TMC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.27033504
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.27033504
3positive regulation of gamma-delta T cell activation (GO:0046645)5.90230551
4antigen processing and presentation of endogenous antigen (GO:0019883)5.69640891
5regulation of gamma-delta T cell differentiation (GO:0045586)5.19994978
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.69078946
7regulation of gamma-delta T cell activation (GO:0046643)4.68507207
8positive thymic T cell selection (GO:0045059)4.48444575
9negative thymic T cell selection (GO:0045060)4.39234762
10negative T cell selection (GO:0043383)4.38588621
11ribosomal small subunit assembly (GO:0000028)4.33453864
12thymic T cell selection (GO:0045061)4.13172404
13positive regulation by symbiont of host defense response (GO:0052509)4.12368433
14modulation by symbiont of host defense response (GO:0052031)4.12368433
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12368433
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12368433
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.12368433
18modulation by symbiont of host immune response (GO:0052553)4.12368433
19detection of bacterium (GO:0016045)4.11178071
20detection of other organism (GO:0098543)4.00140824
21viral transcription (GO:0019083)3.82306306
22response to muramyl dipeptide (GO:0032495)3.76565475
23negative regulation of lymphocyte mediated immunity (GO:0002707)3.75027845
24T cell selection (GO:0045058)3.69366239
25immunoglobulin mediated immune response (GO:0016064)3.63822732
26translational termination (GO:0006415)3.61865575
27negative regulation of T cell mediated immunity (GO:0002710)3.58116419
28leukocyte aggregation (GO:0070486)3.53851768
29positive T cell selection (GO:0043368)3.51000022
30neutrophil activation involved in immune response (GO:0002283)3.48508784
31negative regulation of leukocyte mediated immunity (GO:0002704)3.46530735
32regulation of B cell receptor signaling pathway (GO:0050855)3.43175021
33interferon-gamma production (GO:0032609)3.42891393
34macrophage activation involved in immune response (GO:0002281)3.42123377
35response to interleukin-15 (GO:0070672)3.41591292
36positive regulation of B cell differentiation (GO:0045579)3.41520316
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.37985606
38negative regulation of erythrocyte differentiation (GO:0045647)3.30387403
39T cell migration (GO:0072678)3.28727739
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27789196
41negative regulation of cell killing (GO:0031342)3.27789196
42activated T cell proliferation (GO:0050798)3.27483081
43translational elongation (GO:0006414)3.24746272
44regulation of interferon-beta biosynthetic process (GO:0045357)3.23509834
45germinal center formation (GO:0002467)3.21881109
46regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.21788316
47regulation of natural killer cell mediated immunity (GO:0002715)3.21788316
48regulation of B cell differentiation (GO:0045577)3.20765015
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18290650
50antigen processing and presentation via MHC class Ib (GO:0002475)3.17139422
51regulation of T cell tolerance induction (GO:0002664)3.16662844
52T cell receptor signaling pathway (GO:0050852)3.16248424
53mannose metabolic process (GO:0006013)3.16135332
54response to peptidoglycan (GO:0032494)3.14798160
55NIK/NF-kappaB signaling (GO:0038061)3.12156619
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10780794
57regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09528446
58protein targeting to ER (GO:0045047)3.09075188
59ribosomal small subunit biogenesis (GO:0042274)3.07505528
60cotranslational protein targeting to membrane (GO:0006613)3.07009007
61negative regulation of innate immune response (GO:0045824)3.06706468
62regulation of interleukin-12 biosynthetic process (GO:0045075)3.06579793
63detection of external biotic stimulus (GO:0098581)3.04963578
64antigen receptor-mediated signaling pathway (GO:0050851)3.04422020
65B cell receptor signaling pathway (GO:0050853)3.03223174
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02764391
67respiratory burst (GO:0045730)3.02003632
68regulation of T cell mediated cytotoxicity (GO:0001914)3.00955889
69regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98665671
70regulation of alpha-beta T cell proliferation (GO:0046640)2.96773715
71T cell costimulation (GO:0031295)2.96126300
72interferon-gamma-mediated signaling pathway (GO:0060333)2.95754574
73regulation of granulocyte differentiation (GO:0030852)2.95464807
74defense response to protozoan (GO:0042832)2.95300676
75establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95168071
76myeloid cell activation involved in immune response (GO:0002275)2.95035766
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94822316
78regulation of mast cell degranulation (GO:0043304)2.94158622
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93372190
80B cell homeostasis (GO:0001782)2.91825255
81lymphocyte costimulation (GO:0031294)2.89293564
82regulation of T cell receptor signaling pathway (GO:0050856)2.88716456
83regulation of antigen processing and presentation (GO:0002577)2.88457693
84protein localization to endoplasmic reticulum (GO:0070972)2.87316028
85B cell mediated immunity (GO:0019724)2.87055921
86positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86684643
87T cell homeostasis (GO:0043029)2.86081690
88erythrocyte maturation (GO:0043249)2.84782057
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84591814
90regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.84440956
91regulation of response to interferon-gamma (GO:0060330)2.84423586
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84417205
93regulation of isotype switching to IgG isotypes (GO:0048302)2.83978841
94neutrophil activation (GO:0042119)2.83736290
95mast cell activation (GO:0045576)2.82879519
96viral life cycle (GO:0019058)2.81427527
97response to protozoan (GO:0001562)2.81410746
98leukocyte degranulation (GO:0043299)2.80877119
99positive regulation of antigen processing and presentation (GO:0002579)2.79144197
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.78745371
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.77918956
102cellular response to interleukin-15 (GO:0071350)2.77843845
103JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77181940
104positive regulation of Rap GTPase activity (GO:0032854)2.76721883
105cellular protein complex disassembly (GO:0043624)2.71226429
106translational initiation (GO:0006413)2.71076905
107positive regulation of interleukin-2 production (GO:0032743)2.70240642
108leukocyte cell-cell adhesion (GO:0007159)2.69971277
109response to type I interferon (GO:0034340)2.68812073
110negative regulation of phagocytosis (GO:0050765)2.67160090
111negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65109717
112regulation of regulatory T cell differentiation (GO:0045589)2.64880187
113tolerance induction (GO:0002507)2.63541072
114hepatocyte apoptotic process (GO:0097284)2.61813908
115lymphocyte homeostasis (GO:0002260)2.60453586
116type I interferon signaling pathway (GO:0060337)2.60446273
117cellular response to type I interferon (GO:0071357)2.60446273
118natural killer cell differentiation (GO:0001779)2.59557036
119positive regulation of tolerance induction (GO:0002645)2.56829794
120maturation of SSU-rRNA (GO:0030490)2.56637715
121positive regulation of isotype switching (GO:0045830)2.56564511
122regulation of interleukin-2 biosynthetic process (GO:0045076)2.56079627
123cellular response to interleukin-4 (GO:0071353)2.51960822
124negative regulation of interleukin-12 production (GO:0032695)2.47832489
125protein complex disassembly (GO:0043241)2.43694088
126positive regulation of lamellipodium assembly (GO:0010592)2.43223846
127angiogenesis involved in wound healing (GO:0060055)2.41213510
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40056296
129negative regulation of stress fiber assembly (GO:0051497)2.39334417
130regulation of tolerance induction (GO:0002643)2.37186193
131natural killer cell activation (GO:0030101)2.36559553
132regulation of necroptotic process (GO:0060544)2.34932483
133myeloid dendritic cell activation (GO:0001773)2.34869122
134protoporphyrinogen IX metabolic process (GO:0046501)2.34410189
135positive regulation of granulocyte differentiation (GO:0030854)2.34366636
136immune response-activating cell surface receptor signaling pathway (GO:0002429)2.32778405
137mucosal-associated lymphoid tissue development (GO:0048537)2.32623150
138Peyers patch development (GO:0048541)2.32623150
139positive regulation of histone deacetylation (GO:0031065)2.31287484
140cellular response to interferon-beta (GO:0035458)2.30971668
141response to interleukin-4 (GO:0070670)2.30005123
142cellular extravasation (GO:0045123)2.28675773
143formation of translation preinitiation complex (GO:0001731)2.27149359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.63252054
2MYC_22102868_ChIP-Seq_BL_Human3.22673860
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.10326637
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00273891
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95153937
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.94094134
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.73009710
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54338831
9* VDR_21846776_ChIP-Seq_THP-1_Human2.53509569
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50393609
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.43232717
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25344426
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21888650
14* MAF_26560356_Chip-Seq_TH1_Human2.17625760
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17590009
16* MYB_26560356_Chip-Seq_TH2_Human2.07764211
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.01324918
18SCL_19346495_ChIP-Seq_HPC-7_Human2.01185947
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97937059
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97362364
21UTX_26944678_Chip-Seq_JUKART_Human1.96812497
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96595396
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93145105
24MYB_26560356_Chip-Seq_TH1_Human1.90580896
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.87553658
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87167210
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84793198
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81451752
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.81132633
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79918351
31SPI1_23547873_ChIP-Seq_NB4_Human1.75028330
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71378278
33RUNX_20019798_ChIP-Seq_JUKART_Human1.70681155
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70185382
35* TCF7_22412390_ChIP-Seq_EML_Mouse1.69845678
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.68747999
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68308925
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66793996
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65177140
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64194139
41VDR_24763502_ChIP-Seq_THP-1_Human1.64011840
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59534863
43* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58621137
44CIITA_25753668_ChIP-Seq_RAJI_Human1.57417250
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.56658664
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.55221867
47MAF_26560356_Chip-Seq_TH2_Human1.55191846
48* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52576886
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48133550
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47295401
51* KDM2B_26808549_Chip-Seq_JURKAT_Human1.46661010
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45925916
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45588669
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44833663
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43677214
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.43020318
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.42130113
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40572458
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40108650
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38869301
61GATA1_22025678_ChIP-Seq_K562_Human1.36410918
62VDR_23849224_ChIP-Seq_CD4+_Human1.33320716
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33156893
64* KDM2B_26808549_Chip-Seq_DND41_Human1.32175255
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29487938
66BCL6_27268052_Chip-Seq_Bcells_Human1.29320801
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28908325
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28257880
69BCOR_27268052_Chip-Seq_Bcells_Human1.28154495
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26992049
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24419423
72FOXP3_21729870_ChIP-Seq_TREG_Human1.23223157
73* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21876455
74RACK7_27058665_Chip-Seq_MCF-7_Human1.21681865
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.20210219
76XRN2_22483619_ChIP-Seq_HELA_Human1.19911105
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19173697
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19035447
79P68_20966046_ChIP-Seq_HELA_Human1.18919161
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.18110500
81GATA3_27048872_Chip-Seq_THYMUS_Human1.15291952
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14377899
83* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14193852
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14097652
85* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12222405
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12123019
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.12027994
88SPI1_23127762_ChIP-Seq_K562_Human1.11763678
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10894568
90NCOR1_26117541_ChIP-Seq_K562_Human1.08008537
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.07294380
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05323809
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05309797
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04730941
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03795529
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.02575469
97GATA3_26560356_Chip-Seq_TH2_Human1.02046578
98* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01715534
99* LXR_22292898_ChIP-Seq_THP-1_Human1.01031432
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99867157
101KDM5A_27292631_Chip-Seq_BREAST_Human0.99181117
102* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98976567
103RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98304632
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97529935
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97100635
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97053046
107* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95895106
108SMC4_20622854_ChIP-Seq_HELA_Human0.95702199
109E2F1_21310950_ChIP-Seq_MCF-7_Human0.95602574
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95444839
111GATA1_19941826_ChIP-Seq_K562_Human0.94905745
112KDM2B_26808549_Chip-Seq_K562_Human0.94633136
113VDR_24787735_ChIP-Seq_THP-1_Human0.94372554
114JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94189435
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93294264
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93192077
117* GATA2_19941826_ChIP-Seq_K562_Human0.92371630
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92222032
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92193951
120* TFEB_21752829_ChIP-Seq_HELA_Human0.91950681
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91721656
122CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91583423
123GABP_19822575_ChIP-Seq_HepG2_Human0.90868250
124* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90523542
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90171329
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.90110894
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89743198
128DCP1A_22483619_ChIP-Seq_HELA_Human0.88800762
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86839264
130CTCF_26484167_Chip-Seq_Bcells_Mouse0.86763159
131ZNF263_19887448_ChIP-Seq_K562_Human0.86631206
132* PU_27001747_Chip-Seq_BMDM_Mouse0.86567777
133* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85831404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.48231049
2MP0000685_abnormal_immune_system3.03043551
3MP0001835_abnormal_antigen_presentation2.97769124
4MP0005671_abnormal_response_to2.90703265
5MP0002166_altered_tumor_susceptibility2.71567264
6MP0002396_abnormal_hematopoietic_system2.67381162
7MP0001800_abnormal_humoral_immune2.64307565
8MP0001790_abnormal_immune_system2.41164976
9MP0005387_immune_system_phenotype2.41164976
10MP0002398_abnormal_bone_marrow2.33897718
11MP0009333_abnormal_splenocyte_physiolog2.27723310
12MP0003436_decreased_susceptibility_to2.23118181
13MP0002452_abnormal_antigen_presenting2.22848005
14MP0002420_abnormal_adaptive_immunity2.21314353
15MP0001819_abnormal_immune_cell2.18281757
16MP0005000_abnormal_immune_tolerance2.16814798
17MP0002723_abnormal_immune_serum2.15806912
18MP0001873_stomach_inflammation2.13301299
19MP0003172_abnormal_lysosome_physiology2.08213075
20MP0002006_tumorigenesis2.05571436
21MP0000689_abnormal_spleen_morphology2.01877271
22MP0005025_abnormal_response_to2.01798817
23MP0002722_abnormal_immune_system2.01482831
24MP0000716_abnormal_immune_system1.98094445
25MP0003656_abnormal_erythrocyte_physiolo1.96504895
26MP0010155_abnormal_intestine_physiology1.94463753
27MP0004947_skin_inflammation1.93382237
28MP0009785_altered_susceptibility_to1.92703954
29MP0005397_hematopoietic_system_phenotyp1.90678572
30MP0001545_abnormal_hematopoietic_system1.90678572
31MP0002405_respiratory_system_inflammati1.89140992
32MP0010352_gastrointestinal_tract_polyps1.87719876
33MP0003300_gastrointestinal_ulcer1.86202114
34MP0005464_abnormal_platelet_physiology1.80853446
35MP0000703_abnormal_thymus_morphology1.80743917
36MP0003866_abnormal_defecation1.80435167
37MP0000490_abnormal_crypts_of1.79833495
38MP0002429_abnormal_blood_cell1.79618032
39MP0004808_abnormal_hematopoietic_stem1.78635275
40MP0005451_abnormal_body_composition1.76110959
41MP0008260_abnormal_autophagy1.64683966
42MP0002419_abnormal_innate_immunity1.64177502
43MP0003303_peritoneal_inflammation1.61319278
44MP0003693_abnormal_embryo_hatching1.60573876
45MP0003724_increased_susceptibility_to1.55097239
46MP0002148_abnormal_hypersensitivity_rea1.50614168
47MP0001845_abnormal_inflammatory_respons1.50187545
48MP0000465_gastrointestinal_hemorrhage1.46063221
49MP0001853_heart_inflammation1.40371749
50MP0006082_CNS_inflammation1.35300529
51MP0010234_abnormal_vibrissa_follicle1.34666240
52MP0000858_altered_metastatic_potential1.33489325
53MP0003077_abnormal_cell_cycle1.30369927
54MP0009278_abnormal_bone_marrow1.29685306
55MP0004957_abnormal_blastocyst_morpholog1.29039191
56MP0002933_joint_inflammation1.27858083
57MP0006054_spinal_hemorrhage1.24503750
58MP0002019_abnormal_tumor_incidence1.23848590
59MP0005023_abnormal_wound_healing1.21354189
60MP0003111_abnormal_nucleus_morphology1.19118994
61MP0003191_abnormal_cellular_cholesterol1.18751332
62MP0010094_abnormal_chromosome_stability1.17503980
63MP0002132_abnormal_respiratory_system1.16652410
64MP0002998_abnormal_bone_remodeling1.15653023
65MP0003566_abnormal_cell_adhesion1.14176863
66MP0008057_abnormal_DNA_replication1.10403526
67MP0008469_abnormal_protein_level1.09136257
68MP0005075_abnormal_melanosome_morpholog1.08635391
69MP0003183_abnormal_peptide_metabolism1.06401751
70MP0001533_abnormal_skeleton_physiology1.05534791
71MP0004147_increased_porphyrin_level1.04629089
72MP0003453_abnormal_keratinocyte_physiol1.01722367
73MP0003828_pulmonary_edema1.01713291
74MP0005310_abnormal_salivary_gland0.95713698
75MP0009840_abnormal_foam_cell0.94981666
76MP0005501_abnormal_skin_physiology0.91748100
77MP0004381_abnormal_hair_follicle0.90844625
78MP0003448_altered_tumor_morphology0.89159167
79MP0002009_preneoplasia0.88972805
80MP0000477_abnormal_intestine_morphology0.88582081
81MP0001216_abnormal_epidermal_layer0.85580475
82MP0003705_abnormal_hypodermis_morpholog0.85129448
83MP0004883_abnormal_blood_vessel0.82492924
84MP0002796_impaired_skin_barrier0.82469571
85MP0002136_abnormal_kidney_physiology0.81572612
86MP0003690_abnormal_glial_cell0.81028804
87MP0005076_abnormal_cell_differentiation0.78717915
88MP0009764_decreased_sensitivity_to0.78354953
89MP0009931_abnormal_skin_appearance0.78169053
90MP0005174_abnormal_tail_pigmentation0.77791647
91MP0000604_amyloidosis0.77242866
92MP0000609_abnormal_liver_physiology0.76005542
93MP0000313_abnormal_cell_death0.74632829
94MP0000350_abnormal_cell_proliferation0.74629853
95MP0003045_fibrosis0.74563937
96MP0001243_abnormal_dermal_layer0.74484527
97MP0008007_abnormal_cellular_replicative0.74065862
98MP0009643_abnormal_urine_homeostasis0.72388329
99MP0001986_abnormal_taste_sensitivity0.72005459
100MP0001348_abnormal_lacrimal_gland0.71456424
101MP0002138_abnormal_hepatobiliary_system0.71230484
102MP0005166_decreased_susceptibility_to0.70220282
103MP0010307_abnormal_tumor_latency0.70064364
104MP0005058_abnormal_lysosome_morphology0.69505835
105MP0004510_myositis0.68892664
106MP0001663_abnormal_digestive_system0.68270183
107MP0001191_abnormal_skin_condition0.67730344
108MP0002060_abnormal_skin_morphology0.67099345
109MP0001730_embryonic_growth_arrest0.66994893
110MP0000249_abnormal_blood_vessel0.66969040
111MP0004185_abnormal_adipocyte_glucose0.65866924
112MP0001851_eye_inflammation0.65225889
113MP0000015_abnormal_ear_pigmentation0.65222899
114MP0002877_abnormal_melanocyte_morpholog0.65148585
115MP0000598_abnormal_liver_morphology0.65146013
116MP0002254_reproductive_system_inflammat0.64333036
117MP0004264_abnormal_extraembryonic_tissu0.62462371
118MP0009763_increased_sensitivity_to0.62206037
119MP0003075_altered_response_to0.61258143
120MP0003091_abnormal_cell_migration0.59565479
121MP0003795_abnormal_bone_structure0.59511235
122MP0008961_abnormal_basal_metabolism0.58904538
123MP0005390_skeleton_phenotype0.57543821
124MP0002693_abnormal_pancreas_physiology0.54560613
125MP0008874_decreased_physiological_sensi0.53898014
126MP0005083_abnormal_biliary_tract0.52690954
127MP0002277_abnormal_respiratory_mucosa0.52331204
128MP0005164_abnormal_response_to0.49546954
129MP0005381_digestive/alimentary_phenotyp0.48929918
130MP0004130_abnormal_muscle_cell0.47088298

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.37914411
2T lymphocytopenia (HP:0005403)4.17197882
3Recurrent bronchitis (HP:0002837)4.12346897
4Chronic otitis media (HP:0000389)4.05219070
5Elevated erythrocyte sedimentation rate (HP:0003565)4.04195711
6Abnormality of T cell number (HP:0011839)4.04174286
7Recurrent viral infections (HP:0004429)4.01561741
8Chronic obstructive pulmonary disease (HP:0006510)3.66188977
9Recurrent fungal infections (HP:0002841)3.64410717
10Abnormality of T cells (HP:0002843)3.61071703
11Nasal polyposis (HP:0100582)3.60112330
12Orchitis (HP:0100796)3.58787375
13Abnormality of the nasal mucosa (HP:0000433)3.47496428
14Retrobulbar optic neuritis (HP:0100654)3.46931483
15Optic neuritis (HP:0100653)3.46931483
16Abnormality of cells of the erythroid lineage (HP:0012130)3.46301705
17Abnormal number of erythroid precursors (HP:0012131)3.46146047
18Thrombocytosis (HP:0001894)3.41213455
19Recurrent gram-negative bacterial infections (HP:0005420)3.38553122
20Autoimmune thrombocytopenia (HP:0001973)3.36114223
21Agammaglobulinemia (HP:0004432)3.34470362
22Panhypogammaglobulinemia (HP:0003139)3.33097875
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.29155138
24Eczematoid dermatitis (HP:0000976)3.24902567
25Gastrointestinal inflammation (HP:0004386)3.19785563
26Inflammation of the large intestine (HP:0002037)3.15414155
27Combined immunodeficiency (HP:0005387)3.14400637
28Abnormality of T cell physiology (HP:0011840)3.12701164
29* Pustule (HP:0200039)3.07442824
30Cellulitis (HP:0100658)3.06429302
31B lymphocytopenia (HP:0010976)3.05527698
32Abnormality of B cell number (HP:0010975)3.05527698
33Increased IgE level (HP:0003212)3.01031554
34Abnormality of the heme biosynthetic pathway (HP:0010472)3.00473319
35Petechiae (HP:0000967)3.00339189
36Severe combined immunodeficiency (HP:0004430)2.97430394
37Chronic mucocutaneous candidiasis (HP:0002728)2.94573658
38Recurrent cutaneous fungal infections (HP:0011370)2.94573658
39Abnormality of the fingertips (HP:0001211)2.93143995
40Colitis (HP:0002583)2.87175480
41Myositis (HP:0100614)2.86703006
42Spontaneous hematomas (HP:0007420)2.84170013
43Gingivitis (HP:0000230)2.77616593
44Pulmonary infiltrates (HP:0002113)2.75573642
45Recurrent abscess formation (HP:0002722)2.74473928
46Lymphopenia (HP:0001888)2.74312509
47* Papilloma (HP:0012740)2.73978297
48* Verrucae (HP:0200043)2.73978297
49Chest pain (HP:0100749)2.71088929
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.70321869
51Reticulocytopenia (HP:0001896)2.68165637
52Prolonged bleeding time (HP:0003010)2.67159165
53Urticaria (HP:0001025)2.66785626
54Meningitis (HP:0001287)2.66322304
55IgG deficiency (HP:0004315)2.63543177
56Increased IgM level (HP:0003496)2.62746955
57Keratoconjunctivitis sicca (HP:0001097)2.52756059
58Leukocytosis (HP:0001974)2.51490754
59Granulocytopenia (HP:0001913)2.47718830
60Epistaxis (HP:0000421)2.47701900
61Eosinophilia (HP:0001880)2.45452886
62Slow saccadic eye movements (HP:0000514)2.44425083
63Abnormality of eosinophils (HP:0001879)2.40353452
64Keratoconjunctivitis (HP:0001096)2.35755719
65Autoimmune hemolytic anemia (HP:0001890)2.33715342
66Lymphoma (HP:0002665)2.33017126
67Vasculitis (HP:0002633)2.32366244
68Emphysema (HP:0002097)2.30146484
69Thyroiditis (HP:0100646)2.29349695
70Microcytic anemia (HP:0001935)2.28507327
71Chronic diarrhea (HP:0002028)2.28226329
72Viral hepatitis (HP:0006562)2.28053508
73Increased cerebral lipofuscin (HP:0011813)2.26910329
74Restrictive lung disease (HP:0002091)2.26784480
75Recurrent skin infections (HP:0001581)2.26555728
76Hypertensive crisis (HP:0100735)2.24194379
77Interstitial pulmonary disease (HP:0006530)2.22928260
78Recurrent bacterial skin infections (HP:0005406)2.22466414
79Pulmonary embolism (HP:0002204)2.22299867
80Bronchitis (HP:0012387)2.20747964
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20272878
82Gastrointestinal stroma tumor (HP:0100723)2.18544668
83Arterial thrombosis (HP:0004420)2.16448335
84Gingival bleeding (HP:0000225)2.15640104
85IgA deficiency (HP:0002720)2.14269093
86Abnormal platelet function (HP:0011869)2.14118530
87Impaired platelet aggregation (HP:0003540)2.14118530
88Papilledema (HP:0001085)2.13572891
89* Skin ulcer (HP:0200042)2.11795768
90Dysostosis multiplex (HP:0000943)2.10954914
91Purpura (HP:0000979)2.09524916
92Fatigue (HP:0012378)2.08173208
93Recurrent sinusitis (HP:0011108)2.07473665
94Joint swelling (HP:0001386)2.05366508
95* Basal cell carcinoma (HP:0002671)2.03552874
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.03277556
97Premature loss of primary teeth (HP:0006323)2.02475260
98Gastrointestinal infarctions (HP:0005244)2.01511711
99Anorexia (HP:0002039)2.01062931
100Stomatitis (HP:0010280)2.00817797
101Abnormality of reticulocytes (HP:0004312)1.99834440
102Hypochromic anemia (HP:0001931)1.99549223
103Cheilitis (HP:0100825)1.98994748
104Polycythemia (HP:0001901)1.98342093
105Hypergammaglobulinemia (HP:0010702)1.96754676
106Pallor (HP:0000980)1.96719719
107Poikilocytosis (HP:0004447)1.96215593
108Skin rash (HP:0000988)1.94276935
109Abnormal platelet volume (HP:0011876)1.94150654
110Abnormality of the pleura (HP:0002103)1.93155285
111Hemoptysis (HP:0002105)1.92608931
112Entropion (HP:0000621)1.91985205
113Periodontitis (HP:0000704)1.90760990
114Hypoplasia of the thymus (HP:0000778)1.90757735
115Chronic sinusitis (HP:0011109)1.89345568
116Macrocytic anemia (HP:0001972)1.88605474
117Osteomyelitis (HP:0002754)1.87967629
118Poikiloderma (HP:0001029)1.86945619
119Abnormality of macrophages (HP:0004311)1.86608721
120Mediastinal lymphadenopathy (HP:0100721)1.86254830
121Vacuolated lymphocytes (HP:0001922)1.85801283
122Loss of speech (HP:0002371)1.85704506
123Amaurosis fugax (HP:0100576)1.85647521
124Arthralgia (HP:0002829)1.84905394
125Episodic fever (HP:0001954)1.84190520
126Hematochezia (HP:0002573)1.83126797
127Increased serum ferritin (HP:0003281)1.82925762
128Sepsis (HP:0100806)1.82589465
129Multiple enchondromatosis (HP:0005701)1.82585369
130Encephalitis (HP:0002383)1.80073770
131Aplastic anemia (HP:0001915)1.79493245
132Obstructive lung disease (HP:0006536)1.78765260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.09480788
2RIPK43.76054427
3PRPF4B3.45173619
4EEF2K3.13270294
5STK102.69564852
6JAK32.55236578
7FGFR42.54052379
8MAP3K102.46767002
9NME22.46579084
10TYK22.43022386
11ZAP702.40730987
12TXK2.36602470
13GRK62.31601084
14ERN12.30838196
15PKN22.16345150
16FES2.02755247
17LRRK21.94767982
18TRIB31.94209987
19BLK1.86362701
20IKBKE1.85452625
21ITK1.77432132
22TBK11.73918777
23SIK31.68024860
24KDR1.65549188
25TGFBR21.60176997
26SIK21.58217311
27BTK1.53049189
28SMG11.46202458
29MAP2K31.41723504
30MAP3K141.40149443
31KIT1.35873037
32MAPKAPK31.32936462
33JAK11.32579338
34FGFR31.30688325
35RPS6KB21.29858949
36PIM11.26650965
37MST41.25605278
38SYK1.25117843
39LCK1.23669623
40TESK21.15416625
41MARK21.14137784
42TEC1.13174037
43NLK1.12741553
44FLT31.10923103
45RPS6KA41.09018577
46NEK21.08751808
47CDK121.06181098
48CSK1.05704116
49EPHB11.05586189
50CSF1R1.05405524
51IKBKB1.02345434
52MAP3K11.00164514
53CDC42BPA1.00066633
54HCK0.99898687
55FGR0.98626980
56MAP3K110.97762991
57PIM20.96849275
58IRAK30.95435807
59MARK30.92486905
60CAMKK10.91157383
61MAP3K80.90589168
62CDK40.89879300
63MAP3K130.89316064
64PRKD20.88457895
65PTK60.86207387
66JAK20.85451941
67STK40.85333314
68PDK10.84170375
69TGFBR10.79653275
70MAPK110.78649610
71MAP3K30.78622036
72IRAK40.78135206
73LYN0.75992827
74SCYL20.75560762
75MAPK70.74820576
76KSR20.74172347
77TTN0.73112380
78MATK0.72432225
79CLK10.68455052
80ICK0.68373582
81CHUK0.67355417
82TRPM70.66449323
83EIF2AK10.66122812
84PDPK10.63717007
85TAOK10.63316637
86BMPR20.62336360
87TAOK20.59165072
88PAK40.58513148
89CDC70.56845939
90WEE10.56602966
91TNK20.56506061
92BUB10.56312781
93MAP3K70.55846791
94PASK0.55442038
95SIK10.52962313
96FYN0.52495796
97RIPK10.51382177
98TLK10.50587433
99IRAK10.50482619
100TIE10.49879882
101TSSK60.49818912
102YES10.49752499
103TAOK30.47962016
104PRKCQ0.47880992
105RET0.47487302
106RPS6KC10.46389248
107RPS6KL10.46389248
108MST1R0.45838036
109MAP2K20.44156526
110CDK60.43654269
111TESK10.43083125
112BMX0.42553972
113HIPK20.42451071
114CAMKK20.41892946
115MAPKAPK20.41733354
116AURKB0.40912578
117TYRO30.40632288
118DYRK30.39733626
119STK160.38328149
120EIF2AK30.38252228
121IRAK20.38248010
122CDK70.37254697
123MAP2K60.36396370
124DYRK1B0.35494125
125RPS6KA50.35265188
126PRKG20.34337386
127MAPK120.33962672
128EPHA20.33529557
129PRKCH0.31922307
130ATR0.31782944
131MAP3K60.31773942
132RPS6KA60.30757067
133BCKDK0.30477988
134MAPK30.28623885

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.19456730
2Ribosome_Homo sapiens_hsa030102.61862677
3DNA replication_Homo sapiens_hsa030302.28232148
4Antigen processing and presentation_Homo sapiens_hsa046122.27519994
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.20737149
6Measles_Homo sapiens_hsa051622.16716890
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.10663672
8B cell receptor signaling pathway_Homo sapiens_hsa046622.06348244
9Type I diabetes mellitus_Homo sapiens_hsa049402.05268399
10Hematopoietic cell lineage_Homo sapiens_hsa046402.04353652
11T cell receptor signaling pathway_Homo sapiens_hsa046602.04341319
12Leishmaniasis_Homo sapiens_hsa051401.94223124
13Asthma_Homo sapiens_hsa053101.84514492
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81567400
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70261515
16Base excision repair_Homo sapiens_hsa034101.68480049
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67826653
18Herpes simplex infection_Homo sapiens_hsa051681.65949123
19Osteoclast differentiation_Homo sapiens_hsa043801.60279776
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53562172
21Mismatch repair_Homo sapiens_hsa034301.49571139
22Acute myeloid leukemia_Homo sapiens_hsa052211.44765716
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.42947961
24Toxoplasmosis_Homo sapiens_hsa051451.42800745
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.36435184
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31811685
27Apoptosis_Homo sapiens_hsa042101.26088157
28Influenza A_Homo sapiens_hsa051641.23660379
29Hepatitis B_Homo sapiens_hsa051611.23351059
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22533519
31Chronic myeloid leukemia_Homo sapiens_hsa052201.20681700
32Other glycan degradation_Homo sapiens_hsa005111.20582579
33Spliceosome_Homo sapiens_hsa030401.19847340
34Viral myocarditis_Homo sapiens_hsa054161.18450266
35p53 signaling pathway_Homo sapiens_hsa041151.16399500
36Shigellosis_Homo sapiens_hsa051311.15918061
37Small cell lung cancer_Homo sapiens_hsa052221.13813041
38Legionellosis_Homo sapiens_hsa051341.12654617
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11770004
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07844754
41Epstein-Barr virus infection_Homo sapiens_hsa051691.05224647
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04919738
43Non-homologous end-joining_Homo sapiens_hsa034501.04235523
44One carbon pool by folate_Homo sapiens_hsa006701.03344195
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.03147687
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01696827
47Viral carcinogenesis_Homo sapiens_hsa052031.01653894
48HTLV-I infection_Homo sapiens_hsa051660.98617277
49Caffeine metabolism_Homo sapiens_hsa002320.97872434
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94452214
51Pancreatic cancer_Homo sapiens_hsa052120.94049111
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92919532
53Hepatitis C_Homo sapiens_hsa051600.91573806
54Rheumatoid arthritis_Homo sapiens_hsa053230.90459004
55Platelet activation_Homo sapiens_hsa046110.90330645
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89374833
57Homologous recombination_Homo sapiens_hsa034400.89037062
58Staphylococcus aureus infection_Homo sapiens_hsa051500.88257015
59Allograft rejection_Homo sapiens_hsa053300.87880631
60Sulfur relay system_Homo sapiens_hsa041220.85805931
61Nucleotide excision repair_Homo sapiens_hsa034200.85690843
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85159445
63Malaria_Homo sapiens_hsa051440.84549029
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83500513
65Cell cycle_Homo sapiens_hsa041100.83384155
66Pentose phosphate pathway_Homo sapiens_hsa000300.82777719
67Thyroid cancer_Homo sapiens_hsa052160.82733579
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82401507
69Pyrimidine metabolism_Homo sapiens_hsa002400.82289114
70TNF signaling pathway_Homo sapiens_hsa046680.81916127
71Graft-versus-host disease_Homo sapiens_hsa053320.81231448
72RNA transport_Homo sapiens_hsa030130.81166961
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80706796
74Renal cell carcinoma_Homo sapiens_hsa052110.80181086
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79741574
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78806559
77Non-small cell lung cancer_Homo sapiens_hsa052230.78715459
78Chemokine signaling pathway_Homo sapiens_hsa040620.76988031
79Inositol phosphate metabolism_Homo sapiens_hsa005620.74907108
80Choline metabolism in cancer_Homo sapiens_hsa052310.74812800
81Phagosome_Homo sapiens_hsa041450.73846952
82mTOR signaling pathway_Homo sapiens_hsa041500.72424692
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.72089716
84Tuberculosis_Homo sapiens_hsa051520.71802999
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71322353
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71282946
87Pertussis_Homo sapiens_hsa051330.71227494
88Endometrial cancer_Homo sapiens_hsa052130.70813609
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70311002
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68986145
91African trypanosomiasis_Homo sapiens_hsa051430.67494535
92Systemic lupus erythematosus_Homo sapiens_hsa053220.64402708
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64088265
94Folate biosynthesis_Homo sapiens_hsa007900.64025656
95VEGF signaling pathway_Homo sapiens_hsa043700.63596096
96Endocytosis_Homo sapiens_hsa041440.62501668
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61743291
98Proteasome_Homo sapiens_hsa030500.61538093
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.61352287
100Notch signaling pathway_Homo sapiens_hsa043300.60884321
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.59534905
102GnRH signaling pathway_Homo sapiens_hsa049120.57984196
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.57074858
104N-Glycan biosynthesis_Homo sapiens_hsa005100.56926237
105RNA degradation_Homo sapiens_hsa030180.55499097
106Prolactin signaling pathway_Homo sapiens_hsa049170.54649403
107FoxO signaling pathway_Homo sapiens_hsa040680.54442512
108Autoimmune thyroid disease_Homo sapiens_hsa053200.54434565
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51759823
110Insulin resistance_Homo sapiens_hsa049310.51733331
111Colorectal cancer_Homo sapiens_hsa052100.49658197
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.48559590
113RNA polymerase_Homo sapiens_hsa030200.47490792
114ErbB signaling pathway_Homo sapiens_hsa040120.47221020
115ABC transporters_Homo sapiens_hsa020100.47134391
116Salmonella infection_Homo sapiens_hsa051320.46518307
117MAPK signaling pathway_Homo sapiens_hsa040100.46390928
118Prostate cancer_Homo sapiens_hsa052150.44520777
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43484740
120Lysine degradation_Homo sapiens_hsa003100.42661405
121Selenocompound metabolism_Homo sapiens_hsa004500.42344948
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42017029
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39804171
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.39747514
125Insulin signaling pathway_Homo sapiens_hsa049100.39126452
126MicroRNAs in cancer_Homo sapiens_hsa052060.38733326
127Renin-angiotensin system_Homo sapiens_hsa046140.38574283
128HIF-1 signaling pathway_Homo sapiens_hsa040660.35874180
129Lysosome_Homo sapiens_hsa041420.35750955
130Type II diabetes mellitus_Homo sapiens_hsa049300.35471858
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35079337
132Glioma_Homo sapiens_hsa052140.30666298
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29883741
134Long-term potentiation_Homo sapiens_hsa047200.29615683
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29168190
136Rap1 signaling pathway_Homo sapiens_hsa040150.29135442

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