TMC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)8.23216292
2sympathetic nervous system development (GO:0048485)6.01353985
3neurotransmitter catabolic process (GO:0042135)5.49215784
4behavioral response to nicotine (GO:0035095)5.13356910
5cilium or flagellum-dependent cell motility (GO:0001539)4.71452527
6behavioral response to ethanol (GO:0048149)4.53828995
7cell migration in hindbrain (GO:0021535)4.51237646
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.50359567
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.48556432
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34229776
11thrombin receptor signaling pathway (GO:0070493)4.21734201
12multicellular organism reproduction (GO:0032504)4.08280440
13piRNA metabolic process (GO:0034587)3.99760470
14indolalkylamine metabolic process (GO:0006586)3.93151546
15indolalkylamine catabolic process (GO:0046218)3.92612514
16tryptophan catabolic process (GO:0006569)3.92612514
17indole-containing compound catabolic process (GO:0042436)3.92612514
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.82803821
19dopamine metabolic process (GO:0042417)3.81601789
20retinal cone cell development (GO:0046549)3.76589840
21cellular biogenic amine catabolic process (GO:0042402)3.75625323
22amine catabolic process (GO:0009310)3.75625323
23proline transport (GO:0015824)3.70139874
24protein neddylation (GO:0045116)3.67754364
25vocalization behavior (GO:0071625)3.65817752
26ganglion development (GO:0061548)3.59528393
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.56147853
28glycine transport (GO:0015816)3.55377232
29synaptic vesicle exocytosis (GO:0016079)3.54208518
30cellular response to nicotine (GO:0071316)3.53995143
31tryptophan metabolic process (GO:0006568)3.52490954
32regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.51828339
33regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.51828339
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51633723
35neurotransmitter secretion (GO:0007269)3.49569908
36detection of light stimulus involved in visual perception (GO:0050908)3.48390006
37detection of light stimulus involved in sensory perception (GO:0050962)3.48390006
38response to amphetamine (GO:0001975)3.47341147
39dopamine transport (GO:0015872)3.46927275
40photoreceptor cell maintenance (GO:0045494)3.46803530
41auditory behavior (GO:0031223)3.46186230
42cilium movement (GO:0003341)3.43191631
43regulation of respiratory gaseous exchange (GO:0043576)3.42590827
44positive regulation of neurotransmitter transport (GO:0051590)3.40350348
45maternal behavior (GO:0042711)3.40036315
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36159433
47synaptic transmission, cholinergic (GO:0007271)3.34611599
48purinergic nucleotide receptor signaling pathway (GO:0035590)3.32323392
49epithelial cilium movement (GO:0003351)3.31575007
50catecholamine biosynthetic process (GO:0042423)3.31244394
51catechol-containing compound biosynthetic process (GO:0009713)3.31244394
52signal peptide processing (GO:0006465)3.27566618
53male meiosis (GO:0007140)3.26733366
54neuronal action potential propagation (GO:0019227)3.26479322
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.23412860
56catecholamine transport (GO:0051937)3.23375670
57cerebellar Purkinje cell differentiation (GO:0021702)3.21552021
58regulation of synaptic vesicle exocytosis (GO:2000300)3.19649337
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17962139
60locomotory exploration behavior (GO:0035641)3.17234694
61regulation of acrosome reaction (GO:0060046)3.16252888
62protein localization to synapse (GO:0035418)3.15568931
63L-fucose catabolic process (GO:0042355)3.14869074
64fucose catabolic process (GO:0019317)3.14869074
65L-fucose metabolic process (GO:0042354)3.14869074
66regulation of vesicle fusion (GO:0031338)3.14495801
67DNA double-strand break processing (GO:0000729)3.13595265
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13527355
69positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12849164
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12069204
71negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11716060
72aromatic amino acid family catabolic process (GO:0009074)3.10577210
73regulation of neurotransmitter transport (GO:0051588)3.10187332
74xenobiotic catabolic process (GO:0042178)3.10186982
75ketone body metabolic process (GO:1902224)3.09389178
76regulation of meiosis I (GO:0060631)3.08961870
77high-density lipoprotein particle remodeling (GO:0034375)3.06999113
78positive regulation of vesicle fusion (GO:0031340)3.06801239
79neuromuscular synaptic transmission (GO:0007274)3.06186493
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06124089
81synaptic transmission, dopaminergic (GO:0001963)3.05310824
82norepinephrine metabolic process (GO:0042415)3.05226633
83detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.05201774
84response to water (GO:0009415)3.04176060
85regulation of neurotransmitter uptake (GO:0051580)3.03876531
86regulation of neurotransmitter secretion (GO:0046928)3.03610076
87cellular response to nerve growth factor stimulus (GO:1990090)3.02744624
88response to nerve growth factor (GO:1990089)3.02744624
89cellular ketone body metabolic process (GO:0046950)3.01388990
90sperm motility (GO:0030317)3.01052216
91mating behavior (GO:0007617)3.00790258
92reciprocal DNA recombination (GO:0035825)3.00621113
93reciprocal meiotic recombination (GO:0007131)3.00621113
94glutamate secretion (GO:0014047)2.99691409
95amino acid salvage (GO:0043102)2.98758454
96L-methionine salvage (GO:0071267)2.98758454
97L-methionine biosynthetic process (GO:0071265)2.98758454
98response to auditory stimulus (GO:0010996)2.98744514
99DNA methylation involved in gamete generation (GO:0043046)2.98500894
100reverse cholesterol transport (GO:0043691)2.98127789
101regulation of memory T cell differentiation (GO:0043380)2.94978015
102neurotransmitter transport (GO:0006836)2.94708373
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.93012215
104nerve growth factor signaling pathway (GO:0038180)2.91589477
105axoneme assembly (GO:0035082)2.91400784
106neuron-neuron synaptic transmission (GO:0007270)2.90709311
107regulation of respiratory system process (GO:0044065)2.89765120
108platelet dense granule organization (GO:0060155)2.89762347
109aggressive behavior (GO:0002118)2.89219555
110NAD biosynthetic process (GO:0009435)2.88326310
111mechanosensory behavior (GO:0007638)2.87930250
112centriole replication (GO:0007099)2.87646137
113cell differentiation in hindbrain (GO:0021533)2.87410717
114adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87154556
115gene silencing by RNA (GO:0031047)2.86583802
116multi-organism reproductive behavior (GO:0044705)2.86510638
117ionotropic glutamate receptor signaling pathway (GO:0035235)2.86491617
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86079679
119parental behavior (GO:0060746)2.85921920
120blood coagulation, intrinsic pathway (GO:0007597)2.84931793
121axonemal dynein complex assembly (GO:0070286)2.84672936
122negative regulation of thymocyte apoptotic process (GO:0070244)2.84569983
123synaptic vesicle maturation (GO:0016188)2.83680688
124neuron cell-cell adhesion (GO:0007158)2.82444052
125dopamine biosynthetic process (GO:0042416)2.81726572
126regulation of protein glycosylation (GO:0060049)2.80681474
127indole-containing compound metabolic process (GO:0042430)2.79877654
128regulation of synaptic vesicle transport (GO:1902803)2.79441906
129regulation of neurotransmitter levels (GO:0001505)2.78082728
130synaptic vesicle endocytosis (GO:0048488)2.77375102
131catecholamine metabolic process (GO:0006584)2.77354704
132catechol-containing compound metabolic process (GO:0009712)2.77354704
133multicellular organismal reproductive behavior (GO:0033057)2.77310414
134tachykinin receptor signaling pathway (GO:0007217)2.77291157
135regulation of glutamate receptor signaling pathway (GO:1900449)2.76907531
136kynurenine metabolic process (GO:0070189)2.76797349
137mannosylation (GO:0097502)2.76565505
138synaptic vesicle docking involved in exocytosis (GO:0016081)2.76487332
139peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.76177643
140regulation of female gonad development (GO:2000194)2.76143746
141regulation of neuronal synaptic plasticity (GO:0048168)2.75058414
142synaptic transmission, glutamatergic (GO:0035249)2.74889607
143negative regulation of amino acid transport (GO:0051956)2.74683730
144adenosine metabolic process (GO:0046085)2.74076201
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73993011
146regulation of synaptic transmission, dopaminergic (GO:0032225)2.73521889
147enteric nervous system development (GO:0048484)2.73337084
148regulation of secondary heart field cardioblast proliferation (GO:0003266)2.73297862
149regulation of cardioblast proliferation (GO:0003264)2.73297862
150negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.72231014
151acrosome assembly (GO:0001675)2.71586354
152fear response (GO:0042596)2.71356623
153reproductive behavior (GO:0019098)2.71097395
154regulation of glutamate secretion (GO:0014048)2.70229850
155positive regulation of vasculogenesis (GO:2001214)2.69940206
156regulation of synaptic transmission, glutamatergic (GO:0051966)2.68684345
157methionine biosynthetic process (GO:0009086)2.67397273
158aromatic amino acid family metabolic process (GO:0009072)2.67304728
159phospholipid homeostasis (GO:0055091)2.66588748
160neurotransmitter biosynthetic process (GO:0042136)2.66142908
161glutamate receptor signaling pathway (GO:0007215)2.65827660
162regulation of synapse structural plasticity (GO:0051823)2.65175180
163long-term memory (GO:0007616)2.62223952
164regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62156795
165auditory receptor cell stereocilium organization (GO:0060088)2.62125357
166innervation (GO:0060384)2.61790982
167benzene-containing compound metabolic process (GO:0042537)2.60724767
168behavioral response to cocaine (GO:0048148)2.60344121
169synapsis (GO:0007129)2.59977206
170primary amino compound metabolic process (GO:1901160)2.59913425
171glutathione derivative biosynthetic process (GO:1901687)2.58813734
172glutathione derivative metabolic process (GO:1901685)2.58813734
173negative regulation of norepinephrine secretion (GO:0010700)2.58317786
174transmission of nerve impulse (GO:0019226)2.56568564
175alanine transport (GO:0032328)2.56530181
176regulation of Golgi to plasma membrane protein transport (GO:0042996)2.56191068
177pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54502970
178negative regulation of calcium ion transport into cytosol (GO:0010523)2.53670351
179detection of chemical stimulus involved in sensory perception (GO:0050907)2.52197196
180regulation of lipoprotein metabolic process (GO:0050746)2.52132750
181sperm-egg recognition (GO:0035036)2.50067870
182regulation of establishment of cell polarity (GO:2000114)2.49303994
183negative regulation of heart rate (GO:0010459)2.48925719
184regulation of triglyceride catabolic process (GO:0010896)2.45797739
185relaxation of smooth muscle (GO:0044557)2.45745044
186amine biosynthetic process (GO:0009309)2.45465411
187ADP metabolic process (GO:0046031)2.45155748
188anterograde synaptic vesicle transport (GO:0048490)2.42284758
189cardiolipin metabolic process (GO:0032048)2.41547980
190cellular biogenic amine biosynthetic process (GO:0042401)2.41519274
191organelle membrane fusion (GO:0090174)2.39489261
192regulation of hippo signaling (GO:0035330)2.39452580
193regulation of cilium movement (GO:0003352)2.39332691
194methionine metabolic process (GO:0006555)2.38963078
195reproduction (GO:0000003)2.38457508
196synaptonemal complex assembly (GO:0007130)2.37907979
197protein K11-linked deubiquitination (GO:0035871)2.37612531
198double-strand break repair via homologous recombination (GO:0000724)2.37256075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68501859
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.58293805
3IGF1R_20145208_ChIP-Seq_DFB_Human3.42325768
4GBX2_23144817_ChIP-Seq_PC3_Human3.38170203
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13400539
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08146652
7VDR_22108803_ChIP-Seq_LS180_Human3.07777552
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99917733
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73289610
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64620907
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60594573
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56859178
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56859178
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44662499
15ZNF274_21170338_ChIP-Seq_K562_Hela2.43778446
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39878266
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30055953
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.26368308
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25774451
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.21598486
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.19409596
22AR_21572438_ChIP-Seq_LNCaP_Human2.13648736
23ER_23166858_ChIP-Seq_MCF-7_Human2.10942794
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.10592852
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.02598995
26NR3C1_23031785_ChIP-Seq_PC12_Mouse2.02152736
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99520813
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95697428
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.93856104
30EWS_26573619_Chip-Seq_HEK293_Human1.90655972
31REST_21632747_ChIP-Seq_MESCs_Mouse1.85560051
32TAF15_26573619_Chip-Seq_HEK293_Human1.84105437
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83336136
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82752343
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.80325285
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67724946
37DROSHA_22980978_ChIP-Seq_HELA_Human1.67281927
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64923484
39CBP_20019798_ChIP-Seq_JUKART_Human1.64883580
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64883580
41* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63114596
42SMAD4_21799915_ChIP-Seq_A2780_Human1.63035872
43P300_19829295_ChIP-Seq_ESCs_Human1.62048997
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61282089
45IRF1_19129219_ChIP-ChIP_H3396_Human1.61037503
46* PIAS1_25552417_ChIP-Seq_VCAP_Human1.60416164
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58905986
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57044305
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56347377
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54313856
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.52017236
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50651770
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49439332
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45109800
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42989606
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.42460541
57* RARB_27405468_Chip-Seq_BRAIN_Mouse1.42032563
58SCL_19346495_ChIP-Seq_HPC-7_Human1.41758343
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.40916362
60* SOX2_19829295_ChIP-Seq_ESCs_Human1.40485718
61* NANOG_19829295_ChIP-Seq_ESCs_Human1.40485718
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40401461
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40165045
64BCAT_22108803_ChIP-Seq_LS180_Human1.34476900
65TP53_22573176_ChIP-Seq_HFKS_Human1.33354476
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33080024
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32809128
68CDX2_22108803_ChIP-Seq_LS180_Human1.32034451
69TCF4_22108803_ChIP-Seq_LS180_Human1.31377716
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31053097
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29302422
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29302422
73* AR_20517297_ChIP-Seq_VCAP_Human1.28909118
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.28619705
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28023847
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27928686
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27648118
78AR_25329375_ChIP-Seq_VCAP_Human1.27264081
79* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25673262
80* FOXA1_25329375_ChIP-Seq_VCAP_Human1.25673262
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.25582002
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24997080
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23971109
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21505906
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21269999
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.20747025
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19526754
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.18506250
89* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18395808
90STAT3_23295773_ChIP-Seq_U87_Human1.17479258
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.17127533
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16703699
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.15073296
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14025839
95TP53_16413492_ChIP-PET_HCT116_Human1.13937414
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13048104
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12750285
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12105288
99TCF4_23295773_ChIP-Seq_U87_Human1.11891579
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.11175520
101TP53_18474530_ChIP-ChIP_U2OS_Human1.10821815
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.10411240
103PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09306479
104* GATA3_21878914_ChIP-Seq_MCF-7_Human1.09034418
105FUS_26573619_Chip-Seq_HEK293_Human1.08573161
106GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08144431
107* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08130373
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07195499
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07066617
110TRIM28_21343339_ChIP-Seq_HEK293_Human1.06930000
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06162652
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.05686745
113P53_22387025_ChIP-Seq_ESCs_Mouse1.05466794
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04960914
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.04813797
116* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04463227
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.03797168
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02950938
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02502441
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.01851937
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01749920
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01402229
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01080612
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01012088
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00434004
126* PRDM14_20953172_ChIP-Seq_ESCs_Human1.00287641
127MYC_18940864_ChIP-ChIP_HL60_Human1.00251069
128FLI1_21867929_ChIP-Seq_TH2_Mouse0.99700856
129* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99668681
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99621055
131JUN_21703547_ChIP-Seq_K562_Human0.99587397
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99582852
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99489778
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98570221
135RING1B_27294783_Chip-Seq_ESCs_Mouse0.98450193
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98399150
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98399150
138AHR_22903824_ChIP-Seq_MCF-7_Human0.98062217
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97310962
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97150649
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.96933836
142NCOR_22424771_ChIP-Seq_293T_Human0.96867871
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95946474
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.95780542
145AR_19668381_ChIP-Seq_PC3_Human0.95717026
146TBL1_22424771_ChIP-Seq_293T_Human0.94739905
147SALL4_22934838_ChIP-ChIP_CD34+_Human0.94174741
148NOTCH1_21737748_ChIP-Seq_TLL_Human0.93964307
149* NANOG_20526341_ChIP-Seq_ESCs_Human0.93676120
150RNF2_27304074_Chip-Seq_NSC_Mouse0.93567182
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.92730445
152* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91696908
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.90103633
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89795598
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88809251
156ESR2_21235772_ChIP-Seq_MCF-7_Human0.87790277
157* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87781629
158* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87188731
159GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86353487
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.85154576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.97617669
2MP0004859_abnormal_synaptic_plasticity4.38488095
3MP0002638_abnormal_pupillary_reflex4.01828623
4MP0010386_abnormal_urinary_bladder3.91889408
5MP0005464_abnormal_platelet_physiology3.91477062
6MP0003718_maternal_effect3.44376481
7MP0009745_abnormal_behavioral_response3.16200008
8MP0003635_abnormal_synaptic_transmissio3.06300738
9MP0004270_analgesia2.84891863
10MP0004858_abnormal_nervous_system2.84788825
11MP0008057_abnormal_DNA_replication2.78618406
12MP0002064_seizures2.69563160
13MP0009046_muscle_twitch2.62584117
14MP0001440_abnormal_grooming_behavior2.51592413
15MP0008004_abnormal_stomach_pH2.49244615
16MP0008877_abnormal_DNA_methylation2.44772078
17MP0002063_abnormal_learning/memory/cond2.41851362
18MP0005410_abnormal_fertilization2.40899712
19MP0000569_abnormal_digit_pigmentation2.37797660
20MP0002572_abnormal_emotion/affect_behav2.35755619
21MP0001905_abnormal_dopamine_level2.32477349
22MP0001501_abnormal_sleep_pattern2.30498280
23MP0001968_abnormal_touch/_nociception2.26252942
24MP0002735_abnormal_chemical_nociception2.26184276
25MP0003880_abnormal_central_pattern2.21795581
26MP0001529_abnormal_vocalization2.21210219
27MP0005551_abnormal_eye_electrophysiolog2.16982107
28MP0002734_abnormal_mechanical_nocicepti2.11317838
29MP0001970_abnormal_pain_threshold2.08043277
30MP0006276_abnormal_autonomic_nervous2.07083965
31MP0002733_abnormal_thermal_nociception1.99321989
32MP0002736_abnormal_nociception_after1.99230950
33MP0002272_abnormal_nervous_system1.94805465
34MP0003787_abnormal_imprinting1.93766859
35MP0004147_increased_porphyrin_level1.90570129
36MP0000465_gastrointestinal_hemorrhage1.81817951
37MP0004924_abnormal_behavior1.81606912
38MP0005386_behavior/neurological_phenoty1.81606912
39MP0001188_hyperpigmentation1.76834854
40MP0002067_abnormal_sensory_capabilities1.76266047
41MP0005503_abnormal_tendon_morphology1.73259305
42MP0001986_abnormal_taste_sensitivity1.70257791
43MP0002909_abnormal_adrenal_gland1.68135160
44MP0002184_abnormal_innervation1.65728004
45MP0001486_abnormal_startle_reflex1.61581865
46MP0000538_abnormal_urinary_bladder1.60798462
47MP0002138_abnormal_hepatobiliary_system1.57502396
48MP0008058_abnormal_DNA_repair1.56607361
49MP0000427_abnormal_hair_cycle1.55562215
50MP0005253_abnormal_eye_physiology1.53883020
51MP0003252_abnormal_bile_duct1.50716878
52MP0000230_abnormal_systemic_arterial1.47905095
53MP0001545_abnormal_hematopoietic_system1.46023729
54MP0005397_hematopoietic_system_phenotyp1.46023729
55MP0006054_spinal_hemorrhage1.44996091
56MP0009697_abnormal_copulation1.44729981
57MP0005360_urolithiasis1.44617067
58MP0003136_yellow_coat_color1.43383035
59MP0008569_lethality_at_weaning1.42648761
60MP0005646_abnormal_pituitary_gland1.41866455
61MP0003633_abnormal_nervous_system1.41295702
62MP0004043_abnormal_pH_regulation1.41003380
63MP0000383_abnormal_hair_follicle1.40948157
64MP0000778_abnormal_nervous_system1.39108506
65MP0001929_abnormal_gametogenesis1.37630791
66MP0005395_other_phenotype1.36092734
67MP0003698_abnormal_male_reproductive1.35989294
68MP0004084_abnormal_cardiac_muscle1.33573645
69MP0003806_abnormal_nucleotide_metabolis1.30947207
70MP0003950_abnormal_plasma_membrane1.29102940
71MP0005645_abnormal_hypothalamus_physiol1.28869507
72MP0000751_myopathy1.26882060
73MP0005085_abnormal_gallbladder_physiolo1.26415642
74MP0000955_abnormal_spinal_cord1.25806591
75MP0002160_abnormal_reproductive_system1.24053870
76MP0002557_abnormal_social/conspecific_i1.23369795
77MP0003656_abnormal_erythrocyte_physiolo1.23054238
78MP0008874_decreased_physiological_sensi1.22879545
79MP0003631_nervous_system_phenotype1.21776703
80MP0002653_abnormal_ependyma_morphology1.20720645
81MP0005174_abnormal_tail_pigmentation1.16078754
82MP0002090_abnormal_vision1.12936776
83MP0005409_darkened_coat_color1.12841686
84MP0006072_abnormal_retinal_apoptosis1.11400579
85MP0001764_abnormal_homeostasis1.11248811
86MP0008872_abnormal_physiological_respon1.10849103
87MP0008875_abnormal_xenobiotic_pharmacok1.10765005
88MP0000653_abnormal_sex_gland1.10416509
89MP0005083_abnormal_biliary_tract1.10188050
90MP0003122_maternal_imprinting1.09869810
91MP0004811_abnormal_neuron_physiology1.09636733
92MP0000015_abnormal_ear_pigmentation1.09344759
93MP0010329_abnormal_lipoprotein_level1.08793554
94MP0002751_abnormal_autonomic_nervous1.07198380
95MP0002876_abnormal_thyroid_physiology1.06568089
96MP0008775_abnormal_heart_ventricle1.06090158
97MP0000372_irregular_coat_pigmentation1.05708689
98MP0001666_abnormal_nutrient_absorption1.04360472
99MP0005084_abnormal_gallbladder_morpholo1.03492564
100MP0002066_abnormal_motor_capabilities/c1.02912219
101MP0003329_amyloid_beta_deposits1.01894330
102MP0006035_abnormal_mitochondrial_morpho1.00493770
103MP0005075_abnormal_melanosome_morpholog1.00351127
104MP0005670_abnormal_white_adipose0.99447625
105MP0005389_reproductive_system_phenotype0.99021037
106MP0005535_abnormal_body_temperature0.98179934
107MP0001661_extended_life_span0.97617140
108MP0004215_abnormal_myocardial_fiber0.96587479
109MP0003724_increased_susceptibility_to0.95667946
110MP0003879_abnormal_hair_cell0.95598162
111MP0002882_abnormal_neuron_morphology0.95290873
112MP0004510_myositis0.94762019
113MP0002102_abnormal_ear_morphology0.94588683
114MP0004036_abnormal_muscle_relaxation0.94297234
115MP0002210_abnormal_sex_determination0.93672351
116MP0006036_abnormal_mitochondrial_physio0.92276274
117MP0004484_altered_response_of0.92018995
118MP0005171_absent_coat_pigmentation0.91293298
119MP0001145_abnormal_male_reproductive0.90713354
120MP0005647_abnormal_sex_gland0.90032917
121MP0002132_abnormal_respiratory_system0.89885345
122MP0005197_abnormal_uvea_morphology0.88501012
123MP0010678_abnormal_skin_adnexa0.88372052
124MP0010094_abnormal_chromosome_stability0.85466033
125MP0004142_abnormal_muscle_tone0.85210346
126MP0003632_abnormal_nervous_system0.84531424
127MP0008995_early_reproductive_senescence0.83608723
128MP0002095_abnormal_skin_pigmentation0.82704632
129MP0009840_abnormal_foam_cell0.78701433
130MP0002139_abnormal_hepatobiliary_system0.78407675
131MP0003186_abnormal_redox_activity0.77932269
132MP0001963_abnormal_hearing_physiology0.77290589
133MP0002234_abnormal_pharynx_morphology0.74697026
134MP0004085_abnormal_heartbeat0.74464318
135MP0003868_abnormal_feces_composition0.74331163
136MP0009780_abnormal_chondrocyte_physiolo0.73529827
137MP0002152_abnormal_brain_morphology0.73516420
138MP0008438_abnormal_cutaneous_collagen0.72490716
139MP0003303_peritoneal_inflammation0.71765811
140MP0000013_abnormal_adipose_tissue0.71603260
141MP0001958_emphysema0.70219099
142MP0002069_abnormal_eating/drinking_beha0.69604465
143MP0003646_muscle_fatigue0.69095189
144MP0004742_abnormal_vestibular_system0.68123437
145MP0008961_abnormal_basal_metabolism0.67815877
146MP0001984_abnormal_olfaction0.67392525
147MP0008260_abnormal_autophagy0.66719470
148MP0002127_abnormal_cardiovascular_syste0.66369251
149MP0005623_abnormal_meninges_morphology0.64947518
150MP0003195_calcinosis0.64540521
151MP0001177_atelectasis0.64478731
152MP0002752_abnormal_somatic_nervous0.64005613
153MP0005499_abnormal_olfactory_system0.61799619
154MP0005394_taste/olfaction_phenotype0.61799619
155MP0005167_abnormal_blood-brain_barrier0.61484898
156MP0000026_abnormal_inner_ear0.60724826
157MP0002837_dystrophic_cardiac_calcinosis0.56659434
158MP0004130_abnormal_muscle_cell0.55784665
159MP0003634_abnormal_glial_cell0.55639109
160MP0005423_abnormal_somatic_nervous0.54612096
161MP0003075_altered_response_to0.54562366
162MP0001502_abnormal_circadian_rhythm0.53285621
163MP0000920_abnormal_myelination0.53012394
164MP0000049_abnormal_middle_ear0.51099946
165MP0010234_abnormal_vibrissa_follicle0.48767771
166MP0000631_abnormal_neuroendocrine_gland0.48398878
167MP0002332_abnormal_exercise_endurance0.47928848
168MP0000604_amyloidosis0.47258644
169MP0001270_distended_abdomen0.46727921
170MP0001943_abnormal_respiration0.46494731
171MP0001664_abnormal_digestion0.45834864

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)8.25869032
2Myokymia (HP:0002411)5.88427238
3Focal motor seizures (HP:0011153)5.79223191
4Orthostatic hypotension (HP:0001278)5.65567607
5Focal seizures (HP:0007359)4.97178322
6Febrile seizures (HP:0002373)4.48217536
7Prolonged bleeding time (HP:0003010)4.36399403
8Abnormal autonomic nervous system physiology (HP:0012332)4.33368253
9Amblyopia (HP:0000646)4.09255142
10Menorrhagia (HP:0000132)4.07049076
11Atonic seizures (HP:0010819)4.06689478
12Neonatal hypoglycemia (HP:0001998)4.03216359
13Generalized tonic-clonic seizures (HP:0002069)3.91765685
14Increased mean platelet volume (HP:0011877)3.77242292
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.74428110
16Exotropia (HP:0000577)3.74398145
17Petechiae (HP:0000967)3.62112325
18Action tremor (HP:0002345)3.60114528
19Pancreatic cysts (HP:0001737)3.59966899
20Abnormal ciliary motility (HP:0012262)3.50082670
21Hyperthyroidism (HP:0000836)3.42228838
22Type II lissencephaly (HP:0007260)3.42167977
23Abnormal platelet volume (HP:0011876)3.38181330
24Absence seizures (HP:0002121)3.36153895
25Supranuclear gaze palsy (HP:0000605)3.34623535
26Arthropathy (HP:0003040)3.30336776
27Agitation (HP:0000713)3.18904055
28Hypoventilation (HP:0002791)3.17726078
29Dialeptic seizures (HP:0011146)3.12618963
30Hyperlipoproteinemia (HP:0010980)3.11289955
31Abnormality of alanine metabolism (HP:0010916)3.09479854
32Hyperalaninemia (HP:0003348)3.09479854
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09479854
34Insidious onset (HP:0003587)3.08825080
35Termporal pattern (HP:0011008)3.08825080
36Pancreatic fibrosis (HP:0100732)3.07547524
37Abnormality of midbrain morphology (HP:0002418)3.06299725
38Molar tooth sign on MRI (HP:0002419)3.06299725
39Epistaxis (HP:0000421)3.04144582
40Abnormal respiratory epithelium morphology (HP:0012253)3.00809025
41Abnormal respiratory motile cilium morphology (HP:0005938)3.00809025
42Abnormal respiratory motile cilium physiology (HP:0012261)2.97375337
43Retinal dysplasia (HP:0007973)2.96932303
44Attenuation of retinal blood vessels (HP:0007843)2.91357212
45Progressive cerebellar ataxia (HP:0002073)2.88619542
46Limb dystonia (HP:0002451)2.85899603
47Visual hallucinations (HP:0002367)2.85796154
48Hyperventilation (HP:0002883)2.81726743
49Gingival bleeding (HP:0000225)2.80971918
50Decreased central vision (HP:0007663)2.78278191
51Cerebral inclusion bodies (HP:0100314)2.72850999
52Abnormality of macular pigmentation (HP:0008002)2.72375222
533-Methylglutaconic aciduria (HP:0003535)2.72316321
54Chronic hepatic failure (HP:0100626)2.70848536
55True hermaphroditism (HP:0010459)2.69780806
56Purpura (HP:0000979)2.68223080
57Depression (HP:0000716)2.59399226
58Genetic anticipation (HP:0003743)2.57297309
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57243249
60Abolished electroretinogram (ERG) (HP:0000550)2.55679419
61Abnormality of the renal cortex (HP:0011035)2.50720823
62Dyschromatopsia (HP:0007641)2.50496615
63Nephronophthisis (HP:0000090)2.50065366
64Hyperglycinemia (HP:0002154)2.48848282
65Central scotoma (HP:0000603)2.47574541
66Mitral stenosis (HP:0001718)2.45272388
67Torticollis (HP:0000473)2.43960934
68Epileptic encephalopathy (HP:0200134)2.43735731
69Abnormality of calcium-phosphate metabolism (HP:0100530)2.41624619
70Small epiphyses (HP:0010585)2.39058311
71Neurofibrillary tangles (HP:0002185)2.38040411
72Renal cortical cysts (HP:0000803)2.37754797
73Ulnar claw (HP:0001178)2.34856459
74Anxiety (HP:0000739)2.34702882
75Congenital sensorineural hearing impairment (HP:0008527)2.34614725
76Vertebral arch anomaly (HP:0008438)2.33745976
77Fair hair (HP:0002286)2.30398175
78Abnormality of the renal medulla (HP:0100957)2.29478183
79Hypotension (HP:0002615)2.25865184
80Medial flaring of the eyebrow (HP:0010747)2.25844249
81Abnormality of the prostate (HP:0008775)2.25710371
82Diplopia (HP:0000651)2.25306925
83Abnormality of binocular vision (HP:0011514)2.25306925
84Severe visual impairment (HP:0001141)2.24256298
85J-shaped sella turcica (HP:0002680)2.21894409
86Aqueductal stenosis (HP:0002410)2.20590214
87Cystic liver disease (HP:0006706)2.17809933
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.16882904
89Absent speech (HP:0001344)2.15011803
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13913505
91Abnormal protein N-linked glycosylation (HP:0012347)2.13913505
92Abnormal protein glycosylation (HP:0012346)2.13913505
93Abnormal glycosylation (HP:0012345)2.13913505
94Menstrual irregularities (HP:0000858)2.13874539
95Ketosis (HP:0001946)2.13765351
96Hyperglycinuria (HP:0003108)2.11074107
97Poikilocytosis (HP:0004447)2.07924578
98Abnormality of serine family amino acid metabolism (HP:0010894)2.07448434
99Abnormality of glycine metabolism (HP:0010895)2.07448434
100Tubulointerstitial nephritis (HP:0001970)2.06731289
101Dysautonomia (HP:0002459)2.06066945
102Dysmetria (HP:0001310)2.05883192
103Urinary bladder sphincter dysfunction (HP:0002839)2.04858058
104Ankle clonus (HP:0011448)2.04069183
105Thyroid-stimulating hormone excess (HP:0002925)2.02899086
106Lower limb amyotrophy (HP:0007210)2.02182845
107Congenital stationary night blindness (HP:0007642)2.01073492
108Recurrent corneal erosions (HP:0000495)1.99402221
109Abnormality of the corticospinal tract (HP:0002492)1.98368568
110Onion bulb formation (HP:0003383)1.98134090
111Wrist flexion contracture (HP:0001239)1.96905575
112Ketoacidosis (HP:0001993)1.94844236
113Focal dystonia (HP:0004373)1.94747159
114Distal lower limb amyotrophy (HP:0008944)1.94007184
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93379494
116Aplasia/Hypoplasia of the fovea (HP:0008060)1.93036658
117Hypoplasia of the fovea (HP:0007750)1.93036658
118Abnormality of the heme biosynthetic pathway (HP:0010472)1.92908148
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91039549
120Mixed hearing impairment (HP:0000410)1.90928109
121Narrow nasal bridge (HP:0000446)1.90892299
122Infertility (HP:0000789)1.89680543
123Striae distensae (HP:0001065)1.89296346
124Craniofacial dystonia (HP:0012179)1.89054603
125Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.88165507
126Subacute progressive viral hepatitis (HP:0006572)1.88048735
127Bony spicule pigmentary retinopathy (HP:0007737)1.86831188
128Pendular nystagmus (HP:0012043)1.86073891
129Congenital primary aphakia (HP:0007707)1.86033489
130Cerebellar dysplasia (HP:0007033)1.86003843
131Truncal ataxia (HP:0002078)1.85692163
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.85322441
133Round face (HP:0000311)1.85102795
134Hypercortisolism (HP:0001578)1.83122577
135Lower limb asymmetry (HP:0100559)1.82394033
136Lissencephaly (HP:0001339)1.82296402
137Impaired vibration sensation in the lower limbs (HP:0002166)1.79216718
138Anterior segment dysgenesis (HP:0007700)1.78215527
139Bile duct proliferation (HP:0001408)1.78039638
140Abnormal biliary tract physiology (HP:0012439)1.78039638
141Aplasia/Hypoplasia of the macula (HP:0008059)1.77744542
142Chronic sinusitis (HP:0011109)1.77480176
143Urinary urgency (HP:0000012)1.77473410
144Spastic gait (HP:0002064)1.76439757
145Gait imbalance (HP:0002141)1.76320164
146Hemiparesis (HP:0001269)1.75869355
147Nephrogenic diabetes insipidus (HP:0009806)1.75289650
148Scotoma (HP:0000575)1.75131620
149Epiphyseal dysplasia (HP:0002656)1.74248719
150Broad-based gait (HP:0002136)1.73410341
151Gaze-evoked nystagmus (HP:0000640)1.72854789
152Pheochromocytoma (HP:0002666)1.72680017
153Prolonged QT interval (HP:0001657)1.72624063
154Keratoconus (HP:0000563)1.72354705
155Increased corneal curvature (HP:0100692)1.72354705
156Abnormality of the fovea (HP:0000493)1.71748735
157Panhypogammaglobulinemia (HP:0003139)1.71510786
158Median cleft lip (HP:0000161)1.71113973
159Clumsiness (HP:0002312)1.70662303
160Postural tremor (HP:0002174)1.70552966
161Retinitis pigmentosa (HP:0000510)1.70338289
162Restlessness (HP:0000711)1.70327568
163Abnormality of lateral ventricle (HP:0030047)1.70237500
164Congenital hepatic fibrosis (HP:0002612)1.70042478
165Postural instability (HP:0002172)1.69288529
166Enlarged kidneys (HP:0000105)1.68766963
167Type I transferrin isoform profile (HP:0003642)1.68159526
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67341712
169Methylmalonic aciduria (HP:0012120)1.67260100
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.67192712
171Morphological abnormality of the middle ear (HP:0008609)1.67185337
172Psychosis (HP:0000709)1.67084923
173Acanthocytosis (HP:0001927)1.66708132
174Prostate neoplasm (HP:0100787)1.66381438
175Papilledema (HP:0001085)1.63777225
176Dynein arm defect of respiratory motile cilia (HP:0012255)1.63533903
177Absent/shortened dynein arms (HP:0200106)1.63533903
178Abnormality of pain sensation (HP:0010832)1.62155238
179Impaired pain sensation (HP:0007328)1.62155238
180Lip pit (HP:0100267)1.60944764
181Hyperphosphatemia (HP:0002905)1.60144265
182Autism (HP:0000717)1.59199494
183Drooling (HP:0002307)1.58977615
184Excessive salivation (HP:0003781)1.58977615
185Rhinitis (HP:0012384)1.58567044
186Poor eye contact (HP:0000817)1.58436584
187Upper limb muscle weakness (HP:0003484)1.58258619
188Bradycardia (HP:0001662)1.58005264
189Broad ribs (HP:0000885)1.57718886
190Testicular neoplasm (HP:0010788)1.57593051
191Palpebral edema (HP:0100540)1.57511628
192Hypocalcemia (HP:0002901)1.57421446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.72521725
2NTRK14.56823196
3RIPK43.74046241
4NTRK33.61418647
5BMPR1B3.34934592
6MAP3K43.30859678
7GRK73.25353063
8EPHA43.06723535
9MAP2K73.03926827
10TAOK32.70723381
11ADRBK22.54642693
12PIK3CG2.50984760
13PINK12.50010158
14TRIM282.43621615
15GRK52.42841771
16MAP4K22.34506941
17CDK192.29131259
18ACVR1B2.22814018
19NTRK22.19341143
20MATK2.13015085
21ZAK2.10841830
22NUAK12.02817866
23MST41.98556897
24PLK21.94453591
25DAPK21.93889251
26MAP3K91.87551888
27MAP2K41.86843721
28STK241.81284063
29TEC1.80909310
30SIK21.77656520
31CASK1.73494666
32FGR1.73155526
33MAP3K131.71768569
34WNK31.67869702
35MINK11.67362423
36PNCK1.55255482
37MYLK1.55204831
38ARAF1.48734557
39GRK61.38697371
40KSR21.37307405
41BCKDK1.34671498
42EIF2AK31.33868123
43FES1.32968127
44BMPR21.29992607
45STK38L1.28689577
46STK31.26812848
47WNK11.26108975
48EIF2AK11.22283337
49MAP3K121.19976616
50MARK31.18426971
51CDK51.17883336
52BCR1.15579162
53BTK1.13212898
54FLT31.10318190
55UHMK11.08523133
56TGFBR11.07914975
57OXSR11.07702888
58CSNK1G21.07548192
59TXK1.05762927
60ADRBK11.05743618
61MARK11.05359205
62PRPF4B1.03371654
63FER1.03029022
64PRKCG1.01567883
65PRKCE1.00938433
66PAK61.00146174
67MAP2K10.95422282
68CDK80.95069267
69MAPKAPK30.92501269
70CAMKK10.90297150
71CAMK2A0.86923689
72MAPKAPK50.85762700
73PTK2B0.84884254
74DDR20.82634850
75LATS20.80308033
76LATS10.78994025
77STK110.77764219
78CAMK2B0.77288959
79CAMK1G0.76322244
80MAP3K20.76005613
81MAPK130.75702542
82CSNK1G30.75212676
83TNK20.74707758
84DAPK10.72454622
85KIT0.71730675
86PRKCH0.71616593
87BMX0.70630364
88DYRK1A0.68505241
89SIK30.68203581
90PAK30.66432893
91STK380.65146676
92JAK10.63444078
93SGK4940.62993875
94SGK2230.62993875
95CSF1R0.61745324
96PIK3CA0.60713230
97FYN0.59385134
98BRSK20.58951558
99ERBB30.57907214
100TRPM70.54455224
101MAP3K50.54080802
102AKT30.53837159
103CAMK2G0.53639455
104ITK0.53197983
105TLK10.53012708
106CSNK1D0.51835337
107MUSK0.51736527
108MAP3K10.51155053
109YES10.50989920
110CAMKK20.48941088
111PRKCQ0.48475762
112VRK10.48078289
113PLK40.47370852
114PBK0.46512395
115STK390.46511299
116PLK30.46495090
117MAPK110.46477374
118IKBKB0.46471212
119MAP3K140.46288483
120PDGFRA0.46034690
121SRC0.45945663
122SGK10.45422564
123LYN0.44153930
124CAMK10.44073519
125RIPK10.43007513
126RET0.42589981
127INSRR0.41977217
128ATM0.41791146
129CAMK2D0.41602746
130MARK20.41318288
131ATR0.41294769
132SYK0.40759862
133CDC42BPA0.40510715
134GRK10.40152468
135LMTK20.39939232
136CSNK1G10.39070614
137PKN10.38092167
138TYRO30.37948130
139CSNK1A1L0.37145844
140TNIK0.37121106
141ROCK20.37111951
142CCNB10.37056106
143PHKG20.36514671
144PHKG10.36514671
145CDK150.35980326
146PDGFRB0.35957139
147CDK180.35729301
148EPHB20.34730178
149EPHA30.34713867
150PRKG10.34504131
151INSR0.34059062
152PRKCZ0.33567125
153PRKACA0.33173468
154PRKCB0.33032141
155MKNK20.31905998
156PLK10.31354144
157MKNK10.30623468
158TIE10.30250181
159CDK90.30227373
160STK160.29872741
161PRKCA0.29794787
162DYRK30.29307906
163ABL10.29206771
164PIM10.28341633

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.87235369
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.74631478
3Butanoate metabolism_Homo sapiens_hsa006502.74089547
4Amphetamine addiction_Homo sapiens_hsa050312.40954895
5Synaptic vesicle cycle_Homo sapiens_hsa047212.40216022
6Nitrogen metabolism_Homo sapiens_hsa009102.35292018
7Cocaine addiction_Homo sapiens_hsa050302.30577826
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.29893051
9Olfactory transduction_Homo sapiens_hsa047402.29073071
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.23311384
11Nicotine addiction_Homo sapiens_hsa050332.20514053
12Serotonergic synapse_Homo sapiens_hsa047262.17881250
13Dopaminergic synapse_Homo sapiens_hsa047282.16433076
14Circadian entrainment_Homo sapiens_hsa047132.14398223
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.11900251
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11393923
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08698153
18Linoleic acid metabolism_Homo sapiens_hsa005912.06868955
19Homologous recombination_Homo sapiens_hsa034402.05586033
20Cholinergic synapse_Homo sapiens_hsa047252.03323049
21Glutamatergic synapse_Homo sapiens_hsa047242.02224068
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96878318
23Salivary secretion_Homo sapiens_hsa049701.93194197
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90970818
25Renin secretion_Homo sapiens_hsa049241.90381074
26Long-term depression_Homo sapiens_hsa047301.89290454
27ABC transporters_Homo sapiens_hsa020101.87141049
28Long-term potentiation_Homo sapiens_hsa047201.83609918
29Fanconi anemia pathway_Homo sapiens_hsa034601.79478025
30Phenylalanine metabolism_Homo sapiens_hsa003601.78911650
31Morphine addiction_Homo sapiens_hsa050321.78571090
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76440864
33Chemical carcinogenesis_Homo sapiens_hsa052041.69877759
34Taste transduction_Homo sapiens_hsa047421.68192713
35Arachidonic acid metabolism_Homo sapiens_hsa005901.67604448
36Insulin secretion_Homo sapiens_hsa049111.67307842
37Tryptophan metabolism_Homo sapiens_hsa003801.66908723
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66348793
39Propanoate metabolism_Homo sapiens_hsa006401.66212668
40Collecting duct acid secretion_Homo sapiens_hsa049661.65878088
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.65746036
42Non-homologous end-joining_Homo sapiens_hsa034501.64866746
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63231262
44African trypanosomiasis_Homo sapiens_hsa051431.61602097
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59967027
46GnRH signaling pathway_Homo sapiens_hsa049121.55398887
47GABAergic synapse_Homo sapiens_hsa047271.52673200
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52226643
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49714879
50Tyrosine metabolism_Homo sapiens_hsa003501.49340020
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47526447
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44767741
53Gastric acid secretion_Homo sapiens_hsa049711.42724936
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41718041
55Retinol metabolism_Homo sapiens_hsa008301.41698199
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35887868
57Calcium signaling pathway_Homo sapiens_hsa040201.35276267
58Mismatch repair_Homo sapiens_hsa034301.34577962
59Basal transcription factors_Homo sapiens_hsa030221.33887021
60Peroxisome_Homo sapiens_hsa041461.32940203
61Oxytocin signaling pathway_Homo sapiens_hsa049211.32226682
62Pancreatic secretion_Homo sapiens_hsa049721.28055187
63Gap junction_Homo sapiens_hsa045401.27760560
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24463013
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20657714
66Glutathione metabolism_Homo sapiens_hsa004801.19059299
67cAMP signaling pathway_Homo sapiens_hsa040241.14999678
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14137359
69Dorso-ventral axis formation_Homo sapiens_hsa043201.14014649
70Fatty acid elongation_Homo sapiens_hsa000621.13478075
71Vascular smooth muscle contraction_Homo sapiens_hsa042701.11723591
72Type II diabetes mellitus_Homo sapiens_hsa049301.10317241
73Estrogen signaling pathway_Homo sapiens_hsa049151.09991612
74Histidine metabolism_Homo sapiens_hsa003401.09984657
75Ether lipid metabolism_Homo sapiens_hsa005651.09085172
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07995336
77RNA polymerase_Homo sapiens_hsa030201.05117229
78beta-Alanine metabolism_Homo sapiens_hsa004101.02771103
79Maturity onset diabetes of the young_Homo sapiens_hsa049501.01642450
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00623712
81Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00010919
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96991549
83Purine metabolism_Homo sapiens_hsa002300.96481200
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95174618
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.94124517
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90921194
87Regulation of autophagy_Homo sapiens_hsa041400.89899557
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89178142
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88541739
90Vibrio cholerae infection_Homo sapiens_hsa051100.88002351
91Rheumatoid arthritis_Homo sapiens_hsa053230.86822442
92Fatty acid metabolism_Homo sapiens_hsa012120.84281801
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83929303
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82709944
95Pyrimidine metabolism_Homo sapiens_hsa002400.82464261
96Melanogenesis_Homo sapiens_hsa049160.82087731
97Sphingolipid metabolism_Homo sapiens_hsa006000.81473124
98Fatty acid biosynthesis_Homo sapiens_hsa000610.79619738
99Nucleotide excision repair_Homo sapiens_hsa034200.79405928
100Choline metabolism in cancer_Homo sapiens_hsa052310.79010644
101Ovarian steroidogenesis_Homo sapiens_hsa049130.77676064
102Type I diabetes mellitus_Homo sapiens_hsa049400.77415739
103Axon guidance_Homo sapiens_hsa043600.76672393
104Base excision repair_Homo sapiens_hsa034100.75845866
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75126231
106Fatty acid degradation_Homo sapiens_hsa000710.74471895
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74401540
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.72888675
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.72772147
110Primary immunodeficiency_Homo sapiens_hsa053400.72118627
111Glioma_Homo sapiens_hsa052140.70329352
112Systemic lupus erythematosus_Homo sapiens_hsa053220.69861277
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69735197
114Hematopoietic cell lineage_Homo sapiens_hsa046400.69198976
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.68919917
116Thyroid hormone synthesis_Homo sapiens_hsa049180.67229282
117Amoebiasis_Homo sapiens_hsa051460.67014787
118One carbon pool by folate_Homo sapiens_hsa006700.66667027
119ErbB signaling pathway_Homo sapiens_hsa040120.66592513
120Phagosome_Homo sapiens_hsa041450.66500361
121Alzheimers disease_Homo sapiens_hsa050100.66273092
122Metabolic pathways_Homo sapiens_hsa011000.66218712
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60989874
124Fat digestion and absorption_Homo sapiens_hsa049750.60770299
125VEGF signaling pathway_Homo sapiens_hsa043700.60195161
126Dilated cardiomyopathy_Homo sapiens_hsa054140.59948913
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57735779
128Caffeine metabolism_Homo sapiens_hsa002320.57601236
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57401090
130Rap1 signaling pathway_Homo sapiens_hsa040150.57257462
131N-Glycan biosynthesis_Homo sapiens_hsa005100.57201335
132Alcoholism_Homo sapiens_hsa050340.57085937
133Chemokine signaling pathway_Homo sapiens_hsa040620.56850588
134Tuberculosis_Homo sapiens_hsa051520.56686806
135Circadian rhythm_Homo sapiens_hsa047100.56110609
136PPAR signaling pathway_Homo sapiens_hsa033200.56000865
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.55931122
138MAPK signaling pathway_Homo sapiens_hsa040100.55927751
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55800628
140Graft-versus-host disease_Homo sapiens_hsa053320.55380996
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53961198
142Ras signaling pathway_Homo sapiens_hsa040140.52968570
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.52849833
144Mineral absorption_Homo sapiens_hsa049780.52453738
145Platelet activation_Homo sapiens_hsa046110.52414757
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52339949
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52149243
148Malaria_Homo sapiens_hsa051440.51150073
149Bile secretion_Homo sapiens_hsa049760.50710397
150Complement and coagulation cascades_Homo sapiens_hsa046100.49869647
151Inositol phosphate metabolism_Homo sapiens_hsa005620.49737932
152Starch and sucrose metabolism_Homo sapiens_hsa005000.49312789
153Prion diseases_Homo sapiens_hsa050200.48154078
154Intestinal immune network for IgA production_Homo sapiens_hsa046720.46912283
155Leishmaniasis_Homo sapiens_hsa051400.45359765
156Osteoclast differentiation_Homo sapiens_hsa043800.45090075
157Selenocompound metabolism_Homo sapiens_hsa004500.44799128
158Protein export_Homo sapiens_hsa030600.44175796
159B cell receptor signaling pathway_Homo sapiens_hsa046620.43751349
160Cardiac muscle contraction_Homo sapiens_hsa042600.42802679
161Oxidative phosphorylation_Homo sapiens_hsa001900.42501738
162Phototransduction_Homo sapiens_hsa047440.42049444
163RNA degradation_Homo sapiens_hsa030180.41902429
164Oocyte meiosis_Homo sapiens_hsa041140.41842634
165Pertussis_Homo sapiens_hsa051330.40518265
166Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40482190
167Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40008842
168Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39926265
169Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38140703
170Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37930531
171Glycerolipid metabolism_Homo sapiens_hsa005610.37801514
172Wnt signaling pathway_Homo sapiens_hsa043100.37473819
173Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36933608
174Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36289862
175Salmonella infection_Homo sapiens_hsa051320.36009585
176Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34775735

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