TMC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.86013173
2motile cilium assembly (GO:0044458)5.80548680
3central nervous system myelination (GO:0022010)5.58565986
4axon ensheathment in central nervous system (GO:0032291)5.58565986
5acrosome reaction (GO:0007340)5.46401909
6fusion of sperm to egg plasma membrane (GO:0007342)5.43766662
7sperm motility (GO:0030317)4.99694614
8cilium or flagellum-dependent cell motility (GO:0001539)4.78162859
9epithelial cilium movement (GO:0003351)4.70628111
10axonemal dynein complex assembly (GO:0070286)4.68993417
11cell wall macromolecule catabolic process (GO:0016998)4.67959135
12cell wall macromolecule metabolic process (GO:0044036)4.67959135
13multicellular organism reproduction (GO:0032504)4.49381263
14fucose catabolic process (GO:0019317)4.48544264
15L-fucose metabolic process (GO:0042354)4.48544264
16L-fucose catabolic process (GO:0042355)4.48544264
17response to pheromone (GO:0019236)4.48244064
18L-amino acid import (GO:0043092)4.45205560
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.38760432
20acrosome assembly (GO:0001675)4.36394003
21amino acid import (GO:0043090)4.24873861
22piRNA metabolic process (GO:0034587)4.19746188
23plasma membrane fusion (GO:0045026)4.18741915
24C4-dicarboxylate transport (GO:0015740)4.02394971
25cilium movement (GO:0003341)3.99104781
26gamma-aminobutyric acid transport (GO:0015812)3.76255085
27sperm-egg recognition (GO:0035036)3.69549454
28spermatid development (GO:0007286)3.69166868
29reproduction (GO:0000003)3.62443597
30regulation of cilium movement (GO:0003352)3.55735170
31atrial cardiac muscle cell action potential (GO:0086014)3.54445256
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.50725361
33presynaptic membrane assembly (GO:0097105)3.50145379
34myelination (GO:0042552)3.49648306
35sperm capacitation (GO:0048240)3.47078766
36axon ensheathment (GO:0008366)3.45084149
37ensheathment of neurons (GO:0007272)3.45084149
38male meiosis (GO:0007140)3.44716128
39negative regulation of inclusion body assembly (GO:0090084)3.42121307
40presynaptic membrane organization (GO:0097090)3.32723722
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32494932
42fatty acid elongation (GO:0030497)3.29221454
43meiotic chromosome segregation (GO:0045132)3.28562141
44L-serine transport (GO:0015825)3.26795100
45DNA methylation involved in gamete generation (GO:0043046)3.23377033
46cellular ketone body metabolic process (GO:0046950)3.18887612
47single fertilization (GO:0007338)3.18759495
48cell-cell recognition (GO:0009988)3.16857742
49calcium ion-dependent exocytosis (GO:0017156)3.16493173
50DNA deamination (GO:0045006)3.16386486
51neuron cell-cell adhesion (GO:0007158)3.15202547
52protein polyglutamylation (GO:0018095)3.13519597
53indole-containing compound catabolic process (GO:0042436)3.13425181
54indolalkylamine catabolic process (GO:0046218)3.13425181
55tryptophan catabolic process (GO:0006569)3.13425181
56establishment of mitochondrion localization (GO:0051654)3.12863922
57detection of light stimulus involved in visual perception (GO:0050908)3.08051672
58detection of light stimulus involved in sensory perception (GO:0050962)3.08051672
59negative regulation of telomere maintenance (GO:0032205)3.05735612
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04689613
61negative regulation of neurotransmitter secretion (GO:0046929)3.02253270
62binding of sperm to zona pellucida (GO:0007339)3.02004279
63kynurenine metabolic process (GO:0070189)3.01719632
64negative regulation of neurotransmitter transport (GO:0051589)3.00497842
65platelet dense granule organization (GO:0060155)3.00149553
66nonmotile primary cilium assembly (GO:0035058)2.99366310
67peripheral nervous system axon ensheathment (GO:0032292)2.99175155
68myelination in peripheral nervous system (GO:0022011)2.99175155
69ventricular system development (GO:0021591)2.97285011
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95793884
71protein K11-linked deubiquitination (GO:0035871)2.92175049
72cerebral cortex radially oriented cell migration (GO:0021799)2.90051709
73water-soluble vitamin biosynthetic process (GO:0042364)2.88252138
74indolalkylamine metabolic process (GO:0006586)2.88141761
75glutamate receptor signaling pathway (GO:0007215)2.86289113
76negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85131591
77neuronal action potential propagation (GO:0019227)2.83916742
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.83621323
79alanine transport (GO:0032328)2.82760957
80protein-cofactor linkage (GO:0018065)2.82306245
81ketone body metabolic process (GO:1902224)2.82163586
82synaptonemal complex organization (GO:0070193)2.81533300
83cellular potassium ion homeostasis (GO:0030007)2.77648124
84response to methylmercury (GO:0051597)2.77593774
85organic cation transport (GO:0015695)2.76869573
86negative regulation of astrocyte differentiation (GO:0048712)2.76127737
87proline transport (GO:0015824)2.75119208
88rRNA catabolic process (GO:0016075)2.75057194
89neuronal action potential (GO:0019228)2.74353166
90cornea development in camera-type eye (GO:0061303)2.74190422
91pyrimidine nucleobase catabolic process (GO:0006208)2.74043933
92neurotransmitter uptake (GO:0001504)2.73449393
93aggressive behavior (GO:0002118)2.73052230
94kidney morphogenesis (GO:0060993)2.71223592
95regulation of inclusion body assembly (GO:0090083)2.70751140
96serine transport (GO:0032329)2.69955257
97oligodendrocyte differentiation (GO:0048709)2.69935405
98peptidyl-tyrosine autophosphorylation (GO:0038083)2.68811570
99axoneme assembly (GO:0035082)2.68717463
100fertilization (GO:0009566)2.68550050
101synaptic transmission, glutamatergic (GO:0035249)2.68401296
102nephron tubule morphogenesis (GO:0072078)2.68382880
103nephron epithelium morphogenesis (GO:0072088)2.68382880
104eye photoreceptor cell differentiation (GO:0001754)2.68224567
105photoreceptor cell differentiation (GO:0046530)2.68224567
106retina layer formation (GO:0010842)2.67865763
107auditory receptor cell stereocilium organization (GO:0060088)2.67597098
108RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66328977
109retinal cone cell development (GO:0046549)2.65895254
110reciprocal meiotic recombination (GO:0007131)2.65837201
111reciprocal DNA recombination (GO:0035825)2.65837201
112preassembly of GPI anchor in ER membrane (GO:0016254)2.65220823
113negative regulation of protein localization to cell surface (GO:2000009)2.64030033
114photoreceptor cell maintenance (GO:0045494)2.63381405
115glycerophospholipid catabolic process (GO:0046475)2.63361887
116DNA double-strand break processing (GO:0000729)2.62367405
117response to auditory stimulus (GO:0010996)2.62324118
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60237219
119Golgi to endosome transport (GO:0006895)2.60150720
120limb bud formation (GO:0060174)2.58983650
121cerebellar granule cell differentiation (GO:0021707)2.57991514
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57656070
123behavioral response to ethanol (GO:0048149)2.56396924
124regulation of hippo signaling (GO:0035330)2.55537788
125potassium ion import (GO:0010107)2.55292839
126regulation of meiosis I (GO:0060631)2.54979036
127tryptophan metabolic process (GO:0006568)2.54141155
128regulation of hexokinase activity (GO:1903299)2.54122132
129regulation of glucokinase activity (GO:0033131)2.54122132
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53806057
131primary amino compound metabolic process (GO:1901160)2.53753519
132left/right pattern formation (GO:0060972)2.53542097
133regulation of action potential (GO:0098900)2.53475428
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.53407776
135nucleobase catabolic process (GO:0046113)2.53393197
136fucosylation (GO:0036065)2.51940129
137positive regulation of oligodendrocyte differentiation (GO:0048714)2.50143236
138reflex (GO:0060004)2.49990589
139spinal cord motor neuron differentiation (GO:0021522)2.49901028
140regulation of mesoderm development (GO:2000380)2.49752536
141synaptonemal complex assembly (GO:0007130)2.48136050
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48022760
143mitochondrion transport along microtubule (GO:0047497)2.48022760
144detection of temperature stimulus (GO:0016048)2.47641510
145exogenous drug catabolic process (GO:0042738)2.47033386
146asymmetric protein localization (GO:0008105)2.46330859
147spermatogenesis (GO:0007283)2.46028358
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.45870048
149postsynaptic membrane organization (GO:0001941)2.45691097
150negative regulation of reactive oxygen species metabolic process (GO:2000378)2.45386121
151sulfation (GO:0051923)2.45208694
152regulation of neurotransmitter uptake (GO:0051580)2.45046298
153transmission of nerve impulse (GO:0019226)2.44984901
154male gamete generation (GO:0048232)2.44587969
155male meiosis I (GO:0007141)2.44518158
156lateral sprouting from an epithelium (GO:0060601)2.42993069
157detection of mechanical stimulus involved in sensory perception (GO:0050974)2.42840642
158adenine nucleotide transport (GO:0051503)2.42652687
159regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.42329534
160regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41903163
161indole-containing compound metabolic process (GO:0042430)2.41801586
162intraciliary transport (GO:0042073)2.41614694
163synaptic transmission, cholinergic (GO:0007271)2.41190993
164regulation of microtubule-based movement (GO:0060632)2.40384201
165recombinational repair (GO:0000725)2.40194645
166double-strand break repair via homologous recombination (GO:0000724)2.39854744
167cilium morphogenesis (GO:0060271)2.39396382
168auditory behavior (GO:0031223)2.38251495
169regulation of rhodopsin mediated signaling pathway (GO:0022400)2.38216858
170positive regulation of fatty acid transport (GO:2000193)2.37954971
171synapsis (GO:0007129)2.36907098
172basic amino acid transport (GO:0015802)2.36891289
173inner ear receptor stereocilium organization (GO:0060122)2.36831570
174protein complex biogenesis (GO:0070271)2.36224712
175purine nucleotide transport (GO:0015865)2.35436198
176purine ribonucleotide transport (GO:0015868)2.34876948
177positive regulation of potassium ion transport (GO:0043268)2.34851652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.06349582
2GBX2_23144817_ChIP-Seq_PC3_Human3.57483517
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79901655
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71003942
5IGF1R_20145208_ChIP-Seq_DFB_Human2.57085248
6TAF15_26573619_Chip-Seq_HEK293_Human2.09461215
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01546905
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01266522
9CBX2_27304074_Chip-Seq_ESCs_Mouse1.94044807
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91124498
11EWS_26573619_Chip-Seq_HEK293_Human1.90478073
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82069962
13VDR_22108803_ChIP-Seq_LS180_Human1.75572325
14AR_21572438_ChIP-Seq_LNCaP_Human1.75084175
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74517527
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72921777
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71794827
18SALL1_21062744_ChIP-ChIP_HESCs_Human1.70908312
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70159025
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66176119
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64075550
22REST_21632747_ChIP-Seq_MESCs_Mouse1.61986457
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60130799
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60129699
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59732083
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58307927
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57657260
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57523312
29SMAD4_21799915_ChIP-Seq_A2780_Human1.56839885
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.56578196
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56307817
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.56303468
33CBP_20019798_ChIP-Seq_JUKART_Human1.55359007
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55359007
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55099854
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54416688
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.54201072
38P300_19829295_ChIP-Seq_ESCs_Human1.52745588
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51861001
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50707709
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50037582
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48279434
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48265683
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48086151
45IRF1_19129219_ChIP-ChIP_H3396_Human1.47249198
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46792876
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46792876
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46658784
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.46619147
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.46475390
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46304271
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.46208627
53TP53_22573176_ChIP-Seq_HFKS_Human1.45670910
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45643098
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.44804853
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.44727267
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40385756
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39896753
59FUS_26573619_Chip-Seq_HEK293_Human1.39299217
60NANOG_19829295_ChIP-Seq_ESCs_Human1.37376179
61SOX2_19829295_ChIP-Seq_ESCs_Human1.37376179
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37242214
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36572807
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35616258
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34424891
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34388334
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33874719
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33874719
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33738659
70ER_23166858_ChIP-Seq_MCF-7_Human1.33630682
71MYC_18940864_ChIP-ChIP_HL60_Human1.33372309
72* STAT3_23295773_ChIP-Seq_U87_Human1.33177078
73DROSHA_22980978_ChIP-Seq_HELA_Human1.32963285
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31411784
75RNF2_27304074_Chip-Seq_NSC_Mouse1.31405712
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30849512
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30544440
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.29930127
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29343786
80TCF4_22108803_ChIP-Seq_LS180_Human1.29249747
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28920651
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28615441
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.27986671
84AR_25329375_ChIP-Seq_VCAP_Human1.27144387
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27087356
86TCF4_23295773_ChIP-Seq_U87_Human1.25589173
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.25147876
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25147876
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25125426
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23834627
91HOXB7_26014856_ChIP-Seq_BT474_Human1.22909924
92NCOR_22424771_ChIP-Seq_293T_Human1.22486013
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.22207715
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21490433
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.21458000
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.20720110
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20697754
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20254326
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.20031632
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19863613
101ZNF274_21170338_ChIP-Seq_K562_Hela1.19374689
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18998730
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.18107917
104P53_22387025_ChIP-Seq_ESCs_Mouse1.17538232
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17020846
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16976413
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16576363
108P300_18555785_Chip-Seq_ESCs_Mouse1.15608021
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14662054
110* REST_18959480_ChIP-ChIP_MESCs_Mouse1.14124905
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.11775261
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.09719949
113* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08820092
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.08798709
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08720163
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.07217120
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07194960
118AHR_22903824_ChIP-Seq_MCF-7_Human1.06558372
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06184782
120KDM2B_26808549_Chip-Seq_REH_Human1.06083701
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.05872204
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05452936
123BCAT_22108803_ChIP-Seq_LS180_Human1.05257029
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04080266
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.03758054
126MYC_19829295_ChIP-Seq_ESCs_Human1.03699226
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03351846
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02981357
129TBL1_22424771_ChIP-Seq_293T_Human1.01737095
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.01058004
131* AR_20517297_ChIP-Seq_VCAP_Human1.00698763
132ERA_21632823_ChIP-Seq_H3396_Human1.00500444
133SOX2_18555785_Chip-Seq_ESCs_Mouse1.00009819
134CDX2_22108803_ChIP-Seq_LS180_Human0.99714374
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99412762
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98214394
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.97925512
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.97817497
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97421431
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97024585
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96212389
142NANOG_20526341_ChIP-Seq_ESCs_Human0.95724350
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.95349177
144EST1_17652178_ChIP-ChIP_JURKAT_Human0.94482952
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.94318104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.42449961
2MP0003136_yellow_coat_color4.49616251
3MP0005670_abnormal_white_adipose4.26486259
4MP0004270_analgesia3.79986482
5MP0005171_absent_coat_pigmentation2.87808552
6MP0003690_abnormal_glial_cell2.66967655
7MP0005409_darkened_coat_color2.61684963
8MP0001486_abnormal_startle_reflex2.37046146
9MP0003950_abnormal_plasma_membrane2.23958747
10MP0006292_abnormal_olfactory_placode2.23658805
11MP0004147_increased_porphyrin_level2.23548144
12MP0009046_muscle_twitch2.20777409
13MP0000920_abnormal_myelination2.17074093
14MP0004885_abnormal_endolymph2.17042218
15MP0003880_abnormal_central_pattern2.17011842
16MP0004859_abnormal_synaptic_plasticity2.12331797
17MP0008875_abnormal_xenobiotic_pharmacok2.07770754
18MP0003698_abnormal_male_reproductive2.05593531
19MP0003195_calcinosis2.02130435
20MP0004742_abnormal_vestibular_system2.01607732
21MP0002734_abnormal_mechanical_nocicepti1.99821783
22MP0008872_abnormal_physiological_respon1.92360280
23MP0002102_abnormal_ear_morphology1.91782100
24MP0002876_abnormal_thyroid_physiology1.88212829
25MP0001440_abnormal_grooming_behavior1.85725399
26MP0000566_synostosis1.85116114
27MP0003635_abnormal_synaptic_transmissio1.84587422
28MP0002735_abnormal_chemical_nociception1.81287639
29MP0000778_abnormal_nervous_system1.81250485
30MP0003646_muscle_fatigue1.80910955
31MP0009745_abnormal_behavioral_response1.79759045
32MP0001986_abnormal_taste_sensitivity1.78938487
33MP0002064_seizures1.73027152
34MP0008877_abnormal_DNA_methylation1.71041155
35MP0002272_abnormal_nervous_system1.70176481
36MP0002572_abnormal_emotion/affect_behav1.70068064
37MP0005423_abnormal_somatic_nervous1.66692706
38MP0002234_abnormal_pharynx_morphology1.66468369
39MP0001485_abnormal_pinna_reflex1.65261768
40MP0000427_abnormal_hair_cycle1.65099549
41MP0003634_abnormal_glial_cell1.58879761
42MP0006072_abnormal_retinal_apoptosis1.57299768
43MP0002837_dystrophic_cardiac_calcinosis1.56804650
44MP0005645_abnormal_hypothalamus_physiol1.55951350
45MP0004133_heterotaxia1.52645880
46MP0001929_abnormal_gametogenesis1.51771875
47MP0001529_abnormal_vocalization1.48636051
48MP0002653_abnormal_ependyma_morphology1.48081981
49MP0002822_catalepsy1.47480075
50MP0002063_abnormal_learning/memory/cond1.45446324
51MP0005623_abnormal_meninges_morphology1.42934843
52MP0003633_abnormal_nervous_system1.40941891
53MP0001502_abnormal_circadian_rhythm1.39294224
54MP0009384_cardiac_valve_regurgitation1.38817915
55MP0000372_irregular_coat_pigmentation1.38074419
56MP0003718_maternal_effect1.36236716
57MP0003011_delayed_dark_adaptation1.34586559
58MP0004142_abnormal_muscle_tone1.34342560
59MP0003631_nervous_system_phenotype1.34020392
60MP0001968_abnormal_touch/_nociception1.33643983
61MP0002938_white_spotting1.33412684
62MP0005551_abnormal_eye_electrophysiolog1.32907968
63MP0005167_abnormal_blood-brain_barrier1.32006110
64MP0002067_abnormal_sensory_capabilities1.29258536
65MP0005646_abnormal_pituitary_gland1.29137155
66MP0001984_abnormal_olfaction1.28451634
67MP0003632_abnormal_nervous_system1.26977083
68MP0001963_abnormal_hearing_physiology1.24711595
69MP0002160_abnormal_reproductive_system1.24336383
70MP0002557_abnormal_social/conspecific_i1.24092165
71MP0010386_abnormal_urinary_bladder1.21575123
72MP0001905_abnormal_dopamine_level1.21128427
73MP0005085_abnormal_gallbladder_physiolo1.20842726
74MP0000955_abnormal_spinal_cord1.20705406
75MP0003329_amyloid_beta_deposits1.19275122
76MP0005451_abnormal_body_composition1.18736526
77MP0002638_abnormal_pupillary_reflex1.17864053
78MP0002736_abnormal_nociception_after1.17276874
79MP0005389_reproductive_system_phenotype1.16652519
80MP0005386_behavior/neurological_phenoty1.15481382
81MP0004924_abnormal_behavior1.15481382
82MP0005084_abnormal_gallbladder_morpholo1.14606856
83MP0008569_lethality_at_weaning1.12461651
84MP0003122_maternal_imprinting1.08285516
85MP0002733_abnormal_thermal_nociception1.07759727
86MP0008789_abnormal_olfactory_epithelium1.06522753
87MP0002229_neurodegeneration1.06422133
88MP0002882_abnormal_neuron_morphology1.05252201
89MP0009780_abnormal_chondrocyte_physiolo1.04042311
90MP0009697_abnormal_copulation1.03891649
91MP0000462_abnormal_digestive_system1.03272704
92MP0004858_abnormal_nervous_system1.01290764
93MP0001970_abnormal_pain_threshold1.00945705
94MP0003119_abnormal_digestive_system0.99745215
95MP0005377_hearing/vestibular/ear_phenot0.99015645
96MP0003878_abnormal_ear_physiology0.99015645
97MP0002161_abnormal_fertility/fecundity0.98861493
98MP0004043_abnormal_pH_regulation0.98745176
99MP0008775_abnormal_heart_ventricle0.93854087
100MP0002066_abnormal_motor_capabilities/c0.93700730
101MP0005174_abnormal_tail_pigmentation0.92685364
102MP0002184_abnormal_innervation0.92402339
103MP0001919_abnormal_reproductive_system0.92344907
104MP0001299_abnormal_eye_distance/0.92196210
105MP0005253_abnormal_eye_physiology0.91081854
106MP0002152_abnormal_brain_morphology0.90652102
107MP0002751_abnormal_autonomic_nervous0.90407670
108MP0004145_abnormal_muscle_electrophysio0.89499299
109MP0001177_atelectasis0.88491307
110MP0002210_abnormal_sex_determination0.88089315
111MP0002909_abnormal_adrenal_gland0.87825315
112MP0000026_abnormal_inner_ear0.86808950
113MP0000383_abnormal_hair_follicle0.85542024
114MP0008058_abnormal_DNA_repair0.84021695
115MP0003283_abnormal_digestive_organ0.83216185
116MP0003137_abnormal_impulse_conducting0.82603040
117MP0000230_abnormal_systemic_arterial0.81424904
118MP0000049_abnormal_middle_ear0.80826908
119MP0000647_abnormal_sebaceous_gland0.80598765
120MP0002752_abnormal_somatic_nervous0.79581883
121MP0002089_abnormal_postnatal_growth/wei0.79084431
122MP0001501_abnormal_sleep_pattern0.73916175
123MP0004215_abnormal_myocardial_fiber0.73579663
124MP0006276_abnormal_autonomic_nervous0.72963293
125MP0001661_extended_life_span0.71826913
126MP0005666_abnormal_adipose_tissue0.71796811
127MP0003183_abnormal_peptide_metabolism0.71692836
128MP0003045_fibrosis0.68783402
129MP0000631_abnormal_neuroendocrine_gland0.68337967
130MP0003937_abnormal_limbs/digits/tail_de0.67575352
131MP0001145_abnormal_male_reproductive0.67208622
132MP0003787_abnormal_imprinting0.65389681
133MP0004484_altered_response_of0.65339989
134MP0000579_abnormal_nail_morphology0.64995229
135MP0005195_abnormal_posterior_eye0.64989782
136MP0005647_abnormal_sex_gland0.64775068

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.28320880
2Absent/shortened dynein arms (HP:0200106)7.28320880
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.94550362
4Abnormal respiratory motile cilium physiology (HP:0012261)5.05982641
5Aplasia involving bones of the extremities (HP:0009825)4.84137306
6Aplasia involving bones of the upper limbs (HP:0009823)4.84137306
7Aplasia of the phalanges of the hand (HP:0009802)4.84137306
8Abnormal respiratory epithelium morphology (HP:0012253)4.61722065
9Abnormal respiratory motile cilium morphology (HP:0005938)4.61722065
10Abnormal ciliary motility (HP:0012262)4.38629798
11Pancreatic cysts (HP:0001737)4.06017026
12Alopecia of scalp (HP:0002293)3.68902763
13Type II lissencephaly (HP:0007260)3.46397620
14Follicular hyperkeratosis (HP:0007502)3.44494281
15Congenital stationary night blindness (HP:0007642)3.40459807
16Rhinitis (HP:0012384)3.38796578
17Neurofibrillary tangles (HP:0002185)3.23533745
18Pheochromocytoma (HP:0002666)3.23337979
19Hyperventilation (HP:0002883)3.03719693
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00465627
21Abnormality of alanine metabolism (HP:0010916)3.00465627
22Hyperalaninemia (HP:0003348)3.00465627
23Neuroendocrine neoplasm (HP:0100634)2.98164677
24Attenuation of retinal blood vessels (HP:0007843)2.89396687
25Abnormality of the renal cortex (HP:0011035)2.87714027
26Nephronophthisis (HP:0000090)2.77930462
27Tubular atrophy (HP:0000092)2.76951557
28Inability to walk (HP:0002540)2.76365413
29Hemiparesis (HP:0001269)2.72062266
30Cystic liver disease (HP:0006706)2.62021324
31Lissencephaly (HP:0001339)2.61916237
32Epileptic encephalopathy (HP:0200134)2.59645953
33Cerebellar dysplasia (HP:0007033)2.59129275
34Focal motor seizures (HP:0011153)2.55589725
35Hypoplastic left heart (HP:0004383)2.54334085
36Abolished electroretinogram (ERG) (HP:0000550)2.52511616
37Abnormal drinking behavior (HP:0030082)2.50698412
38Polydipsia (HP:0001959)2.50698412
39Abnormal rod and cone electroretinograms (HP:0008323)2.48217884
40Chronic bronchitis (HP:0004469)2.47592330
41Infertility (HP:0000789)2.41320723
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41191343
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.41191343
44Progressive cerebellar ataxia (HP:0002073)2.40045167
45Thyroid-stimulating hormone excess (HP:0002925)2.39807808
46Progressive inability to walk (HP:0002505)2.37595488
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.36841456
48Sclerocornea (HP:0000647)2.35986406
49Abnormality of the dental root (HP:0006486)2.35592857
50Taurodontia (HP:0000679)2.35592857
51Abnormality of permanent molar morphology (HP:0011071)2.35592857
52Broad-based gait (HP:0002136)2.33301096
53Pendular nystagmus (HP:0012043)2.33217310
54Peripheral hypomyelination (HP:0007182)2.30874739
55Bilateral microphthalmos (HP:0007633)2.30707237
56Abnormality of the renal medulla (HP:0100957)2.29300677
57Chronic hepatic failure (HP:0100626)2.28917033
58Cerebral inclusion bodies (HP:0100314)2.26594333
59Abnormality of the dental pulp (HP:0006479)2.25793452
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25375067
61Abnormality of molar (HP:0011077)2.24917146
62Abnormality of molar morphology (HP:0011070)2.24917146
63Increased corneal curvature (HP:0100692)2.22659523
64Keratoconus (HP:0000563)2.22659523
65Clumsiness (HP:0002312)2.22411949
66Large for gestational age (HP:0001520)2.22305565
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21566520
68Long nose (HP:0003189)2.19696188
69Medial flaring of the eyebrow (HP:0010747)2.18624004
70Humeroradial synostosis (HP:0003041)2.17122413
71Synostosis involving the elbow (HP:0003938)2.17122413
72Decreased central vision (HP:0007663)2.16037770
73Polyuria (HP:0000103)2.15300075
74Bile duct proliferation (HP:0001408)2.14957535
75Abnormal biliary tract physiology (HP:0012439)2.14957535
76Occipital encephalocele (HP:0002085)2.13819395
77Pancreatic fibrosis (HP:0100732)2.13741400
78Onion bulb formation (HP:0003383)2.13390956
79Blue irides (HP:0000635)2.12796023
80Tubulointerstitial nephritis (HP:0001970)2.11217619
81Concave nail (HP:0001598)2.10553468
82Nephrogenic diabetes insipidus (HP:0009806)2.10253762
83Ectropion (HP:0000656)2.10028606
84Bony spicule pigmentary retinopathy (HP:0007737)2.08809674
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07554015
86Bell-shaped thorax (HP:0001591)2.06344066
87Action tremor (HP:0002345)2.04501531
88Abnormality of midbrain morphology (HP:0002418)2.04235808
89Molar tooth sign on MRI (HP:0002419)2.04235808
90Megalencephaly (HP:0001355)2.03564816
91Genital tract atresia (HP:0001827)1.99732624
92Retinal dysplasia (HP:0007973)1.99038971
93Intestinal atresia (HP:0011100)1.98540679
94Vaginal atresia (HP:0000148)1.97993178
95Pachygyria (HP:0001302)1.97610487
96Dialeptic seizures (HP:0011146)1.96144713
97Methylmalonic acidemia (HP:0002912)1.95597076
98Hyperglycinuria (HP:0003108)1.95564102
99Abnormality of the corticospinal tract (HP:0002492)1.94922572
100Hypoplastic heart (HP:0001961)1.94427007
101Decreased circulating renin level (HP:0003351)1.93720845
102Retinal atrophy (HP:0001105)1.93143713
103Anophthalmia (HP:0000528)1.91445407
104Short tibia (HP:0005736)1.91106714
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.91095285
106Hypoplasia of the fovea (HP:0007750)1.91095285
107Amelogenesis imperfecta (HP:0000705)1.90901470
108Homocystinuria (HP:0002156)1.88678819
109Abnormality of homocysteine metabolism (HP:0010919)1.88678819
110Gaze-evoked nystagmus (HP:0000640)1.86463176
111Anencephaly (HP:0002323)1.85737196
112Gastrointestinal atresia (HP:0002589)1.83625804
113Short hallux (HP:0010109)1.81859694
114Steppage gait (HP:0003376)1.81784020
115Gait imbalance (HP:0002141)1.81023469
116Hypoplastic pelvis (HP:0008839)1.80751215
117Severe muscular hypotonia (HP:0006829)1.80443188
118Patellar aplasia (HP:0006443)1.80300684
119Dysdiadochokinesis (HP:0002075)1.79893085
120Furrowed tongue (HP:0000221)1.79773322
121Postaxial foot polydactyly (HP:0001830)1.79743158
122Absent speech (HP:0001344)1.79678265
123Insidious onset (HP:0003587)1.79675652
124Termporal pattern (HP:0011008)1.79675652
125Aplasia/hypoplasia of the uterus (HP:0008684)1.79337652
126CNS hypomyelination (HP:0003429)1.79277401
127Supranuclear gaze palsy (HP:0000605)1.78052854
128Aplasia/Hypoplasia of the patella (HP:0006498)1.77938322
129Male pseudohermaphroditism (HP:0000037)1.76835624
130Hyperglycinemia (HP:0002154)1.76072441
131Abnormal urine output (HP:0012590)1.75070085
132Acute necrotizing encephalopathy (HP:0006965)1.74789697
133Hypomagnesemia (HP:0002917)1.74703194
134Limb dystonia (HP:0002451)1.74633943
135Median cleft lip (HP:0000161)1.74586946
136Thickened helices (HP:0000391)1.74229005
137Abnormality of dental color (HP:0011073)1.74096920
138Sensory axonal neuropathy (HP:0003390)1.73706491
139Hypoplasia of the uterus (HP:0000013)1.73139874
140Male infertility (HP:0003251)1.72497898
1413-Methylglutaconic aciduria (HP:0003535)1.72044795
142White forelock (HP:0002211)1.71286305
143Abnormal auditory evoked potentials (HP:0006958)1.70561002
144Disproportionate short-trunk short stature (HP:0003521)1.70504609
145Anteriorly placed anus (HP:0001545)1.70314237
146Broad alveolar ridges (HP:0000187)1.70187554
147Abnormality of the pons (HP:0007361)1.69768411
148Chorioretinal atrophy (HP:0000533)1.69134709
149Midline defect of the nose (HP:0004122)1.68973947
150Abnormality of binocular vision (HP:0011514)1.68802399
151Diplopia (HP:0000651)1.68802399
152Delayed CNS myelination (HP:0002188)1.68791281
153Renal cortical cysts (HP:0000803)1.68693383
154Acute encephalopathy (HP:0006846)1.68519975
155Febrile seizures (HP:0002373)1.68343629
156Congenital primary aphakia (HP:0007707)1.66544909
157Focal seizures (HP:0007359)1.66504885
158Spastic tetraparesis (HP:0001285)1.65004894
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.64355271
160Microglossia (HP:0000171)1.63922693
161Renal dysplasia (HP:0000110)1.63910155
162Paraparesis (HP:0002385)1.62832350
163Atonic seizures (HP:0010819)1.62757313
164Mixed hearing impairment (HP:0000410)1.62674349
165Postural instability (HP:0002172)1.61815392
166True hermaphroditism (HP:0010459)1.61719833
167Parakeratosis (HP:0001036)1.61489221
168Cutaneous syndactyly (HP:0012725)1.60612585
169Congenital hepatic fibrosis (HP:0002612)1.60358733
170Abnormality of the middle phalanges of the toes (HP:0010183)1.60125497
171Optic nerve hypoplasia (HP:0000609)1.59940257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK7.26153729
2MKNK25.50920905
3FRK4.63275305
4STK393.55826980
5PRKD33.41178139
6MKNK13.20600649
7ADRBK22.80415541
8MAP4K22.61394276
9WNK32.51874476
10ZAK2.36496016
11CASK2.11884609
12TLK12.10728235
13PDK32.04549944
14PDK42.04549944
15TAOK32.00324074
16ICK1.99118200
17WNK11.90286929
18NUAK11.90073397
19MAP2K71.77259156
20WNK41.74760114
21OXSR11.65756298
22ACVR1B1.65240556
23PDK21.63751962
24DAPK21.58045713
25NTRK21.54792763
26TIE11.53382967
27EPHA41.46375990
28PHKG11.46349261
29PHKG21.46349261
30MUSK1.42326385
31RIPK11.41830564
32NEK61.41332781
33MAP3K41.37269415
34TRIM281.34768825
35MAPK131.34343754
36EPHB11.30007720
37INSRR1.27886743
38CAMKK21.26237003
39FGFR21.22372408
40NTRK31.21984160
41BCR1.18907658
42SGK2231.18903472
43SGK4941.18903472
44PRKCG1.14407783
45ADRBK11.11558978
46PINK11.09389003
47PNCK1.08721830
48PKN11.06142706
49CAMK1D1.05576240
50MAPKAPK51.04692541
51PTK2B1.04683572
52LMTK21.03839840
53TESK11.01503801
54DYRK21.00397900
55CAMK1G0.99798756
56SGK20.92089803
57BMPR1B0.91036516
58NTRK10.88936579
59MARK10.88884198
60PIK3CA0.84777001
61MAPKAPK30.84499581
62GRK70.83899863
63AKT30.80137682
64NEK20.78989821
65PRKCI0.78630580
66MST1R0.77519815
67MELK0.77506905
68CAMK10.73614946
69SGK30.73002178
70PRKCE0.70919169
71CAMK2A0.67777800
72MAPK150.66129831
73TXK0.63531291
74MAP2K40.62769710
75PAK60.62521698
76PLK40.61989456
77MINK10.61471752
78TGFBR10.61461479
79SGK10.60272677
80FGR0.59942044
81MET0.59228879
82PLK20.58349740
83STK30.57755907
84CDK50.57640848
85TYRO30.56345678
86MAP2K60.56137366
87CAMK2D0.55339098
88MAPK70.55331054
89PRPF4B0.54468574
90PDPK10.53932746
91MARK20.53657929
92BCKDK0.52650468
93CAMK2B0.52355542
94TSSK60.52131116
95CSNK1G20.52026668
96PRKACB0.51782777
97VRK10.50407504
98CSNK1A10.50397294
99PLK30.49820303
100ERBB20.48806639
101FER0.48486919
102CAMK2G0.47901868
103CDK30.47878052
104PDK10.47579700
105PAK30.46737934
106BRD40.46157707
107CAMK40.46138304
108MAPK120.45644506
109PRKCZ0.45045599
110GRK50.44226897
111PLK10.44048918
112MAP2K20.43605564
113CSNK1A1L0.43551555
114RPS6KA50.43235645
115ROCK20.42475472
116STK380.41852936
117MST40.41165455
118PRKAA10.40922781
119RPS6KB10.39931921
120UHMK10.39844070
121BRSK20.39235315
122LIMK10.38150495
123VRK20.36966860
124CSNK1D0.35770558
125CDK190.35762044
126OBSCN0.35439398
127PRKG10.34572089
128BMPR20.33672608
129GSK3B0.33564794
130PRKAA20.32853933
131EPHA20.32616929
132PRKCQ0.31890254
133MAPK100.31203432
134NME10.30698662
135MAP3K60.30262880
136CSNK1G30.28946458
137CSNK1G10.28313393
138PRKCH0.27888062
139GRK10.27510379
140PRKACA0.27292460
141RPS6KA30.26327690
142PRKCA0.26285839
143STK110.25877290
144PRKCB0.25867601
145STK38L0.25580713
146ROCK10.25473773

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.92793735
2Steroid biosynthesis_Homo sapiens_hsa001002.92739690
3Nitrogen metabolism_Homo sapiens_hsa009102.83049373
4Phototransduction_Homo sapiens_hsa047442.48217642
5Nicotine addiction_Homo sapiens_hsa050332.16792731
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11731834
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.05388983
8Glutamatergic synapse_Homo sapiens_hsa047241.98582193
9Ether lipid metabolism_Homo sapiens_hsa005651.96071466
10Selenocompound metabolism_Homo sapiens_hsa004501.87489853
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80942847
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80781313
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79605596
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.78669624
15Fatty acid elongation_Homo sapiens_hsa000621.77019368
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75290270
17Caffeine metabolism_Homo sapiens_hsa002321.73227023
18Dorso-ventral axis formation_Homo sapiens_hsa043201.73070244
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72112278
20GABAergic synapse_Homo sapiens_hsa047271.71065771
21Oxidative phosphorylation_Homo sapiens_hsa001901.70640395
22Circadian entrainment_Homo sapiens_hsa047131.64576777
23Basal transcription factors_Homo sapiens_hsa030221.58910135
24Tryptophan metabolism_Homo sapiens_hsa003801.56549766
25Protein export_Homo sapiens_hsa030601.52600225
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.52515588
27Fanconi anemia pathway_Homo sapiens_hsa034601.51251404
28Fatty acid metabolism_Homo sapiens_hsa012121.50055328
29Morphine addiction_Homo sapiens_hsa050321.48331530
30Insulin secretion_Homo sapiens_hsa049111.47651126
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46704717
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46006857
33Homologous recombination_Homo sapiens_hsa034401.44887478
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43516105
35Mineral absorption_Homo sapiens_hsa049781.40824613
36RNA polymerase_Homo sapiens_hsa030201.38841148
37Salivary secretion_Homo sapiens_hsa049701.38262564
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38141618
39Regulation of autophagy_Homo sapiens_hsa041401.37697928
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36561616
41Axon guidance_Homo sapiens_hsa043601.34722516
42Amphetamine addiction_Homo sapiens_hsa050311.34384674
43Taste transduction_Homo sapiens_hsa047421.33460181
44Gastric acid secretion_Homo sapiens_hsa049711.31547007
45Bile secretion_Homo sapiens_hsa049761.28580864
46Parkinsons disease_Homo sapiens_hsa050121.26633795
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24906603
48beta-Alanine metabolism_Homo sapiens_hsa004101.24409733
49Renin secretion_Homo sapiens_hsa049241.23934889
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21494472
51Long-term potentiation_Homo sapiens_hsa047201.19485126
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18131793
53Peroxisome_Homo sapiens_hsa041461.16771482
54RNA degradation_Homo sapiens_hsa030181.16194801
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15697398
56Linoleic acid metabolism_Homo sapiens_hsa005911.15273579
57Vitamin B6 metabolism_Homo sapiens_hsa007501.14636850
58Cocaine addiction_Homo sapiens_hsa050301.13993939
59Serotonergic synapse_Homo sapiens_hsa047261.13822358
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13746009
61Sulfur metabolism_Homo sapiens_hsa009201.13470516
62Propanoate metabolism_Homo sapiens_hsa006401.12507099
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.12322120
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10505237
65Olfactory transduction_Homo sapiens_hsa047401.09965552
66Long-term depression_Homo sapiens_hsa047301.06650993
67Calcium signaling pathway_Homo sapiens_hsa040201.06584318
68Chemical carcinogenesis_Homo sapiens_hsa052041.05354399
69Retinol metabolism_Homo sapiens_hsa008301.04715479
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02288575
71Pancreatic secretion_Homo sapiens_hsa049720.98545081
72PPAR signaling pathway_Homo sapiens_hsa033200.97720831
73Arginine and proline metabolism_Homo sapiens_hsa003300.95510404
74Arachidonic acid metabolism_Homo sapiens_hsa005900.95025596
75Sphingolipid metabolism_Homo sapiens_hsa006000.94823148
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.92527104
77Circadian rhythm_Homo sapiens_hsa047100.92518406
78Ovarian steroidogenesis_Homo sapiens_hsa049130.91602503
79Synaptic vesicle cycle_Homo sapiens_hsa047210.90522739
80cAMP signaling pathway_Homo sapiens_hsa040240.90392770
81Huntingtons disease_Homo sapiens_hsa050160.89907189
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88360214
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88002048
84Hedgehog signaling pathway_Homo sapiens_hsa043400.87073047
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85767056
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85267331
87Alzheimers disease_Homo sapiens_hsa050100.85173420
88Dopaminergic synapse_Homo sapiens_hsa047280.84500850
89Fat digestion and absorption_Homo sapiens_hsa049750.84138919
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83861179
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80570702
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80288907
93Cholinergic synapse_Homo sapiens_hsa047250.78721553
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.78022309
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.77572116
96Cardiac muscle contraction_Homo sapiens_hsa042600.76219055
97Fatty acid degradation_Homo sapiens_hsa000710.74287024
98Wnt signaling pathway_Homo sapiens_hsa043100.74090268
99Basal cell carcinoma_Homo sapiens_hsa052170.73748679
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73728782
101Melanogenesis_Homo sapiens_hsa049160.72951126
102Metabolic pathways_Homo sapiens_hsa011000.72135610
103Glycerolipid metabolism_Homo sapiens_hsa005610.71465122
104ErbB signaling pathway_Homo sapiens_hsa040120.69828862
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69605412
106Glucagon signaling pathway_Homo sapiens_hsa049220.69221193
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69021647
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67599473
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66792042
110Dilated cardiomyopathy_Homo sapiens_hsa054140.66634619
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66469478
112Ras signaling pathway_Homo sapiens_hsa040140.66387838
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66345792
114One carbon pool by folate_Homo sapiens_hsa006700.66037691
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.63807657
116Collecting duct acid secretion_Homo sapiens_hsa049660.63109481
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61832526
118Purine metabolism_Homo sapiens_hsa002300.61072951
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59253007
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.57235475
121Choline metabolism in cancer_Homo sapiens_hsa052310.56949627
122Butanoate metabolism_Homo sapiens_hsa006500.56288868
123Proteasome_Homo sapiens_hsa030500.55512367
124Sulfur relay system_Homo sapiens_hsa041220.55429733
125MAPK signaling pathway_Homo sapiens_hsa040100.54745577
126Oxytocin signaling pathway_Homo sapiens_hsa049210.54700799
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52752542
128Thyroid hormone synthesis_Homo sapiens_hsa049180.51638688
129Tight junction_Homo sapiens_hsa045300.50851394
130Gap junction_Homo sapiens_hsa045400.49897764
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49626005
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49333853
133Vitamin digestion and absorption_Homo sapiens_hsa049770.49283557
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48537302
135Rap1 signaling pathway_Homo sapiens_hsa040150.48113573
136Estrogen signaling pathway_Homo sapiens_hsa049150.47975001
137Autoimmune thyroid disease_Homo sapiens_hsa053200.47540109
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47488222
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44430603
140Pyrimidine metabolism_Homo sapiens_hsa002400.44311930
141Histidine metabolism_Homo sapiens_hsa003400.44199598
142ABC transporters_Homo sapiens_hsa020100.43459652
143GnRH signaling pathway_Homo sapiens_hsa049120.42429658
144Melanoma_Homo sapiens_hsa052180.42060743
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41107337
146Pyruvate metabolism_Homo sapiens_hsa006200.40215150
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39721574
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39684376
149Inositol phosphate metabolism_Homo sapiens_hsa005620.39386496
150Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38392634

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