeostasis (GO:0030002)2.34835233
158nucleoside diphosphate catabolic process (GO:0009134)2.34154317
159regulation of platelet aggregation (GO:0090330)2.32176785
160positive regulation of monocyte chemotaxis (GO:0090026)2.31786609
161dendritic cell migration (GO:0036336)2.30687732
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.30318997
163positive regulation of antigen processing and presentation (GO:0002579)2.30075576
164positive regulation of smooth muscle cell migration (GO:0014911)2.29807390
165glycerophospholipid catabolic process (GO:0046475)2.27899990
166rhodopsin mediated signaling pathway (GO:0016056)2.27871976
167purine ribonucleotide transport (GO:0015868)2.26477181
168kidney morphogenesis (GO:0060993)2.25993799
169neutrophil activation involved in immune response (GO:0002283)2.25389046
170adenosine metabolic process (GO:0046085)2.25385166
171DNA methylation involved in gamete generation (GO:0043046)2.24372293
172L-amino acid import (GO:0043092)2.23938303
173detection of molecule of bacterial origin (GO:0032490)2.23678228
174negative regulation of exocytosis (GO:0045920)2.23333043
175positive regulation of interleukin-17 production (GO:0032740)2.22922695
176positive regulation of synapse assembly (GO:0051965)2.21967420
177regulation of antigen processing and presentation (GO:0002577)2.21427222
178negative regulation of systemic arterial blood pressure (GO:0003085)2.21347772
179nucleotide transmembrane transport (GO:1901679)2.21037136
180regulation of inositol phosphate biosynthetic process (GO:0010919)2.20190843
181G-protein coupled receptor internalization (GO:0002031)2.20067282
182positive regulation of prostaglandin secretion (GO:0032308)2.20060903
183centriole assembly (GO:0098534)2.19831127
184negative regulation of execution phase of apoptosis (GO:1900118)2.19520115
185response to folic acid (GO:0051593)2.18636120
186ganglion development (GO:0061548)2.17943823
187regulation of fever generation (GO:0031620)2.17567519
188positive regulation of meiosis (GO:0045836)2.16177927
189positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.15699034
190monocyte chemotaxis (GO:0002548)2.15337029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.05511944
2ZNF274_21170338_ChIP-Seq_K562_Hela3.18911127
3EZH2_22144423_ChIP-Seq_EOC_Human3.07552835
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00359199
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.89100260
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.87637687
7VDR_22108803_ChIP-Seq_LS180_Human2.58043922
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53731405
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.45418686
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.43960208
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.34559912
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.19695963
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.16286866
14TAF15_26573619_Chip-Seq_HEK293_Human2.12271793
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11904172
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.10243127
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.09516491
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05463695
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.00847630
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00290316
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.99103255
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.97415251
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94532250
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92702408
25P300_19829295_ChIP-Seq_ESCs_Human1.89312169
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85227332
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.81079071
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81057220
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80157669
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.79723437
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.78220692
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76420518
33RNF2_27304074_Chip-Seq_NSC_Mouse1.74541964
34IGF1R_20145208_ChIP-Seq_DFB_Human1.74101345
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.73081690
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71203973
37P53_22387025_ChIP-Seq_ESCs_Mouse1.70262116
38* STAT3_18555785_Chip-Seq_ESCs_Mouse1.69277394
39* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.67645633
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67052977
41BCAT_22108803_ChIP-Seq_LS180_Human1.66669438
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65122494
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65122494
44CBP_20019798_ChIP-Seq_JUKART_Human1.64239460
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64239460
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63200632
47ER_23166858_ChIP-Seq_MCF-7_Human1.62929606
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62036625
49* NMYC_18555785_Chip-Seq_ESCs_Mouse1.61480062
50* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61214839
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59959551
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59563111
53* CMYC_18555785_Chip-Seq_ESCs_Mouse1.59152568
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58368028
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57586957
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57353892
57* P300_18555785_Chip-Seq_ESCs_Mouse1.54698645
58RUNX1_27457419_Chip-Seq_LIVER_Mouse1.53486862
59AR_21572438_ChIP-Seq_LNCaP_Human1.50997691
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.50526865
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.50441594
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50260114
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.50074284
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49543671
65* SOX2_18555785_Chip-Seq_ESCs_Mouse1.48437404
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48255178
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46596552
68* OCT4_18555785_Chip-Seq_ESCs_Mouse1.44988631
69IRF1_19129219_ChIP-ChIP_H3396_Human1.44531320
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42523055
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41341637
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40604574
73* ZFX_18555785_Chip-Seq_ESCs_Mouse1.40104640
74* PU1_27457419_Chip-Seq_LIVER_Mouse1.39670097
75FUS_26573619_Chip-Seq_HEK293_Human1.39489499
76* SMAD4_21799915_ChIP-Seq_A2780_Human1.39243876
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38944758
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38480407
79TCF4_22108803_ChIP-Seq_LS180_Human1.38271244
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38031944
81TP53_18474530_ChIP-ChIP_U2OS_Human1.37750782
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36890269
83TP53_22573176_ChIP-Seq_HFKS_Human1.34937652
84* KLF4_18555785_Chip-Seq_ESCs_Mouse1.34414261
85* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34320782
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33552263
87SOX2_19829295_ChIP-Seq_ESCs_Human1.32932851
88NANOG_19829295_ChIP-Seq_ESCs_Human1.32932851
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32282840
90EWS_26573619_Chip-Seq_HEK293_Human1.32248690
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31995121
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31792967
93REST_21632747_ChIP-Seq_MESCs_Mouse1.31375965
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31042068
95* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30534850
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.29748061
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.28354583
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.28025068
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27860150
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.26765666
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.25972983
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25491560
103* CTCF_18555785_Chip-Seq_ESCs_Mouse1.25338552
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24608988
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.24369496
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23058072
107SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22463655
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22404450
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22360672
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21470992
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21092319
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21092319
113TP53_16413492_ChIP-PET_HCT116_Human1.20563310
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18724511
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18379232
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18330704
117MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17830419
118RUNX2_22187159_ChIP-Seq_PCA_Human1.17524147
119TP63_19390658_ChIP-ChIP_HaCaT_Human1.17381441
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16775119
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16684285
122IRF8_21731497_ChIP-ChIP_J774_Mouse1.15762104
123AR_25329375_ChIP-Seq_VCAP_Human1.15200014
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14704899
125KDM2B_26808549_Chip-Seq_REH_Human1.14528229
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13941310
127STAT3_23295773_ChIP-Seq_U87_Human1.13921122
128TCF4_23295773_ChIP-Seq_U87_Human1.12617005
129FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09694288
130FOXA1_25329375_ChIP-Seq_VCAP_Human1.09694288
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08985015
132* CDX2_22108803_ChIP-Seq_LS180_Human1.08052481
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07330853
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06671458
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05015752
136DROSHA_22980978_ChIP-Seq_HELA_Human1.03927253
137SOX2_21211035_ChIP-Seq_LN229_Gbm1.03046540
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01087326
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01080142
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98448842
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.98044763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.99088780
2MP0006292_abnormal_olfactory_placode3.85498825
3MP0002102_abnormal_ear_morphology3.71879408
4MP0000569_abnormal_digit_pigmentation3.50392222
5MP0003136_yellow_coat_color3.46322911
6MP0001986_abnormal_taste_sensitivity3.09539006
7MP0003880_abnormal_central_pattern3.02960634
8MP0000566_synostosis3.00451105
9MP0003195_calcinosis2.94899809
10MP0002277_abnormal_respiratory_mucosa2.79062504
11MP0005646_abnormal_pituitary_gland2.63690018
12MP0005423_abnormal_somatic_nervous2.62747214
13MP0005171_absent_coat_pigmentation2.51432977
14MP0008877_abnormal_DNA_methylation2.34140222
15MP0002638_abnormal_pupillary_reflex2.24955179
16MP0004381_abnormal_hair_follicle2.20755641
17MP0010386_abnormal_urinary_bladder2.14828490
18MP0002735_abnormal_chemical_nociception2.12417861
19MP0005409_darkened_coat_color2.04761912
20MP0005645_abnormal_hypothalamus_physiol2.03661308
21MP0004742_abnormal_vestibular_system2.00024459
22MP0006276_abnormal_autonomic_nervous1.99497350
23MP0005503_abnormal_tendon_morphology1.93233594
24MP0008260_abnormal_autophagy1.90617192
25MP0002837_dystrophic_cardiac_calcinosis1.84187569
26MP0003646_muscle_fatigue1.76885678
27MP0006072_abnormal_retinal_apoptosis1.74278922
28MP0001486_abnormal_startle_reflex1.72890854
29MP0000015_abnormal_ear_pigmentation1.71396881
30MP0003724_increased_susceptibility_to1.69694343
31MP0001346_abnormal_lacrimal_gland1.69252900
32MP0002163_abnormal_gland_morphology1.68698025
33MP0000427_abnormal_hair_cycle1.67941956
34MP0002938_white_spotting1.65508058
35MP0003941_abnormal_skin_development1.57124172
36MP0009745_abnormal_behavioral_response1.52887851
37MP0008872_abnormal_physiological_respon1.52412464
38MP0002876_abnormal_thyroid_physiology1.50648814
39MP0000778_abnormal_nervous_system1.50413210
40MP0000372_irregular_coat_pigmentation1.49641693
41MP0009379_abnormal_foot_pigmentation1.46819098
42MP0005451_abnormal_body_composition1.45563246
43MP0004043_abnormal_pH_regulation1.44447472
44MP0002148_abnormal_hypersensitivity_rea1.39605624
45MP0001905_abnormal_dopamine_level1.39573721
46MP0001502_abnormal_circadian_rhythm1.39258840
47MP0002736_abnormal_nociception_after1.38301832
48MP0005386_behavior/neurological_phenoty1.37603578
49MP0004924_abnormal_behavior1.37603578
50MP0001968_abnormal_touch/_nociception1.36070304
51MP0001529_abnormal_vocalization1.35455926
52MP0001984_abnormal_olfaction1.30928271
53MP0002572_abnormal_emotion/affect_behav1.30279985
54MP0004133_heterotaxia1.29695672
55MP0000026_abnormal_inner_ear1.29280759
56MP0002138_abnormal_hepatobiliary_system1.28036733
57MP0004145_abnormal_muscle_electrophysio1.27504450
58MP0008875_abnormal_xenobiotic_pharmacok1.27384038
59MP0005257_abnormal_intraocular_pressure1.26934798
60MP0002653_abnormal_ependyma_morphology1.26030426
61MP0009697_abnormal_copulation1.25293661
62MP0002234_abnormal_pharynx_morphology1.22562744
63MP0003011_delayed_dark_adaptation1.21620226
64MP0002928_abnormal_bile_duct1.21561768
65MP0005379_endocrine/exocrine_gland_phen1.20412721
66MP0008057_abnormal_DNA_replication1.18894347
67MP0000383_abnormal_hair_follicle1.18421052
68MP0002249_abnormal_larynx_morphology1.17740544
69MP0002557_abnormal_social/conspecific_i1.16933262
70MP0001835_abnormal_antigen_presentation1.15799050
71MP0004782_abnormal_surfactant_physiolog1.15411891
72MP0003938_abnormal_ear_development1.14924766
73MP0009046_muscle_twitch1.14396718
74MP0002067_abnormal_sensory_capabilities1.14311020
75MP0002064_seizures1.13941332
76MP0002734_abnormal_mechanical_nocicepti1.13094304
77MP0008058_abnormal_DNA_repair1.12767645
78MP0004885_abnormal_endolymph1.12437697
79MP0008995_early_reproductive_senescence1.10467173
80MP0002272_abnormal_nervous_system1.09778159
81MP0004215_abnormal_myocardial_fiber1.08432960
82MP0005085_abnormal_gallbladder_physiolo1.08388438
83MP0005551_abnormal_eye_electrophysiolog1.05870878
84MP0003718_maternal_effect1.04301985
85MP0005167_abnormal_blood-brain_barrier1.04297171
86MP0001963_abnormal_hearing_physiology1.03981669
87MP0003890_abnormal_embryonic-extraembry1.03944427
88MP0002063_abnormal_learning/memory/cond1.02882065
89MP0005174_abnormal_tail_pigmentation1.00849770
90MP0003950_abnormal_plasma_membrane0.99365312
91MP0000230_abnormal_systemic_arterial0.98519252
92MP0005670_abnormal_white_adipose0.98019254
93MP0005187_abnormal_penis_morphology0.97959726
94MP0001790_abnormal_immune_system0.97800598
95MP0005387_immune_system_phenotype0.97800598
96MP0005410_abnormal_fertilization0.97768068
97MP0005195_abnormal_posterior_eye0.97272365
98MP0003635_abnormal_synaptic_transmissio0.96042791
99MP0009785_altered_susceptibility_to0.95715264
100MP0009764_decreased_sensitivity_to0.94949276
101MP0002229_neurodegeneration0.91059924
102MP0003878_abnormal_ear_physiology0.90702936
103MP0005377_hearing/vestibular/ear_phenot0.90702936
104MP0003698_abnormal_male_reproductive0.90685424
105MP0002184_abnormal_innervation0.89135735
106MP0003787_abnormal_imprinting0.87699429
107MP0001324_abnormal_eye_pigmentation0.86645373
108MP0003252_abnormal_bile_duct0.86308983
109MP0005253_abnormal_eye_physiology0.85527524
110MP0005389_reproductive_system_phenotype0.85271373
111MP0003633_abnormal_nervous_system0.84221421
112MP0005075_abnormal_melanosome_morpholog0.83228975
113MP0001970_abnormal_pain_threshold0.83175538
114MP0004134_abnormal_chest_morphology0.81599277
115MP0005310_abnormal_salivary_gland0.81373674
116MP0004142_abnormal_muscle_tone0.79833978
117MP0000681_abnormal_thyroid_gland0.79596901
118MP0002752_abnormal_somatic_nervous0.78875267
119MP0002132_abnormal_respiratory_system0.78671808
120MP0002160_abnormal_reproductive_system0.78400091
121MP0008789_abnormal_olfactory_epithelium0.78221788
122MP0000538_abnormal_urinary_bladder0.77869544
123MP0000049_abnormal_middle_ear0.76795562
124MP0003119_abnormal_digestive_system0.76385545
125MP0001764_abnormal_homeostasis0.75761245
126MP0001929_abnormal_gametogenesis0.75533508
127MP0002419_abnormal_innate_immunity0.74592061
128MP0000631_abnormal_neuroendocrine_gland0.74422716
129MP0000613_abnormal_salivary_gland0.71596316
130MP0002095_abnormal_skin_pigmentation0.70180928
131MP0002733_abnormal_thermal_nociception0.69219617
132MP0003937_abnormal_limbs/digits/tail_de0.68346373
133MP0005000_abnormal_immune_tolerance0.68191259
134MP0005671_abnormal_response_to0.67386884
135MP0001485_abnormal_pinna_reflex0.67213222
136MP0005084_abnormal_gallbladder_morpholo0.67148054
137MP0002998_abnormal_bone_remodeling0.66998334
138MP0001177_atelectasis0.66623339
139MP0001501_abnormal_sleep_pattern0.66305722
140MP0005248_abnormal_Harderian_gland0.65658626
141MP0004147_increased_porphyrin_level0.65410279
142MP0009250_abnormal_appendicular_skeleto0.65254519
143MP0004859_abnormal_synaptic_plasticity0.64302405
144MP0003315_abnormal_perineum_morphology0.62169893
145MP0002882_abnormal_neuron_morphology0.61156625

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.62241553
2Chromsome breakage (HP:0040012)4.80859074
3Pancreatic cysts (HP:0001737)4.51044189
4Duplicated collecting system (HP:0000081)3.86106565
5Attenuation of retinal blood vessels (HP:0007843)3.84320933
6Molar tooth sign on MRI (HP:0002419)3.72604012
7Abnormality of midbrain morphology (HP:0002418)3.72604012
8Abnormality of the renal collecting system (HP:0004742)3.48557308
9Gaze-evoked nystagmus (HP:0000640)3.37945657
10Abnormality of incisor morphology (HP:0011063)3.28776346
11Retrobulbar optic neuritis (HP:0100654)3.19415280
12Optic neuritis (HP:0100653)3.19415280
13Aplasia cutis congenita (HP:0001057)3.19107246
14Prostate neoplasm (HP:0100787)3.15224983
15Abnormality of the renal cortex (HP:0011035)3.15124158
16Duplication of thumb phalanx (HP:0009942)3.13723392
17Septo-optic dysplasia (HP:0100842)3.10016346
18Type II lissencephaly (HP:0007260)2.94233030
19Cystic liver disease (HP:0006706)2.92990505
20Abolished electroretinogram (ERG) (HP:0000550)2.87936777
21Febrile seizures (HP:0002373)2.86408680
22Conical tooth (HP:0000698)2.86125923
23Progressive cerebellar ataxia (HP:0002073)2.80555845
24Submucous cleft hard palate (HP:0000176)2.78462612
25Congenital stationary night blindness (HP:0007642)2.76472441
26Genetic anticipation (HP:0003743)2.76029528
27Chronic hepatic failure (HP:0100626)2.75094352
28Bony spicule pigmentary retinopathy (HP:0007737)2.74052207
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.69082634
30Protruding tongue (HP:0010808)2.65265982
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.63489548
32Abnormal hair whorl (HP:0010721)2.62842635
33Meckel diverticulum (HP:0002245)2.59320388
34Large for gestational age (HP:0001520)2.55807779
35Abnormality of the preputium (HP:0100587)2.54907183
36Optic nerve hypoplasia (HP:0000609)2.50915130
37Hypothermia (HP:0002045)2.50785444
38Increased corneal curvature (HP:0100692)2.49846898
39Keratoconus (HP:0000563)2.49846898
40Cerebellar dysplasia (HP:0007033)2.48774862
41Focal seizures (HP:0007359)2.48491379
42Abnormal rod and cone electroretinograms (HP:0008323)2.46308012
43Abnormality of the ileum (HP:0001549)2.46173254
44Medial flaring of the eyebrow (HP:0010747)2.42299418
45Ectopic kidney (HP:0000086)2.41938828
46Inability to walk (HP:0002540)2.41876838
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.41718149
48Absent/shortened dynein arms (HP:0200106)2.41718149
49Renal cortical cysts (HP:0000803)2.39428649
50Clubbing of toes (HP:0100760)2.37881727
51Abnormality of macular pigmentation (HP:0008002)2.35495353
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.34915126
53Sclerocornea (HP:0000647)2.34172306
54Dialeptic seizures (HP:0011146)2.32986473
55Genital tract atresia (HP:0001827)2.32267758
56Tubular atrophy (HP:0000092)2.31996118
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29863873
58Abnormality of molar (HP:0011077)2.29677443
59Abnormality of molar morphology (HP:0011070)2.29677443
60Intestinal atresia (HP:0011100)2.29589226
61Absent speech (HP:0001344)2.29405151
62Volvulus (HP:0002580)2.28966595
63Polydipsia (HP:0001959)2.28905180
64Abnormal drinking behavior (HP:0030082)2.28905180
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28122811
66Abnormality of alanine metabolism (HP:0010916)2.28122811
67Hyperalaninemia (HP:0003348)2.28122811
68Broad-based gait (HP:0002136)2.25487195
69Abnormality of DNA repair (HP:0003254)2.24873116
70Fetal akinesia sequence (HP:0001989)2.24610287
71Orchitis (HP:0100796)2.24131284
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23972888
73Abnormal ciliary motility (HP:0012262)2.23948911
74Constricted visual fields (HP:0001133)2.22833642
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22264157
76Male pseudohermaphroditism (HP:0000037)2.21945989
77Furrowed tongue (HP:0000221)2.20325352
78Abnormality of the dental pulp (HP:0006479)2.18725942
79Vaginal atresia (HP:0000148)2.18366335
80Congenital, generalized hypertrichosis (HP:0004540)2.16567103
81Congenital hepatic fibrosis (HP:0002612)2.16333556
82Chronic obstructive pulmonary disease (HP:0006510)2.16062634
83Obstructive lung disease (HP:0006536)2.16062634
84Nephronophthisis (HP:0000090)2.15905185
85True hermaphroditism (HP:0010459)2.15840736
86Patchy hypopigmentation of hair (HP:0011365)2.14288788
87Atonic seizures (HP:0010819)2.14266244
88Progressive inability to walk (HP:0002505)2.12934028
89White forelock (HP:0002211)2.12659545
90Hyperventilation (HP:0002883)2.12307010
91Parakeratosis (HP:0001036)2.11829151
92Decreased circulating renin level (HP:0003351)2.11051191
93Anencephaly (HP:0002323)2.09668615
94Decreased central vision (HP:0007663)2.09260737
95Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08945270
96Lissencephaly (HP:0001339)2.07036700
97Hemiparesis (HP:0001269)2.06739267
98Palpebral edema (HP:0100540)2.04741062
99Abnormality of the labia minora (HP:0012880)2.04075957
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03186046
101Tubulointerstitial nephritis (HP:0001970)2.03092354
102Stomach cancer (HP:0012126)2.02351407
103Small hand (HP:0200055)2.02310024
104Abnormality of the dental root (HP:0006486)2.00030807
105Taurodontia (HP:0000679)2.00030807
106Abnormality of permanent molar morphology (HP:0011071)2.00030807
107Hypergonadotropic hypogonadism (HP:0000815)1.98489768
108Partial duplication of thumb phalanx (HP:0009944)1.98261362
109Nasolacrimal duct obstruction (HP:0000579)1.98159675
110Fair hair (HP:0002286)1.97882330
111Retinal dysplasia (HP:0007973)1.97571531
112Absent septum pellucidum (HP:0001331)1.97227164
113Abnormality of the incisor (HP:0000676)1.96653759
114Abnormality of the columella (HP:0009929)1.96448131
115Abnormality of chromosome stability (HP:0003220)1.96154382
116Absence seizures (HP:0002121)1.96033799
117Hypoplasia of the fovea (HP:0007750)1.95781955
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.95781955
119Widely spaced teeth (HP:0000687)1.95018829
120Xerostomia (HP:0000217)1.94885166
121Postaxial foot polydactyly (HP:0001830)1.93565807
122Type 2 muscle fiber atrophy (HP:0003554)1.91221921
123Increased IgM level (HP:0003496)1.89795266
124Pancreatic fibrosis (HP:0100732)1.89642324
125Retinitis pigmentosa (HP:0000510)1.88790301
126Methylmalonic acidemia (HP:0002912)1.88073621
127Abnormality of the septum pellucidum (HP:0007375)1.86520607
128Type I transferrin isoform profile (HP:0003642)1.86187708
129Poor coordination (HP:0002370)1.85601388
130Abnormality of the nasal septum (HP:0000419)1.85586405
131Astigmatism (HP:0000483)1.85543239
132Adrenal hypoplasia (HP:0000835)1.85286878
133Abnormal biliary tract physiology (HP:0012439)1.85265427
134Bile duct proliferation (HP:0001408)1.85265427
135Nephrogenic diabetes insipidus (HP:0009806)1.85153389
136Polyuria (HP:0000103)1.84801296
137Anomalous pulmonary venous return (HP:0010772)1.84323906
138Congenital sensorineural hearing impairment (HP:0008527)1.84017694
139Thyroid-stimulating hormone excess (HP:0002925)1.82745501
140Abnormality of the renal medulla (HP:0100957)1.82578061
141Abnormal respiratory epithelium morphology (HP:0012253)1.81928988
142Abnormal respiratory motile cilium morphology (HP:0005938)1.81928988
143Focal motor seizures (HP:0011153)1.81852818
144Gait imbalance (HP:0002141)1.81478197
145Nonprogressive disorder (HP:0003680)1.80822228
146Abnormality of the pons (HP:0007361)1.80359672
147Preaxial hand polydactyly (HP:0001177)1.79636424
148Recurrent pneumonia (HP:0006532)1.77673675
149Central scotoma (HP:0000603)1.77607351
150Epileptic encephalopathy (HP:0200134)1.77270886
151Generalized hypopigmentation of hair (HP:0011358)1.76623591
152Abnormality of the prostate (HP:0008775)1.75696177
153Absent radius (HP:0003974)1.75038166
154Congenital primary aphakia (HP:0007707)1.74000783
155Postaxial hand polydactyly (HP:0001162)1.72833468
156Hyperglycinuria (HP:0003108)1.72681009
1573-Methylglutaconic aciduria (HP:0003535)1.72140463
158Hypoplasia of the pons (HP:0012110)1.71701151
159Triphalangeal thumb (HP:0001199)1.70780958
160Keratoconjunctivitis sicca (HP:0001097)1.70346665
161Hypoproteinemia (HP:0003075)1.70247915
162Prominent supraorbital ridges (HP:0000336)1.70132186
163Methylmalonic aciduria (HP:0012120)1.70063095
164Aplasia involving forearm bones (HP:0009822)1.68947614
165Absent forearm bone (HP:0003953)1.68947614
166Abnormality of the pulmonary veins (HP:0011718)1.68581696
167Abnormality of the fovea (HP:0000493)1.67516837
168Joint hemorrhage (HP:0005261)1.65367490
169Abnormal respiratory motile cilium physiology (HP:0012261)1.64895340
170Pendular nystagmus (HP:0012043)1.63749105
171Osteomalacia (HP:0002749)1.62597887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.04094578
2CASK5.17349567
3IRAK33.23189022
4PRPF4B2.91391154
5MKNK22.77877176
6TNIK2.77260701
7MAP3K142.73998925
8MAP4K22.61297427
9MAP2K72.30357199
10YES12.30083570
11ZAK2.21134658
12ACVR1B2.15973915
13IRAK42.06476225
14INSRR1.89209528
15IRAK11.87345757
16BMPR1B1.81857275
17TNK21.80820662
18MARK11.78085809
19TXK1.75257435
20IRAK21.66983281
21SGK21.63267824
22SIK31.61470090
23ADRBK21.59102040
24EIF2AK21.51561941
25NTRK31.48219065
26AKT31.46300167
27NEK61.43836975
28MKNK11.43768147
29BMPR21.43297121
30TAOK31.42225139
31TIE11.40940880
32SGK4941.40273942
33SGK2231.40273942
34PNCK1.37791029
35STK161.37215432
36DAPK21.26378851
37SRPK11.26366095
38DYRK21.25988314
39MAP3K121.23383873
40NLK1.21302673
41CAMKK21.20620739
42MAPK131.17349677
43WNK41.16491294
44PKN11.15178971
45GRK11.14417256
46CDK31.14153883
47PAK31.12420077
48EIF2AK31.10793754
49PIK3CG1.05661588
50TRIM281.05102443
51PRKCE1.00318218
52CCNB11.00239035
53PLK41.00203523
54EPHA31.00176738
55TGFBR10.99935591
56EPHA40.99310806
57BLK0.99025970
58KIT0.98050986
59NTRK20.96163669
60GRK70.95887938
61CDK80.95454190
62CLK10.95246489
63PINK10.94253071
64BCR0.94174030
65OXSR10.90446059
66NUAK10.89150697
67MUSK0.86903243
68PLK20.83920439
69FGFR20.83142928
70ERBB30.79605398
71FER0.78450329
72TRPM70.76857879
73PTK2B0.70931617
74SGK30.70777225
75MAPK150.70120962
76LATS10.67707234
77WEE10.67389084
78STK38L0.66795591
79STK30.65375384
80BRSK20.64560616
81UHMK10.63458569
82MAP3K40.61507497
83TEC0.61025246
84DYRK1A0.60130000
85IKBKB0.58415931
86ERBB40.58192707
87BCKDK0.56890848
88PRKCG0.54331201
89MAPK70.54281908
90ADRBK10.53725566
91CHUK0.53597247
92OBSCN0.53583222
93SGK10.53151831
94PIK3CA0.52448969
95CAMK2A0.51979421
96RIPK40.50954616
97TLK10.47995593
98FES0.46784921
99STK240.46503427
100MAPKAPK30.45931345
101CAMK10.45815863
102FLT30.45522427
103MST40.44433811
104RPS6KB10.43588600
105PHKG20.41488303
106PHKG10.41488303
107NME10.40500964
108PBK0.40279545
109MAPKAPK50.40186328
110NEK20.38694437
111VRK10.38578446
112SIK20.37976926
113BUB10.35924959
114NEK10.35801461
115GRK50.35562793
116LYN0.35532187
117CSNK1G20.34700776
118EPHB20.34304854
119BRAF0.34272271
120RPS6KA50.34049578
121PRKACB0.33679424
122CSNK1D0.33279648
123CSNK1A10.32171419
124IKBKE0.31773616
125ROCK20.31686591
126CDK190.31642232
127PRKAA20.30837049
128CSNK1G10.30755778
129STK390.29937086
130CAMK2B0.29845915
131PRKG10.29806148
132ERBB20.29737740
133PRKCA0.28994652
134PLK30.28428504
135PRKCZ0.28183879
136PRKCQ0.26424179
137CAMK2D0.25868007
138PRKACA0.25636797
139PRKCD0.25560572
140BRD40.24112520
141SYK0.23870533
142PRKD20.22778643
143CAMK40.22371089
144WNK30.21156268
145EIF2AK10.20693645

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.05579894
2Butanoate metabolism_Homo sapiens_hsa006502.78206796
3Phototransduction_Homo sapiens_hsa047442.75560553
4Autoimmune thyroid disease_Homo sapiens_hsa053202.64116610
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.46574948
6Tryptophan metabolism_Homo sapiens_hsa003802.44610634
7Nitrogen metabolism_Homo sapiens_hsa009102.36792806
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.26015475
9Nicotine addiction_Homo sapiens_hsa050332.24824115
10Fanconi anemia pathway_Homo sapiens_hsa034602.20221225
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.06539601
12Rheumatoid arthritis_Homo sapiens_hsa053231.94805789
13Allograft rejection_Homo sapiens_hsa053301.94500048
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85003909
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82782221
16Taste transduction_Homo sapiens_hsa047421.80182757
17ABC transporters_Homo sapiens_hsa020101.78868930
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.77903748
19Sphingolipid metabolism_Homo sapiens_hsa006001.75744820
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.73175211
21Selenocompound metabolism_Homo sapiens_hsa004501.71559086
22Serotonergic synapse_Homo sapiens_hsa047261.69479587
23Propanoate metabolism_Homo sapiens_hsa006401.69354341
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67274792
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66677416
26Arachidonic acid metabolism_Homo sapiens_hsa005901.56707677
27Morphine addiction_Homo sapiens_hsa050321.54475941
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51140445
29Vitamin B6 metabolism_Homo sapiens_hsa007501.50282047
30Type I diabetes mellitus_Homo sapiens_hsa049401.48563248
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.47313097
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46001986
33Collecting duct acid secretion_Homo sapiens_hsa049661.45597685
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40985760
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38508977
36Caffeine metabolism_Homo sapiens_hsa002321.37606463
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32884974
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31936796
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30324944
40Asthma_Homo sapiens_hsa053101.27630810
41Ether lipid metabolism_Homo sapiens_hsa005651.27146295
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25521518
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17711517
44Salivary secretion_Homo sapiens_hsa049701.17400771
45Other glycan degradation_Homo sapiens_hsa005111.16318632
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16038310
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12103693
48Protein export_Homo sapiens_hsa030601.11544534
49Phagosome_Homo sapiens_hsa041451.10474510
50Chemical carcinogenesis_Homo sapiens_hsa052041.10219441
51Non-homologous end-joining_Homo sapiens_hsa034501.09428345
52Measles_Homo sapiens_hsa051621.08251500
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07594791
54Hematopoietic cell lineage_Homo sapiens_hsa046401.06294162
55Glutamatergic synapse_Homo sapiens_hsa047241.04448875
56Insulin secretion_Homo sapiens_hsa049111.02123748
57Glycerolipid metabolism_Homo sapiens_hsa005610.99087566
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98895455
59Steroid biosynthesis_Homo sapiens_hsa001000.98772455
60Olfactory transduction_Homo sapiens_hsa047400.98078029
61Axon guidance_Homo sapiens_hsa043600.96623458
62African trypanosomiasis_Homo sapiens_hsa051430.95342708
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95267455
64Ovarian steroidogenesis_Homo sapiens_hsa049130.94214057
65Regulation of autophagy_Homo sapiens_hsa041400.93531539
66Vitamin digestion and absorption_Homo sapiens_hsa049770.93130113
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92283606
68Dorso-ventral axis formation_Homo sapiens_hsa043200.90555337
69GABAergic synapse_Homo sapiens_hsa047270.88980114
70RNA degradation_Homo sapiens_hsa030180.86953976
71Peroxisome_Homo sapiens_hsa041460.82561852
72Basal transcription factors_Homo sapiens_hsa030220.80926852
73Fatty acid degradation_Homo sapiens_hsa000710.80304508
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80304066
75Parkinsons disease_Homo sapiens_hsa050120.79616697
76Leishmaniasis_Homo sapiens_hsa051400.78532948
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78443141
78Circadian entrainment_Homo sapiens_hsa047130.76498095
79Calcium signaling pathway_Homo sapiens_hsa040200.74287171
80TNF signaling pathway_Homo sapiens_hsa046680.74263977
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74099767
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.73944814
83Chemokine signaling pathway_Homo sapiens_hsa040620.73923898
84Huntingtons disease_Homo sapiens_hsa050160.71018166
85Linoleic acid metabolism_Homo sapiens_hsa005910.70649484
86Oxidative phosphorylation_Homo sapiens_hsa001900.67858790
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.66381162
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65834769
89Malaria_Homo sapiens_hsa051440.64927860
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64734442
91Tuberculosis_Homo sapiens_hsa051520.64623160
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64164817
93Synaptic vesicle cycle_Homo sapiens_hsa047210.63588060
94Dopaminergic synapse_Homo sapiens_hsa047280.62577314
95Long-term depression_Homo sapiens_hsa047300.62006330
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61227622
97Basal cell carcinoma_Homo sapiens_hsa052170.60682748
98Ras signaling pathway_Homo sapiens_hsa040140.57779683
99Herpes simplex infection_Homo sapiens_hsa051680.57625398
100Pertussis_Homo sapiens_hsa051330.56054713
101cAMP signaling pathway_Homo sapiens_hsa040240.55379016
102Salmonella infection_Homo sapiens_hsa051320.55049208
103Fat digestion and absorption_Homo sapiens_hsa049750.54952833
104Circadian rhythm_Homo sapiens_hsa047100.53705590
105Amphetamine addiction_Homo sapiens_hsa050310.52589720
106Mineral absorption_Homo sapiens_hsa049780.52125367
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.51528159
108Cholinergic synapse_Homo sapiens_hsa047250.51362693
109Cardiac muscle contraction_Homo sapiens_hsa042600.51039504
110Metabolic pathways_Homo sapiens_hsa011000.50670988
111Melanoma_Homo sapiens_hsa052180.50425859
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.50346250
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.49819426
114Influenza A_Homo sapiens_hsa051640.49761025
115Homologous recombination_Homo sapiens_hsa034400.49662672
116Oxytocin signaling pathway_Homo sapiens_hsa049210.49383862
117Fatty acid biosynthesis_Homo sapiens_hsa000610.49372539
118beta-Alanine metabolism_Homo sapiens_hsa004100.49290651
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48491523
120Wnt signaling pathway_Homo sapiens_hsa043100.48302239
121Osteoclast differentiation_Homo sapiens_hsa043800.48272973
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48007886
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47861363
124Hedgehog signaling pathway_Homo sapiens_hsa043400.46814351
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46606649
126Purine metabolism_Homo sapiens_hsa002300.46221555
127Cocaine addiction_Homo sapiens_hsa050300.45812227
128Primary immunodeficiency_Homo sapiens_hsa053400.45658909
129Gastric acid secretion_Homo sapiens_hsa049710.45230457
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45213716
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44579179
132Renin secretion_Homo sapiens_hsa049240.44455786
133Alzheimers disease_Homo sapiens_hsa050100.44100709
134Lysine degradation_Homo sapiens_hsa003100.43301275
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43256311
136Fatty acid metabolism_Homo sapiens_hsa012120.42102031
137Staphylococcus aureus infection_Homo sapiens_hsa051500.41794206
138RNA polymerase_Homo sapiens_hsa030200.41198917
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41196297
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41090442
141Retinol metabolism_Homo sapiens_hsa008300.40843991
142MAPK signaling pathway_Homo sapiens_hsa040100.39652002
143Hepatitis C_Homo sapiens_hsa051600.38910392
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37854463
145Histidine metabolism_Homo sapiens_hsa003400.37580142
146ErbB signaling pathway_Homo sapiens_hsa040120.37267938
147One carbon pool by folate_Homo sapiens_hsa006700.36695173
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34636061
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34307330
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33963512
151Pancreatic secretion_Homo sapiens_hsa049720.26110540
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.24163663

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