TMCO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.99095508
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.99095508
3antigen processing and presentation of endogenous antigen (GO:0019883)5.47111247
4positive regulation of gamma-delta T cell activation (GO:0046645)4.62894540
5regulation of gamma-delta T cell differentiation (GO:0045586)4.09991338
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75474919
7regulation of gamma-delta T cell activation (GO:0046643)3.70463082
8negative T cell selection (GO:0043383)3.48335926
9negative thymic T cell selection (GO:0045060)3.47417214
10positive thymic T cell selection (GO:0045059)3.35015759
11antigen processing and presentation via MHC class Ib (GO:0002475)3.28675966
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.27908675
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26335015
14valine metabolic process (GO:0006573)3.14185245
15mannose metabolic process (GO:0006013)3.12293722
16regulation of extracellular matrix disassembly (GO:0010715)3.09260240
17positive regulation of B cell differentiation (GO:0045579)3.04608208
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.02335233
19thymic T cell selection (GO:0045061)3.01617220
20regulation of interleukin-12 biosynthetic process (GO:0045075)2.97050305
21positive regulation of Cdc42 GTPase activity (GO:0043089)2.96884611
22regulation of type I interferon-mediated signaling pathway (GO:0060338)2.95535089
23response to peptidoglycan (GO:0032494)2.93536761
24regulation of response to interferon-gamma (GO:0060330)2.88655190
25positive regulation by symbiont of host defense response (GO:0052509)2.81618168
26modulation by symbiont of host defense response (GO:0052031)2.81618168
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81618168
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81618168
29positive regulation by organism of defense response of other organism involved in symbiotic interact2.81618168
30modulation by symbiont of host immune response (GO:0052553)2.81618168
31interferon-gamma production (GO:0032609)2.81457539
32regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.78922142
33NIK/NF-kappaB signaling (GO:0038061)2.78796827
34response to interleukin-15 (GO:0070672)2.78476484
35urea metabolic process (GO:0019627)2.77758103
36urea cycle (GO:0000050)2.77758103
37barbed-end actin filament capping (GO:0051016)2.77496559
38regulation of B cell receptor signaling pathway (GO:0050855)2.76621535
39response to type I interferon (GO:0034340)2.76194530
40kynurenine metabolic process (GO:0070189)2.74967399
41macrophage activation involved in immune response (GO:0002281)2.73954560
42regulation of interferon-beta biosynthetic process (GO:0045357)2.73923178
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73735986
44regulation of B cell differentiation (GO:0045577)2.73617357
45immunoglobulin mediated immune response (GO:0016064)2.72223475
46cellular response to type I interferon (GO:0071357)2.70559803
47type I interferon signaling pathway (GO:0060337)2.70559803
48tryptophan catabolic process (GO:0006569)2.69228384
49indole-containing compound catabolic process (GO:0042436)2.69228384
50indolalkylamine catabolic process (GO:0046218)2.69228384
51regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.69027146
52regulation of natural killer cell mediated immunity (GO:0002715)2.69027146
53ribosomal small subunit assembly (GO:0000028)2.66765037
54pinocytosis (GO:0006907)2.66720281
55JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66136922
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65330324
57negative regulation of cholesterol transport (GO:0032375)2.64385470
58negative regulation of sterol transport (GO:0032372)2.64385470
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63744825
60L-phenylalanine metabolic process (GO:0006558)2.63744825
61positive regulation of humoral immune response (GO:0002922)2.63548161
62leukocyte aggregation (GO:0070486)2.62724592
63phospholipid efflux (GO:0033700)2.61914055
64T cell selection (GO:0045058)2.61761930
65aromatic amino acid family catabolic process (GO:0009074)2.61531197
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.59416510
67regulation of regulatory T cell differentiation (GO:0045589)2.58734072
68T cell migration (GO:0072678)2.57601394
69regulation of alpha-beta T cell proliferation (GO:0046640)2.56651868
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.56603377
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55966924
72L-phenylalanine catabolic process (GO:0006559)2.55966924
73regulation of triglyceride catabolic process (GO:0010896)2.55633489
74regulation of necroptotic process (GO:0060544)2.54802388
75tryptophan metabolic process (GO:0006568)2.52966211
76Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52078118
77positive T cell selection (GO:0043368)2.51418328
78B cell mediated immunity (GO:0019724)2.50774855
79hypotonic response (GO:0006971)2.50687896
80nitrogen cycle metabolic process (GO:0071941)2.50238996
81negative regulation of type 2 immune response (GO:0002829)2.49960922
82glycine metabolic process (GO:0006544)2.49167121
83detection of bacterium (GO:0016045)2.48867116
84hepatocyte apoptotic process (GO:0097284)2.48525169
85regulation of tolerance induction (GO:0002643)2.46977445
86positive regulation of tolerance induction (GO:0002645)2.44983715
87negative regulation of innate immune response (GO:0045824)2.44983201
88amyloid precursor protein catabolic process (GO:0042987)2.44498128
89alpha-linolenic acid metabolic process (GO:0036109)2.44161706
90positive regulation of interferon-alpha production (GO:0032727)2.43999816
91detection of other organism (GO:0098543)2.43376964
92neutrophil activation involved in immune response (GO:0002283)2.42545467
93regulation of apoptotic process involved in morphogenesis (GO:1902337)2.42493440
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42146664
952-oxoglutarate metabolic process (GO:0006103)2.41953052
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.40664327
97regulation of T cell receptor signaling pathway (GO:0050856)2.40301587
98negative regulation of leukocyte mediated immunity (GO:0002704)2.39556786
99negative regulation of phagocytosis (GO:0050765)2.39466801
100response to muramyl dipeptide (GO:0032495)2.39072868
101positive regulation of natural killer cell differentiation (GO:0032825)2.38974997
102lysine metabolic process (GO:0006553)2.38916371
103lysine catabolic process (GO:0006554)2.38916371
104regulation of T cell tolerance induction (GO:0002664)2.36969562
105high-density lipoprotein particle remodeling (GO:0034375)2.36782586
106sulfur amino acid catabolic process (GO:0000098)2.36056801
107cysteine metabolic process (GO:0006534)2.35007879
108tolerance induction (GO:0002507)2.34963947
109membrane raft organization (GO:0031579)2.34029648
110regulation of T cell mediated cytotoxicity (GO:0001914)2.33854958
111negative regulation of erythrocyte differentiation (GO:0045647)2.33306723
112response to interferon-beta (GO:0035456)2.31794863
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.31463963
114negative regulation of cell killing (GO:0031342)2.31463963
115Golgi transport vesicle coating (GO:0048200)2.31299432
116COPI coating of Golgi vesicle (GO:0048205)2.31299432
117glyoxylate metabolic process (GO:0046487)2.31205297
118embryonic process involved in female pregnancy (GO:0060136)2.31110064
119amino-acid betaine metabolic process (GO:0006577)2.31081758
120complement activation, alternative pathway (GO:0006957)2.31037448
121response to laminar fluid shear stress (GO:0034616)2.30873691
122positive regulation of response to tumor cell (GO:0002836)2.30091142
123positive regulation of immune response to tumor cell (GO:0002839)2.30091142
124regulation of immune response to tumor cell (GO:0002837)2.30091142
125regulation of response to tumor cell (GO:0002834)2.30091142
126regulation of cholesterol esterification (GO:0010872)2.29805961
127negative regulation of viral release from host cell (GO:1902187)2.29454386
128regulation of interferon-alpha production (GO:0032647)2.28737166
129negative regulation of lymphocyte mediated immunity (GO:0002707)2.28512413
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.28372143
131response to host (GO:0075136)2.28372143
132response to host defenses (GO:0052200)2.28372143
133interferon-gamma-mediated signaling pathway (GO:0060333)2.27522694
134serine family amino acid biosynthetic process (GO:0009070)2.27279996
135positive regulation of natural killer cell mediated immunity (GO:0002717)2.26776981
136T cell costimulation (GO:0031295)2.26565763
137detection of external biotic stimulus (GO:0098581)2.26042451
138regulation of necrotic cell death (GO:0010939)2.25675144
139positive regulation of isotype switching (GO:0045830)2.25016150
140desmosome organization (GO:0002934)2.24914574
141cellular response to exogenous dsRNA (GO:0071360)2.24386648
142negative regulation of fibrinolysis (GO:0051918)2.23711847
143positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.23232801
144cellular response to interleukin-15 (GO:0071350)2.23201932
145cellular response to zinc ion (GO:0071294)2.22612949
146positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.22463343
147lipopolysaccharide-mediated signaling pathway (GO:0031663)2.22250649
148B cell receptor signaling pathway (GO:0050853)2.22131232
149peptidyl-glutamic acid carboxylation (GO:0017187)2.22038459
150protein carboxylation (GO:0018214)2.22038459
151regulation of cholesterol homeostasis (GO:2000188)2.21561742
152cellular response to interferon-beta (GO:0035458)2.21182260
153regulation of leukocyte mediated cytotoxicity (GO:0001910)2.20183478
154positive regulation of tumor necrosis factor production (GO:0032760)2.18129207
155regulation of antigen processing and presentation (GO:0002577)2.16833610
156mature B cell differentiation involved in immune response (GO:0002313)2.16746078
157positive regulation of histone deacetylation (GO:0031065)2.16543735
158response to host immune response (GO:0052572)2.16258750
159response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.16258750
160negative regulation of bone resorption (GO:0045779)2.16057412
161angiogenesis involved in wound healing (GO:0060055)2.15547710
162regulation of viral release from host cell (GO:1902186)2.13766165
163negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.13277990
164regulation of leukocyte degranulation (GO:0043300)2.11953262
165response to progesterone (GO:0032570)2.11186639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.26275133
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.02992739
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.97484524
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86530143
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.78290535
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.77896090
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76177560
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67202703
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60772812
10MYC_22102868_ChIP-Seq_BL_Human2.57921121
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54152639
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33029940
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.32093192
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25811435
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.20865151
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.14127206
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11824796
18* LXR_22158963_ChIP-Seq_LIVER_Mouse2.02192821
19VDR_21846776_ChIP-Seq_THP-1_Human2.02132636
20* RACK7_27058665_Chip-Seq_MCF-7_Human2.02091247
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00989641
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00904732
23GATA1_22025678_ChIP-Seq_K562_Human1.98225815
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97421941
25* MAF_26560356_Chip-Seq_TH1_Human1.96725629
26* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.95364875
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89779785
28MYB_26560356_Chip-Seq_TH2_Human1.87758406
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87446622
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82478762
31* MYB_26560356_Chip-Seq_TH1_Human1.82045294
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77893227
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77889693
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.73250142
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72846774
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71656639
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68465891
38UTX_26944678_Chip-Seq_JUKART_Human1.67301193
39SCL_19346495_ChIP-Seq_HPC-7_Human1.67024577
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.65277073
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.64856293
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63149647
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62193673
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60542773
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59473439
46* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59355283
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55586461
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55389190
49* SPI1_23547873_ChIP-Seq_NB4_Human1.55187441
50ZNF263_19887448_ChIP-Seq_K562_Human1.50939565
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49491528
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47468479
53RUNX_20019798_ChIP-Seq_JUKART_Human1.47087556
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46938915
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.46874128
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46857498
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46737490
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45974641
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.45305517
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.44529404
61TCF7_22412390_ChIP-Seq_EML_Mouse1.40500372
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39912462
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39630129
64* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37354490
65VDR_24763502_ChIP-Seq_THP-1_Human1.36505745
66* MAF_26560356_Chip-Seq_TH2_Human1.35946998
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33139744
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31944997
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.30089912
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28588770
71P68_20966046_ChIP-Seq_HELA_Human1.28176098
72BCOR_27268052_Chip-Seq_Bcells_Human1.27552968
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27213792
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24599843
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23532634
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22775733
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.22596478
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.22126167
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20370348
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.20229696
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19633928
82BCL6_27268052_Chip-Seq_Bcells_Human1.19310902
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18278678
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18218775
85* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17581749
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.16679173
87* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16596814
88* ELK3_25401928_ChIP-Seq_HUVEC_Human1.14805721
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14690463
90ATF3_27146783_Chip-Seq_COLON_Human1.14467436
91* SA1_27219007_Chip-Seq_ERYTHROID_Human1.14304769
92* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14187866
93* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13389242
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.13123667
95* GATA1_19941827_ChIP-Seq_MEL_Mouse1.13003249
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11878647
97SMC4_20622854_ChIP-Seq_HELA_Human1.11289773
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11166053
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10969436
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10879260
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.10310650
102E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09470118
103* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08717885
104GATA3_27048872_Chip-Seq_THYMUS_Human1.05808221
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03720180
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03291054
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02758850
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02239883
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01571810
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01183117
111CIITA_25753668_ChIP-Seq_RAJI_Human1.01132925
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98325505
113CLOCK_20551151_ChIP-Seq_293T_Human0.96358688
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96009665
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94972181
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94669185
117MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94433263
118SPI1_23127762_ChIP-Seq_K562_Human0.94052225
119VDR_23849224_ChIP-Seq_CD4+_Human0.93654538
120PU_27001747_Chip-Seq_BMDM_Mouse0.93277751
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92807622
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91633279
123FOXP3_21729870_ChIP-Seq_TREG_Human0.91346536
124* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91081518
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91036724
126KDM2B_26808549_Chip-Seq_DND41_Human0.89740927
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88038867
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87913218
129MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85811202
130LXR_22292898_ChIP-Seq_THP-1_Human0.85373305
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85317230
132NCOR1_26117541_ChIP-Seq_K562_Human0.83230861
133AR_21909140_ChIP-Seq_LNCAP_Human0.83144402
134MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82889413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.35040263
2MP0001835_abnormal_antigen_presentation2.97605065
3MP0002139_abnormal_hepatobiliary_system2.94725059
4MP0000685_abnormal_immune_system2.72486312
5MP0003763_abnormal_thymus_physiology2.61754283
6MP0005365_abnormal_bile_salt2.39508488
7MP0002166_altered_tumor_susceptibility2.39502087
8MP0005671_abnormal_response_to2.35224910
9MP0009840_abnormal_foam_cell2.34391297
10MP0005085_abnormal_gallbladder_physiolo2.31678516
11MP0001800_abnormal_humoral_immune2.27330996
12MP0003436_decreased_susceptibility_to2.20760242
13MP0001790_abnormal_immune_system2.07855575
14MP0005387_immune_system_phenotype2.07855575
15MP0009785_altered_susceptibility_to2.06668802
16MP0008875_abnormal_xenobiotic_pharmacok2.00069048
17MP0002396_abnormal_hematopoietic_system1.96224487
18MP0003300_gastrointestinal_ulcer1.94782904
19MP0005025_abnormal_response_to1.92601331
20MP0002452_abnormal_antigen_presenting1.89876388
21MP0003172_abnormal_lysosome_physiology1.88901818
22MP0002006_tumorigenesis1.87166463
23MP0002723_abnormal_immune_serum1.86876260
24MP0003191_abnormal_cellular_cholesterol1.86763920
25MP0005000_abnormal_immune_tolerance1.86530622
26MP0001873_stomach_inflammation1.79840012
27MP0010352_gastrointestinal_tract_polyps1.79238529
28MP0002420_abnormal_adaptive_immunity1.78881665
29MP0001819_abnormal_immune_cell1.77202463
30MP0002398_abnormal_bone_marrow1.74453147
31MP0003806_abnormal_nucleotide_metabolis1.74077260
32MP0010155_abnormal_intestine_physiology1.70772449
33MP0003724_increased_susceptibility_to1.70337101
34MP0005464_abnormal_platelet_physiology1.62457570
35MP0004947_skin_inflammation1.59867082
36MP0000716_abnormal_immune_system1.59690585
37MP0002419_abnormal_innate_immunity1.58182992
38MP0002405_respiratory_system_inflammati1.58142332
39MP0000689_abnormal_spleen_morphology1.57179492
40MP0003279_aneurysm1.55395066
41MP0010329_abnormal_lipoprotein_level1.54963911
42MP0009333_abnormal_splenocyte_physiolog1.54140476
43MP0001853_heart_inflammation1.54026097
44MP0002722_abnormal_immune_system1.53621556
45MP0002254_reproductive_system_inflammat1.53374425
46MP0003705_abnormal_hypodermis_morpholog1.52523486
47MP0000609_abnormal_liver_physiology1.51743394
48MP0003252_abnormal_bile_duct1.50804407
49MP0006082_CNS_inflammation1.49905666
50MP0002148_abnormal_hypersensitivity_rea1.49131432
51MP0008438_abnormal_cutaneous_collagen1.46609388
52MP0004185_abnormal_adipocyte_glucose1.45682317
53MP0001666_abnormal_nutrient_absorption1.42746307
54MP0001845_abnormal_inflammatory_respons1.42566786
55MP0002138_abnormal_hepatobiliary_system1.39978756
56MP0002429_abnormal_blood_cell1.38915364
57MP0008469_abnormal_protein_level1.38616900
58MP0002877_abnormal_melanocyte_morpholog1.34463166
59MP0003045_fibrosis1.34346759
60MP0001958_emphysema1.33905419
61MP0002998_abnormal_bone_remodeling1.30030559
62MP0003866_abnormal_defecation1.25782969
63MP0002796_impaired_skin_barrier1.25247384
64MP0000703_abnormal_thymus_morphology1.23148237
65MP0003091_abnormal_cell_migration1.22176211
66MP0002933_joint_inflammation1.21525872
67MP0001545_abnormal_hematopoietic_system1.19784520
68MP0005397_hematopoietic_system_phenotyp1.19784520
69MP0003303_peritoneal_inflammation1.18306646
70MP0005319_abnormal_enzyme/_coenzyme1.17010056
71MP0003183_abnormal_peptide_metabolism1.15023133
72MP0005332_abnormal_amino_acid1.11890794
73MP0003075_altered_response_to1.11444193
74MP0009643_abnormal_urine_homeostasis1.11292644
75MP0008260_abnormal_autophagy1.09589301
76MP0005083_abnormal_biliary_tract1.07664059
77MP0000490_abnormal_crypts_of1.06248262
78MP0003693_abnormal_embryo_hatching1.05516070
79MP0004808_abnormal_hematopoietic_stem1.03535701
80MP0000465_gastrointestinal_hemorrhage1.03527794
81MP0002132_abnormal_respiratory_system1.02829781
82MP0001533_abnormal_skeleton_physiology1.01045996
83MP0003186_abnormal_redox_activity1.00911569
84MP0005666_abnormal_adipose_tissue1.00847265
85MP0005375_adipose_tissue_phenotype0.99893079
86MP0000598_abnormal_liver_morphology0.99558287
87MP0002019_abnormal_tumor_incidence0.99035099
88MP0000858_altered_metastatic_potential0.98517637
89MP0005166_decreased_susceptibility_to0.98488629
90MP0005023_abnormal_wound_healing0.98470925
91MP0001849_ear_inflammation0.98281089
92MP0000678_abnormal_parathyroid_gland0.97901085
93MP0009763_increased_sensitivity_to0.97871505
94MP0010234_abnormal_vibrissa_follicle0.97798824
95MP0005310_abnormal_salivary_gland0.97409089
96MP0002060_abnormal_skin_morphology0.96492768
97MP0000681_abnormal_thyroid_gland0.95593648
98MP0005670_abnormal_white_adipose0.94684290
99MP0009764_decreased_sensitivity_to0.94396312
100MP0001348_abnormal_lacrimal_gland0.93908675
101MP0000013_abnormal_adipose_tissue0.92565099
102MP0001764_abnormal_homeostasis0.92299544
103MP0003656_abnormal_erythrocyte_physiolo0.92293349
104MP0008057_abnormal_DNA_replication0.92010287
105MP0002136_abnormal_kidney_physiology0.91272014
106MP0005076_abnormal_cell_differentiation0.90241155
107MP0005058_abnormal_lysosome_morphology0.89514045
108MP0004019_abnormal_vitamin_homeostasis0.89396674
109MP0005584_abnormal_enzyme/coenzyme_acti0.88672652
110MP0003828_pulmonary_edema0.88515168
111MP0005075_abnormal_melanosome_morpholog0.87818957
112MP0000003_abnormal_adipose_tissue0.87779525
113MP0004858_abnormal_nervous_system0.87034232
114MP0004510_myositis0.86446914
115MP0002118_abnormal_lipid_homeostasis0.85287572
116MP0005390_skeleton_phenotype0.84706156
117MP0005451_abnormal_body_composition0.83972900
118MP0003566_abnormal_cell_adhesion0.83907566
119MP0000249_abnormal_blood_vessel0.83905096
120MP0003795_abnormal_bone_structure0.83167683
121MP0003448_altered_tumor_morphology0.82226350
122MP0003453_abnormal_keratinocyte_physiol0.81291053
123MP0005164_abnormal_response_to0.80208655
124MP0006054_spinal_hemorrhage0.79836288
125MP0005165_increased_susceptibility_to0.79629555
126MP0004264_abnormal_extraembryonic_tissu0.79233971
127MP0010307_abnormal_tumor_latency0.76240124
128MP0001216_abnormal_epidermal_layer0.71191580
129MP0001851_eye_inflammation0.67930440
130MP0009278_abnormal_bone_marrow0.67565209
131MP0000477_abnormal_intestine_morphology0.67337148
132MP0010094_abnormal_chromosome_stability0.66868416
133MP0004957_abnormal_blastocyst_morpholog0.66400093
134MP0003077_abnormal_cell_cycle0.65785314

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)3.72530278
2Abnormality of liposaccharide metabolism (HP:0010968)3.72530278
3Abnormality of glycosphingolipid metabolism (HP:0004343)3.72530278
4Chronic otitis media (HP:0000389)3.39288335
5IgM deficiency (HP:0002850)3.30907206
6Recurrent viral infections (HP:0004429)3.24925196
7Recurrent fungal infections (HP:0002841)3.24587583
8Eczematoid dermatitis (HP:0000976)3.19923415
9Pustule (HP:0200039)3.19209777
10Recurrent bronchitis (HP:0002837)3.09108771
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07543066
12Abnormality of T cell number (HP:0011839)3.06803425
13T lymphocytopenia (HP:0005403)3.06655958
14Autoimmune thrombocytopenia (HP:0001973)3.05412153
15Thrombocytosis (HP:0001894)3.01931035
16Elevated erythrocyte sedimentation rate (HP:0003565)3.01077033
17Deep venous thrombosis (HP:0002625)2.97047692
18Abnormality of T cells (HP:0002843)2.95754060
19Hypobetalipoproteinemia (HP:0003563)2.94217349
20Abnormality of macrophages (HP:0004311)2.94084140
21Xanthomatosis (HP:0000991)2.94005286
22Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93646939
23Abnormality of polysaccharide metabolism (HP:0011012)2.93646939
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93646939
25Nasal polyposis (HP:0100582)2.90534790
26Dysostosis multiplex (HP:0000943)2.88204097
27Chronic mucocutaneous candidiasis (HP:0002728)2.87293372
28Recurrent cutaneous fungal infections (HP:0011370)2.87293372
29Intrahepatic cholestasis (HP:0001406)2.86503703
30Combined immunodeficiency (HP:0005387)2.86019237
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83205595
32Abnormality of T cell physiology (HP:0011840)2.74384339
33Severe combined immunodeficiency (HP:0004430)2.71659107
34Vertebral compression fractures (HP:0002953)2.69290645
35Recurrent bacterial skin infections (HP:0005406)2.68971559
36Myocardial infarction (HP:0001658)2.68889367
37Panhypogammaglobulinemia (HP:0003139)2.68740044
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.67861048
39Myositis (HP:0100614)2.67281349
40Gingival bleeding (HP:0000225)2.67240582
41Mucopolysacchariduria (HP:0008155)2.66553144
42Urinary glycosaminoglycan excretion (HP:0003541)2.66553144
43Abnormality of the nasal mucosa (HP:0000433)2.64306993
44Recurrent abscess formation (HP:0002722)2.61705641
45Recurrent skin infections (HP:0001581)2.56306667
46Orchitis (HP:0100796)2.50163323
47Abnormality of the distal phalanges of the toes (HP:0010182)2.48611335
48Prolonged partial thromboplastin time (HP:0003645)2.48087730
49Spontaneous hematomas (HP:0007420)2.47332130
50Cervical subluxation (HP:0003308)2.45802991
51Inflammation of the large intestine (HP:0002037)2.44438072
52Increased IgM level (HP:0003496)2.42882138
53Gastrointestinal inflammation (HP:0004386)2.40101092
54Hyperammonemia (HP:0001987)2.38792125
55Recurrent gram-negative bacterial infections (HP:0005420)2.38580932
56Distal lower limb muscle weakness (HP:0009053)2.34009902
57Protrusio acetabuli (HP:0003179)2.33953439
58Chronic diarrhea (HP:0002028)2.32602651
59Abnormality of glutamine family amino acid metabolism (HP:0010902)2.31958306
60IgG deficiency (HP:0004315)2.31923798
61Agammaglobulinemia (HP:0004432)2.29933447
62Fatigue (HP:0012378)2.27853466
63Gingivitis (HP:0000230)2.26866277
64Abnormality of the common coagulation pathway (HP:0010990)2.26260109
65Joint hemorrhage (HP:0005261)2.26174296
66Abnormality of fatty-acid metabolism (HP:0004359)2.26105140
67Colitis (HP:0002583)2.24190700
68Epistaxis (HP:0000421)2.23057272
69Complement deficiency (HP:0004431)2.22738087
70Hyperlipoproteinemia (HP:0010980)2.21537877
71Interstitial pulmonary disease (HP:0006530)2.20954175
72Hypolipoproteinemia (HP:0010981)2.20690700
73Lymphopenia (HP:0001888)2.16993545
74Periodontitis (HP:0000704)2.16654618
75Emphysema (HP:0002097)2.16619526
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.16568293
77Abnormal platelet volume (HP:0011876)2.16368431
78Malnutrition (HP:0004395)2.16208538
79Pulmonary infiltrates (HP:0002113)2.13646613
80Glucose intolerance (HP:0000833)2.13549229
81Obstructive sleep apnea (HP:0002870)2.11255812
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.10983238
83Esophageal varix (HP:0002040)2.09881748
84Broad face (HP:0000283)2.09567297
85Premature rupture of membranes (HP:0001788)2.09077765
86Autoimmune hemolytic anemia (HP:0001890)2.09017172
87Spondylolisthesis (HP:0003302)2.08673343
88Abnormality of pyrimidine metabolism (HP:0004353)2.07671471
89Petechiae (HP:0000967)2.07652363
90Progressive neurologic deterioration (HP:0002344)2.07594353
91Increased cerebral lipofuscin (HP:0011813)2.06954525
92IgA deficiency (HP:0002720)2.06822422
93Joint swelling (HP:0001386)2.06241069
94Vasculitis (HP:0002633)2.05884933
95Hypoplasia of the thymus (HP:0000778)2.05204076
96Thyroiditis (HP:0100646)2.04644147
97Meningitis (HP:0001287)2.04182693
98Granulocytopenia (HP:0001913)2.03509871
99Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03011363
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02582154
101Vacuolated lymphocytes (HP:0001922)2.02479291
102Loss of speech (HP:0002371)2.00904615
103Verrucae (HP:0200043)1.99934651
104Papilloma (HP:0012740)1.99934651
105Cellulitis (HP:0100658)1.99834244
106Eosinophilia (HP:0001880)1.99679935
107Fat malabsorption (HP:0002630)1.99327340
108Abnormality of eosinophils (HP:0001879)1.98210075
109Arterial thrombosis (HP:0004420)1.98103057
110Obstructive lung disease (HP:0006536)1.97874472
111Chronic obstructive pulmonary disease (HP:0006510)1.97874472
112Flat acetabular roof (HP:0003180)1.97488619
113Optic neuritis (HP:0100653)1.96895878
114Retrobulbar optic neuritis (HP:0100654)1.96895878
115Encephalitis (HP:0002383)1.95840857
116Purpura (HP:0000979)1.95256859
117Mediastinal lymphadenopathy (HP:0100721)1.94513194
118Increased IgE level (HP:0003212)1.94383989
119Growth hormone excess (HP:0000845)1.94134720
120Aortic aneurysm (HP:0004942)1.92592873
121Leukocytosis (HP:0001974)1.92435790
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92255989
123Stridor (HP:0010307)1.92058243
124B lymphocytopenia (HP:0010976)1.91943396
125Abnormality of B cell number (HP:0010975)1.91943396
126Hypergammaglobulinemia (HP:0010702)1.91837210
127Osteolytic defects of the hand bones (HP:0009699)1.90928304
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.90928304
129Mitral stenosis (HP:0001718)1.90674164
130Epidermoid cyst (HP:0200040)1.89829808
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.89427570
132Increased mean platelet volume (HP:0011877)1.88277859
133Polycythemia (HP:0001901)1.88112053
134Polygenic inheritance (HP:0010982)1.88060495
135Hemorrhage of the eye (HP:0011885)1.87806741
136Abnormality of the intrinsic pathway (HP:0010989)1.87624767
137Nonimmune hydrops fetalis (HP:0001790)1.87525325
138Cheilitis (HP:0100825)1.87448334
139Increased connective tissue (HP:0009025)1.87221668
140Abnormality of the fingertips (HP:0001211)1.86302940
141Skin rash (HP:0000988)1.86291317
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85927847
143Short nail (HP:0001799)1.85509999
144Abnormality of complement system (HP:0005339)1.85283610
145Hyperglycinuria (HP:0003108)1.85246282
146Impaired platelet aggregation (HP:0003540)1.84979308
147Abnormal platelet function (HP:0011869)1.84979308
148Asymmetric septal hypertrophy (HP:0001670)1.84892269
149Systemic lupus erythematosus (HP:0002725)1.84490969
150Gastrointestinal stroma tumor (HP:0100723)1.84220957
151Thrombophlebitis (HP:0004418)1.84123234
152Hypertriglyceridemia (HP:0002155)1.83042906
153Dilatation of the ascending aorta (HP:0005111)1.76726743
154Increased serum ferritin (HP:0003281)1.75620553
155Generalized amyotrophy (HP:0003700)1.74942529
156Urticaria (HP:0001025)1.74406070
157Joint stiffness (HP:0001387)1.74228668
158Advanced eruption of teeth (HP:0006288)1.74099658
159Hemoptysis (HP:0002105)1.74041665
160Prolonged bleeding time (HP:0003010)1.73337941
161Gastrointestinal infarctions (HP:0005244)1.71276361
162J-shaped sella turcica (HP:0002680)1.70641601
163Cerebral aneurysm (HP:0004944)1.70461310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.63179374
2FGFR43.30653299
3JAK32.96253145
4SMG12.91607179
5TYK22.87014138
6EEF2K2.33864962
7ERN12.33607465
8TRIB32.21364246
9TXK2.21092788
10ZAP702.20558819
11TBK12.09857674
12IKBKE2.08166533
13GRK62.01776312
14KIT2.01048059
15STK101.99545699
16MAP3K141.97000527
17MAP3K101.95843666
18PRPF4B1.95269603
19PKN21.94943537
20BLK1.92192898
21KDR1.81518720
22FLT31.78718262
23FGFR31.68726107
24JAK11.67639438
25BTK1.65805979
26NME21.65368741
27TESK11.64285273
28BCKDK1.58731873
29LRRK21.56332506
30NLK1.53750557
31ITK1.52942813
32CSF1R1.51558227
33IRAK31.49784707
34TNK21.48117714
35RIPK41.47816578
36MAP2K31.45621564
37SIK11.40158651
38TGFBR21.32375914
39MST41.31319990
40TEC1.30343271
41PRKD21.29507631
42CDK121.28466839
43SYK1.26183792
44HIPK21.22953964
45MAP3K31.20055863
46IKBKB1.19905129
47EPHB11.19425491
48MAPK111.18939974
49LCK1.15329426
50CDC42BPA1.14087167
51CDK41.13461717
52ICK1.09300437
53CSK1.05567842
54RPS6KA41.05161476
55STK381.04650427
56PIM11.00207020
57NEK90.98995664
58TAOK30.96063252
59FES0.95956111
60IRAK40.95556193
61RPS6KB20.95406051
62PDPK10.94957652
63TGFBR10.94508557
64MAP3K10.93778861
65JAK20.92845500
66TTN0.91983568
67PTK60.88517436
68HCK0.88510464
69MYLK0.87754144
70SCYL20.84177534
71PIM20.80169987
72TAOK20.79499326
73PRKCI0.79054302
74CHUK0.78830704
75MARK20.77770079
76MST1R0.76361104
77MAP3K110.75608587
78LYN0.73178224
79EPHA30.72677572
80RPS6KA20.69637929
81TESK20.69619576
82PTK20.69189482
83CDK60.66560766
84MAP3K70.65815418
85LMTK20.65338905
86MAPK150.64138021
87ACVR1B0.63564567
88RIPK10.61448671
89STK40.61029607
90MAP3K80.59205228
91RPS6KC10.58613762
92RPS6KL10.58613762
93EPHA20.58005308
94FRK0.56958300
95MAP3K20.56910525
96FGR0.56757122
97MARK30.56270440
98MTOR0.56117471
99MAPKAPK30.55629682
100FER0.54398057
101NEK20.54028305
102SIK30.53641205
103ABL20.49354091
104MAP3K130.48876862
105PAK40.47183653
106MAP2K60.45793671
107TRPM70.45778549
108WEE10.44690671
109RPS6KA60.43332712
110TSSK60.41336852
111MAPK40.40834444
112CLK10.37657250
113PRKCQ0.37502259
114PRKG20.37480493
115TAOK10.35932306
116MAP2K20.35806830
117EIF2AK10.35207010
118AURKB0.32788426
119PDK10.32166041
120PRKAA20.32146625
121ABL10.31978763
122MAPKAPK20.31738362
123MAPK120.30013986
124SIK20.29949783
125BRSK20.29580497
126PRKCD0.29338173
127MELK0.28973117
128NUAK10.28503098
129CDK90.27548417
130PRKCH0.27246868
131PASK0.27180820

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.93569931
2Autoimmune thyroid disease_Homo sapiens_hsa053202.58574309
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50051161
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49270461
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.34218153
6Caffeine metabolism_Homo sapiens_hsa002322.32214169
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.31111796
8Staphylococcus aureus infection_Homo sapiens_hsa051501.93237486
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.91049461
10Antigen processing and presentation_Homo sapiens_hsa046121.81360535
11Type I diabetes mellitus_Homo sapiens_hsa049401.80721442
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74723250
13Lysosome_Homo sapiens_hsa041421.73095240
14Fatty acid degradation_Homo sapiens_hsa000711.70362902
15Arginine biosynthesis_Homo sapiens_hsa002201.67513694
16Tryptophan metabolism_Homo sapiens_hsa003801.62014439
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.61833377
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.61072520
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.56580828
20DNA replication_Homo sapiens_hsa030301.54798710
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.53057560
22Complement and coagulation cascades_Homo sapiens_hsa046101.52597369
23Measles_Homo sapiens_hsa051621.51890418
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51142776
25Asthma_Homo sapiens_hsa053101.44602511
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44524944
27Selenocompound metabolism_Homo sapiens_hsa004501.40646473
28Leishmaniasis_Homo sapiens_hsa051401.37787890
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35693612
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34072647
31Folate biosynthesis_Homo sapiens_hsa007901.31985733
32One carbon pool by folate_Homo sapiens_hsa006701.30035717
33Pentose phosphate pathway_Homo sapiens_hsa000301.23541631
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20317197
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19082188
36B cell receptor signaling pathway_Homo sapiens_hsa046621.18454966
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16705256
38PPAR signaling pathway_Homo sapiens_hsa033201.16689672
39Nitrogen metabolism_Homo sapiens_hsa009101.16385806
40Peroxisome_Homo sapiens_hsa041461.14681802
41Sulfur relay system_Homo sapiens_hsa041221.14174606
42Graft-versus-host disease_Homo sapiens_hsa053321.12343279
43Herpes simplex infection_Homo sapiens_hsa051681.12169909
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11487107
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09005978
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08108123
47Starch and sucrose metabolism_Homo sapiens_hsa005001.07189884
48T cell receptor signaling pathway_Homo sapiens_hsa046601.07140743
49Osteoclast differentiation_Homo sapiens_hsa043801.07046075
50Chemical carcinogenesis_Homo sapiens_hsa052041.05099732
51beta-Alanine metabolism_Homo sapiens_hsa004101.04822677
52Ribosome_Homo sapiens_hsa030101.04799652
53Mismatch repair_Homo sapiens_hsa034301.03782253
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03142780
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03114501
56Biosynthesis of amino acids_Homo sapiens_hsa012301.00459622
57Legionellosis_Homo sapiens_hsa051341.00375254
58Carbon metabolism_Homo sapiens_hsa012000.98413386
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98172812
60Propanoate metabolism_Homo sapiens_hsa006400.98019804
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.96525524
62Histidine metabolism_Homo sapiens_hsa003400.94937741
63Hematopoietic cell lineage_Homo sapiens_hsa046400.93962268
64Fat digestion and absorption_Homo sapiens_hsa049750.93539521
65Base excision repair_Homo sapiens_hsa034100.92293957
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.91341533
67Chronic myeloid leukemia_Homo sapiens_hsa052200.91287404
68ABC transporters_Homo sapiens_hsa020100.90939547
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90400254
70mTOR signaling pathway_Homo sapiens_hsa041500.89463611
71Allograft rejection_Homo sapiens_hsa053300.88621209
72Rheumatoid arthritis_Homo sapiens_hsa053230.85934215
73Fatty acid metabolism_Homo sapiens_hsa012120.84848952
74Pancreatic cancer_Homo sapiens_hsa052120.84311219
75Notch signaling pathway_Homo sapiens_hsa043300.83584120
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81202517
77Influenza A_Homo sapiens_hsa051640.79901001
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79299629
79Vitamin digestion and absorption_Homo sapiens_hsa049770.79237533
80Lysine degradation_Homo sapiens_hsa003100.79053764
81Toxoplasmosis_Homo sapiens_hsa051450.77883878
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.77667825
83Retinol metabolism_Homo sapiens_hsa008300.76607985
84Phagosome_Homo sapiens_hsa041450.76164853
85Endocytosis_Homo sapiens_hsa041440.74356892
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74028386
87Non-small cell lung cancer_Homo sapiens_hsa052230.73044815
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72770617
89Phenylalanine metabolism_Homo sapiens_hsa003600.71366201
90Bladder cancer_Homo sapiens_hsa052190.71345453
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71141709
92Viral myocarditis_Homo sapiens_hsa054160.70832952
93Platelet activation_Homo sapiens_hsa046110.70568619
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.70564729
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70333597
96Acute myeloid leukemia_Homo sapiens_hsa052210.69697703
97Apoptosis_Homo sapiens_hsa042100.69110183
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68252016
99HTLV-I infection_Homo sapiens_hsa051660.67939405
100Galactose metabolism_Homo sapiens_hsa000520.67670259
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.65839678
102Fructose and mannose metabolism_Homo sapiens_hsa000510.64621488
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62184735
104Malaria_Homo sapiens_hsa051440.62149490
105Focal adhesion_Homo sapiens_hsa045100.62002966
106Pyruvate metabolism_Homo sapiens_hsa006200.61345710
107Hepatitis B_Homo sapiens_hsa051610.61224280
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61001206
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60971202
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59282889
111Viral carcinogenesis_Homo sapiens_hsa052030.58997550
112Chemokine signaling pathway_Homo sapiens_hsa040620.58799477
113Amoebiasis_Homo sapiens_hsa051460.58014113
114Renal cell carcinoma_Homo sapiens_hsa052110.57675571
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56674351
116Pertussis_Homo sapiens_hsa051330.56116643
117Salmonella infection_Homo sapiens_hsa051320.55791031
118Other glycan degradation_Homo sapiens_hsa005110.55346594
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55334495
120Hepatitis C_Homo sapiens_hsa051600.55288104
121VEGF signaling pathway_Homo sapiens_hsa043700.55258650
122Pyrimidine metabolism_Homo sapiens_hsa002400.53952561
123Tyrosine metabolism_Homo sapiens_hsa003500.53169435
124Sphingolipid metabolism_Homo sapiens_hsa006000.53082141
125Small cell lung cancer_Homo sapiens_hsa052220.53056481
126Proteasome_Homo sapiens_hsa030500.50940731
127Epstein-Barr virus infection_Homo sapiens_hsa051690.50643129
128TNF signaling pathway_Homo sapiens_hsa046680.50050718
129Glutathione metabolism_Homo sapiens_hsa004800.49992843
130Shigellosis_Homo sapiens_hsa051310.49873394
131Bile secretion_Homo sapiens_hsa049760.49165869
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48694617
133Vibrio cholerae infection_Homo sapiens_hsa051100.47988830
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47452107
135African trypanosomiasis_Homo sapiens_hsa051430.46984012
136Tuberculosis_Homo sapiens_hsa051520.46774351
137Insulin resistance_Homo sapiens_hsa049310.45956306
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45498900
139Arginine and proline metabolism_Homo sapiens_hsa003300.44865639
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44538761
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.43933501
142Arachidonic acid metabolism_Homo sapiens_hsa005900.43687776
143Renin-angiotensin system_Homo sapiens_hsa046140.43516194
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.43289186
145Prostate cancer_Homo sapiens_hsa052150.42464531
146N-Glycan biosynthesis_Homo sapiens_hsa005100.42425485

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