TMCO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.82421310
2epithelial cilium movement (GO:0003351)9.73694757
3axonemal dynein complex assembly (GO:0070286)9.68159184
4reproduction (GO:0000003)9.61355909
5motile cilium assembly (GO:0044458)9.38020882
6response to pheromone (GO:0019236)9.13478619
7cilium or flagellum-dependent cell motility (GO:0001539)8.81111784
8regulation of cilium movement (GO:0003352)8.45235072
9cilium movement (GO:0003341)7.85749042
10single fertilization (GO:0007338)7.45938558
11protein targeting to Golgi (GO:0000042)7.38873064
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.29397103
13sperm capacitation (GO:0048240)7.23885489
14establishment of protein localization to Golgi (GO:0072600)7.20261516
15negative regulation of inclusion body assembly (GO:0090084)7.14504643
16synaptonemal complex organization (GO:0070193)7.10736312
17synaptonemal complex assembly (GO:0007130)7.03242746
18male meiosis (GO:0007140)6.97880969
19retrograde transport, vesicle recycling within Golgi (GO:0000301)6.82893212
20piRNA metabolic process (GO:0034587)6.77969257
21spermatogenesis (GO:0007283)6.75969638
22male gamete generation (GO:0048232)6.73523509
23microtubule depolymerization (GO:0007019)6.72432009
24rRNA methylation (GO:0031167)6.72008146
25organic cation transport (GO:0015695)6.52905631
26centriole replication (GO:0007099)6.50043702
27fertilization (GO:0009566)6.29002942
28gamete generation (GO:0007276)6.19448294
29phosphatidylethanolamine biosynthetic process (GO:0006646)5.98145337
30regulation of inclusion body assembly (GO:0090083)5.97579552
31rRNA modification (GO:0000154)5.75266659
32calcium ion-dependent exocytosis (GO:0017156)5.62270256
33phosphatidylethanolamine metabolic process (GO:0046337)5.61836507
34protein localization to Golgi apparatus (GO:0034067)5.52649939
35spermatid nucleus differentiation (GO:0007289)5.44057805
36germ cell development (GO:0007281)5.42913431
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.39459407
38chromosome condensation (GO:0030261)5.36624980
39cellular ketone body metabolic process (GO:0046950)5.17947733
40glycerol ether metabolic process (GO:0006662)5.09248360
41cell recognition (GO:0008037)5.08980931
42DNA packaging (GO:0006323)5.05206333
43regulation of centriole replication (GO:0046599)5.00667410
44ventricular system development (GO:0021591)4.99167495
45regulation of Rab GTPase activity (GO:0032313)4.98294750
46positive regulation of Rab GTPase activity (GO:0032851)4.98294750
47regulation of microtubule-based movement (GO:0060632)4.97472570
48multicellular organismal reproductive process (GO:0048609)4.87039210
49chromosome organization involved in meiosis (GO:0070192)4.79099072
50microtubule severing (GO:0051013)4.75001110
51ether metabolic process (GO:0018904)4.70700496
52male meiosis I (GO:0007141)4.68130291
53ketone body metabolic process (GO:1902224)4.57294721
54seminiferous tubule development (GO:0072520)4.56366149
55sexual reproduction (GO:0019953)4.43295209
56DNA methylation involved in gamete generation (GO:0043046)4.39589996
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32838091
58single strand break repair (GO:0000012)4.27920331
59chaperone-mediated protein complex assembly (GO:0051131)4.20214272
60meiotic nuclear division (GO:0007126)4.20115597
61regulation of transcription involved in cell fate commitment (GO:0060850)4.11524097
62left/right pattern formation (GO:0060972)4.07136687
63multicellular organismal movement (GO:0050879)4.03875457
64musculoskeletal movement (GO:0050881)4.03875457
65multicellular organismal development (GO:0007275)3.91459471
66meiosis I (GO:0007127)3.78093627
67microtubule nucleation (GO:0007020)3.76423263
68negative regulation of Rho protein signal transduction (GO:0035024)3.72535431
69coenzyme catabolic process (GO:0009109)3.64958687
70sequestering of actin monomers (GO:0042989)3.64915640
71protein K11-linked deubiquitination (GO:0035871)3.56424669
72genitalia morphogenesis (GO:0035112)3.50976006
73monoubiquitinated protein deubiquitination (GO:0035520)3.50750767
74microtubule polymerization or depolymerization (GO:0031109)3.47364603
75protein polyglutamylation (GO:0018095)3.46733438
76glomerular visceral epithelial cell development (GO:0072015)3.41609979
77regulation of spindle checkpoint (GO:0090231)3.38569697
78cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.35467787
79meiotic cell cycle (GO:0051321)3.25407735
80glomerular epithelial cell development (GO:0072310)3.23731592
81protein refolding (GO:0042026)3.23130000
82glycolytic process (GO:0006096)3.15309366
83nucleus organization (GO:0006997)3.14895728
84nucleoside diphosphate phosphorylation (GO:0006165)3.08114162
85polyol catabolic process (GO:0046174)3.06836452
86amino-acid betaine transport (GO:0015838)3.05540427
87carnitine transport (GO:0015879)3.05540427
88peptidyl-threonine dephosphorylation (GO:0035970)3.02808499
89protein localization to cilium (GO:0061512)3.02032960
90mitotic sister chromatid cohesion (GO:0007064)3.01991626
91positive regulation of macrophage activation (GO:0043032)2.99383489
92alditol metabolic process (GO:0019400)2.98192698
93spinal cord motor neuron differentiation (GO:0021522)2.98118241
94interferon-gamma secretion (GO:0072643)2.96813035
95cerebral cortex neuron differentiation (GO:0021895)2.95249179
96GTP biosynthetic process (GO:0006183)2.93481003
97NAD biosynthetic process (GO:0009435)2.90543429
98carnitine transmembrane transport (GO:1902603)2.88392798
99detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.84627256
100negative regulation of gene expression, epigenetic (GO:0045814)2.82324233
101membrane protein intracellular domain proteolysis (GO:0031293)2.81302018
102intra-Golgi vesicle-mediated transport (GO:0006891)2.80627055
103meiotic cell cycle process (GO:1903046)2.79952367
104synapsis (GO:0007129)2.79610267
105polyamine biosynthetic process (GO:0006596)2.78815643
106positive regulation of guanylate cyclase activity (GO:0031284)2.76300954
107cilium organization (GO:0044782)2.73315300
108regulation of interleukin-13 production (GO:0032656)2.71560343
109RNA localization (GO:0006403)2.69199175
110chromatin silencing (GO:0006342)2.67344506
111peptidyl-glutamic acid modification (GO:0018200)2.67010724
112mitochondrial fission (GO:0000266)2.66989825
113left/right axis specification (GO:0070986)2.66736598
114cellular response to pH (GO:0071467)2.66725677
115microtubule-based movement (GO:0007018)2.66565993
116cellular component assembly involved in morphogenesis (GO:0010927)2.64239853
117pattern specification involved in kidney development (GO:0061004)2.64185952
118cranial nerve morphogenesis (GO:0021602)2.63647511
119response to acidic pH (GO:0010447)2.63475752
120cilium assembly (GO:0042384)2.62500803
121UTP biosynthetic process (GO:0006228)2.62268424
122regulation of meiosis I (GO:0060631)2.62196991
123cilium morphogenesis (GO:0060271)2.61759720
124protein depolymerization (GO:0051261)2.60739068
125regulation of cilium assembly (GO:1902017)2.58370452
126RNA destabilization (GO:0050779)2.58192121
127intraciliary transport (GO:0042073)2.54875337
128lactate metabolic process (GO:0006089)2.54659296
129axoneme assembly (GO:0035082)2.53483022
130glycerol metabolic process (GO:0006071)2.49073534
131centriole assembly (GO:0098534)2.45436539
132negative regulation of organelle assembly (GO:1902116)2.40624200
133gene silencing by RNA (GO:0031047)2.40601523
134sperm motility (GO:0030317)14.0657076
135cell wall macromolecule catabolic process (GO:0016998)13.8240570
136cell wall macromolecule metabolic process (GO:0044036)13.8240570
137fusion of sperm to egg plasma membrane (GO:0007342)13.5911669
138acrosome reaction (GO:0007340)12.1773573
139acrosome assembly (GO:0001675)12.0560877
140sperm-egg recognition (GO:0035036)11.7603758
141multicellular organism reproduction (GO:0032504)11.0937325
142binding of sperm to zona pellucida (GO:0007339)10.6577332
143cell-cell recognition (GO:0009988)10.5267549
144plasma membrane fusion (GO:0045026)10.3538069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.50411989
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.13544291
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.12662202
4EZH2_22144423_ChIP-Seq_EOC_Human3.89710222
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.49994812
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15051168
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08518503
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.92284528
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85503130
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.62883813
11VDR_22108803_ChIP-Seq_LS180_Human2.45003270
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33057507
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.26846260
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18872467
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.15840883
16FUS_26573619_Chip-Seq_HEK293_Human2.14342413
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.13124733
18ERA_21632823_ChIP-Seq_H3396_Human2.07126848
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06199258
20KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.91736388
21RAC3_21632823_ChIP-Seq_H3396_Human1.90823399
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86480438
23ER_23166858_ChIP-Seq_MCF-7_Human1.86372091
24NANOG_20526341_ChIP-Seq_ESCs_Human1.86235650
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83766319
26RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.81312983
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80309128
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.80295509
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.78495958
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.76887825
31STAT1_17558387_ChIP-Seq_HELA_Human1.76558789
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.75303248
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74233950
34DROSHA_22980978_ChIP-Seq_HELA_Human1.73133205
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72806621
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71734040
37* MYC_19829295_ChIP-Seq_ESCs_Human1.71120836
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66737478
39GATA3_21867929_ChIP-Seq_CD8_Mouse1.63301887
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.61813563
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.60760219
42* TAF2_19829295_ChIP-Seq_ESCs_Human1.60307562
43* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.60106305
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.60050951
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.59926088
46CTCF_27219007_Chip-Seq_Bcells_Human1.59892387
47SMAD4_21741376_ChIP-Seq_EPCs_Human1.59085966
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56645825
49OCT4_20526341_ChIP-Seq_ESCs_Human1.56054593
50P300_19829295_ChIP-Seq_ESCs_Human1.54813124
51* E2F1_20622854_ChIP-Seq_HELA_Human1.51811002
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.51274827
53KDM2B_26808549_Chip-Seq_REH_Human1.50381179
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48871938
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.48502531
56CTCF_20526341_ChIP-Seq_ESCs_Human1.48144269
57* BCL6_27268052_Chip-Seq_Bcells_Human1.48036823
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.47664629
59AR_25329375_ChIP-Seq_VCAP_Human1.44552659
60P68_20966046_ChIP-Seq_HELA_Human1.41084910
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40621436
62CBP_20019798_ChIP-Seq_JUKART_Human1.40621436
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40346165
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38149040
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37946135
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37523690
67* PHF8_20622854_ChIP-Seq_HELA_Human1.37091706
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36790304
69TP53_18474530_ChIP-ChIP_U2OS_Human1.35686459
70AR_21572438_ChIP-Seq_LNCaP_Human1.34907299
71SMC4_20622854_ChIP-Seq_HELA_Human1.34169650
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.33830267
73* WDR5_24793694_ChIP-Seq_LNCAP_Human1.33463304
74SMAD3_21741376_ChIP-Seq_ESCs_Human1.33427176
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.32896445
76* ZNF274_21170338_ChIP-Seq_K562_Hela1.32816752
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32036137
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.31479070
79* BCOR_27268052_Chip-Seq_Bcells_Human1.31321899
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.30707128
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29411147
82HOXB7_26014856_ChIP-Seq_BT474_Human1.29294323
83REST_21632747_ChIP-Seq_MESCs_Mouse1.29058079
84TP63_22573176_ChIP-Seq_HFKS_Human1.28413776
85* P53_21459846_ChIP-Seq_SAOS-2_Human1.28138262
86P300_27268052_Chip-Seq_Bcells_Human1.27906217
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27743783
88CEBPB_22108803_ChIP-Seq_LS180_Human1.27670198
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27031712
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.26334165
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.25991633
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25548916
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25195619
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25028477
95GF1_26923725_Chip-Seq_HPCs_Mouse1.23930116
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23811586
97* HNFA_21074721_ChIP-Seq_CACO-2_Human1.23603503
98NANOG_19829295_ChIP-Seq_ESCs_Human1.23499795
99SOX2_19829295_ChIP-Seq_ESCs_Human1.23499795
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22444090
101* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20870219
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20867619
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20490289
104* RBPJ_21746931_ChIP-Seq_IB4_Human1.20432977
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19917844
106NCOR_22424771_ChIP-Seq_293T_Human1.18822475
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18704680
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18609063
109RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18279380
110FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17187534
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.17187534
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15862372
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15862152
114SPI1_26923725_Chip-Seq_HPCs_Mouse1.15364712
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.15338317
116STAT3_23295773_ChIP-Seq_U87_Human1.15202009
117* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15093914
118* ETV1_20927104_ChIP-Seq_GIST48_Human1.14724100
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14663866
120RUNX2_22187159_ChIP-Seq_PCA_Human1.13287122
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13166112
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.13150400
123FOXH1_21741376_ChIP-Seq_ESCs_Human1.12411714
124P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.12119629
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11091746
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11091746
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11083676
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10624142
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.10532213
130SMRT_27268052_Chip-Seq_Bcells_Human1.10272290
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10004378
132* NFYB_21822215_ChIP-Seq_K562_Human1.08248997
133RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07388767
134ERG_20517297_ChIP-Seq_VCAP_Human1.07004995
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06216552
136* TBL1_22424771_ChIP-Seq_293T_Human1.06145455
137ESET_19884257_ChIP-Seq_ESCs_Mouse1.06021812
138* PHF8_20622853_ChIP-Seq_HELA_Human1.05959531
139SMAD4_21741376_ChIP-Seq_HESCs_Human1.05861576
140SMAD4_21799915_ChIP-Seq_A2780_Human1.05542182
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04609794
142RARA_24833708_ChIP-Seq_LIVER_Mouse1.04002888
143OCT4_18555785_Chip-Seq_ESCs_Mouse1.03103019
144GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03068984
145TAF15_26573619_Chip-Seq_HEK293_Human1.02940198
146FOXH1_21741376_ChIP-Seq_EPCs_Human1.02906323
147MYC_27129775_Chip-Seq_CORNEA_Mouse1.02760917
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02259209
149GBX2_23144817_ChIP-Seq_PC3_Human1.01305919
150EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01248870
151YY1_22570637_ChIP-Seq_MALME-3M_Human1.01193462
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01138483
153LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00409805
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00048141
155TET1_21451524_ChIP-Seq_MESCs_Mouse0.99967759
156P53_22387025_ChIP-Seq_ESCs_Mouse0.99903380
157JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99473933
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98864469
159SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97795498
160ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97744713
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.96984966
162PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96583537
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96444207
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96319174
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.95244734
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94238481
167OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93091429
168KLF4_18555785_Chip-Seq_ESCs_Mouse0.92878401
169RNF2_27304074_Chip-Seq_NSC_Mouse0.92526401
170P300_18555785_Chip-Seq_ESCs_Mouse0.92231836
171KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91609525
172SOX9_26525672_Chip-Seq_HEART_Mouse0.90328245
173SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89922525
174ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89614654
175GF1B_26923725_Chip-Seq_HPCs_Mouse0.88791262
176EZH2_27294783_Chip-Seq_NPCs_Mouse0.88693133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.10929246
2MP0001929_abnormal_gametogenesis5.60547980
3MP0008877_abnormal_DNA_methylation4.06547860
4MP0002210_abnormal_sex_determination3.40204420
5MP0002161_abnormal_fertility/fecundity3.33828850
6MP0001348_abnormal_lacrimal_gland3.17552732
7MP0005670_abnormal_white_adipose2.89249848
8MP0001145_abnormal_male_reproductive2.88861917
9MP0000653_abnormal_sex_gland2.50620824
10MP0002653_abnormal_ependyma_morphology2.31709243
11MP0005423_abnormal_somatic_nervous2.17675821
12MP0003718_maternal_effect2.09167343
13MP0005410_abnormal_fertilization16.6326914
14MP0002837_dystrophic_cardiac_calcinosis1.90324055
15MP0005379_endocrine/exocrine_gland_phen1.89712158
16MP0001486_abnormal_startle_reflex1.67659436
17MP0000678_abnormal_parathyroid_gland1.67223438
18MP0003136_yellow_coat_color1.61352683
19MP0002160_abnormal_reproductive_system1.51349687
20MP0004233_abnormal_muscle_weight1.47345844
21MP0005310_abnormal_salivary_gland1.46044124
22MP0001485_abnormal_pinna_reflex1.44971319
23MP0002735_abnormal_chemical_nociception1.43561062
24MP0003646_muscle_fatigue1.42666942
25MP0002138_abnormal_hepatobiliary_system1.40830893
26MP0005623_abnormal_meninges_morphology1.31137623
27MP0005171_absent_coat_pigmentation1.18979462
28MP0002254_reproductive_system_inflammat1.16978592
29MP0002282_abnormal_trachea_morphology1.12587361
30MP0001765_abnormal_ion_homeostasis1.11081546
31MP0005395_other_phenotype1.10252776
32MP0001963_abnormal_hearing_physiology1.08912460
33MP0001986_abnormal_taste_sensitivity1.07673449
34MP0005083_abnormal_biliary_tract1.04904846
35MP0002249_abnormal_larynx_morphology1.02364641
36MP0000026_abnormal_inner_ear1.02327217
37MP0001984_abnormal_olfaction1.02200838
38MP0008058_abnormal_DNA_repair0.99740486
39MP0005167_abnormal_blood-brain_barrier0.95036804
40MP0002234_abnormal_pharynx_morphology0.94270422
41MP0002733_abnormal_thermal_nociception0.93440018
42MP0005647_abnormal_sex_gland0.91349010
43MP0002272_abnormal_nervous_system0.89982395
44MP0001905_abnormal_dopamine_level0.87824532
45MP0002572_abnormal_emotion/affect_behav0.85716869
46MP0004859_abnormal_synaptic_plasticity0.85327183
47MP0000955_abnormal_spinal_cord0.83236433
48MP0002067_abnormal_sensory_capabilities0.83031118
49MP0008789_abnormal_olfactory_epithelium0.82755195
50MP0009046_muscle_twitch0.82104145
51MP0009745_abnormal_behavioral_response0.82028088
52MP0001970_abnormal_pain_threshold0.82004186
53MP0001501_abnormal_sleep_pattern0.81601246
54MP0009053_abnormal_anal_canal0.80379671
55MP0006292_abnormal_olfactory_placode0.79662746
56MP0003137_abnormal_impulse_conducting0.79558069
57MP0005389_reproductive_system_phenotype0.75612456
58MP0000681_abnormal_thyroid_gland0.75271659
59MP0008995_early_reproductive_senescence0.74685843
60MP0002557_abnormal_social/conspecific_i0.74292447
61MP0004085_abnormal_heartbeat0.71597376
62MP0000230_abnormal_systemic_arterial0.68186451
63MP0005084_abnormal_gallbladder_morpholo0.67746700
64MP0003011_delayed_dark_adaptation0.67306170
65MP0003115_abnormal_respiratory_system0.66535389
66MP0006276_abnormal_autonomic_nervous0.63763165
67MP0005636_abnormal_mineral_homeostasis0.63607228
68MP0002127_abnormal_cardiovascular_syste0.60991875
69MP0003787_abnormal_imprinting0.60511165
70MP0010094_abnormal_chromosome_stability0.59926530
71MP0005377_hearing/vestibular/ear_phenot0.59568902
72MP0003878_abnormal_ear_physiology0.59568902
73MP0006072_abnormal_retinal_apoptosis0.58866246
74MP0004484_altered_response_of0.58514006
75MP0005332_abnormal_amino_acid0.56887977
76MP0010329_abnormal_lipoprotein_level0.55401584
77MP0001440_abnormal_grooming_behavior0.55035725
78MP0003880_abnormal_central_pattern0.54885288
79MP0004510_myositis0.54816632
80MP0000049_abnormal_middle_ear0.54682431
81MP0005666_abnormal_adipose_tissue0.53438572
82MP0008569_lethality_at_weaning0.53186517
83MP0002168_other_aberrant_phenotype0.53120611
84MP0002734_abnormal_mechanical_nocicepti0.52501478
85MP0004036_abnormal_muscle_relaxation0.52260129
86MP0001764_abnormal_homeostasis0.51222197
87MP0002822_catalepsy0.50653956
88MP0003045_fibrosis0.50618409
89MP0003635_abnormal_synaptic_transmissio0.50073125
90MP0001324_abnormal_eye_pigmentation0.49509797
91MP0001666_abnormal_nutrient_absorption0.49263693
92MP0005499_abnormal_olfactory_system0.49157210
93MP0005394_taste/olfaction_phenotype0.49157210
94MP0003699_abnormal_female_reproductive0.48988187
95MP0005535_abnormal_body_temperature0.48925242
96MP0003329_amyloid_beta_deposits0.48504530
97MP0002876_abnormal_thyroid_physiology0.48366843
98MP0001293_anophthalmia0.48207624
99MP0005085_abnormal_gallbladder_physiolo0.47596449
100MP0000358_abnormal_cell_content/0.47302266
101MP0005248_abnormal_Harderian_gland0.46919528
102MP0009764_decreased_sensitivity_to0.46782846
103MP0002269_muscular_atrophy0.46068542
104MP0002736_abnormal_nociception_after0.45762802
105MP0001270_distended_abdomen0.45637844
106MP0005174_abnormal_tail_pigmentation0.45354937
107MP0005397_hematopoietic_system_phenotyp0.43841651
108MP0001545_abnormal_hematopoietic_system0.43841651
109MP0003111_abnormal_nucleus_morphology0.41975563
110MP0006036_abnormal_mitochondrial_physio0.40346963
111MP0002928_abnormal_bile_duct0.38637062
112MP0005253_abnormal_eye_physiology0.37963117
113MP0000569_abnormal_digit_pigmentation0.37824489
114MP0009115_abnormal_fat_cell0.37769036
115MP0002102_abnormal_ear_morphology0.37405933
116MP0005551_abnormal_eye_electrophysiolog0.37100379
117MP0009278_abnormal_bone_marrow0.36028736
118MP0003950_abnormal_plasma_membrane0.35752423
119MP0000534_abnormal_ureter_morphology0.33625522
120MP0001730_embryonic_growth_arrest0.32186690
121MP0001119_abnormal_female_reproductive0.30467888
122MP0003786_premature_aging0.29936496
123MP0000604_amyloidosis0.29812851
124MP0004133_heterotaxia0.29501470
125MP0005391_vision/eye_phenotype0.29486920
126MP0008057_abnormal_DNA_replication0.28003774
127MP0004019_abnormal_vitamin_homeostasis0.27776528
128MP0002971_abnormal_brown_adipose0.27665751
129MP0002139_abnormal_hepatobiliary_system0.27219973
130MP0003633_abnormal_nervous_system0.26876253
131MP0010307_abnormal_tumor_latency0.26585027
132MP0004811_abnormal_neuron_physiology0.24730775
133MP0001968_abnormal_touch/_nociception0.23910987
134MP0008007_abnormal_cellular_replicative0.23900528
135MP0002169_no_abnormal_phenotype0.23426141
136MP0002873_normal_phenotype0.23183989
137MP0003861_abnormal_nervous_system0.22948645
138MP0003942_abnormal_urinary_system0.22027273
139MP0003879_abnormal_hair_cell0.21930756
140MP0006035_abnormal_mitochondrial_morpho0.21397444
141MP0002132_abnormal_respiratory_system0.20419276
142MP0003631_nervous_system_phenotype0.20343128
143MP0003948_abnormal_gas_homeostasis0.19761110
144MP0002152_abnormal_brain_morphology0.19610995
145MP0001661_extended_life_span0.17188021
146MP0004742_abnormal_vestibular_system0.16992130
147MP0000313_abnormal_cell_death0.16708530
148MP0001849_ear_inflammation0.16609714
149MP0004145_abnormal_muscle_electrophysio0.15576064
150MP0002092_abnormal_eye_morphology0.15553687
151MP0005319_abnormal_enzyme/_coenzyme0.15060891
152MP0002084_abnormal_developmental_patter0.14971093
153MP0001727_abnormal_embryo_implantation0.14946955
154MP0005365_abnormal_bile_salt0.14913153
155MP0000001_mammalian_phenotype0.14801715
156MP0001672_abnormal_embryogenesis/_devel0.14580876
157MP0005380_embryogenesis_phenotype0.14580876
158MP0002295_abnormal_pulmonary_circulatio0.14497013
159MP0005375_adipose_tissue_phenotype0.13068928
160MP0008875_abnormal_xenobiotic_pharmacok0.12827852
161MP0002693_abnormal_pancreas_physiology0.12711003
162MP0004043_abnormal_pH_regulation0.12637678
163MP0004808_abnormal_hematopoietic_stem0.12423184
164MP0004084_abnormal_cardiac_muscle0.12122370
165MP0002229_neurodegeneration0.11974745
166MP0001697_abnormal_embryo_size0.11917699
167MP0002405_respiratory_system_inflammati0.11851246

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.46310987
2Abnormal respiratory motile cilium morphology (HP:0005938)9.36558067
3Abnormal respiratory epithelium morphology (HP:0012253)9.36558067
4Abnormal ciliary motility (HP:0012262)7.53053149
5Rhinitis (HP:0012384)7.52780272
6Chronic bronchitis (HP:0004469)7.46684828
7Severe visual impairment (HP:0001141)7.33669305
8Infertility (HP:0000789)6.95145971
9Nasal polyposis (HP:0100582)6.40820571
10Attenuation of retinal blood vessels (HP:0007843)5.50292143
11Abnormality of the nasal mucosa (HP:0000433)5.26134189
12Chronic hepatic failure (HP:0100626)5.22689060
13Bony spicule pigmentary retinopathy (HP:0007737)4.89069478
14Male infertility (HP:0003251)4.85716212
15Bronchitis (HP:0012387)4.58872195
16Bronchiectasis (HP:0002110)4.41216010
17Abnormal rod and cone electroretinograms (HP:0008323)4.15943088
18Amelogenesis imperfecta (HP:0000705)4.14482490
19Abnormality of macular pigmentation (HP:0008002)4.10243214
20Nephronophthisis (HP:0000090)3.99298428
21Hyperkalemia (HP:0002153)3.89885531
22Abnormal spermatogenesis (HP:0008669)3.73570404
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.64172510
24Facial shape deformation (HP:0011334)3.63971201
25Potter facies (HP:0002009)3.63971201
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.53511691
27Resting tremor (HP:0002322)3.45462976
28Recurrent sinusitis (HP:0011108)3.42394221
29Cone-rod dystrophy (HP:0000548)3.33844041
30Recurrent otitis media (HP:0000403)3.29096389
31Hypoplastic ischia (HP:0003175)3.12003890
32Enlarged epiphyses (HP:0010580)3.08223931
33Abnormality of the renal medulla (HP:0100957)2.98856576
34Abnormality of dental color (HP:0011073)2.87134921
35Hypoplasia of the thymus (HP:0000778)2.83322646
36Impulsivity (HP:0100710)2.69643618
37Tubulointerstitial nephritis (HP:0001970)2.69286266
38Progressive cerebellar ataxia (HP:0002073)2.68936167
39Polyuria (HP:0000103)2.68847844
40Abnormality of the aortic arch (HP:0012303)2.67730020
41Recurrent bronchitis (HP:0002837)2.66997106
42Abnormality of the ischium (HP:0003174)2.66902456
43Portal hypertension (HP:0001409)2.66155581
44Postural instability (HP:0002172)2.65838786
45Hypoalphalipoproteinemia (HP:0003233)2.58161642
46Abnormality of the hepatic vasculature (HP:0006707)2.57287596
47Molar tooth sign on MRI (HP:0002419)2.55827490
48Abnormality of midbrain morphology (HP:0002418)2.55827490
49Medial flaring of the eyebrow (HP:0010747)2.55744027
50Pendular nystagmus (HP:0012043)2.51333949
51Tubular atrophy (HP:0000092)2.49173448
52Abnormality of potassium homeostasis (HP:0011042)2.48293413
53Abnormality of the costochondral junction (HP:0000919)2.41382161
54Azoospermia (HP:0000027)2.38796211
55Pancreatic cysts (HP:0001737)2.36629095
56Generalized aminoaciduria (HP:0002909)2.34946767
57Type II lissencephaly (HP:0007260)2.32793163
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.32608722
59Tubulointerstitial abnormality (HP:0001969)2.32192658
60Progressive sensorineural hearing impairment (HP:0000408)2.25393321
61Congenital stationary night blindness (HP:0007642)2.24389260
62Gonadotropin excess (HP:0000837)2.23037331
63Cholecystitis (HP:0001082)2.18954916
64Abnormal gallbladder physiology (HP:0012438)2.18954916
65Insulin-resistant diabetes mellitus (HP:0000831)2.18649362
66Unilateral renal agenesis (HP:0000122)2.15389137
67Renal Fanconi syndrome (HP:0001994)2.14437421
68Truncal obesity (HP:0001956)2.13832528
69Photophobia (HP:0000613)2.08306420
70Dyschromatopsia (HP:0007641)2.05679212
71Renovascular hypertension (HP:0100817)2.03704268
72Menstrual irregularities (HP:0000858)2.03111518
73Absent/shortened dynein arms (HP:0200106)13.5852556
74Dynein arm defect of respiratory motile cilia (HP:0012255)13.5852556
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1645614
76Hypoalbuminemia (HP:0003073)1.97519245
77Abnormal albumin level (HP:0012116)1.97519245
78Congenital sensorineural hearing impairment (HP:0008527)1.96947950
79Tetany (HP:0001281)1.95146903
80Increased purine levels (HP:0004368)1.91936333
81Hyperuricemia (HP:0002149)1.91936333
82Optic nerve hypoplasia (HP:0000609)1.88717596
83Decreased central vision (HP:0007663)1.88712832
84Tubulointerstitial fibrosis (HP:0005576)1.88640599
85Abnormality of the parathyroid morphology (HP:0011766)1.87365094
86Spastic tetraparesis (HP:0001285)1.85305207
87Glycosuria (HP:0003076)1.85157919
88Abnormality of urine glucose concentration (HP:0011016)1.85157919
89Hypophosphatemic rickets (HP:0004912)1.84638785
90Abnormality of the epiphysis of the femoral head (HP:0010574)1.82992978
91Choroideremia (HP:0001139)1.82691343
92Muscle fiber atrophy (HP:0100295)1.81941682
93Type II diabetes mellitus (HP:0005978)1.81672545
94Flattened epiphyses (HP:0003071)1.80960406
95Horizontal nystagmus (HP:0000666)1.79526324
96Intellectual disability, moderate (HP:0002342)1.78860211
97Spastic paraparesis (HP:0002313)1.74981614
98Postaxial foot polydactyly (HP:0001830)1.74625659
99Macular degeneration (HP:0000608)1.74341891
100Stage 5 chronic kidney disease (HP:0003774)1.69207269
101Abnormal drinking behavior (HP:0030082)1.69117563
102Polydipsia (HP:0001959)1.69117563
103Congenital malformation of the right heart (HP:0011723)1.63442121
104Double outlet right ventricle (HP:0001719)1.63442121
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63267261
106Heterotopia (HP:0002282)1.63131542
107Congenital hepatic fibrosis (HP:0002612)1.62798184
108Abnormality of renal excretion (HP:0011036)1.60552114
109Hemorrhage of the eye (HP:0011885)1.60155203
110Abnormal biliary tract physiology (HP:0012439)1.56431414
111Bile duct proliferation (HP:0001408)1.56431414
112Abnormality of the renal cortex (HP:0011035)1.56278587
113Aplasia/Hypoplasia of the lens (HP:0008063)1.55127132
114Asymmetric septal hypertrophy (HP:0001670)1.48571204
115Short ribs (HP:0000773)1.47704470
116Congenital primary aphakia (HP:0007707)1.46603447
117Oculomotor apraxia (HP:0000657)1.46578131
118Gait imbalance (HP:0002141)1.46128875
119Abnormality of permanent molar morphology (HP:0011071)1.45637338
120Abnormality of the dental root (HP:0006486)1.45637338
121Taurodontia (HP:0000679)1.45637338
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.44429644
123Neurofibrillary tangles (HP:0002185)1.44177402
124Bundle branch block (HP:0011710)1.44041023
125Postaxial hand polydactyly (HP:0001162)1.41977122
126Bell-shaped thorax (HP:0001591)1.41506151
127Facial cleft (HP:0002006)1.40987331
128Chronic sinusitis (HP:0011109)1.40426283
129Fibular hypoplasia (HP:0003038)1.40382012
130Easy fatigability (HP:0003388)1.39463208
131Renal dysplasia (HP:0000110)1.37599635
132Abnormality of the dental pulp (HP:0006479)1.35421227
133Abnormality of molar (HP:0011077)1.34392687
134Abnormality of molar morphology (HP:0011070)1.34392687
135Abnormality of the lower motor neuron (HP:0002366)1.32905003
136Pancreatic fibrosis (HP:0100732)1.32318881
137Cystic liver disease (HP:0006706)1.32170687
138Fatigable weakness (HP:0003473)1.31307071
139Abnormality of the neuromuscular junction (HP:0003398)1.31307071
140Abnormal urine output (HP:0012590)1.31098476
141Abnormality of dentin (HP:0010299)1.29771917
142Constricted visual fields (HP:0001133)1.28969183
143Absent epiphyses (HP:0010577)1.27704682
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27704682
145Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.27146028
146Exercise-induced myalgia (HP:0003738)1.25617365
147Deformed sella turcica (HP:0002681)1.24001898
148Nephrogenic diabetes insipidus (HP:0009806)1.23110321
149Microglossia (HP:0000171)1.21560681
150Cerebellar dysplasia (HP:0007033)1.20531085
151Abnormality of saccadic eye movements (HP:0000570)1.20526801
152Amyotrophic lateral sclerosis (HP:0007354)1.18743995
153Sensory axonal neuropathy (HP:0003390)1.18623597
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.17592137
155Cerebral inclusion bodies (HP:0100314)1.16038165
156Vaginal atresia (HP:0000148)1.15847892
157Genital tract atresia (HP:0001827)1.15297684
158Myoglobinuria (HP:0002913)1.14490341
159Type 2 muscle fiber atrophy (HP:0003554)1.14236981
160Abnormality of ocular smooth pursuit (HP:0000617)1.13880439
161Nephropathy (HP:0000112)1.13586354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.40825259
2PDK38.40825259
3TESK16.07218863
4PDK25.45308213
5PRKD34.84839487
6ICK4.31959146
7INSRR4.00201903
8MAP4K23.92940864
9DDR23.46267652
10PLK23.19387530
11BRD43.13147468
12LATS12.22513127
13PTK2B2.17625717
14WNK42.08033399
15STK392.01847311
16PIK3CG2.00018440
17STK381.78592565
18PNCK1.75371711
19NEK21.63974878
20LATS21.54469521
21FRK1.52877679
22DYRK1B1.52156146
23ACVR1B1.29521511
24ZAK1.28965527
25PDK11.23424696
26MAP2K21.17364633
27ADRBK21.06403955
28BMPR1B1.05135656
29MST1R0.98832058
30DYRK30.96692656
31SIK20.92840393
32CDK70.89590541
33TYRO30.84903932
34IRAK10.80767138
35PDPK10.76997345
36RIPK40.76802088
37PRKAA20.75749570
38CCNB10.75538279
39MAPK150.74726696
40WNK10.73722994
41KSR20.72479162
42OXSR10.72030216
43MAP3K110.69115191
44MAP3K40.68505077
45TESK20.67617140
46PASK0.66607903
47STK30.65400792
48TAOK30.65009341
49AKT30.64471035
50CAMK1D0.64197967
51TXK0.63907801
52TTK0.63191772
53CHEK20.62877417
54MAP3K90.62541640
55GRK10.61822547
56PINK10.60582303
57EEF2K0.57292059
58MAP2K60.56266787
59TIE10.55949241
60RPS6KA20.55200183
61LMTK20.53428445
62STK38L0.53048899
63TLK10.49308762
64MARK10.48692724
65CAMK10.45748854
66CAMK1G0.42904672
67MUSK0.42409529
68WEE10.41510718
69CDK30.41280998
70IRAK20.41069495
71CHEK10.40994623
72PAK10.40554021
73PRKCG0.38666291
74PLK40.38433534
75NTRK20.37827538
76NTRK30.37101278
77BRSK20.35695095
78MAPK10.32635118
79RPS6KA60.31803100
80UHMK10.30676468
81MAP3K20.30507736
82ROCK10.29627988
83MAP3K100.27821496
84SGK2230.27340155
85SGK4940.27340155
86ATM0.27242450
87PAK20.26595403
88RPS6KC10.25972994
89RPS6KL10.25972994
90ATR0.25405724
91MAPKAPK50.24152370
92IKBKB0.24122372
93CAMK40.22112205
94MAP2K70.21940500
95MTOR0.21662045
96CAMKK10.21494820
97PLK10.21168001
98MARK20.20706925
99PAK40.20292535
100BCKDK0.20218505
101DAPK20.19973557
102NEK60.19726053
103BRSK10.19676789
104KIT0.19534119
105SGK10.18816833
106MAPK110.18386153
107PRKAA10.18084165
108PRKCE0.17778707
109PRKCZ0.17467411
110CDC70.17305981
111MAPK140.15735525
112CDK150.15588346
113DYRK20.15213100
114TEC0.14415439
115TNIK0.13925535
116ARAF0.13619932
117AKT10.13225454
118MAPK130.12959883
119CDK180.12787409
120RPS6KB10.12680784
121PRKCQ0.12111972
122CDK11A0.11813672
123MARK30.11541026
124BRAF0.10846379
125PRKG20.10223876
126CSNK2A10.09284598
127CDK140.08175573
128RPS6KA10.07182738
129CDK60.06316452
130GSK3B0.06101465
131CDK120.05630227
132STK100.05000187
133CSF1R0.04557098
134PRKCD0.04501585
135CDK20.04190912
136PRKG10.03930527
137BUB10.03804006
138PKN10.03734358
139CDK10.03690332
140PRKACG0.03676714
141CSNK2A20.03592277
142PIM10.03167195
143STK110.02709358
144AURKA0.02262150
145MAPK80.01806232
146CSNK1D0.01781058
147CAMK2A0.01353900
148PRKCB0.01194836
149ZAP700.00935182
150PRKCA0.00595595
151CDK40.00569331
152YES10.00082201
153PRKDC-0.0399269
154PRKACA-0.0343093
155RPS6KA3-0.0329000
156PRKACB-0.0273041
157MAP3K5-0.0265352
158PDGFRB-0.0147885
159EGFR-0.0077089
160WNK3-0.0032870

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.55696877
2Fatty acid biosynthesis_Homo sapiens_hsa000614.57766859
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.49146998
4Vitamin B6 metabolism_Homo sapiens_hsa007504.19117696
5Olfactory transduction_Homo sapiens_hsa047403.75634012
6Pyruvate metabolism_Homo sapiens_hsa006203.43592291
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.04960551
8Linoleic acid metabolism_Homo sapiens_hsa005912.96365076
9Propanoate metabolism_Homo sapiens_hsa006402.69313811
10Phototransduction_Homo sapiens_hsa047442.67820238
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.64137024
12Butanoate metabolism_Homo sapiens_hsa006502.64021420
13Glucagon signaling pathway_Homo sapiens_hsa049222.57213384
14Basal transcription factors_Homo sapiens_hsa030222.47732920
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25678777
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08080815
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98852283
18Selenocompound metabolism_Homo sapiens_hsa004501.96936392
19Type I diabetes mellitus_Homo sapiens_hsa049401.96337649
20Glycerolipid metabolism_Homo sapiens_hsa005611.95898058
21Allograft rejection_Homo sapiens_hsa053301.93879537
22Graft-versus-host disease_Homo sapiens_hsa053321.92782866
23Pentose phosphate pathway_Homo sapiens_hsa000301.92323547
24Nicotine addiction_Homo sapiens_hsa050331.90653178
25Autoimmune thyroid disease_Homo sapiens_hsa053201.89193427
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88222081
27PPAR signaling pathway_Homo sapiens_hsa033201.83578277
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.83515233
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.75233864
30Oocyte meiosis_Homo sapiens_hsa041141.72177371
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.64352803
32Phenylalanine metabolism_Homo sapiens_hsa003601.62705217
33Fructose and mannose metabolism_Homo sapiens_hsa000511.60642303
34Mineral absorption_Homo sapiens_hsa049781.53991372
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.50984373
36Amphetamine addiction_Homo sapiens_hsa050311.47069971
37Fat digestion and absorption_Homo sapiens_hsa049751.43709869
38Carbon metabolism_Homo sapiens_hsa012001.43620424
39Ether lipid metabolism_Homo sapiens_hsa005651.40780167
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37583899
41Type II diabetes mellitus_Homo sapiens_hsa049301.36507145
42Morphine addiction_Homo sapiens_hsa050321.34933631
43Fatty acid metabolism_Homo sapiens_hsa012121.34356609
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34224790
45Fatty acid degradation_Homo sapiens_hsa000711.32512039
46Fanconi anemia pathway_Homo sapiens_hsa034601.31548448
47Dorso-ventral axis formation_Homo sapiens_hsa043201.30569404
48Arginine and proline metabolism_Homo sapiens_hsa003301.28222814
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25274892
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.25168120
51Cardiac muscle contraction_Homo sapiens_hsa042601.24500333
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.24469582
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23587759
54Nitrogen metabolism_Homo sapiens_hsa009101.22520104
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.15012846
56Antigen processing and presentation_Homo sapiens_hsa046121.12393690
57Purine metabolism_Homo sapiens_hsa002301.12102813
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11298822
59Viral myocarditis_Homo sapiens_hsa054161.06051340
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04799969
61Renin secretion_Homo sapiens_hsa049241.02752752
62Collecting duct acid secretion_Homo sapiens_hsa049661.02472167
63Glutathione metabolism_Homo sapiens_hsa004801.02296685
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01944648
65Biosynthesis of amino acids_Homo sapiens_hsa012300.99686278
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98002797
67mRNA surveillance pathway_Homo sapiens_hsa030150.97492771
68RNA transport_Homo sapiens_hsa030130.95583180
69Glutamatergic synapse_Homo sapiens_hsa047240.94377936
70Huntingtons disease_Homo sapiens_hsa050160.93956444
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92651427
72Retinol metabolism_Homo sapiens_hsa008300.88543116
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84968591
74Hedgehog signaling pathway_Homo sapiens_hsa043400.84097640
75Chemical carcinogenesis_Homo sapiens_hsa052040.81299263
76Arachidonic acid metabolism_Homo sapiens_hsa005900.79880101
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79833901
78Tyrosine metabolism_Homo sapiens_hsa003500.78629562
79Sulfur relay system_Homo sapiens_hsa041220.77474974
80Insulin secretion_Homo sapiens_hsa049110.76061765
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.74834086
82Renin-angiotensin system_Homo sapiens_hsa046140.70775128
83Tryptophan metabolism_Homo sapiens_hsa003800.70617818
84GABAergic synapse_Homo sapiens_hsa047270.69052855
85Thyroid hormone synthesis_Homo sapiens_hsa049180.68796715
86Serotonergic synapse_Homo sapiens_hsa047260.68312224
87Bile secretion_Homo sapiens_hsa049760.67411154
88Long-term potentiation_Homo sapiens_hsa047200.66978403
89Estrogen signaling pathway_Homo sapiens_hsa049150.65771579
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64230573
91Legionellosis_Homo sapiens_hsa051340.63243894
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61892748
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61437545
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.60398211
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54082856
96Systemic lupus erythematosus_Homo sapiens_hsa053220.53631229
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51551562
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.51280163
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50907739
100Pancreatic secretion_Homo sapiens_hsa049720.50683822
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48836945
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.47462840
103Synaptic vesicle cycle_Homo sapiens_hsa047210.46633462
104Calcium signaling pathway_Homo sapiens_hsa040200.46311980
105Influenza A_Homo sapiens_hsa051640.46211130
106Sphingolipid metabolism_Homo sapiens_hsa006000.45464312
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45316068
108Protein digestion and absorption_Homo sapiens_hsa049740.44872007
109Salivary secretion_Homo sapiens_hsa049700.44182038
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44151625
111Pyrimidine metabolism_Homo sapiens_hsa002400.43084647
112Metabolic pathways_Homo sapiens_hsa011000.41326034
113Endocytosis_Homo sapiens_hsa041440.40734083
114Inositol phosphate metabolism_Homo sapiens_hsa005620.40721515
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40241553
116ABC transporters_Homo sapiens_hsa020100.40187870
117Arginine biosynthesis_Homo sapiens_hsa002200.39515357
118AMPK signaling pathway_Homo sapiens_hsa041520.39343123
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.36981307
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.36824818
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36067994
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36027923
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33791939
124Gastric acid secretion_Homo sapiens_hsa049710.33599854
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32351305
126Sulfur metabolism_Homo sapiens_hsa009200.32327993
127Cholinergic synapse_Homo sapiens_hsa047250.32139734
128beta-Alanine metabolism_Homo sapiens_hsa004100.29120941
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29084778
130VEGF signaling pathway_Homo sapiens_hsa043700.28400203
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27414695
132Peroxisome_Homo sapiens_hsa041460.27092273
133cAMP signaling pathway_Homo sapiens_hsa040240.25258460
134Taste transduction_Homo sapiens_hsa047420.25167769
135Asthma_Homo sapiens_hsa053100.24801975
136Alcoholism_Homo sapiens_hsa050340.20943088
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20553148
138Cocaine addiction_Homo sapiens_hsa050300.16297746
139Circadian entrainment_Homo sapiens_hsa047130.15931050
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10445767
141N-Glycan biosynthesis_Homo sapiens_hsa005100.09382181
142Salmonella infection_Homo sapiens_hsa051320.07932134
143HIF-1 signaling pathway_Homo sapiens_hsa040660.07838429
144B cell receptor signaling pathway_Homo sapiens_hsa046620.07336476
145Wnt signaling pathway_Homo sapiens_hsa043100.07290272
146Cell cycle_Homo sapiens_hsa041100.06233412
147Viral carcinogenesis_Homo sapiens_hsa052030.04511848

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