TMC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)7.60531558
2intestinal absorption (GO:0050892)7.12674687
3positive regulation of interferon-gamma biosynthetic process (GO:0045078)7.02580891
4DNA strand renaturation (GO:0000733)6.96119151
5negative regulation of cell aging (GO:0090344)6.87771197
6cellular response to ATP (GO:0071318)6.53363604
7innate immune response in mucosa (GO:0002227)6.50194632
8regulation of skeletal muscle contraction (GO:0014819)6.48936163
9positive regulation of protein kinase C signaling (GO:0090037)6.20407746
10fusion of sperm to egg plasma membrane (GO:0007342)5.92183703
11purinergic nucleotide receptor signaling pathway (GO:0035590)5.83354356
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.81021050
13T-helper 1 type immune response (GO:0042088)5.79600677
14intestinal cholesterol absorption (GO:0030299)5.66046379
15adenosine receptor signaling pathway (GO:0001973)5.46190253
16bile acid and bile salt transport (GO:0015721)5.36732858
17mucosal immune response (GO:0002385)5.34921650
18meiotic chromosome segregation (GO:0045132)5.27862816
19regulation of interferon-gamma biosynthetic process (GO:0045072)5.24690432
20maintenance of gastrointestinal epithelium (GO:0030277)5.23521128
21rRNA methylation (GO:0031167)5.16294337
22sperm motility (GO:0030317)5.15371516
23cell wall macromolecule catabolic process (GO:0016998)5.04231442
24cell wall macromolecule metabolic process (GO:0044036)5.04231442
25UDP-N-acetylglucosamine metabolic process (GO:0006047)5.00698615
26sperm capacitation (GO:0048240)4.92240244
27angiotensin maturation (GO:0002003)4.90834750
28acrosome assembly (GO:0001675)4.90518865
29organ or tissue specific immune response (GO:0002251)4.81420915
30regulation of bile acid biosynthetic process (GO:0070857)4.78790081
31axonemal dynein complex assembly (GO:0070286)4.76622148
32lens fiber cell differentiation (GO:0070306)4.76545740
33multicellular organism reproduction (GO:0032504)4.73468212
34diol metabolic process (GO:0034311)4.69015186
35immunoglobulin mediated immune response (GO:0016064)4.64651431
36positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.63962257
37cilium or flagellum-dependent cell motility (GO:0001539)4.63496692
38regulation of synapse structural plasticity (GO:0051823)4.63485956
39acrosome reaction (GO:0007340)4.59747793
40chromatin assembly (GO:0031497)4.55540727
41regulation of keratinocyte proliferation (GO:0010837)4.54715272
42rRNA modification (GO:0000154)4.49185805
43mitotic cell cycle arrest (GO:0071850)4.41135273
44intestinal epithelial cell development (GO:0060576)4.38427276
45sulfate transmembrane transport (GO:1902358)4.37823766
46regulation of protein kinase A signaling (GO:0010738)4.34794778
47adenine nucleotide transport (GO:0051503)4.32135232
48negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.30391496
49purine ribonucleotide transport (GO:0015868)4.29778779
50plasma membrane fusion (GO:0045026)4.28870023
51bundle of His cell to Purkinje myocyte communication (GO:0086069)4.25106153
52sphingosine metabolic process (GO:0006670)4.24757513
53purinergic receptor signaling pathway (GO:0035587)4.22822512
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.18183148
55negative regulation of B cell apoptotic process (GO:0002903)4.11293338
56purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.10718555
573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.10718555
58negative regulation of keratinocyte proliferation (GO:0010839)4.10631064
59pyrimidine-containing compound transmembrane transport (GO:0072531)4.09987545
60sperm-egg recognition (GO:0035036)4.07875354
61nucleosome assembly (GO:0006334)4.05902651
62cell-cell recognition (GO:0009988)4.05685339
63proline biosynthetic process (GO:0006561)3.99403095
64flavonoid metabolic process (GO:0009812)3.98719866
65piRNA metabolic process (GO:0034587)3.96419904
66epithelial cilium movement (GO:0003351)3.94222885
67microtubule depolymerization (GO:0007019)3.94065847
68digestive system process (GO:0022600)3.92643374
69DNA replication-dependent nucleosome organization (GO:0034723)3.89803135
70DNA replication-dependent nucleosome assembly (GO:0006335)3.89803135
71regulation of interferon-beta biosynthetic process (GO:0045357)3.89256164
72sphingoid metabolic process (GO:0046519)3.87842885
73CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.87196530
74motile cilium assembly (GO:0044458)3.84518581
75sulfate transport (GO:0008272)3.80601627
76vitamin transmembrane transport (GO:0035461)3.78629934
77peptidyl-glutamic acid carboxylation (GO:0017187)3.77409530
78protein carboxylation (GO:0018214)3.77409530
79reproduction (GO:0000003)3.76764630
80UV protection (GO:0009650)3.76076053
81B cell mediated immunity (GO:0019724)3.73110793
82spermatid development (GO:0007286)3.72695585
83regulation of respiratory burst (GO:0060263)3.71842321
84vitamin A metabolic process (GO:0006776)3.69959819
85desmosome organization (GO:0002934)3.68191980
86O-glycan processing (GO:0016266)3.67258701
87male meiosis (GO:0007140)3.63435956
88cilium movement (GO:0003341)3.63204677
89epithelial structure maintenance (GO:0010669)3.61714315
90sensory perception of taste (GO:0050909)3.60376391
91drug catabolic process (GO:0042737)3.60001735
92sulfur compound transport (GO:0072348)3.59803850
93antigen processing and presentation of endogenous antigen (GO:0019883)3.59411661
94regulation of protein glycosylation (GO:0060049)3.59070021
95positive regulation of T cell mediated cytotoxicity (GO:0001916)3.57462110
96B cell homeostasis (GO:0001782)3.54929576
97positive regulation of interferon-alpha production (GO:0032727)3.53336239
98positive regulation of macrophage cytokine production (GO:0060907)3.53227850
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51103984
100regulation of cell aging (GO:0090342)3.47945095
101positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.46653593
102binding of sperm to zona pellucida (GO:0007339)3.45416907
103nucleoside transmembrane transport (GO:1901642)3.44725382
104positive regulation of heat generation (GO:0031652)3.43273118
105protein-DNA complex assembly (GO:0065004)3.41456823
106G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.41098273
107striated muscle atrophy (GO:0014891)3.38851825
108monoubiquitinated protein deubiquitination (GO:0035520)3.36982713
109response to ATP (GO:0033198)3.35819362
110regulation of cytokine production involved in inflammatory response (GO:1900015)3.34814189
111positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33523404
112nucleotide-sugar biosynthetic process (GO:0009226)3.32930428
113regulation of hydrogen peroxide metabolic process (GO:0010310)3.32407273
114estrogen biosynthetic process (GO:0006703)3.30724535
115melanin biosynthetic process (GO:0042438)3.29056444
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25897067
117positive regulation of humoral immune response (GO:0002922)3.25805183
118regulation of interferon-alpha production (GO:0032647)3.25310101
119negative regulation of protein tyrosine kinase activity (GO:0061099)3.24393189
120nucleotide transmembrane transport (GO:1901679)3.21910633
121nucleosome organization (GO:0034728)3.21788787
122response to hydroperoxide (GO:0033194)3.21354327
123single fertilization (GO:0007338)3.20005089
124purine nucleotide transport (GO:0015865)3.19899028
125positive regulation of protein homooligomerization (GO:0032464)3.19330942
126urinary tract smooth muscle contraction (GO:0014848)3.17423407
127regulation of B cell apoptotic process (GO:0002902)3.15872559
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.15838992
129interferon-gamma-mediated signaling pathway (GO:0060333)3.15054950
130melanin metabolic process (GO:0006582)3.14655858
131regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.14464978
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14142132
133tRNA modification (GO:0006400)3.14057349
134cellular response to virus (GO:0098586)3.11847735
135actin filament depolymerization (GO:0030042)3.08952634
136DNA replication checkpoint (GO:0000076)3.07339071
137negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.05774347
138B cell receptor signaling pathway (GO:0050853)3.05128137
139positive regulation of interferon-gamma production (GO:0032729)3.02391662
140positive regulation of glycoprotein biosynthetic process (GO:0010560)3.00875595
141B cell proliferation (GO:0042100)3.00423272
142negative regulation of epidermal cell differentiation (GO:0045605)2.98613943
143regulation of keratinocyte differentiation (GO:0045616)2.98485912
144peristalsis (GO:0030432)2.98197049
145regulation of T cell mediated cytotoxicity (GO:0001914)2.97574489
146antibacterial humoral response (GO:0019731)2.97439164
147regulation of hippo signaling (GO:0035330)2.96289412
148amino-acid betaine transport (GO:0015838)2.95963697
149carnitine transport (GO:0015879)2.95963697
150DNA deamination (GO:0045006)2.95352600
151regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94482688
152transepithelial transport (GO:0070633)2.94419020
153fertilization (GO:0009566)2.92530541
154glucose catabolic process (GO:0006007)2.92522370
155meiotic cell cycle (GO:0051321)2.92497653
156detection of bacterium (GO:0016045)2.91992832
157regulation of B cell proliferation (GO:0030888)2.91445022
158granulocyte differentiation (GO:0030851)2.91372083
159notochord development (GO:0030903)2.91090284
160pseudouridine synthesis (GO:0001522)2.90557038
161hemidesmosome assembly (GO:0031581)2.90445085
162histone phosphorylation (GO:0016572)2.89437557
163inner cell mass cell proliferation (GO:0001833)2.88018472
164carnitine transmembrane transport (GO:1902603)2.87315716
165positive regulation of triglyceride lipase activity (GO:0061365)2.87169205
166positive regulation of lipoprotein lipase activity (GO:0051006)2.87169205
167calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.87114879
168positive regulation of B cell proliferation (GO:0030890)2.86442019
169regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.86251287
170protein insertion into membrane (GO:0051205)2.86227700
171chaperone mediated protein folding requiring cofactor (GO:0051085)2.85861782
172male meiosis I (GO:0007141)2.85593691
173skeletal muscle adaptation (GO:0043501)2.85410322
174phosphatidylcholine biosynthetic process (GO:0006656)2.84717833
175spermatogenesis (GO:0007283)2.84443623
176muscle atrophy (GO:0014889)2.84301690
177bicarbonate transport (GO:0015701)2.84237113
178regulation of guanylate cyclase activity (GO:0031282)2.83797139
179response to UV-C (GO:0010225)2.83075647
180phosphatidylglycerol biosynthetic process (GO:0006655)2.82923884
181regulation of phospholipid biosynthetic process (GO:0071071)2.82793459
182male gamete generation (GO:0048232)2.82606887
183regulation of establishment or maintenance of cell polarity (GO:0032878)2.82281877
184pentose metabolic process (GO:0019321)2.81277625
185antimicrobial humoral response (GO:0019730)2.81172102
186glycerol metabolic process (GO:0006071)2.80020806
187regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78059777
188interferon-gamma secretion (GO:0072643)2.75715157
189lipoprotein transport (GO:0042953)2.74261479
190tight junction assembly (GO:0070830)2.73615688
191pentose-phosphate shunt (GO:0006098)2.73049022
192glucose 6-phosphate metabolic process (GO:0051156)2.72658037
193response to hepatocyte growth factor (GO:0035728)2.72084726
194cellular response to hepatocyte growth factor stimulus (GO:0035729)2.72084726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.39180479
2TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse4.25521601
3VDR_21846776_ChIP-Seq_THP-1_Human4.08568136
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.90161215
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.84818157
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.48230268
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.75150911
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64386850
9LXR_22292898_ChIP-Seq_THP-1_Human2.59054042
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56202612
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.55890079
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.51106919
13MAF_26560356_Chip-Seq_TH1_Human2.43654468
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.38894748
15P68_20966046_ChIP-Seq_HELA_Human2.34585909
16* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.32133075
17MYC_22102868_ChIP-Seq_BL_Human2.25637887
18MAF_26560356_Chip-Seq_TH2_Human2.20096133
19KAP1_22055183_ChIP-Seq_ESCs_Mouse2.17490345
20VDR_24763502_ChIP-Seq_THP-1_Human2.15428639
21XRN2_22483619_ChIP-Seq_HELA_Human2.14813312
22GATA4_25053715_ChIP-Seq_YYC3_Human2.13815918
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.11143681
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05740588
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.04914954
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01558506
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.99531098
28BCOR_27268052_Chip-Seq_Bcells_Human1.98383035
29BCL6_27268052_Chip-Seq_Bcells_Human1.95847076
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.92141284
31* GATA6_25053715_ChIP-Seq_YYC3_Human1.91844932
32E2F1_20622854_ChIP-Seq_HELA_Human1.81535371
33STAT1_17558387_ChIP-Seq_HELA_Human1.79000485
34UTX_26944678_Chip-Seq_JUKART_Human1.78382254
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76569745
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.73118888
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.70796785
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68802752
39RACK7_27058665_Chip-Seq_MCF-7_Human1.68060691
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66080157
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65382544
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65264792
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65200178
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64034620
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60075983
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58652652
47MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.55421037
48PHF8_20622854_ChIP-Seq_HELA_Human1.55258773
49SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.53256376
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52897728
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52418875
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51707550
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51473827
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51166249
55CIITA_25753668_ChIP-Seq_RAJI_Human1.50945808
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50765363
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.49971532
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.49437546
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49101756
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47667450
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46279172
62RARB_24833708_ChIP-Seq_LIVER_Mouse1.45082314
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.44252288
64GATA1_22025678_ChIP-Seq_K562_Human1.44185992
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43936193
66VDR_22108803_ChIP-Seq_LS180_Human1.42404144
67RARA_24833708_ChIP-Seq_LIVER_Mouse1.41436001
68KLF5_25053715_ChIP-Seq_YYC3_Human1.41280627
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.40801964
70CTCF_27219007_Chip-Seq_Bcells_Human1.38206545
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.38053554
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37623283
73* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.37548637
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37424595
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37422984
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37422984
77ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36920919
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36443426
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36115664
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.35090116
81FOXP1_21924763_ChIP-Seq_HESCs_Human1.34240308
82KDM2B_26808549_Chip-Seq_DND41_Human1.33814356
83CDX2_22108803_ChIP-Seq_LS180_Human1.33434008
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32155684
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31742485
86CTCF_21964334_Chip-Seq_Bcells_Human1.31666740
87* SOX2_20726797_ChIP-Seq_SW620_Human1.31060672
88RUNX1_26923725_Chip-Seq_HPCs_Mouse1.30673887
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30593096
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29268081
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.28893041
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.28854117
93* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28318581
94* LXR_22158963_ChIP-Seq_LIVER_Mouse1.28115412
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27620990
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.27272604
97TCF7_22412390_ChIP-Seq_EML_Mouse1.26809919
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25648205
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25373526
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24166016
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23168683
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22347283
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21950724
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.21466107
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.21157915
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.20698652
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20065245
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.18154737
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18130523
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17553759
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16605912
112ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16342937
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16231917
114TP53_22127205_ChIP-Seq_IMR90_Human1.14878071
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.14706377
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14636135
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14359895
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14268067
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.13897531
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13053813
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12662945
122ETS1_21867929_ChIP-Seq_TH2_Mouse1.12589467
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12440277
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12434018
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12403211
126RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12106149
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.12066684
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11876277
129SMC4_20622854_ChIP-Seq_HELA_Human1.10902335
130TBL1_22424771_ChIP-Seq_293T_Human1.10893576
131CREB1_26743006_Chip-Seq_LNCaP_Human1.10562616
132DCP1A_22483619_ChIP-Seq_HELA_Human1.10492347
133P300_27268052_Chip-Seq_Bcells_Human1.09912564
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09499665
135FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08996843
136TP53_16413492_ChIP-PET_HCT116_Human1.08941746
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08565578
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08071153
139FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08039844
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07723017
141* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07447165
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07198591
143UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07146639
144OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07035593
145STAT3_18555785_Chip-Seq_ESCs_Mouse1.06500836
146GF1_26923725_Chip-Seq_HPCs_Mouse1.06290425
147UBF1/2_26484160_Chip-Seq_HMECs_Human1.06202994
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05866330
149KDM2B_26808549_Chip-Seq_REH_Human1.05124078
150IRF8_21731497_ChIP-ChIP_J774_Mouse1.05121534
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04588892
152SOX2_18555785_Chip-Seq_ESCs_Mouse1.04332933
153* SMAD3_21741376_ChIP-Seq_HESCs_Human1.04203612
154ERG_21242973_ChIP-ChIP_JURKAT_Human1.03852826
155* CTCF_20526341_ChIP-Seq_ESCs_Human1.03838003
156* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03776619
157BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03760613
158CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03088120
159PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02792688
160* ATF3_27146783_Chip-Seq_COLON_Human1.02711932
161VDR_23849224_ChIP-Seq_CD4+_Human1.02155886
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01947903
163P53_22387025_ChIP-Seq_ESCs_Mouse1.01626043
164VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01432587
165CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01157028
166NCOR1_26117541_ChIP-Seq_K562_Human1.00686312
167EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00635524
168TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00279773
169PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00197024
170OCT4_18555785_Chip-Seq_ESCs_Mouse1.00135611
171FOXA1_25552417_ChIP-Seq_VCAP_Human0.99038779
172FOXO3_23340844_ChIP-Seq_DLD1_Human0.98850907
173E2F1_18555785_Chip-Seq_ESCs_Mouse0.98277152
174ETV1_20927104_ChIP-Seq_GIST48_Human0.97851929
175P300_18555785_Chip-Seq_ESCs_Mouse0.96715749
176KLF4_18555785_Chip-Seq_ESCs_Mouse0.96677682
177ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96085467
178CRX_20693478_ChIP-Seq_RETINA_Mouse0.95322593
179NFYA_21822215_ChIP-Seq_K562_Human0.94938026
180CMYC_18555785_Chip-Seq_ESCs_Mouse0.94364553
181CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92901542
182SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91674410
183SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91558670
184NFYB_21822215_ChIP-Seq_K562_Human0.90684393
185* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90528896
186ESR2_21235772_ChIP-Seq_MCF-7_Human0.90236063
187CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89526132
188AHR_22903824_ChIP-Seq_MCF-7_Human0.89327831
189PIAS1_25552417_ChIP-Seq_VCAP_Human0.89244195
190PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88930802
191* GATA3_21867929_ChIP-Seq_CD8_Mouse0.88116004
192RXR_22158963_ChIP-Seq_LIVER_Mouse0.87965058
193ZFX_18555785_Chip-Seq_ESCs_Mouse0.87192101
194HNF4A_19822575_ChIP-Seq_HepG2_Human0.86806475
195HNFA_21074721_ChIP-Seq_CACO-2_Human0.86621010
196CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86257024
197* FOXA2_19822575_ChIP-Seq_HepG2_Human0.85610235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.95047563
2MP0005171_absent_coat_pigmentation6.25048326
3MP0005360_urolithiasis5.89467169
4MP0001986_abnormal_taste_sensitivity5.40650050
5MP0005423_abnormal_somatic_nervous5.24384825
6MP0004264_abnormal_extraembryonic_tissu4.55168644
7MP0005410_abnormal_fertilization4.54783721
8MP0003136_yellow_coat_color4.36647405
9MP0005645_abnormal_hypothalamus_physiol4.18820958
10MP0000462_abnormal_digestive_system3.85258108
11MP0000685_abnormal_immune_system3.70953887
12MP0001666_abnormal_nutrient_absorption3.53476821
13MP0002102_abnormal_ear_morphology2.72753899
14MP0005377_hearing/vestibular/ear_phenot2.68086771
15MP0003878_abnormal_ear_physiology2.68086771
16MP0009840_abnormal_foam_cell2.67539878
17MP0005085_abnormal_gallbladder_physiolo2.56021276
18MP0005671_abnormal_response_to2.55570168
19MP0003866_abnormal_defecation2.55361101
20MP0000566_synostosis2.41804503
21MP0003252_abnormal_bile_duct2.38433803
22MP0001188_hyperpigmentation2.37146079
23MP0005409_darkened_coat_color2.36196911
24MP0005083_abnormal_biliary_tract2.32942464
25MP0001873_stomach_inflammation2.28342023
26MP0000490_abnormal_crypts_of2.22396992
27MP0001790_abnormal_immune_system2.11113673
28MP0005387_immune_system_phenotype2.11113673
29MP0005365_abnormal_bile_salt2.02934793
30MP0001502_abnormal_circadian_rhythm1.99456671
31MP0005381_digestive/alimentary_phenotyp1.93720258
32MP0001968_abnormal_touch/_nociception1.92981905
33MP0008875_abnormal_xenobiotic_pharmacok1.92751551
34MP0005451_abnormal_body_composition1.91934983
35MP0000015_abnormal_ear_pigmentation1.91763283
36MP0001800_abnormal_humoral_immune1.91229051
37MP0000751_myopathy1.90993525
38MP0002139_abnormal_hepatobiliary_system1.90385563
39MP0010678_abnormal_skin_adnexa1.87498602
40MP0000750_abnormal_muscle_regeneration1.86068071
41MP0001929_abnormal_gametogenesis1.84985945
42MP0000477_abnormal_intestine_morphology1.83191355
43MP0002653_abnormal_ependyma_morphology1.81666165
44MP0001756_abnormal_urination1.80643889
45MP0003303_peritoneal_inflammation1.79837129
46MP0002638_abnormal_pupillary_reflex1.79780133
47MP0003111_abnormal_nucleus_morphology1.79295055
48MP0001661_extended_life_span1.76738618
49MP0003698_abnormal_male_reproductive1.75883860
50MP0001663_abnormal_digestive_system1.71576398
51MP0001835_abnormal_antigen_presentation1.67046945
52MP0010155_abnormal_intestine_physiology1.64568032
53MP0001849_ear_inflammation1.59465306
54MP0005330_cardiomyopathy1.58151866
55MP0003868_abnormal_feces_composition1.57954442
56MP0004381_abnormal_hair_follicle1.53239822
57MP0001664_abnormal_digestion1.50209256
58MP0000537_abnormal_urethra_morphology1.50039915
59MP0001348_abnormal_lacrimal_gland1.46035113
60MP0009046_muscle_twitch1.40781569
61MP0002723_abnormal_immune_serum1.39290198
62MP0002452_abnormal_antigen_presenting1.37902294
63MP0005000_abnormal_immune_tolerance1.35561974
64MP0000383_abnormal_hair_follicle1.31699671
65MP0004019_abnormal_vitamin_homeostasis1.30982161
66MP0003183_abnormal_peptide_metabolism1.30063460
67MP0005310_abnormal_salivary_gland1.29489098
68MP0003806_abnormal_nucleotide_metabolis1.28515054
69MP0000747_muscle_weakness1.23777975
70MP0003763_abnormal_thymus_physiology1.23367939
71MP0000569_abnormal_digit_pigmentation1.22533943
72MP0005584_abnormal_enzyme/coenzyme_acti1.22116797
73MP0002736_abnormal_nociception_after1.22008279
74MP0005332_abnormal_amino_acid1.20092609
75MP0002735_abnormal_chemical_nociception1.19489996
76MP0002254_reproductive_system_inflammat1.18730214
77MP0002148_abnormal_hypersensitivity_rea1.18534419
78MP0002876_abnormal_thyroid_physiology1.18224617
79MP0010329_abnormal_lipoprotein_level1.15988026
80MP0000013_abnormal_adipose_tissue1.15597718
81MP0005174_abnormal_tail_pigmentation1.15259484
82MP0003077_abnormal_cell_cycle1.13974871
83MP0002398_abnormal_bone_marrow1.13957393
84MP0000538_abnormal_urinary_bladder1.13785531
85MP0000579_abnormal_nail_morphology1.12367524
86MP0008877_abnormal_DNA_methylation1.11348165
87MP0010307_abnormal_tumor_latency1.10850512
88MP0005025_abnormal_response_to1.09001099
89MP0002420_abnormal_adaptive_immunity1.08649840
90MP0010352_gastrointestinal_tract_polyps1.07981245
91MP0002160_abnormal_reproductive_system1.07141012
92MP0004185_abnormal_adipocyte_glucose1.06001543
93MP0002210_abnormal_sex_determination1.05421131
94MP0002138_abnormal_hepatobiliary_system1.04885607
95MP0001819_abnormal_immune_cell1.04676652
96MP0003705_abnormal_hypodermis_morpholog1.03628326
97MP0001216_abnormal_epidermal_layer1.03468891
98MP0010094_abnormal_chromosome_stability1.03097121
99MP0000467_abnormal_esophagus_morphology1.02543422
100MP0009053_abnormal_anal_canal1.01814322
101MP0000716_abnormal_immune_system1.00281299
102MP0002136_abnormal_kidney_physiology0.99522852
103MP0003693_abnormal_embryo_hatching0.99478442
104MP0004043_abnormal_pH_regulation0.98525091
105MP0002161_abnormal_fertility/fecundity0.98221184
106MP0002098_abnormal_vibrissa_morphology0.97782978
107MP0000377_abnormal_hair_follicle0.97779546
108MP0002019_abnormal_tumor_incidence0.96592846
109MP0002060_abnormal_skin_morphology0.96490173
110MP0003938_abnormal_ear_development0.96018207
111MP0002429_abnormal_blood_cell0.95443345
112MP0002796_impaired_skin_barrier0.94626481
113MP0008995_early_reproductive_senescence0.94572057
114MP0001881_abnormal_mammary_gland0.94571707
115MP0005623_abnormal_meninges_morphology0.94308346
116MP0002277_abnormal_respiratory_mucosa0.94221213
117MP0002822_catalepsy0.93031190
118MP0000689_abnormal_spleen_morphology0.92346072
119MP0001145_abnormal_male_reproductive0.92163423
120MP0004947_skin_inflammation0.89838708
121MP0000003_abnormal_adipose_tissue0.89580629
122MP0003300_gastrointestinal_ulcer0.89114395
123MP0000653_abnormal_sex_gland0.88885536
124MP0004957_abnormal_blastocyst_morpholog0.87432111
125MP0002928_abnormal_bile_duct0.85579316
126MP0003453_abnormal_keratinocyte_physiol0.84898033
127MP0001845_abnormal_inflammatory_respons0.83491723
128MP0000358_abnormal_cell_content/0.81797071
129MP0002722_abnormal_immune_system0.81644570
130MP0004885_abnormal_endolymph0.80589584
131MP0003315_abnormal_perineum_morphology0.77907694
132MP0000627_abnormal_mammary_gland0.75925442
133MP0005666_abnormal_adipose_tissue0.75917255
134MP0001984_abnormal_olfaction0.75752459
135MP0005448_abnormal_energy_balance0.75671404
136MP0003718_maternal_effect0.75079651
137MP0001765_abnormal_ion_homeostasis0.74253936
138MP0001919_abnormal_reproductive_system0.73214022
139MP0005076_abnormal_cell_differentiation0.72583205
140MP0003890_abnormal_embryonic-extraembry0.72160107
141MP0003879_abnormal_hair_cell0.70943643
142MP0005670_abnormal_white_adipose0.70804252
143MP0003448_altered_tumor_morphology0.70498270
144MP0000367_abnormal_coat/_hair0.69668397
145MP0003937_abnormal_limbs/digits/tail_de0.69420795
146MP0000427_abnormal_hair_cycle0.69225619
147MP0002933_joint_inflammation0.69075164
148MP0005220_abnormal_exocrine_pancreas0.68798424
149MP0003045_fibrosis0.67325831
150MP0000470_abnormal_stomach_morphology0.66532473
151MP0005636_abnormal_mineral_homeostasis0.66247937
152MP0001905_abnormal_dopamine_level0.65539901
153MP0005084_abnormal_gallbladder_morpholo0.61387797
154MP0003941_abnormal_skin_development0.61105544
155MP0008057_abnormal_DNA_replication0.60937639
156MP0008004_abnormal_stomach_pH0.60058926
157MP0003436_decreased_susceptibility_to0.59902763
158MP0009785_altered_susceptibility_to0.59724241
159MP0004130_abnormal_muscle_cell0.59184183
160MP0009697_abnormal_copulation0.59168939
161MP0003091_abnormal_cell_migration0.58826006
162MP0010386_abnormal_urinary_bladder0.58664726
163MP0001958_emphysema0.58105863
164MP0005551_abnormal_eye_electrophysiolog0.57800752
165MP0008469_abnormal_protein_level0.57025320
166MP0000609_abnormal_liver_physiology0.56143446
167MP0009643_abnormal_urine_homeostasis0.56003041
168MP0005248_abnormal_Harderian_gland0.54444919
169MP0002166_altered_tumor_susceptibility0.54160825
170MP0009931_abnormal_skin_appearance0.53980659
171MP0000613_abnormal_salivary_gland0.53842870
172MP0002118_abnormal_lipid_homeostasis0.53636770
173MP0009115_abnormal_fat_cell0.53614871
174MP0008058_abnormal_DNA_repair0.53593515
175MP0001727_abnormal_embryo_implantation0.53360792
176MP0009333_abnormal_splenocyte_physiolog0.53193997
177MP0003936_abnormal_reproductive_system0.52505699
178MP0005501_abnormal_skin_physiology0.52362309
179MP0003699_abnormal_female_reproductive0.52036697
180MP0005058_abnormal_lysosome_morphology0.51609098

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.14118807
2Testicular atrophy (HP:0000029)5.64450478
3Squamous cell carcinoma (HP:0002860)5.29373686
4Gastrointestinal stroma tumor (HP:0100723)5.26150440
5Dynein arm defect of respiratory motile cilia (HP:0012255)5.16910706
6Absent/shortened dynein arms (HP:0200106)5.16910706
7Ileus (HP:0002595)5.12916145
8Rib fusion (HP:0000902)5.05504558
9Poikiloderma (HP:0001029)4.90356473
10Abnormal respiratory motile cilium physiology (HP:0012261)4.83068005
11Rectal fistula (HP:0100590)4.54301248
12Rectovaginal fistula (HP:0000143)4.54301248
13Vaginal fistula (HP:0004320)4.39050710
14Intestinal fistula (HP:0100819)4.29485623
15Dyschromatopsia (HP:0007641)4.22786003
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.19728080
17Recurrent sinusitis (HP:0011108)4.19707991
18Attenuation of retinal blood vessels (HP:0007843)4.10666753
19Chronic bronchitis (HP:0004469)4.10254311
20Prostate neoplasm (HP:0100787)3.94027592
21Male infertility (HP:0003251)3.91386701
22Emphysema (HP:0002097)3.86657665
23Rhinitis (HP:0012384)3.86546071
24Facial hemangioma (HP:0000329)3.74444921
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.73679956
26Right ventricular cardiomyopathy (HP:0011663)3.73505796
27Abnormal respiratory motile cilium morphology (HP:0005938)3.72223051
28Abnormal respiratory epithelium morphology (HP:0012253)3.72223051
29Akinesia (HP:0002304)3.71696862
30Abnormality of the intrinsic pathway (HP:0010989)3.69730975
31Hemorrhage of the eye (HP:0011885)3.69550240
32Recurrent bronchitis (HP:0002837)3.68468786
33Basal cell carcinoma (HP:0002671)3.63701136
34Popliteal pterygium (HP:0009756)3.63562784
35Abnormal ciliary motility (HP:0012262)3.56421768
36Ulnar bowing (HP:0003031)3.54859823
37Annular pancreas (HP:0001734)3.51722264
38Autoimmune thrombocytopenia (HP:0001973)3.44818803
39Thin bony cortex (HP:0002753)3.44489469
40Abnormality of small intestinal villus morphology (HP:0011472)3.44297698
41Villous atrophy (HP:0011473)3.44297698
42Fetal akinesia sequence (HP:0001989)3.43445893
43Progressive hearing impairment (HP:0001730)3.40528451
44Sensorimotor neuropathy (HP:0007141)3.40469479
45IgA deficiency (HP:0002720)3.40394518
46Acanthocytosis (HP:0001927)3.36506127
47Malnutrition (HP:0004395)3.34897419
48Joint hemorrhage (HP:0005261)3.32409388
49Lipid accumulation in hepatocytes (HP:0006561)3.23439329
50Congenital stationary night blindness (HP:0007642)3.21412056
51Aplasia of the musculature (HP:0100854)3.16857768
52Hypoalbuminemia (HP:0003073)3.14481415
53Abnormal albumin level (HP:0012116)3.14481415
54Lip pit (HP:0100267)3.13544891
55Facial diplegia (HP:0001349)3.13222893
56Abnormality of glutamine family amino acid metabolism (HP:0010902)3.11682547
57Mesangial abnormality (HP:0001966)3.11231535
58Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09702585
59Conjugated hyperbilirubinemia (HP:0002908)3.07524983
60Anteriorly placed anus (HP:0001545)3.05296282
61Renal Fanconi syndrome (HP:0001994)3.02933580
62Increased hepatocellular lipid droplets (HP:0006565)3.02488059
63Pili torti (HP:0003777)3.02188418
64Prolonged partial thromboplastin time (HP:0003645)2.99468732
65Turricephaly (HP:0000262)2.95618798
66Urethral obstruction (HP:0000796)2.95590590
67Chromsome breakage (HP:0040012)2.94146450
68Abnormality of chloride homeostasis (HP:0011422)2.92902583
69Flat acetabular roof (HP:0003180)2.90552048
70Chronic diarrhea (HP:0002028)2.90095420
71Pustule (HP:0200039)2.86953078
72Infertility (HP:0000789)2.86352090
73Cone-rod dystrophy (HP:0000548)2.85658472
74Milia (HP:0001056)2.84946274
75Premature graying of hair (HP:0002216)2.84680326
76Abnormality of placental membranes (HP:0011409)2.83717040
77Amniotic constriction ring (HP:0009775)2.83717040
78Bronchiectasis (HP:0002110)2.81140048
79Coronal craniosynostosis (HP:0004440)2.80940438
80Delayed epiphyseal ossification (HP:0002663)2.71039134
81Cupped ribs (HP:0000887)2.70096653
82Bony spicule pigmentary retinopathy (HP:0007737)2.69308241
83Patellar aplasia (HP:0006443)2.69058569
84Papillary thyroid carcinoma (HP:0002895)2.68265145
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67183187
86Curly hair (HP:0002212)2.67130151
87IgM deficiency (HP:0002850)2.62978397
88Ureteral obstruction (HP:0006000)2.61065543
89Ureteral stenosis (HP:0000071)2.60940480
90Lymphopenia (HP:0001888)2.60791175
91Chorioretinal atrophy (HP:0000533)2.60157078
92Agammaglobulinemia (HP:0004432)2.58872593
93Dry hair (HP:0011359)2.57505033
94Progressive sensorineural hearing impairment (HP:0000408)2.56283067
95Birth length less than 3rd percentile (HP:0003561)2.55000030
96Abnormality of the 1st metacarpal (HP:0010009)2.53747854
97Atrioventricular block (HP:0001678)2.52591402
98Alopecia of scalp (HP:0002293)2.52071426
99Ectopic kidney (HP:0000086)2.50434786
100Myotonia (HP:0002486)2.50248935
101Abdominal distention (HP:0003270)2.50097289
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.49316135
103Increased muscle lipid content (HP:0009058)2.47543751
104Aplasia/Hypoplasia of the patella (HP:0006498)2.45850891
105Short chin (HP:0000331)2.45574735
106Choroideremia (HP:0001139)2.42662975
107Abnormality of the preputium (HP:0100587)2.42174428
108Nasal polyposis (HP:0100582)2.40810785
109Azoospermia (HP:0000027)2.39963368
110Metabolic alkalosis (HP:0200114)2.39939099
111Increased intramyocellular lipid droplets (HP:0012240)2.38495885
112Sparse lateral eyebrow (HP:0005338)2.34034019
113Abnormal tarsal ossification (HP:0008369)2.32757789
114Hyperactive renin-angiotensin system (HP:0000841)2.32687688
115Impulsivity (HP:0100710)2.31411009
116Anal stenosis (HP:0002025)2.30171172
117Sensory axonal neuropathy (HP:0003390)2.30169863
118Abnormality of the fingertips (HP:0001211)2.29517556
119Restrictive lung disease (HP:0002091)2.28544261
120Neonatal onset (HP:0003623)2.25955622
121Pigmentary retinal degeneration (HP:0001146)2.23564988
122Vasculitis (HP:0002633)2.22991086
123Reduced antithrombin III activity (HP:0001976)2.21153522
124Recurrent pneumonia (HP:0006532)2.20663779
125Abnormality of the distal phalanx of the thumb (HP:0009617)2.18949191
126Hypoplasia of dental enamel (HP:0006297)2.18762093
127Abnormality of the carotid arteries (HP:0005344)2.18481332
128Hypoplasia of the pons (HP:0012110)2.18424264
129Joint stiffness (HP:0001387)2.17697427
130Short phalanx of the thumb (HP:0009660)2.16475851
131Hydroxyprolinuria (HP:0003080)2.15754554
132Abnormality of proline metabolism (HP:0010907)2.15754554
133Abnormal hair laboratory examination (HP:0003328)2.13090802
134Congenital sensorineural hearing impairment (HP:0008527)2.11639529
135Abnormal spermatogenesis (HP:0008669)2.11169421
136Meningitis (HP:0001287)2.11030389
137Onycholysis (HP:0001806)2.11023982
138Poikilocytosis (HP:0004447)2.10900043
139Flat occiput (HP:0005469)2.09569689
140Absent thumb (HP:0009777)2.08994139
141Capillary hemangiomas (HP:0005306)2.08914106
142Conical tooth (HP:0000698)2.06977877
143Recurrent otitis media (HP:0000403)2.06626968
144Abnormality of the costochondral junction (HP:0000919)2.06334233
145Decreased circulating renin level (HP:0003351)2.06328551
146Cheilitis (HP:0100825)2.06099443
147Abnormal epiphyseal ossification (HP:0010656)2.04480695
148Poor head control (HP:0002421)2.03402955
149Hypophosphatemic rickets (HP:0004912)2.02827437
150Ectropion (HP:0000656)2.00930447
151Leukopenia (HP:0001882)2.00917969
152Widely patent fontanelles and sutures (HP:0004492)2.00302060
153Fat malabsorption (HP:0002630)1.98943386
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96180092
155Abnormality of the pons (HP:0007361)1.95797459
156Enlarged epiphyses (HP:0010580)1.95204332
157Abnormal biliary tract morphology (HP:0012440)1.95080089
158Urticaria (HP:0001025)1.94472641
159Bronchitis (HP:0012387)1.93835231
160Spontaneous abortion (HP:0005268)1.93715564
161Abnormality of the gastric mucosa (HP:0004295)1.93711438
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.92679817
163Myopathic facies (HP:0002058)1.92578184
164Epiphyseal stippling (HP:0010655)1.92031049
165Zonular cataract (HP:0010920)1.90231455
166Breast hypoplasia (HP:0003187)1.88909934
167Abnormality of chromosome stability (HP:0003220)1.88474205
168Abnormality of the phalanges of the hallux (HP:0010057)1.88351578
169Abnormality of macular pigmentation (HP:0008002)1.87387114
170Lymphoma (HP:0002665)1.87178345
171Dehydration (HP:0001944)1.86718173
172Flattened epiphyses (HP:0003071)1.85373693
173Cellulitis (HP:0100658)1.84543578
174Hypobetalipoproteinemia (HP:0003563)1.84309105
175Facial shape deformation (HP:0011334)1.84221563
176Potter facies (HP:0002009)1.84221563
177Exertional dyspnea (HP:0002875)1.84127834
178Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83652505
179Abnormality of the renal medulla (HP:0100957)1.83456574
180IgG deficiency (HP:0004315)1.81550279
181Decreased central vision (HP:0007663)1.80348239
182Shawl scrotum (HP:0000049)1.80327516
183Renovascular hypertension (HP:0100817)1.80292916
184Fatigue (HP:0012378)1.80280477
185Abnormality of the renal cortex (HP:0011035)1.80203424
186Narrow nasal bridge (HP:0000446)1.77626469
187Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.77060240
188Short 1st metacarpal (HP:0010034)1.77060240
189Tubulointerstitial nephritis (HP:0001970)1.76595989
190Tubulointerstitial fibrosis (HP:0005576)1.74097031
191Nephronophthisis (HP:0000090)1.73434227
192Tubulointerstitial abnormality (HP:0001969)1.70643566
193Syncope (HP:0001279)1.70402243
194Abnormality of purine metabolism (HP:0004352)1.70336262
195Polycythemia (HP:0001901)1.68985090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.71810521
2VRK15.18180565
3MAPK155.13258770
4STK38L5.06761143
5FRK4.57487526
6BLK4.41475528
7LATS23.57001731
8PIK3CA3.06004462
9LMTK22.99576209
10DAPK32.96639371
11STK32.68250269
12RPS6KA52.55365312
13AKT32.31657444
14STK382.28628757
15SMG12.18931501
16AURKA2.14338199
17TESK12.08538683
18CDK122.07592896
19TAOK12.05629174
20TESK21.96634457
21PDK41.96555316
22PDK31.96555316
23ERBB41.95184518
24CAMK1D1.91998401
25TTK1.87172085
26BCKDK1.84035713
27ERN11.83153709
28RIPK11.75935155
29NUAK11.65016880
30MST1R1.64248093
31MAP3K91.58005363
32MAP4K11.55405192
33TBK11.50966636
34TAOK31.46640928
35PRKG21.37947539
36EPHB21.37696827
37EIF2AK11.31982976
38MST41.30256841
39PRKD31.29919511
40PDK21.29887748
41STK161.29223610
42MAP2K21.26914673
43SIK21.25817924
44MUSK1.21423541
45IRAK41.20961974
46CAMK1G1.20237101
47PDGFRB1.18791640
48ARAF1.18257138
49NEK91.14856238
50IKBKE1.07233071
51SYK1.06688833
52NEK21.06561424
53CCNB11.05910630
54CHEK21.04039638
55PIM21.03764389
56STK41.02934068
57ICK1.01638837
58ABL20.98397710
59IKBKB0.97902402
60MAP2K60.97581347
61EPHA20.95809368
62PKN10.92691036
63TAF10.91103460
64VRK20.90818595
65EEF2K0.84435919
66PRKCI0.84151836
67DDR20.84082098
68PRKAA20.82751435
69NME10.82661815
70PRKAA10.82595395
71MAP3K60.80768059
72MAPK120.80623136
73PTK60.74999597
74ADRBK20.74658152
75SIK10.71919339
76MAP3K20.71746499
77PTK20.71542915
78LYN0.70578077
79CSK0.69765264
80PRKCQ0.68176750
81MAPKAPK30.66272797
82AURKB0.65791320
83MELK0.62435948
84GRK60.62306985
85HIPK20.58367719
86ABL10.57702255
87CDC70.55528347
88STK240.54033966
89ERBB20.53357895
90BTK0.51732329
91GRK10.51102068
92WNK10.50302385
93ATM0.50051721
94CDK150.49774544
95DYRK1B0.48719845
96MAPKAPK50.48134287
97ADRBK10.45954874
98STK100.43709627
99CDK180.43477546
100CDK40.43316831
101CDK11A0.43126303
102RIPK40.42826116
103CDK90.40865538
104PRKCD0.38723504
105ACVR1B0.38333021
106PRKD10.37291814
107PRKD20.35951720
108CHUK0.35069738
109PDPK10.34498955
110MAPK70.34287666
111JAK30.33996164
112KSR20.33512991
113CDK80.32331585
114PDK10.32070166
115CHEK10.31464500
116MAP3K30.31319659
117YES10.31027296
118TNK20.30696987
119FGFR40.29272243
120CSF1R0.28935560
121MTOR0.28318588
122MAP3K140.28207694
123MAP3K130.28029051
124DMPK0.27472366
125MET0.27337961
126TRIB30.27258603
127MAP2K30.27185122
128CAMK2D0.27040115
129RPS6KA20.26495183
130MAP3K70.26225660
131PLK40.25090885
132MARK20.24534261
133SGK10.24284264
134MAPK110.24085866
135MAP3K100.23954482
136CDK140.23283521
137AKT20.22871704
138STK110.22787564
139MAP3K80.22753616
140PIM10.22706328
141ZAK0.22163225
142MYLK0.21710326
143SGK30.20733958
144STK390.20670975
145BRAF0.20348648
146PTK2B0.20063402
147RPS6KA60.18241543
148PLK10.17929983
149DYRK20.17585119
150PAK20.17487185
151FER0.17135574
152KSR10.17127923
153ATR0.16709512
154WNK40.16527492
155OXSR10.16478037
156EPHB10.16081339
157MAPK100.15800059
158NLK0.15674693
159BUB10.15321869
160MAPK80.15195871
161PAK10.15124329
162TLK10.14699071
163SGK20.14365904
164GRK50.14253501
165ZAP700.13688375
166JAK20.13247474
167RPS6KC10.13164104
168RPS6KL10.13164104
169RPS6KB20.12970730
170PRKCH0.11865583
171ROCK10.11725476

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053228.94552734
2Alcoholism_Homo sapiens_hsa050346.00472001
3Fat digestion and absorption_Homo sapiens_hsa049754.18641090
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.05267765
5Sulfur metabolism_Homo sapiens_hsa009204.04392674
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.95887241
7Mineral absorption_Homo sapiens_hsa049783.76839535
8Vitamin digestion and absorption_Homo sapiens_hsa049772.99637968
9Allograft rejection_Homo sapiens_hsa053302.68986643
10Pentose phosphate pathway_Homo sapiens_hsa000302.62890843
11Renin-angiotensin system_Homo sapiens_hsa046142.62081468
12Asthma_Homo sapiens_hsa053102.54540928
13Caffeine metabolism_Homo sapiens_hsa002322.50583122
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.48972020
15Autoimmune thyroid disease_Homo sapiens_hsa053202.48270613
16Bile secretion_Homo sapiens_hsa049762.37631411
17Primary immunodeficiency_Homo sapiens_hsa053402.35101946
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32091906
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.28106987
20Viral carcinogenesis_Homo sapiens_hsa052032.21915803
21Graft-versus-host disease_Homo sapiens_hsa053322.16937236
22Carbohydrate digestion and absorption_Homo sapiens_hsa049732.16762427
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11627196
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.98911402
25Linoleic acid metabolism_Homo sapiens_hsa005911.94439313
26Type I diabetes mellitus_Homo sapiens_hsa049401.86955198
27Galactose metabolism_Homo sapiens_hsa000521.82112026
28Sphingolipid metabolism_Homo sapiens_hsa006001.67940782
29Viral myocarditis_Homo sapiens_hsa054161.66346514
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57475415
31Histidine metabolism_Homo sapiens_hsa003401.51933640
32Protein digestion and absorption_Homo sapiens_hsa049741.48018868
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47791915
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.47613328
35Fructose and mannose metabolism_Homo sapiens_hsa000511.46591974
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43646516
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43093070
38Glycerolipid metabolism_Homo sapiens_hsa005611.42250704
39Starch and sucrose metabolism_Homo sapiens_hsa005001.42244336
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40508230
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40487470
42PPAR signaling pathway_Homo sapiens_hsa033201.39194897
43Fatty acid biosynthesis_Homo sapiens_hsa000611.30734827
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29691115
45ABC transporters_Homo sapiens_hsa020101.25940934
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24822422
47Glutathione metabolism_Homo sapiens_hsa004801.21855286
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21324873
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19586308
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.18635146
51Leishmaniasis_Homo sapiens_hsa051401.16034698
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.15046704
53Staphylococcus aureus infection_Homo sapiens_hsa051501.12436669
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10039457
55Lysine degradation_Homo sapiens_hsa003101.09098946
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.06899227
57Antigen processing and presentation_Homo sapiens_hsa046121.06184104
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05866593
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03483722
60B cell receptor signaling pathway_Homo sapiens_hsa046620.98212362
61Chemical carcinogenesis_Homo sapiens_hsa052040.97726741
62Arachidonic acid metabolism_Homo sapiens_hsa005900.94075762
63Tight junction_Homo sapiens_hsa045300.92417869
64Selenocompound metabolism_Homo sapiens_hsa004500.91159146
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90916779
66Retinol metabolism_Homo sapiens_hsa008300.86593456
67Fanconi anemia pathway_Homo sapiens_hsa034600.83733665
68Ether lipid metabolism_Homo sapiens_hsa005650.80076151
69Thyroid hormone synthesis_Homo sapiens_hsa049180.79373573
70Fatty acid degradation_Homo sapiens_hsa000710.77195839
71Dorso-ventral axis formation_Homo sapiens_hsa043200.72616449
72Tryptophan metabolism_Homo sapiens_hsa003800.71160109
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69924371
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.69674631
75Hematopoietic cell lineage_Homo sapiens_hsa046400.68447431
76p53 signaling pathway_Homo sapiens_hsa041150.68076240
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67698147
78Adherens junction_Homo sapiens_hsa045200.67512032
79Pancreatic secretion_Homo sapiens_hsa049720.67223460
80Hedgehog signaling pathway_Homo sapiens_hsa043400.65427731
81Herpes simplex infection_Homo sapiens_hsa051680.64107890
82Influenza A_Homo sapiens_hsa051640.62962917
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62624452
84Hepatitis C_Homo sapiens_hsa051600.61945651
85Folate biosynthesis_Homo sapiens_hsa007900.61371712
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60177064
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56800583
88Epstein-Barr virus infection_Homo sapiens_hsa051690.56205081
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55553876
90Salivary secretion_Homo sapiens_hsa049700.54909347
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53400501
92Arginine and proline metabolism_Homo sapiens_hsa003300.51756479
93Ovarian steroidogenesis_Homo sapiens_hsa049130.51589724
94Pyruvate metabolism_Homo sapiens_hsa006200.51543244
95Rheumatoid arthritis_Homo sapiens_hsa053230.50806378
96Inositol phosphate metabolism_Homo sapiens_hsa005620.50175542
97Vitamin B6 metabolism_Homo sapiens_hsa007500.49057706
98Tuberculosis_Homo sapiens_hsa051520.46044590
99beta-Alanine metabolism_Homo sapiens_hsa004100.44622894
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43490853
101Phenylalanine metabolism_Homo sapiens_hsa003600.43470763
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.43154718
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43132165
104Choline metabolism in cancer_Homo sapiens_hsa052310.43012407
105Salmonella infection_Homo sapiens_hsa051320.42533222
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41904552
107Type II diabetes mellitus_Homo sapiens_hsa049300.41210169
108HTLV-I infection_Homo sapiens_hsa051660.41031936
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38927042
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37633988
111Circadian rhythm_Homo sapiens_hsa047100.37172731
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36666564
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.36485626
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.36334165
115Toxoplasmosis_Homo sapiens_hsa051450.36148114
116Prolactin signaling pathway_Homo sapiens_hsa049170.35039939
117Purine metabolism_Homo sapiens_hsa002300.34937405
118Lysosome_Homo sapiens_hsa041420.34115006
119Carbon metabolism_Homo sapiens_hsa012000.33746567
120Apoptosis_Homo sapiens_hsa042100.30745665
121Sulfur relay system_Homo sapiens_hsa041220.30502096
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30475114
123Arginine biosynthesis_Homo sapiens_hsa002200.30187910
124Biosynthesis of amino acids_Homo sapiens_hsa012300.29487946
125Glucagon signaling pathway_Homo sapiens_hsa049220.29135850
126Homologous recombination_Homo sapiens_hsa034400.28860221
127Base excision repair_Homo sapiens_hsa034100.28753044
128Tyrosine metabolism_Homo sapiens_hsa003500.28489246
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28356505
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.27301138
131TNF signaling pathway_Homo sapiens_hsa046680.27212231
132Butanoate metabolism_Homo sapiens_hsa006500.27185981
133Small cell lung cancer_Homo sapiens_hsa052220.27140342
134Other glycan degradation_Homo sapiens_hsa005110.26369637
135Gastric acid secretion_Homo sapiens_hsa049710.25480625
136Thyroid cancer_Homo sapiens_hsa052160.24075118
137Taste transduction_Homo sapiens_hsa047420.22958077
138Metabolic pathways_Homo sapiens_hsa011000.21369609
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.21363378
140MicroRNAs in cancer_Homo sapiens_hsa052060.21151218
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21133527
142Hippo signaling pathway_Homo sapiens_hsa043900.21103816
143Phagosome_Homo sapiens_hsa041450.19663742
144Insulin resistance_Homo sapiens_hsa049310.19207013
145Pancreatic cancer_Homo sapiens_hsa052120.19079835
146Measles_Homo sapiens_hsa051620.18814385
147Basal cell carcinoma_Homo sapiens_hsa052170.18438303
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16344611
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16118187
150ErbB signaling pathway_Homo sapiens_hsa040120.15957627
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15689201
152Fatty acid metabolism_Homo sapiens_hsa012120.15236720
153Insulin secretion_Homo sapiens_hsa049110.15234018
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12610566
155Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12271448
156DNA replication_Homo sapiens_hsa030300.09797934
157Bladder cancer_Homo sapiens_hsa052190.07936915
158N-Glycan biosynthesis_Homo sapiens_hsa005100.05425554
159Calcium signaling pathway_Homo sapiens_hsa040200.03244012
160Pyrimidine metabolism_Homo sapiens_hsa002400.03092779
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.02728877
162Melanogenesis_Homo sapiens_hsa049160.00376533
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.00050575
164Hepatitis B_Homo sapiens_hsa051610.00029207
165Chemokine signaling pathway_Homo sapiens_hsa04062-0.0262058
166Huntingtons disease_Homo sapiens_hsa05016-0.0234363
167Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0196952

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